WDPCP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.24396974
2epithelial cilium movement (GO:0003351)8.79414948
3cilium movement (GO:0003341)8.58035955
4axonemal dynein complex assembly (GO:0070286)8.32585193
5motile cilium assembly (GO:0044458)7.30637682
6sperm motility (GO:0030317)6.72651861
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.64483752
8fusion of sperm to egg plasma membrane (GO:0007342)6.38277281
9protein localization to cilium (GO:0061512)6.26989740
10ventricular system development (GO:0021591)6.21683450
11regulation of cilium movement (GO:0003352)5.74274625
12acrosome reaction (GO:0007340)5.64510946
13acrosome assembly (GO:0001675)5.54048479
14intraciliary transport (GO:0042073)5.44100759
15axoneme assembly (GO:0035082)5.33496986
16cell wall macromolecule catabolic process (GO:0016998)5.13646047
17cell wall macromolecule metabolic process (GO:0044036)5.13646047
18spermatid development (GO:0007286)5.12618739
19multicellular organism reproduction (GO:0032504)5.07298728
20plasma membrane fusion (GO:0045026)5.01049797
21sperm-egg recognition (GO:0035036)4.93850384
22piRNA metabolic process (GO:0034587)4.84937259
23presynaptic membrane assembly (GO:0097105)4.81650027
24tryptophan catabolic process (GO:0006569)4.73481894
25indole-containing compound catabolic process (GO:0042436)4.73481894
26indolalkylamine catabolic process (GO:0046218)4.73481894
27kynurenine metabolic process (GO:0070189)4.68695714
28behavioral response to nicotine (GO:0035095)4.62338124
29* cilium morphogenesis (GO:0060271)4.45932054
30binding of sperm to zona pellucida (GO:0007339)4.37216478
31left/right pattern formation (GO:0060972)4.32473710
32presynaptic membrane organization (GO:0097090)4.32238207
33* cilium organization (GO:0044782)4.30802342
34cell-cell recognition (GO:0009988)4.29667372
35indolalkylamine metabolic process (GO:0006586)4.26612562
36* cilium assembly (GO:0042384)4.21748276
37positive regulation of developmental pigmentation (GO:0048087)4.20481575
38regulation of hippo signaling (GO:0035330)4.17018047
39regulation of pigment cell differentiation (GO:0050932)4.16911582
40regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.16168693
41spermatid nucleus differentiation (GO:0007289)4.12225418
42male meiosis (GO:0007140)4.08291103
43reproduction (GO:0000003)4.04756157
44negative regulation of sodium ion transport (GO:0010766)4.01904531
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.98072069
46negative regulation of translation, ncRNA-mediated (GO:0040033)3.98072069
47regulation of translation, ncRNA-mediated (GO:0045974)3.98072069
48snRNA transcription (GO:0009301)3.95380452
49tryptophan metabolic process (GO:0006568)3.94475052
50single fertilization (GO:0007338)3.91077395
51interkinetic nuclear migration (GO:0022027)3.87059816
52GTP biosynthetic process (GO:0006183)3.78088494
53regulation of posttranscriptional gene silencing (GO:0060147)3.77339997
54regulation of gene silencing by miRNA (GO:0060964)3.77339997
55regulation of gene silencing by RNA (GO:0060966)3.77339997
56protein K48-linked deubiquitination (GO:0071108)3.76278657
57postsynaptic membrane organization (GO:0001941)3.70547362
58fucose catabolic process (GO:0019317)3.66661302
59L-fucose metabolic process (GO:0042354)3.66661302
60L-fucose catabolic process (GO:0042355)3.66661302
61calcium ion-dependent exocytosis (GO:0017156)3.66070430
62centriole assembly (GO:0098534)3.58564374
63monoubiquitinated protein deubiquitination (GO:0035520)3.58115710
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.54101251
65* cellular component assembly involved in morphogenesis (GO:0010927)3.53545338
66regulation of microtubule-based movement (GO:0060632)3.53283325
67neural tube formation (GO:0001841)3.53020361
68reflex (GO:0060004)3.52660840
69endosome to pigment granule transport (GO:0043485)3.51986898
70endosome to melanosome transport (GO:0035646)3.51986898
71sperm capacitation (GO:0048240)3.51930406
72establishment of protein localization to Golgi (GO:0072600)3.50576068
73nonmotile primary cilium assembly (GO:0035058)3.50558220
74gamma-aminobutyric acid transport (GO:0015812)3.50553106
75DNA methylation involved in gamete generation (GO:0043046)3.44875275
76oxidative demethylation (GO:0070989)3.44843108
77cellular biogenic amine catabolic process (GO:0042402)3.40695521
78amine catabolic process (GO:0009310)3.40695521
79sulfation (GO:0051923)3.39650028
80microtubule-based movement (GO:0007018)3.37179712
81nucleoside diphosphate phosphorylation (GO:0006165)3.35526945
82replicative senescence (GO:0090399)3.33368589
83detection of light stimulus involved in sensory perception (GO:0050962)3.32095785
84detection of light stimulus involved in visual perception (GO:0050908)3.32095785
85indole-containing compound metabolic process (GO:0042430)3.31948154
86left/right axis specification (GO:0070986)3.30141454
87signal peptide processing (GO:0006465)3.27764776
88male meiosis I (GO:0007141)3.24751294
89negative regulation of inclusion body assembly (GO:0090084)3.24099210
90CTP biosynthetic process (GO:0006241)3.23658416
91CTP metabolic process (GO:0046036)3.23658416
92daunorubicin metabolic process (GO:0044597)3.20930725
93polyketide metabolic process (GO:0030638)3.20930725
94doxorubicin metabolic process (GO:0044598)3.20930725
95negative regulation of systemic arterial blood pressure (GO:0003085)3.17847176
96lactate metabolic process (GO:0006089)3.15445318
97flavonoid metabolic process (GO:0009812)3.08605518
98fertilization (GO:0009566)3.08461759
99phospholipid translocation (GO:0045332)3.06716310
100lipid translocation (GO:0034204)3.06716310
101leukocyte migration involved in inflammatory response (GO:0002523)3.05601525
102negative regulation of protein localization to cell surface (GO:2000009)3.04312725
103neuronal action potential (GO:0019228)3.03577730
104serotonin metabolic process (GO:0042428)3.03152065
105primary amino compound metabolic process (GO:1901160)3.02776753
106synaptonemal complex organization (GO:0070193)2.99814719
107cellular ketone body metabolic process (GO:0046950)2.97927022
108* smoothened signaling pathway (GO:0007224)2.97536622
109spermatogenesis (GO:0007283)2.96374045
110male gamete generation (GO:0048232)2.95654942
111protein K63-linked deubiquitination (GO:0070536)2.95368804
112UTP biosynthetic process (GO:0006228)2.92777970
113peristalsis (GO:0030432)2.92168922
114neuron cell-cell adhesion (GO:0007158)2.92097925
115negative regulation of mast cell activation (GO:0033004)2.89701302
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88192852
117protein K11-linked deubiquitination (GO:0035871)2.87734107
118NAD biosynthetic process (GO:0009435)2.86135765
119photoreceptor cell maintenance (GO:0045494)2.85245144
120photoreceptor cell differentiation (GO:0046530)2.84632795
121eye photoreceptor cell differentiation (GO:0001754)2.84632795
122organic cation transport (GO:0015695)2.84386545
123intra-Golgi vesicle-mediated transport (GO:0006891)2.82548199
124startle response (GO:0001964)2.81863127
125thyroid hormone metabolic process (GO:0042403)2.77996026
126germ cell development (GO:0007281)2.76952561
127protein polyglutamylation (GO:0018095)2.76622010
128meiosis I (GO:0007127)2.76344295
129cellular response to ATP (GO:0071318)2.76296489
130negative regulation of immunoglobulin mediated immune response (GO:0002890)2.76217718
131negative regulation of B cell mediated immunity (GO:0002713)2.76217718
132microtubule bundle formation (GO:0001578)2.74462524
133pericardium development (GO:0060039)2.74311182
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.72571840
135gamete generation (GO:0007276)2.71895934
136musculoskeletal movement (GO:0050881)2.69958104
137multicellular organismal movement (GO:0050879)2.69958104
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68455781
139microtubule depolymerization (GO:0007019)2.67663466
140protein targeting to vacuole (GO:0006623)2.67569630
141protein targeting to lysosome (GO:0006622)2.67569630
142establishment of protein localization to vacuole (GO:0072666)2.67569630
143righting reflex (GO:0060013)2.67394432
144cellular response to ethanol (GO:0071361)2.65875856
145membrane depolarization during action potential (GO:0086010)2.65656455
146negative regulation of transcription by competitive promoter binding (GO:0010944)2.65150885
147pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.64726037
148ketone body metabolic process (GO:1902224)2.63867382
149urinary tract smooth muscle contraction (GO:0014848)2.63729194
150regulation of sarcomere organization (GO:0060297)2.63216066
151behavioral response to ethanol (GO:0048149)2.62673624
152spinal cord motor neuron differentiation (GO:0021522)2.62354502
153kidney morphogenesis (GO:0060993)2.61979179
154nucleotide transmembrane transport (GO:1901679)2.61305411
155positive regulation of dendritic spine morphogenesis (GO:0061003)2.61172322
156positive regulation of CREB transcription factor activity (GO:0032793)2.61161221
157benzene-containing compound metabolic process (GO:0042537)2.60145743
158regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59385124
159positive regulation of protein homodimerization activity (GO:0090073)2.59379349
160regulation of respiratory system process (GO:0044065)2.58577439
161cellular response to sterol (GO:0036315)2.58163136
162retinal rod cell development (GO:0046548)2.57925240
163cellular process involved in reproduction in multicellular organism (GO:0022412)2.57865433
164protein localization to synapse (GO:0035418)2.57736122
165sequestering of metal ion (GO:0051238)2.56552389
166neuronal action potential propagation (GO:0019227)2.56542469
167retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55876552
168UTP metabolic process (GO:0046051)2.55464112
169regulation of mesoderm development (GO:2000380)2.55295684
170pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54990725
171synaptonemal complex assembly (GO:0007130)2.54882116
172cAMP catabolic process (GO:0006198)2.54139344
173endocardial cushion development (GO:0003197)2.52304182
174macroautophagy (GO:0016236)2.51737154
175centriole replication (GO:0007099)2.50828053
176negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.49578368
177detection of mechanical stimulus involved in sensory perception (GO:0050974)2.48167602
178regulation of type B pancreatic cell apoptotic process (GO:2000674)2.48094893
179reciprocal DNA recombination (GO:0035825)2.46878641
180reciprocal meiotic recombination (GO:0007131)2.46878641
181synaptic vesicle docking involved in exocytosis (GO:0016081)2.46773469
182regulation of action potential (GO:0098900)2.45138246
183proline transport (GO:0015824)2.42865166
184positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.42458165
185limb development (GO:0060173)2.42128998
186appendage development (GO:0048736)2.42128998
187negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38786733
188drug catabolic process (GO:0042737)2.38737744
189DNA demethylation (GO:0080111)2.37127190
190regulation of neurotransmitter uptake (GO:0051580)2.36869976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55632006
2GBX2_23144817_ChIP-Seq_PC3_Human4.04228525
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16933884
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65716689
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58819103
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49906075
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42272241
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32700719
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21608343
10TAF15_26573619_Chip-Seq_HEK293_Human2.21149815
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19997047
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10384843
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.06255515
14EWS_26573619_Chip-Seq_HEK293_Human1.95776636
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92800524
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.92717382
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90935307
18SMAD4_21799915_ChIP-Seq_A2780_Human1.85637240
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84669365
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81553936
21TP53_16413492_ChIP-PET_HCT116_Human1.74355062
22TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73366265
23P300_19829295_ChIP-Seq_ESCs_Human1.72592435
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70003856
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.68918450
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67519745
27DROSHA_22980978_ChIP-Seq_HELA_Human1.64560098
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64451188
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63430791
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59740515
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59108536
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.58558137
33REST_21632747_ChIP-Seq_MESCs_Mouse1.57287650
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57039992
35TCF4_23295773_ChIP-Seq_U87_Human1.55880020
36BCAT_22108803_ChIP-Seq_LS180_Human1.52906739
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52707677
38AR_21572438_ChIP-Seq_LNCaP_Human1.52331131
39STAT3_23295773_ChIP-Seq_U87_Human1.51719371
40FUS_26573619_Chip-Seq_HEK293_Human1.51305433
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51063486
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49974780
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.48759932
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.48581921
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48299831
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47816061
47P53_22387025_ChIP-Seq_ESCs_Mouse1.47774990
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.46329190
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.45908075
50ER_23166858_ChIP-Seq_MCF-7_Human1.45504574
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43495189
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.42955906
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.40796449
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40244814
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39473045
56AHR_22903824_ChIP-Seq_MCF-7_Human1.39020410
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37325714
58P300_18555785_Chip-Seq_ESCs_Mouse1.37026133
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36122177
60TCF4_22108803_ChIP-Seq_LS180_Human1.35809482
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35234700
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.35051138
63CBP_20019798_ChIP-Seq_JUKART_Human1.34461405
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34461405
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.34295385
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.33486547
67RNF2_27304074_Chip-Seq_NSC_Mouse1.32495837
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32317476
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32003859
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31925201
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30622602
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30540482
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29527316
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29238458
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28934554
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28278049
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27395796
78KDM2B_26808549_Chip-Seq_REH_Human1.26673106
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.26061518
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.26044015
81VDR_22108803_ChIP-Seq_LS180_Human1.25702567
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25464207
83AR_25329375_ChIP-Seq_VCAP_Human1.25031003
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.24944923
85RUNX2_22187159_ChIP-Seq_PCA_Human1.23420768
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23186745
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23131434
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22181170
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.21071548
90ZNF274_21170338_ChIP-Seq_K562_Hela1.21031562
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20732251
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20576387
93IGF1R_20145208_ChIP-Seq_DFB_Human1.20464397
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.20328914
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19596224
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.18189781
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18167302
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.17599428
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.17252876
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16627075
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16627075
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.16563634
103ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15611816
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15547201
105RXR_22108803_ChIP-Seq_LS180_Human1.15282314
106TP53_18474530_ChIP-ChIP_U2OS_Human1.14171292
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.14088816
108PU1_27457419_Chip-Seq_LIVER_Mouse1.13331965
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12825741
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12036862
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11799457
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11552958
113KLF4_18555785_Chip-Seq_ESCs_Mouse1.11149936
114MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11137309
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.11096240
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10966152
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10376239
118SOX2_19829295_ChIP-Seq_ESCs_Human1.09411221
119NANOG_19829295_ChIP-Seq_ESCs_Human1.09411221
120IRF1_19129219_ChIP-ChIP_H3396_Human1.07854959
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07564701
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06951922
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06556136
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06350565
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04444053
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01624681
127SMAD3_21741376_ChIP-Seq_ESCs_Human1.00049167
128CDX2_22108803_ChIP-Seq_LS180_Human1.00000339
129TP53_22573176_ChIP-Seq_HFKS_Human0.99736697
130SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98136724
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.97065078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.87755945
2MP0000569_abnormal_digit_pigmentation4.25160194
3MP0005171_absent_coat_pigmentation4.16479354
4MP0003646_muscle_fatigue3.59503889
5MP0003195_calcinosis3.53672862
6MP0003880_abnormal_central_pattern3.21570491
7MP0008057_abnormal_DNA_replication3.06493012
8MP0002009_preneoplasia2.58636175
9MP0003698_abnormal_male_reproductive2.42476470
10MP0009780_abnormal_chondrocyte_physiolo2.39765266
11MP0005646_abnormal_pituitary_gland2.34418933
12MP0005379_endocrine/exocrine_gland_phen2.33023970
13MP0006072_abnormal_retinal_apoptosis2.27178112
14MP0000427_abnormal_hair_cycle2.27124560
15MP0003283_abnormal_digestive_organ2.20265892
16MP0003724_increased_susceptibility_to2.16083768
17MP0004142_abnormal_muscle_tone2.15328023
18MP0001984_abnormal_olfaction2.15093779
19MP0001501_abnormal_sleep_pattern2.14587149
20MP0001986_abnormal_taste_sensitivity2.09454012
21MP0001929_abnormal_gametogenesis2.09384384
22MP0002735_abnormal_chemical_nociception1.99408616
23MP0010386_abnormal_urinary_bladder1.94994589
24MP0008961_abnormal_basal_metabolism1.88537255
25MP0000383_abnormal_hair_follicle1.88250629
26MP0008877_abnormal_DNA_methylation1.86894193
27MP0005551_abnormal_eye_electrophysiolog1.86669155
28MP0000372_irregular_coat_pigmentation1.86347264
29MP0008872_abnormal_physiological_respon1.83715437
30MP0003890_abnormal_embryonic-extraembry1.82173290
31MP0004130_abnormal_muscle_cell1.74978687
32MP0004742_abnormal_vestibular_system1.71183394
33MP0005253_abnormal_eye_physiology1.66196079
34MP0004043_abnormal_pH_regulation1.65467387
35MP0003183_abnormal_peptide_metabolism1.63582536
36MP0005386_behavior/neurological_phenoty1.52039730
37MP0004924_abnormal_behavior1.52039730
38MP0002938_white_spotting1.51621263
39MP0005503_abnormal_tendon_morphology1.50058426
40MP0004147_increased_porphyrin_level1.48485483
41MP0005174_abnormal_tail_pigmentation1.48162091
42MP0004133_heterotaxia1.44943811
43MP0005408_hypopigmentation1.42662013
44MP0002160_abnormal_reproductive_system1.41335882
45MP0002090_abnormal_vision1.41299288
46MP0002751_abnormal_autonomic_nervous1.41148796
47MP0003136_yellow_coat_color1.39562470
48MP0000462_abnormal_digestive_system1.37635798
49MP0005167_abnormal_blood-brain_barrier1.36871271
50MP0003879_abnormal_hair_cell1.35864051
51MP0000678_abnormal_parathyroid_gland1.35036447
52MP0002928_abnormal_bile_duct1.34688899
53MP0002638_abnormal_pupillary_reflex1.33840207
54MP0009046_muscle_twitch1.33700981
55MP0002557_abnormal_social/conspecific_i1.31287384
56MP0005645_abnormal_hypothalamus_physiol1.31056394
57MP0003045_fibrosis1.27463733
58MP0003787_abnormal_imprinting1.26844193
59MP0005075_abnormal_melanosome_morpholog1.26579385
60MP0001486_abnormal_startle_reflex1.23848242
61MP0000631_abnormal_neuroendocrine_gland1.23569578
62MP0001963_abnormal_hearing_physiology1.23452126
63MP0002067_abnormal_sensory_capabilities1.22617842
64MP0001968_abnormal_touch/_nociception1.21619020
65MP0002734_abnormal_mechanical_nocicepti1.20749994
66MP0003635_abnormal_synaptic_transmissio1.19801654
67MP0002572_abnormal_emotion/affect_behav1.19771043
68MP0000230_abnormal_systemic_arterial1.19214331
69MP0002877_abnormal_melanocyte_morpholog1.19178540
70MP0004885_abnormal_endolymph1.19006260
71MP0003950_abnormal_plasma_membrane1.18572126
72MP0001188_hyperpigmentation1.18074916
73MP0002161_abnormal_fertility/fecundity1.15182509
74MP0002229_neurodegeneration1.14221876
75MP0005266_abnormal_metabolism1.13035973
76MP0004215_abnormal_myocardial_fiber1.12984521
77MP0009745_abnormal_behavioral_response1.12813000
78MP0003634_abnormal_glial_cell1.12187530
79MP0000538_abnormal_urinary_bladder1.12000550
80MP0000778_abnormal_nervous_system1.11309921
81MP0002876_abnormal_thyroid_physiology1.10913195
82MP0004145_abnormal_muscle_electrophysio1.10266396
83MP0000681_abnormal_thyroid_gland1.09613402
84MP0000013_abnormal_adipose_tissue1.09147098
85MP0003137_abnormal_impulse_conducting1.08565102
86MP0002064_seizures1.07461939
87MP0000026_abnormal_inner_ear1.06820669
88MP0002102_abnormal_ear_morphology1.06808366
89MP0001485_abnormal_pinna_reflex1.06348701
90MP0002272_abnormal_nervous_system1.06053736
91MP0000015_abnormal_ear_pigmentation1.05266211
92MP0004270_analgesia1.04967442
93MP0002234_abnormal_pharynx_morphology1.04959620
94MP0001944_abnormal_pancreas_morphology1.03066357
95MP0002210_abnormal_sex_determination1.02171851
96MP0003172_abnormal_lysosome_physiology1.00611855
97MP0003300_gastrointestinal_ulcer1.00151602
98MP0001145_abnormal_male_reproductive1.00110098
99MP0003252_abnormal_bile_duct1.00075247
100MP0005220_abnormal_exocrine_pancreas0.99840256
101MP0008775_abnormal_heart_ventricle0.99191984
102MP0008875_abnormal_xenobiotic_pharmacok0.99167892
103MP0001177_atelectasis0.97825196
104MP0001324_abnormal_eye_pigmentation0.96931481
105MP0006276_abnormal_autonomic_nervous0.96727836
106MP0002909_abnormal_adrenal_gland0.95584126
107MP0002063_abnormal_learning/memory/cond0.94146049
108MP0002653_abnormal_ependyma_morphology0.93949891
109MP0002736_abnormal_nociception_after0.93709381
110MP0001270_distended_abdomen0.93692577
111MP0005448_abnormal_energy_balance0.93433158
112MP0002693_abnormal_pancreas_physiology0.92778765
113MP0001970_abnormal_pain_threshold0.90802255
114MP0000371_diluted_coat_color0.90160959
115MP0003119_abnormal_digestive_system0.89321325
116MP0000920_abnormal_myelination0.88642615
117MP0003937_abnormal_limbs/digits/tail_de0.88556333
118MP0002837_dystrophic_cardiac_calcinosis0.88476891
119MP0003718_maternal_effect0.87817757
120MP0002282_abnormal_trachea_morphology0.86422809
121MP0005310_abnormal_salivary_gland0.86342729
122MP0001186_pigmentation_phenotype0.85918894
123MP0005423_abnormal_somatic_nervous0.85103726
124MP0002882_abnormal_neuron_morphology0.84166506
125MP0001440_abnormal_grooming_behavior0.83920358
126MP0002168_other_aberrant_phenotype0.83903158
127MP0000653_abnormal_sex_gland0.83759092
128MP0002075_abnormal_coat/hair_pigmentati0.82174321
129MP0001502_abnormal_circadian_rhythm0.82141382
130MP0005187_abnormal_penis_morphology0.82091679
131MP0003633_abnormal_nervous_system0.81758653
132MP0003878_abnormal_ear_physiology0.81336820
133MP0005377_hearing/vestibular/ear_phenot0.81336820
134MP0002752_abnormal_somatic_nervous0.81085492
135MP0005195_abnormal_posterior_eye0.80517011
136MP0005409_darkened_coat_color0.79936152
137MP0002095_abnormal_skin_pigmentation0.79141204
138MP0002733_abnormal_thermal_nociception0.79027638
139MP0003632_abnormal_nervous_system0.78890954
140MP0005085_abnormal_gallbladder_physiolo0.78312236
141MP0003959_abnormal_lean_body0.78172808
142MP0003631_nervous_system_phenotype0.76311405
143MP0002184_abnormal_innervation0.73895835
144MP0005389_reproductive_system_phenotype0.73245834
145MP0010678_abnormal_skin_adnexa0.73175190

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.99447023
2Absent/shortened dynein arms (HP:0200106)7.99447023
3Abnormal respiratory motile cilium physiology (HP:0012261)7.86095959
4Rhinitis (HP:0012384)6.70557521
5Abnormal ciliary motility (HP:0012262)6.63258652
6Abnormal respiratory motile cilium morphology (HP:0005938)6.08736962
7Abnormal respiratory epithelium morphology (HP:0012253)6.08736962
8Chronic bronchitis (HP:0004469)5.63688965
9Genetic anticipation (HP:0003743)5.16797746
10Hyperventilation (HP:0002883)5.10741599
11Protruding tongue (HP:0010808)4.52434766
12Tubulointerstitial nephritis (HP:0001970)4.31105252
13Conjugated hyperbilirubinemia (HP:0002908)4.00409098
14Central scotoma (HP:0000603)3.84575728
15Birth length less than 3rd percentile (HP:0003561)3.83844826
16* Nephrogenic diabetes insipidus (HP:0009806)3.81640306
17Clumsiness (HP:0002312)3.73112347
18Nephronophthisis (HP:0000090)3.72356507
19Bronchiectasis (HP:0002110)3.68348815
20* Medial flaring of the eyebrow (HP:0010747)3.61594313
21Gaze-evoked nystagmus (HP:0000640)3.61073626
22Congenital stationary night blindness (HP:0007642)3.53674430
23Abnormality of the renal medulla (HP:0100957)3.28807120
24Fair hair (HP:0002286)3.26838374
25Dyschromatopsia (HP:0007641)3.24337451
26Infertility (HP:0000789)3.10941086
27Bronchitis (HP:0012387)3.07193391
28* Pancreatic fibrosis (HP:0100732)3.02675748
29* True hermaphroditism (HP:0010459)3.00485562
30Patellar aplasia (HP:0006443)2.99716283
31* Gait imbalance (HP:0002141)2.96419762
32Attenuation of retinal blood vessels (HP:0007843)2.95501522
33* Congenital primary aphakia (HP:0007707)2.92927006
34Febrile seizures (HP:0002373)2.90381589
35Abnormality of the renal collecting system (HP:0004742)2.89143132
36Inability to walk (HP:0002540)2.89031286
37Nasal polyposis (HP:0100582)2.82117996
38Type II lissencephaly (HP:0007260)2.81735620
39Large for gestational age (HP:0001520)2.80344230
40Broad-based gait (HP:0002136)2.77528169
41Hypoplastic ischia (HP:0003175)2.76930860
42Abnormality of midbrain morphology (HP:0002418)2.74495138
43Molar tooth sign on MRI (HP:0002419)2.74495138
44Termporal pattern (HP:0011008)2.73240663
45Insidious onset (HP:0003587)2.73240663
46Aplasia/Hypoplasia of the patella (HP:0006498)2.72405413
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.65482380
48Hypothermia (HP:0002045)2.64160320
49Hip dysplasia (HP:0001385)2.60041696
50Generalized hypopigmentation of hair (HP:0011358)2.57220504
51Abnormality of dentin (HP:0010299)2.57075559
52* Pancreatic cysts (HP:0001737)2.56536531
53Abnormality of the ischium (HP:0003174)2.56325814
54Abnormality of alanine metabolism (HP:0010916)2.54976861
55Hyperalaninemia (HP:0003348)2.54976861
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54976861
57Cerebellar dysplasia (HP:0007033)2.54057532
58Absent speech (HP:0001344)2.52543533
59Chronic hepatic failure (HP:0100626)2.49690878
60Progressive cerebellar ataxia (HP:0002073)2.49345984
61Tubulointerstitial abnormality (HP:0001969)2.45032416
62* Genital tract atresia (HP:0001827)2.44969145
63Chronic sinusitis (HP:0011109)2.41626340
64Progressive inability to walk (HP:0002505)2.40647705
65Abolished electroretinogram (ERG) (HP:0000550)2.36939469
66Neuroendocrine neoplasm (HP:0100634)2.34639118
67* Postaxial foot polydactyly (HP:0001830)2.33653717
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31965177
69* Vaginal atresia (HP:0000148)2.30639993
70Hypoplastic labia majora (HP:0000059)2.29999032
71Pheochromocytoma (HP:0002666)2.27546139
72Preaxial foot polydactyly (HP:0001841)2.26437661
73Decreased circulating renin level (HP:0003351)2.25793837
74Decreased central vision (HP:0007663)2.23146298
75Abnormality of the renal cortex (HP:0011035)2.21931656
76* Congenital hepatic fibrosis (HP:0002612)2.21698972
77Abnormal auditory evoked potentials (HP:0006958)2.20025120
78* Cystic liver disease (HP:0006706)2.19748088
79Breast hypoplasia (HP:0003187)2.19626832
80Congenital, generalized hypertrichosis (HP:0004540)2.18673749
81Abnormality of the labia majora (HP:0012881)2.17751931
82Occipital encephalocele (HP:0002085)2.11582631
83Keratoconus (HP:0000563)2.10223032
84Increased corneal curvature (HP:0100692)2.10223032
85Scotoma (HP:0000575)2.10163801
86Median cleft lip (HP:0000161)2.09873122
87Stomach cancer (HP:0012126)2.09169337
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.07404324
89Dysmetric saccades (HP:0000641)2.05813407
90Chorioretinal atrophy (HP:0000533)2.05534398
91Bony spicule pigmentary retinopathy (HP:0007737)2.04031832
92Abnormality of the nasal mucosa (HP:0000433)2.04015643
93Dialeptic seizures (HP:0011146)2.03769321
94Renal dysplasia (HP:0000110)2.02551475
95Progressive sensorineural hearing impairment (HP:0000408)2.02363243
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02050038
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1974531
98Macroglossia (HP:0000158)1.99486468
99Drooling (HP:0002307)1.97815227
100* Retinitis pigmentosa (HP:0000510)1.97475145
101Highly arched eyebrow (HP:0002553)1.96909897
102Duplicated collecting system (HP:0000081)1.96682302
103* Aplasia/Hypoplasia of the lens (HP:0008063)1.96560455
104Nephropathy (HP:0000112)1.96269761
105Fibular hypoplasia (HP:0003038)1.94569313
106Agitation (HP:0000713)1.93807192
107* Postaxial hand polydactyly (HP:0001162)1.92968199
108Lissencephaly (HP:0001339)1.91611654
109Abnormal biliary tract physiology (HP:0012439)1.90958333
110Bile duct proliferation (HP:0001408)1.90958333
111Small hand (HP:0200055)1.89728685
112Pendular nystagmus (HP:0012043)1.89604099
113Congenital sensorineural hearing impairment (HP:0008527)1.89230794
114* Aplasia/Hypoplasia of the tongue (HP:0010295)1.88858374
115* Poor coordination (HP:0002370)1.88507231
116Abnormality of binocular vision (HP:0011514)1.88076756
117Diplopia (HP:0000651)1.88076756
118Urinary bladder sphincter dysfunction (HP:0002839)1.88072193
119Focal seizures (HP:0007359)1.86922758
120Absence seizures (HP:0002121)1.84009040
121Increased cerebral lipofuscin (HP:0011813)1.83199890
122Visual hallucinations (HP:0002367)1.82079175
123Renal cortical cysts (HP:0000803)1.81677296
124Abnormality of the pubic bones (HP:0003172)1.79077588
125Abnormality of the pons (HP:0007361)1.78564475
126Hypoplasia of the pons (HP:0012110)1.78297996
127Renal tubular acidosis (HP:0001947)1.77857558
128Thyroid-stimulating hormone excess (HP:0002925)1.77100336
129Widely spaced teeth (HP:0000687)1.76634031
130Impaired smooth pursuit (HP:0007772)1.76610098
131Excessive salivation (HP:0003781)1.76469778
132Elevated erythrocyte sedimentation rate (HP:0003565)1.76368974
133Clubbing of toes (HP:0100760)1.75683216
134Short tibia (HP:0005736)1.75077630
135Prominent supraorbital ridges (HP:0000336)1.73714623
136* Furrowed tongue (HP:0000221)1.73526136
137Stage 5 chronic kidney disease (HP:0003774)1.73406944
138Bulbous nose (HP:0000414)1.70636768
139Hypoplastic iliac wings (HP:0002866)1.70128288
140Absent radius (HP:0003974)1.70049150
141* Specific learning disability (HP:0001328)1.69526778
142Atonic seizures (HP:0010819)1.68358966
143Hemiparesis (HP:0001269)1.67629957
144Polydipsia (HP:0001959)1.66987794
145Abnormal drinking behavior (HP:0030082)1.66987794
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66498168
147Aplasia involving forearm bones (HP:0009822)1.66487681
148Absent forearm bone (HP:0003953)1.66487681
149Cupped ear (HP:0000378)1.66446967
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.66439158
151Epileptic encephalopathy (HP:0200134)1.66052792
152Tracheomalacia (HP:0002779)1.65775847
153Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65546288
154Recurrent otitis media (HP:0000403)1.65184513
155Optic disc pallor (HP:0000543)1.64283163
156Progressive external ophthalmoplegia (HP:0000590)1.64280925
157Epileptiform EEG discharges (HP:0011182)1.64198790
158Chromsome breakage (HP:0040012)1.62994274
159Abnormality of the dental pulp (HP:0006479)1.61633752
160Abnormality of the fovea (HP:0000493)1.60611855
161Blue irides (HP:0000635)1.60566968
162Abnormality of calcium-phosphate metabolism (HP:0100530)1.59879436
163EEG with generalized epileptiform discharges (HP:0011198)1.58019123
164* Anencephaly (HP:0002323)1.57840825
165Severe visual impairment (HP:0001141)1.56453061
166Recurrent sinusitis (HP:0011108)1.56452171
167Focal motor seizures (HP:0011153)1.54520988
168Polycystic kidney dysplasia (HP:0000113)1.53200578
169Tubular atrophy (HP:0000092)1.52416019
170Aplasia/Hypoplasia of the fovea (HP:0008060)1.51687675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.81843887
2ACVR1B4.57579860
3CASK4.03102095
4NTRK33.66083744
5PDK33.46093831
6PDK43.46093831
7MAPK152.61358448
8STK392.38501856
9NUAK12.30334112
10CAMKK21.89197966
11PDK21.86603254
12ZAK1.86280500
13CDK31.83000503
14MAP2K71.80507165
15INSRR1.76546403
16MAPK131.63912308
17STK161.62774524
18TAOK31.61488358
19WNK41.59350328
20TGFBR11.57313264
21MKNK21.50331042
22TESK11.50190974
23TLK11.47354223
24PNCK1.45973513
25PLK21.45708653
26OXSR11.45122678
27HIPK21.37129289
28DYRK31.32342794
29CAMK1D1.30310214
30FES1.29988888
31LMTK21.28199768
32IRAK11.18831595
33UHMK11.17972049
34PRKCE1.17559467
35BMPR1B1.15281104
36VRK11.14386019
37BCR1.14121078
38YES11.14036160
39PRPF4B1.12346084
40MAP3K41.11996960
41STK38L1.11006635
42PINK11.08875733
43SGK2231.06862766
44SGK4941.06862766
45SGK21.06586566
46EIF2AK31.06368473
47WNK31.03992294
48TRPM71.03736249
49PIK3CA1.03015652
50PASK1.01756834
51CAMK2B0.95529154
52PIK3CG0.95070011
53MAP3K60.93831197
54BRSK10.89901767
55GRK10.89686386
56CAMK2D0.88801536
57MELK0.84065356
58MAP4K20.83155688
59FER0.81428482
60ADRBK20.80936353
61PRKD30.80667740
62MAPKAPK50.80605218
63ICK0.77326018
64STK30.77156647
65RPS6KA20.76375660
66MINK10.76260275
67TIE10.74914802
68MAP3K70.73905349
69CAMK2A0.73645033
70NEK60.73129257
71NEK20.72449243
72TXK0.72353697
73PTK2B0.70397600
74CAMKK10.70328438
75PRKCG0.70185246
76MARK10.69822019
77CAMK10.69360839
78SIK30.68792294
79OBSCN0.68004412
80CAMK1G0.67434805
81BRSK20.67148150
82PRKG10.65320264
83TEC0.64517851
84CHUK0.63754950
85BRD40.63743245
86BMPR20.61669418
87ERBB30.59453688
88EPHA40.57533668
89MAPKAPK30.57032405
90MKNK10.55678040
91ADRBK10.54542568
92MUSK0.51886849
93FRK0.51836690
94NTRK10.51763589
95ERBB20.50307414
96SIK20.50063181
97LATS10.49476316
98STK110.47825267
99FGFR20.47443492
100DYRK1B0.45839294
101NTRK20.44726951
102KIT0.44603092
103WEE10.44434093
104NLK0.43758856
105PKN10.42380068
106IRAK20.41923201
107CCNB10.41283058
108CDC42BPA0.41226563
109MAP2K10.39844341
110PRKCB0.38117399
111PRKAA10.37913103
112MAP2K60.37704252
113RPS6KA60.37359295
114CDK50.35050290
115IKBKB0.34929825
116STK380.34855992
117CDK120.34468736
118CAMK40.34279828
119PRKACA0.34184287
120PAK30.34164561
121SGK10.33438652
122PRKCH0.33357852
123DAPK20.33172029
124MAPKAPK20.32563558
125FLT30.32014380
126PRKCQ0.32002421
127CSNK1D0.31959153
128TNK20.31632040
129PLK40.31559717
130AKT30.30736110
131RPS6KA50.30172329
132CHEK20.29871640
133ATR0.29682531
134GRK70.29544442
135PRKAA20.29523506
136CDK60.29424718
137MARK30.28621648
138CDK80.28024899
139CDK190.27666433
140ITK0.27552811
141CAMK2G0.27488736
142NEK90.26714110
143MAP2K40.26128769
144EPHA30.25971502
145SGK30.24076417
146WNK10.23925429
147CDK140.23664448

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.67109581
2Protein export_Homo sapiens_hsa030603.98748085
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.99666694
4Nitrogen metabolism_Homo sapiens_hsa009102.50900844
5Butanoate metabolism_Homo sapiens_hsa006502.34430338
6Vibrio cholerae infection_Homo sapiens_hsa051102.16430216
7Taste transduction_Homo sapiens_hsa047422.15229312
8Phototransduction_Homo sapiens_hsa047442.15159734
9Insulin secretion_Homo sapiens_hsa049112.12992941
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.11787745
11Selenocompound metabolism_Homo sapiens_hsa004502.09005799
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07664601
13Tryptophan metabolism_Homo sapiens_hsa003802.03384858
14Collecting duct acid secretion_Homo sapiens_hsa049662.03333046
15Amphetamine addiction_Homo sapiens_hsa050312.03181395
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86569836
17N-Glycan biosynthesis_Homo sapiens_hsa005101.68250088
18Circadian entrainment_Homo sapiens_hsa047131.67605247
19Synaptic vesicle cycle_Homo sapiens_hsa047211.67488969
20Homologous recombination_Homo sapiens_hsa034401.63901233
21Morphine addiction_Homo sapiens_hsa050321.61718759
22Nicotine addiction_Homo sapiens_hsa050331.60687098
23Pyruvate metabolism_Homo sapiens_hsa006201.60214146
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59080649
25Renin secretion_Homo sapiens_hsa049241.56562215
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54725876
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51456467
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47804969
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45683127
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.41086184
31Olfactory transduction_Homo sapiens_hsa047401.38905719
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.37712476
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.30466100
34Dopaminergic synapse_Homo sapiens_hsa047281.29128333
35Glycerolipid metabolism_Homo sapiens_hsa005611.28909595
36Caffeine metabolism_Homo sapiens_hsa002321.28698665
37Glutamatergic synapse_Homo sapiens_hsa047241.28484110
38Glucagon signaling pathway_Homo sapiens_hsa049221.28183845
39Thyroid hormone synthesis_Homo sapiens_hsa049181.25989598
40Fatty acid elongation_Homo sapiens_hsa000621.25112624
41Ether lipid metabolism_Homo sapiens_hsa005651.21907560
42Cocaine addiction_Homo sapiens_hsa050301.21853762
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21227676
44ABC transporters_Homo sapiens_hsa020101.20750910
45Serotonergic synapse_Homo sapiens_hsa047261.20649157
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20422619
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20117091
48Phagosome_Homo sapiens_hsa041451.19393158
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16079680
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15987179
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12507378
52Lysine degradation_Homo sapiens_hsa003101.12141090
53GABAergic synapse_Homo sapiens_hsa047271.11322100
54Sphingolipid metabolism_Homo sapiens_hsa006001.10594431
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07383161
56Cholinergic synapse_Homo sapiens_hsa047251.05192628
57Long-term potentiation_Homo sapiens_hsa047201.04874247
58Linoleic acid metabolism_Homo sapiens_hsa005911.03468864
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.03286801
60Chemical carcinogenesis_Homo sapiens_hsa052041.01692684
61Rheumatoid arthritis_Homo sapiens_hsa053231.01604052
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98814248
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98305591
64Oxidative phosphorylation_Homo sapiens_hsa001900.97543301
65Alcoholism_Homo sapiens_hsa050340.95084526
66Retinol metabolism_Homo sapiens_hsa008300.91641388
67Huntingtons disease_Homo sapiens_hsa050160.89867388
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89433259
69Calcium signaling pathway_Homo sapiens_hsa040200.89069419
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88996931
71Fatty acid biosynthesis_Homo sapiens_hsa000610.88743052
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87700110
73Arachidonic acid metabolism_Homo sapiens_hsa005900.86379471
74Salivary secretion_Homo sapiens_hsa049700.84663292
75beta-Alanine metabolism_Homo sapiens_hsa004100.84367682
76Alzheimers disease_Homo sapiens_hsa050100.79280276
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77355067
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.77315872
79cAMP signaling pathway_Homo sapiens_hsa040240.76335252
80Fanconi anemia pathway_Homo sapiens_hsa034600.75881960
81Circadian rhythm_Homo sapiens_hsa047100.72341070
82Gastric acid secretion_Homo sapiens_hsa049710.72315576
83Peroxisome_Homo sapiens_hsa041460.68300876
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68176345
85Estrogen signaling pathway_Homo sapiens_hsa049150.67260378
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64298450
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64044224
88Type I diabetes mellitus_Homo sapiens_hsa049400.62311677
89Type II diabetes mellitus_Homo sapiens_hsa049300.62186078
90Axon guidance_Homo sapiens_hsa043600.62116190
91Tyrosine metabolism_Homo sapiens_hsa003500.61274834
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61103129
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60642700
94Mineral absorption_Homo sapiens_hsa049780.57532272
95Graft-versus-host disease_Homo sapiens_hsa053320.56974805
96Asthma_Homo sapiens_hsa053100.56862004
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.56183046
98Bile secretion_Homo sapiens_hsa049760.55710331
99Melanogenesis_Homo sapiens_hsa049160.54126137
100Dorso-ventral axis formation_Homo sapiens_hsa043200.53754363
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53752624
102Propanoate metabolism_Homo sapiens_hsa006400.53718921
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53313487
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52620559
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52501453
106One carbon pool by folate_Homo sapiens_hsa006700.51872920
107Lysosome_Homo sapiens_hsa041420.51539377
108Regulation of autophagy_Homo sapiens_hsa041400.49775860
109Pancreatic secretion_Homo sapiens_hsa049720.48639347
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47731853
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45356712
112MAPK signaling pathway_Homo sapiens_hsa040100.44738614
113Long-term depression_Homo sapiens_hsa047300.42502621
114Purine metabolism_Homo sapiens_hsa002300.42112445
115TGF-beta signaling pathway_Homo sapiens_hsa043500.41896557
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41217173
117Basal transcription factors_Homo sapiens_hsa030220.40064419
118Renin-angiotensin system_Homo sapiens_hsa046140.39321603
119Melanoma_Homo sapiens_hsa052180.39297963
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39207657
121Platelet activation_Homo sapiens_hsa046110.38625294
122Hedgehog signaling pathway_Homo sapiens_hsa043400.38253699
123Wnt signaling pathway_Homo sapiens_hsa043100.38214384
124Fat digestion and absorption_Homo sapiens_hsa049750.38205839
125Ovarian steroidogenesis_Homo sapiens_hsa049130.38186859
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37588952
127RNA polymerase_Homo sapiens_hsa030200.37382769
128FoxO signaling pathway_Homo sapiens_hsa040680.35991437
129Oxytocin signaling pathway_Homo sapiens_hsa049210.35874911
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35725523
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31878889
132Hippo signaling pathway_Homo sapiens_hsa043900.31641010
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31633308
134Ras signaling pathway_Homo sapiens_hsa040140.31306531
135Glioma_Homo sapiens_hsa052140.30751481
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30242214
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29963698
138Histidine metabolism_Homo sapiens_hsa003400.29735635
139Vitamin B6 metabolism_Homo sapiens_hsa007500.29215934
140Oocyte meiosis_Homo sapiens_hsa041140.28973823
141Cardiac muscle contraction_Homo sapiens_hsa042600.28516938
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28516065
143Other glycan degradation_Homo sapiens_hsa005110.28433602
144Inositol phosphate metabolism_Homo sapiens_hsa005620.27725798

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