VWA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.33139180
2L-phenylalanine catabolic process (GO:0006559)6.33139180
3actin-myosin filament sliding (GO:0033275)6.31309645
4muscle filament sliding (GO:0030049)6.31309645
5L-phenylalanine metabolic process (GO:0006558)6.11590745
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.11590745
7sarcoplasmic reticulum calcium ion transport (GO:0070296)5.81055345
8aromatic amino acid family catabolic process (GO:0009074)5.62816236
9alpha-linolenic acid metabolic process (GO:0036109)5.56218851
10lysine catabolic process (GO:0006554)5.54776725
11lysine metabolic process (GO:0006553)5.54776725
12actin-mediated cell contraction (GO:0070252)5.48561775
13glyoxylate metabolic process (GO:0046487)5.31015561
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29293080
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.22160522
16kynurenine metabolic process (GO:0070189)5.17001974
17tryptophan catabolic process (GO:0006569)5.04902647
18indole-containing compound catabolic process (GO:0042436)5.04902647
19indolalkylamine catabolic process (GO:0046218)5.04902647
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.97054237
21bile acid biosynthetic process (GO:0006699)4.94489450
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.91159991
23myofibril assembly (GO:0030239)4.86955843
24cysteine metabolic process (GO:0006534)4.81730167
25tryptophan metabolic process (GO:0006568)4.79686628
26amino-acid betaine metabolic process (GO:0006577)4.75947162
27sulfur amino acid catabolic process (GO:0000098)4.70601161
28urea cycle (GO:0000050)4.61980146
29urea metabolic process (GO:0019627)4.61980146
30sarcomere organization (GO:0045214)4.61792470
31regulation of relaxation of muscle (GO:1901077)4.56295129
32actin filament-based movement (GO:0030048)4.56124951
33regulation of triglyceride catabolic process (GO:0010896)4.54849971
34fatty acid beta-oxidation (GO:0006635)4.53129285
35nuclear pore complex assembly (GO:0051292)4.51806992
36skeletal muscle contraction (GO:0003009)4.50973437
37cellular ketone body metabolic process (GO:0046950)4.50372850
38negative regulation of potassium ion transmembrane transport (GO:1901380)4.49888579
39homocysteine metabolic process (GO:0050667)4.47662689
40serine family amino acid catabolic process (GO:0009071)4.45094368
41regulation of skeletal muscle contraction (GO:0014819)4.44545965
42cardiac muscle hypertrophy (GO:0003300)4.39274390
43high-density lipoprotein particle remodeling (GO:0034375)4.37437710
44short-chain fatty acid metabolic process (GO:0046459)4.36686211
452-oxoglutarate metabolic process (GO:0006103)4.36467954
46negative regulation of fibrinolysis (GO:0051918)4.29910635
47peptidyl-glutamic acid carboxylation (GO:0017187)4.28070620
48protein carboxylation (GO:0018214)4.28070620
49acetyl-CoA metabolic process (GO:0006084)4.27387366
50bile acid metabolic process (GO:0008206)4.27173461
51fatty acid oxidation (GO:0019395)4.27124249
52cardiac myofibril assembly (GO:0055003)4.26879065
53complement activation, alternative pathway (GO:0006957)4.25068324
54nitrogen cycle metabolic process (GO:0071941)4.25025301
55aspartate family amino acid catabolic process (GO:0009068)4.24176499
56fatty acid transmembrane transport (GO:1902001)4.21815596
57alpha-amino acid catabolic process (GO:1901606)4.20649779
58lipid oxidation (GO:0034440)4.19351882
59positive regulation of fatty acid beta-oxidation (GO:0032000)4.18153741
60striated muscle hypertrophy (GO:0014897)4.16018219
61regulation of protein activation cascade (GO:2000257)4.15988522
62fatty acid catabolic process (GO:0009062)4.14098767
63triglyceride homeostasis (GO:0070328)4.10555839
64acylglycerol homeostasis (GO:0055090)4.10555839
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.10033788
66aromatic amino acid family metabolic process (GO:0009072)4.09491034
67regulation of fibrinolysis (GO:0051917)4.07429197
68carnitine shuttle (GO:0006853)4.03478930
69striated muscle contraction (GO:0006941)4.02012573
70carnitine metabolic process (GO:0009437)4.01232502
71dicarboxylic acid biosynthetic process (GO:0043650)4.01073138
72monocarboxylic acid catabolic process (GO:0072329)3.99779299
73valine metabolic process (GO:0006573)3.99028458
74cellular amino acid catabolic process (GO:0009063)3.98682157
75tyrosine metabolic process (GO:0006570)3.98215297
76glycogen catabolic process (GO:0005980)3.96756436
77ethanol oxidation (GO:0006069)3.94482984
78ketone body metabolic process (GO:1902224)3.92830730
79reverse cholesterol transport (GO:0043691)3.92242771
80cellular modified amino acid catabolic process (GO:0042219)3.91101235
81regulation of complement activation (GO:0030449)3.90328695
82glutamate metabolic process (GO:0006536)3.90064808
83plasma lipoprotein particle clearance (GO:0034381)3.89594907
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.89529040
85NADH metabolic process (GO:0006734)3.89115572
86plasma lipoprotein particle remodeling (GO:0034369)3.85557768
87protein-lipid complex remodeling (GO:0034368)3.85557768
88macromolecular complex remodeling (GO:0034367)3.85557768
89phospholipid homeostasis (GO:0055091)3.83394599
90regulation of cholesterol esterification (GO:0010872)3.80221426
91coenzyme catabolic process (GO:0009109)3.79033011
92positive regulation of lipid catabolic process (GO:0050996)3.78757538
93carboxylic acid catabolic process (GO:0046395)3.77527634
94organic acid catabolic process (GO:0016054)3.77527634
95negative regulation of sterol transport (GO:0032372)3.75374475
96negative regulation of cholesterol transport (GO:0032375)3.75374475
97drug transmembrane transport (GO:0006855)3.74610757
98nuclear pore organization (GO:0006999)3.74108365
99drug catabolic process (GO:0042737)3.73820707
100regulation of actin filament-based movement (GO:1903115)3.73437097
101cardiac muscle contraction (GO:0060048)3.72591920
102glucan catabolic process (GO:0009251)3.71682331
103phospholipid efflux (GO:0033700)3.70627302
104regulation of cholesterol homeostasis (GO:2000188)3.69405098
105creatine metabolic process (GO:0006600)3.68469806
106positive regulation of fatty acid oxidation (GO:0046321)3.66504722
107actomyosin structure organization (GO:0031032)3.63793471
108biotin metabolic process (GO:0006768)3.62308118
109regulation of fatty acid beta-oxidation (GO:0031998)3.61653492
110branched-chain amino acid catabolic process (GO:0009083)3.61209138
111skeletal muscle adaptation (GO:0043501)3.59717154
112cellular glucuronidation (GO:0052695)3.58652625
113muscle hypertrophy (GO:0014896)3.57356369
114cellular polysaccharide catabolic process (GO:0044247)3.57019480
115indolalkylamine metabolic process (GO:0006586)3.56718513
116bile acid and bile salt transport (GO:0015721)3.55657150
117benzene-containing compound metabolic process (GO:0042537)3.54731814
118serine family amino acid metabolic process (GO:0009069)3.51619369
119branched-chain amino acid metabolic process (GO:0009081)3.50874658
120glycine metabolic process (GO:0006544)3.47180437
121urate metabolic process (GO:0046415)3.46249098
122regulation of sequestering of triglyceride (GO:0010889)3.44751316
123tricarboxylic acid metabolic process (GO:0072350)3.41835255
124cardiac muscle hypertrophy in response to stress (GO:0014898)3.41363811
125muscle hypertrophy in response to stress (GO:0003299)3.41363811
126cardiac muscle adaptation (GO:0014887)3.41363811
127regulation of fatty acid oxidation (GO:0046320)3.38992584
128negative regulation of lipase activity (GO:0060192)3.38864220
129regulation of bile acid biosynthetic process (GO:0070857)3.38672006
130positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.38438724
131cholesterol efflux (GO:0033344)3.37459849
132striated muscle adaptation (GO:0014888)3.35743661
133amino-acid betaine transport (GO:0015838)3.35368992
134carnitine transport (GO:0015879)3.35368992
135regulation of cholesterol metabolic process (GO:0090181)3.35144148
136amine catabolic process (GO:0009310)3.33549656
137response to muscle activity (GO:0014850)3.30733785
138regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.27958544
139polysaccharide catabolic process (GO:0000272)3.27198226
140regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.25951907
141blood coagulation, intrinsic pathway (GO:0007597)3.20748982
142peptidyl-lysine dimethylation (GO:0018027)3.12591372
143regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.10032787
144tricarboxylic acid cycle (GO:0006099)3.08721699
145muscle contraction (GO:0006936)3.04816519
146pore complex assembly (GO:0046931)3.03940001
147carnitine transmembrane transport (GO:1902603)3.02886831
148interkinetic nuclear migration (GO:0022027)2.94268579
149ventricular cardiac muscle cell action potential (GO:0086005)2.90083848
150cell-substrate junction assembly (GO:0007044)2.85337793
151hypotonic response (GO:0006971)2.83941643
152response to epinephrine (GO:0071871)2.80861049
153cellular response to epinephrine stimulus (GO:0071872)2.80197976
154muscle system process (GO:0003012)2.79862727
155cardiac muscle tissue morphogenesis (GO:0055008)2.79646191
156muscle tissue morphogenesis (GO:0060415)2.75500049
157response to inactivity (GO:0014854)2.70163086
158focal adhesion assembly (GO:0048041)2.70049203
159cell-substrate adherens junction assembly (GO:0007045)2.70049203
160regulation of cell communication by electrical coupling (GO:0010649)2.67985993
161regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.64879116
162positive regulation of cation channel activity (GO:2001259)2.63496321
163adult heart development (GO:0007512)2.62462767
164regulation of the force of heart contraction (GO:0002026)2.62277937
165fatty acid homeostasis (GO:0055089)2.62276236
166relaxation of muscle (GO:0090075)2.60756678
167skeletal muscle tissue regeneration (GO:0043403)2.60192809
168striated muscle atrophy (GO:0014891)2.57690344
169relaxation of cardiac muscle (GO:0055119)2.56325110
170negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.56111282
171cardiac muscle cell development (GO:0055013)2.55675508
172negative regulation of protein localization to plasma membrane (GO:1903077)2.55334470
173mitotic sister chromatid cohesion (GO:0007064)2.55269345
174muscle adaptation (GO:0043500)2.54734698
175bundle of His cell to Purkinje myocyte communication (GO:0086069)2.52518782
176oxaloacetate metabolic process (GO:0006107)2.52330213
177regulation of lipoprotein metabolic process (GO:0050746)2.51777189
178intracellular lipid transport (GO:0032365)2.50990301
179regulation of platelet aggregation (GO:0090330)2.50533118
180regulation of striated muscle contraction (GO:0006942)2.47408165
181cellular carbohydrate catabolic process (GO:0044275)2.46666439
182histone H3-K36 demethylation (GO:0070544)2.45634117
183glycogen metabolic process (GO:0005977)2.44356181
184negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.44006258
185cardiac cell development (GO:0055006)2.42733628
186adherens junction assembly (GO:0034333)2.41625059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.24410773
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.36399131
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.33202078
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.83318953
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.10336145
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.60515029
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96969320
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.63546080
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.09846488
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72616873
11E2F7_22180533_ChIP-Seq_HELA_Human2.60506753
12CLOCK_20551151_ChIP-Seq_293T_Human2.13750488
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03125184
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02547572
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0638181
16GATA1_22025678_ChIP-Seq_K562_Human1.89608175
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.83020533
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82062148
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.78503697
20CTNNB1_20460455_ChIP-Seq_HCT116_Human1.77020506
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.70063323
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67975743
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60704208
24NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.58770459
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58616166
26GATA4_21415370_ChIP-Seq_HL-1_Mouse1.58143868
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57661896
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51181670
29SCL_19346495_ChIP-Seq_HPC-7_Human1.50839435
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47865456
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.47531401
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47292882
33GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46981717
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46766539
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45435925
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41882633
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.41819356
38HNF4A_19822575_ChIP-Seq_HepG2_Human1.40135701
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39902133
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37810122
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37614956
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31767289
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30483872
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30183092
45ZNF263_19887448_ChIP-Seq_K562_Human1.29961327
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29229439
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28268258
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28268258
49MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24906928
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.24554819
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23484939
52GATA1_19941827_ChIP-Seq_MEL86_Mouse1.22680990
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19297824
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18288771
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17811738
56AR_21909140_ChIP-Seq_LNCAP_Human1.17175476
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17058051
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.15598303
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11345045
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.11313248
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.11313248
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.10611265
63SPI1_23127762_ChIP-Seq_K562_Human1.07603111
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07473727
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07392201
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07027769
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06095315
68TCF7_22412390_ChIP-Seq_EML_Mouse1.04280311
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02992715
70TP53_16413492_ChIP-PET_HCT116_Human1.02929531
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02746303
72HTT_18923047_ChIP-ChIP_STHdh_Human1.02431327
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99037857
74ESR1_21235772_ChIP-Seq_MCF-7_Human0.98696781
75RUNX_20019798_ChIP-Seq_JUKART_Human0.97960003
76YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97411423
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.97101029
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96943541
79POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95566873
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94756106
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94587934
82GATA4_25053715_ChIP-Seq_YYC3_Human0.94558952
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93580073
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92895996
85PU_27001747_Chip-Seq_BMDM_Mouse0.91911768
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91209772
87AR_21572438_ChIP-Seq_LNCaP_Human0.90306451
88EP300_21415370_ChIP-Seq_HL-1_Mouse0.90140061
89MYC_22102868_ChIP-Seq_BL_Human0.88490442
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88290300
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87891753
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87319136
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86263149
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.85734209
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85095016
96RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84321330
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83926868
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80972566
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80972566
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79204788
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77761662
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77682956
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77375006
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77222176
105LXR_22292898_ChIP-Seq_THP-1_Human0.75072488
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73726087
107GATA1_19941826_ChIP-Seq_K562_Human0.71911135
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71064878
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70710320
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70237736
111BCAT_22108803_ChIP-Seq_LS180_Human0.69378109
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68942006
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67128154
114GATA2_19941826_ChIP-Seq_K562_Human0.66396922
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.64622117
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63335060
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61538902
118FOXA1_25552417_ChIP-Seq_VCAP_Human0.61426660
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.60532323
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.59717182
121GATA6_25053715_ChIP-Seq_YYC3_Human0.59591539
122CEBPB_22108803_ChIP-Seq_LS180_Human0.59334672
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.59333319
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.58348813
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58217208
126RACK7_27058665_Chip-Seq_MCF-7_Human0.58106377
127EGR1_19032775_ChIP-ChIP_M12_Human0.56873614
128CBP_21632823_ChIP-Seq_H3396_Human0.56737975
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.55577713
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55562826
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.55094438
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55005813
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54052310
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53524539
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.53054673
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52857709
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.52730912
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52726976
139ZNF217_24962896_ChIP-Seq_MCF-7_Human0.51532309
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.50309750
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49958843
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.49906649
143IRF8_22096565_ChIP-ChIP_GC-B_Human0.49687786
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49417333
145STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49298215
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.48893509
147SOX2_20726797_ChIP-Seq_SW620_Human0.48747426
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.48663114
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.48646511
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.48475757
151CDX2_22108803_ChIP-Seq_LS180_Human0.48267145
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.48128446

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.36976101
2MP0005360_urolithiasis6.76091279
3MP0005085_abnormal_gallbladder_physiolo5.63642529
4MP0005365_abnormal_bile_salt5.60982997
5MP0008875_abnormal_xenobiotic_pharmacok4.31384871
6MP0003252_abnormal_bile_duct3.72427660
7MP0003806_abnormal_nucleotide_metabolis3.45890521
8MP0010329_abnormal_lipoprotein_level3.37645374
9MP0004145_abnormal_muscle_electrophysio3.09561386
10MP0005332_abnormal_amino_acid2.90004384
11MP0009840_abnormal_foam_cell2.79527243
12MP0003195_calcinosis2.73256095
13MP0005083_abnormal_biliary_tract2.64092618
14MP0004233_abnormal_muscle_weight2.61259354
15MP0001666_abnormal_nutrient_absorption2.44465024
16MP0005464_abnormal_platelet_physiology2.34926867
17MP0002106_abnormal_muscle_physiology2.29000436
18MP0000759_abnormal_skeletal_muscle2.26145212
19MP0002118_abnormal_lipid_homeostasis2.21281053
20MP0002837_dystrophic_cardiac_calcinosis2.20355172
21MP0005670_abnormal_white_adipose2.17015342
22MP0003191_abnormal_cellular_cholesterol2.07833816
23MP0000609_abnormal_liver_physiology2.04954313
24MP0004019_abnormal_vitamin_homeostasis2.04656333
25MP0004130_abnormal_muscle_cell1.98458405
26MP0008057_abnormal_DNA_replication1.93291892
27MP0003828_pulmonary_edema1.89767368
28MP0005369_muscle_phenotype1.85229434
29MP0005319_abnormal_enzyme/_coenzyme1.83435094
30MP0004484_altered_response_of1.83007573
31MP0003566_abnormal_cell_adhesion1.82647862
32MP0002138_abnormal_hepatobiliary_system1.79645522
33MP0010352_gastrointestinal_tract_polyps1.76712957
34MP0004510_myositis1.73295763
35MP0005584_abnormal_enzyme/coenzyme_acti1.63139364
36MP0003868_abnormal_feces_composition1.57819718
37MP0005666_abnormal_adipose_tissue1.56376835
38MP0009643_abnormal_urine_homeostasis1.56170052
39MP0002877_abnormal_melanocyte_morpholog1.54562340
40MP0003705_abnormal_hypodermis_morpholog1.54211853
41MP0002009_preneoplasia1.53642238
42MP0000733_abnormal_muscle_development1.52911540
43MP0003646_muscle_fatigue1.39397119
44MP0006036_abnormal_mitochondrial_physio1.37820436
45MP0005451_abnormal_body_composition1.34064628
46MP0002971_abnormal_brown_adipose1.31134305
47MP0003950_abnormal_plasma_membrane1.30543203
48MP0001764_abnormal_homeostasis1.29482462
49MP0002127_abnormal_cardiovascular_syste1.20832987
50MP0004043_abnormal_pH_regulation1.19165637
51MP0010234_abnormal_vibrissa_follicle1.18868977
52MP0005409_darkened_coat_color1.15550142
53MP0000750_abnormal_muscle_regeneration1.12061922
54MP0002078_abnormal_glucose_homeostasis1.11892268
55MP0005330_cardiomyopathy1.10722524
56MP0008004_abnormal_stomach_pH1.08159877
57MP0005535_abnormal_body_temperature1.07274934
58MP0002108_abnormal_muscle_morphology1.06211129
59MP0000013_abnormal_adipose_tissue1.04177401
60MP0003941_abnormal_skin_development1.03109313
61MP0000598_abnormal_liver_morphology1.02745203
62MP0003186_abnormal_redox_activity1.02733363
63MP0003045_fibrosis1.02570319
64MP0004036_abnormal_muscle_relaxation0.99455085
65MP0005334_abnormal_fat_pad0.98479158
66MP0003091_abnormal_cell_migration0.97638841
67MP0005636_abnormal_mineral_homeostasis0.97514348
68MP0004084_abnormal_cardiac_muscle0.95658520
69MP0002128_abnormal_blood_circulation0.95283387
70MP0001756_abnormal_urination0.94501472
71MP0001730_embryonic_growth_arrest0.93875492
72MP0010368_abnormal_lymphatic_system0.93316281
73MP0004185_abnormal_adipocyte_glucose0.92979208
74MP0002254_reproductive_system_inflammat0.92706224
75MP0001915_intracranial_hemorrhage0.92460516
76MP0005647_abnormal_sex_gland0.91893063
77MP0000604_amyloidosis0.91589102
78MP0004272_abnormal_basement_membrane0.91163466
79MP0005375_adipose_tissue_phenotype0.90873427
80MP0003656_abnormal_erythrocyte_physiolo0.90871554
81MP0002396_abnormal_hematopoietic_system0.90560042
82MP0002166_altered_tumor_susceptibility0.90215741
83MP0000751_myopathy0.90036587
84MP0005076_abnormal_cell_differentiation0.87827034
85MP0002269_muscular_atrophy0.87528375
86MP0004215_abnormal_myocardial_fiber0.87105790
87MP0003011_delayed_dark_adaptation0.86033488
88MP0009697_abnormal_copulation0.85309279
89MP0001661_extended_life_span0.85210091
90MP0004808_abnormal_hematopoietic_stem0.84877845
91MP0003453_abnormal_keratinocyte_physiol0.84751612
92MP0000266_abnormal_heart_morphology0.83764307
93MP0009642_abnormal_blood_homeostasis0.83479858
94MP0009763_increased_sensitivity_to0.81434098
95MP0003984_embryonic_growth_retardation0.81282953
96MP0006035_abnormal_mitochondrial_morpho0.79238960
97MP0009672_abnormal_birth_weight0.79058244
98MP0005275_abnormal_skin_tensile0.77865484
99MP0004087_abnormal_muscle_fiber0.77841576
100MP0005023_abnormal_wound_healing0.76898311
101MP0002088_abnormal_embryonic_growth/wei0.76737080
102MP0009764_decreased_sensitivity_to0.76165661
103MP0005266_abnormal_metabolism0.75408211
104MP0004134_abnormal_chest_morphology0.75381781
105MP0002086_abnormal_extraembryonic_tissu0.74703877
106MP0008438_abnormal_cutaneous_collagen0.74627614
107MP0003690_abnormal_glial_cell0.74319911
108MP0002876_abnormal_thyroid_physiology0.72906137
109MP0005448_abnormal_energy_balance0.72335662
110MP0004085_abnormal_heartbeat0.71738099
111MP0008775_abnormal_heart_ventricle0.71668408
112MP0000230_abnormal_systemic_arterial0.71316624
113MP0000749_muscle_degeneration0.71008793
114MP0001849_ear_inflammation0.68229742
115MP0005376_homeostasis/metabolism_phenot0.67604382
116MP0008961_abnormal_basal_metabolism0.67416027
117MP0009115_abnormal_fat_cell0.67223724
118MP0003329_amyloid_beta_deposits0.66828693
119MP0008469_abnormal_protein_level0.64982413
120MP0001544_abnormal_cardiovascular_syste0.64768839
121MP0005385_cardiovascular_system_phenoty0.64768839
122MP0001765_abnormal_ion_homeostasis0.64723833
123MP0002136_abnormal_kidney_physiology0.64396864
124MP0005220_abnormal_exocrine_pancreas0.64298233
125MP0005084_abnormal_gallbladder_morpholo0.64277763
126MP0005165_increased_susceptibility_to0.64035338
127MP0003300_gastrointestinal_ulcer0.63451902
128MP0010678_abnormal_skin_adnexa0.63427500
129MP0000747_muscle_weakness0.63402019
130MP0005620_abnormal_muscle_contractility0.61057094
131MP0010630_abnormal_cardiac_muscle0.61001067
132MP0001672_abnormal_embryogenesis/_devel0.59768566
133MP0005380_embryogenesis_phenotype0.59768566
134MP0006138_congestive_heart_failure0.59736348
135MP0003763_abnormal_thymus_physiology0.59525997
136MP0002972_abnormal_cardiac_muscle0.59458570
137MP0003953_abnormal_hormone_level0.59113883
138MP0009703_decreased_birth_body0.58456562
139MP0002970_abnormal_white_adipose0.58323480
140MP0005621_abnormal_cell_physiology0.57140495
141MP0005058_abnormal_lysosome_morphology0.56757409
142MP0009780_abnormal_chondrocyte_physiolo0.55947460
143MP0002168_other_aberrant_phenotype0.53503588
144MP0009384_cardiac_valve_regurgitation0.51938585
145MP0002928_abnormal_bile_duct0.51055788
146MP0002909_abnormal_adrenal_gland0.44647061
147MP0009765_abnormal_xenobiotic_induced0.44584823
148MP0005408_hypopigmentation0.44477391
149MP0003221_abnormal_cardiomyocyte_apopto0.44192232
150MP0002332_abnormal_exercise_endurance0.43499882
151MP0008874_decreased_physiological_sensi0.42495288
152MP0000003_abnormal_adipose_tissue0.41066935
153MP0003959_abnormal_lean_body0.41045130

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.36608034
2Nemaline bodies (HP:0003798)7.32328698
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.15865715
4Intrahepatic cholestasis (HP:0001406)5.86663016
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.68832903
6Deep venous thrombosis (HP:0002625)5.67501879
7Type 1 muscle fiber predominance (HP:0003803)5.45774051
8Xanthomatosis (HP:0000991)5.40213542
9Abnormality of monocarboxylic acid metabolism (HP:0010996)5.06182252
10Hypoglycemic coma (HP:0001325)4.88627423
11Ketosis (HP:0001946)4.84605690
12Hyperglycinuria (HP:0003108)4.83123283
13Hyperammonemia (HP:0001987)4.75624575
14Hypobetalipoproteinemia (HP:0003563)4.69523770
15Prolonged partial thromboplastin time (HP:0003645)4.56424198
16Hyperlipoproteinemia (HP:0010980)4.50668005
17Abnormality of serine family amino acid metabolism (HP:0010894)4.44890924
18Abnormality of glycine metabolism (HP:0010895)4.44890924
19Hyporeflexia of lower limbs (HP:0002600)4.35835160
20Ketoacidosis (HP:0001993)4.30442847
21Subaortic stenosis (HP:0001682)4.27938509
22Abnormality of the left ventricular outflow tract (HP:0011103)4.27938509
23Hyperglycinemia (HP:0002154)4.27722443
24Abnormality of fatty-acid metabolism (HP:0004359)4.22929233
25EMG: myopathic abnormalities (HP:0003458)4.08885252
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07987835
27Hypolipoproteinemia (HP:0010981)4.07229266
28Complement deficiency (HP:0004431)4.07191185
29Hypoalphalipoproteinemia (HP:0003233)4.04138657
30Centrally nucleated skeletal muscle fibers (HP:0003687)3.93065073
31Muscle hypertrophy of the lower extremities (HP:0008968)3.91505683
32Epidermoid cyst (HP:0200040)3.89375087
33Bundle branch block (HP:0011710)3.77637732
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74876089
35Muscle fiber splitting (HP:0003555)3.74255423
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.71243817
37Calf muscle hypertrophy (HP:0008981)3.67385719
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.60060391
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.53282807
40Abnormality of the calf musculature (HP:0001430)3.47067451
41Abnormality of skeletal muscle fiber size (HP:0012084)3.46726865
42Dicarboxylic aciduria (HP:0003215)3.45804476
43Abnormality of dicarboxylic acid metabolism (HP:0010995)3.45804476
44Abnormality of the common coagulation pathway (HP:0010990)3.42987847
45Rimmed vacuoles (HP:0003805)3.40556480
46Distal arthrogryposis (HP:0005684)3.37702762
47Joint hemorrhage (HP:0005261)3.37630408
48Neck muscle weakness (HP:0000467)3.36993857
49Increased connective tissue (HP:0009025)3.34057906
50Difficulty running (HP:0009046)3.33093079
51Distal lower limb muscle weakness (HP:0009053)3.29370277
52Myopathic facies (HP:0002058)3.26914746
53Fat malabsorption (HP:0002630)3.23806926
54Ventricular tachycardia (HP:0004756)3.23550945
55Abnormality of methionine metabolism (HP:0010901)3.20847368
56Increased mean platelet volume (HP:0011877)3.19447769
57Myoglobinuria (HP:0002913)3.19136343
58Gout (HP:0001997)3.09759315
59Abnormality of purine metabolism (HP:0004352)3.06604640
60Metabolic acidosis (HP:0001942)3.06212886
61Hypercholesterolemia (HP:0003124)3.05264026
62Increased variability in muscle fiber diameter (HP:0003557)3.04066987
63Distal lower limb amyotrophy (HP:0008944)3.02599767
64Abnormality of the intrinsic pathway (HP:0010989)2.99795341
65Generalized aminoaciduria (HP:0002909)2.95659802
66Conjugated hyperbilirubinemia (HP:0002908)2.94757286
67Menorrhagia (HP:0000132)2.94103414
68Abnormality of serum amino acid levels (HP:0003112)2.91365168
69Skin nodule (HP:0200036)2.88212757
70Abnormality of nucleobase metabolism (HP:0010932)2.88102009
71Abnormal platelet volume (HP:0011876)2.86611783
72Hypoglycemic seizures (HP:0002173)2.85732059
73Abnormality of complement system (HP:0005339)2.82889259
74Asymmetric septal hypertrophy (HP:0001670)2.82734169
75Hyperbilirubinemia (HP:0002904)2.82612046
76Delayed CNS myelination (HP:0002188)2.82554970
77Papillary thyroid carcinoma (HP:0002895)2.81176579
78Dysmetric saccades (HP:0000641)2.78659579
79Ulnar deviation of the wrist (HP:0003049)2.72503385
80Hyperinsulinemic hypoglycemia (HP:0000825)2.70666795
81Dilated cardiomyopathy (HP:0001644)2.69013380
82Prolonged bleeding time (HP:0003010)2.66786023
83Lethargy (HP:0001254)2.66627286
84EMG: neuropathic changes (HP:0003445)2.63476202
85Proximal tubulopathy (HP:0000114)2.62502035
86Round ear (HP:0100830)2.60561264
87Cerebral edema (HP:0002181)2.54867906
88Abnormality of proline metabolism (HP:0010907)2.52711310
89Hydroxyprolinuria (HP:0003080)2.52711310
90Myocardial infarction (HP:0001658)2.52307247
91Hepatocellular carcinoma (HP:0001402)2.51490459
92Abnormality of pyrimidine metabolism (HP:0004353)2.51096745
93Areflexia of lower limbs (HP:0002522)2.48304299
94Hyperkalemia (HP:0002153)2.43943017
95Rhabdomyolysis (HP:0003201)2.43852935
96Gingival bleeding (HP:0000225)2.41323979
97Lipoatrophy (HP:0100578)2.41253481
98Progressive muscle weakness (HP:0003323)2.39458872
99Late onset (HP:0003584)2.39103891
100Mildly elevated creatine phosphokinase (HP:0008180)2.38081553
101Increased purine levels (HP:0004368)2.38049371
102Hyperuricemia (HP:0002149)2.38049371
103Cholelithiasis (HP:0001081)2.34998746
104Vomiting (HP:0002013)2.33237469
105Vascular calcification (HP:0004934)2.32631505
106Abnormal gallbladder morphology (HP:0012437)2.32552950
107Frequent falls (HP:0002359)2.32525833
108Generalized muscle weakness (HP:0003324)2.31434883
109Hyperglycemia (HP:0003074)2.28144432
110Calcaneovalgus deformity (HP:0001848)2.27174970
111Sensorimotor neuropathy (HP:0007141)2.23957278
112Steatorrhea (HP:0002570)2.22694316
113Renal cortical cysts (HP:0000803)2.19710930
114Neonatal onset (HP:0003623)2.18147196
115Lower limb amyotrophy (HP:0007210)2.15932320
116Pancreatitis (HP:0001733)2.15191454
117Exercise-induced myalgia (HP:0003738)2.15177892
118Spastic diplegia (HP:0001264)2.14323340
119Muscle stiffness (HP:0003552)2.13938717
120Cardiovascular calcification (HP:0011915)2.13696647
121Heart block (HP:0012722)2.07167955
122Right ventricular cardiomyopathy (HP:0011663)2.04924641
123Irritability (HP:0000737)2.04790440
124Paralysis (HP:0003470)2.03153058
125Malnutrition (HP:0004395)2.03019323
126Abnormal atrioventricular conduction (HP:0005150)2.01479266
127Nausea (HP:0002018)2.00011234
128Mitral stenosis (HP:0001718)1.99816772
129Abnormality of urine glucose concentration (HP:0011016)1.99777545
130Glycosuria (HP:0003076)1.99777545
131Enlarged kidneys (HP:0000105)1.99611444
132Epistaxis (HP:0000421)1.98616519
133Esophageal varix (HP:0002040)1.98505011
134Progressive external ophthalmoplegia (HP:0000590)1.98245296
135Scapular winging (HP:0003691)1.97009017
136Abnormal cartilage morphology (HP:0002763)1.95574266
137Purpura (HP:0000979)1.94264087
138Symptomatic seizures (HP:0011145)1.93128606
139Systemic lupus erythematosus (HP:0002725)1.92396755
140Hypochromic microcytic anemia (HP:0004840)1.91814924
141Abnormality of the fingertips (HP:0001211)1.91460879
142Poikilocytosis (HP:0004447)1.90758206
143Acanthocytosis (HP:0001927)1.89820017
144Spontaneous abortion (HP:0005268)1.89527392
145Abnormal gallbladder physiology (HP:0012438)1.89112897
146Cholecystitis (HP:0001082)1.89112897
147Fatigue (HP:0012378)1.86768405
148Alkalosis (HP:0001948)1.86050928
149Hypertriglyceridemia (HP:0002155)1.84672776
150Ragged-red muscle fibers (HP:0003200)1.83797680
151Brushfield spots (HP:0001088)1.82463057
152Abnormality of the gallbladder (HP:0005264)1.81759732
153Bulbar palsy (HP:0001283)1.81208451
154Deformed tarsal bones (HP:0008119)1.79239819
155Hemorrhage of the eye (HP:0011885)1.79024565
156Acute hepatic failure (HP:0006554)1.78305915
157Sudden death (HP:0001699)1.77064423
158Abnormality of the calcaneus (HP:0008364)1.76832794
159Atrioventricular block (HP:0001678)1.76711810
160Hepatic necrosis (HP:0002605)1.76701016
161Increased muscle lipid content (HP:0009058)1.71629872
162Exercise-induced muscle cramps (HP:0003710)1.70904616
163Ventricular arrhythmia (HP:0004308)1.67502494
164Testicular neoplasm (HP:0010788)1.65720748
165Absent phalangeal crease (HP:0006109)1.64968290
166Malignant hyperthermia (HP:0002047)1.64552338
167Abnormality of the foot musculature (HP:0001436)1.63946790
168Osteolytic defects of the hand bones (HP:0009699)1.63869718
169Osteolytic defects of the phalanges of the hand (HP:0009771)1.63869718
170Aortic aneurysm (HP:0004942)1.63551890
171Foot dorsiflexor weakness (HP:0009027)1.62399329
172Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62104532
173Ankyloglossia (HP:0010296)1.60494425
174Colitis (HP:0002583)1.60275262
175Spinal rigidity (HP:0003306)1.59448024
176Termporal pattern (HP:0011008)1.58168920
177Insidious onset (HP:0003587)1.58168920
178Diaphragmatic weakness (HP:0009113)1.57966424
179Abnormality of the Achilles tendon (HP:0005109)1.56459237
180Gowers sign (HP:0003391)1.55998139
181Petechiae (HP:0000967)1.54961919
182Neonatal hypoglycemia (HP:0001998)1.50707510
183Abnormal finger flexion creases (HP:0006143)1.50269491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.85494583
2SIK13.66120520
3TRIB33.27384274
4PKN22.99509307
5ERN12.97586174
6CDK122.89176633
7INSRR2.85040818
8FGFR42.82489462
9EEF2K2.49981385
10PDK32.45894821
11PDK42.45894821
12CAMK1D2.19338637
13TTN2.05884478
14TRPM71.97992488
15LMTK21.93406801
16TAOK31.88080356
17AKT31.80481912
18LATS11.70208533
19RIPK11.64490063
20MST1R1.62911251
21PINK11.61402419
22CAMK1G1.59664314
23FLT31.57760475
24OBSCN1.57742607
25WNK41.55410307
26MAP3K71.53885769
27PRPF4B1.53670808
28SCYL21.46424947
29PRKAA21.46391953
30PTK61.44816548
31FRK1.44608739
32PHKG11.39265844
33PHKG21.39265844
34MAP2K41.38828244
35PDK21.36942573
36STK241.36327350
37ERBB41.30672907
38MAPK111.23533841
39PIK3CG1.22288410
40NEK11.21391951
41NLK1.18860341
42TIE11.18217421
43STK31.13560636
44MST41.12393184
45PRKAA11.11771940
46NEK91.09476842
47JAK11.05281203
48TYK21.03244944
49FGFR21.01448458
50BRD41.00256839
51SGK30.98164114
52MAP2K30.98142876
53PIK3CA0.97795691
54EIF2AK10.96764116
55STK38L0.94034046
56JAK20.93397073
57DAPK20.91155605
58PDGFRA0.90218432
59MYLK0.88018291
60RIPK40.86505539
61MELK0.85498024
62STK40.85435124
63PDPK10.82885152
64ACVR1B0.80018975
65EPHB10.79959305
66WNK30.77941443
67TNIK0.77466712
68MAPK120.76791148
69MAP3K30.74408430
70PAK30.73382974
71PDGFRB0.71238151
72FGFR30.71236633
73EIF2AK30.69828322
74PRKACG0.69591949
75CDK40.68874422
76STK380.68822296
77SGK20.68584541
78MAP3K100.65934788
79LATS20.65210240
80TGFBR20.64514321
81RET0.64491546
82RPS6KB20.64458176
83PDK10.64096139
84KDR0.63491828
85PRKD10.63182439
86AKT20.62467554
87MAPKAPK30.61703146
88ABL20.61457011
89ERBB20.60704979
90MTOR0.59888802
91PRKCH0.58564418
92MET0.58106735
93SGK4940.57949631
94SGK2230.57949631
95MAPK100.57311872
96BTK0.55781781
97GSK3A0.54518944
98CAMK40.54459030
99CDK60.54106451
100MAP3K60.53216464
101ZAP700.52685479
102TEC0.52559375
103DYRK1B0.51033004
104PTK20.49391683
105ERBB30.48639369
106BMPR20.48589098
107MAP2K10.48476818
108ICK0.48193075
109RPS6KB10.46831586
110EPHA30.46252394
111CAMK2G0.46121254
112PRKCZ0.46058881
113TBK10.45831085
114SGK10.43546139
115FER0.43119236
116MAPK40.42047244
117MAP2K60.41858048
118OXSR10.41657204
119MAP3K130.41025014
120SMG10.38541560
121MAP3K140.38185411
122MARK20.37167031
123CSF1R0.36102494
124MAP3K50.35825223
125BRSK20.35016047
126CAMKK10.34435508
127BLK0.34024225
128MAPK70.33782961
129CHEK10.33575315
130PBK0.32580025
131RAF10.31999214
132IGF1R0.31813659
133MAP3K20.31776828
134WNK10.31014270
135IRAK30.30945162
136PRKD30.30073984
137DMPK0.29525835
138MAP3K10.27615069
139FGFR10.27353184
140KSR20.26159940
141RPS6KA30.26072435
142PRKACB0.25721223
143BMX0.24532749

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.65030259
2Nitrogen metabolism_Homo sapiens_hsa009103.40309579
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23575486
4Fatty acid degradation_Homo sapiens_hsa000713.16114542
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.96975019
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93250924
7Propanoate metabolism_Homo sapiens_hsa006402.86166328
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77278698
9Arginine biosynthesis_Homo sapiens_hsa002202.68616914
10Tryptophan metabolism_Homo sapiens_hsa003802.63065711
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53628467
12Butanoate metabolism_Homo sapiens_hsa006502.47723915
13Fatty acid metabolism_Homo sapiens_hsa012122.47067558
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35378350
15PPAR signaling pathway_Homo sapiens_hsa033202.23075069
16Peroxisome_Homo sapiens_hsa041462.08790386
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06140471
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06095362
19Complement and coagulation cascades_Homo sapiens_hsa046102.02776373
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01108747
21Platelet activation_Homo sapiens_hsa046111.85358396
22Pyruvate metabolism_Homo sapiens_hsa006201.82938424
23beta-Alanine metabolism_Homo sapiens_hsa004101.82496192
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68960903
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66310637
26Carbon metabolism_Homo sapiens_hsa012001.62343275
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56748711
28Bile secretion_Homo sapiens_hsa049761.52457963
29Thyroid cancer_Homo sapiens_hsa052161.51490617
30Histidine metabolism_Homo sapiens_hsa003401.48365036
31Fatty acid elongation_Homo sapiens_hsa000621.47545571
32Chemical carcinogenesis_Homo sapiens_hsa052041.45330890
33Starch and sucrose metabolism_Homo sapiens_hsa005001.44468326
34Caffeine metabolism_Homo sapiens_hsa002321.44266733
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41445444
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40118349
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.39376102
38Adherens junction_Homo sapiens_hsa045201.36753610
39Phenylalanine metabolism_Homo sapiens_hsa003601.36155122
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.32353867
41Sulfur metabolism_Homo sapiens_hsa009201.31892230
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31343276
43Selenocompound metabolism_Homo sapiens_hsa004501.31246239
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30401301
45Retinol metabolism_Homo sapiens_hsa008301.28560030
46Systemic lupus erythematosus_Homo sapiens_hsa053221.27643163
47ECM-receptor interaction_Homo sapiens_hsa045121.26616340
48Non-small cell lung cancer_Homo sapiens_hsa052231.24770074
49Biosynthesis of amino acids_Homo sapiens_hsa012301.22458997
50Fat digestion and absorption_Homo sapiens_hsa049751.20523204
51Tyrosine metabolism_Homo sapiens_hsa003501.20306576
52Endometrial cancer_Homo sapiens_hsa052131.19486803
53Focal adhesion_Homo sapiens_hsa045101.19237957
54ABC transporters_Homo sapiens_hsa020101.16890370
55Staphylococcus aureus infection_Homo sapiens_hsa051501.15600300
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14403298
57Lysine degradation_Homo sapiens_hsa003101.11646538
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08547503
59Fatty acid biosynthesis_Homo sapiens_hsa000611.08119658
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.03589575
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01830406
62Chronic myeloid leukemia_Homo sapiens_hsa052201.00901215
63Small cell lung cancer_Homo sapiens_hsa052220.99339251
64Inositol phosphate metabolism_Homo sapiens_hsa005620.97472086
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.96567851
66Pancreatic cancer_Homo sapiens_hsa052120.95561607
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95244593
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.93547098
69Glycerolipid metabolism_Homo sapiens_hsa005610.93243942
70Arginine and proline metabolism_Homo sapiens_hsa003300.91586377
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.86663127
72Folate biosynthesis_Homo sapiens_hsa007900.85659216
73mTOR signaling pathway_Homo sapiens_hsa041500.81493787
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80780558
75Vitamin digestion and absorption_Homo sapiens_hsa049770.80487947
76Acute myeloid leukemia_Homo sapiens_hsa052210.77364299
77FoxO signaling pathway_Homo sapiens_hsa040680.73273224
78Glioma_Homo sapiens_hsa052140.72899199
79Renal cell carcinoma_Homo sapiens_hsa052110.72621038
80Prostate cancer_Homo sapiens_hsa052150.72469553
81Proteoglycans in cancer_Homo sapiens_hsa052050.71679471
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70905540
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70446623
84B cell receptor signaling pathway_Homo sapiens_hsa046620.69842628
85Pancreatic secretion_Homo sapiens_hsa049720.67726259
86Sulfur relay system_Homo sapiens_hsa041220.64775219
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64636403
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64470477
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64383014
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63651795
91Tight junction_Homo sapiens_hsa045300.63647084
92Viral carcinogenesis_Homo sapiens_hsa052030.61552480
93Long-term potentiation_Homo sapiens_hsa047200.61222654
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.60416178
95Insulin resistance_Homo sapiens_hsa049310.59757998
96Steroid biosynthesis_Homo sapiens_hsa001000.59111519
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.58075904
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57201124
99Alcoholism_Homo sapiens_hsa050340.56944153
100Pentose phosphate pathway_Homo sapiens_hsa000300.55312216
101ErbB signaling pathway_Homo sapiens_hsa040120.55033501
102Vitamin B6 metabolism_Homo sapiens_hsa007500.54239095
103Choline metabolism in cancer_Homo sapiens_hsa052310.52307710
104Glutathione metabolism_Homo sapiens_hsa004800.49938343
105Oxytocin signaling pathway_Homo sapiens_hsa049210.48153593
106Glucagon signaling pathway_Homo sapiens_hsa049220.45860528
107Calcium signaling pathway_Homo sapiens_hsa040200.45155100
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44765880
109VEGF signaling pathway_Homo sapiens_hsa043700.43218684
110GnRH signaling pathway_Homo sapiens_hsa049120.43187080
111Fructose and mannose metabolism_Homo sapiens_hsa000510.42381985
112Galactose metabolism_Homo sapiens_hsa000520.42169900
113Metabolic pathways_Homo sapiens_hsa011000.41673707
114Renin secretion_Homo sapiens_hsa049240.40779275
115Gap junction_Homo sapiens_hsa045400.40736517
116AMPK signaling pathway_Homo sapiens_hsa041520.36394289
117One carbon pool by folate_Homo sapiens_hsa006700.26591091
118Insulin signaling pathway_Homo sapiens_hsa049100.24252137
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.19799682
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17057163
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16944927
122Prion diseases_Homo sapiens_hsa050200.12896692
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06912178
124Type II diabetes mellitus_Homo sapiens_hsa049300.06707762
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.05409905
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02646143
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01354385
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.00777702
129Amoebiasis_Homo sapiens_hsa05146-0.1315243
130Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1312306
131Circadian rhythm_Homo sapiens_hsa04710-0.1275343
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1094944
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0937753
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0904722
135Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0690315
136Cardiac muscle contraction_Homo sapiens_hsa04260-0.0479031
137Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0330567
138Renin-angiotensin system_Homo sapiens_hsa04614-0.0306263
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0228787
140Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0175922
141Linoleic acid metabolism_Homo sapiens_hsa00591-0.0109344
142Protein digestion and absorption_Homo sapiens_hsa04974-0.0045739
143Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0023671

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