WBP1LP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.13671970
2regulation of mitotic spindle organization (GO:0060236)4.83936845
3response to redox state (GO:0051775)4.67412027
4positive regulation of actin filament depolymerization (GO:0030836)4.16853435
5regulation of early endosome to late endosome transport (GO:2000641)4.10454197
6regulation of spindle organization (GO:0090224)3.86235289
7mitochondrial calcium ion transport (GO:0006851)3.77679096
8kinetochore organization (GO:0051383)3.71002905
9barbed-end actin filament capping (GO:0051016)3.54017393
10mitotic chromosome condensation (GO:0007076)3.46141528
11kinetochore assembly (GO:0051382)3.33240732
12negative regulation of focal adhesion assembly (GO:0051895)3.32994889
13negative regulation of cell junction assembly (GO:1901889)3.32994889
14negative regulation of adherens junction organization (GO:1903392)3.32994889
15cellular response to thyroid hormone stimulus (GO:0097067)3.30458058
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29975611
17mitotic nuclear envelope reassembly (GO:0007084)3.24509418
18nuclear envelope reassembly (GO:0031468)3.24509418
19protoporphyrinogen IX metabolic process (GO:0046501)3.24245197
20regulation of chromatin binding (GO:0035561)3.19466790
21negative regulation of erythrocyte differentiation (GO:0045647)3.16158720
22ruffle organization (GO:0031529)3.14212914
23response to thyroid hormone (GO:0097066)3.09486083
24chromosome condensation (GO:0030261)3.09449072
25regulation of exit from mitosis (GO:0007096)3.07131085
26muscle atrophy (GO:0014889)3.05637295
27extracellular fibril organization (GO:0043206)3.03020592
28regulation of translational termination (GO:0006449)3.02379921
29negative regulation of homotypic cell-cell adhesion (GO:0034111)3.00622977
30cellular response to arsenic-containing substance (GO:0071243)2.94866024
31neutrophil activation involved in immune response (GO:0002283)2.94454601
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93068603
33platelet degranulation (GO:0002576)2.91704413
34regulation of metalloenzyme activity (GO:0048552)2.90272921
35oligosaccharide catabolic process (GO:0009313)2.89692612
36mitotic sister chromatid segregation (GO:0000070)2.89368726
37pentose metabolic process (GO:0019321)2.87976137
38positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.87547721
39platelet aggregation (GO:0070527)2.86413056
40membrane invagination (GO:0010324)2.86229865
41establishment of mitotic spindle localization (GO:0040001)2.86105073
42ncRNA 3-end processing (GO:0043628)2.81468190
43positive regulation of catenin import into nucleus (GO:0035413)2.80005670
44positive regulation of endothelial cell differentiation (GO:0045603)2.79954835
45polyamine biosynthetic process (GO:0006596)2.79620796
46phagocytosis, engulfment (GO:0006911)2.79231018
47establishment of mitotic spindle orientation (GO:0000132)2.78668241
48regulation of integrin activation (GO:0033623)2.77944265
49hyaluronan catabolic process (GO:0030214)2.77014453
50mitochondrial calcium ion homeostasis (GO:0051560)2.74352521
51regulation of oxidative phosphorylation (GO:0002082)2.74002920
52positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.70967434
53glycosphingolipid catabolic process (GO:0046479)2.68603022
54endothelial cell proliferation (GO:0001935)2.67716342
55beta-amyloid metabolic process (GO:0050435)2.65569587
56negative regulation of stress fiber assembly (GO:0051497)2.65341751
57protein neddylation (GO:0045116)2.63704113
58fusion of sperm to egg plasma membrane (GO:0007342)2.62870257
59virion assembly (GO:0019068)2.61617444
60negative regulation of platelet activation (GO:0010544)2.61498473
61regulation of endothelial cell chemotaxis (GO:2001026)2.60393012
62L-phenylalanine metabolic process (GO:0006558)2.59862320
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.59862320
64positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58350036
65fibril organization (GO:0097435)2.57280409
66regulation of platelet activation (GO:0010543)2.55481818
67pentose-phosphate shunt (GO:0006098)2.55063805
68negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.55014180
69rRNA methylation (GO:0031167)2.54420565
70DNA packaging (GO:0006323)2.53913820
71protein localization to chromosome, centromeric region (GO:0071459)2.52940771
72sphingosine metabolic process (GO:0006670)2.52644956
73peptidyl-glutamic acid carboxylation (GO:0017187)2.52492476
74protein carboxylation (GO:0018214)2.52492476
75regulation of platelet aggregation (GO:0090330)2.52268084
76adenosine receptor signaling pathway (GO:0001973)2.52186166
77establishment of chromosome localization (GO:0051303)2.51962725
78regulation of mononuclear cell migration (GO:0071675)2.51574809
79mitotic metaphase plate congression (GO:0007080)2.51159821
80COPI coating of Golgi vesicle (GO:0048205)2.49422152
81Golgi transport vesicle coating (GO:0048200)2.49422152
82ribosomal small subunit biogenesis (GO:0042274)2.49023725
83negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.48724155
84sister chromatid segregation (GO:0000819)2.48505138
85regulation of vitamin D biosynthetic process (GO:0060556)2.48234809
86angiogenesis involved in wound healing (GO:0060055)2.48065217
87regulation of integrin-mediated signaling pathway (GO:2001044)2.47747428
88lipoxygenase pathway (GO:0019372)2.47721939
89natural killer cell mediated cytotoxicity (GO:0042267)2.47633480
90natural killer cell mediated immunity (GO:0002228)2.47633480
91regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.46648290
92cell-substrate junction assembly (GO:0007044)2.46045605
93negative regulation of axon extension involved in axon guidance (GO:0048843)2.43831507
94viral protein processing (GO:0019082)2.43601795
95ceramide catabolic process (GO:0046514)2.40824320
96cortical actin cytoskeleton organization (GO:0030866)2.40411256
97regulation of mitochondrial membrane potential (GO:0051881)2.40107854
98pyrimidine nucleoside salvage (GO:0043097)2.39556423
99pyrimidine-containing compound salvage (GO:0008655)2.39556423
100synaptonemal complex assembly (GO:0007130)2.38984389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.63005391
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.73505686
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.90605438
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85485994
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76910745
6SRY_22984422_ChIP-ChIP_TESTIS_Rat2.66202871
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63518417
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52072386
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.40069348
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37285633
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21621478
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.14590476
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09735520
14VDR_21846776_ChIP-Seq_THP-1_Human2.00866125
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86310013
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.86131608
17LXR_22292898_ChIP-Seq_THP-1_Human1.71807567
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69722819
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66462123
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62991736
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61913486
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61599238
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60085593
24NCOR1_26117541_ChIP-Seq_K562_Human1.58595286
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54699249
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51226529
27RACK7_27058665_Chip-Seq_MCF-7_Human1.50645735
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.47951889
29HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47586423
30ZNF263_19887448_ChIP-Seq_K562_Human1.45662353
31ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.43253358
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42756494
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41270005
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39949286
35ATF3_27146783_Chip-Seq_COLON_Human1.39738294
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38319257
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37634069
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37309765
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35871233
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35626410
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35217665
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30386530
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29628629
44VDR_24763502_ChIP-Seq_THP-1_Human1.29057298
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28248166
46TFEB_21752829_ChIP-Seq_HELA_Human1.27731993
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.26908462
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26228954
49GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26072593
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26036872
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25643387
52GATA1_19941826_ChIP-Seq_K562_Human1.24856081
53SPI1_23127762_ChIP-Seq_K562_Human1.24852008
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24594215
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.23148096
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23050995
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22061902
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.21624607
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.21046730
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.20402958
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19200300
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17128605
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.16095599
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15939264
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15659989
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15196964
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15156126
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14861942
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14724578
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.14390121
71MYC_22102868_ChIP-Seq_BL_Human1.13656709
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12865682
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11447824
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11135241
75XRN2_22483619_ChIP-Seq_HELA_Human1.10300690
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.09867563
77DCP1A_22483619_ChIP-Seq_HELA_Human1.09488495
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08898380
79BCOR_27268052_Chip-Seq_Bcells_Human1.08500700
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07396020
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07173838
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06134978
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04665338
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04028042
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03434199
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02427120
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02069744
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.01940992
89MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01754112
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01149988
91KDM2B_26808549_Chip-Seq_DND41_Human1.00564488
92BCL6_27268052_Chip-Seq_Bcells_Human1.00512205
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00201333
94TP53_22127205_ChIP-Seq_IMR90_Human1.00022533
95MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99477659
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99421146
97UBF1/2_26484160_Chip-Seq_HMECs_Human0.99076030
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98867897
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98302991
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98201191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.12640036
2MP0003705_abnormal_hypodermis_morpholog3.51860726
3MP0003656_abnormal_erythrocyte_physiolo3.49010737
4MP0009840_abnormal_foam_cell2.71998059
5MP0003186_abnormal_redox_activity2.69917634
6MP0003303_peritoneal_inflammation2.62474744
7MP0005083_abnormal_biliary_tract2.62037267
8MP0003566_abnormal_cell_adhesion2.54829637
9MP0005058_abnormal_lysosome_morphology2.51077508
10MP0004272_abnormal_basement_membrane2.44039784
11MP0000343_altered_response_to2.38289714
12MP0008260_abnormal_autophagy2.31975865
13MP0008438_abnormal_cutaneous_collagen2.28677853
14MP0005165_increased_susceptibility_to2.27950685
15MP0003111_abnormal_nucleus_morphology2.24888695
16MP0002877_abnormal_melanocyte_morpholog2.24649828
17MP0005410_abnormal_fertilization1.94527755
18MP0003453_abnormal_keratinocyte_physiol1.88844060
19MP0001849_ear_inflammation1.87027243
20MP0005451_abnormal_body_composition1.82813983
21MP0000858_altered_metastatic_potential1.78769291
22MP0003950_abnormal_plasma_membrane1.75612997
23MP0001879_abnormal_lymphatic_vessel1.70507116
24MP0004947_skin_inflammation1.66220415
25MP0009053_abnormal_anal_canal1.66218708
26MP0003011_delayed_dark_adaptation1.65226599
27MP0003091_abnormal_cell_migration1.64017745
28MP0005023_abnormal_wound_healing1.62353793
29MP0002332_abnormal_exercise_endurance1.61885613
30MP0005501_abnormal_skin_physiology1.47295514
31MP0004510_myositis1.46634210
32MP0003279_aneurysm1.44805468
33MP0003075_altered_response_to1.44744707
34MP0003436_decreased_susceptibility_to1.42787622
35MP0008004_abnormal_stomach_pH1.41507888
36MP0000767_abnormal_smooth_muscle1.39567479
37MP0002148_abnormal_hypersensitivity_rea1.30341234
38MP0001853_heart_inflammation1.27754352
39MP0005084_abnormal_gallbladder_morpholo1.21256034
40MP0001533_abnormal_skeleton_physiology1.20956351
41MP0002139_abnormal_hepatobiliary_system1.20577660
42MP0005623_abnormal_meninges_morphology1.19721616
43MP0002295_abnormal_pulmonary_circulatio1.19330762
44MP0003077_abnormal_cell_cycle1.16500449
45MP0000537_abnormal_urethra_morphology1.14707802
46MP0005167_abnormal_blood-brain_barrier1.13671051
47MP0006036_abnormal_mitochondrial_physio1.10654332
48MP0000358_abnormal_cell_content/1.08427429
49MP0003329_amyloid_beta_deposits1.05756795
50MP0008058_abnormal_DNA_repair1.01952663
51MP0001958_emphysema1.01284951
52MP0000465_gastrointestinal_hemorrhage1.00959712
53MP0008932_abnormal_embryonic_tissue1.00413834
54MP0005164_abnormal_response_to1.00188315
55MP0005275_abnormal_skin_tensile0.99457470
56MP0000313_abnormal_cell_death0.99321542
57MP0010368_abnormal_lymphatic_system0.98184336
58MP0004185_abnormal_adipocyte_glucose0.97744947
59MP0005397_hematopoietic_system_phenotyp0.96768941
60MP0001545_abnormal_hematopoietic_system0.96768941
61MP0008775_abnormal_heart_ventricle0.95810638
62MP0009764_decreased_sensitivity_to0.95713213
63MP0005257_abnormal_intraocular_pressure0.95377068
64MP0003806_abnormal_nucleotide_metabolis0.94614210
65MP0003718_maternal_effect0.94302649
66MP0000604_amyloidosis0.91826981
67MP0005621_abnormal_cell_physiology0.91048337
68MP0000249_abnormal_blood_vessel0.89690922
69MP0000013_abnormal_adipose_tissue0.89575080
70MP0002998_abnormal_bone_remodeling0.89132467
71MP0001835_abnormal_antigen_presentation0.87665487
72MP0003724_increased_susceptibility_to0.85476879
73MP0009697_abnormal_copulation0.83488076
74MP0005384_cellular_phenotype0.82886627
75MP0003448_altered_tumor_morphology0.82229897
76MP0001542_abnormal_bone_strength0.81714968
77MP0002132_abnormal_respiratory_system0.81618181
78MP0005000_abnormal_immune_tolerance0.79337066
79MP0002419_abnormal_innate_immunity0.79233497
80MP0009333_abnormal_splenocyte_physiolog0.78522033
81MP0000747_muscle_weakness0.77924033
82MP0003172_abnormal_lysosome_physiology0.77875241
83MP0001216_abnormal_epidermal_layer0.76058636
84MP0009384_cardiac_valve_regurgitation0.75639473
85MP0004957_abnormal_blastocyst_morpholog0.75238240
86MP0002653_abnormal_ependyma_morphology0.74745074
87MP0000534_abnormal_ureter_morphology0.74731713
88MP0002972_abnormal_cardiac_muscle0.73923926
89MP0003300_gastrointestinal_ulcer0.73706185
90MP0008469_abnormal_protein_level0.72748277
91MP0000003_abnormal_adipose_tissue0.72212016
92MP0010155_abnormal_intestine_physiology0.71556218
93MP0008874_decreased_physiological_sensi0.70993892
94MP0005330_cardiomyopathy0.70739723
95MP0005595_abnormal_vascular_smooth0.68381189
96MP0005584_abnormal_enzyme/coenzyme_acti0.67066406
97MP0002127_abnormal_cardiovascular_syste0.64760213
98MP0003795_abnormal_bone_structure0.64646356
99MP0001697_abnormal_embryo_size0.64629208
100MP0002128_abnormal_blood_circulation0.64053557

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)4.95041153
2Aplasia/Hypoplasia of the sacrum (HP:0008517)4.70430023
3Menorrhagia (HP:0000132)4.35372997
4Prolonged bleeding time (HP:0003010)4.15924519
5Increased mean platelet volume (HP:0011877)3.97070087
6Purpura (HP:0000979)3.92082288
7Short nail (HP:0001799)3.80799662
8Abnormal platelet volume (HP:0011876)3.68994922
9Long clavicles (HP:0000890)3.56076655
10Peritonitis (HP:0002586)3.40980525
11Papilledema (HP:0001085)3.31316685
12Premature rupture of membranes (HP:0001788)3.12700619
13Abnormality of glycolipid metabolism (HP:0010969)3.11624183
14Abnormality of liposaccharide metabolism (HP:0010968)3.11624183
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.11624183
16Paralysis (HP:0003470)2.96366566
17Elevated erythrocyte sedimentation rate (HP:0003565)2.94742452
18Insomnia (HP:0100785)2.90267813
193-Methylglutaconic aciduria (HP:0003535)2.83518998
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.82456842
21Epistaxis (HP:0000421)2.78612493
22Nuclear cataract (HP:0100018)2.76614915
23Hypoplastic pelvis (HP:0008839)2.74622616
24Birth length less than 3rd percentile (HP:0003561)2.73949010
25Ragged-red muscle fibers (HP:0003200)2.70398732
26Testicular atrophy (HP:0000029)2.63687835
27Breast hypoplasia (HP:0003187)2.62104413
28Abnormality of the heme biosynthetic pathway (HP:0010472)2.60540030
29Turricephaly (HP:0000262)2.56017001
30Entropion (HP:0000621)2.55610999
31Increased serum pyruvate (HP:0003542)2.50173990
32Vertebral compression fractures (HP:0002953)2.47365052
33Fragile skin (HP:0001030)2.46572189
34Abnormality of glycolysis (HP:0004366)2.46113493
35Slender long bone (HP:0003100)2.45704450
36Delayed closure of the anterior fontanelle (HP:0001476)2.43758524
37Hypergonadotropic hypogonadism (HP:0000815)2.41954430
38Hyperthyroidism (HP:0000836)2.41338328
39Hepatosplenomegaly (HP:0001433)2.41178697
40Long palpebral fissure (HP:0000637)2.40676696
41Abnormality of magnesium homeostasis (HP:0004921)2.37415478
42Upper limb muscle weakness (HP:0003484)2.35323036
43Impaired platelet aggregation (HP:0003540)2.33550307
44Abnormal platelet function (HP:0011869)2.33550307
45Hyperlipoproteinemia (HP:0010980)2.33426497
46Orthostatic hypotension (HP:0001278)2.30090438
47Nausea (HP:0002018)2.26867533
48Increased serum ferritin (HP:0003281)2.25650488
49Symptomatic seizures (HP:0011145)2.23573502
50Tetany (HP:0001281)2.22411471
51Blue sclerae (HP:0000592)2.17887184
52Hypokinesia (HP:0002375)2.17290353
53Polycythemia (HP:0001901)2.16801875
54Abnormality of the tricuspid valve (HP:0001702)2.16260633
55Onycholysis (HP:0001806)2.14675589
56Xanthomatosis (HP:0000991)2.14005219
57Myocardial infarction (HP:0001658)2.11522438
58Hypoparathyroidism (HP:0000829)2.09449045
59Renal Fanconi syndrome (HP:0001994)2.09403804
60Patchy hypopigmentation of hair (HP:0011365)2.09140372
61Protrusio acetabuli (HP:0003179)2.05408104
62Abnormality of the distal phalanges of the toes (HP:0010182)2.03473895
63Ileus (HP:0002595)2.02428200
64Cholecystitis (HP:0001082)2.01103064
65Abnormal gallbladder physiology (HP:0012438)2.01103064
66Reduced subcutaneous adipose tissue (HP:0003758)2.00977256
67Generalized aminoaciduria (HP:0002909)2.00202086
68Hyperacusis (HP:0010780)1.99970723
69Hypertensive crisis (HP:0100735)1.99857740
70Flat cornea (HP:0007720)1.98997805
71Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97525366
72Mitral stenosis (HP:0001718)1.97394039
73Short femoral neck (HP:0100864)1.96087326
74Osteolytic defects of the hand bones (HP:0009699)1.95520144
75Osteolytic defects of the phalanges of the hand (HP:0009771)1.95520144
76Decreased skull ossification (HP:0004331)1.93464392
77Hepatocellular carcinoma (HP:0001402)1.90582133
78Delayed cranial suture closure (HP:0000270)1.87140156
79Abnormality of skull ossification (HP:0002703)1.86108289
80Gingival bleeding (HP:0000225)1.85984489
81Abnormal spermatogenesis (HP:0008669)1.85485980
82Abnormality of the Achilles tendon (HP:0005109)1.84788205
83Stroke (HP:0001297)1.84197672
84Cardiomegaly (HP:0001640)1.83911115
85Ventricular tachycardia (HP:0004756)1.83574031
86Natal tooth (HP:0000695)1.82547152
87Prolonged neonatal jaundice (HP:0006579)1.80425358
88Mesangial abnormality (HP:0001966)1.80202482
89Glomerulosclerosis (HP:0000096)1.77509825
90Spontaneous hematomas (HP:0007420)1.77127116
91Generalized amyotrophy (HP:0003700)1.75071023
92Abnormality of lateral ventricle (HP:0030047)1.74648008
93Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.74336106
94Death in childhood (HP:0003819)1.74325322
95Reticulocytosis (HP:0001923)1.73242983
96Atrophic scars (HP:0001075)1.73099586
97Dysautonomia (HP:0002459)1.71157733
98Pili torti (HP:0003777)1.70984061
99Progressive muscle weakness (HP:0003323)1.69776972
100Hypomagnesemia (HP:0002917)1.68785577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA4.15513716
2NME23.93811072
3BUB13.81054915
4NEK13.24372423
5EPHB23.23558554
6EIF2AK13.08162282
7MAPKAPK32.77147608
8STK162.62683391
9IRAK32.44205497
10BRSK12.44022873
11NEK22.17749982
12PBK2.09327752
13MAP4K21.97980605
14TESK11.79986720
15SIK11.75577101
16BCKDK1.75263319
17AURKA1.65775872
18ARAF1.61987474
19TAOK21.61870036
20ABL21.60246506
21TAOK11.54986962
22CDC42BPA1.51071307
23MET1.39115011
24VRK21.34244092
25DAPK31.31065096
26MAPK111.24845384
27MOS1.20889346
28PIM21.18973529
29BRAF1.18819248
30STK101.15496831
31DDR21.13043842
32BMX1.12782733
33STK31.12239948
34MYLK1.04510883
35MELK1.03129241
36PTK20.99737525
37TTN0.97537577
38MST1R0.94608491
39ILK0.92936487
40MAP3K130.92564412
41ERN10.91008075
42CCNB10.88577889
43PAK10.87988904
44MAP3K80.87021682
45STK40.83642561
46LIMK10.83056316
47TRIB30.82111967
48TGFBR20.82106938
49MAPKAPK20.79766761
50PDGFRA0.78510248
51CLK10.77227015
52RIPK40.77222316
53TESK20.76082659
54MST40.73818357
55IRAK20.71712133
56SMG10.70208920
57AURKB0.67387661
58PAK40.66931645
59PAK20.66851221
60MAP2K30.65575650
61ZAP700.64226431
62GRK50.60727863
63RPS6KB20.60205890
64PRPF4B0.59851595
65EEF2K0.59462944
66MAP3K30.59258373
67CSK0.58079143
68PLK10.57936865
69TIE10.57608494
70KSR20.57153502
71ERBB40.52605390
72CSF1R0.51411818
73MAP3K110.50767946
74EPHA20.48781512
75CAMK2D0.48655817
76PTK2B0.46483795
77MATK0.45848255
78MAP3K60.45157853
79LMTK20.43227468
80HIPK20.43207979
81TYRO30.43088387
82IKBKB0.42611978
83CAMK2G0.41525967
84GRK70.41209365
85BLK0.41182616
86TGFBR10.40201964
87TTK0.39642709
88PDPK10.39010674
89LATS20.39008397
90TRPM70.37317459
91TBK10.35439834
92MARK20.34998340
93MARK30.34692842
94ICK0.33971844
95STK380.33873814
96CDK140.32355992
97MAP2K20.30959487
98MAP2K10.30600491
99SIK30.29511171
100KDR0.27815667

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.25891331
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07788232
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.04212998
4Other glycan degradation_Homo sapiens_hsa005112.76135574
5Shigellosis_Homo sapiens_hsa051312.24928452
6ECM-receptor interaction_Homo sapiens_hsa045122.20483114
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.13303379
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.09474317
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.07452536
10Fatty acid elongation_Homo sapiens_hsa000622.03993546
11Ribosome_Homo sapiens_hsa030102.03596411
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.94252706
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91897562
14Platelet activation_Homo sapiens_hsa046111.72355141
15Glutathione metabolism_Homo sapiens_hsa004801.53725360
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.49480599
17Pentose phosphate pathway_Homo sapiens_hsa000301.46383964
18Apoptosis_Homo sapiens_hsa042101.46260076
19Hematopoietic cell lineage_Homo sapiens_hsa046401.38054313
20VEGF signaling pathway_Homo sapiens_hsa043701.37473484
21Notch signaling pathway_Homo sapiens_hsa043301.35908098
22Vibrio cholerae infection_Homo sapiens_hsa051101.35822295
23Malaria_Homo sapiens_hsa051441.29366161
24Focal adhesion_Homo sapiens_hsa045101.22144066
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21968305
26Bladder cancer_Homo sapiens_hsa052191.21607605
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21332193
28Prion diseases_Homo sapiens_hsa050201.20533247
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19492482
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14708062
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13558773
32Phagosome_Homo sapiens_hsa041451.07551142
33Cell cycle_Homo sapiens_hsa041101.07196341
34MicroRNAs in cancer_Homo sapiens_hsa052061.07055091
35Lysosome_Homo sapiens_hsa041421.06533139
36Galactose metabolism_Homo sapiens_hsa000521.04647063
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04104550
38Renal cell carcinoma_Homo sapiens_hsa052111.03926947
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03216687
40Small cell lung cancer_Homo sapiens_hsa052221.01554789
41Sphingolipid metabolism_Homo sapiens_hsa006000.98901718
42Proteoglycans in cancer_Homo sapiens_hsa052050.96956112
43Amoebiasis_Homo sapiens_hsa051460.95860066
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95603804
45p53 signaling pathway_Homo sapiens_hsa041150.94521490
46N-Glycan biosynthesis_Homo sapiens_hsa005100.92824755
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91846871
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91488821
49Endocytosis_Homo sapiens_hsa041440.90786160
50Salmonella infection_Homo sapiens_hsa051320.88320430
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86364425
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85949890
53Parkinsons disease_Homo sapiens_hsa050120.82605590
54Nucleotide excision repair_Homo sapiens_hsa034200.82132893
55Pyrimidine metabolism_Homo sapiens_hsa002400.81556885
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80755240
57Osteoclast differentiation_Homo sapiens_hsa043800.80396460
58B cell receptor signaling pathway_Homo sapiens_hsa046620.80323114
59Gap junction_Homo sapiens_hsa045400.79304631
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78595910
61Thyroid cancer_Homo sapiens_hsa052160.73465889
62Collecting duct acid secretion_Homo sapiens_hsa049660.73191431
63Fructose and mannose metabolism_Homo sapiens_hsa000510.72811550
64Chronic myeloid leukemia_Homo sapiens_hsa052200.72336423
65Oxidative phosphorylation_Homo sapiens_hsa001900.71668299
66Pancreatic cancer_Homo sapiens_hsa052120.68999997
67Legionellosis_Homo sapiens_hsa051340.68097280
68Toxoplasmosis_Homo sapiens_hsa051450.67477855
69Dilated cardiomyopathy_Homo sapiens_hsa054140.67280116
70Complement and coagulation cascades_Homo sapiens_hsa046100.67019460
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66926537
72Proteasome_Homo sapiens_hsa030500.66924777
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.65239035
74HTLV-I infection_Homo sapiens_hsa051660.63849402
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.63616536
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63159888
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62044108
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60361230
79Sulfur metabolism_Homo sapiens_hsa009200.58416515
80Huntingtons disease_Homo sapiens_hsa050160.56598443
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55548627
82Viral carcinogenesis_Homo sapiens_hsa052030.55312638
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.54621541
84Insulin signaling pathway_Homo sapiens_hsa049100.52862320
85Rheumatoid arthritis_Homo sapiens_hsa053230.52451419
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51940777
87Acute myeloid leukemia_Homo sapiens_hsa052210.49496959
88Hepatitis B_Homo sapiens_hsa051610.47339634
89TNF signaling pathway_Homo sapiens_hsa046680.44974235
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44709021
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43515455
92Chemokine signaling pathway_Homo sapiens_hsa040620.43406547
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42872364
94Influenza A_Homo sapiens_hsa051640.41435069
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41186432
96Oocyte meiosis_Homo sapiens_hsa041140.40619759
97Peroxisome_Homo sapiens_hsa041460.40038901
98Hepatitis C_Homo sapiens_hsa051600.39974655
99Endometrial cancer_Homo sapiens_hsa052130.38713441
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37214899

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