WASH3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* Arp2/3 complex-mediated actin nucleation (GO:0034314)5.94482747
2positive regulation of gamma-delta T cell activation (GO:0046645)5.54008765
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.19781040
4negative regulation of cell killing (GO:0031342)5.19781040
5negative regulation of erythrocyte differentiation (GO:0045647)4.75875084
6* actin nucleation (GO:0045010)4.71388375
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.52887543
8antigen processing and presentation of endogenous antigen (GO:0019883)4.42618293
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40616549
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.26510864
11regulation of gamma-delta T cell activation (GO:0046643)4.20963761
12positive thymic T cell selection (GO:0045059)4.17146339
13response to muramyl dipeptide (GO:0032495)4.12516695
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05605727
15NIK/NF-kappaB signaling (GO:0038061)4.05202266
16regulation of gamma-delta T cell differentiation (GO:0045586)4.02015268
17positive regulation of B cell differentiation (GO:0045579)3.98080586
18thymic T cell selection (GO:0045061)3.88457999
19detection of bacterium (GO:0016045)3.87949030
20regulation of B cell receptor signaling pathway (GO:0050855)3.81579415
21response to peptidoglycan (GO:0032494)3.81350099
22negative thymic T cell selection (GO:0045060)3.68649955
23detection of other organism (GO:0098543)3.63708394
24negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.62784909
25neutrophil activation involved in immune response (GO:0002283)3.59621325
26negative T cell selection (GO:0043383)3.58052597
27T cell selection (GO:0045058)3.50189133
28mannose metabolic process (GO:0006013)3.44308997
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.39048353
30leukocyte aggregation (GO:0070486)3.37783841
31regulation of B cell differentiation (GO:0045577)3.34736851
32modulation by symbiont of host immune response (GO:0052553)3.33962665
33positive regulation by symbiont of host defense response (GO:0052509)3.33962665
34modulation by symbiont of host defense response (GO:0052031)3.33962665
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33962665
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33962665
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.33962665
38positive T cell selection (GO:0043368)3.31883996
39negative regulation of interleukin-12 production (GO:0032695)3.30718593
40immunoglobulin mediated immune response (GO:0016064)3.29930310
41germinal center formation (GO:0002467)3.28894543
42response to interleukin-15 (GO:0070672)3.28799577
43B cell receptor signaling pathway (GO:0050853)3.28325218
44tolerance induction (GO:0002507)3.26600647
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.18078110
46regulation of natural killer cell mediated immunity (GO:0002715)3.18078110
47neutrophil activation (GO:0042119)3.17519971
48cellular response to interleukin-15 (GO:0071350)3.16347499
49granulocyte activation (GO:0036230)3.11550553
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.10649841
51Peyers patch development (GO:0048541)3.10188536
52mucosal-associated lymphoid tissue development (GO:0048537)3.10188536
53negative regulation of innate immune response (GO:0045824)3.07328133
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06962870
55type I interferon signaling pathway (GO:0060337)3.05390166
56cellular response to type I interferon (GO:0071357)3.05390166
57response to type I interferon (GO:0034340)3.03916136
58positive regulation of granulocyte differentiation (GO:0030854)2.98252901
59negative regulation of leukocyte mediated immunity (GO:0002704)2.97140871
60regulation of mast cell degranulation (GO:0043304)2.95913513
61regulation of antigen processing and presentation (GO:0002577)2.95485166
62defense response to protozoan (GO:0042832)2.93480544
63positive regulation of antigen processing and presentation (GO:0002579)2.90219834
64regulation of granulocyte differentiation (GO:0030852)2.87800720
65regulation of T cell tolerance induction (GO:0002664)2.87712030
66regulation of interleukin-2 biosynthetic process (GO:0045076)2.87570994
67macrophage activation involved in immune response (GO:0002281)2.86396858
68regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84884990
69T cell migration (GO:0072678)2.84026335
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82869112
71negative regulation of T cell mediated immunity (GO:0002710)2.79354283
72respiratory burst (GO:0045730)2.78129535
73response to protozoan (GO:0001562)2.75784018
74detection of external biotic stimulus (GO:0098581)2.74053151
75regulation of regulatory T cell differentiation (GO:0045589)2.72032215
76regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70343170
77regulation of ARF GTPase activity (GO:0032312)2.67386727
78antigen receptor-mediated signaling pathway (GO:0050851)2.65895043
79N-acetylneuraminate metabolic process (GO:0006054)2.65378049
80regulation of leukocyte degranulation (GO:0043300)2.61333130
81negative regulation of granulocyte differentiation (GO:0030853)2.59656395
82regulation of tolerance induction (GO:0002643)2.59148328
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57661564
84regulation of T cell mediated cytotoxicity (GO:0001914)2.57275321
85myeloid cell activation involved in immune response (GO:0002275)2.55794748
86natural killer cell differentiation (GO:0001779)2.55716299
87regulation of interferon-beta biosynthetic process (GO:0045357)2.53680765
88lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53174244
89regulation of mast cell activation involved in immune response (GO:0033006)2.52843737
90modulation by virus of host process (GO:0019054)2.52753114
91T cell receptor signaling pathway (GO:0050852)2.51955283
92myeloid dendritic cell activation (GO:0001773)2.51946513
93regulation of monocyte differentiation (GO:0045655)2.51890372
94detection of biotic stimulus (GO:0009595)2.51615672
95leukocyte degranulation (GO:0043299)2.51538267
96* retrograde transport, endosome to Golgi (GO:0042147)2.50869486
97negative regulation of myeloid cell apoptotic process (GO:0033033)2.50840813
98myeloid dendritic cell differentiation (GO:0043011)2.50141166
99regulation of interleukin-2 production (GO:0032663)2.49828445
100regulation of leukocyte mediated cytotoxicity (GO:0001910)2.49605990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.22880249
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.06715171
3MYC_22102868_ChIP-Seq_BL_Human2.85383227
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50258564
5LXR_22292898_ChIP-Seq_THP-1_Human2.49894464
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.49043452
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42646666
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30809849
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29102988
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22736688
11MAF_26560356_Chip-Seq_TH1_Human2.22685189
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20517164
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18054956
14* MAF_26560356_Chip-Seq_TH2_Human2.12494985
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12102717
16UTX_26944678_Chip-Seq_JUKART_Human2.11036868
17KDM2B_26808549_Chip-Seq_DND41_Human2.09644217
18* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.09419912
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.04465823
20MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.03055910
21VDR_24763502_ChIP-Seq_THP-1_Human2.02602280
22TCF7_22412390_ChIP-Seq_EML_Mouse2.00250176
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98142982
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94158029
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94125159
26SCL_19346495_ChIP-Seq_HPC-7_Human1.92111437
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.88411510
28BCL6_27268052_Chip-Seq_Bcells_Human1.86853648
29P68_20966046_ChIP-Seq_HELA_Human1.81847066
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.75819307
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.74539813
32* SPI1_23127762_ChIP-Seq_K562_Human1.72578543
33BCOR_27268052_Chip-Seq_Bcells_Human1.68233667
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66147673
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65496399
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65386566
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64236623
38* SPI1_23547873_ChIP-Seq_NB4_Human1.64106361
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57218638
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.55266589
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54889651
42MYB_26560356_Chip-Seq_TH2_Human1.54313599
43NCOR1_26117541_ChIP-Seq_K562_Human1.54155045
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53039409
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49114280
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48680926
47RACK7_27058665_Chip-Seq_MCF-7_Human1.48617485
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.48217157
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44456962
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43202287
51SMC4_20622854_ChIP-Seq_HELA_Human1.43176611
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42391373
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.42036171
54RUNX_20019798_ChIP-Seq_JUKART_Human1.40185624
55* MYB_26560356_Chip-Seq_TH1_Human1.39638973
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39108909
57CIITA_25753668_ChIP-Seq_RAJI_Human1.36896687
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36520094
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.36122794
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.34858196
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33655263
62GATA1_19941826_ChIP-Seq_K562_Human1.32348035
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31897577
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30819964
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30579569
66CTCF_26484167_Chip-Seq_Bcells_Mouse1.30335004
67E2F1_20622854_ChIP-Seq_HELA_Human1.30000721
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29580765
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29295494
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27038901
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26604842
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26338594
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26335479
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25987307
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25940245
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25243028
77PHF8_20622854_ChIP-Seq_HELA_Human1.24950393
78SA1_27219007_Chip-Seq_Bcells_Human1.24483460
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23581999
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22600239
81KDM2B_26808549_Chip-Seq_K562_Human1.21824747
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21205630
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20811280
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19751242
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.19653703
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18451641
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16718376
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16273492
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15614301
90CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15503762
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15115806
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.14521525
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13822557
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13624157
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13586094
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13545886
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12867660
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12126744
99CREB1_26743006_Chip-Seq_LNCaP_Human1.08872233
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08768422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.12259518
2MP0005671_abnormal_response_to3.16005928
3MP0005058_abnormal_lysosome_morphology3.11869194
4MP0003724_increased_susceptibility_to2.96824953
5MP0003303_peritoneal_inflammation2.91931915
6MP0001835_abnormal_antigen_presentation2.90397354
7MP0005000_abnormal_immune_tolerance2.82140163
8MP0005025_abnormal_response_to2.71956225
9MP0005387_immune_system_phenotype2.69523876
10MP0001790_abnormal_immune_system2.69523876
11MP0001800_abnormal_humoral_immune2.68018725
12MP0009278_abnormal_bone_marrow2.67377910
13MP0003763_abnormal_thymus_physiology2.66232483
14MP0003172_abnormal_lysosome_physiology2.65865809
15MP0000685_abnormal_immune_system2.62528894
16MP0002419_abnormal_innate_immunity2.58104232
17MP0002723_abnormal_immune_serum2.54806874
18MP0009785_altered_susceptibility_to2.49994120
19MP0002420_abnormal_adaptive_immunity2.44465418
20MP0001819_abnormal_immune_cell2.42018142
21MP0002148_abnormal_hypersensitivity_rea2.38931966
22MP0002452_abnormal_antigen_presenting2.32091026
23MP0004947_skin_inflammation2.23393216
24MP0008260_abnormal_autophagy2.19632961
25MP0009333_abnormal_splenocyte_physiolog2.16577371
26MP0002398_abnormal_bone_marrow2.10280479
27MP0005464_abnormal_platelet_physiology2.01170038
28MP0002405_respiratory_system_inflammati1.97098779
29MP0010155_abnormal_intestine_physiology1.96791228
30MP0000716_abnormal_immune_system1.95122994
31MP0005397_hematopoietic_system_phenotyp1.93215099
32MP0001545_abnormal_hematopoietic_system1.93215099
33MP0006082_CNS_inflammation1.89560863
34MP0001873_stomach_inflammation1.82436374
35MP0001533_abnormal_skeleton_physiology1.81860956
36MP0005451_abnormal_body_composition1.71312342
37MP0002722_abnormal_immune_system1.69499590
38MP0000689_abnormal_spleen_morphology1.68296168
39MP0000465_gastrointestinal_hemorrhage1.68090011
40MP0000703_abnormal_thymus_morphology1.66845371
41MP0002429_abnormal_blood_cell1.64413225
42MP0003866_abnormal_defecation1.62965726
43MP0003806_abnormal_nucleotide_metabolis1.62224900
44MP0003300_gastrointestinal_ulcer1.62007277
45MP0001845_abnormal_inflammatory_respons1.59354368
46MP0003183_abnormal_peptide_metabolism1.53717340
47MP0003656_abnormal_erythrocyte_physiolo1.51644911
48MP0009840_abnormal_foam_cell1.45736120
49MP0000858_altered_metastatic_potential1.42559042
50MP0002933_joint_inflammation1.40509793
51MP0001853_heart_inflammation1.40101691
52MP0003191_abnormal_cellular_cholesterol1.35078041
53MP0009764_decreased_sensitivity_to1.33148628
54MP0008469_abnormal_protein_level1.32684718
55MP0004510_myositis1.30204896
56MP0005083_abnormal_biliary_tract1.28647041
57MP0004381_abnormal_hair_follicle1.25434698
58MP0000604_amyloidosis1.21102464
59MP0003329_amyloid_beta_deposits1.13423925
60MP0005310_abnormal_salivary_gland1.12360053
61MP0002998_abnormal_bone_remodeling1.11662218
62MP0002132_abnormal_respiratory_system1.04414873
63MP0002396_abnormal_hematopoietic_system1.03734215
64MP0004858_abnormal_nervous_system0.95366688
65MP0003075_altered_response_to0.94919848
66MP0005390_skeleton_phenotype0.88154110
67MP0009765_abnormal_xenobiotic_induced0.85531511
68MP0001663_abnormal_digestive_system0.84533352
69MP0002166_altered_tumor_susceptibility0.83066451
70MP0000343_altered_response_to0.82852535
71MP0002138_abnormal_hepatobiliary_system0.81736608
72MP0009763_increased_sensitivity_to0.79713638
73MP0005075_abnormal_melanosome_morpholog0.79538665
74MP0000678_abnormal_parathyroid_gland0.78614263
75MP0001986_abnormal_taste_sensitivity0.78174173
76MP0003453_abnormal_keratinocyte_physiol0.76763793
77MP0000490_abnormal_crypts_of0.76460665
78MP0002009_preneoplasia0.76288976
79MP0003690_abnormal_glial_cell0.75745242
80MP0002019_abnormal_tumor_incidence0.75404661
81MP0003795_abnormal_bone_structure0.73899773
82MP0008874_decreased_physiological_sensi0.73777641
83MP0003828_pulmonary_edema0.72599782
84MP0005535_abnormal_body_temperature0.71761946
85MP0008995_early_reproductive_senescence0.71725731
86MP0001851_eye_inflammation0.70589093
87MP0000681_abnormal_thyroid_gland0.68805099
88MP0005166_decreased_susceptibility_to0.67807035
89MP0000015_abnormal_ear_pigmentation0.67749346
90MP0004808_abnormal_hematopoietic_stem0.63620983
91MP0001849_ear_inflammation0.62864859
92MP0005076_abnormal_cell_differentiation0.61669605
93MP0009931_abnormal_skin_appearance0.55233970
94MP0000609_abnormal_liver_physiology0.54282844
95MP0003879_abnormal_hair_cell0.54248121
96MP0003448_altered_tumor_morphology0.53521054
97MP0005381_digestive/alimentary_phenotyp0.52178405
98MP0003045_fibrosis0.51193117
99MP0000249_abnormal_blood_vessel0.50932897
100MP0001348_abnormal_lacrimal_gland0.50853982

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.83078581
2Obstructive lung disease (HP:0006536)4.07339047
3Chronic obstructive pulmonary disease (HP:0006510)4.07339047
4Myositis (HP:0100614)4.06001295
5Recurrent bacterial skin infections (HP:0005406)4.04043149
6Abnormality of macrophages (HP:0004311)4.03615677
7Recurrent abscess formation (HP:0002722)4.01180384
8Elevated erythrocyte sedimentation rate (HP:0003565)3.99616851
9Mediastinal lymphadenopathy (HP:0100721)3.72919519
10Stomatitis (HP:0010280)3.54978978
11Meningitis (HP:0001287)3.42019065
12Recurrent fungal infections (HP:0002841)3.33076251
13Increased IgE level (HP:0003212)3.25087785
14Gastrointestinal infarctions (HP:0005244)3.24203357
15Orchitis (HP:0100796)3.22363101
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.13118796
17Pustule (HP:0200039)3.04320911
18Gastrointestinal inflammation (HP:0004386)3.02583664
19Panhypogammaglobulinemia (HP:0003139)3.02106919
20Hypertensive crisis (HP:0100735)2.99373045
21Colitis (HP:0002583)2.95373764
22Prolonged bleeding time (HP:0003010)2.94768951
23Dysostosis multiplex (HP:0000943)2.94556325
24Vasculitis (HP:0002633)2.92674179
25Granulocytopenia (HP:0001913)2.90338674
26Inflammation of the large intestine (HP:0002037)2.89608982
27Retrobulbar optic neuritis (HP:0100654)2.86480018
28Optic neuritis (HP:0100653)2.86480018
29Increased IgM level (HP:0003496)2.85801048
30Recurrent skin infections (HP:0001581)2.85092365
31Recurrent viral infections (HP:0004429)2.75235596
32Encephalitis (HP:0002383)2.74462098
33Agammaglobulinemia (HP:0004432)2.74127150
34Purpura (HP:0000979)2.70376039
35Chronic mucocutaneous candidiasis (HP:0002728)2.69099332
36Recurrent cutaneous fungal infections (HP:0011370)2.69099332
37Increased serum ferritin (HP:0003281)2.67832885
38Seborrheic dermatitis (HP:0001051)2.63346842
39Petechiae (HP:0000967)2.59842345
40Recurrent gram-negative bacterial infections (HP:0005420)2.59691160
41Reticulocytosis (HP:0001923)2.58435969
42Cellulitis (HP:0100658)2.57719090
43Severe combined immunodeficiency (HP:0004430)2.55614562
44Abnormal gallbladder physiology (HP:0012438)2.51033759
45Cholecystitis (HP:0001082)2.51033759
46Abnormality of liposaccharide metabolism (HP:0010968)2.47853388
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.47853388
48Abnormality of glycolipid metabolism (HP:0010969)2.47853388
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.47834367
50Pulmonary infiltrates (HP:0002113)2.44277208
51Chest pain (HP:0100749)2.43578901
52Gastrointestinal stroma tumor (HP:0100723)2.41710759
53Epistaxis (HP:0000421)2.40023579
54Increased cerebral lipofuscin (HP:0011813)2.39464404
55Hepatosplenomegaly (HP:0001433)2.37610156
56Abnormality of T cells (HP:0002843)2.37139001
57Abnormality of lateral ventricle (HP:0030047)2.36851333
58IgG deficiency (HP:0004315)2.35733065
59Gingivitis (HP:0000230)2.35310341
60Autoimmune hemolytic anemia (HP:0001890)2.32030503
61Hemorrhage of the eye (HP:0011885)2.31712966
62Autoimmune thrombocytopenia (HP:0001973)2.31624868
63T lymphocytopenia (HP:0005403)2.31160801
64Hypochromic anemia (HP:0001931)2.30892404
65Hypergammaglobulinemia (HP:0010702)2.28502597
66Abnormality of iron homeostasis (HP:0011031)2.27709109
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24208834
68Abnormality of polysaccharide metabolism (HP:0011012)2.24208834
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24208834
70Myopathic facies (HP:0002058)2.23637444
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23223356
72Leukocytosis (HP:0001974)2.20661712
73Combined immunodeficiency (HP:0005387)2.18851690
74J-shaped sella turcica (HP:0002680)2.18046527
75Lymphopenia (HP:0001888)2.16928066
76Abnormality of T cell physiology (HP:0011840)2.16140457
77Loss of speech (HP:0002371)2.14918943
78Hemoptysis (HP:0002105)2.14878409
79Abnormality of T cell number (HP:0011839)2.10700198
80Urticaria (HP:0001025)2.08865998
81Keratoconjunctivitis sicca (HP:0001097)2.07643154
82Obstructive sleep apnea (HP:0002870)2.07360746
83Fatigue (HP:0012378)2.06962516
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.06694806
85Spontaneous hematomas (HP:0007420)2.05767573
86Urinary glycosaminoglycan excretion (HP:0003541)2.05461261
87Mucopolysacchariduria (HP:0008155)2.05461261
88Systemic lupus erythematosus (HP:0002725)2.04008485
89Restrictive lung disease (HP:0002091)1.99251313
90Acute hepatic failure (HP:0006554)1.99082451
91Abnormality of cells of the lymphoid lineage (HP:0012140)1.96998588
92Premature loss of primary teeth (HP:0006323)1.96328266
93Emphysema (HP:0002097)1.95774208
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91073751
95Episodic fever (HP:0001954)1.90797351
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90369683
97Easy fatigability (HP:0003388)1.90324938
98Truncus arteriosus (HP:0001660)1.90014523
99Eosinophilia (HP:0001880)1.88395864
100Sepsis (HP:0100806)1.87888880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.71046811
2TAOK33.39695254
3RIPK43.37002265
4ERN12.99683327
5TXK2.60069149
6TNK22.51537708
7TRIB32.36451082
8GRK62.22377962
9PRPF4B2.20783147
10TBK12.08901588
11MAP2K32.04426689
12MAP3K112.03888839
13FES2.00457287
14TESK21.92148386
15MAP3K141.84584019
16SIK11.75384558
17ZAP701.70448794
18SIK21.67905689
19TYK21.67904931
20MAP3K131.66237922
21IRAK41.63987251
22BLK1.60018322
23BTK1.58083403
24SIK31.54956068
25NME21.51015911
26SYK1.46217563
27IKBKE1.44345533
28JAK31.43761295
29KDR1.41993574
30CSK1.39396122
31IRAK31.37896800
32TAOK11.33448043
33IKBKB1.31995105
34TAOK21.27937655
35EPHB11.19942365
36MAP2K21.15490768
37BCKDK1.15102832
38MARK21.12990186
39ITK1.07938420
40MAP3K71.07085215
41HCK1.04961738
42LYN1.02732113
43LCK1.01562662
44ICK1.01118701
45CSF1R1.00974499
46PRKD20.97051583
47MAPK120.96206424
48MAP3K30.93842935
49MAP3K10.93081162
50MAP2K60.90799477
51JAK20.90396209
52CDC42BPA0.86854302
53SMG10.84302766
54MAPK150.84079099
55KSR20.83516931
56MATK0.82550176
57BMX0.79495093
58CAMKK10.78830973
59PTK60.75212734
60TESK10.74940304
61FGR0.74635073
62MAPK110.74338989
63PKN20.72474371
64PIM20.71586584
65DYRK1B0.70316841
66RPS6KC10.69999710
67RPS6KL10.69999710
68MAPK70.69261757
69KIT0.67818487
70PDK10.67603445
71MAP3K60.64632146
72HIPK20.64489065
73PDPK10.63592676
74FGFR40.61346131
75CDK40.61283025
76TEC0.60393273
77JAK10.58538686
78RIPK10.57202886
79MARK30.56204327
80RPS6KA60.56198967
81EEF2K0.55169143
82FYN0.54733436
83RPS6KA20.54536004
84CHUK0.49281756
85PIM10.48702088
86MAPKAPK30.47758551
87LRRK20.46456744
88PRKCQ0.46043139
89MAPK40.45984858
90MAPK30.42353853
91BMPR20.40377123
92MAP3K100.38873811
93TYRO30.36800753
94CDK120.35995519
95MAPKAPK20.35687796
96GRK70.33432203
97RET0.32254430
98PAK60.31923458
99DAPK10.26309488
100RPS6KA10.25676821

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.27590014
2Other glycan degradation_Homo sapiens_hsa005113.11640394
3Osteoclast differentiation_Homo sapiens_hsa043802.64127797
4B cell receptor signaling pathway_Homo sapiens_hsa046622.37102108
5Leishmaniasis_Homo sapiens_hsa051402.31970145
6Allograft rejection_Homo sapiens_hsa053302.24136377
7Graft-versus-host disease_Homo sapiens_hsa053322.16952170
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.10844508
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10069439
10Autoimmune thyroid disease_Homo sapiens_hsa053202.09848705
11Acute myeloid leukemia_Homo sapiens_hsa052212.09402700
12T cell receptor signaling pathway_Homo sapiens_hsa046602.04823411
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00337991
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91479418
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.88838925
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83507796
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76922500
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.73170927
19Staphylococcus aureus infection_Homo sapiens_hsa051501.72326240
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.67623836
21Hematopoietic cell lineage_Homo sapiens_hsa046401.64086136
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62242925
23Antigen processing and presentation_Homo sapiens_hsa046121.60552534
24Type I diabetes mellitus_Homo sapiens_hsa049401.57642988
25Tuberculosis_Homo sapiens_hsa051521.57525780
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52298208
27TNF signaling pathway_Homo sapiens_hsa046681.46402430
28Shigellosis_Homo sapiens_hsa051311.46346378
29Measles_Homo sapiens_hsa051621.43776376
30Herpes simplex infection_Homo sapiens_hsa051681.43227231
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35466341
32VEGF signaling pathway_Homo sapiens_hsa043701.32871819
33Rheumatoid arthritis_Homo sapiens_hsa053231.32647005
34Toxoplasmosis_Homo sapiens_hsa051451.32528003
35Lysosome_Homo sapiens_hsa041421.32341441
36Salmonella infection_Homo sapiens_hsa051321.31938776
37Asthma_Homo sapiens_hsa053101.31889419
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30334033
39Chemokine signaling pathway_Homo sapiens_hsa040621.28582388
40Influenza A_Homo sapiens_hsa051641.27400474
41Malaria_Homo sapiens_hsa051441.24953131
42Notch signaling pathway_Homo sapiens_hsa043301.21418782
43Viral myocarditis_Homo sapiens_hsa054161.14862498
44Pertussis_Homo sapiens_hsa051331.10606342
45Non-small cell lung cancer_Homo sapiens_hsa052231.09776992
46Fructose and mannose metabolism_Homo sapiens_hsa000511.07759854
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.07519923
48Hepatitis B_Homo sapiens_hsa051611.04190629
49Apoptosis_Homo sapiens_hsa042101.03544927
50Chronic myeloid leukemia_Homo sapiens_hsa052201.03066626
51Hepatitis C_Homo sapiens_hsa051600.99135878
52Endocytosis_Homo sapiens_hsa041440.94422324
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.94200629
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91614601
55Epstein-Barr virus infection_Homo sapiens_hsa051690.91557490
56Sulfur relay system_Homo sapiens_hsa041220.90781863
57Phagosome_Homo sapiens_hsa041450.88932094
58Pancreatic cancer_Homo sapiens_hsa052120.80278312
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80211084
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.80065001
61Legionellosis_Homo sapiens_hsa051340.79691040
62Platelet activation_Homo sapiens_hsa046110.79512754
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78046807
64mTOR signaling pathway_Homo sapiens_hsa041500.78037335
65HTLV-I infection_Homo sapiens_hsa051660.72777992
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.71873251
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.71482664
68Prolactin signaling pathway_Homo sapiens_hsa049170.71180512
69Collecting duct acid secretion_Homo sapiens_hsa049660.70468310
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.70467805
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.68663663
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67364293
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66798276
74Choline metabolism in cancer_Homo sapiens_hsa052310.66383874
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59942031
76African trypanosomiasis_Homo sapiens_hsa051430.59658426
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59250582
78Prion diseases_Homo sapiens_hsa050200.58669932
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58262039
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.58022804
81GnRH signaling pathway_Homo sapiens_hsa049120.57620608
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53466759
83Viral carcinogenesis_Homo sapiens_hsa052030.52735927
84Regulation of autophagy_Homo sapiens_hsa041400.52733314
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52400621
86Pentose phosphate pathway_Homo sapiens_hsa000300.50863919
87Bladder cancer_Homo sapiens_hsa052190.47186257
88MAPK signaling pathway_Homo sapiens_hsa040100.46229909
89Synaptic vesicle cycle_Homo sapiens_hsa047210.45796704
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45471811
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44774603
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44051028
93Type II diabetes mellitus_Homo sapiens_hsa049300.43707796
94Insulin signaling pathway_Homo sapiens_hsa049100.41408109
95Insulin resistance_Homo sapiens_hsa049310.40403531
96Inositol phosphate metabolism_Homo sapiens_hsa005620.39596426
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39316372
98HIF-1 signaling pathway_Homo sapiens_hsa040660.37632557
99ErbB signaling pathway_Homo sapiens_hsa040120.36207659
100Renal cell carcinoma_Homo sapiens_hsa052110.35615549

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