WDFY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.95125548
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.95125548
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.95125548
4modulation by symbiont of host immune response (GO:0052553)6.95125548
5positive regulation by symbiont of host defense response (GO:0052509)6.95125548
6modulation by symbiont of host defense response (GO:0052031)6.95125548
7regulation of interferon-beta biosynthetic process (GO:0045357)5.76236194
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.30440429
9macrophage activation involved in immune response (GO:0002281)5.01272050
10positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.77638098
11response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.63113184
12response to host immune response (GO:0052572)4.63113184
13positive regulation of interferon-alpha production (GO:0032727)4.58656484
14neutrophil activation involved in immune response (GO:0002283)4.53575981
15interkinetic nuclear migration (GO:0022027)4.49883683
16regulation of interferon-alpha production (GO:0032647)4.39364164
17negative regulation of translation, ncRNA-mediated (GO:0040033)4.31860958
18regulation of translation, ncRNA-mediated (GO:0045974)4.31860958
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.31860958
20response to host (GO:0075136)4.22372269
21response to host defenses (GO:0052200)4.22372269
22response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.22372269
23response to peptidoglycan (GO:0032494)4.13954532
24microglial cell activation (GO:0001774)3.96674164
25positive regulation of gamma-delta T cell activation (GO:0046645)3.94792219
26respiratory burst (GO:0045730)3.93832906
27immunoglobulin mediated immune response (GO:0016064)3.80236395
28cellular extravasation (GO:0045123)3.73578644
29neutrophil mediated immunity (GO:0002446)3.71793502
30I-kappaB phosphorylation (GO:0007252)3.69254960
31myeloid cell activation involved in immune response (GO:0002275)3.64129540
32positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.61546507
33response to muramyl dipeptide (GO:0032495)3.60848543
34regulation of gene silencing by RNA (GO:0060966)3.57418227
35regulation of posttranscriptional gene silencing (GO:0060147)3.57418227
36regulation of gene silencing by miRNA (GO:0060964)3.57418227
37regulation of cholesterol storage (GO:0010885)3.54101682
38pinocytosis (GO:0006907)3.51734392
39positive regulation of interferon-beta production (GO:0032728)3.49013585
40phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.47938631
41natural killer cell mediated cytotoxicity (GO:0042267)3.43764525
42natural killer cell mediated immunity (GO:0002228)3.43764525
43detection of other organism (GO:0098543)3.39717419
44macrophage activation (GO:0042116)3.38127983
45neutrophil activation (GO:0042119)3.35761623
46granulocyte activation (GO:0036230)3.34137892
47regulation of B cell receptor signaling pathway (GO:0050855)3.33694673
48activated T cell proliferation (GO:0050798)3.32116852
49neural tube formation (GO:0001841)3.30225359
50definitive hemopoiesis (GO:0060216)3.28456200
51regulation of interleukin-8 biosynthetic process (GO:0045414)3.25695074
52detection of bacterium (GO:0016045)3.23578131
53positive regulation of B cell differentiation (GO:0045579)3.21270452
54negative thymic T cell selection (GO:0045060)3.20782669
55histone H3-K4 trimethylation (GO:0080182)3.19694040
56mannose metabolic process (GO:0006013)3.18637151
57positive regulation of granulocyte differentiation (GO:0030854)3.16679681
58negative T cell selection (GO:0043383)3.16080664
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.13815042
60pyrimidine dimer repair (GO:0006290)3.13474888
61detection of external biotic stimulus (GO:0098581)3.09721187
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08872571
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08872571
64negative regulation of lipid storage (GO:0010888)3.08113721
65low-density lipoprotein particle clearance (GO:0034383)3.05970400
66positive regulation of developmental pigmentation (GO:0048087)3.05290454
67antigen processing and presentation of endogenous antigen (GO:0019883)3.04097705
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04054288
69detection of biotic stimulus (GO:0009595)3.03246524
70cell adhesion mediated by integrin (GO:0033627)3.00466913
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99954468
72apoptotic cell clearance (GO:0043277)2.99665664
73positive regulation of antigen processing and presentation (GO:0002579)2.99567190
74negative regulation of T cell mediated immunity (GO:0002710)2.97553787
75positive regulation of mast cell activation involved in immune response (GO:0033008)2.94469482
76positive regulation of mast cell degranulation (GO:0043306)2.94469482
77lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93903256
78regulation of interleukin-12 biosynthetic process (GO:0045075)2.93173028
79negative regulation of interleukin-12 production (GO:0032695)2.93047529
80positive regulation of cellular amide metabolic process (GO:0034250)2.93041179
81negative regulation of interleukin-17 production (GO:0032700)2.84276664
82histone H3-K9 methylation (GO:0051567)2.83800156
83detection of molecule of bacterial origin (GO:0032490)2.83743072
84cell proliferation in forebrain (GO:0021846)2.83167244
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79857298
86positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78851668
87regulation of interferon-beta production (GO:0032648)2.78607749
88regulation of gamma-delta T cell activation (GO:0046643)2.78223151
89myeloid leukocyte mediated immunity (GO:0002444)2.78060354
90positive T cell selection (GO:0043368)2.76420281
91histone H3-K9 modification (GO:0061647)2.75884849
92positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75797479
93negative regulation of granulocyte differentiation (GO:0030853)2.75763036
94negative regulation of cell killing (GO:0031342)2.74934247
95negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74934247
96interferon-gamma production (GO:0032609)2.74576061
97B cell mediated immunity (GO:0019724)2.74310482
98regulation of interleukin-6 biosynthetic process (GO:0045408)2.74302461
99regulation of interferon-gamma biosynthetic process (GO:0045072)2.71049767
100response to lipoprotein particle (GO:0055094)2.70266759
101positive thymic T cell selection (GO:0045059)2.69606362
102leukocyte mediated cytotoxicity (GO:0001909)2.68562891
103response to fungus (GO:0009620)2.66995393
104histone H3-K36 demethylation (GO:0070544)2.65979268
105T-helper 1 type immune response (GO:0042088)2.65381090
106adaptation of signaling pathway (GO:0023058)2.64284954
107leukocyte aggregation (GO:0070486)2.63931086
108negative regulation of cAMP-mediated signaling (GO:0043951)2.63348949
109myeloid leukocyte activation (GO:0002274)2.61657024
110production of molecular mediator involved in inflammatory response (GO:0002532)2.61289875
111negative regulation of B cell mediated immunity (GO:0002713)2.61062342
112negative regulation of immunoglobulin mediated immune response (GO:0002890)2.61062342
113mast cell activation (GO:0045576)2.60815893
114regulation of mast cell degranulation (GO:0043304)2.59770629
115regulation of gamma-delta T cell differentiation (GO:0045586)2.59753778
116modification by symbiont of host morphology or physiology (GO:0044003)2.59153606
117regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.58879791
118positive regulation of mast cell activation (GO:0033005)2.58255555
119regulation of B cell differentiation (GO:0045577)2.56578369
120negative regulation of interleukin-1 beta production (GO:0032691)2.56556640
121defense response to protozoan (GO:0042832)2.55998475
122positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.55410149
123negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.55135645
124response to interleukin-15 (GO:0070672)2.55068593
125positive regulation of macrophage cytokine production (GO:0060907)2.54745659
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54551297
127regulation of mononuclear cell migration (GO:0071675)2.54182212
128negative regulation of erythrocyte differentiation (GO:0045647)2.53549904
129regulation of pigment cell differentiation (GO:0050932)2.52212779
130JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.51965887
131regulation of mast cell activation (GO:0033003)2.51633167
132response to laminar fluid shear stress (GO:0034616)2.51404136
133negative regulation of B cell proliferation (GO:0030889)2.51101575
134response to type I interferon (GO:0034340)2.50621324
135regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49417733
136positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49417733
137regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49187487
138B cell receptor signaling pathway (GO:0050853)2.48941400
139cellular response to type I interferon (GO:0071357)2.48456305
140type I interferon signaling pathway (GO:0060337)2.48456305
141NIK/NF-kappaB signaling (GO:0038061)2.47759359
142cell wall macromolecule catabolic process (GO:0016998)2.47664632
143leukocyte cell-cell adhesion (GO:0007159)2.46994664
144regulation of MHC class II biosynthetic process (GO:0045346)2.46968920
145cellular response to exogenous dsRNA (GO:0071360)2.46733048
146protein K11-linked deubiquitination (GO:0035871)2.46686835
147T cell migration (GO:0072678)2.46163757
148cytokine secretion (GO:0050663)2.45513715
149germinal center formation (GO:0002467)2.45431135
150regulation of leukocyte degranulation (GO:0043300)2.45247620
151cilium or flagellum-dependent cell motility (GO:0001539)2.45164000
152regulation of mast cell activation involved in immune response (GO:0033006)2.44714118
153protein K48-linked deubiquitination (GO:0071108)2.43915497
154mRNA splice site selection (GO:0006376)2.43735856
155negative regulation of adaptive immune response (GO:0002820)2.40441656
156negative regulation of leukocyte mediated immunity (GO:0002704)2.40130765
157positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.39645010
158positive regulation of tolerance induction (GO:0002645)2.39512527
159regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.39311897
160negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.38905488
161cytoplasmic mRNA processing body assembly (GO:0033962)2.38645194
162regulation of non-canonical Wnt signaling pathway (GO:2000050)2.38408886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.52293819
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.37243457
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.46459846
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.96187665
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.90568656
6* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56134082
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.43966591
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30695479
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22237191
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.21715626
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.08465288
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.98493780
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96989263
14* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87538233
15ZNF274_21170338_ChIP-Seq_K562_Hela2.82010646
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80768699
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.72888790
18* SALL1_21062744_ChIP-ChIP_HESCs_Human2.63676696
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49814085
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.48154237
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42047401
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37464103
23E2F7_22180533_ChIP-Seq_HELA_Human2.36920248
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35223405
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.28989544
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19609710
27VDR_21846776_ChIP-Seq_THP-1_Human2.19220216
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14019146
29TAF15_26573619_Chip-Seq_HEK293_Human2.10737669
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05632918
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.02459621
32EZH2_22144423_ChIP-Seq_EOC_Human2.02456963
33SPI1_23547873_ChIP-Seq_NB4_Human1.99049355
34FUS_26573619_Chip-Seq_HEK293_Human1.98285694
35GBX2_23144817_ChIP-Seq_PC3_Human1.98235924
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97744885
37SCL_19346495_ChIP-Seq_HPC-7_Human1.96776470
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96345046
39VDR_24763502_ChIP-Seq_THP-1_Human1.94535912
40* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91955623
41SPI1_23127762_ChIP-Seq_K562_Human1.91325730
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85153798
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.83579158
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82130210
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78666874
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.78666874
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.75103498
48* PU_27001747_Chip-Seq_BMDM_Mouse1.74024466
49MYB_26560356_Chip-Seq_TH2_Human1.71656542
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69255658
51MAF_26560356_Chip-Seq_TH1_Human1.68809025
52VDR_22108803_ChIP-Seq_LS180_Human1.67092475
53AR_21572438_ChIP-Seq_LNCaP_Human1.66762730
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66532511
55* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66082019
56RUNX_20019798_ChIP-Seq_JUKART_Human1.66014227
57EWS_26573619_Chip-Seq_HEK293_Human1.65483826
58MYB_26560356_Chip-Seq_TH1_Human1.61077086
59* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61043413
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60648676
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59806242
62* P300_19829295_ChIP-Seq_ESCs_Human1.59471491
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.59033451
64STAT3_23295773_ChIP-Seq_U87_Human1.57247409
65ER_23166858_ChIP-Seq_MCF-7_Human1.54884323
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53553424
67MYC_22102868_ChIP-Seq_BL_Human1.53381395
68VDR_24787735_ChIP-Seq_THP-1_Human1.50926023
69TCF7_22412390_ChIP-Seq_EML_Mouse1.50533457
70TP53_16413492_ChIP-PET_HCT116_Human1.50425070
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49726614
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48646709
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46628950
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46496577
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45622120
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.45081689
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44640585
78RXR_22108803_ChIP-Seq_LS180_Human1.43759064
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43097129
80* LXR_22158963_ChIP-Seq_LIVER_Mouse1.42378532
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.42069558
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41930238
83IRF1_19129219_ChIP-ChIP_H3396_Human1.39277588
84* RXR_22158963_ChIP-Seq_LIVER_Mouse1.39268284
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38712033
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37679657
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35297003
88* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35112914
89UTX_26944678_Chip-Seq_JUKART_Human1.34392988
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33389736
91SMAD4_21799915_ChIP-Seq_A2780_Human1.32835655
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32831416
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32349757
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.32048596
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31924853
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31643272
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30882673
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30333450
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28510555
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26744733
101IGF1R_20145208_ChIP-Seq_DFB_Human1.24464037
102GATA1_22025678_ChIP-Seq_K562_Human1.24067560
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22082220
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21369079
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20440809
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18725777
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18544779
108BCAT_22108803_ChIP-Seq_LS180_Human1.18377489
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18125934
110TCF4_23295773_ChIP-Seq_U87_Human1.17690765
111RUNX2_22187159_ChIP-Seq_PCA_Human1.15401140
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.14802250
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14584086
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.14441035
115KDM2B_26808549_Chip-Seq_DND41_Human1.13837421
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.13448752
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13391151
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.12799014
119CBP_20019798_ChIP-Seq_JUKART_Human1.12775228
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12775228
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11503583
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.11152939
123GATA3_27048872_Chip-Seq_THYMUS_Human1.09225408
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09026645
125CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08317394
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07394209
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06836396
128TFEB_21752829_ChIP-Seq_HELA_Human1.05478245
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04978398
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04647541
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.02317068
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02164510
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.01809924
134TCF4_22108803_ChIP-Seq_LS180_Human1.00859862
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00800150
136NFE2_27457419_Chip-Seq_LIVER_Mouse1.00527187
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00433041
138EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00138654
139* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00081126
140CLOCK_20551151_ChIP-Seq_293T_Human0.99881333
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99772493
142AR_25329375_ChIP-Seq_VCAP_Human0.99400587
143PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99190649
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99045868
145GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98650937
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98368592
147* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97240194
148* ARNT_22903824_ChIP-Seq_MCF-7_Human0.96884346
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96183963
150* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96078657
151SMRT_27268052_Chip-Seq_Bcells_Human0.96065072
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95771979
153* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94869588
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.94822505
155* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94621211
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93776924
157THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93349022
158GATA1_19941826_ChIP-Seq_K562_Human0.89577322
159SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89070606
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89070606
161GATA3_26560356_Chip-Seq_TH2_Human0.86954480
162* GATA2_19941826_ChIP-Seq_K562_Human0.86925965
163MAF_26560356_Chip-Seq_TH2_Human0.86031079
164RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82710702
165LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82236820
166BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81029786
167TP63_17297297_ChIP-ChIP_HaCaT_Human0.80850840
168PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80849134
169GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80290475
170FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79438442
171* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77336102
172NCOR1_26117541_ChIP-Seq_K562_Human0.75576628
173P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73372149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.76140641
2MP0001835_abnormal_antigen_presentation3.46598244
3MP0000569_abnormal_digit_pigmentation3.38577761
4MP0003787_abnormal_imprinting3.33207264
5MP0003436_decreased_susceptibility_to3.31082787
6MP0005058_abnormal_lysosome_morphology3.28238666
7MP0006292_abnormal_olfactory_placode3.19866239
8MP0008877_abnormal_DNA_methylation2.82812446
9MP0002419_abnormal_innate_immunity2.76234656
10MP0009840_abnormal_foam_cell2.72999621
11MP0003172_abnormal_lysosome_physiology2.72785275
12MP0006082_CNS_inflammation2.64232769
13MP0008057_abnormal_DNA_replication2.51611808
14MP0005000_abnormal_immune_tolerance2.46233780
15MP0003191_abnormal_cellular_cholesterol2.37597405
16MP0002452_abnormal_antigen_presenting2.30057195
17MP0003300_gastrointestinal_ulcer2.27656752
18MP0005025_abnormal_response_to2.24822589
19MP0001800_abnormal_humoral_immune2.24756083
20MP0003878_abnormal_ear_physiology2.24743999
21MP0005377_hearing/vestibular/ear_phenot2.24743999
22MP0001790_abnormal_immune_system2.23397249
23MP0005387_immune_system_phenotype2.23397249
24MP0009785_altered_susceptibility_to2.16614655
25MP0005464_abnormal_platelet_physiology2.13736035
26MP0010307_abnormal_tumor_latency2.13326696
27MP0003195_calcinosis2.06463659
28MP0009278_abnormal_bone_marrow2.05374004
29MP0002723_abnormal_immune_serum2.05014788
30MP0002928_abnormal_bile_duct2.00913242
31MP0000685_abnormal_immune_system2.00227554
32MP0003122_maternal_imprinting1.94947353
33MP0001533_abnormal_skeleton_physiology1.91324796
34MP0002148_abnormal_hypersensitivity_rea1.90246360
35MP0005076_abnormal_cell_differentiation1.89594145
36MP0005075_abnormal_melanosome_morpholog1.88402283
37MP0003121_genomic_imprinting1.88308167
38MP0001819_abnormal_immune_cell1.85855929
39MP0002420_abnormal_adaptive_immunity1.84322758
40MP0004947_skin_inflammation1.83434308
41MP0003183_abnormal_peptide_metabolism1.83047154
42MP0004510_myositis1.82901569
43MP0005671_abnormal_response_to1.73373791
44MP0003705_abnormal_hypodermis_morpholog1.72685037
45MP0009379_abnormal_foot_pigmentation1.67906678
46MP0003690_abnormal_glial_cell1.62157616
47MP0000604_amyloidosis1.56903809
48MP0002405_respiratory_system_inflammati1.53213246
49MP0001845_abnormal_inflammatory_respons1.53113622
50MP0005257_abnormal_intraocular_pressure1.52641167
51MP0002095_abnormal_skin_pigmentation1.49377067
52MP0010352_gastrointestinal_tract_polyps1.49109345
53MP0004142_abnormal_muscle_tone1.48879970
54MP0003566_abnormal_cell_adhesion1.46395159
55MP0001986_abnormal_taste_sensitivity1.45868369
56MP0005551_abnormal_eye_electrophysiolog1.45467233
57MP0002166_altered_tumor_susceptibility1.43958350
58MP0002009_preneoplasia1.42132146
59MP0003448_altered_tumor_morphology1.41762202
60MP0000716_abnormal_immune_system1.41206625
61MP0004133_heterotaxia1.40359524
62MP0002396_abnormal_hematopoietic_system1.39645122
63MP0008469_abnormal_protein_level1.39634213
64MP0003252_abnormal_bile_duct1.37126441
65MP0005397_hematopoietic_system_phenotyp1.36939566
66MP0001545_abnormal_hematopoietic_system1.36939566
67MP0000343_altered_response_to1.36768877
68MP0002398_abnormal_bone_marrow1.35900634
69MP0003763_abnormal_thymus_physiology1.34726740
70MP0000689_abnormal_spleen_morphology1.34645729
71MP0002653_abnormal_ependyma_morphology1.34422670
72MP0003724_increased_susceptibility_to1.33662476
73MP0008438_abnormal_cutaneous_collagen1.33114063
74MP0008995_early_reproductive_senescence1.32373579
75MP0010155_abnormal_intestine_physiology1.32260444
76MP0005174_abnormal_tail_pigmentation1.31151011
77MP0003943_abnormal_hepatobiliary_system1.28229764
78MP0001851_eye_inflammation1.27438410
79MP0006072_abnormal_retinal_apoptosis1.27277542
80MP0010234_abnormal_vibrissa_follicle1.26808312
81MP0003075_altered_response_to1.26402877
82MP0001853_heart_inflammation1.25962831
83MP0000465_gastrointestinal_hemorrhage1.24707931
84MP0005084_abnormal_gallbladder_morpholo1.23004670
85MP0000631_abnormal_neuroendocrine_gland1.21926931
86MP0005310_abnormal_salivary_gland1.18807115
87MP0002006_tumorigenesis1.18385801
88MP0004885_abnormal_endolymph1.16805382
89MP0002429_abnormal_blood_cell1.16728041
90MP0004883_abnormal_blood_vessel1.16043914
91MP0003890_abnormal_embryonic-extraembry1.15547736
92MP0002722_abnormal_immune_system1.14977982
93MP0003091_abnormal_cell_migration1.14781920
94MP0004808_abnormal_hematopoietic_stem1.14416971
95MP0000858_altered_metastatic_potential1.11436873
96MP0009764_decreased_sensitivity_to1.06666775
97MP0002277_abnormal_respiratory_mucosa1.06142339
98MP0002998_abnormal_bone_remodeling1.05688765
99MP0005253_abnormal_eye_physiology1.04188914
100MP0004130_abnormal_muscle_cell1.03138341
101MP0000371_diluted_coat_color1.02826938
102MP0003136_yellow_coat_color0.99106068
103MP0009763_increased_sensitivity_to0.98997373
104MP0005166_decreased_susceptibility_to0.98038054
105MP0003045_fibrosis0.97749592
106MP0000427_abnormal_hair_cycle0.97425420
107MP0001915_intracranial_hemorrhage0.97402414
108MP0001293_anophthalmia0.96910334
109MP0000609_abnormal_liver_physiology0.95228865
110MP0002163_abnormal_gland_morphology0.93601064
111MP0005645_abnormal_hypothalamus_physiol0.92548876
112MP0000383_abnormal_hair_follicle0.92330120
113MP0009333_abnormal_splenocyte_physiolog0.91191528
114MP0003453_abnormal_keratinocyte_physiol0.91050446
115MP0005023_abnormal_wound_healing0.90752616
116MP0005083_abnormal_biliary_tract0.88066959
117MP0005390_skeleton_phenotype0.87953343
118MP0000015_abnormal_ear_pigmentation0.86768832
119MP0001486_abnormal_startle_reflex0.85603383
120MP0003656_abnormal_erythrocyte_physiolo0.85164548
121MP0005360_urolithiasis0.84241375
122MP0001873_stomach_inflammation0.84225069
123MP0006276_abnormal_autonomic_nervous0.81425201
124MP0005389_reproductive_system_phenotype0.80425697
125MP0005220_abnormal_exocrine_pancreas0.80381127
126MP0003828_pulmonary_edema0.78080967
127MP0002139_abnormal_hepatobiliary_system0.77550554
128MP0002933_joint_inflammation0.76479084
129MP0004134_abnormal_chest_morphology0.75874357
130MP0009765_abnormal_xenobiotic_induced0.75286378
131MP0008961_abnormal_basal_metabolism0.74750639
132MP0001286_abnormal_eye_development0.74087355
133MP0000598_abnormal_liver_morphology0.72658126
134MP0001485_abnormal_pinna_reflex0.72260521
135MP0002160_abnormal_reproductive_system0.72134575
136MP0003567_abnormal_fetal_cardiomyocyte0.71260164
137MP0000733_abnormal_muscle_development0.71209592
138MP0002254_reproductive_system_inflammat0.71018985
139MP0000778_abnormal_nervous_system0.70981368
140MP0000767_abnormal_smooth_muscle0.70838431
141MP0002938_white_spotting0.70725817
142MP0005195_abnormal_posterior_eye0.70157605
143MP0004742_abnormal_vestibular_system0.69918436
144MP0005621_abnormal_cell_physiology0.68899087
145MP0005164_abnormal_response_to0.68881460
146MP0008260_abnormal_autophagy0.68759034
147MP0000920_abnormal_myelination0.68687275
148MP0005167_abnormal_blood-brain_barrier0.68169580
149MP0001501_abnormal_sleep_pattern0.68086597
150MP0003283_abnormal_digestive_organ0.67883523
151MP0005451_abnormal_body_composition0.67815712
152MP0000703_abnormal_thymus_morphology0.66988416
153MP0000490_abnormal_crypts_of0.66606188
154MP0005379_endocrine/exocrine_gland_phen0.65737308
155MP0001958_emphysema0.64448480
156MP0005197_abnormal_uvea_morphology0.64411255
157MP0004043_abnormal_pH_regulation0.64303064
158MP0002822_catalepsy0.63107477
159MP0003646_muscle_fatigue0.62972157

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.98638541
2Recurrent bacterial skin infections (HP:0005406)5.65529464
3Eczematoid dermatitis (HP:0000976)5.34174184
4Recurrent gram-negative bacterial infections (HP:0005420)5.14652563
5Increased cerebral lipofuscin (HP:0011813)4.59174532
6Abnormality of macrophages (HP:0004311)4.09214875
7Vacuolated lymphocytes (HP:0001922)4.00004565
8Systemic lupus erythematosus (HP:0002725)3.78517649
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.77109037
10Recurrent skin infections (HP:0001581)3.63308809
11Myocardial infarction (HP:0001658)3.39790733
12Gingivitis (HP:0000230)3.39538868
13Mediastinal lymphadenopathy (HP:0100721)3.37655211
14Recurrent fungal infections (HP:0002841)3.36900525
15Genetic anticipation (HP:0003743)3.36890967
16Hematochezia (HP:0002573)3.15326123
17Acute lymphatic leukemia (HP:0006721)3.09924446
18Recurrent viral infections (HP:0004429)3.08518937
19Pancreatic fibrosis (HP:0100732)3.06485688
20Myositis (HP:0100614)3.05221581
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.03915763
22Abnormality of glycolipid metabolism (HP:0010969)3.03915763
23Abnormality of liposaccharide metabolism (HP:0010968)3.03915763
24Periodontitis (HP:0000704)3.03099946
25Diastasis recti (HP:0001540)2.99611147
26Autoimmune thrombocytopenia (HP:0001973)2.98985712
27Pancreatic cysts (HP:0001737)2.96467463
28Dysostosis multiplex (HP:0000943)2.93538867
29Prostate neoplasm (HP:0100787)2.92267626
30Osteolytic defects of the hand bones (HP:0009699)2.84401773
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.84401773
32Thick nail (HP:0001805)2.84278133
33Axonal loss (HP:0003447)2.82603557
34Obstructive lung disease (HP:0006536)2.82299998
35Chronic obstructive pulmonary disease (HP:0006510)2.82299998
36True hermaphroditism (HP:0010459)2.81856196
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.77401815
38Orchitis (HP:0100796)2.75304818
39Cellulitis (HP:0100658)2.74863639
40Elevated erythrocyte sedimentation rate (HP:0003565)2.73692689
41Disinhibition (HP:0000734)2.73001939
42Stomatitis (HP:0010280)2.70993670
43Abolished electroretinogram (ERG) (HP:0000550)2.67822394
44Vasculitis (HP:0002633)2.61671020
45Glomerulonephritis (HP:0000099)2.60374718
46Attenuation of retinal blood vessels (HP:0007843)2.59615507
47Stomach cancer (HP:0012126)2.57802240
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57334845
49Nephronophthisis (HP:0000090)2.57160357
50Optic neuritis (HP:0100653)2.56754752
51Retrobulbar optic neuritis (HP:0100654)2.56754752
52Hypochromic microcytic anemia (HP:0004840)2.55127415
53Urinary glycosaminoglycan excretion (HP:0003541)2.54982438
54Mucopolysacchariduria (HP:0008155)2.54982438
55Pustule (HP:0200039)2.54550617
56Broad alveolar ridges (HP:0000187)2.52587890
57Abnormality of the renal medulla (HP:0100957)2.51483118
58Agnosia (HP:0010524)2.51148765
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50049506
60Abnormality of polysaccharide metabolism (HP:0011012)2.50049506
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50049506
62Increased CSF protein (HP:0002922)2.48111701
63Panhypogammaglobulinemia (HP:0003139)2.45659928
64Upper motor neuron abnormality (HP:0002127)2.45296251
65Chronic hepatic failure (HP:0100626)2.44581844
66Widely spaced teeth (HP:0000687)2.39115884
67Recurrent cutaneous fungal infections (HP:0011370)2.38306027
68Chronic mucocutaneous candidiasis (HP:0002728)2.38306027
69Loss of speech (HP:0002371)2.37884157
70Congenital stationary night blindness (HP:0007642)2.35468073
71Arterial thrombosis (HP:0004420)2.35260393
72Peripheral demyelination (HP:0011096)2.35107048
73Colitis (HP:0002583)2.34406145
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33055140
75Hypoplastic iliac wings (HP:0002866)2.31630129
76Supernumerary bones of the axial skeleton (HP:0009144)2.31084101
77Progressive cerebellar ataxia (HP:0002073)2.30591301
78Supernumerary ribs (HP:0005815)2.28968658
79Osteomyelitis (HP:0002754)2.28347846
80Joint hemorrhage (HP:0005261)2.27866293
81Leukocytosis (HP:0001974)2.27156092
82Clumsiness (HP:0002312)2.26887561
83Cerebral aneurysm (HP:0004944)2.26014949
84Gingival bleeding (HP:0000225)2.25565193
85Acute myeloid leukemia (HP:0004808)2.21563774
86Hepatoblastoma (HP:0002884)2.19556499
87Protruding tongue (HP:0010808)2.19290046
88Hepatosplenomegaly (HP:0001433)2.18005540
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16460731
90Complement deficiency (HP:0004431)2.14811004
91Eosinophilia (HP:0001880)2.12296112
92Abnormality of complement system (HP:0005339)2.10462912
93Urticaria (HP:0001025)2.08564389
94Decreased central vision (HP:0007663)2.08421407
95Nephritis (HP:0000123)2.08256159
96Encephalitis (HP:0002383)2.07715787
97Spontaneous hematomas (HP:0007420)2.07508156
98Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07428802
99Inflammation of the large intestine (HP:0002037)2.06845938
100Meningitis (HP:0001287)2.05008264
101Pathologic fracture (HP:0002756)2.04855939
102Gaze-evoked nystagmus (HP:0000640)2.04425190
103Urethral obstruction (HP:0000796)2.04411370
104Abnormality of DNA repair (HP:0003254)2.03999115
105Abnormality of the pubic bones (HP:0003172)2.01781973
106Cystic liver disease (HP:0006706)2.01767394
107Basal ganglia calcification (HP:0002135)2.00178378
108Abnormality of midbrain morphology (HP:0002418)1.99351840
109Molar tooth sign on MRI (HP:0002419)1.99351840
110Abnormality of the axillary hair (HP:0100134)1.95817892
111Abnormality of secondary sexual hair (HP:0009888)1.95817892
112Abnormality of the nasal septum (HP:0000419)1.95661890
113Prolonged bleeding time (HP:0003010)1.95373107
114Gastrointestinal inflammation (HP:0004386)1.94971075
115T lymphocytopenia (HP:0005403)1.93223078
116Pulmonary infiltrates (HP:0002113)1.92580880
117Keratoconjunctivitis (HP:0001096)1.92074796
118Dynein arm defect of respiratory motile cilia (HP:0012255)1.89513392
119Absent/shortened dynein arms (HP:0200106)1.89513392
120Abnormality of the wing of the ilium (HP:0011867)1.87928264
121Albinism (HP:0001022)1.87612341
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87387173
123Short 4th metacarpal (HP:0010044)1.87387173
124Thrombocytosis (HP:0001894)1.86596489
125Abnormality of the prostate (HP:0008775)1.85528559
126Amyloidosis (HP:0011034)1.84588250
127Submucous cleft hard palate (HP:0000176)1.84120885
128Restrictive lung disease (HP:0002091)1.83663477
129Abnormality of T cell number (HP:0011839)1.83615273
130Conjunctival telangiectasia (HP:0000524)1.82614887
131Growth hormone deficiency (HP:0000824)1.82519587
132Medial flaring of the eyebrow (HP:0010747)1.81577092
133Abnormality of the parietal bone (HP:0002696)1.81420563
134Agammaglobulinemia (HP:0004432)1.79615852
135Metaphyseal dysplasia (HP:0100255)1.78911097
136Bone pain (HP:0002653)1.78677675
137Oligodactyly (hands) (HP:0001180)1.77792612
138Hemiplegia (HP:0002301)1.77083668
139Segmental peripheral demyelination/remyelination (HP:0003481)1.76352116
140Thickened calvaria (HP:0002684)1.75793619
141Abnormality of the thoracic spine (HP:0100711)1.75348381
142Abnormal rod and cone electroretinograms (HP:0008323)1.75340956
143Interstitial pulmonary disease (HP:0006530)1.75215092
144Thoracic kyphosis (HP:0002942)1.75074086
145Anencephaly (HP:0002323)1.74585939
146Postaxial foot polydactyly (HP:0001830)1.73372800
147Macular degeneration (HP:0000608)1.73004146
148Papillary thyroid carcinoma (HP:0002895)1.72830375
149Peritonitis (HP:0002586)1.72391579
150Congenital hepatic fibrosis (HP:0002612)1.72150536
151Keratoconjunctivitis sicca (HP:0001097)1.71298334
152Hypochromic anemia (HP:0001931)1.71017454
153Severe visual impairment (HP:0001141)1.69912637
154Intestinal atresia (HP:0011100)1.69449498
155Abnormality of the renal cortex (HP:0011035)1.68035687
156Abnormality of the lumbar spine (HP:0100712)1.67732071
157Gastrointestinal stroma tumor (HP:0100723)1.67204264
158Emphysema (HP:0002097)1.67005172
159Hemoptysis (HP:0002105)1.66811205
160Hip dysplasia (HP:0001385)1.66305573
161Granulocytopenia (HP:0001913)1.66278024
162Epistaxis (HP:0000421)1.66040759
163Neonatal respiratory distress (HP:0002643)1.65524671
164Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65401657
165Cupped ear (HP:0000378)1.65107396
166Skin ulcer (HP:0200042)1.65059383
167Fair hair (HP:0002286)1.64684271
168Neoplasm of the tracheobronchial system (HP:0100552)1.63672913
169Chest pain (HP:0100749)1.63034761
170Amyotrophic lateral sclerosis (HP:0007354)1.61955703
171Subacute progressive viral hepatitis (HP:0006572)1.61786713
172Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61758619
173Gastrointestinal infarctions (HP:0005244)1.61561383
174Persistence of primary teeth (HP:0006335)1.61309692
175Bilateral microphthalmos (HP:0007633)1.59795945
176Decreased circulating renin level (HP:0003351)1.58696365
177Increased IgE level (HP:0003212)1.58566801
178Pendular nystagmus (HP:0012043)1.57744914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.01345813
2TYK22.88996305
3MAP3K142.79639180
4BLK2.66106823
5KIT2.65903182
6RIPK42.50815876
7CSF1R2.48687732
8TAOK32.24722490
9TRIB32.22418230
10TBK12.21056504
11IRAK32.18784460
12IRAK42.14092579
13ERN12.08003238
14BRD42.07361831
15JAK12.06479632
16EPHB12.02156518
17CAMK1D2.01774721
18JAK31.99599576
19AKT31.98824032
20MAP3K101.95850666
21PTK61.90893165
22SIK11.88881282
23TGFBR21.87847543
24TTN1.84226700
25CDK191.73855368
26STK101.73385612
27PKN21.72273596
28MAP3K61.64724290
29IKBKE1.51545090
30IKBKB1.51245771
31BTK1.47922246
32HCK1.45639103
33CDK121.43626063
34ACVR1B1.42120366
35BMPR1B1.40825709
36MKNK11.40742966
37PIK3CG1.40097731
38NUAK11.39683357
39CSK1.34954254
40ZAP701.31185396
41MKNK21.30546120
42CAMK1G1.29973852
43FES1.28508540
44TNK21.27909045
45SCYL21.26680493
46CHUK1.24803519
47FLT31.23736457
48MAP3K41.20946018
49FGFR21.20701913
50SIK21.20086021
51SGK21.19989488
52IRAK11.18476882
53MAP3K131.15556980
54NEK91.12971336
55JAK21.12156379
56STK111.11465404
57FGFR41.11395740
58LCK1.10820105
59PAK41.10018935
60MAP2K31.09838485
61TXK1.08608032
62TNIK1.08033607
63STK41.07513247
64WNK31.07477014
65CDK61.07295106
66EEF2K1.06024226
67MARK31.05763053
68SYK1.04877930
69STK31.02974357
70MAP3K71.01871992
71FGFR31.00109165
72PIM10.97750255
73RIPK10.93928932
74WNK10.92903244
75PIK3CA0.92742077
76FGR0.90426946
77MAPK150.90385333
78NLK0.89810075
79DYRK1A0.89532270
80NTRK30.88209811
81LRRK20.88208967
82ITK0.87104983
83BMX0.86761712
84MARK20.85142155
85LYN0.84925585
86SGK4940.83660772
87SGK2230.83660772
88DYRK1B0.80789240
89MAP2K40.79229375
90PBK0.78855266
91FRK0.77271687
92MATK0.76656919
93GRK70.75665480
94EGFR0.75276585
95TRPM70.71766473
96NEK20.70735830
97RPS6KA40.70010004
98ADRBK10.68698582
99MAPK130.68637567
100ABL10.68135482
101ADRBK20.67233349
102TGFBR10.66124723
103PDGFRB0.64246524
104CLK10.64050542
105TESK20.63894537
106INSRR0.61682371
107CAMKK20.60936624
108MAP4K20.60390018
109ZAK0.59509334
110NTRK20.59372548
111TEC0.58676517
112YES10.57168421
113TYRO30.56605700
114MAPK70.55923210
115MAP2K20.54592045
116SGK10.54506750
117MAP3K30.52884701
118PTK2B0.52877663
119MAP3K80.51964268
120PRKCQ0.51179205
121RET0.51144615
122DYRK30.50019296
123MTOR0.49470405
124ALK0.49001981
125TAF10.48292441
126CDK30.47977656
127RPS6KA20.46925348
128CAMK40.46831902
129HIPK20.45236028
130STK38L0.45205445
131GSK3A0.45140378
132PDK10.44617902
133SGK30.43105247
134GRK60.40217113
135SIK30.39128848
136PKN10.38585553
137FYN0.37282649
138PIM20.36307087
139EPHA30.36028634
140PDPK10.35814511
141ERBB20.35620667
142EIF2AK20.34160782
143NTRK10.28705753
144PAK20.28657423
145IGF1R0.28529349
146RPS6KA60.28496073
147ABL20.28020564
148SRC0.27115951
149MAP3K50.26995088
150PRKCD0.26972415
151MELK0.25574741
152INSR0.25122370
153PRKD10.24835352

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.10553095
2Leishmaniasis_Homo sapiens_hsa051402.83343565
3Osteoclast differentiation_Homo sapiens_hsa043802.44428747
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.43326899
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.29422893
6B cell receptor signaling pathway_Homo sapiens_hsa046622.25824995
7Lysosome_Homo sapiens_hsa041422.25557831
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.14675231
9Tuberculosis_Homo sapiens_hsa051521.96115506
10Malaria_Homo sapiens_hsa051441.92799535
11Pertussis_Homo sapiens_hsa051331.83281812
12Legionellosis_Homo sapiens_hsa051341.83142574
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77851073
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75039259
15Measles_Homo sapiens_hsa051621.74826196
16Dorso-ventral axis formation_Homo sapiens_hsa043201.73280473
17Toxoplasmosis_Homo sapiens_hsa051451.68633446
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68548683
19Other glycan degradation_Homo sapiens_hsa005111.68416631
20Influenza A_Homo sapiens_hsa051641.58294848
21Phototransduction_Homo sapiens_hsa047441.53514642
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52686444
23Phagosome_Homo sapiens_hsa041451.51378748
24TNF signaling pathway_Homo sapiens_hsa046681.51143743
25Apoptosis_Homo sapiens_hsa042101.49643964
26Complement and coagulation cascades_Homo sapiens_hsa046101.45103110
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43623552
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42479819
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42345505
30Ether lipid metabolism_Homo sapiens_hsa005651.41953430
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40562619
32Linoleic acid metabolism_Homo sapiens_hsa005911.38731779
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.34014394
34Antigen processing and presentation_Homo sapiens_hsa046121.32162804
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29333178
36Chronic myeloid leukemia_Homo sapiens_hsa052201.27834084
37Taste transduction_Homo sapiens_hsa047421.27472918
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26366174
39Hematopoietic cell lineage_Homo sapiens_hsa046401.25951505
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25606299
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23848926
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.23716593
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19870887
44Caffeine metabolism_Homo sapiens_hsa002321.18868009
45Hepatitis B_Homo sapiens_hsa051611.18570662
46Herpes simplex infection_Homo sapiens_hsa051681.16435731
47Autoimmune thyroid disease_Homo sapiens_hsa053201.14842992
48Long-term depression_Homo sapiens_hsa047301.11927743
49Small cell lung cancer_Homo sapiens_hsa052221.10465928
50Hepatitis C_Homo sapiens_hsa051601.10152716
51Chemokine signaling pathway_Homo sapiens_hsa040621.09155768
52Rheumatoid arthritis_Homo sapiens_hsa053231.08721395
53Shigellosis_Homo sapiens_hsa051311.08656320
54Viral myocarditis_Homo sapiens_hsa054161.08001538
55Amoebiasis_Homo sapiens_hsa051461.07810334
56Acute myeloid leukemia_Homo sapiens_hsa052211.06527085
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.03464420
58Salmonella infection_Homo sapiens_hsa051321.02495456
59Pancreatic cancer_Homo sapiens_hsa052121.00770640
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00532154
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98744443
62Graft-versus-host disease_Homo sapiens_hsa053320.98153064
63Allograft rejection_Homo sapiens_hsa053300.95651654
64Type I diabetes mellitus_Homo sapiens_hsa049400.94486749
65Fanconi anemia pathway_Homo sapiens_hsa034600.94471687
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93821993
67T cell receptor signaling pathway_Homo sapiens_hsa046600.92363160
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.91846261
69Insulin resistance_Homo sapiens_hsa049310.90353678
70Regulation of autophagy_Homo sapiens_hsa041400.89359835
71Renin secretion_Homo sapiens_hsa049240.88315353
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87338117
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87125896
74Arachidonic acid metabolism_Homo sapiens_hsa005900.86817303
75Primary immunodeficiency_Homo sapiens_hsa053400.86608708
76ABC transporters_Homo sapiens_hsa020100.85922454
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85797950
78Choline metabolism in cancer_Homo sapiens_hsa052310.85492661
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84575909
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.83029606
81Type II diabetes mellitus_Homo sapiens_hsa049300.83009891
82Ovarian steroidogenesis_Homo sapiens_hsa049130.83000037
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82488073
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79151283
85Glutamatergic synapse_Homo sapiens_hsa047240.78188930
86Serotonergic synapse_Homo sapiens_hsa047260.77873892
87Viral carcinogenesis_Homo sapiens_hsa052030.75933652
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75927226
89mTOR signaling pathway_Homo sapiens_hsa041500.75709250
90Morphine addiction_Homo sapiens_hsa050320.74857343
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.74598599
92MAPK signaling pathway_Homo sapiens_hsa040100.74560856
93Platelet activation_Homo sapiens_hsa046110.73729466
94African trypanosomiasis_Homo sapiens_hsa051430.72037057
95Lysine degradation_Homo sapiens_hsa003100.71871580
96Homologous recombination_Homo sapiens_hsa034400.71003593
97Non-small cell lung cancer_Homo sapiens_hsa052230.70598036
98Oxytocin signaling pathway_Homo sapiens_hsa049210.70534046
99Asthma_Homo sapiens_hsa053100.69527796
100Selenocompound metabolism_Homo sapiens_hsa004500.68919372
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68256494
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.67829961
103Inositol phosphate metabolism_Homo sapiens_hsa005620.66289677
104Proteoglycans in cancer_Homo sapiens_hsa052050.65652235
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.65513229
106Epstein-Barr virus infection_Homo sapiens_hsa051690.65382565
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.65281365
108Olfactory transduction_Homo sapiens_hsa047400.65004212
109Prolactin signaling pathway_Homo sapiens_hsa049170.64754306
110Salivary secretion_Homo sapiens_hsa049700.63960277
111Cholinergic synapse_Homo sapiens_hsa047250.63694565
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63211700
113Circadian entrainment_Homo sapiens_hsa047130.62983000
114MicroRNAs in cancer_Homo sapiens_hsa052060.62202140
115Calcium signaling pathway_Homo sapiens_hsa040200.62200933
116Basal cell carcinoma_Homo sapiens_hsa052170.61794805
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60743304
118Nitrogen metabolism_Homo sapiens_hsa009100.57559784
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57526033
120Ras signaling pathway_Homo sapiens_hsa040140.57223743
121Renal cell carcinoma_Homo sapiens_hsa052110.57156951
122Steroid biosynthesis_Homo sapiens_hsa001000.56167650
123GnRH signaling pathway_Homo sapiens_hsa049120.55235007
124Circadian rhythm_Homo sapiens_hsa047100.55001760
125PPAR signaling pathway_Homo sapiens_hsa033200.54985572
126cAMP signaling pathway_Homo sapiens_hsa040240.54711416
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54673740
128Notch signaling pathway_Homo sapiens_hsa043300.53929166
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.53781398
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.50786948
131Focal adhesion_Homo sapiens_hsa045100.50636661
132HIF-1 signaling pathway_Homo sapiens_hsa040660.50524841
133Prostate cancer_Homo sapiens_hsa052150.50198507
134One carbon pool by folate_Homo sapiens_hsa006700.50072770
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49199034
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48634107
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.48514835
138VEGF signaling pathway_Homo sapiens_hsa043700.48463532
139Endocytosis_Homo sapiens_hsa041440.48160361
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47861953
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47461711
142Endometrial cancer_Homo sapiens_hsa052130.46551117
143Glycerolipid metabolism_Homo sapiens_hsa005610.46504046
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46303206
145Arginine biosynthesis_Homo sapiens_hsa002200.46207224
146Colorectal cancer_Homo sapiens_hsa052100.46166254
147FoxO signaling pathway_Homo sapiens_hsa040680.46062471
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.45998013
149Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45195997
150Prion diseases_Homo sapiens_hsa050200.44403475
151HTLV-I infection_Homo sapiens_hsa051660.42527255
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41746644

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