VWA5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.04867661
2cell wall macromolecule catabolic process (GO:0016998)5.30921189
3positive regulation of prostaglandin secretion (GO:0032308)4.95385795
4regulation of interferon-beta biosynthetic process (GO:0045357)4.83744378
5neutrophil activation involved in immune response (GO:0002283)4.65439758
6positive regulation by symbiont of host defense response (GO:0052509)4.64588755
7modulation by symbiont of host defense response (GO:0052031)4.64588755
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.64588755
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.64588755
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.64588755
11modulation by symbiont of host immune response (GO:0052553)4.64588755
12positive regulation of heat generation (GO:0031652)4.63695873
13positive regulation of interferon-alpha production (GO:0032727)4.43869555
14regulation of fever generation (GO:0031620)4.41285692
15cell wall macromolecule metabolic process (GO:0044036)4.35154419
16regulation of prostaglandin secretion (GO:0032306)4.32874481
17regulation of cilium movement (GO:0003352)4.19020542
18regulation of interferon-alpha production (GO:0032647)4.17548844
19positive regulation of osteoclast differentiation (GO:0045672)4.13628524
20antigen processing and presentation of endogenous antigen (GO:0019883)4.04112503
21positive regulation of antigen processing and presentation (GO:0002579)4.03758827
22macrophage activation involved in immune response (GO:0002281)4.01596183
23regulation of memory T cell differentiation (GO:0043380)3.99726615
24response to lipoprotein particle (GO:0055094)3.96691318
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91021050
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.91021050
27production of molecular mediator involved in inflammatory response (GO:0002532)3.88448487
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.86542665
29negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.82944245
30positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.77387966
31regulation of heat generation (GO:0031650)3.75165089
32adenosine metabolic process (GO:0046085)3.75135617
33positive regulation of icosanoid secretion (GO:0032305)3.68247900
34magnesium ion transport (GO:0015693)3.61840309
35cullin deneddylation (GO:0010388)3.57500772
36immunoglobulin mediated immune response (GO:0016064)3.55612093
37positive regulation of fatty acid transport (GO:2000193)3.50263097
38protein deneddylation (GO:0000338)3.48074072
39regulation of antigen processing and presentation (GO:0002577)3.34688747
40sleep (GO:0030431)3.34628333
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31412644
42response to host immune response (GO:0052572)3.31412644
43cellular ketone body metabolic process (GO:0046950)3.29035690
44positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.19966251
45epithelial cilium movement (GO:0003351)3.19955669
46response to type I interferon (GO:0034340)3.18178302
47type I interferon signaling pathway (GO:0060337)3.15318317
48cellular response to type I interferon (GO:0071357)3.15318317
49axoneme assembly (GO:0035082)3.14349072
50positive regulation of natural killer cell differentiation (GO:0032825)3.14322020
51negative regulation of interleukin-17 production (GO:0032700)3.13774081
52response to interferon-alpha (GO:0035455)3.12859039
53microglial cell activation (GO:0001774)3.12389736
54protein localization to cilium (GO:0061512)3.12371367
55detection of other organism (GO:0098543)3.09979766
56neutrophil activation (GO:0042119)3.07641636
57granulocyte activation (GO:0036230)3.06411855
58respiratory burst (GO:0045730)3.06131107
59T-helper 1 type immune response (GO:0042088)3.02713812
60regulation of microtubule-based movement (GO:0060632)3.02057439
61myeloid cell activation involved in immune response (GO:0002275)3.01585061
62positive regulation of monocyte chemotaxis (GO:0090026)3.00585388
63macrophage activation (GO:0042116)2.96184167
64positive regulation of interferon-beta production (GO:0032728)2.95320155
65cilium movement (GO:0003341)2.95194074
66regulation of icosanoid secretion (GO:0032303)2.94097265
67platelet dense granule organization (GO:0060155)2.93251129
68response to host (GO:0075136)2.92482113
69response to host defenses (GO:0052200)2.92482113
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92482113
71response to peptidoglycan (GO:0032494)2.91551125
72positive regulation of macrophage cytokine production (GO:0060907)2.90188005
73regulation of hypersensitivity (GO:0002883)2.89354116
74regulation of cholesterol storage (GO:0010885)2.88564281
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88465979
76regulation of activation of Janus kinase activity (GO:0010533)2.87719924
77macroautophagy (GO:0016236)2.86938731
78regulation of interleukin-12 biosynthetic process (GO:0045075)2.86274965
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85776980
80detection of molecule of bacterial origin (GO:0032490)2.85356770
81positive regulation of mast cell activation (GO:0033005)2.85042045
82positive regulation of mast cell degranulation (GO:0043306)2.85012880
83positive regulation of mast cell activation involved in immune response (GO:0033008)2.85012880
84cell adhesion mediated by integrin (GO:0033627)2.84841507
85positive regulation of macrophage differentiation (GO:0045651)2.84548937
86phenylpropanoid metabolic process (GO:0009698)2.82986201
87ketone body metabolic process (GO:1902224)2.82733784
88axonemal dynein complex assembly (GO:0070286)2.81698025
89interferon-gamma-mediated signaling pathway (GO:0060333)2.80672053
90positive regulation of cellular amide metabolic process (GO:0034250)2.80640453
91GPI anchor metabolic process (GO:0006505)2.80527348
92positive regulation of B cell differentiation (GO:0045579)2.78613106
93brain morphogenesis (GO:0048854)2.78436274
94regulation of interleukin-8 biosynthetic process (GO:0045414)2.78109583
95positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77430506
96pinocytosis (GO:0006907)2.76671277
97glycosphingolipid biosynthetic process (GO:0006688)2.75828281
98regulation of monocyte chemotaxis (GO:0090025)2.75627373
99nucleobase catabolic process (GO:0046113)2.74911697
100pigment granule transport (GO:0051904)2.74575017
101female gonad development (GO:0008585)2.74515279
102nonmotile primary cilium assembly (GO:0035058)2.73902107
103positive regulation of leukocyte degranulation (GO:0043302)2.73374457
104positive regulation of gamma-delta T cell activation (GO:0046645)2.72580875
105preassembly of GPI anchor in ER membrane (GO:0016254)2.70380346
106natural killer cell mediated cytotoxicity (GO:0042267)2.69832778
107natural killer cell mediated immunity (GO:0002228)2.69832778
108positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.69233785
109photoreceptor cell maintenance (GO:0045494)2.68215195
110monocyte chemotaxis (GO:0002548)2.68095634
111myelin assembly (GO:0032288)2.65169734
112regulation of immunoglobulin secretion (GO:0051023)2.64615859
113establishment of pigment granule localization (GO:0051905)2.64204771
114regulation of mononuclear cell migration (GO:0071675)2.63961313
115GPI anchor biosynthetic process (GO:0006506)2.63752794
116cilium or flagellum-dependent cell motility (GO:0001539)2.63505972
117positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.63105568
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62093262
119regulation of mast cell degranulation (GO:0043304)2.61781157
120cellular response to interferon-alpha (GO:0035457)2.60258900
121antigen processing and presentation via MHC class Ib (GO:0002475)2.59098093
122protein polyglutamylation (GO:0018095)2.58443774
123detection of external biotic stimulus (GO:0098581)2.58045455
124melanosome transport (GO:0032402)2.58033279
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57383740
126I-kappaB phosphorylation (GO:0007252)2.57326002
127glycerophospholipid catabolic process (GO:0046475)2.57038774
128arginine metabolic process (GO:0006525)2.55560839
129glycolipid biosynthetic process (GO:0009247)2.55477911
130dendritic cell differentiation (GO:0097028)2.55016098
131response to interferon-beta (GO:0035456)2.54920456
132low-density lipoprotein particle clearance (GO:0034383)2.54082530
133regulation of mast cell activation involved in immune response (GO:0033006)2.54070856
134cellular response to thyroid hormone stimulus (GO:0097067)2.53607931
135positive regulation of T cell cytokine production (GO:0002726)2.53225435
136apoptotic cell clearance (GO:0043277)2.53169450
137phospholipid homeostasis (GO:0055091)2.53039892
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52877833
139B cell mediated immunity (GO:0019724)2.52316629
140one-carbon compound transport (GO:0019755)2.52285254
141positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.52048145
142regulation of macrophage cytokine production (GO:0010935)2.51260702
143hydrogen peroxide biosynthetic process (GO:0050665)2.50599504
144myeloid dendritic cell differentiation (GO:0043011)2.50308602
145positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.49184897
146pigment granule localization (GO:0051875)2.49051777
147positive regulation of cholesterol transport (GO:0032376)2.48904818
148positive regulation of sterol transport (GO:0032373)2.48904818
149regulation of T-helper 1 cell differentiation (GO:0045625)2.48374048
150establishment of melanosome localization (GO:0032401)2.47943554
151neurotransmitter biosynthetic process (GO:0042136)2.47916407
152L-fucose catabolic process (GO:0042355)2.47483299
153fucose catabolic process (GO:0019317)2.47483299
154L-fucose metabolic process (GO:0042354)2.47483299
1553-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.47325264
156purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.47325264
157negative regulation of lipid storage (GO:0010888)2.47057409
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.44172103
159branched-chain amino acid catabolic process (GO:0009083)2.43737717
160cytokine secretion (GO:0050663)2.43697377
161positive regulation of organic acid transport (GO:0032892)2.43376345
162regulation of mast cell activation (GO:0033003)2.43160568
163ATP hydrolysis coupled proton transport (GO:0015991)2.42176872
164energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.42176872
165JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.41993376
166myeloid leukocyte activation (GO:0002274)2.41837953
167cellular response to leptin stimulus (GO:0044320)2.40856676
168positive regulation of interleukin-12 production (GO:0032735)2.39931395
169male sex determination (GO:0030238)2.39707945
170regulation of B cell receptor signaling pathway (GO:0050855)2.39029102
171indolalkylamine metabolic process (GO:0006586)2.38235692
172cilium morphogenesis (GO:0060271)2.37308778
173positive regulation of acute inflammatory response (GO:0002675)2.36512644
174actin nucleation (GO:0045010)2.35462281
175negative regulation of appetite (GO:0032099)2.35427664
176negative regulation of response to food (GO:0032096)2.35427664
177positive regulation of tumor necrosis factor production (GO:0032760)2.34688695
178melanosome localization (GO:0032400)2.33514287
179interleukin-1-mediated signaling pathway (GO:0070498)2.32703334
180retinol metabolic process (GO:0042572)2.32482026
181amyloid precursor protein catabolic process (GO:0042987)2.31934367
182response to leptin (GO:0044321)2.28439038
183sialylation (GO:0097503)2.28302791
184epoxygenase P450 pathway (GO:0019373)2.28162039
185regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.27606554
186primary amino compound metabolic process (GO:1901160)2.27230627
187C-terminal protein lipidation (GO:0006501)2.26926188
188nitric oxide mediated signal transduction (GO:0007263)2.24128573
189reverse cholesterol transport (GO:0043691)2.23803892
190positive regulation of oligodendrocyte differentiation (GO:0048714)2.23028754
191regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.22739728
192positive regulation of cholesterol efflux (GO:0010875)2.22347962
193short-chain fatty acid metabolic process (GO:0046459)2.21674451
194fat-soluble vitamin biosynthetic process (GO:0042362)2.20826121
195eosinophil chemotaxis (GO:0048245)2.20462924
196cilium assembly (GO:0042384)2.18455642
197cilium organization (GO:0044782)2.17203472
198negative regulation of cytosolic calcium ion concentration (GO:0051481)2.16549073
199positive regulation of bone resorption (GO:0045780)2.16327862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.74918514
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.09072582
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.28859005
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.68681331
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.68031716
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42252982
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.39123919
8GBX2_23144817_ChIP-Seq_PC3_Human3.29857481
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.29318177
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20689117
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.97779922
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93022627
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65511621
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64917157
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63335863
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56540926
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51662780
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50173684
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44458886
20ZNF274_21170338_ChIP-Seq_K562_Hela2.40416118
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.28324979
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28141580
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26039719
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23747126
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.23223459
26PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07215545
27TAF15_26573619_Chip-Seq_HEK293_Human2.01960594
28GATA2_21666600_ChIP-Seq_HMVEC_Human2.01877231
29* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00375885
30GATA1_22025678_ChIP-Seq_K562_Human1.99987129
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87445025
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87047486
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85127212
34RUNX_20019798_ChIP-Seq_JUKART_Human1.80376509
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79631777
36P300_19829295_ChIP-Seq_ESCs_Human1.76157047
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75803068
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74186700
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74116947
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73038488
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69704897
42CBP_20019798_ChIP-Seq_JUKART_Human1.66065599
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66065599
44VDR_22108803_ChIP-Seq_LS180_Human1.65905508
45VDR_24787735_ChIP-Seq_THP-1_Human1.65791578
46SPI1_23127762_ChIP-Seq_K562_Human1.65702300
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.65608741
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65590239
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65063636
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64405952
51IGF1R_20145208_ChIP-Seq_DFB_Human1.63916783
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63878239
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62152740
54SMAD4_21799915_ChIP-Seq_A2780_Human1.61082400
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59701978
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57167883
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.56457184
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55989996
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54694227
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54580306
61* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51936240
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.51788861
63CDX2_22108803_ChIP-Seq_LS180_Human1.51778921
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47594475
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47280449
66FUS_26573619_Chip-Seq_HEK293_Human1.46004998
67CLOCK_20551151_ChIP-Seq_293T_Human1.45146863
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44613258
69SOX2_20726797_ChIP-Seq_SW620_Human1.44591434
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.43199793
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42945820
72PU_27001747_Chip-Seq_BMDM_Mouse1.42899950
73SPI1_23547873_ChIP-Seq_NB4_Human1.42797569
74AR_25329375_ChIP-Seq_VCAP_Human1.42302806
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41921015
76EZH2_22144423_ChIP-Seq_EOC_Human1.41234107
77SCL_19346495_ChIP-Seq_HPC-7_Human1.41189221
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40073781
79VDR_24763502_ChIP-Seq_THP-1_Human1.39270116
80TP53_22573176_ChIP-Seq_HFKS_Human1.38909657
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38611891
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38611891
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37664335
84CJUN_26792858_Chip-Seq_BT549_Human1.37196626
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.36622461
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.36158901
87* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35924397
88LXR_22158963_ChIP-Seq_LIVER_Mouse1.35788144
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.35283810
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34616356
91STAT3_23295773_ChIP-Seq_U87_Human1.33821609
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33440926
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33335526
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.32860427
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.32857337
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30735655
97MYB_26560356_Chip-Seq_TH2_Human1.30079629
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29784569
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29702454
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29143242
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29080647
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28862734
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.28256599
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27929732
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26898532
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26439690
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26439690
108TCF4_23295773_ChIP-Seq_U87_Human1.26073588
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.25988558
110BCAT_22108803_ChIP-Seq_LS180_Human1.24928009
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.24446833
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24446833
113NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24105253
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22441626
115* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22394020
116MAF_26560356_Chip-Seq_TH1_Human1.21291445
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21189974
118PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20943913
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.20799259
120EGR1_19032775_ChIP-ChIP_M12_Human1.20465589
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20045995
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19953624
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19861625
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19660663
125P53_22387025_ChIP-Seq_ESCs_Mouse1.19629567
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19177781
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.19065614
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18754454
129NANOG_19829295_ChIP-Seq_ESCs_Human1.18346610
130SOX2_19829295_ChIP-Seq_ESCs_Human1.18346610
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.15795771
132RUNX2_22187159_ChIP-Seq_PCA_Human1.15607922
133ELK3_25401928_ChIP-Seq_HUVEC_Human1.15520759
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14956619
135AR_20517297_ChIP-Seq_VCAP_Human1.14153992
136PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13870515
137* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13213112
138ER_23166858_ChIP-Seq_MCF-7_Human1.13131302
139* TCF4_22108803_ChIP-Seq_LS180_Human1.12793359
140REST_21632747_ChIP-Seq_MESCs_Mouse1.11835740
141IRF1_19129219_ChIP-ChIP_H3396_Human1.10408772
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08647179
143SALL1_21062744_ChIP-ChIP_HESCs_Human1.07866094
144CMYC_18555785_Chip-Seq_ESCs_Mouse1.07523913
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07431793
146SMAD_19615063_ChIP-ChIP_OVARY_Human1.07214401
147KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07143065
148SOX2_18555785_Chip-Seq_ESCs_Mouse1.07028699
149EWS_26573619_Chip-Seq_HEK293_Human1.06897610
150NCOR_22424771_ChIP-Seq_293T_Human1.06656501
151OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06485976
152E2F1_18555785_Chip-Seq_ESCs_Mouse1.06190038
153SMAD3_21741376_ChIP-Seq_HESCs_Human1.05913564
154HTT_18923047_ChIP-ChIP_STHdh_Human1.05863037
155SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05317615
156FLI1_21867929_ChIP-Seq_TH2_Mouse1.05184324
157ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05123133
158JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04572300
159SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04533043
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04466763
161JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03918462
162RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03302917
163SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03073342
164P300_18555785_Chip-Seq_ESCs_Mouse1.03007270
165TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01767309
166TAL1_26923725_Chip-Seq_HPCs_Mouse1.01721219
167SOX2_21211035_ChIP-Seq_LN229_Gbm1.01154967
168MYB_26560356_Chip-Seq_TH1_Human1.00708848
169DROSHA_22980978_ChIP-Seq_HELA_Human1.00046026
170OCT4_18555785_Chip-Seq_ESCs_Mouse0.99797149
171WT1_19549856_ChIP-ChIP_CCG9911_Human0.99580227
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99433228
173CBX2_27304074_Chip-Seq_ESCs_Mouse0.99082477
174CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98841030
175GATA3_26560356_Chip-Seq_TH2_Human0.98648653
176CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98636081
177BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98433881
178SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98281153
179* SMAD4_21741376_ChIP-Seq_EPCs_Human0.97935800
180ESR1_20079471_ChIP-ChIP_T-47D_Human0.97863159
181CTCF_18555785_Chip-Seq_ESCs_Mouse0.97744509
182EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97633171
183LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95518044
184SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94975137
185GATA3_27048872_Chip-Seq_THYMUS_Human0.94815902
186LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92677557
187GATA1_19941826_ChIP-Seq_K562_Human0.91483666
188P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91387631
189* GATA2_19941826_ChIP-Seq_K562_Human0.91251857
190KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90651494
191ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89428176
192VDR_21846776_ChIP-Seq_THP-1_Human0.89104791
193EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86916633
194FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86900257
195SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86689168
196GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84386325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.81884926
2MP0005058_abnormal_lysosome_morphology3.48255242
3MP0001984_abnormal_olfaction3.10794871
4MP0002876_abnormal_thyroid_physiology3.10562661
5MP0009780_abnormal_chondrocyte_physiolo3.02783699
6MP0003436_decreased_susceptibility_to2.90690866
7MP0010234_abnormal_vibrissa_follicle2.70421623
8MP0003191_abnormal_cellular_cholesterol2.63792188
9MP0002148_abnormal_hypersensitivity_rea2.60423638
10MP0006082_CNS_inflammation2.57452378
11MP0002419_abnormal_innate_immunity2.47966689
12MP0003724_increased_susceptibility_to2.42150097
13MP0008438_abnormal_cutaneous_collagen2.40681584
14MP0009785_altered_susceptibility_to2.39924774
15MP0003300_gastrointestinal_ulcer2.29843181
16MP0000685_abnormal_immune_system2.29036928
17MP0005387_immune_system_phenotype2.24961889
18MP0001790_abnormal_immune_system2.24961889
19MP0005000_abnormal_immune_tolerance2.24713751
20MP0003172_abnormal_lysosome_physiology2.14840408
21MP0005025_abnormal_response_to2.13593387
22MP0004885_abnormal_endolymph2.13561652
23MP0002909_abnormal_adrenal_gland2.10336820
24MP0009840_abnormal_foam_cell1.98605375
25MP0002254_reproductive_system_inflammat1.98361545
26MP0001533_abnormal_skeleton_physiology1.95119503
27MP0005464_abnormal_platelet_physiology1.93645943
28MP0005365_abnormal_bile_salt1.91310553
29MP0005551_abnormal_eye_electrophysiolog1.90933858
30MP0002452_abnormal_antigen_presenting1.89492167
31MP0002166_altered_tumor_susceptibility1.85474130
32MP0009278_abnormal_bone_marrow1.85411663
33MP0003303_peritoneal_inflammation1.84902745
34MP0001188_hyperpigmentation1.83890434
35MP0001501_abnormal_sleep_pattern1.83771293
36MP0006072_abnormal_retinal_apoptosis1.83455016
37MP0005671_abnormal_response_to1.81748254
38MP0002139_abnormal_hepatobiliary_system1.80583789
39MP0000013_abnormal_adipose_tissue1.78240100
40MP0005645_abnormal_hypothalamus_physiol1.77996597
41MP0004510_myositis1.75558391
42MP0003011_delayed_dark_adaptation1.73928140
43MP0002723_abnormal_immune_serum1.73922487
44MP0001800_abnormal_humoral_immune1.71669025
45MP0003880_abnormal_central_pattern1.69610046
46MP0004019_abnormal_vitamin_homeostasis1.66616493
47MP0008789_abnormal_olfactory_epithelium1.65973035
48MP0010386_abnormal_urinary_bladder1.65600186
49MP0008875_abnormal_xenobiotic_pharmacok1.65477594
50MP0005394_taste/olfaction_phenotype1.63539654
51MP0005499_abnormal_olfactory_system1.63539654
52MP0001502_abnormal_circadian_rhythm1.63237188
53MP0000343_altered_response_to1.61868576
54MP0004947_skin_inflammation1.61280965
55MP0003566_abnormal_cell_adhesion1.59285407
56MP0005332_abnormal_amino_acid1.57830303
57MP0000569_abnormal_digit_pigmentation1.55962109
58MP0005646_abnormal_pituitary_gland1.55949383
59MP0002006_tumorigenesis1.54956864
60MP0003879_abnormal_hair_cell1.54490130
61MP0003705_abnormal_hypodermis_morpholog1.54211647
62MP0001819_abnormal_immune_cell1.52712451
63MP0009764_decreased_sensitivity_to1.51468452
64MP0000604_amyloidosis1.50915346
65MP0002420_abnormal_adaptive_immunity1.50249850
66MP0010329_abnormal_lipoprotein_level1.49487420
67MP0001853_heart_inflammation1.49196287
68MP0001845_abnormal_inflammatory_respons1.46974769
69MP0002837_dystrophic_cardiac_calcinosis1.46934738
70MP0003183_abnormal_peptide_metabolism1.45699740
71MP0002405_respiratory_system_inflammati1.44605797
72MP0001958_emphysema1.44120145
73MP0005275_abnormal_skin_tensile1.44079574
74MP0002998_abnormal_bone_remodeling1.43820704
75MP0004043_abnormal_pH_regulation1.42819716
76MP0005253_abnormal_eye_physiology1.40342810
77MP0001756_abnormal_urination1.39805589
78MP0001765_abnormal_ion_homeostasis1.39408826
79MP0008877_abnormal_DNA_methylation1.38932176
80MP0003448_altered_tumor_morphology1.38669891
81MP0003690_abnormal_glial_cell1.38567113
82MP0003279_aneurysm1.37205660
83MP0008469_abnormal_protein_level1.36906831
84MP0004270_analgesia1.35938715
85MP0005310_abnormal_salivary_gland1.32003318
86MP0002557_abnormal_social/conspecific_i1.31207277
87MP0003122_maternal_imprinting1.31034605
88MP0008872_abnormal_physiological_respon1.30244705
89MP0002736_abnormal_nociception_after1.27195213
90MP0005636_abnormal_mineral_homeostasis1.26990356
91MP0002272_abnormal_nervous_system1.26875434
92MP0002138_abnormal_hepatobiliary_system1.24667798
93MP0006276_abnormal_autonomic_nervous1.23524061
94MP0005397_hematopoietic_system_phenotyp1.22972343
95MP0001545_abnormal_hematopoietic_system1.22972343
96MP0003075_altered_response_to1.22783551
97MP0001666_abnormal_nutrient_absorption1.22048133
98MP0009046_muscle_twitch1.21830150
99MP0002102_abnormal_ear_morphology1.21221952
100MP0010155_abnormal_intestine_physiology1.20442845
101MP0005085_abnormal_gallbladder_physiolo1.20296490
102MP0003045_fibrosis1.16677491
103MP0002877_abnormal_melanocyte_morpholog1.16096688
104MP0003091_abnormal_cell_migration1.16071877
105MP0000230_abnormal_systemic_arterial1.15537318
106MP0001905_abnormal_dopamine_level1.14892860
107MP0004858_abnormal_nervous_system1.14421521
108MP0005410_abnormal_fertilization1.11844650
109MP0000858_altered_metastatic_potential1.11794172
110MP0010307_abnormal_tumor_latency1.11593674
111MP0005360_urolithiasis1.11133097
112MP0003787_abnormal_imprinting1.10289516
113MP0000465_gastrointestinal_hemorrhage1.09215251
114MP0001664_abnormal_digestion1.07440024
115MP0001968_abnormal_touch/_nociception1.07227058
116MP0005164_abnormal_response_to1.06512452
117MP0010678_abnormal_skin_adnexa1.06400565
118MP0003828_pulmonary_edema1.06176060
119MP0000716_abnormal_immune_system1.04609362
120MP0002638_abnormal_pupillary_reflex1.04349880
121MP0005166_decreased_susceptibility_to1.03985977
122MP0002822_catalepsy1.03599611
123MP0005386_behavior/neurological_phenoty1.03350861
124MP0004924_abnormal_behavior1.03350861
125MP0005084_abnormal_gallbladder_morpholo1.02442829
126MP0002229_neurodegeneration1.02326680
127MP0001873_stomach_inflammation1.02099029
128MP0001348_abnormal_lacrimal_gland1.01585385
129MP0005448_abnormal_energy_balance1.01164041
130MP0001970_abnormal_pain_threshold0.99494732
131MP0004130_abnormal_muscle_cell0.99298219
132MP0004133_heterotaxia0.99129649
133MP0003656_abnormal_erythrocyte_physiolo0.99041470
134MP0002734_abnormal_mechanical_nocicepti0.98871407
135MP0001851_eye_inflammation0.97468157
136MP0002572_abnormal_emotion/affect_behav0.97249539
137MP0005390_skeleton_phenotype0.97011901
138MP0000249_abnormal_blood_vessel0.96190029
139MP0005023_abnormal_wound_healing0.95565390
140MP0004883_abnormal_blood_vessel0.95437605
141MP0005535_abnormal_body_temperature0.93261304
142MP0002933_joint_inflammation0.92706168
143MP0002069_abnormal_eating/drinking_beha0.92491369
144MP0001529_abnormal_vocalization0.90253297
145MP0005174_abnormal_tail_pigmentation0.89735870
146MP0002064_seizures0.89376763
147MP0002398_abnormal_bone_marrow0.89350439
148MP0000538_abnormal_urinary_bladder0.88528023
149MP0001764_abnormal_homeostasis0.88309826
150MP0002095_abnormal_skin_pigmentation0.88254672
151MP0001542_abnormal_bone_strength0.88234062
152MP0009745_abnormal_behavioral_response0.87492867
153MP0002118_abnormal_lipid_homeostasis0.86793639
154MP0008775_abnormal_heart_ventricle0.85432875
155MP0000639_abnormal_adrenal_gland0.85252261
156MP0003195_calcinosis0.85246657
157MP0004215_abnormal_myocardial_fiber0.84156651
158MP0000767_abnormal_smooth_muscle0.83098593
159MP0004147_increased_porphyrin_level0.82326910
160MP0003795_abnormal_bone_structure0.81989040
161MP0003878_abnormal_ear_physiology0.81683591
162MP0005377_hearing/vestibular/ear_phenot0.81683591
163MP0000689_abnormal_spleen_morphology0.81224202
164MP0009763_increased_sensitivity_to0.80767699
165MP0005379_endocrine/exocrine_gland_phen0.80758947
166MP0002429_abnormal_blood_cell0.80758636
167MP0005075_abnormal_melanosome_morpholog0.79857819
168MP0003638_abnormal_response/metabolism_0.79118695
169MP0002693_abnormal_pancreas_physiology0.78760084
170MP0000566_synostosis0.78667038
171MP0004742_abnormal_vestibular_system0.78332847
172MP0002938_white_spotting0.77899338
173MP0003453_abnormal_keratinocyte_physiol0.77665528
174MP0004782_abnormal_surfactant_physiolog0.77536840
175MP0005167_abnormal_blood-brain_barrier0.77090878
176MP0009333_abnormal_splenocyte_physiolog0.76638366
177MP0005670_abnormal_white_adipose0.75805346
178MP0002735_abnormal_chemical_nociception0.73028462
179MP0002136_abnormal_kidney_physiology0.72987906
180MP0002722_abnormal_immune_system0.72948328
181MP0002295_abnormal_pulmonary_circulatio0.72860710
182MP0005257_abnormal_intraocular_pressure0.72815215
183MP0004272_abnormal_basement_membrane0.69693079
184MP0006054_spinal_hemorrhage0.69664076
185MP0000609_abnormal_liver_physiology0.69651848

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.22327637
2Recurrent abscess formation (HP:0002722)5.17035787
3Systemic lupus erythematosus (HP:0002725)4.76136099
4Increased cerebral lipofuscin (HP:0011813)4.55350658
5Recurrent bacterial skin infections (HP:0005406)4.51886784
6Vacuolated lymphocytes (HP:0001922)4.27458775
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.02378534
8Axonal loss (HP:0003447)3.89676940
9Recurrent gram-negative bacterial infections (HP:0005420)3.85180529
10Abnormality of macrophages (HP:0004311)3.70447086
11Dysostosis multiplex (HP:0000943)3.65046273
12Medial flaring of the eyebrow (HP:0010747)3.61523953
13Rhinitis (HP:0012384)3.61508406
14Myocardial infarction (HP:0001658)3.48675672
15Myositis (HP:0100614)3.48425281
16Orchitis (HP:0100796)3.40498377
17Glomerulonephritis (HP:0000099)3.39167229
18Gait imbalance (HP:0002141)3.26242285
19Congenital primary aphakia (HP:0007707)3.16640490
20Autoimmune thrombocytopenia (HP:0001973)3.15740436
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.15521800
22Osteolytic defects of the hand bones (HP:0009699)3.15521800
23Mucopolysacchariduria (HP:0008155)3.14104980
24Urinary glycosaminoglycan excretion (HP:0003541)3.14104980
25Abnormality of liposaccharide metabolism (HP:0010968)3.05440540
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.05440540
27Abnormality of glycolipid metabolism (HP:0010969)3.05440540
28Optic neuritis (HP:0100653)3.03584411
29Retrobulbar optic neuritis (HP:0100654)3.03584411
30Abnormal respiratory motile cilium morphology (HP:0005938)3.01561408
31Abnormal respiratory epithelium morphology (HP:0012253)3.01561408
32Hematochezia (HP:0002573)3.01073734
33Interstitial pulmonary disease (HP:0006530)2.96139030
34Nephrogenic diabetes insipidus (HP:0009806)2.96094253
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.92558400
36Abnormality of polysaccharide metabolism (HP:0011012)2.92558400
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.92558400
38Abnormality of vitamin B metabolism (HP:0004340)2.86603851
39Increased density of long bones (HP:0006392)2.86282788
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.85600974
41Thick nail (HP:0001805)2.85127951
42Abnormality of the renal cortex (HP:0011035)2.85096943
43Elevated erythrocyte sedimentation rate (HP:0003565)2.84357553
44Polyphagia (HP:0002591)2.81414505
45Hyperglycinemia (HP:0002154)2.78164454
46Molar tooth sign on MRI (HP:0002419)2.78142856
47Abnormality of midbrain morphology (HP:0002418)2.78142856
48Methylmalonic aciduria (HP:0012120)2.77826650
49Recurrent skin infections (HP:0001581)2.77327974
50Methylmalonic acidemia (HP:0002912)2.75113398
51Intestinal atresia (HP:0011100)2.74749672
52Complement deficiency (HP:0004431)2.74185571
53Nephritis (HP:0000123)2.73913825
54Vertebral compression fractures (HP:0002953)2.72722093
55Gingivitis (HP:0000230)2.69582666
56Mediastinal lymphadenopathy (HP:0100721)2.68249557
57Abnormal ciliary motility (HP:0012262)2.66493602
58Tetraparesis (HP:0002273)2.66030405
59Congenital sensorineural hearing impairment (HP:0008527)2.65456119
60Abnormality of complement system (HP:0005339)2.63403149
61Hypothermia (HP:0002045)2.61067119
62Periodontitis (HP:0000704)2.59424915
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57793729
64Thyroiditis (HP:0100646)2.55742139
65Hypokinesia (HP:0002375)2.55002525
66Disinhibition (HP:0000734)2.54543478
67Renal cortical cysts (HP:0000803)2.52680708
68Pancreatic cysts (HP:0001737)2.51032973
69Recurrent fungal infections (HP:0002841)2.50591251
70Type II lissencephaly (HP:0007260)2.50290983
71Abnormal respiratory motile cilium physiology (HP:0012261)2.50002010
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.48463528
73Absent/shortened dynein arms (HP:0200106)2.48463528
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48414898
75Abnormality of vitamin metabolism (HP:0100508)2.47502418
76Agitation (HP:0000713)2.46793939
77Arterial thrombosis (HP:0004420)2.46656722
78Petechiae (HP:0000967)2.42149658
79Pathologic fracture (HP:0002756)2.40524217
80Loss of speech (HP:0002371)2.39933637
81Decreased circulating renin level (HP:0003351)2.38644434
82Hyperaldosteronism (HP:0000859)2.37858311
83Segmental peripheral demyelination/remyelination (HP:0003481)2.36419362
84Nephronophthisis (HP:0000090)2.36394135
85Large for gestational age (HP:0001520)2.35776824
86Vasculitis (HP:0002633)2.33597109
87Chronic otitis media (HP:0000389)2.32832419
88Osteomyelitis (HP:0002754)2.31697879
89Genital tract atresia (HP:0001827)2.31371204
90Epidermoid cyst (HP:0200040)2.31228873
91Abnormality of the vitamin B12 metabolism (HP:0004341)2.30739892
92Hyperphosphaturia (HP:0003109)2.29554003
93Ketoacidosis (HP:0001993)2.28949202
94Vaginal atresia (HP:0000148)2.28774087
95Spontaneous hematomas (HP:0007420)2.28535706
96Prostate neoplasm (HP:0100787)2.27804921
97Cellulitis (HP:0100658)2.25861001
98Ketosis (HP:0001946)2.25846828
99Poor coordination (HP:0002370)2.24636934
100Ulnar claw (HP:0001178)2.24580660
101Glycosuria (HP:0003076)2.23822052
102Abnormality of urine glucose concentration (HP:0011016)2.23822052
103Limb dystonia (HP:0002451)2.23619165
104Basal ganglia calcification (HP:0002135)2.22792268
105Chronic hepatic failure (HP:0100626)2.21724942
106Renal Fanconi syndrome (HP:0001994)2.20419042
107Gingival bleeding (HP:0000225)2.18929110
108Colitis (HP:0002583)2.18305803
109Gonadal dysgenesis (HP:0000133)2.13808122
110Hypophosphatemia (HP:0002148)2.13353832
111Increased CSF protein (HP:0002922)2.12928790
112Recurrent viral infections (HP:0004429)2.12707087
113Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12692710
114Abnormality of the lumbar spine (HP:0100712)2.12578368
115Retinal dysplasia (HP:0007973)2.11880853
116Pulmonary infiltrates (HP:0002113)2.11133302
117Metabolic acidosis (HP:0001942)2.10561628
118Asymmetric septal hypertrophy (HP:0001670)2.08825974
119Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08425486
120Peripheral demyelination (HP:0011096)2.07530554
121Cervical subluxation (HP:0003308)2.07500504
122Cerebellar dysplasia (HP:0007033)2.06817550
123Pancreatic fibrosis (HP:0100732)2.06594121
124Esophageal varix (HP:0002040)2.06587073
125Hepatosplenomegaly (HP:0001433)2.05926484
126Severe combined immunodeficiency (HP:0004430)2.05666944
127True hermaphroditism (HP:0010459)2.04699736
128Short tibia (HP:0005736)2.03215974
129Abnormality of renin-angiotensin system (HP:0000847)2.00958195
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00839451
131Abnormality of the renal medulla (HP:0100957)2.00839308
132Urticaria (HP:0001025)2.00729807
133Peritonitis (HP:0002586)1.98682920
134Abolished electroretinogram (ERG) (HP:0000550)1.98161631
135Pancreatitis (HP:0001733)1.98152962
136Diminished movement (HP:0002374)1.98136060
137Chronic obstructive pulmonary disease (HP:0006510)1.97143612
138Obstructive lung disease (HP:0006536)1.97143612
139Aortic aneurysm (HP:0004942)1.96279716
140Bone pain (HP:0002653)1.96209638
141Tubular atrophy (HP:0000092)1.95716905
142Pustule (HP:0200039)1.95537090
143Intention tremor (HP:0002080)1.94948518
144Insulin-resistant diabetes mellitus (HP:0000831)1.94946935
145Thyroid-stimulating hormone excess (HP:0002925)1.94547653
146Hyperglycemia (HP:0003074)1.94092195
147Hydroxyprolinuria (HP:0003080)1.93691440
148Abnormality of proline metabolism (HP:0010907)1.93691440
149Congenital malformation of the right heart (HP:0011723)1.92273603
150Double outlet right ventricle (HP:0001719)1.92273603
151Conjunctival telangiectasia (HP:0000524)1.91082806
152Abnormality of calcium-phosphate metabolism (HP:0100530)1.91072151
153Purpura (HP:0000979)1.90623769
154Amyloidosis (HP:0011034)1.89283113
155Abnormal platelet function (HP:0011869)1.89044133
156Impaired platelet aggregation (HP:0003540)1.89044133
157Abnormality of serine family amino acid metabolism (HP:0010894)1.88960789
158Abnormality of glycine metabolism (HP:0010895)1.88960789
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.88421899
160Abnormal drinking behavior (HP:0030082)1.88250683
161Polydipsia (HP:0001959)1.88250683
162Metabolic alkalosis (HP:0200114)1.87816671
163Cerebral aneurysm (HP:0004944)1.87791000
164Hypokalemia (HP:0002900)1.86036551
165Hypergammaglobulinemia (HP:0010702)1.86032080
166Sensorimotor neuropathy (HP:0007141)1.85907615
167Inflammation of the large intestine (HP:0002037)1.85866144
168Joint hemorrhage (HP:0005261)1.85140189
169Premature rupture of membranes (HP:0001788)1.84693674
170Increased IgE level (HP:0003212)1.84270681
171Abnormality of alanine metabolism (HP:0010916)1.84186302
172Hyperalaninemia (HP:0003348)1.84186302
173Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84186302
174Specific learning disability (HP:0001328)1.83674605
175Keratoconjunctivitis sicca (HP:0001097)1.83187876
176Proximal tubulopathy (HP:0000114)1.81744319
177Beaking of vertebral bodies (HP:0004568)1.80530412
178Keratoconjunctivitis (HP:0001096)1.80324773
179Frequent falls (HP:0002359)1.75526837
180Thoracic kyphosis (HP:0002942)1.73154154
181Stomatitis (HP:0010280)1.72957583
182Premature loss of primary teeth (HP:0006323)1.69104629
183Atrophic scars (HP:0001075)1.68332609
184Aortic dissection (HP:0002647)1.67277295
185Facial diplegia (HP:0001349)1.65982777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.21581617
2MAP4K23.06069714
3MAP3K142.95391038
4BCKDK2.87031840
5TBK12.75073489
6KIT2.74993864
7WNK32.59477358
8BLK2.53534643
9ACVR1B2.43273526
10TGFBR22.38306971
11RIPK42.37734866
12NEK92.37019279
13JAK12.25704419
14EPHB12.19573086
15JAK32.12766748
16MAP3K42.12251978
17ADRBK22.07077400
18ARAF2.00482168
19PINK11.98585840
20ERN11.97265837
21EPHA31.86060592
22FGFR41.85370975
23ERBB31.83769583
24IRAK41.80679127
25IKBKE1.78722484
26PAK31.75850829
27CASK1.69358885
28TTN1.66850897
29IKBKB1.65763034
30MATK1.63140384
31SCYL21.62573337
32MAP3K91.61707230
33ZAP701.61316199
34GRK11.61196973
35PIM21.60900401
36EPHA41.58892089
37TRPM71.55259320
38GRK61.53275647
39TAOK31.52971859
40FGFR31.49412091
41LIMK11.48981700
42TRIM281.48565499
43MAP4K11.48320326
44MAP3K131.44691276
45TRIB31.43723843
46PTK61.36578300
47LRRK21.34651259
48IRAK31.34194782
49CSF1R1.33095911
50MAPKAPK31.28696381
51CAMK1D1.27896849
52MARK11.26334441
53TESK21.25798357
54PRKCE1.25460223
55RIPK11.23883172
56NUAK11.22741138
57JAK21.21048512
58MAPK131.19167906
59HCK1.16637622
60BCR1.14640746
61CDC42BPA1.13702332
62TEC1.12698187
63LMTK21.11874106
64BTK1.10575232
65MAP2K31.09321202
66FRK1.09204333
67FLT31.08736310
68PHKG21.08552444
69PHKG11.08552444
70CSNK1G11.07497612
71SYK1.07124167
72CSNK1G31.06162894
73CSK1.05300281
74CSNK1G21.02457509
75NTRK11.02355765
76EIF2AK31.00618385
77OXSR10.98465312
78CHUK0.98054684
79DAPK20.97288608
80ITK0.94770716
81ADRBK10.94678446
82TNIK0.94395885
83LCK0.93630734
84KSR20.93277063
85PKN20.93113948
86MAP2K70.92882489
87MST1R0.92805102
88PIK3CA0.91727460
89MAPK150.90920837
90TLK10.89294846
91MAP2K60.89010983
92CDK60.85283966
93FER0.83793494
94MAP3K20.82953019
95STK390.81195575
96BMPR1B0.78531538
97NLK0.76064793
98LYN0.76038093
99PIK3CG0.75750647
100NEK60.75681805
101CAMKK20.74464837
102BMX0.74414504
103RET0.73845332
104STK100.72857219
105TGFBR10.72256216
106PLK20.70036823
107PRKG20.69641877
108MAP3K30.69550168
109MOS0.69500493
110PIM10.69398071
111NME20.69168822
112WNK40.68994334
113BMPR20.68746181
114MUSK0.67649580
115PRKCQ0.66142313
116EGFR0.66025767
117MAP2K10.65879072
118TXK0.65574431
119NTRK30.65454944
120MAP3K10.65331192
121MAPKAPK20.64788010
122IGF1R0.63370414
123PDK20.62088534
124SIK10.61462348
125CAMK1G0.60964711
126PBK0.60318390
127ABL10.60198984
128PRKAA10.60024981
129PDGFRA0.58166338
130CSNK1A1L0.58024201
131INSRR0.56944156
132PRKCI0.56801337
133MST40.55290042
134GRK70.54579169
135MARK30.54324068
136YES10.53471506
137PDGFRB0.52851457
138MAP2K20.52240420
139DYRK20.51108068
140PRKCD0.50381469
141PRKD20.50285439
142FGFR20.48876019
143CSNK1A10.48849096
144PAK40.48231061
145TIE10.47158104
146FES0.46503987
147CAMK2A0.46143895
148PRKCA0.45126435
149PRKCG0.44921825
150PTK20.44704587
151STK240.44591440
152PRKACB0.42463623
153INSR0.42310010
154KDR0.42232401
155STK30.42215645
156PRKACA0.41126192
157GSK3A0.40861200
158ABL20.40093336
159PRKACG0.38668775
160SRC0.38556282
161TESK10.37185060
162RPS6KA20.36996892
163MAPKAPK50.36581277
164SGK2230.36171891
165SGK4940.36171891
166CAMK2D0.36042937
167EIF2AK20.33844595
168CSNK1D0.33147909
169ZAK0.32571270

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.01147141
2Sulfur metabolism_Homo sapiens_hsa009202.84945946
3Leishmaniasis_Homo sapiens_hsa051402.69796584
4Lysosome_Homo sapiens_hsa041422.63252011
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.61280896
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45508956
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.37138078
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.33575535
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32943448
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31813893
11Osteoclast differentiation_Homo sapiens_hsa043802.28444643
12Pertussis_Homo sapiens_hsa051332.27935497
13Collecting duct acid secretion_Homo sapiens_hsa049662.23954837
14Malaria_Homo sapiens_hsa051441.93105879
15Tuberculosis_Homo sapiens_hsa051521.87762085
16Other glycan degradation_Homo sapiens_hsa005111.79011805
17Phagosome_Homo sapiens_hsa041451.78057427
18Toxoplasmosis_Homo sapiens_hsa051451.77881959
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.76836469
20Butanoate metabolism_Homo sapiens_hsa006501.74768646
21Caffeine metabolism_Homo sapiens_hsa002321.72520664
22Rheumatoid arthritis_Homo sapiens_hsa053231.71916165
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71843579
24Phototransduction_Homo sapiens_hsa047441.70942321
25Phenylalanine metabolism_Homo sapiens_hsa003601.62288731
26Allograft rejection_Homo sapiens_hsa053301.61636224
27Peroxisome_Homo sapiens_hsa041461.61363596
28Legionellosis_Homo sapiens_hsa051341.59995581
29Antigen processing and presentation_Homo sapiens_hsa046121.59177503
30Linoleic acid metabolism_Homo sapiens_hsa005911.58652900
31Graft-versus-host disease_Homo sapiens_hsa053321.56516786
32Measles_Homo sapiens_hsa051621.55282516
33Arachidonic acid metabolism_Homo sapiens_hsa005901.54661129
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.54520770
35Complement and coagulation cascades_Homo sapiens_hsa046101.54036762
36Renin-angiotensin system_Homo sapiens_hsa046141.53989154
37Salmonella infection_Homo sapiens_hsa051321.53346252
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52767021
39Regulation of autophagy_Homo sapiens_hsa041401.50456121
40Circadian rhythm_Homo sapiens_hsa047101.48447766
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46777939
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46173251
43Fatty acid elongation_Homo sapiens_hsa000621.45008943
44Asthma_Homo sapiens_hsa053101.43996672
45Influenza A_Homo sapiens_hsa051641.43716581
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39792337
47B cell receptor signaling pathway_Homo sapiens_hsa046621.37721690
48Apoptosis_Homo sapiens_hsa042101.36197498
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35787264
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35107129
51Fat digestion and absorption_Homo sapiens_hsa049751.34010036
52TNF signaling pathway_Homo sapiens_hsa046681.33688400
53Ether lipid metabolism_Homo sapiens_hsa005651.33078974
54Protein export_Homo sapiens_hsa030601.33022407
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.32292688
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30570894
57Amoebiasis_Homo sapiens_hsa051461.29205481
58Chemical carcinogenesis_Homo sapiens_hsa052041.27664274
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26755425
60Selenocompound metabolism_Homo sapiens_hsa004501.23827416
61Shigellosis_Homo sapiens_hsa051311.22796412
62Propanoate metabolism_Homo sapiens_hsa006401.22374389
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20222098
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19172810
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18561984
66Nitrogen metabolism_Homo sapiens_hsa009101.16186871
67Nicotine addiction_Homo sapiens_hsa050331.15563101
68Retinol metabolism_Homo sapiens_hsa008301.15238241
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14914004
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12653562
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11582451
72Insulin secretion_Homo sapiens_hsa049111.11299203
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.07064007
74Histidine metabolism_Homo sapiens_hsa003401.06548850
75Serotonergic synapse_Homo sapiens_hsa047261.05392508
76Synaptic vesicle cycle_Homo sapiens_hsa047211.04208414
77Hematopoietic cell lineage_Homo sapiens_hsa046401.03349970
78Hepatitis C_Homo sapiens_hsa051601.01380029
79Viral myocarditis_Homo sapiens_hsa054161.01268862
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00568539
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00334791
82Oxidative phosphorylation_Homo sapiens_hsa001901.00138159
83Chemokine signaling pathway_Homo sapiens_hsa040620.98823103
84GABAergic synapse_Homo sapiens_hsa047270.98495592
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97980469
86African trypanosomiasis_Homo sapiens_hsa051430.97690905
87Tyrosine metabolism_Homo sapiens_hsa003500.95776530
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93086186
89Glutathione metabolism_Homo sapiens_hsa004800.90872842
90Hepatitis B_Homo sapiens_hsa051610.90494822
91beta-Alanine metabolism_Homo sapiens_hsa004100.90317765
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89448270
93Platelet activation_Homo sapiens_hsa046110.87278617
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86454287
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85925323
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85319981
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84726178
98Vibrio cholerae infection_Homo sapiens_hsa051100.84538800
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83899337
100Autoimmune thyroid disease_Homo sapiens_hsa053200.83702566
101Circadian entrainment_Homo sapiens_hsa047130.82511088
102Taste transduction_Homo sapiens_hsa047420.81145275
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80519500
104Chronic myeloid leukemia_Homo sapiens_hsa052200.79627003
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.78537477
106Pancreatic cancer_Homo sapiens_hsa052120.76967931
107Renin secretion_Homo sapiens_hsa049240.76199671
108Morphine addiction_Homo sapiens_hsa050320.74218127
109Vitamin digestion and absorption_Homo sapiens_hsa049770.73793173
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73238324
111ECM-receptor interaction_Homo sapiens_hsa045120.72350344
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71935381
113Acute myeloid leukemia_Homo sapiens_hsa052210.70681016
114Prion diseases_Homo sapiens_hsa050200.70125130
115Proteoglycans in cancer_Homo sapiens_hsa052050.70023035
116Prolactin signaling pathway_Homo sapiens_hsa049170.67318042
117Focal adhesion_Homo sapiens_hsa045100.67127190
118PPAR signaling pathway_Homo sapiens_hsa033200.66896202
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.66011828
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.65838287
121Herpes simplex infection_Homo sapiens_hsa051680.64717596
122Sphingolipid metabolism_Homo sapiens_hsa006000.64492027
123Endocytosis_Homo sapiens_hsa041440.63777015
124Arginine biosynthesis_Homo sapiens_hsa002200.63636878
125Type I diabetes mellitus_Homo sapiens_hsa049400.63530545
126Dopaminergic synapse_Homo sapiens_hsa047280.63123543
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.63001194
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.61891912
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61738159
130Insulin resistance_Homo sapiens_hsa049310.58384461
131Fatty acid metabolism_Homo sapiens_hsa012120.58221451
132Folate biosynthesis_Homo sapiens_hsa007900.57443372
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56285309
134Amphetamine addiction_Homo sapiens_hsa050310.55297869
135Adherens junction_Homo sapiens_hsa045200.54652096
136Pancreatic secretion_Homo sapiens_hsa049720.54083407
137Small cell lung cancer_Homo sapiens_hsa052220.53053498
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52037321
139Cocaine addiction_Homo sapiens_hsa050300.51873792
140ABC transporters_Homo sapiens_hsa020100.51038917
141Glycerolipid metabolism_Homo sapiens_hsa005610.50992615
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49312144
143Protein digestion and absorption_Homo sapiens_hsa049740.48761864
144Metabolic pathways_Homo sapiens_hsa011000.47492458
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47201228
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47106731
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46006617
148T cell receptor signaling pathway_Homo sapiens_hsa046600.45059396
149Long-term depression_Homo sapiens_hsa047300.43090269
150Fatty acid degradation_Homo sapiens_hsa000710.42237133
151HIF-1 signaling pathway_Homo sapiens_hsa040660.41990481
152VEGF signaling pathway_Homo sapiens_hsa043700.41863760
153Salivary secretion_Homo sapiens_hsa049700.40696210
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.40543815
155Ovarian steroidogenesis_Homo sapiens_hsa049130.38652303
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.37469065
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36888826
158Glutamatergic synapse_Homo sapiens_hsa047240.36395778
159Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35872301
160Arginine and proline metabolism_Homo sapiens_hsa003300.35092829
161Starch and sucrose metabolism_Homo sapiens_hsa005000.34206915
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34113235
163Melanoma_Homo sapiens_hsa052180.33904059
164Mineral absorption_Homo sapiens_hsa049780.33544469
165Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33341795
166Olfactory transduction_Homo sapiens_hsa047400.33043112
167Primary immunodeficiency_Homo sapiens_hsa053400.32217032
168Tryptophan metabolism_Homo sapiens_hsa003800.32136019
169Steroid biosynthesis_Homo sapiens_hsa001000.31516108
170Dorso-ventral axis formation_Homo sapiens_hsa043200.31011156
171Thyroid cancer_Homo sapiens_hsa052160.30237774
172Primary bile acid biosynthesis_Homo sapiens_hsa001200.29890337
173Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29589046
174Basal transcription factors_Homo sapiens_hsa030220.29108752

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