WBSCR27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.29259794
2ribosomal small subunit assembly (GO:0000028)6.72519578
3motile cilium assembly (GO:0044458)6.63829220
4cilium or flagellum-dependent cell motility (GO:0001539)6.09470335
5cilium movement (GO:0003341)5.77756857
6viral transcription (GO:0019083)5.34707284
7epithelial cilium movement (GO:0003351)5.19501010
8translational termination (GO:0006415)5.07791716
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.78619811
10cotranslational protein targeting to membrane (GO:0006613)4.68853903
11protein maturation by protein folding (GO:0022417)4.66869289
12platelet dense granule organization (GO:0060155)4.65982245
13protein targeting to ER (GO:0045047)4.64684154
14translational elongation (GO:0006414)4.58989175
15protein localization to endoplasmic reticulum (GO:0070972)4.41929697
16Golgi transport vesicle coating (GO:0048200)4.41643963
17COPI coating of Golgi vesicle (GO:0048205)4.41643963
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.41377463
19L-phenylalanine metabolic process (GO:0006558)4.41377463
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.36938732
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.28975300
22ribosomal small subunit biogenesis (GO:0042274)4.18273870
23viral life cycle (GO:0019058)3.99605771
24primary alcohol catabolic process (GO:0034310)3.94954779
25left/right pattern formation (GO:0060972)3.94764452
26regulation of cilium movement (GO:0003352)3.85725533
27pteridine-containing compound biosynthetic process (GO:0042559)3.83808092
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.79969209
29L-phenylalanine catabolic process (GO:0006559)3.79969209
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79828758
31cellular protein complex disassembly (GO:0043624)3.78407070
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.76306593
33translational initiation (GO:0006413)3.74272551
34protein retention in ER lumen (GO:0006621)3.73143705
35ribosomal large subunit biogenesis (GO:0042273)3.71700587
36definitive hemopoiesis (GO:0060216)3.71064839
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.66213556
38maturation of SSU-rRNA (GO:0030490)3.61178034
39mitotic nuclear envelope reassembly (GO:0007084)3.56039325
40nuclear envelope reassembly (GO:0031468)3.56039325
41axoneme assembly (GO:0035082)3.55411042
42intraciliary transport (GO:0042073)3.45603651
43establishment of apical/basal cell polarity (GO:0035089)3.39140986
44hydrogen peroxide catabolic process (GO:0042744)3.38157153
45DNA deamination (GO:0045006)3.30847205
46protein complex disassembly (GO:0043241)3.27794941
47regulation of mitochondrial translation (GO:0070129)3.16844341
48proline biosynthetic process (GO:0006561)3.16522251
49formation of translation preinitiation complex (GO:0001731)3.15987289
50endosome to melanosome transport (GO:0035646)3.15464912
51endosome to pigment granule transport (GO:0043485)3.15464912
52antigen processing and presentation via MHC class Ib (GO:0002475)3.14133273
53base-excision repair, AP site formation (GO:0006285)3.14048525
54daunorubicin metabolic process (GO:0044597)3.13452980
55polyketide metabolic process (GO:0030638)3.13452980
56doxorubicin metabolic process (GO:0044598)3.13452980
57vitamin transmembrane transport (GO:0035461)3.13380835
58negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.13315800
59translation (GO:0006412)3.11372484
60endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.11229358
61macromolecular complex disassembly (GO:0032984)3.09039911
62iron-sulfur cluster assembly (GO:0016226)3.08049044
63metallo-sulfur cluster assembly (GO:0031163)3.08049044
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02858064
65GDP-mannose metabolic process (GO:0019673)2.99311430
66lung epithelium development (GO:0060428)2.98534868
67nuclear-transcribed mRNA catabolic process (GO:0000956)2.96324543
68establishment of integrated proviral latency (GO:0075713)2.95576982
69protein targeting to membrane (GO:0006612)2.95294608
70ribonucleoprotein complex biogenesis (GO:0022613)2.94848010
71lipopolysaccharide biosynthetic process (GO:0009103)2.94244437
72mature B cell differentiation involved in immune response (GO:0002313)2.93883424
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92411816
74aromatic amino acid family catabolic process (GO:0009074)2.91992359
75nucleoside diphosphate phosphorylation (GO:0006165)2.91477942
76respiratory chain complex IV assembly (GO:0008535)2.91022523
77purine-containing compound salvage (GO:0043101)2.90497791
78glutathione derivative metabolic process (GO:1901685)2.90367568
79glutathione derivative biosynthetic process (GO:1901687)2.90367568
80negative regulation of T cell differentiation in thymus (GO:0033085)2.90255677
81sulfur amino acid catabolic process (GO:0000098)2.86494475
82regulation of lipoprotein particle clearance (GO:0010984)2.84184174
83mRNA catabolic process (GO:0006402)2.81758101
84phospholipid scrambling (GO:0017121)2.81674855
85regulation of metalloenzyme activity (GO:0048552)2.80514822
86cysteine metabolic process (GO:0006534)2.79699629
87drug transport (GO:0015893)2.79011565
88proteasome assembly (GO:0043248)2.77440957
89desmosome organization (GO:0002934)2.75270917
90guanosine-containing compound biosynthetic process (GO:1901070)2.75199638
91pentose metabolic process (GO:0019321)2.72331521
92GTP biosynthetic process (GO:0006183)2.72258979
93pseudouridine synthesis (GO:0001522)2.72138725
94establishment of viral latency (GO:0019043)2.71943366
95regulation of cellular amino acid metabolic process (GO:0006521)2.71650286
96toxin transport (GO:1901998)2.71502988
97response to xenobiotic stimulus (GO:0009410)2.71299731
98nucleoside salvage (GO:0043174)2.71104783
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70363075
100RNA catabolic process (GO:0006401)2.69041976
101response to interferon-beta (GO:0035456)2.68599010
102purine nucleobase biosynthetic process (GO:0009113)2.68468048
103ethanol metabolic process (GO:0006067)2.67146913
104UTP biosynthetic process (GO:0006228)2.66729970
105ncRNA 3-end processing (GO:0043628)2.66294829
106cellular component biogenesis (GO:0044085)2.65879579
107pteridine-containing compound metabolic process (GO:0042558)2.65789524
108drug transmembrane transport (GO:0006855)2.65769439
109nucleotide salvage (GO:0043173)2.64738128
110cellular metabolic compound salvage (GO:0043094)2.64486707
111amyloid precursor protein catabolic process (GO:0042987)2.63312367
112aromatic amino acid family metabolic process (GO:0009072)2.62728024
113C-terminal protein lipidation (GO:0006501)2.61390556
114regulation of autophagic vacuole assembly (GO:2000785)2.60362515
115regulation of type B pancreatic cell apoptotic process (GO:2000674)2.60115612
116NADP metabolic process (GO:0006739)2.60024052
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59375495
118virion assembly (GO:0019068)2.58840099
119branched-chain amino acid catabolic process (GO:0009083)2.57992962
120glycine metabolic process (GO:0006544)2.57981397
121amino acid salvage (GO:0043102)2.57095155
122L-methionine salvage (GO:0071267)2.57095155
123L-methionine biosynthetic process (GO:0071265)2.57095155
124positive regulation of receptor biosynthetic process (GO:0010870)2.55895364
125glutathione biosynthetic process (GO:0006750)2.55348949
126regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.55099724
127regulation of vacuole organization (GO:0044088)2.54912777
128pyrimidine-containing compound transmembrane transport (GO:0072531)2.52695606
129N-acetylneuraminate metabolic process (GO:0006054)2.52188612
130nucleobase biosynthetic process (GO:0046112)2.52014000
131nonribosomal peptide biosynthetic process (GO:0019184)2.50247449
132UTP metabolic process (GO:0046051)2.50056428
133folic acid metabolic process (GO:0046655)2.49901592
134regulation of translational fidelity (GO:0006450)2.49884260
135tricarboxylic acid cycle (GO:0006099)2.48229425
136antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.47717992
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.47717992
138imidazole-containing compound metabolic process (GO:0052803)2.47647968
139nucleotide-sugar biosynthetic process (GO:0009226)2.47213504
140establishment or maintenance of monopolar cell polarity (GO:0061339)2.47137451
141establishment of monopolar cell polarity (GO:0061162)2.47137451
142pyridine nucleotide biosynthetic process (GO:0019363)2.47119832
143nicotinamide nucleotide biosynthetic process (GO:0019359)2.47119832
144L-fucose catabolic process (GO:0042355)2.46601214
145fucose catabolic process (GO:0019317)2.46601214
146L-fucose metabolic process (GO:0042354)2.46601214
147deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46521176
148telomere maintenance via telomerase (GO:0007004)2.46248419
149signal peptide processing (GO:0006465)2.45453376
1504-hydroxyproline metabolic process (GO:0019471)2.45194202
151aldehyde catabolic process (GO:0046185)2.44968456
152viral protein processing (GO:0019082)2.44540623
153negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43974526
154ventricular system development (GO:0021591)2.43658598
155deoxyribose phosphate biosynthetic process (GO:0046385)2.43586264
1562-deoxyribonucleotide biosynthetic process (GO:0009265)2.43586264
157negative regulation of transcription by competitive promoter binding (GO:0010944)2.43290861
158peptidyl-histidine modification (GO:0018202)2.42400647
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.41748425
160RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.41748425
161secretory granule organization (GO:0033363)2.41742848
162retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41584083
163mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41181361
164nucleobase-containing small molecule interconversion (GO:0015949)2.40146767
165protoporphyrinogen IX metabolic process (GO:0046501)2.40128039
166cellular aldehyde metabolic process (GO:0006081)2.39999622
167response to nitrosative stress (GO:0051409)2.39724273
168purine nucleotide salvage (GO:0032261)2.39027905
169proline metabolic process (GO:0006560)2.38486811
170positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.37175352
171protein autoprocessing (GO:0016540)2.36859981
172ER overload response (GO:0006983)2.36558896
173pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.36078887
174nucleoside diphosphate metabolic process (GO:0009132)2.35580268
175heme biosynthetic process (GO:0006783)2.35443215
176dopamine transport (GO:0015872)2.35162078
177glucose catabolic process (GO:0006007)2.34992939
178positive regulation of respiratory burst (GO:0060267)2.33833372
179protoporphyrinogen IX biosynthetic process (GO:0006782)2.33614365
180serine family amino acid metabolic process (GO:0009069)2.33394308
181aminoglycoside antibiotic metabolic process (GO:0030647)2.32838027
182urate metabolic process (GO:0046415)2.32264880
183pyrimidine nucleotide catabolic process (GO:0006244)2.32052226
184deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.31534330
185NAD biosynthetic process (GO:0009435)2.28417195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.83994592
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.41840335
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32658192
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.28993020
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88056152
6E2F7_22180533_ChIP-Seq_HELA_Human2.85783106
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.82442273
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80666376
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78671268
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66390945
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.61343723
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.46295437
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42096406
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.41437814
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36852097
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.33482769
17SCL_19346495_ChIP-Seq_HPC-7_Human2.30385968
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30033529
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.25818487
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21240598
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17733210
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14706068
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.13428789
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.13393682
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12440900
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08694463
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.03926302
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03374674
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02565958
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01608571
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.00906629
32VDR_23849224_ChIP-Seq_CD4+_Human2.00610505
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98612617
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95357960
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95093933
36RACK7_27058665_Chip-Seq_MCF-7_Human1.94511717
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93767586
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.90068207
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89004581
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86343709
41FOXP3_21729870_ChIP-Seq_TREG_Human1.85069092
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.84494488
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84215986
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77823810
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76414800
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75840655
47XRN2_22483619_ChIP-Seq_HELA_Human1.74062877
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71737893
49DCP1A_22483619_ChIP-Seq_HELA_Human1.66071988
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.65322837
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65288964
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64741884
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64563688
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58665377
55LXR_22292898_ChIP-Seq_THP-1_Human1.58359752
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56077105
57GABP_19822575_ChIP-Seq_HepG2_Human1.55447992
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.55191128
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53890551
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53622964
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.53478563
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52714737
63* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52487228
64ATF3_27146783_Chip-Seq_COLON_Human1.51935641
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49879561
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47646114
67ZNF263_19887448_ChIP-Seq_K562_Human1.46242540
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45525206
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44667536
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44596529
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.42133050
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41555011
73TTF2_22483619_ChIP-Seq_HELA_Human1.41550226
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41447844
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41293092
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40826722
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39090139
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38868004
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37805998
80GATA1_22025678_ChIP-Seq_K562_Human1.37732559
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33137476
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33022342
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32437944
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.32183370
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30477191
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30184947
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28855407
88TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.28649624
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26827174
90* P68_20966046_ChIP-Seq_HELA_Human1.26813071
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26793049
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.26102154
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25616084
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24816530
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23991773
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23806533
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23779838
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21922783
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.20817876
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20748250
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20446178
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20196645
103LXR_22158963_ChIP-Seq_LIVER_Mouse1.19858403
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19669012
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18782837
106* FOXP1_21924763_ChIP-Seq_HESCs_Human1.18466087
107MYC_22102868_ChIP-Seq_BL_Human1.18218295
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17305917
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16922256
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16632565
111SPI1_23547873_ChIP-Seq_NB4_Human1.16381813
112TP53_22127205_ChIP-Seq_IMR90_Human1.16059704
113TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15771730
114ELK1_19687146_ChIP-ChIP_HELA_Human1.15557500
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13843746
116SMC4_20622854_ChIP-Seq_HELA_Human1.13667186
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13441697
118CIITA_25753668_ChIP-Seq_RAJI_Human1.13211740
119ESR1_21235772_ChIP-Seq_MCF-7_Human1.11995582
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.11969374
121E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11200620
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10534722
123P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09117659
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08401534
125RARB_24833708_ChIP-Seq_LIVER_Mouse1.06702331
126VDR_21846776_ChIP-Seq_THP-1_Human1.06166043
127ELF5_23300383_ChIP-Seq_T47D_Human1.05878953
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05737297
129SOX2_20726797_ChIP-Seq_SW620_Human1.05099346
130ELF1_20517297_ChIP-Seq_JURKAT_Human1.04635185
131PHF8_20622854_ChIP-Seq_HELA_Human1.03045267
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02369619
133MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01400088
134SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01054796
135KDM5A_27292631_Chip-Seq_BREAST_Human1.00358846
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99265391
137TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98926677
138* BCOR_27268052_Chip-Seq_Bcells_Human0.98925930
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98880693
140TFEB_21752829_ChIP-Seq_HELA_Human0.98738794
141FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98625699
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98607510
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.98298829
144IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98061501
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97941106
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97845600
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97548721
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97305533
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95286067
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88341123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.50311285
2MP0002139_abnormal_hepatobiliary_system4.37933064
3MP0005365_abnormal_bile_salt3.38941235
4MP0003806_abnormal_nucleotide_metabolis2.99912962
5MP0005085_abnormal_gallbladder_physiolo2.96761836
6MP0010030_abnormal_orbit_morphology2.87144677
7MP0005451_abnormal_body_composition2.78853213
8MP0005360_urolithiasis2.71979524
9MP0003186_abnormal_redox_activity2.71732399
10MP0009379_abnormal_foot_pigmentation2.58408448
11MP0008875_abnormal_xenobiotic_pharmacok2.52653456
12MP0009780_abnormal_chondrocyte_physiolo2.38638709
13MP0003656_abnormal_erythrocyte_physiolo2.31259557
14MP0004133_heterotaxia2.26236407
15MP0005083_abnormal_biliary_tract2.22612795
16MP0003724_increased_susceptibility_to2.22202557
17MP0009840_abnormal_foam_cell2.10453024
18MP0003693_abnormal_embryo_hatching2.04243875
19MP0005397_hematopoietic_system_phenotyp1.96798347
20MP0001545_abnormal_hematopoietic_system1.96798347
21MP0001348_abnormal_lacrimal_gland1.94204557
22MP0004272_abnormal_basement_membrane1.91302988
23MP0010329_abnormal_lipoprotein_level1.88638316
24MP0010678_abnormal_skin_adnexa1.85802502
25MP0002796_impaired_skin_barrier1.84913618
26MP0001764_abnormal_homeostasis1.84516482
27MP0006036_abnormal_mitochondrial_physio1.84096688
28MP0004147_increased_porphyrin_level1.83160384
29MP0002653_abnormal_ependyma_morphology1.82236825
30MP0000465_gastrointestinal_hemorrhage1.80258203
31MP0008260_abnormal_autophagy1.78216219
32MP0002254_reproductive_system_inflammat1.76312744
33MP0005501_abnormal_skin_physiology1.74512899
34MP0002396_abnormal_hematopoietic_system1.74434270
35MP0005075_abnormal_melanosome_morpholog1.71333949
36MP0001666_abnormal_nutrient_absorption1.70794008
37MP0001986_abnormal_taste_sensitivity1.69830958
38MP0005332_abnormal_amino_acid1.60932390
39MP0004957_abnormal_blastocyst_morpholog1.57689382
40MP0003453_abnormal_keratinocyte_physiol1.57197953
41MP0001849_ear_inflammation1.54683306
42MP0008004_abnormal_stomach_pH1.54181676
43MP0009384_cardiac_valve_regurgitation1.51745268
44MP0009643_abnormal_urine_homeostasis1.51598395
45MP0005319_abnormal_enzyme/_coenzyme1.51331290
46MP0004808_abnormal_hematopoietic_stem1.49590982
47MP0009697_abnormal_copulation1.45884950
48MP0003252_abnormal_bile_duct1.44813051
49MP0005464_abnormal_platelet_physiology1.44692962
50MP0005084_abnormal_gallbladder_morpholo1.43368385
51MP0003868_abnormal_feces_composition1.42892665
52MP0000609_abnormal_liver_physiology1.42329074
53MP0001881_abnormal_mammary_gland1.41772863
54MP0002138_abnormal_hepatobiliary_system1.41188204
55MP0008789_abnormal_olfactory_epithelium1.40988371
56MP0002877_abnormal_melanocyte_morpholog1.40687923
57MP0003077_abnormal_cell_cycle1.40637712
58MP0005220_abnormal_exocrine_pancreas1.36739513
59MP0003123_paternal_imprinting1.35971820
60MP0005257_abnormal_intraocular_pressure1.35859317
61MP0002909_abnormal_adrenal_gland1.33280820
62MP0003566_abnormal_cell_adhesion1.32790835
63MP0003111_abnormal_nucleus_morphology1.32534807
64MP0003866_abnormal_defecation1.28757286
65MP0000685_abnormal_immune_system1.28472152
66MP0010094_abnormal_chromosome_stability1.27584384
67MP0005165_increased_susceptibility_to1.27483222
68MP0002060_abnormal_skin_morphology1.25237990
69MP0004858_abnormal_nervous_system1.23726398
70MP0009765_abnormal_xenobiotic_induced1.23535615
71MP0002132_abnormal_respiratory_system1.23463315
72MP0002163_abnormal_gland_morphology1.23022083
73MP0001661_extended_life_span1.22575981
74MP0000598_abnormal_liver_morphology1.22492396
75MP0009785_altered_susceptibility_to1.21739774
76MP0005377_hearing/vestibular/ear_phenot1.21371141
77MP0003878_abnormal_ear_physiology1.21371141
78MP0006292_abnormal_olfactory_placode1.20756706
79MP0004264_abnormal_extraembryonic_tissu1.20006534
80MP0000490_abnormal_crypts_of1.19873588
81MP0008872_abnormal_physiological_respon1.17894622
82MP0000467_abnormal_esophagus_morphology1.17593973
83MP0005636_abnormal_mineral_homeostasis1.17435214
84MP0004019_abnormal_vitamin_homeostasis1.17139751
85MP0005174_abnormal_tail_pigmentation1.16129615
86MP0010352_gastrointestinal_tract_polyps1.12262635
87MP0005058_abnormal_lysosome_morphology1.12061282
88MP0003195_calcinosis1.11643690
89MP0010386_abnormal_urinary_bladder1.09055340
90MP0008469_abnormal_protein_level1.08954628
91MP0002118_abnormal_lipid_homeostasis1.08161177
92MP0005023_abnormal_wound_healing1.07813746
93MP0000372_irregular_coat_pigmentation1.05370043
94MP0000627_abnormal_mammary_gland1.04829153
95MP0001835_abnormal_antigen_presentation1.03812749
96MP0001756_abnormal_urination1.03060401
97MP0002095_abnormal_skin_pigmentation1.02465328
98MP0002166_altered_tumor_susceptibility1.02344116
99MP0003191_abnormal_cellular_cholesterol1.02162962
100MP0005584_abnormal_enzyme/coenzyme_acti1.00556600
101MP0003786_premature_aging1.00384840
102MP0003718_maternal_effect0.98573787
103MP0000858_altered_metastatic_potential0.98074202
104MP0002928_abnormal_bile_duct0.97458956
105MP0006072_abnormal_retinal_apoptosis0.97331845
106MP0010368_abnormal_lymphatic_system0.97292768
107MP0008007_abnormal_cellular_replicative0.96882005
108MP0006035_abnormal_mitochondrial_morpho0.96720165
109MP0005310_abnormal_salivary_gland0.94943518
110MP0000689_abnormal_spleen_morphology0.94935441
111MP0002638_abnormal_pupillary_reflex0.94474257
112MP0010155_abnormal_intestine_physiology0.94108582
113MP0004233_abnormal_muscle_weight0.94065066
114MP0002938_white_spotting0.93474678
115MP0003763_abnormal_thymus_physiology0.92818379
116MP0002722_abnormal_immune_system0.91155275
117MP0008058_abnormal_DNA_repair0.90640954
118MP0001873_stomach_inflammation0.90168798
119MP0003943_abnormal_hepatobiliary_system0.89863406
120MP0000678_abnormal_parathyroid_gland0.89823327
121MP0010771_integument_phenotype0.88921827
122MP0003705_abnormal_hypodermis_morpholog0.88236679
123MP0000358_abnormal_cell_content/0.88178953
124MP0005248_abnormal_Harderian_gland0.88150158
125MP0002098_abnormal_vibrissa_morphology0.88096216
126MP0000313_abnormal_cell_death0.87769466
127MP0001944_abnormal_pancreas_morphology0.87687897
128MP0002398_abnormal_bone_marrow0.86942694
129MP0005025_abnormal_response_to0.86517495
130MP0002295_abnormal_pulmonary_circulatio0.86394707
131MP0001984_abnormal_olfaction0.85641780
132MP0005499_abnormal_olfactory_system0.83561898
133MP0005394_taste/olfaction_phenotype0.83561898
134MP0000751_myopathy0.82231981
135MP0005408_hypopigmentation0.81782222
136MP0000762_abnormal_tongue_morphology0.81769634
137MP0005623_abnormal_meninges_morphology0.80260053
138MP0005379_endocrine/exocrine_gland_phen0.79864428
139MP0005266_abnormal_metabolism0.79793131
140MP0002429_abnormal_blood_cell0.79384089
141MP0009763_increased_sensitivity_to0.79245595
142MP0008932_abnormal_embryonic_tissue0.78976105
143MP0003638_abnormal_response/metabolism_0.78750845
144MP0002019_abnormal_tumor_incidence0.78639197
145MP0001216_abnormal_epidermal_layer0.77818226
146MP0003941_abnormal_skin_development0.77328646
147MP0002160_abnormal_reproductive_system0.75857988
148MP0003436_decreased_susceptibility_to0.75371680
149MP0005508_abnormal_skeleton_morphology0.75123654
150MP0009642_abnormal_blood_homeostasis0.75090220
151MP0005395_other_phenotype0.74591568
152MP0005389_reproductive_system_phenotype0.73915721
153MP0000750_abnormal_muscle_regeneration0.73333681
154MP0005330_cardiomyopathy0.72826022
155MP0003936_abnormal_reproductive_system0.71905634
156MP0000566_synostosis0.71376988
157MP0000003_abnormal_adipose_tissue0.70639756
158MP0001765_abnormal_ion_homeostasis0.67861864
159MP0002080_prenatal_lethality0.67565022
160MP0002111_abnormal_tail_morphology0.67518522
161MP0003075_altered_response_to0.66942759
162MP0004043_abnormal_pH_regulation0.66444184
163MP0000383_abnormal_hair_follicle0.66412653
164MP0000013_abnormal_adipose_tissue0.65478018
165MP0005197_abnormal_uvea_morphology0.64783963
166MP0000681_abnormal_thyroid_gland0.64315425
167MP0001730_embryonic_growth_arrest0.63876671
168MP0008438_abnormal_cutaneous_collagen0.63775656
169MP0002282_abnormal_trachea_morphology0.63412525

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.76120338
2Abnormal respiratory epithelium morphology (HP:0012253)6.85208416
3Abnormal respiratory motile cilium morphology (HP:0005938)6.85208416
4Abnormal respiratory motile cilium physiology (HP:0012261)6.58469458
5Rhinitis (HP:0012384)6.40277228
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.24021733
7Absent/shortened dynein arms (HP:0200106)6.24021733
8Abnormal ciliary motility (HP:0012262)6.23849764
9Abnormality of aromatic amino acid family metabolism (HP:0004338)5.70867340
10Chronic bronchitis (HP:0004469)5.00999144
11Generalized aminoaciduria (HP:0002909)4.51722823
12Aplastic anemia (HP:0001915)4.51261017
13Nasal polyposis (HP:0100582)4.27898990
14Hypothermia (HP:0002045)4.23941341
15Abnormality of cells of the erythroid lineage (HP:0012130)4.19209145
16Abnormality of the heme biosynthetic pathway (HP:0010472)4.12997893
17Bronchiectasis (HP:0002110)4.10347859
18Abnormal number of erythroid precursors (HP:0012131)3.92849119
19Thrombocytosis (HP:0001894)3.76357522
20Abnormal hemoglobin (HP:0011902)3.64412670
21Hepatic necrosis (HP:0002605)3.62589749
22Hypoglycemic coma (HP:0001325)3.57387246
23Abnormality of the nasal mucosa (HP:0000433)3.53500113
24Male infertility (HP:0003251)3.39793012
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.39167956
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34498828
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34498828
28Reticulocytopenia (HP:0001896)3.33098506
29Infertility (HP:0000789)3.10988075
30Hand muscle atrophy (HP:0009130)3.02144378
31Occipital encephalocele (HP:0002085)3.01713684
32Hypobetalipoproteinemia (HP:0003563)2.97788130
33Hepatocellular necrosis (HP:0001404)2.97702153
34Macrocytic anemia (HP:0001972)2.96097578
35Pallor (HP:0000980)2.96008977
36Intrahepatic cholestasis (HP:0001406)2.94968115
37Proximal tubulopathy (HP:0000114)2.90016582
38Reduced antithrombin III activity (HP:0001976)2.87895106
39Distal upper limb amyotrophy (HP:0007149)2.81567148
40Upper limb amyotrophy (HP:0009129)2.81567148
41Type I transferrin isoform profile (HP:0003642)2.79788918
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75778875
43Dicarboxylic aciduria (HP:0003215)2.75778875
44Prolonged partial thromboplastin time (HP:0003645)2.75003480
45Renal cortical cysts (HP:0000803)2.73353441
46Vacuolated lymphocytes (HP:0001922)2.73252363
47Prolonged bleeding time (HP:0003010)2.73080725
48Delayed CNS myelination (HP:0002188)2.69461062
49Glycosuria (HP:0003076)2.67906804
50Abnormality of urine glucose concentration (HP:0011016)2.67906804
51Nuclear cataract (HP:0100018)2.67427263
52Hyperglycinemia (HP:0002154)2.66173815
533-Methylglutaconic aciduria (HP:0003535)2.65619178
54Abnormality of fatty-acid metabolism (HP:0004359)2.65116773
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63907419
56Hyperammonemia (HP:0001987)2.62043390
57Hyperbilirubinemia (HP:0002904)2.61459064
58Testicular atrophy (HP:0000029)2.61185534
59Increased intramyocellular lipid droplets (HP:0012240)2.60175042
60Increased muscle lipid content (HP:0009058)2.57549973
61Progressive muscle weakness (HP:0003323)2.54869625
62Pancytopenia (HP:0001876)2.53790688
63Microretrognathia (HP:0000308)2.52535245
64Renal Fanconi syndrome (HP:0001994)2.52431772
65Rough bone trabeculation (HP:0100670)2.49898841
66Hyperlipoproteinemia (HP:0010980)2.46592021
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46397237
68Atelectasis (HP:0100750)2.45605398
69Abnormality of pyrimidine metabolism (HP:0004353)2.42375319
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41449721
71Congenital primary aphakia (HP:0007707)2.40410256
72Lethargy (HP:0001254)2.40012919
73Microcytic anemia (HP:0001935)2.39272377
74Short nail (HP:0001799)2.38656612
75Xanthomatosis (HP:0000991)2.38524103
76Medial flaring of the eyebrow (HP:0010747)2.34949029
77Nephrogenic diabetes insipidus (HP:0009806)2.34208429
78Epistaxis (HP:0000421)2.32285744
79Abnormality of the distal phalanges of the toes (HP:0010182)2.30775173
80Distal lower limb muscle weakness (HP:0009053)2.25888870
81Lipid accumulation in hepatocytes (HP:0006561)2.25883911
82Hypokinesia (HP:0002375)2.24338088
83Nausea (HP:0002018)2.24024123
84Exertional dyspnea (HP:0002875)2.21164206
85Opisthotonus (HP:0002179)2.20703118
86Glucose intolerance (HP:0000833)2.20124590
87Increased hepatocellular lipid droplets (HP:0006565)2.18973400
88Spontaneous abortion (HP:0005268)2.18496113
89Gait imbalance (HP:0002141)2.18266803
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18120005
91Colon cancer (HP:0003003)2.17387599
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17163023
93Abnormality of the intrinsic pathway (HP:0010989)2.16209580
94Beaking of vertebral bodies (HP:0004568)2.15736528
95Gingival bleeding (HP:0000225)2.13746962
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.13604205
97Poikilocytosis (HP:0004447)2.12242265
98Ragged-red muscle fibers (HP:0003200)2.11322439
99Lactic acidosis (HP:0003128)2.05301605
100Hypoplasia of the uterus (HP:0000013)2.05288007
101Entropion (HP:0000621)2.04312747
102Abnormality of serum amino acid levels (HP:0003112)2.01552137
103Hyperacusis (HP:0010780)2.01276675
104Abnormal protein glycosylation (HP:0012346)2.01177638
105Abnormal glycosylation (HP:0012345)2.01177638
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01177638
107Abnormal protein N-linked glycosylation (HP:0012347)2.01177638
108Ketosis (HP:0001946)2.00740563
109Abnormality of reticulocytes (HP:0004312)1.99675911
110True hermaphroditism (HP:0010459)1.99300470
111Increased serum lactate (HP:0002151)1.98402055
112Petechiae (HP:0000967)1.97205863
113Late onset (HP:0003584)1.96574119
114Recurrent otitis media (HP:0000403)1.95878826
115Purpura (HP:0000979)1.94831511
116Adrenal hypoplasia (HP:0000835)1.92146852
117Mitochondrial inheritance (HP:0001427)1.92122677
118Neonatal hypoglycemia (HP:0001998)1.91773619
119Hyperphosphaturia (HP:0003109)1.91167601
120Hyperglycinuria (HP:0003108)1.90401921
121Stridor (HP:0010307)1.89870029
122Abnormality of serine family amino acid metabolism (HP:0010894)1.89449662
123Abnormality of glycine metabolism (HP:0010895)1.89449662
124Abnormal mitochondria in muscle tissue (HP:0008316)1.87628559
125Postaxial foot polydactyly (HP:0001830)1.86917741
126Abnormality of renal resorption (HP:0011038)1.85792562
127Tinnitus (HP:0000360)1.85757680
128Increased CSF lactate (HP:0002490)1.84928574
129Poikiloderma (HP:0001029)1.84153230
130Acanthocytosis (HP:0001927)1.84009513
131Brushfield spots (HP:0001088)1.83109082
132Cystic liver disease (HP:0006706)1.82646472
133Cerebral edema (HP:0002181)1.82517724
134Renal salt wasting (HP:0000127)1.82472563
135Vomiting (HP:0002013)1.82071290
136Impaired platelet aggregation (HP:0003540)1.82040890
137Abnormal platelet function (HP:0011869)1.82040890
138Growth hormone excess (HP:0000845)1.80962583
139Molar tooth sign on MRI (HP:0002419)1.80311579
140Abnormality of midbrain morphology (HP:0002418)1.80311579
141Amaurosis fugax (HP:0100576)1.79706219
142Premature graying of hair (HP:0002216)1.79379650
143Prolonged neonatal jaundice (HP:0006579)1.79268663
144Pancreatic fibrosis (HP:0100732)1.78308343
145Bronchitis (HP:0012387)1.78242452
146Neutropenia (HP:0001875)1.77968947
147Acute encephalopathy (HP:0006846)1.77950489
148Abnormality of the common coagulation pathway (HP:0010990)1.77597161
149Abnormality of the umbilical cord (HP:0010881)1.76130284
150Recurrent sinusitis (HP:0011108)1.73414161
151Gout (HP:0001997)1.72668097
152Abnormal hair laboratory examination (HP:0003328)1.72664951
153Poor coordination (HP:0002370)1.69369218
154Abnormality of the fetal cardiovascular system (HP:0010948)1.68101525
155Abnormal umbilical cord blood vessels (HP:0011403)1.68101525
156Single umbilical artery (HP:0001195)1.68101525
157Facial cleft (HP:0002006)1.66674402
158Vertebral compression fractures (HP:0002953)1.66501365
159Oculomotor apraxia (HP:0000657)1.63828357
160Premature rupture of membranes (HP:0001788)1.63490922
161Diaphragmatic weakness (HP:0009113)1.62946771
162Abnormal trabecular bone morphology (HP:0100671)1.62674854
163Bell-shaped thorax (HP:0001591)1.60933459
164Cervical subluxation (HP:0003308)1.60737480
165Abnormalities of placenta or umbilical cord (HP:0001194)1.59091010
166Median cleft lip (HP:0000161)1.58596822
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58430462
168Chronic sinusitis (HP:0011109)1.57798605
169Acute necrotizing encephalopathy (HP:0006965)1.57773657
170Abnormality of the anterior horn cell (HP:0006802)1.57412523
171Degeneration of anterior horn cells (HP:0002398)1.57412523
172Progressive neurologic deterioration (HP:0002344)1.56985602
173Abnormality of mucopolysaccharide metabolism (HP:0011020)1.55441884
174Abnormality of polysaccharide metabolism (HP:0011012)1.55441884
175Abnormality of glycosaminoglycan metabolism (HP:0004371)1.55441884
176Overriding aorta (HP:0002623)1.55340063
177Aplasia/Hypoplasia of the tongue (HP:0010295)1.55022281
178Vascular calcification (HP:0004934)1.54446031
179Abnormality of liposaccharide metabolism (HP:0010968)1.54082288
180Abnormality of glycosphingolipid metabolism (HP:0004343)1.54082288
181Abnormality of glycolipid metabolism (HP:0010969)1.54082288
182Elfin facies (HP:0004428)1.52983082
183Down-sloping shoulders (HP:0200021)1.52771358
184Insomnia (HP:0100785)1.52333304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.28441550
2MST1R3.82018493
3FLT33.51793544
4BCKDK3.27559226
5VRK23.23693062
6MST43.20680440
7TESK13.05807812
8TGFBR12.85665406
9RPS6KB22.81195567
10PBK2.73822533
11WEE12.60664994
12DYRK32.46185121
13BRSK22.44697735
14STK162.42452980
15ARAF2.28990002
16TESK22.28693541
17SMG12.27882932
18MAP3K122.23924859
19MAP2K32.14206602
20NME12.12008733
21TNIK2.05288867
22MAP3K62.02822034
23LIMK11.91965486
24PASK1.91781359
25MET1.88781743
26BUB11.87487602
27IRAK31.87238143
28VRK11.84261879
29EPHA21.83750324
30ZAP701.83554549
31TLK11.64888401
32MAP2K61.60825358
33PIM21.59418894
34ADRBK21.55888376
35KIT1.55170152
36NLK1.52356696
37ABL21.42383810
38FRK1.41746846
39MAP2K21.40875922
40MAPKAPK31.40494112
41PDK21.34896597
42MATK1.33357716
43PIK3CG1.32352931
44TEC1.31717385
45EEF2K1.29355041
46MAPKAPK51.25862776
47MAP4K11.24426471
48ACVR1B1.23918853
49EIF2AK11.21012574
50MAP3K111.18630666
51MAP3K141.18627712
52BTK1.15191281
53PTK21.14167585
54JAK31.11201601
55MAPK151.08543737
56ERN11.05174202
57IKBKB1.04369851
58TTK1.02889079
59WNK40.99234439
60CDK70.97870052
61TRIM280.97057115
62EIF2AK30.96424446
63ZAK0.96005756
64ICK0.94887896
65ERBB40.93729470
66MYLK0.93628086
67TRIB30.92263262
68SCYL20.91831143
69SIK10.89878023
70AKT20.87839505
71MAP4K20.87098153
72CAMK2G0.86978544
73AURKB0.86409594
74PRKD30.84294594
75STK390.83201639
76RPS6KA50.82277938
77MKNK10.81990990
78PIM10.81506778
79MAP3K30.80930017
80PKN20.79999464
81TGFBR20.79815409
82RPS6KL10.78768430
83RPS6KC10.78768430
84BRSK10.77538682
85RPS6KA60.77320430
86TYK20.77267632
87DAPK10.75112900
88CDK80.74183495
89BMPR1B0.74105648
90TIE10.73967016
91EPHB10.73520497
92PLK10.72708421
93FER0.71090585
94TAOK30.69996293
95PAK40.69093924
96TAF10.68858533
97BCR0.68241401
98PRKG20.68074600
99TAOK20.67840983
100INSRR0.67505722
101MAPK110.67032162
102PRKCI0.66764203
103CAMKK20.66424052
104FGFR40.64868543
105CSF1R0.64181457
106SRPK10.61832294
107TBK10.61233389
108BRAF0.60931425
109CHUK0.60710727
110CDK190.59717346
111STK100.59267369
112IKBKE0.58744975
113CSNK2A10.57146265
114MUSK0.57047518
115NEK20.55725762
116BMX0.55034434
117PRKD20.54589478
118GRK60.54437411
119SYK0.53327643
120RPS6KA20.53251370
121ADRBK10.52032513
122CAMK2D0.51395816
123CSNK2A20.50985005
124HIPK20.50584233
125RPS6KA40.50521840
126MAP3K80.49888342
127ATR0.49829809
128TSSK60.49349658
129MAPK40.46220718
130STK40.45069969
131AURKA0.44837004
132ILK0.44122723
133CSNK1G30.43996829
134IRAK40.42779156
135PAK10.41305378
136MAPK30.41297932
137BLK0.39447361
138NEK10.39253014
139CSNK1A1L0.39168114
140LCK0.39058791
141LMTK20.38374494
142PINK10.37379896
143PTK60.37192889
144RAF10.37171304
145MAP2K10.36961176
146LRRK20.36512415
147CDK90.36418880
148CSNK1G10.36045269
149KDR0.35985325
150DYRK1B0.34660148
151NEK90.34376812
152CHEK20.31759010
153MTOR0.30787545
154LATS20.29658432
155DAPK30.29446991
156EPHB20.27458226
157TAOK10.21462458
158MAP3K20.20987654
159PTK2B0.20110758
160STK30.18861410

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.27686301
2Folate biosynthesis_Homo sapiens_hsa007903.13762304
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62571423
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.56141181
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34052810
6Protein export_Homo sapiens_hsa030602.29444048
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.16188525
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15300312
9Drug metabolism - other enzymes_Homo sapiens_hsa009831.90755835
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.89565890
11RNA polymerase_Homo sapiens_hsa030201.86944200
12DNA replication_Homo sapiens_hsa030301.82021058
13Proteasome_Homo sapiens_hsa030501.81599981
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.75634597
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72628785
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66461051
17Homologous recombination_Homo sapiens_hsa034401.62423752
18Pyrimidine metabolism_Homo sapiens_hsa002401.62387355
19Vibrio cholerae infection_Homo sapiens_hsa051101.61153106
20Mismatch repair_Homo sapiens_hsa034301.60312203
21Peroxisome_Homo sapiens_hsa041461.56823583
22Vitamin B6 metabolism_Homo sapiens_hsa007501.56400003
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54690654
24Fatty acid degradation_Homo sapiens_hsa000711.53129804
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48565529
26Tryptophan metabolism_Homo sapiens_hsa003801.46258758
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45446166
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45398369
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43928043
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42785260
31Chemical carcinogenesis_Homo sapiens_hsa052041.40479436
32Histidine metabolism_Homo sapiens_hsa003401.39523224
33Sulfur relay system_Homo sapiens_hsa041221.38224629
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38191280
35Selenocompound metabolism_Homo sapiens_hsa004501.37584122
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33813998
37ABC transporters_Homo sapiens_hsa020101.27337281
38Base excision repair_Homo sapiens_hsa034101.21770378
39One carbon pool by folate_Homo sapiens_hsa006701.20879043
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.18271216
41Nucleotide excision repair_Homo sapiens_hsa034201.17649220
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15255098
43Glutathione metabolism_Homo sapiens_hsa004801.14056351
44Alzheimers disease_Homo sapiens_hsa050101.12005277
45Tyrosine metabolism_Homo sapiens_hsa003501.09360035
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08250786
47Spliceosome_Homo sapiens_hsa030401.06012604
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.03539174
49Fatty acid elongation_Homo sapiens_hsa000621.03024758
50Lysosome_Homo sapiens_hsa041421.02208531
51Arginine biosynthesis_Homo sapiens_hsa002201.01668481
52Phenylalanine metabolism_Homo sapiens_hsa003600.99248974
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99166178
54Galactose metabolism_Homo sapiens_hsa000520.97570640
55Sphingolipid metabolism_Homo sapiens_hsa006000.96081734
56Complement and coagulation cascades_Homo sapiens_hsa046100.95818519
57Pentose phosphate pathway_Homo sapiens_hsa000300.95246279
58beta-Alanine metabolism_Homo sapiens_hsa004100.95218394
59Caffeine metabolism_Homo sapiens_hsa002320.93891735
60Basal transcription factors_Homo sapiens_hsa030220.93665516
61Collecting duct acid secretion_Homo sapiens_hsa049660.93394911
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92422782
63Propanoate metabolism_Homo sapiens_hsa006400.92402775
64RNA degradation_Homo sapiens_hsa030180.91016212
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.90710037
66Biosynthesis of amino acids_Homo sapiens_hsa012300.89655901
67Thyroid cancer_Homo sapiens_hsa052160.89021910
68Pyruvate metabolism_Homo sapiens_hsa006200.87717359
69Butanoate metabolism_Homo sapiens_hsa006500.87014386
70Other glycan degradation_Homo sapiens_hsa005110.84348019
71Retinol metabolism_Homo sapiens_hsa008300.83471399
72Fructose and mannose metabolism_Homo sapiens_hsa000510.81964169
73RNA transport_Homo sapiens_hsa030130.81840453
74Steroid biosynthesis_Homo sapiens_hsa001000.78905792
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77395291
76Metabolic pathways_Homo sapiens_hsa011000.77210764
77Vitamin digestion and absorption_Homo sapiens_hsa049770.75940100
78Fatty acid metabolism_Homo sapiens_hsa012120.75653309
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72304257
80Cell cycle_Homo sapiens_hsa041100.72039679
81Starch and sucrose metabolism_Homo sapiens_hsa005000.70847201
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70788779
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70379076
84Sulfur metabolism_Homo sapiens_hsa009200.68313179
85Carbon metabolism_Homo sapiens_hsa012000.68265684
86p53 signaling pathway_Homo sapiens_hsa041150.68056940
87Purine metabolism_Homo sapiens_hsa002300.65026440
88Parkinsons disease_Homo sapiens_hsa050120.62766722
89Arachidonic acid metabolism_Homo sapiens_hsa005900.60124254
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58917148
91Systemic lupus erythematosus_Homo sapiens_hsa053220.57611165
92Fanconi anemia pathway_Homo sapiens_hsa034600.57466162
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57186550
94Regulation of autophagy_Homo sapiens_hsa041400.54529055
95PPAR signaling pathway_Homo sapiens_hsa033200.54217586
96Tight junction_Homo sapiens_hsa045300.53064436
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52038706
98Arginine and proline metabolism_Homo sapiens_hsa003300.51847364
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49794960
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49364588
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49178458
102Shigellosis_Homo sapiens_hsa051310.48352637
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48036520
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47426779
105Non-homologous end-joining_Homo sapiens_hsa034500.47274989
106Herpes simplex infection_Homo sapiens_hsa051680.47116677
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44342447
108Oxidative phosphorylation_Homo sapiens_hsa001900.43965360
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43589494
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42492705
111Mineral absorption_Homo sapiens_hsa049780.40718629
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40348360
113Fat digestion and absorption_Homo sapiens_hsa049750.37068283
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.35869916
115Glycerolipid metabolism_Homo sapiens_hsa005610.35426269
116Huntingtons disease_Homo sapiens_hsa050160.35348584
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34311629
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32189090
119N-Glycan biosynthesis_Homo sapiens_hsa005100.31702083
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.31019533
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30718403
122Hippo signaling pathway_Homo sapiens_hsa043900.28144164

Most similar genes based on co-expression Upload to Enrichr

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