WAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.49392148
2detection of other organism (GO:0098543)5.00970343
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.96594471
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.96594471
5detection of bacterium (GO:0016045)4.92179795
6regulation of B cell receptor signaling pathway (GO:0050855)4.79118058
7antigen processing and presentation of endogenous antigen (GO:0019883)4.65225539
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.62657902
9negative regulation of lymphocyte mediated immunity (GO:0002707)4.24195340
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.21116104
11detection of external biotic stimulus (GO:0098581)4.09954612
12leukocyte aggregation (GO:0070486)4.09669037
13positive regulation of B cell differentiation (GO:0045579)4.03187463
14positive regulation by symbiont of host defense response (GO:0052509)3.88257379
15modulation by symbiont of host defense response (GO:0052031)3.88257379
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88257379
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88257379
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.88257379
19modulation by symbiont of host immune response (GO:0052553)3.88257379
20regulation of gamma-delta T cell differentiation (GO:0045586)3.88167719
21negative regulation of phagocytosis (GO:0050765)3.86883038
22B cell receptor signaling pathway (GO:0050853)3.86844694
23regulation of B cell differentiation (GO:0045577)3.84584914
24negative regulation of leukocyte mediated immunity (GO:0002704)3.83761548
25regulation of gamma-delta T cell activation (GO:0046643)3.83723065
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.81682732
27negative regulation of T cell mediated immunity (GO:0002710)3.74832668
28T cell migration (GO:0072678)3.73067029
29negative regulation of cell killing (GO:0031342)3.67076379
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67076379
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.66906361
32detection of molecule of bacterial origin (GO:0032490)3.63319325
33detection of biotic stimulus (GO:0009595)3.61908565
34leukocyte migration involved in inflammatory response (GO:0002523)3.60754577
35neutrophil activation involved in immune response (GO:0002283)3.58905489
36immunoglobulin mediated immune response (GO:0016064)3.56626738
37negative regulation of erythrocyte differentiation (GO:0045647)3.53352015
38interferon-gamma production (GO:0032609)3.52675032
39negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.51632201
40regulation of T cell tolerance induction (GO:0002664)3.47296284
41respiratory burst (GO:0045730)3.47009864
42response to host (GO:0075136)3.45601272
43microglial cell activation (GO:0001774)3.45029869
44regulation of mast cell activation involved in immune response (GO:0033006)3.44772085
45regulation of myeloid leukocyte mediated immunity (GO:0002886)3.44394896
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43244894
47response to peptidoglycan (GO:0032494)3.39085033
48tolerance induction (GO:0002507)3.36891981
49cellular extravasation (GO:0045123)3.36442374
50mature B cell differentiation (GO:0002335)3.34484172
51positive thymic T cell selection (GO:0045059)3.33589440
52regulation of leukocyte degranulation (GO:0043300)3.31889036
53regulation of tolerance induction (GO:0002643)3.31471776
54mast cell activation (GO:0045576)3.30994272
55neutrophil mediated immunity (GO:0002446)3.30947516
56macrophage activation (GO:0042116)3.29336051
57negative T cell selection (GO:0043383)3.29262145
58neutrophil activation (GO:0042119)3.29205408
59response to interleukin-15 (GO:0070672)3.27581075
60negative thymic T cell selection (GO:0045060)3.23697032
61defense response to protozoan (GO:0042832)3.20520772
62ribosomal small subunit assembly (GO:0000028)3.19032560
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18208889
64myeloid dendritic cell activation (GO:0001773)3.17575285
65T cell homeostasis (GO:0043029)3.16963115
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16219309
67response to protozoan (GO:0001562)3.15607739
68production of molecular mediator involved in inflammatory response (GO:0002532)3.14560911
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.14558084
70regulation of interleukin-12 biosynthetic process (GO:0045075)3.11904612
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.11732539
72regulation of natural killer cell mediated immunity (GO:0002715)3.11732539
73regulation of interferon-beta biosynthetic process (GO:0045357)3.09125103
74cellular response to interleukin-15 (GO:0071350)3.08945094
75positive regulation of antigen processing and presentation (GO:0002579)3.05693292
76granulocyte activation (GO:0036230)3.04875940
77negative regulation of cytokine production involved in immune response (GO:0002719)3.04196200
78regulation of T cell mediated cytotoxicity (GO:0001914)3.03817491
79negative regulation of innate immune response (GO:0045824)3.02626070
80positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02516547
81antigen processing and presentation via MHC class Ib (GO:0002475)3.01580924
82negative regulation of interleukin-12 production (GO:0032695)3.00968922
83negative regulation of interleukin-6 production (GO:0032715)2.99699793
84mature B cell differentiation involved in immune response (GO:0002313)2.97513768
85regulation of T-helper 2 cell differentiation (GO:0045628)2.95704682
86lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94478333
87positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92954652
88negative regulation of type 2 immune response (GO:0002829)2.92443298
89activated T cell proliferation (GO:0050798)2.92299521
90lymphocyte homeostasis (GO:0002260)2.91870582
91response to type I interferon (GO:0034340)2.88596973
92B cell mediated immunity (GO:0019724)2.88405377
93myeloid cell activation involved in immune response (GO:0002275)2.84809289
94myeloid dendritic cell differentiation (GO:0043011)2.84633868
95cellular response to type I interferon (GO:0071357)2.84501031
96type I interferon signaling pathway (GO:0060337)2.84501031
97positive regulation of isotype switching (GO:0045830)2.83874033
98positive regulation of granulocyte differentiation (GO:0030854)2.83637523
99positive T cell selection (GO:0043368)2.82341760
100* antigen receptor-mediated signaling pathway (GO:0050851)2.81679071
101regulation of mast cell activation (GO:0033003)2.81559309
102megakaryocyte development (GO:0035855)2.80231961
103positive regulation of interferon-alpha production (GO:0032727)2.76402023
104regulation of antigen processing and presentation (GO:0002577)2.75897266
105response to muramyl dipeptide (GO:0032495)2.75866925
106regulation of alpha-beta T cell proliferation (GO:0046640)2.75849936
107mast cell activation involved in immune response (GO:0002279)2.75438553
108mast cell degranulation (GO:0043303)2.75438553
109regulation of T cell receptor signaling pathway (GO:0050856)2.74890695
110response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74784958
111response to host immune response (GO:0052572)2.74784958
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.74608768
113regulation of mast cell degranulation (GO:0043304)2.74384649
114interferon-gamma-mediated signaling pathway (GO:0060333)2.73791408
115negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.73615122
116cellular response to zinc ion (GO:0071294)2.73376725
117positive regulation of macrophage differentiation (GO:0045651)2.73051996
118leukocyte cell-cell adhesion (GO:0007159)2.72099223
119thymic T cell selection (GO:0045061)2.71667269
120T cell selection (GO:0045058)2.71369608
121definitive hemopoiesis (GO:0060216)2.70399924
122B cell homeostasis (GO:0001782)2.68029940
123positive regulation of mast cell activation (GO:0033005)2.66906999
124leukocyte degranulation (GO:0043299)2.66807818
125regulation of interferon-alpha production (GO:0032647)2.66767826
126NIK/NF-kappaB signaling (GO:0038061)2.66741311
127lymph node development (GO:0048535)2.64464233
128germinal center formation (GO:0002467)2.63014573
129macrophage activation involved in immune response (GO:0002281)2.62002298
130leukocyte homeostasis (GO:0001776)2.59229718
131actin nucleation (GO:0045010)2.59096165
132natural killer cell activation (GO:0030101)2.58937810
133positive regulation of interleukin-2 production (GO:0032743)2.57754880
134response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55420277
135response to host defenses (GO:0052200)2.55420277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.67885871
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.52138495
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.92459320
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88189610
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.72158071
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.67612147
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.65343959
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.64958480
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.20486327
10SCL_19346495_ChIP-Seq_HPC-7_Human3.12185772
11MYC_22102868_ChIP-Seq_BL_Human2.96236969
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.79965417
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78224014
14VDR_21846776_ChIP-Seq_THP-1_Human2.76511030
15* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.75800645
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64951068
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57814706
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56129627
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54826273
20SPI1_23547873_ChIP-Seq_NB4_Human2.54428871
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.53292140
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49676301
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46881448
24MYB_26560356_Chip-Seq_TH2_Human2.45763647
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33685559
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32111885
27MAF_26560356_Chip-Seq_TH1_Human2.26046061
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23009217
29MYB_26560356_Chip-Seq_TH1_Human2.20468104
30RUNX_20019798_ChIP-Seq_JUKART_Human2.20125289
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10245500
32VDR_24763502_ChIP-Seq_THP-1_Human2.10187196
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.09948891
34UTX_26944678_Chip-Seq_JUKART_Human2.00515140
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98028375
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96496766
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.96073930
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91738432
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.91557041
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91427025
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.89295890
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76591307
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71609599
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69394472
45SPI1_23127762_ChIP-Seq_K562_Human1.63900032
46TCF7_22412390_ChIP-Seq_EML_Mouse1.63182058
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62405600
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61946873
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59099588
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59067483
51CIITA_25753668_ChIP-Seq_RAJI_Human1.56666088
52VDR_24787735_ChIP-Seq_THP-1_Human1.54770875
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52154702
54MAF_26560356_Chip-Seq_TH2_Human1.50252378
55LXR_22292898_ChIP-Seq_THP-1_Human1.49838811
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49033547
57GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.47273887
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46315380
59VDR_23849224_ChIP-Seq_CD4+_Human1.40963932
60PU_27001747_Chip-Seq_BMDM_Mouse1.39235480
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38380136
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38161518
63GATA3_27048872_Chip-Seq_THYMUS_Human1.32989165
64FOXP3_21729870_ChIP-Seq_TREG_Human1.31290713
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30414601
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26419920
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25017201
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.24679878
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23165582
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22746331
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22524088
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22479121
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21923161
74* BCL6_27268052_Chip-Seq_Bcells_Human1.21368906
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19262125
76* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19035199
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18857251
78BCOR_27268052_Chip-Seq_Bcells_Human1.16677662
79GATA1_19941826_ChIP-Seq_K562_Human1.16527341
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16445077
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15627176
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14009334
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12883989
84GATA1_22025678_ChIP-Seq_K562_Human1.10003671
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09212753
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.08652192
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.08635817
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.07690405
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07676773
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.06601123
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04477881
92EST1_17652178_ChIP-ChIP_JURKAT_Human1.03870145
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03702351
94* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03563115
95* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03106234
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03059291
97NCOR1_26117541_ChIP-Seq_K562_Human1.00900910
98ELK1_19687146_ChIP-ChIP_HELA_Human1.00521023
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99927008
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.99080543
101KDM2B_26808549_Chip-Seq_DND41_Human0.99046829
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98661972
103GATA3_26560356_Chip-Seq_TH2_Human0.98268725
104GABP_17652178_ChIP-ChIP_JURKAT_Human0.97291420
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96255304
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95446695
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94138452
108TP63_19390658_ChIP-ChIP_HaCaT_Human0.94032817
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92834939
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.91738778
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91652311
112SPI1_20517297_ChIP-Seq_HL60_Human0.91602852
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89571096
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87686647
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85747394
116* ELK3_25401928_ChIP-Seq_HUVEC_Human0.84805538
117GATA2_19941826_ChIP-Seq_K562_Human0.84601792
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84527772
119ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84283800
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84192405
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83512054
122TFEB_21752829_ChIP-Seq_HELA_Human0.83369734
123XRN2_22483619_ChIP-Seq_HELA_Human0.80034858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.02224549
2MP0005671_abnormal_response_to3.32497925
3MP0001800_abnormal_humoral_immune3.20577790
4MP0000685_abnormal_immune_system3.16385599
5MP0005387_immune_system_phenotype3.09610057
6MP0001790_abnormal_immune_system3.09610057
7MP0003436_decreased_susceptibility_to3.09505024
8MP0009785_altered_susceptibility_to2.95139760
9* MP0005000_abnormal_immune_tolerance2.89432238
10* MP0002452_abnormal_antigen_presenting2.86602712
11MP0002396_abnormal_hematopoietic_system2.80358578
12* MP0003763_abnormal_thymus_physiology2.77287483
13MP0003303_peritoneal_inflammation2.75823861
14* MP0002723_abnormal_immune_serum2.72520153
15* MP0002420_abnormal_adaptive_immunity2.72080770
16* MP0001819_abnormal_immune_cell2.69158506
17MP0005025_abnormal_response_to2.68011076
18* MP0002419_abnormal_innate_immunity2.60453965
19* MP0002398_abnormal_bone_marrow2.55921203
20MP0002148_abnormal_hypersensitivity_rea2.55838406
21MP0005464_abnormal_platelet_physiology2.36916799
22* MP0000716_abnormal_immune_system2.29936029
23MP0002405_respiratory_system_inflammati2.21657116
24* MP0000689_abnormal_spleen_morphology2.15630450
25MP0009333_abnormal_splenocyte_physiolog2.13472366
26MP0006082_CNS_inflammation2.09021835
27* MP0002722_abnormal_immune_system2.07630607
28MP0004808_abnormal_hematopoietic_stem2.06658297
29MP0003724_increased_susceptibility_to2.03515022
30MP0002166_altered_tumor_susceptibility2.00197240
31* MP0002429_abnormal_blood_cell1.95441503
32MP0005174_abnormal_tail_pigmentation1.93956672
33MP0003300_gastrointestinal_ulcer1.92435111
34MP0005397_hematopoietic_system_phenotyp1.90462748
35MP0001545_abnormal_hematopoietic_system1.90462748
36MP0000465_gastrointestinal_hemorrhage1.89596587
37MP0001853_heart_inflammation1.87139781
38MP0009278_abnormal_bone_marrow1.85844332
39MP0001873_stomach_inflammation1.85806396
40* MP0010155_abnormal_intestine_physiology1.84250584
41* MP0000703_abnormal_thymus_morphology1.79895065
42* MP0001845_abnormal_inflammatory_respons1.74794368
43MP0002006_tumorigenesis1.73693632
44MP0008260_abnormal_autophagy1.64686307
45MP0003866_abnormal_defecation1.54402702
46MP0005310_abnormal_salivary_gland1.52289316
47* MP0000490_abnormal_crypts_of1.48707136
48MP0004510_myositis1.48194950
49MP0008057_abnormal_DNA_replication1.45795157
50MP0000015_abnormal_ear_pigmentation1.43520152
51MP0004947_skin_inflammation1.41995520
52MP0005075_abnormal_melanosome_morpholog1.41875162
53MP0001533_abnormal_skeleton_physiology1.40592125
54MP0003693_abnormal_embryo_hatching1.35859356
55MP0002933_joint_inflammation1.32958327
56MP0005451_abnormal_body_composition1.32135315
57MP0010094_abnormal_chromosome_stability1.31428145
58MP0000858_altered_metastatic_potential1.29810406
59MP0008469_abnormal_protein_level1.29303105
60MP0005058_abnormal_lysosome_morphology1.28450614
61MP0003172_abnormal_lysosome_physiology1.27984321
62MP0008058_abnormal_DNA_repair1.19801627
63MP0002095_abnormal_skin_pigmentation1.17721520
64MP0003448_altered_tumor_morphology1.17334827
65MP0002132_abnormal_respiratory_system1.10972019
66MP0004883_abnormal_blood_vessel1.10651711
67MP0002019_abnormal_tumor_incidence1.10413575
68MP0003077_abnormal_cell_cycle1.08235891
69MP0003111_abnormal_nucleus_morphology1.07573453
70MP0003183_abnormal_peptide_metabolism1.06360628
71MP0010307_abnormal_tumor_latency1.05286073
72MP0000343_altered_response_to0.97583832
73MP0003690_abnormal_glial_cell0.95321839
74MP0009764_decreased_sensitivity_to0.94336067
75MP0001851_eye_inflammation0.87947783
76MP0008007_abnormal_cellular_replicative0.87630867
77MP0003806_abnormal_nucleotide_metabolis0.87159461
78MP0003191_abnormal_cellular_cholesterol0.86736662
79MP0008004_abnormal_stomach_pH0.83340148
80MP0005164_abnormal_response_to0.83250884
81MP0004381_abnormal_hair_follicle0.77640996
82MP0000604_amyloidosis0.76813810
83* MP0002998_abnormal_bone_remodeling0.76518798
84MP0001986_abnormal_taste_sensitivity0.76489854
85MP0001663_abnormal_digestive_system0.75954339
86MP0000313_abnormal_cell_death0.75007390
87MP0003045_fibrosis0.74250285
88MP0002277_abnormal_respiratory_mucosa0.73931627
89MP0009840_abnormal_foam_cell0.69491601
90MP0009763_increased_sensitivity_to0.67634988
91MP0003828_pulmonary_edema0.65368774
92MP0000569_abnormal_digit_pigmentation0.65036790
93MP0002009_preneoplasia0.63476054
94MP0000371_diluted_coat_color0.61368589
95MP0008874_decreased_physiological_sensi0.61119619
96MP0005390_skeleton_phenotype0.61051622
97MP0003075_altered_response_to0.59928235
98MP0003656_abnormal_erythrocyte_physiolo0.59845568
99MP0005166_decreased_susceptibility_to0.55415857
100MP0004957_abnormal_blastocyst_morpholog0.54855206
101MP0000249_abnormal_blood_vessel0.54151174
102MP0010352_gastrointestinal_tract_polyps0.51582864
103MP0005319_abnormal_enzyme/_coenzyme0.51020310
104MP0002693_abnormal_pancreas_physiology0.50386511
105MP0006292_abnormal_olfactory_placode0.49699401
106MP0003786_premature_aging0.49298182
107* MP0003795_abnormal_bone_structure0.48471697
108MP0002138_abnormal_hepatobiliary_system0.48316264
109MP0000477_abnormal_intestine_morphology0.48230781
110MP0005381_digestive/alimentary_phenotyp0.48028722
111MP0002075_abnormal_coat/hair_pigmentati0.47120843
112MP0004130_abnormal_muscle_cell0.47063382
113MP0003943_abnormal_hepatobiliary_system0.46845175
114MP0003221_abnormal_cardiomyocyte_apopto0.45879022
115MP0000609_abnormal_liver_physiology0.45822134
116MP0002136_abnormal_kidney_physiology0.45518250
117MP0005076_abnormal_cell_differentiation0.45391387
118MP0009765_abnormal_xenobiotic_induced0.44932271
119MP0008873_increased_physiological_sensi0.44819847
120MP0005083_abnormal_biliary_tract0.42361743
121MP0002928_abnormal_bile_duct0.41749228
122MP0003091_abnormal_cell_migration0.40957742

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.56417795
2Eczematoid dermatitis (HP:0000976)5.19077173
3Recurrent bacterial skin infections (HP:0005406)4.87021320
4Recurrent fungal infections (HP:0002841)4.43328425
5Recurrent viral infections (HP:0004429)4.26960763
6Myositis (HP:0100614)4.14391010
7Gastrointestinal infarctions (HP:0005244)4.11485002
8Chronic otitis media (HP:0000389)4.05776054
9Cellulitis (HP:0100658)3.91341352
10* Meningitis (HP:0001287)3.89718867
11Panhypogammaglobulinemia (HP:0003139)3.86768758
12Elevated erythrocyte sedimentation rate (HP:0003565)3.81880814
13Agammaglobulinemia (HP:0004432)3.81042707
14Mediastinal lymphadenopathy (HP:0100721)3.74217757
15Hypochromic microcytic anemia (HP:0004840)3.73266071
16Recurrent bronchitis (HP:0002837)3.70008974
17Chronic mucocutaneous candidiasis (HP:0002728)3.67097296
18Recurrent cutaneous fungal infections (HP:0011370)3.67097296
19* IgM deficiency (HP:0002850)3.66343897
20Recurrent skin infections (HP:0001581)3.59981035
21T lymphocytopenia (HP:0005403)3.56227215
22Abnormality of macrophages (HP:0004311)3.46722468
23Abnormality of T cell number (HP:0011839)3.44088681
24* Chronic obstructive pulmonary disease (HP:0006510)3.41394858
25* Obstructive lung disease (HP:0006536)3.41394858
26Thrombocytosis (HP:0001894)3.37277097
27Recurrent gram-negative bacterial infections (HP:0005420)3.30369871
28* Urticaria (HP:0001025)3.28147777
29Abnormality of B cell number (HP:0010975)3.19286844
30B lymphocytopenia (HP:0010976)3.19286844
31Optic neuritis (HP:0100653)3.15417822
32Retrobulbar optic neuritis (HP:0100654)3.15417822
33* Abnormality of T cells (HP:0002843)3.11698599
34Pustule (HP:0200039)3.10958942
35Episodic fever (HP:0001954)3.09040198
36* Abnormal delayed hypersensitivity skin test (HP:0002963)3.06855530
37Orchitis (HP:0100796)3.05158046
38Stomatitis (HP:0010280)3.00091094
39* Vasculitis (HP:0002633)2.94886374
40Thyroiditis (HP:0100646)2.91638053
41IgG deficiency (HP:0004315)2.91522392
42* Prolonged bleeding time (HP:0003010)2.91108181
43Colitis (HP:0002583)2.87896289
44Nasal polyposis (HP:0100582)2.86851428
45Increased IgM level (HP:0003496)2.85076505
46* Inflammation of the large intestine (HP:0002037)2.83068502
47* Gastrointestinal inflammation (HP:0004386)2.78940940
48* Chest pain (HP:0100749)2.75018329
49Recurrent sinusitis (HP:0011108)2.73887077
50Granulocytopenia (HP:0001913)2.73711031
51Eosinophilia (HP:0001880)2.71158042
52Gingivitis (HP:0000230)2.70960852
53Anorexia (HP:0002039)2.69405320
54Recurrent pneumonia (HP:0006532)2.67058359
55Osteomyelitis (HP:0002754)2.65810695
56Severe combined immunodeficiency (HP:0004430)2.65089751
57* Abnormality of T cell physiology (HP:0011840)2.64614697
58Leukocytosis (HP:0001974)2.63367515
59* Petechiae (HP:0000967)2.61441484
60Vacuolated lymphocytes (HP:0001922)2.59488617
61* Lymphopenia (HP:0001888)2.58411513
62Abnormality of the fingertips (HP:0001211)2.56894660
63Amyloidosis (HP:0011034)2.52506430
64* Hypochromic anemia (HP:0001931)2.52232043
65* Abnormality of cells of the lymphoid lineage (HP:0012140)2.51992397
66Abnormality of the nasal mucosa (HP:0000433)2.50684669
67Abnormality of the prostate (HP:0008775)2.48575938
68Verrucae (HP:0200043)2.47550771
69Papilloma (HP:0012740)2.47550771
70Combined immunodeficiency (HP:0005387)2.46586697
71Gastrointestinal stroma tumor (HP:0100723)2.46493422
72Abnormality of eosinophils (HP:0001879)2.46146941
73Chronic sinusitis (HP:0011109)2.45715119
74Autoimmune thrombocytopenia (HP:0001973)2.45280692
75* Epistaxis (HP:0000421)2.45229952
76Abnormality of the pleura (HP:0002103)2.43015086
77* Lymphoma (HP:0002665)2.37462138
78Pulmonary infiltrates (HP:0002113)2.37382146
79Impaired platelet aggregation (HP:0003540)2.36684857
80Abnormal platelet function (HP:0011869)2.36684857
81Reticulocytopenia (HP:0001896)2.36038822
82Periodontitis (HP:0000704)2.34951154
83Chromsome breakage (HP:0040012)2.34515770
84Peritonitis (HP:0002586)2.32906515
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32526323
86* Encephalitis (HP:0002383)2.31304572
87Hemoptysis (HP:0002105)2.31112390
88Arterial thrombosis (HP:0004420)2.30924478
89IgA deficiency (HP:0002720)2.30733885
90Gangrene (HP:0100758)2.29406938
91Abnormal number of erythroid precursors (HP:0012131)2.27517841
92Chronic diarrhea (HP:0002028)2.26970010
93Premature loss of primary teeth (HP:0006323)2.24530091
94* Spontaneous hematomas (HP:0007420)2.24383819
95* Pulmonary embolism (HP:0002204)2.23955753
96Hepatosplenomegaly (HP:0001433)2.22625301
97Abnormality of cells of the erythroid lineage (HP:0012130)2.22103706
98Abnormality of liposaccharide metabolism (HP:0010968)2.22083579
99Abnormality of glycosphingolipid metabolism (HP:0004343)2.22083579
100Abnormality of glycolipid metabolism (HP:0010969)2.22083579
101* Increased IgE level (HP:0003212)2.20969277
102* Recurrent lower respiratory tract infections (HP:0002783)2.18801742
103Increased serum ferritin (HP:0003281)2.18056196
104Abnormality of the peritoneum (HP:0002585)2.17994168
105Loss of speech (HP:0002371)2.17530073
106Keratoconjunctivitis sicca (HP:0001097)2.15406813
107Myelodysplasia (HP:0002863)2.14370642
108Cheilitis (HP:0100825)2.13865687
109Autoimmune hemolytic anemia (HP:0001890)2.13765505
110Basal ganglia calcification (HP:0002135)2.13635033
111Restrictive lung disease (HP:0002091)2.10742323
112Albinism (HP:0001022)2.09934791
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09700811
114Leukopenia (HP:0001882)2.08479227
115Interstitial pulmonary disease (HP:0006530)2.07139374
116Increased neuronal autofluorescent lipopigment (HP:0002074)2.06031688
117Abnormality of the endocardium (HP:0004306)2.05825331
118* Gingival bleeding (HP:0000225)2.05148462
119* Sepsis (HP:0100806)2.04900299
120Clubbing of toes (HP:0100760)2.04688287
121Abnormality of iron homeostasis (HP:0011031)2.04523376
122Increased cerebral lipofuscin (HP:0011813)2.04339798
123Viral hepatitis (HP:0006562)2.03911660
124Skin rash (HP:0000988)2.03127889
125Agnosia (HP:0010524)2.02723195
126Slow saccadic eye movements (HP:0000514)2.02058936
127Bronchitis (HP:0012387)2.00884215
128* Skin ulcer (HP:0200042)2.00177855
129* Hypergammaglobulinemia (HP:0010702)1.97815098
130Acne (HP:0001061)1.97482701
131Aplastic anemia (HP:0001915)1.96548245
132Abnormality of the pericardium (HP:0001697)1.96247169
133Keratoconjunctivitis (HP:0001096)1.94686629
134Arthralgia (HP:0002829)1.94107908
135Prostate neoplasm (HP:0100787)1.93833390
136* Microcytic anemia (HP:0001935)1.93399253
137Polyneuropathy (HP:0001271)1.92664970
138Vertigo (HP:0002321)1.91879034
139Abnormality of DNA repair (HP:0003254)1.91712163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.83974582
2TXK3.20533045
3IRAK43.07560204
4BLK3.02968648
5PRPF4B2.60670691
6TYK22.34578864
7JAK32.21479302
8TEC2.20975330
9ZAP702.19205557
10IRAK32.16944188
11KIT2.12568949
12GRK62.07734900
13* BTK2.05013708
14MAP3K142.04004538
15EEF2K1.96498908
16SYK1.93560622
17IKBKE1.92789640
18STK101.92254388
19CSF1R1.83925275
20TAOK11.77085474
21MAP3K111.74789185
22CLK11.71756714
23TBK11.71420718
24FES1.71255512
25MAP3K101.65691740
26MAP3K31.62450884
27RIPK41.56659581
28ITK1.54649050
29IKBKB1.50793282
30CSK1.47831175
31PIM11.44413766
32* LCK1.38673555
33TGFBR21.38285379
34NME21.38113795
35JAK11.36566332
36* HCK1.36427990
37* LYN1.30374650
38TAOK31.25419083
39MAP2K31.22707405
40MAP3K11.21216368
41SIK21.17336595
42SMG11.16774390
43ERN11.16404049
44TRIB31.15047797
45NLK1.12872354
46PIM21.07472358
47LRRK21.04680566
48KSR21.02336244
49TAOK20.99692496
50CDK120.97211711
51MARK20.97112557
52MST40.93845372
53STK40.92133482
54FGFR30.92069947
55PDK10.91147367
56SIK30.86401302
57CDK40.85860911
58STK160.84699046
59RPS6KA40.84637197
60EPHB10.83569985
61CDK190.81396927
62CHUK0.80723426
63NEK20.78270994
64FGFR40.78129442
65MAPK120.77904654
66BMPR20.77868777
67MARK30.77655106
68YES10.77332810
69KDR0.75142718
70PDPK10.73471288
71PKN20.73212392
72CDC70.72335314
73CDC42BPA0.71691199
74HIPK20.71565274
75JAK20.71445120
76MAP3K70.70475445
77IRAK20.69214344
78MATK0.68508855
79MAPK70.68101649
80ATR0.67083468
81MKNK10.65308725
82VRK10.64312980
83TRPM70.63259372
84SIK10.62137913
85EIF2AK30.62091694
86BRD40.61636192
87PRKCQ0.59953409
88MAP3K130.59223978
89MAPK40.58951037
90RPS6KA60.57609369
91* FYN0.56917449
92MKNK20.55489364
93FLT30.54973334
94ADRBK20.52719904
95MAP3K60.52363497
96STK240.49862674
97ZAK0.49581732
98TGFBR10.49474564
99ALK0.49463482
100STK110.49351210
101CAMKK10.49249205
102IRAK10.48900637
103RPS6KL10.48809127
104RPS6KC10.48809127
105MAP2K20.48300517
106CDK70.48127779
107RPS6KA50.47086544
108DYRK1B0.47062617
109CDK90.46369495
110RPS6KB20.45840753
111MAPKAPK20.45406709
112EIF2AK20.44928544
113PASK0.44324337
114CDK60.43779579
115GRK70.43397963
116EPHA30.42878008
117MAP3K50.41415188
118MAPK110.40263474
119FGR0.39063627
120PIK3CG0.39027479
121TESK20.38391366
122PTK2B0.37707805
123RET0.37103745
124PLK40.36757952
125MAP2K60.36619109
126SRPK10.36325539
127PRKCD0.35832604
128CAMKK20.35631944
129PRKD20.35440208
130SGK30.35250538
131PRKCH0.35084157
132TSSK60.34822979
133MAP2K40.34322593
134NUAK10.33862161
135PTK60.33389600
136MAP3K80.31609181
137* TNK20.31264915
138RAF10.29528207

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.53302907
2Leishmaniasis_Homo sapiens_hsa051402.64208260
3B cell receptor signaling pathway_Homo sapiens_hsa046622.44211310
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.43720453
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.37721186
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30715702
7DNA replication_Homo sapiens_hsa030302.26878808
8Measles_Homo sapiens_hsa051622.26298898
9Osteoclast differentiation_Homo sapiens_hsa043802.15742334
10Hematopoietic cell lineage_Homo sapiens_hsa046402.06910267
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06669619
12Antigen processing and presentation_Homo sapiens_hsa046122.06369488
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94310053
14Ribosome_Homo sapiens_hsa030101.78648623
15T cell receptor signaling pathway_Homo sapiens_hsa046601.73111880
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72746536
17Herpes simplex infection_Homo sapiens_hsa051681.71572396
18Mismatch repair_Homo sapiens_hsa034301.70187541
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69971586
20Allograft rejection_Homo sapiens_hsa053301.67345109
21Graft-versus-host disease_Homo sapiens_hsa053321.64348868
22Other glycan degradation_Homo sapiens_hsa005111.62610610
23Base excision repair_Homo sapiens_hsa034101.58830090
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.53684381
25Staphylococcus aureus infection_Homo sapiens_hsa051501.53602266
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49800440
27* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46959629
28Asthma_Homo sapiens_hsa053101.45158941
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44113253
30Homologous recombination_Homo sapiens_hsa034401.40279530
31Legionellosis_Homo sapiens_hsa051341.36920543
32Tuberculosis_Homo sapiens_hsa051521.35317513
33Pertussis_Homo sapiens_hsa051331.32480518
34Non-homologous end-joining_Homo sapiens_hsa034501.32311856
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.29554753
36Influenza A_Homo sapiens_hsa051641.28969031
37Acute myeloid leukemia_Homo sapiens_hsa052211.28079365
38Toxoplasmosis_Homo sapiens_hsa051451.27459215
39* Chemokine signaling pathway_Homo sapiens_hsa040621.25172182
40Hepatitis B_Homo sapiens_hsa051611.22253941
41Malaria_Homo sapiens_hsa051441.21777379
42Apoptosis_Homo sapiens_hsa042101.21268179
43Fanconi anemia pathway_Homo sapiens_hsa034601.20281935
44Spliceosome_Homo sapiens_hsa030401.18274474
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15592004
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13953843
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13715412
48* Shigellosis_Homo sapiens_hsa051311.12347950
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.09684069
50Epstein-Barr virus infection_Homo sapiens_hsa051691.06600228
51TNF signaling pathway_Homo sapiens_hsa046681.03613574
52Nucleotide excision repair_Homo sapiens_hsa034201.02737394
53Platelet activation_Homo sapiens_hsa046110.98491211
54Autoimmune thyroid disease_Homo sapiens_hsa053200.98191696
55Chronic myeloid leukemia_Homo sapiens_hsa052200.94581296
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93096281
57Viral myocarditis_Homo sapiens_hsa054160.89172380
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88598873
59* Salmonella infection_Homo sapiens_hsa051320.84945227
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84596179
61Viral carcinogenesis_Homo sapiens_hsa052030.83112832
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82675427
63Lysosome_Homo sapiens_hsa041420.80408039
64HTLV-I infection_Homo sapiens_hsa051660.76996298
65Pancreatic cancer_Homo sapiens_hsa052120.76952085
66Cell cycle_Homo sapiens_hsa041100.76923195
67Pyrimidine metabolism_Homo sapiens_hsa002400.72823995
68Renal cell carcinoma_Homo sapiens_hsa052110.70599922
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70471125
70Hepatitis C_Homo sapiens_hsa051600.70285982
71RNA degradation_Homo sapiens_hsa030180.70232561
72p53 signaling pathway_Homo sapiens_hsa041150.69785236
73Rheumatoid arthritis_Homo sapiens_hsa053230.68820188
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.68089494
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66692146
76* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66551554
77* Endocytosis_Homo sapiens_hsa041440.65533209
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61758545
79Systemic lupus erythematosus_Homo sapiens_hsa053220.61356145
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.61112190
81Notch signaling pathway_Homo sapiens_hsa043300.59150700
82Non-small cell lung cancer_Homo sapiens_hsa052230.58951761
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.58223107
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58075980
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.56515416
86Prolactin signaling pathway_Homo sapiens_hsa049170.55738912
87Type I diabetes mellitus_Homo sapiens_hsa049400.55487296
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54266237
89Endometrial cancer_Homo sapiens_hsa052130.51999146
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50306552
91GnRH signaling pathway_Homo sapiens_hsa049120.48851438
92African trypanosomiasis_Homo sapiens_hsa051430.48689628
93RNA polymerase_Homo sapiens_hsa030200.48446123
94One carbon pool by folate_Homo sapiens_hsa006700.48097907
95Colorectal cancer_Homo sapiens_hsa052100.47432319
96RNA transport_Homo sapiens_hsa030130.47279041
97Phagosome_Homo sapiens_hsa041450.46915230
98Amoebiasis_Homo sapiens_hsa051460.46904818
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46350932
100Small cell lung cancer_Homo sapiens_hsa052220.45156185
101MAPK signaling pathway_Homo sapiens_hsa040100.44553085
102* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43217539
103mTOR signaling pathway_Homo sapiens_hsa041500.42890736
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.41598985
105mRNA surveillance pathway_Homo sapiens_hsa030150.41080279
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40599560
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40100002
108Insulin resistance_Homo sapiens_hsa049310.40011118
109* Choline metabolism in cancer_Homo sapiens_hsa052310.39842956
110Basal transcription factors_Homo sapiens_hsa030220.39677147
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38864631
112Regulation of autophagy_Homo sapiens_hsa041400.38112811
113VEGF signaling pathway_Homo sapiens_hsa043700.37235752
114Dorso-ventral axis formation_Homo sapiens_hsa043200.37013211
115Type II diabetes mellitus_Homo sapiens_hsa049300.36354091
116Proteasome_Homo sapiens_hsa030500.35289570
117FoxO signaling pathway_Homo sapiens_hsa040680.35029856
118Rap1 signaling pathway_Homo sapiens_hsa040150.34596838
119N-Glycan biosynthesis_Homo sapiens_hsa005100.34331173
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30338739
121HIF-1 signaling pathway_Homo sapiens_hsa040660.29903414
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29505410
123Prostate cancer_Homo sapiens_hsa052150.29323948
124Pentose phosphate pathway_Homo sapiens_hsa000300.28773357
125Inositol phosphate metabolism_Homo sapiens_hsa005620.27672444
126ErbB signaling pathway_Homo sapiens_hsa040120.27212000
127Estrogen signaling pathway_Homo sapiens_hsa049150.23848015
128Insulin signaling pathway_Homo sapiens_hsa049100.21506227

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