WBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.68135585
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.68135585
3L-phenylalanine metabolic process (GO:0006558)4.66751873
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.66751873
5cellular ketone body metabolic process (GO:0046950)4.61808394
6glyoxylate metabolic process (GO:0046487)4.33528590
7sulfur amino acid catabolic process (GO:0000098)4.17382542
8viral transcription (GO:0019083)4.15270468
9ketone body metabolic process (GO:1902224)4.14087632
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.10043201
11axonemal dynein complex assembly (GO:0070286)4.04597988
12semaphorin-plexin signaling pathway (GO:0071526)4.02075577
13regulation of somitogenesis (GO:0014807)3.92020002
14ATP synthesis coupled proton transport (GO:0015986)3.89422230
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89422230
16lysine metabolic process (GO:0006553)3.83354781
17lysine catabolic process (GO:0006554)3.83354781
18translational termination (GO:0006415)3.79720229
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.78231642
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77045320
21pyrimidine nucleobase catabolic process (GO:0006208)3.76777152
22ethanol oxidation (GO:0006069)3.74291774
23protein targeting to ER (GO:0045047)3.66832106
24protein retention in ER lumen (GO:0006621)3.66745621
25cotranslational protein targeting to membrane (GO:0006613)3.66393569
26fatty acid beta-oxidation (GO:0006635)3.60663712
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.49433200
28motile cilium assembly (GO:0044458)3.49089678
29ribosomal small subunit assembly (GO:0000028)3.44099326
30alpha-linolenic acid metabolic process (GO:0036109)3.42205395
31short-chain fatty acid metabolic process (GO:0046459)3.41440931
32protein localization to endoplasmic reticulum (GO:0070972)3.41095831
33aromatic amino acid family catabolic process (GO:0009074)3.40910124
34tricarboxylic acid metabolic process (GO:0072350)3.40605412
35left/right pattern formation (GO:0060972)3.39287272
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38037571
37translational elongation (GO:0006414)3.36222440
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.35765800
39axon extension involved in axon guidance (GO:0048846)3.26437125
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.26437125
41fatty acid oxidation (GO:0019395)3.23602286
42Golgi transport vesicle coating (GO:0048200)3.22410371
43COPI coating of Golgi vesicle (GO:0048205)3.22410371
44camera-type eye morphogenesis (GO:0048593)3.22145911
45fatty acid catabolic process (GO:0009062)3.21338908
46cell migration in hindbrain (GO:0021535)3.20914101
47pentose-phosphate shunt (GO:0006098)3.19338428
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18391421
49NADPH regeneration (GO:0006740)3.16499961
50lipid oxidation (GO:0034440)3.12896023
51viral life cycle (GO:0019058)3.12078507
52cell-cell junction maintenance (GO:0045217)3.08230245
532-oxoglutarate metabolic process (GO:0006103)3.00950533
54dendritic spine morphogenesis (GO:0060997)2.99744538
55acetyl-CoA metabolic process (GO:0006084)2.96875832
56cilium or flagellum-dependent cell motility (GO:0001539)2.95816002
57aspartate family amino acid catabolic process (GO:0009068)2.94819064
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94188924
59negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.93568994
60proline biosynthetic process (GO:0006561)2.92210288
61lung epithelium development (GO:0060428)2.91709481
62mannose metabolic process (GO:0006013)2.91582347
63branched-chain amino acid catabolic process (GO:0009083)2.91575333
64purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.91302543
65ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.91302543
66nucleoside bisphosphate biosynthetic process (GO:0033866)2.91302543
67exocrine pancreas development (GO:0031017)2.89679430
68coenzyme A metabolic process (GO:0015936)2.88566167
69peptidyl-tyrosine autophosphorylation (GO:0038083)2.87193215
70regulation of synapse structural plasticity (GO:0051823)2.86691688
71protein insertion into membrane (GO:0051205)2.86107298
72negative regulation of cholesterol transport (GO:0032375)2.84730182
73negative regulation of sterol transport (GO:0032372)2.84730182
74positive regulation of fatty acid beta-oxidation (GO:0032000)2.82984580
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82832330
76heme biosynthetic process (GO:0006783)2.82298936
77monocarboxylic acid catabolic process (GO:0072329)2.80720621
78electron transport chain (GO:0022900)2.80133563
79cilium movement (GO:0003341)2.79912306
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.78889156
81respiratory electron transport chain (GO:0022904)2.78613100
824-hydroxyproline metabolic process (GO:0019471)2.78402821
83amyloid precursor protein catabolic process (GO:0042987)2.78123040
84endothelial cell chemotaxis (GO:0035767)2.77960961
85proline metabolic process (GO:0006560)2.77582205
86GDP-mannose metabolic process (GO:0019673)2.77433468
87branched-chain amino acid metabolic process (GO:0009081)2.77248650
88maternal placenta development (GO:0001893)2.76703146
89cysteine metabolic process (GO:0006534)2.76446368
90intestinal cholesterol absorption (GO:0030299)2.75815527
91cellular protein complex disassembly (GO:0043624)2.75417912
92protein complex disassembly (GO:0043241)2.72603285
93negative regulation of cell size (GO:0045792)2.70826211
94pentose metabolic process (GO:0019321)2.69910633
95ethanol metabolic process (GO:0006067)2.69829304
96biotin metabolic process (GO:0006768)2.69531006
97nucleosome disassembly (GO:0006337)2.69042690
98protein-DNA complex disassembly (GO:0032986)2.69042690
99response to mercury ion (GO:0046689)2.68030501
100regulation of skeletal muscle contraction (GO:0014819)2.67437788
101kynurenine metabolic process (GO:0070189)2.66304797
102regulation of fatty acid beta-oxidation (GO:0031998)2.65417274
103positive regulation of triglyceride biosynthetic process (GO:0010867)2.65004136
104dosage compensation (GO:0007549)2.64480385
105positive regulation of fatty acid oxidation (GO:0046321)2.63965026
106regulation of fatty acid oxidation (GO:0046320)2.63591050
107ribosomal small subunit biogenesis (GO:0042274)2.62864510
108regulation of chromatin binding (GO:0035561)2.62378696
109negative regulation of catenin import into nucleus (GO:0035414)2.60425168
110ear development (GO:0043583)2.60118855
111cochlea morphogenesis (GO:0090103)2.59974113
112macromolecular complex disassembly (GO:0032984)2.58367544
113convergent extension (GO:0060026)2.58033414
114lung morphogenesis (GO:0060425)2.57104631
115nucleobase catabolic process (GO:0046113)2.56494587
116regulation of ARF GTPase activity (GO:0032312)2.54784069
117negative regulation of erythrocyte differentiation (GO:0045647)2.53366796
118drug transmembrane transport (GO:0006855)2.53024149
119inner mitochondrial membrane organization (GO:0007007)2.52260555
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52253639
121epithelial cilium movement (GO:0003351)2.52133822
122protein targeting to membrane (GO:0006612)2.52111308
123auditory receptor cell differentiation (GO:0042491)2.51487529
124aromatic amino acid family metabolic process (GO:0009072)2.51044341
125Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50010028
126positive regulation of oligodendrocyte differentiation (GO:0048714)2.49560428
127tricarboxylic acid cycle (GO:0006099)2.47834506
128nucleoside bisphosphate metabolic process (GO:0033865)2.47784328
129purine nucleoside bisphosphate metabolic process (GO:0034032)2.47784328
130ribonucleoside bisphosphate metabolic process (GO:0033875)2.47784328
131tyrosine metabolic process (GO:0006570)2.47600597
132myelination in peripheral nervous system (GO:0022011)2.47188474
133peripheral nervous system axon ensheathment (GO:0032292)2.47188474
134primitive streak formation (GO:0090009)2.46535109
135UV protection (GO:0009650)2.46423851
136bile acid biosynthetic process (GO:0006699)2.46306879
137regulation of glycogen (starch) synthase activity (GO:2000465)2.46306038
138histone H4 deacetylation (GO:0070933)2.45951401
139protoporphyrinogen IX metabolic process (GO:0046501)2.45363345
140neuronal ion channel clustering (GO:0045161)2.44857544
141oxidative phosphorylation (GO:0006119)2.44374627
142organic acid catabolic process (GO:0016054)2.43899292
143apoptotic process involved in morphogenesis (GO:0060561)2.42239372
144atrioventricular valve morphogenesis (GO:0003181)2.40731884
145cranial nerve morphogenesis (GO:0021602)2.38194355
146phosphatidylglycerol biosynthetic process (GO:0006655)2.36207084
147dendritic spine organization (GO:0097061)2.34956208
148dermatan sulfate metabolic process (GO:0030205)2.34954880
149regulation of cholesterol biosynthetic process (GO:0045540)2.34749781
150activation of MAPKKK activity (GO:0000185)2.33983390
151establishment of mitochondrion localization (GO:0051654)2.33403831
152regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32358252
153mitochondrion transport along microtubule (GO:0047497)2.32300440
154establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.32300440
155regulation of establishment of planar polarity (GO:0090175)2.31118925
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.30426688
157substrate-independent telencephalic tangential migration (GO:0021826)2.30426688
158adenine nucleotide transport (GO:0051503)2.29568074
159mesonephros development (GO:0001823)2.29284808
160apoptotic process involved in development (GO:1902742)2.27279665
161axon extension (GO:0048675)2.26159355
162regulation of cholesterol metabolic process (GO:0090181)2.26127643
163cell junction maintenance (GO:0034331)2.25359654
164primary alcohol catabolic process (GO:0034310)2.24783615
165telencephalon development (GO:0021537)2.24076381
166skeletal muscle organ development (GO:0060538)2.18709130
167histone H3 deacetylation (GO:0070932)2.18634568
168regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.18187326
169detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.16781729
170detection of temperature stimulus involved in sensory perception (GO:0050961)2.16781729
171urogenital system development (GO:0001655)2.16402136
172positive regulation of gastrulation (GO:2000543)2.15756880
173positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.15402593
174osteoblast development (GO:0002076)2.15108973
175cellular response to virus (GO:0098586)2.12458677
176negative regulation of smoothened signaling pathway (GO:0045879)2.11068261
177sensory perception of taste (GO:0050909)2.10974190
178bone development (GO:0060348)2.10680410
179cell volume homeostasis (GO:0006884)2.10670241
180neuron projection regeneration (GO:0031102)2.09821863
181negative regulation of cartilage development (GO:0061037)2.09672983
182positive regulation of smoothened signaling pathway (GO:0045880)2.07740965
183adenosine receptor signaling pathway (GO:0001973)2.07451770
184purine nucleotide transport (GO:0015865)2.07390720
185renal system development (GO:0072001)2.05897678
186spinal cord association neuron differentiation (GO:0021527)2.05612685
187protein carboxylation (GO:0018214)2.05165622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.33205068
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.86535093
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04845881
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98694931
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.82942790
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.82373013
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.78415853
8* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.70810377
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61383509
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.55995705
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.52917140
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.36569154
13* VDR_21846776_ChIP-Seq_THP-1_Human2.35884428
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.33441343
15LXR_22292898_ChIP-Seq_THP-1_Human2.21184069
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.09225284
17CTCF_27219007_Chip-Seq_Bcells_Human2.07545515
18* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.99407883
19* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.97707840
20KDM2B_26808549_Chip-Seq_K562_Human1.97166124
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.93083847
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87163163
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87101331
24EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.86392030
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85451751
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83849176
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.82104459
28SMC4_20622854_ChIP-Seq_HELA_Human1.81593073
29MYC_22102868_ChIP-Seq_BL_Human1.80349901
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78834360
31DROSHA_22980978_ChIP-Seq_HELA_Human1.71631115
32ZNF263_19887448_ChIP-Seq_K562_Human1.70280409
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68997118
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68160394
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67848869
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.67717156
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66496880
38XRN2_22483619_ChIP-Seq_HELA_Human1.64930746
39EZH2_22144423_ChIP-Seq_EOC_Human1.63703448
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61168107
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60847447
42* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60089718
43CLOCK_20551151_ChIP-Seq_293T_Human1.58479282
44* TET1_21451524_ChIP-Seq_MESCs_Mouse1.56843991
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55799149
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54814946
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54108444
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53718133
49MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.53643091
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51927959
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47648239
52CIITA_25753668_ChIP-Seq_RAJI_Human1.46151095
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43369424
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43299913
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43150879
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43150879
57* RUNX1_27514584_Chip-Seq_MCF-7_Human1.42285893
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.42204217
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.42128197
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39410141
61RACK7_27058665_Chip-Seq_MCF-7_Human1.38534245
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38055467
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.36223695
64* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35567007
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.33264973
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30090395
67PHF8_20622854_ChIP-Seq_HELA_Human1.28905234
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27212194
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26959038
70* VDR_24763502_ChIP-Seq_THP-1_Human1.26562082
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25795673
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25709445
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.24763763
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.24372614
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24093729
76* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23984464
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.23648723
78FOXP1_21924763_ChIP-Seq_HESCs_Human1.23273783
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22912894
80SCL_19346495_ChIP-Seq_HPC-7_Human1.22847608
81TP53_22127205_ChIP-Seq_IMR90_Human1.22783159
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.22631758
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22468139
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.22372493
85TP63_22573176_ChIP-Seq_HFKS_Human1.22283927
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21828856
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21777195
88P68_20966046_ChIP-Seq_HELA_Human1.21126084
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21020683
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20871953
91SA1_27219007_Chip-Seq_Bcells_Human1.20393769
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.18850653
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18405142
94CTCF_21964334_Chip-Seq_Bcells_Human1.18230647
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18009402
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17636796
97MYC_18555785_ChIP-Seq_MESCs_Mouse1.17492269
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17420046
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17019175
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16701274
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16366236
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15714384
103* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14880418
104* MAF_26560356_Chip-Seq_TH2_Human1.14741326
105BCOR_27268052_Chip-Seq_Bcells_Human1.14078087
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13527575
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13067710
108* TCF7_22412390_ChIP-Seq_EML_Mouse1.12709817
109* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12104269
110EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11610410
111* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10765861
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10750511
113JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10210525
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.09952349
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.09252253
116RARA_24833708_ChIP-Seq_LIVER_Mouse1.09169859
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08488787
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08231357
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07506298
120BCL6_27268052_Chip-Seq_Bcells_Human1.06864517
121GABP_19822575_ChIP-Seq_HepG2_Human1.06672670
122KDM2B_26808549_Chip-Seq_DND41_Human1.06590256
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06419290
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06120514
125* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05815426
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05777513
127GABP_17652178_ChIP-ChIP_JURKAT_Human1.05058935
128* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05037762
129OCT4_19829295_ChIP-Seq_ESCs_Human1.04771818
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04681668
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04459073
132RING1B_27294783_Chip-Seq_ESCs_Mouse1.03789943
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02026948
134TET1_21490601_ChIP-Seq_MESCs_Mouse1.01955713
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01533416
136CREB1_26743006_Chip-Seq_LNCaP_Human1.01300315
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00841923
138CTCF_20526341_ChIP-Seq_ESCs_Human1.00604644
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00553100
140ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00509533
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99987602
142STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99594226
143RARB_27405468_Chip-Seq_BRAIN_Mouse0.99257745
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99218636
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98946840
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98505585
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98296783
148CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98014269
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97200304
150ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97050022
151UTX_26944678_Chip-Seq_JUKART_Human0.96781222
152E2F1_20622854_ChIP-Seq_HELA_Human0.95875200
153CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95356947
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94420873
155RARB_24833708_ChIP-Seq_LIVER_Mouse0.94309690
156TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94089733
157* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93979604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.06717442
2MP0010030_abnormal_orbit_morphology4.03340283
3MP0005360_urolithiasis3.58508286
4MP0003283_abnormal_digestive_organ3.57215225
5MP0005365_abnormal_bile_salt3.33248011
6MP0009379_abnormal_foot_pigmentation3.28156578
7MP0002822_catalepsy2.92864827
8MP0001666_abnormal_nutrient_absorption2.80794289
9MP0005377_hearing/vestibular/ear_phenot2.74435197
10MP0003878_abnormal_ear_physiology2.74435197
11MP0005409_darkened_coat_color2.62472074
12MP0005423_abnormal_somatic_nervous2.61685421
13MP0000537_abnormal_urethra_morphology2.58849157
14MP0002837_dystrophic_cardiac_calcinosis2.57740827
15MP0005085_abnormal_gallbladder_physiolo2.53889055
16MP0005220_abnormal_exocrine_pancreas2.48983011
17MP0003806_abnormal_nucleotide_metabolis2.45686225
18MP0008789_abnormal_olfactory_epithelium2.41222775
19MP0003136_yellow_coat_color2.41209426
20MP0008875_abnormal_xenobiotic_pharmacok2.36669668
21MP0005083_abnormal_biliary_tract2.32264477
22MP0003123_paternal_imprinting2.12204234
23MP0009840_abnormal_foam_cell2.09043334
24MP0004858_abnormal_nervous_system1.95491743
25MP0004043_abnormal_pH_regulation1.89253804
26MP0004859_abnormal_synaptic_plasticity1.88073688
27MP0003252_abnormal_bile_duct1.85086523
28MP0009053_abnormal_anal_canal1.76267138
29MP0002653_abnormal_ependyma_morphology1.72633073
30MP0001502_abnormal_circadian_rhythm1.72312348
31MP0000462_abnormal_digestive_system1.69716260
32MP0009780_abnormal_chondrocyte_physiolo1.69523896
33MP0009643_abnormal_urine_homeostasis1.59592183
34MP0002938_white_spotting1.52566032
35MP0001293_anophthalmia1.48034079
36MP0002249_abnormal_larynx_morphology1.46621468
37MP0001485_abnormal_pinna_reflex1.45684077
38MP0002932_abnormal_joint_morphology1.42270730
39MP0000049_abnormal_middle_ear1.42030621
40MP0006292_abnormal_olfactory_placode1.41787041
41MP0006036_abnormal_mitochondrial_physio1.37656842
42MP0001984_abnormal_olfaction1.36497071
43MP0000750_abnormal_muscle_regeneration1.35205384
44MP0002234_abnormal_pharynx_morphology1.31653462
45MP0003942_abnormal_urinary_system1.30909227
46MP0000678_abnormal_parathyroid_gland1.29805307
47MP0001944_abnormal_pancreas_morphology1.29426087
48MP0003879_abnormal_hair_cell1.29021398
49MP0005394_taste/olfaction_phenotype1.28895368
50MP0005499_abnormal_olfactory_system1.28895368
51MP0005332_abnormal_amino_acid1.28261679
52MP0000778_abnormal_nervous_system1.27148609
53MP0002116_abnormal_craniofacial_bone1.26412730
54MP0001348_abnormal_lacrimal_gland1.23850639
55MP0005084_abnormal_gallbladder_morpholo1.22454050
56MP0005503_abnormal_tendon_morphology1.22187802
57MP0005636_abnormal_mineral_homeostasis1.21424269
58MP0003656_abnormal_erythrocyte_physiolo1.20391506
59MP0000003_abnormal_adipose_tissue1.19921442
60MP0010329_abnormal_lipoprotein_level1.19764959
61MP0000566_synostosis1.18450848
62MP0009384_cardiac_valve_regurgitation1.17204712
63MP0000490_abnormal_crypts_of1.16751615
64MP0000026_abnormal_inner_ear1.14501342
65MP0004133_heterotaxia1.13942575
66MP0001849_ear_inflammation1.13248859
67MP0003315_abnormal_perineum_morphology1.10377583
68MP0002118_abnormal_lipid_homeostasis1.08711371
69MP0004130_abnormal_muscle_cell1.08462013
70MP0002089_abnormal_postnatal_growth/wei1.07129609
71MP0002092_abnormal_eye_morphology1.05338807
72MP0003137_abnormal_impulse_conducting1.05277041
73MP0001986_abnormal_taste_sensitivity1.05187799
74MP0005319_abnormal_enzyme/_coenzyme1.04119531
75MP0005076_abnormal_cell_differentiation1.02151138
76MP0000534_abnormal_ureter_morphology1.01889875
77MP0003172_abnormal_lysosome_physiology1.01383674
78MP0003119_abnormal_digestive_system0.99850345
79MP0006054_spinal_hemorrhage0.99451110
80MP0003122_maternal_imprinting0.99359787
81MP0005171_absent_coat_pigmentation0.98579725
82MP0003705_abnormal_hypodermis_morpholog0.97678058
83MP0000609_abnormal_liver_physiology0.97598886
84MP0009278_abnormal_bone_marrow0.97117001
85MP0003567_abnormal_fetal_cardiomyocyte0.96303031
86MP0000955_abnormal_spinal_cord0.95553218
87MP0006138_congestive_heart_failure0.94878999
88MP0003938_abnormal_ear_development0.94507290
89MP0000163_abnormal_cartilage_morphology0.94202236
90MP0005670_abnormal_white_adipose0.92699488
91MP0003279_aneurysm0.92556358
92MP0003329_amyloid_beta_deposits0.92038405
93MP0003385_abnormal_body_wall0.91997635
94MP0005508_abnormal_skeleton_morphology0.91770370
95MP0003191_abnormal_cellular_cholesterol0.91206405
96MP0002102_abnormal_ear_morphology0.90927553
97MP0002063_abnormal_learning/memory/cond0.90633078
98MP0000733_abnormal_muscle_development0.90156632
99MP0005584_abnormal_enzyme/coenzyme_acti0.89475790
100MP0009250_abnormal_appendicular_skeleto0.89375366
101MP0000467_abnormal_esophagus_morphology0.88869314
102MP0004381_abnormal_hair_follicle0.88729825
103MP0000579_abnormal_nail_morphology0.87580847
104MP0004019_abnormal_vitamin_homeostasis0.87275407
105MP0000538_abnormal_urinary_bladder0.86930364
106MP0002233_abnormal_nose_morphology0.86274852
107MP0003635_abnormal_synaptic_transmissio0.86232160
108MP0000762_abnormal_tongue_morphology0.86099089
109MP0010368_abnormal_lymphatic_system0.85320708
110MP0006276_abnormal_autonomic_nervous0.85233010
111MP0002108_abnormal_muscle_morphology0.85150828
112MP0000477_abnormal_intestine_morphology0.84896454
113MP0000681_abnormal_thyroid_gland0.84211328
114MP0002751_abnormal_autonomic_nervous0.84079429
115MP0008260_abnormal_autophagy0.83495773
116MP0001958_emphysema0.83439588
117MP0001270_distended_abdomen0.82902159
118MP0009672_abnormal_birth_weight0.82389482
119MP0003011_delayed_dark_adaptation0.81628661
120MP0000751_myopathy0.81409250
121MP0000598_abnormal_liver_morphology0.81089512
122MP0002152_abnormal_brain_morphology0.79762867
123MP0005375_adipose_tissue_phenotype0.77163564
124MP0001970_abnormal_pain_threshold0.77056194
125MP0003868_abnormal_feces_composition0.75875615
126MP0002282_abnormal_trachea_morphology0.75489308
127MP0003959_abnormal_lean_body0.75462767
128MP0003861_abnormal_nervous_system0.75152166
129MP0001756_abnormal_urination0.73769218
130MP0001340_abnormal_eyelid_morphology0.72627195
131MP0002882_abnormal_neuron_morphology0.72445434
132MP0000428_abnormal_craniofacial_morphol0.72272736
133MP0002138_abnormal_hepatobiliary_system0.72178367
134MP0010630_abnormal_cardiac_muscle0.72124389
135MP0002572_abnormal_emotion/affect_behav0.71629184
136MP0001963_abnormal_hearing_physiology0.71184445
137MP0005501_abnormal_skin_physiology0.71120649
138MP0005330_cardiomyopathy0.71091958
139MP0005646_abnormal_pituitary_gland0.70547806
140MP0000767_abnormal_smooth_muscle0.69890040
141MP0002909_abnormal_adrenal_gland0.69595111
142MP0003186_abnormal_redox_activity0.69432799
143MP0004185_abnormal_adipocyte_glucose0.69225429
144MP0005187_abnormal_penis_morphology0.68517337
145MP0002132_abnormal_respiratory_system0.68269864
146MP0002697_abnormal_eye_size0.67841668
147MP0004084_abnormal_cardiac_muscle0.67808229
148MP0004264_abnormal_extraembryonic_tissu0.67413821
149MP0005666_abnormal_adipose_tissue0.66609977
150MP0000613_abnormal_salivary_gland0.65779256
151MP0002752_abnormal_somatic_nervous0.64967712
152MP0002078_abnormal_glucose_homeostasis0.64133482
153MP0002933_joint_inflammation0.63922499
154MP0001968_abnormal_touch/_nociception0.63828325
155MP0002557_abnormal_social/conspecific_i0.63742829
156MP0003948_abnormal_gas_homeostasis0.63132633
157MP0005381_digestive/alimentary_phenotyp0.62364453
158MP0004087_abnormal_muscle_fiber0.62112650
159MP0005058_abnormal_lysosome_morphology0.60961654
160MP0003115_abnormal_respiratory_system0.60445055
161MP0002638_abnormal_pupillary_reflex0.60270004
162MP0002111_abnormal_tail_morphology0.59695377

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.72469373
2Obstructive sleep apnea (HP:0002870)4.45352907
3Anomalous pulmonary venous return (HP:0010772)3.91623805
4Ketosis (HP:0001946)3.84680394
5Ketoacidosis (HP:0001993)3.73965371
6J-shaped sella turcica (HP:0002680)3.58514631
7Hypoglycemic coma (HP:0001325)3.58398035
8Dicarboxylic aciduria (HP:0003215)3.55026843
9Abnormality of dicarboxylic acid metabolism (HP:0010995)3.55026843
10Abnormal respiratory motile cilium morphology (HP:0005938)3.48041833
11Abnormal respiratory epithelium morphology (HP:0012253)3.48041833
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.47903257
13Cervical subluxation (HP:0003308)3.46989696
14Delayed CNS myelination (HP:0002188)3.42081798
15Abnormality of fatty-acid metabolism (HP:0004359)3.32242409
16Turricephaly (HP:0000262)3.30884699
17Abnormality of the pulmonary veins (HP:0011718)3.29876574
18Acute encephalopathy (HP:0006846)3.28306743
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16718408
20Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.13544028
21Hyperammonemia (HP:0001987)3.09795212
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.08249875
23Absent/shortened dynein arms (HP:0200106)3.08249875
24Thin bony cortex (HP:0002753)3.07001381
25Annular pancreas (HP:0001734)2.99354003
26Late onset (HP:0003584)2.95307381
27Abnormal mitochondria in muscle tissue (HP:0008316)2.93912232
28Abnormal respiratory motile cilium physiology (HP:0012261)2.92603336
29Hepatic necrosis (HP:0002605)2.92191460
30Acute necrotizing encephalopathy (HP:0006965)2.92122346
31Generalized aminoaciduria (HP:0002909)2.84938466
32Reticulocytopenia (HP:0001896)2.82705002
33Abnormal ciliary motility (HP:0012262)2.80854441
34Short femoral neck (HP:0100864)2.80317651
35Abnormality of the aortic arch (HP:0012303)2.77689033
36Hemorrhage of the eye (HP:0011885)2.76266710
37Rib fusion (HP:0000902)2.72835263
38Atelectasis (HP:0100750)2.71055732
39Gout (HP:0001997)2.69721726
40Aortic regurgitation (HP:0001659)2.65530293
41Cerebral edema (HP:0002181)2.65371770
42Abnormality of glycine metabolism (HP:0010895)2.64534484
43Abnormality of serine family amino acid metabolism (HP:0010894)2.64534484
44Hyperglycinuria (HP:0003108)2.58308984
45Broad face (HP:0000283)2.55837483
46Hyperglycinemia (HP:0002154)2.55691110
47Palpitations (HP:0001962)2.53175252
48Abnormality of cells of the erythroid lineage (HP:0012130)2.50603101
49Nasal polyposis (HP:0100582)2.49654503
50Mitochondrial inheritance (HP:0001427)2.45379926
51Increased muscle lipid content (HP:0009058)2.44025251
52Abnormality of endocrine pancreas physiology (HP:0012093)2.41267548
53Abnormality of the pancreatic islet cells (HP:0006476)2.41267548
54Hepatocellular necrosis (HP:0001404)2.40223075
55Visceral angiomatosis (HP:0100761)2.39761471
56Deep venous thrombosis (HP:0002625)2.37210371
57Hyperacusis (HP:0010780)2.34352573
58Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.34273214
59Aplasia/hypoplasia of the femur (HP:0005613)2.33726851
60Myokymia (HP:0002411)2.33149459
61Xanthomatosis (HP:0000991)2.32471823
62Joint stiffness (HP:0001387)2.31160287
63Broad metatarsal (HP:0001783)2.29725554
64Hypobetalipoproteinemia (HP:0003563)2.28245716
65Shallow orbits (HP:0000586)2.27014585
66Abnormal number of erythroid precursors (HP:0012131)2.26570857
67Abnormality of the odontoid process (HP:0003310)2.26159798
68Lethargy (HP:0001254)2.25042171
69Metabolic acidosis (HP:0001942)2.24885116
70Lymphangioma (HP:0100764)2.24724331
71Myoglobinuria (HP:0002913)2.23676319
72Urinary glycosaminoglycan excretion (HP:0003541)2.22945328
73Mucopolysacchariduria (HP:0008155)2.22945328
74Mitral regurgitation (HP:0001653)2.22766231
75Abnormality of the 1st metacarpal (HP:0010009)2.22641053
76Rhinitis (HP:0012384)2.22585617
77Sleep apnea (HP:0010535)2.18959749
78Vomiting (HP:0002013)2.18592828
79Sudden death (HP:0001699)2.17962740
80Deformed sella turcica (HP:0002681)2.17448268
81Insomnia (HP:0100785)2.17366446
82Occipital encephalocele (HP:0002085)2.16882569
83Renal duplication (HP:0000075)2.14859447
84Progressive macrocephaly (HP:0004481)2.13202084
85Lactic acidosis (HP:0003128)2.12897436
86Hemangiomatosis (HP:0007461)2.12867998
87Methylmalonic aciduria (HP:0012120)2.12815136
88Protrusio acetabuli (HP:0003179)2.11898208
89Abnormality of the nasal mucosa (HP:0000433)2.11836918
90Broad distal phalanx of finger (HP:0009836)2.10620370
91Abnormality of the intervertebral disk (HP:0005108)2.08809659
92Hypercortisolism (HP:0001578)2.07017681
93Bronchomalacia (HP:0002780)2.06851809
94Bell-shaped thorax (HP:0001591)2.05981270
95Coronal craniosynostosis (HP:0004440)2.04836136
96Renal dysplasia (HP:0000110)2.04676025
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03518204
98Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03518204
99Abnormality of polysaccharide metabolism (HP:0011012)2.03518204
100Down-sloping shoulders (HP:0200021)2.03066725
101Spinal canal stenosis (HP:0003416)2.02987339
102Distal lower limb muscle weakness (HP:0009053)2.02538620
103Hyperbilirubinemia (HP:0002904)2.02471204
104Aplasia of the musculature (HP:0100854)2.00050966
105Respiratory failure (HP:0002878)1.99849442
106Intrahepatic cholestasis (HP:0001406)1.99274359
107Ventricular tachycardia (HP:0004756)1.99255833
108Flat acetabular roof (HP:0003180)1.96666463
109Stridor (HP:0010307)1.96558346
110Opisthotonus (HP:0002179)1.96005443
111Increased intramyocellular lipid droplets (HP:0012240)1.95357556
112Multiple enchondromatosis (HP:0005701)1.94868403
113Ulnar bowing (HP:0003031)1.93796271
114Abnormality of the intrinsic pathway (HP:0010989)1.93421552
115Abnormal cartilage morphology (HP:0002763)1.92573236
116Increased CSF lactate (HP:0002490)1.92404298
117Biconcave vertebral bodies (HP:0004586)1.92312367
118Upper limb amyotrophy (HP:0009129)1.90603740
119Distal upper limb amyotrophy (HP:0007149)1.90603740
120Glycosuria (HP:0003076)1.90570416
121Abnormality of urine glucose concentration (HP:0011016)1.90570416
122Right ventricular cardiomyopathy (HP:0011663)1.90499822
123Dysostosis multiplex (HP:0000943)1.87743567
124Cerebral palsy (HP:0100021)1.87642002
125Pancreatic islet-cell hyperplasia (HP:0004510)1.85153427
126Partial duplication of the phalanx of hand (HP:0009999)1.84936542
127Goiter (HP:0000853)1.84333828
128Testicular atrophy (HP:0000029)1.83895209
129Partial duplication of thumb phalanx (HP:0009944)1.82794365
130Long toe (HP:0010511)1.82185212
131Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82070999
132Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82070999
133Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81432726
134Ileus (HP:0002595)1.81353168
135Abnormality of the thoracic spine (HP:0100711)1.80959444
136Ankle clonus (HP:0011448)1.80633495
137Myelomeningocele (HP:0002475)1.80497154
138Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.80447147
139Chronic bronchitis (HP:0004469)1.80060185
140Thin ribs (HP:0000883)1.78737184
141Hand muscle atrophy (HP:0009130)1.78471927
142Rhabdomyolysis (HP:0003201)1.76941959
143Neoplasm of the adrenal gland (HP:0100631)1.76542752
144Cavernous hemangioma (HP:0001048)1.76077284
145Cardiomegaly (HP:0001640)1.76074293
146Short phalanx of the thumb (HP:0009660)1.75883917
147Back pain (HP:0003418)1.75029341
148Male infertility (HP:0003251)1.74844052
149Proximal tubulopathy (HP:0000114)1.74762391
150Concave nail (HP:0001598)1.74647607
151Prominent occiput (HP:0000269)1.74496680
152Overriding aorta (HP:0002623)1.74000651
153Hyperinsulinemic hypoglycemia (HP:0000825)1.73307696
154Alacrima (HP:0000522)1.73060315
155Abnormality of the heme biosynthetic pathway (HP:0010472)1.72413026
156Large for gestational age (HP:0001520)1.71643460
157Short thorax (HP:0010306)1.71125181
158Spina bifida occulta (HP:0003298)1.70557574
159Neonatal onset (HP:0003623)1.70266294
160Thoracic kyphosis (HP:0002942)1.69257110
161Hyperphosphaturia (HP:0003109)1.68738460
162Congenital glaucoma (HP:0001087)1.68617540
163Flattened epiphyses (HP:0003071)1.68533073
164Myopathic facies (HP:0002058)1.68243928
165Pointed chin (HP:0000307)1.68226316
166Vaginal fistula (HP:0004320)1.67627113
167Lipoatrophy (HP:0100578)1.67417974
168Easy fatigability (HP:0003388)1.67370485
169Rectal prolapse (HP:0002035)1.66582052
170Abdominal distention (HP:0003270)1.66089462
171Prolonged QT interval (HP:0001657)1.65740750
172Conjunctival hamartoma (HP:0100780)1.65001108
173Lipid accumulation in hepatocytes (HP:0006561)1.64897200
174Hypoglycemic seizures (HP:0002173)1.64699353
175Hyperlipoproteinemia (HP:0010980)1.63952594
176Abnormality of purine metabolism (HP:0004352)1.63258379
177Dilated cardiomyopathy (HP:0001644)1.63249547
178Pallor (HP:0000980)1.62316846
179Elfin facies (HP:0004428)1.62297709
180Abnormality of carpal bone ossification (HP:0006257)1.60839381
181Meningocele (HP:0002435)1.60330679
182Hyperthyroidism (HP:0000836)1.59862062
183Periauricular skin pits (HP:0100277)1.59129667
184Preauricular pit (HP:0004467)1.59129667
185Mesangial abnormality (HP:0001966)1.58615748
186Morphological abnormality of the middle ear (HP:0008609)1.58057208
187Aplasia involving bones of the extremities (HP:0009825)1.58002743
188Aplasia involving bones of the upper limbs (HP:0009823)1.58002743
189Aplasia of the phalanges of the hand (HP:0009802)1.58002743
190Infertility (HP:0000789)1.57629880
191Neoplasm of the heart (HP:0100544)1.57291425
192Slow saccadic eye movements (HP:0000514)1.56106497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.13174821
2TRIB33.79027711
3ERN12.95757057
4BLK2.91289463
5EPHB22.71704908
6MAP3K102.60169099
7TLK12.38553958
8DYRK32.33470796
9EPHA22.21789745
10FLT32.19293167
11MAPK152.15645179
12PKN22.11749302
13DYRK1B2.08767153
14WNK42.02419552
15STK162.02176915
16PRKD31.99356653
17SIK11.97234365
18MST1R1.93082184
19ICK1.84765433
20MAP2K21.84630469
21UHMK11.80325836
22EEF2K1.77152420
23ILK1.72352661
24SMG11.63825756
25LRRK21.58340324
26DYRK21.54316151
27NME21.53218742
28RPS6KA21.50856327
29TYRO31.45382910
30SIK21.44838915
31ERBB31.44835991
32RPS6KL11.39194064
33RPS6KC11.39194064
34PRPF4B1.36075966
35MUSK1.35928730
36MET1.33992054
37MYLK1.33037037
38NTRK21.27948608
39NTRK11.27860912
40ERBB21.25266730
41MAP3K61.23055560
42STK391.22722316
43PHKG11.22378868
44PHKG21.22378868
45PAK41.21762394
46RPS6KA61.20359122
47RIPK11.18806366
48PTK61.17736270
49FGFR21.17076719
50TNK21.14776534
51PDGFRA1.09789202
52TESK21.07880885
53CDC42BPA1.05257726
54WNK31.04850938
55TTN1.04443333
56FGFR41.03249941
57EPHB11.02210745
58CAMKK11.01849777
59EPHA40.96068894
60CSNK1G10.94217210
61CSNK1G30.92998410
62GRK60.92118291
63LMTK20.91961530
64LIMK10.91296301
65DDR20.88469604
66KDR0.86451103
67BRSK20.86379371
68MAP2K30.85741835
69PIK3CA0.85350759
70PASK0.85022346
71MAP2K40.84322275
72PDPK10.84306883
73SGK2230.84249813
74SGK4940.84249813
75MAP3K110.81121174
76PAK30.78147721
77NTRK30.77640054
78DAPK30.77519765
79IRAK20.76702276
80BMX0.76017640
81CDK190.75347471
82SIK30.75235114
83MAPK120.73801265
84NME10.70629196
85TGFBR10.70366618
86MAPK110.68484331
87CSNK1A1L0.67702028
88MAPK70.67291989
89BUB10.66064332
90INSRR0.65413037
91PIM20.64625827
92PRKD10.64108987
93CAMK1D0.61901520
94AKT20.61846975
95HIPK20.60862819
96CAMK10.60076769
97MAP3K30.59192218
98TNIK0.58855596
99RPS6KB20.58799964
100BTK0.58793829
101CSF1R0.58037765
102TESK10.56026405
103CAMK2D0.54263696
104MAPKAPK30.52918647
105PIK3CG0.52597107
106RET0.52284366
107STK380.51219065
108PRKAA10.51194316
109DAPK20.50789872
110MAP2K60.50455503
111CAMK40.50274206
112PRKD20.50128113
113PAK20.49757587
114TGFBR20.49639836
115NEK20.49436626
116MARK20.48460721
117ACVR1B0.47331839
118BRSK10.47191135
119EPHA30.47089034
120VRK10.46956793
121MARK10.45177765
122ARAF0.44869723
123MAP3K70.43968348
124KSR10.43564334
125KIT0.43057170
126MTOR0.42967061
127STK110.42638137
128MAPK40.42489456
129SGK30.41654671
130MAP4K10.40431563
131ZAP700.39239690
132MAP2K70.39023034
133NEK10.38624891
134DMPK0.37965673
135MAPK80.37860182
136CAMK2G0.37276335
137WNK10.37243488
138PTK20.36701871
139ROCK20.36684980
140TBK10.36357852
141IRAK10.36048066
142PDGFRB0.35568492
143PRKCZ0.35090766
144CSNK1G20.34201650
145RPS6KA10.32956416
146RPS6KA40.32922414
147PKN10.31799022
148ROCK10.29591613
149PRKCI0.28481778

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.65302865
2Sulfur metabolism_Homo sapiens_hsa009203.48466230
3Sulfur relay system_Homo sapiens_hsa041223.05090200
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.84588070
5Fatty acid degradation_Homo sapiens_hsa000712.69664271
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.55256814
7Propanoate metabolism_Homo sapiens_hsa006402.53121192
8Butanoate metabolism_Homo sapiens_hsa006502.51141940
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.39797481
10Ribosome_Homo sapiens_hsa030102.28199638
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27417054
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26038359
13Tryptophan metabolism_Homo sapiens_hsa003802.08566572
14Parkinsons disease_Homo sapiens_hsa050121.99588626
15Fatty acid metabolism_Homo sapiens_hsa012121.98627438
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.95984677
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91596435
18Folate biosynthesis_Homo sapiens_hsa007901.81815831
19Fat digestion and absorption_Homo sapiens_hsa049751.81358350
20Oxidative phosphorylation_Homo sapiens_hsa001901.78539255
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71707458
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67413193
23Axon guidance_Homo sapiens_hsa043601.66538333
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64658026
25Peroxisome_Homo sapiens_hsa041461.64441062
26Pyruvate metabolism_Homo sapiens_hsa006201.57914847
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57319196
28Protein export_Homo sapiens_hsa030601.56367732
29VEGF signaling pathway_Homo sapiens_hsa043701.53406976
30Carbon metabolism_Homo sapiens_hsa012001.49554967
31Fatty acid elongation_Homo sapiens_hsa000621.44776862
32Selenocompound metabolism_Homo sapiens_hsa004501.41246533
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40194705
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37960784
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33802988
36Choline metabolism in cancer_Homo sapiens_hsa052311.29661154
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.28761440
38mTOR signaling pathway_Homo sapiens_hsa041501.26043557
39Histidine metabolism_Homo sapiens_hsa003401.25492145
40Alzheimers disease_Homo sapiens_hsa050101.24118662
41PPAR signaling pathway_Homo sapiens_hsa033201.23941612
42beta-Alanine metabolism_Homo sapiens_hsa004101.22885370
43N-Glycan biosynthesis_Homo sapiens_hsa005101.20582298
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.17251154
45ErbB signaling pathway_Homo sapiens_hsa040121.16676290
46Dilated cardiomyopathy_Homo sapiens_hsa054141.15821263
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.15725197
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15483605
49Melanogenesis_Homo sapiens_hsa049161.14466411
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.14139485
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12996326
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12026610
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10011750
54Huntingtons disease_Homo sapiens_hsa050161.09308523
55Notch signaling pathway_Homo sapiens_hsa043301.07549812
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06629839
57Arginine and proline metabolism_Homo sapiens_hsa003301.05461814
58Cocaine addiction_Homo sapiens_hsa050301.04531449
59Tyrosine metabolism_Homo sapiens_hsa003501.02883780
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02598266
61Endometrial cancer_Homo sapiens_hsa052131.01432588
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.00806802
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00465212
64Acute myeloid leukemia_Homo sapiens_hsa052210.98063386
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97402784
66Glutathione metabolism_Homo sapiens_hsa004800.93187017
67Systemic lupus erythematosus_Homo sapiens_hsa053220.92635376
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90798517
69Chemical carcinogenesis_Homo sapiens_hsa052040.90479893
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89176499
71Biosynthesis of amino acids_Homo sapiens_hsa012300.88645956
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88541410
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88062622
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85633594
75Lysine degradation_Homo sapiens_hsa003100.84447381
76Nitrogen metabolism_Homo sapiens_hsa009100.84419780
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84230687
78Cardiac muscle contraction_Homo sapiens_hsa042600.83406640
79Cholinergic synapse_Homo sapiens_hsa047250.83163127
80Hippo signaling pathway_Homo sapiens_hsa043900.81536508
81GnRH signaling pathway_Homo sapiens_hsa049120.81105235
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81043973
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80941944
84Non-small cell lung cancer_Homo sapiens_hsa052230.80193026
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.79264567
86Gap junction_Homo sapiens_hsa045400.78588679
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78488778
88Endocytosis_Homo sapiens_hsa041440.78011587
89Arginine biosynthesis_Homo sapiens_hsa002200.76975286
90Estrogen signaling pathway_Homo sapiens_hsa049150.75238798
91Caffeine metabolism_Homo sapiens_hsa002320.74422983
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74160107
93Insulin secretion_Homo sapiens_hsa049110.74003012
94Ovarian steroidogenesis_Homo sapiens_hsa049130.73429583
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73409475
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73309218
97Starch and sucrose metabolism_Homo sapiens_hsa005000.73107611
98Bile secretion_Homo sapiens_hsa049760.72188446
99Basal cell carcinoma_Homo sapiens_hsa052170.71336004
100Steroid biosynthesis_Homo sapiens_hsa001000.70582728
101Rap1 signaling pathway_Homo sapiens_hsa040150.68338272
102Inositol phosphate metabolism_Homo sapiens_hsa005620.67904321
103Phenylalanine metabolism_Homo sapiens_hsa003600.67736249
104ECM-receptor interaction_Homo sapiens_hsa045120.67611541
105Metabolic pathways_Homo sapiens_hsa011000.67127308
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.66115096
107Morphine addiction_Homo sapiens_hsa050320.65826073
108Prolactin signaling pathway_Homo sapiens_hsa049170.65795991
109Glutamatergic synapse_Homo sapiens_hsa047240.65479434
110Bladder cancer_Homo sapiens_hsa052190.64994720
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64442009
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63816141
113MAPK signaling pathway_Homo sapiens_hsa040100.62830776
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62700563
115Pentose phosphate pathway_Homo sapiens_hsa000300.62577775
116Glioma_Homo sapiens_hsa052140.62455345
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60697962
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59902986
119cAMP signaling pathway_Homo sapiens_hsa040240.59846037
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59560893
121Gastric acid secretion_Homo sapiens_hsa049710.58811115
122Retinol metabolism_Homo sapiens_hsa008300.58596772
123Glucagon signaling pathway_Homo sapiens_hsa049220.57874153
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57555414
125Circadian entrainment_Homo sapiens_hsa047130.54985277
126Oxytocin signaling pathway_Homo sapiens_hsa049210.54669795
127Sphingolipid metabolism_Homo sapiens_hsa006000.53490018
128Synaptic vesicle cycle_Homo sapiens_hsa047210.53216458
129Glycerolipid metabolism_Homo sapiens_hsa005610.51861815
130Amphetamine addiction_Homo sapiens_hsa050310.51508350
131Ras signaling pathway_Homo sapiens_hsa040140.51491911
132ABC transporters_Homo sapiens_hsa020100.51326361
133Focal adhesion_Homo sapiens_hsa045100.49569612
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49205534
135Tight junction_Homo sapiens_hsa045300.47972942
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.47947989
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47482430
138Wnt signaling pathway_Homo sapiens_hsa043100.46288599
139Dopaminergic synapse_Homo sapiens_hsa047280.46208145
140Fructose and mannose metabolism_Homo sapiens_hsa000510.44826727
141Spliceosome_Homo sapiens_hsa030400.44438066
142Alcoholism_Homo sapiens_hsa050340.42194398
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41343154
144AMPK signaling pathway_Homo sapiens_hsa041520.41193461
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40740749
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39579270
147Base excision repair_Homo sapiens_hsa034100.39372073
148Hedgehog signaling pathway_Homo sapiens_hsa043400.37595294
149Protein digestion and absorption_Homo sapiens_hsa049740.37390676
150Thyroid cancer_Homo sapiens_hsa052160.35884105
151Other glycan degradation_Homo sapiens_hsa005110.35721658
152Insulin resistance_Homo sapiens_hsa049310.34642456
153Galactose metabolism_Homo sapiens_hsa000520.33907115
154Chronic myeloid leukemia_Homo sapiens_hsa052200.33411361
155Complement and coagulation cascades_Homo sapiens_hsa046100.30873827
156Linoleic acid metabolism_Homo sapiens_hsa005910.27355580
157Pyrimidine metabolism_Homo sapiens_hsa002400.24955309
158Insulin signaling pathway_Homo sapiens_hsa049100.22093883
159Glycosaminoglycan degradation_Homo sapiens_hsa005310.20534317
160Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20296411
161Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20145679
162Arachidonic acid metabolism_Homo sapiens_hsa005900.20025211
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.19738870
164Adipocytokine signaling pathway_Homo sapiens_hsa049200.18647649

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