VSTM2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.60282697
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.02638689
3neuron cell-cell adhesion (GO:0007158)5.90644428
4synaptic vesicle exocytosis (GO:0016079)5.82942187
5regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.56073221
6regulation of glutamate receptor signaling pathway (GO:1900449)5.39183604
7locomotory exploration behavior (GO:0035641)5.37404703
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30918406
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.22163980
10protein localization to synapse (GO:0035418)5.00370857
11neurotransmitter secretion (GO:0007269)4.88898675
12pyrimidine nucleobase catabolic process (GO:0006208)4.87297962
13glutamate secretion (GO:0014047)4.82152548
14startle response (GO:0001964)4.79268601
15neurotransmitter-gated ion channel clustering (GO:0072578)4.75837323
16neuronal action potential propagation (GO:0019227)4.67945193
17regulation of synaptic vesicle exocytosis (GO:2000300)4.67680909
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.64016723
19exploration behavior (GO:0035640)4.63954274
20gamma-aminobutyric acid transport (GO:0015812)4.60883778
21synaptic vesicle maturation (GO:0016188)4.56864750
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.49284808
23neuron-neuron synaptic transmission (GO:0007270)4.44027469
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25541788
25positive regulation of synapse maturation (GO:0090129)4.24760213
26establishment of mitochondrion localization (GO:0051654)4.22352544
27synaptic vesicle docking involved in exocytosis (GO:0016081)4.21083660
28presynaptic membrane assembly (GO:0097105)4.20677351
29synaptic transmission, glutamatergic (GO:0035249)4.18327950
30nucleobase catabolic process (GO:0046113)4.15385074
31regulation of synaptic vesicle transport (GO:1902803)4.11571025
32glutamate receptor signaling pathway (GO:0007215)4.09894431
33gamma-aminobutyric acid signaling pathway (GO:0007214)4.04465795
34long-term synaptic potentiation (GO:0060291)4.00145336
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.99216031
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97339683
37neurotransmitter transport (GO:0006836)3.91599204
38postsynaptic membrane organization (GO:0001941)3.90438170
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.86307059
40regulation of neuronal synaptic plasticity (GO:0048168)3.85549071
41neuron recognition (GO:0008038)3.84583927
42long-term memory (GO:0007616)3.81992839
43presynaptic membrane organization (GO:0097090)3.78552764
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.77646746
45glycosphingolipid biosynthetic process (GO:0006688)3.75766489
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75068538
47response to histamine (GO:0034776)3.73224580
48proline transport (GO:0015824)3.69806570
49cell migration in hindbrain (GO:0021535)3.67963832
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66229715
51regulation of neurotransmitter levels (GO:0001505)3.61848552
52positive regulation of membrane potential (GO:0045838)3.61156491
53amino acid import (GO:0043090)3.60886435
54C4-dicarboxylate transport (GO:0015740)3.59404623
55positive regulation of synapse assembly (GO:0051965)3.59295638
56energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.57476838
57ATP hydrolysis coupled proton transport (GO:0015991)3.57476838
58regulation of synapse maturation (GO:0090128)3.56738110
59positive regulation of potassium ion transmembrane transport (GO:1901381)3.54807014
60regulation of synapse structural plasticity (GO:0051823)3.50471508
61regulation of postsynaptic membrane potential (GO:0060078)3.49064795
62transferrin transport (GO:0033572)3.48836707
63regulation of synaptic transmission, GABAergic (GO:0032228)3.45637682
64transmission of nerve impulse (GO:0019226)3.38893827
65synapse assembly (GO:0007416)3.38183837
66regulation of synaptic plasticity (GO:0048167)3.37912051
67striatum development (GO:0021756)3.36159030
68layer formation in cerebral cortex (GO:0021819)3.35880913
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31822123
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31211891
71succinate metabolic process (GO:0006105)3.30102861
72regulation of female receptivity (GO:0045924)3.29548709
73cellular potassium ion homeostasis (GO:0030007)3.28879099
74behavioral defense response (GO:0002209)3.26881627
75behavioral fear response (GO:0001662)3.26881627
76trivalent inorganic cation transport (GO:0072512)3.25024341
77ferric iron transport (GO:0015682)3.25024341
78female mating behavior (GO:0060180)3.24839987
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21887605
80acidic amino acid transport (GO:0015800)3.21488844
81positive regulation of vesicle fusion (GO:0031340)3.21484896
82sodium ion export (GO:0071436)3.19216273
83positive regulation of synaptic transmission (GO:0050806)3.18349925
84regulation of voltage-gated calcium channel activity (GO:1901385)3.16000212
85membrane depolarization during action potential (GO:0086010)3.15930059
86synaptic transmission (GO:0007268)3.15207504
87response to dietary excess (GO:0002021)3.14821557
88learning (GO:0007612)3.14805460
89activation of protein kinase A activity (GO:0034199)3.13991990
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13794551
91intraspecies interaction between organisms (GO:0051703)3.13168117
92social behavior (GO:0035176)3.13168117
93adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.12570712
94protein insertion into membrane (GO:0051205)3.12200682
95regulation of neurotransmitter secretion (GO:0046928)3.11502207
96synaptic vesicle endocytosis (GO:0048488)3.10755572
97detection of calcium ion (GO:0005513)3.10257461
98membrane hyperpolarization (GO:0060081)3.10025491
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09179113
100cerebellar granule cell differentiation (GO:0021707)3.08548234
101response to cocaine (GO:0042220)3.05981509
102neuromuscular process controlling posture (GO:0050884)3.05646475
103regulation of penile erection (GO:0060405)3.05553790
104behavioral response to cocaine (GO:0048148)3.05361220
105axonal fasciculation (GO:0007413)3.05165485
106mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.05100837
107regulation of feeding behavior (GO:0060259)3.05084246
108cerebellar Purkinje cell differentiation (GO:0021702)3.04421491
109fear response (GO:0042596)3.03774814
110membrane depolarization (GO:0051899)3.03399437
111regulation of synaptic transmission (GO:0050804)3.03093458
112neuromuscular synaptic transmission (GO:0007274)3.02633232
113regulation of synapse assembly (GO:0051963)3.01951557
114neurofilament cytoskeleton organization (GO:0060052)3.01121281
115negative regulation of dendrite morphogenesis (GO:0050774)3.00600902
116regulation of glutamate secretion (GO:0014048)3.00590651
117dendritic spine morphogenesis (GO:0060997)3.00542558
118cellular response to ammonium ion (GO:0071242)3.00348937
119serotonin metabolic process (GO:0042428)2.99018977
120dendrite morphogenesis (GO:0048813)2.98545035
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97547086
122neuronal ion channel clustering (GO:0045161)2.97197860
123regulation of vesicle fusion (GO:0031338)2.96583985
124synapse organization (GO:0050808)2.94902108
125regulation of neurotransmitter transport (GO:0051588)2.94256290
126L-amino acid import (GO:0043092)2.93645210
127establishment of synaptic vesicle localization (GO:0097480)2.93535253
128synaptic vesicle transport (GO:0048489)2.93535253
129regulation of dendritic spine morphogenesis (GO:0061001)2.92514636
130auditory behavior (GO:0031223)2.91170616
131retinal cone cell development (GO:0046549)2.89646177
132hippocampus development (GO:0021766)2.88397905
133signal release (GO:0023061)2.87136165
134primary amino compound metabolic process (GO:1901160)2.86571400
135regulation of protein kinase A signaling (GO:0010738)2.86088069
136glycine transport (GO:0015816)2.83656512
137establishment of vesicle localization (GO:0051650)2.81875158
138regulation of dendritic spine development (GO:0060998)2.74208427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.03496669
2GBX2_23144817_ChIP-Seq_PC3_Human4.35504597
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19664303
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07535495
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04857362
6TAF15_26573619_Chip-Seq_HEK293_Human2.92675132
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67614051
8REST_21632747_ChIP-Seq_MESCs_Mouse2.63416798
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.51888566
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51449339
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49946006
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49946006
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49593930
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48818848
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48582629
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39583343
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35536492
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34173397
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.32732238
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31497721
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24499333
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.22217384
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.18976595
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16446762
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.08028059
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07468324
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04827357
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01892697
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.00486859
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.99578643
31AR_21572438_ChIP-Seq_LNCaP_Human1.98431974
32SMAD4_21799915_ChIP-Seq_A2780_Human1.91516054
33DROSHA_22980978_ChIP-Seq_HELA_Human1.88357575
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87098690
35* P300_19829295_ChIP-Seq_ESCs_Human1.79476298
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78750503
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71287309
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.69238781
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68060977
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63696674
41* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62986795
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.58998986
43* FUS_26573619_Chip-Seq_HEK293_Human1.57550309
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53122739
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52711739
46IGF1R_20145208_ChIP-Seq_DFB_Human1.52297939
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.51091549
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48315442
49AR_25329375_ChIP-Seq_VCAP_Human1.47812253
50RNF2_27304074_Chip-Seq_NSC_Mouse1.47410717
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.46173804
52ZNF274_21170338_ChIP-Seq_K562_Hela1.45158081
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44302832
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44163647
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42684004
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41005474
57ER_23166858_ChIP-Seq_MCF-7_Human1.40077046
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35397574
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.35175992
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34683645
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.30527775
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28193461
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24941007
64VDR_22108803_ChIP-Seq_LS180_Human1.24919446
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23721909
66* STAT3_23295773_ChIP-Seq_U87_Human1.22796837
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21921636
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20974405
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20546215
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18581216
71TCF4_23295773_ChIP-Seq_U87_Human1.17636675
72JUN_21703547_ChIP-Seq_K562_Human1.15722142
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15527057
74* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13288513
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.12948901
76RUNX2_22187159_ChIP-Seq_PCA_Human1.12787076
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12052998
78AR_19668381_ChIP-Seq_PC3_Human1.10277975
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07082368
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06955785
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06923509
82* AHR_22903824_ChIP-Seq_MCF-7_Human1.04255655
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.04144023
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.02552687
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.02507459
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01671019
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01444768
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00785103
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99974033
90TP53_18474530_ChIP-ChIP_U2OS_Human0.98658376
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98041666
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.97906118
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97711814
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97410477
95EWS_26573619_Chip-Seq_HEK293_Human0.97309972
96BCAT_22108803_ChIP-Seq_LS180_Human0.97068379
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96795457
98KDM2B_26808549_Chip-Seq_REH_Human0.95703053
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95593210
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95140296
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94041060
102CBP_20019798_ChIP-Seq_JUKART_Human0.94041060
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93954006
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93348592
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93348592
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93218458
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93105651
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91367596
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90318148
110FLI1_27457419_Chip-Seq_LIVER_Mouse0.89957066
111TAL1_26923725_Chip-Seq_HPCs_Mouse0.89651489
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89639605
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89501135
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.88403325
115P53_22387025_ChIP-Seq_ESCs_Mouse0.88128361
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87526638
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87260847
118ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85444891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.39867248
2MP0003880_abnormal_central_pattern5.06065485
3MP0003635_abnormal_synaptic_transmissio4.07470397
4MP0002822_catalepsy4.01495693
5MP0009745_abnormal_behavioral_response3.67150149
6MP0009046_muscle_twitch3.61845837
7MP0002064_seizures3.51360936
8MP0002063_abnormal_learning/memory/cond3.31588799
9MP0002572_abnormal_emotion/affect_behav3.00536723
10MP0004270_analgesia2.89381562
11MP0001968_abnormal_touch/_nociception2.86947248
12MP0002272_abnormal_nervous_system2.73187412
13MP0001486_abnormal_startle_reflex2.59949393
14MP0002735_abnormal_chemical_nociception2.58032489
15MP0001501_abnormal_sleep_pattern2.55667617
16MP0005423_abnormal_somatic_nervous2.54033969
17MP0002734_abnormal_mechanical_nocicepti2.45797334
18MP0002736_abnormal_nociception_after2.36130847
19MP0005646_abnormal_pituitary_gland2.17476497
20MP0006276_abnormal_autonomic_nervous2.16177182
21MP0001440_abnormal_grooming_behavior2.15128021
22MP0009780_abnormal_chondrocyte_physiolo2.10362463
23MP0002067_abnormal_sensory_capabilities2.09269548
24MP0003787_abnormal_imprinting1.94137492
25MP0002733_abnormal_thermal_nociception1.92744018
26MP0001970_abnormal_pain_threshold1.90469395
27MP0003122_maternal_imprinting1.87491786
28MP0001529_abnormal_vocalization1.82056212
29MP0002557_abnormal_social/conspecific_i1.80021960
30MP0002184_abnormal_innervation1.79182505
31MP0004924_abnormal_behavior1.78911256
32MP0005386_behavior/neurological_phenoty1.78911256
33MP0004142_abnormal_muscle_tone1.78284890
34MP0003329_amyloid_beta_deposits1.76434821
35MP0002837_dystrophic_cardiac_calcinosis1.76194618
36MP0003879_abnormal_hair_cell1.72109084
37MP0008569_lethality_at_weaning1.65352199
38MP0001984_abnormal_olfaction1.62247105
39MP0000778_abnormal_nervous_system1.56395153
40MP0004811_abnormal_neuron_physiology1.49845825
41MP0002066_abnormal_motor_capabilities/c1.41776720
42MP0001905_abnormal_dopamine_level1.41103680
43MP0002876_abnormal_thyroid_physiology1.41042353
44MP0005645_abnormal_hypothalamus_physiol1.39129703
45MP0000955_abnormal_spinal_cord1.35069347
46MP0001188_hyperpigmentation1.34299384
47MP0002909_abnormal_adrenal_gland1.32661117
48MP0002882_abnormal_neuron_morphology1.32642778
49MP0002102_abnormal_ear_morphology1.24455862
50MP0000013_abnormal_adipose_tissue1.17611644
51MP0000751_myopathy1.12857632
52MP0004858_abnormal_nervous_system1.08986135
53MP0004885_abnormal_endolymph1.08603764
54MP0003938_abnormal_ear_development1.05892204
55MP0001502_abnormal_circadian_rhythm1.05123326
56MP0005551_abnormal_eye_electrophysiolog1.04402423
57MP0002152_abnormal_brain_morphology1.01066212
58MP0010386_abnormal_urinary_bladder1.01009334
59MP0003633_abnormal_nervous_system0.97232313
60MP0008872_abnormal_physiological_respon0.96147299
61MP0003631_nervous_system_phenotype0.95527621
62MP0002069_abnormal_eating/drinking_beha0.95155920
63MP0001963_abnormal_hearing_physiology0.94932491
64MP0004085_abnormal_heartbeat0.93790267
65MP0004215_abnormal_myocardial_fiber0.90902450
66MP0001177_atelectasis0.90382372
67MP0002229_neurodegeneration0.88539859
68MP0000049_abnormal_middle_ear0.87301887
69MP0004147_increased_porphyrin_level0.86534377
70MP0005187_abnormal_penis_morphology0.86386096
71MP0008789_abnormal_olfactory_epithelium0.86095681
72MP0004742_abnormal_vestibular_system0.84364362
73MP0003632_abnormal_nervous_system0.83238696
74MP0000604_amyloidosis0.83216236
75MP0004484_altered_response_of0.82494747
76MP0008877_abnormal_DNA_methylation0.79732204
77MP0005535_abnormal_body_temperature0.78820298
78MP0008874_decreased_physiological_sensi0.78631772
79MP0002234_abnormal_pharynx_morphology0.77545114
80MP0001270_distended_abdomen0.76249637
81MP0000631_abnormal_neuroendocrine_gland0.75703168
82MP0002751_abnormal_autonomic_nervous0.75256013
83MP0002752_abnormal_somatic_nervous0.74840533
84MP0003646_muscle_fatigue0.74242037
85MP0001986_abnormal_taste_sensitivity0.73628563
86MP0003121_genomic_imprinting0.72928329
87MP0003123_paternal_imprinting0.71669890
88MP0001664_abnormal_digestion0.71099781
89MP0005394_taste/olfaction_phenotype0.70833917
90MP0005499_abnormal_olfactory_system0.70833917
91MP0003634_abnormal_glial_cell0.69502411
92MP0002332_abnormal_exercise_endurance0.69206524
93MP0005084_abnormal_gallbladder_morpholo0.68621026
94MP0002090_abnormal_vision0.67617396
95MP0003221_abnormal_cardiomyocyte_apopto0.64825502
96MP0000639_abnormal_adrenal_gland0.63832705
97MP0002653_abnormal_ependyma_morphology0.63666639
98MP0003861_abnormal_nervous_system0.62237297
99MP0003137_abnormal_impulse_conducting0.61647944
100MP0001943_abnormal_respiration0.61388856
101MP0000026_abnormal_inner_ear0.59657858
102MP0003119_abnormal_digestive_system0.59219017
103MP0004133_heterotaxia0.59006014
104MP0000920_abnormal_myelination0.58759940
105MP0002638_abnormal_pupillary_reflex0.57379134
106MP0001485_abnormal_pinna_reflex0.56508725
107MP0005171_absent_coat_pigmentation0.56004474
108MP0004233_abnormal_muscle_weight0.55096672
109MP0005623_abnormal_meninges_morphology0.54709846
110MP0003690_abnormal_glial_cell0.54309706
111MP0010770_preweaning_lethality0.53568685
112MP0002082_postnatal_lethality0.53568685
113MP0006035_abnormal_mitochondrial_morpho0.52327333
114MP0005448_abnormal_energy_balance0.51307728
115MP0010769_abnormal_survival0.50691621
116MP0004043_abnormal_pH_regulation0.50401038
117MP0003956_abnormal_body_size0.48758748
118MP0010768_mortality/aging0.47341622

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.79750380
2Atonic seizures (HP:0010819)6.21653563
3Focal seizures (HP:0007359)5.69744659
4Febrile seizures (HP:0002373)5.51626227
5Epileptic encephalopathy (HP:0200134)5.38823361
6Myokymia (HP:0002411)5.25308429
7Hyperventilation (HP:0002883)5.18924076
8Absence seizures (HP:0002121)4.84577481
9Visual hallucinations (HP:0002367)4.81280444
10Dialeptic seizures (HP:0011146)4.42121188
11Generalized tonic-clonic seizures (HP:0002069)4.10808496
12Progressive cerebellar ataxia (HP:0002073)4.10352181
13Progressive inability to walk (HP:0002505)4.06484106
14Split foot (HP:0001839)3.97017452
15Broad-based gait (HP:0002136)3.58191134
16Lissencephaly (HP:0001339)3.24815398
17Polyphagia (HP:0002591)3.20925297
18Impaired social interactions (HP:0000735)3.10347649
19Abnormal social behavior (HP:0012433)3.10347649
20Abnormal eating behavior (HP:0100738)3.06225723
21Gaze-evoked nystagmus (HP:0000640)3.04566842
22Inability to walk (HP:0002540)3.02904851
23Abnormal hair whorl (HP:0010721)3.00369007
24Dysdiadochokinesis (HP:0002075)2.96414800
25Poor eye contact (HP:0000817)2.95994434
26Impaired vibration sensation in the lower limbs (HP:0002166)2.94366976
27Gait imbalance (HP:0002141)2.92444355
28Excessive salivation (HP:0003781)2.89747572
29Drooling (HP:0002307)2.89747572
30Diplopia (HP:0000651)2.81346297
31Abnormality of binocular vision (HP:0011514)2.81346297
32Acute necrotizing encephalopathy (HP:0006965)2.79875436
33Truncal ataxia (HP:0002078)2.79861696
34Lower limb muscle weakness (HP:0007340)2.74842501
35Clonus (HP:0002169)2.74661998
36Amblyopia (HP:0000646)2.73203347
37Abnormal mitochondria in muscle tissue (HP:0008316)2.72315773
38Pheochromocytoma (HP:0002666)2.71861677
39Epileptiform EEG discharges (HP:0011182)2.70209825
40Anxiety (HP:0000739)2.68975082
41Limb dystonia (HP:0002451)2.67278652
42Retinal dysplasia (HP:0007973)2.66870942
43Absent speech (HP:0001344)2.66841131
44Poor suck (HP:0002033)2.64905717
45Depression (HP:0000716)2.61063257
46Progressive macrocephaly (HP:0004481)2.59458648
47Neuroendocrine neoplasm (HP:0100634)2.59337379
48Congenital primary aphakia (HP:0007707)2.57929277
49EEG with generalized epileptiform discharges (HP:0011198)2.57396639
50Amyotrophic lateral sclerosis (HP:0007354)2.55178693
51Failure to thrive in infancy (HP:0001531)2.53677320
52Medial flaring of the eyebrow (HP:0010747)2.47122969
53Delusions (HP:0000746)2.46800239
54Hypsarrhythmia (HP:0002521)2.46417511
55Action tremor (HP:0002345)2.45876493
56Peripheral hypomyelination (HP:0007182)2.45257713
57Thyroid-stimulating hormone excess (HP:0002925)2.43363073
58Dysmetria (HP:0001310)2.42762782
59Mutism (HP:0002300)2.42708874
60Nephrogenic diabetes insipidus (HP:0009806)2.40247828
61Postural instability (HP:0002172)2.37855617
62Status epilepticus (HP:0002133)2.37713129
63Resting tremor (HP:0002322)2.37651751
64Protruding tongue (HP:0010808)2.37006486
65Scanning speech (HP:0002168)2.36579541
66Fetal akinesia sequence (HP:0001989)2.36229353
67Supranuclear gaze palsy (HP:0000605)2.35143708
68Ankle clonus (HP:0011448)2.35072283
69Ulnar claw (HP:0001178)2.34400811
70Hyperthyroidism (HP:0000836)2.34105283
71Cerebral hypomyelination (HP:0006808)2.30691019
72Bradykinesia (HP:0002067)2.28672512
73Specific learning disability (HP:0001328)2.28659791
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.28520565
75Cortical dysplasia (HP:0002539)2.25980970
76Blue irides (HP:0000635)2.25761069
77Pachygyria (HP:0001302)2.24686857
78Intention tremor (HP:0002080)2.22610430
79Generalized myoclonic seizures (HP:0002123)2.22340077
80Abnormality of the labia minora (HP:0012880)2.20209788
81Esotropia (HP:0000565)2.17662959
82Hypoplasia of the brainstem (HP:0002365)2.16855184
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16855184
84Oligomenorrhea (HP:0000876)2.14726777
85Urinary bladder sphincter dysfunction (HP:0002839)2.13518658
86Type II lissencephaly (HP:0007260)2.12705598
87Agitation (HP:0000713)2.12427616
88Hypoplasia of the corpus callosum (HP:0002079)2.11889032
89Hemiparesis (HP:0001269)2.11420030
90CNS hypomyelination (HP:0003429)2.10775864
91Acute encephalopathy (HP:0006846)2.07954077
92Cerebral inclusion bodies (HP:0100314)2.07784960
93Genetic anticipation (HP:0003743)2.06615672
94Narrow nasal bridge (HP:0000446)2.05867336
95Abnormality of the corticospinal tract (HP:0002492)2.04573024
96Mitochondrial inheritance (HP:0001427)2.02898875
97Muscular hypotonia of the trunk (HP:0008936)2.02864442
98Akinesia (HP:0002304)2.00302407
99Vaginal atresia (HP:0000148)2.00171896
100Genital tract atresia (HP:0001827)1.99690171
101Urinary urgency (HP:0000012)1.99129633
102Paraplegia (HP:0010550)1.97672722
103Neuronal loss in central nervous system (HP:0002529)1.96914790
104Spastic gait (HP:0002064)1.96376106
105Humeroradial synostosis (HP:0003041)1.95708315
106Synostosis involving the elbow (HP:0003938)1.95708315
107Gait ataxia (HP:0002066)1.95550433
108Hemiplegia (HP:0002301)1.95399160
109Intellectual disability, severe (HP:0010864)1.94660077
110Focal dystonia (HP:0004373)1.92872944
111Abnormality of salivation (HP:0100755)1.91876000
112Impaired vibratory sensation (HP:0002495)1.91334348
113Torticollis (HP:0000473)1.91322163
114Sleep apnea (HP:0010535)1.91017232
115Generalized hypotonia (HP:0001290)1.90130506
116Stereotypic behavior (HP:0000733)1.89181321
117Hypoventilation (HP:0002791)1.87889334
118Impaired smooth pursuit (HP:0007772)1.87830677
119Neoplasm of the peripheral nervous system (HP:0100007)1.87314999
120Papilledema (HP:0001085)1.87296541
121Abnormality of the lower motor neuron (HP:0002366)1.86787801
122Neurofibrillary tangles (HP:0002185)1.86384779
123Psychosis (HP:0000709)1.85879751
124Spastic paraplegia (HP:0001258)1.85175078
125Poor coordination (HP:0002370)1.84348831
126Dysmetric saccades (HP:0000641)1.81830445
127Termporal pattern (HP:0011008)1.81805451
128Insidious onset (HP:0003587)1.81805451
129Morphological abnormality of the pyramidal tract (HP:0002062)1.81764297
130Spastic tetraplegia (HP:0002510)1.78978324
131Dyskinesia (HP:0100660)1.75497376
132Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.72557080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.67129765
2CASK4.49073020
3MAP3K43.51721820
4MAP2K73.42028270
5MAP3K123.38887976
6EPHA43.19575073
7MAP3K92.86498491
8MARK12.64522079
9MINK12.29373164
10MAP2K42.21723466
11TRIM282.18973833
12MAP4K22.12778101
13NTRK22.12153467
14PLK22.03634942
15CSNK1A1L1.79344625
16CSNK1G31.77659141
17DAPK21.75818278
18PNCK1.71854791
19DAPK11.69900289
20GRK51.65211551
21TSSK61.48014655
22PRPF4B1.46419108
23CDK191.44294300
24ARAF1.39329496
25CSNK1G11.39304775
26NTRK11.38090209
27AKT31.37751815
28PRKCG1.37108028
29PAK61.35996898
30MAPK131.35844845
31ERBB41.34779597
32CDK51.34580041
33RIPK41.34127092
34FES1.34048480
35TNIK1.31518408
36DYRK21.25708694
37KSR11.21489809
38FRK1.17088045
39CAMK2A1.16973918
40ERBB31.14541385
41SIK21.06968501
42KSR21.06590709
43CCNB11.06245076
44EPHA31.06242167
45PDK31.05822546
46PDK41.05822546
47LIMK11.04640642
48NME11.04615109
49OXSR11.02188700
50CAMKK11.01777861
51CAMK2B0.95349301
52SGK20.94314943
53SGK4940.93979114
54SGK2230.93979114
55PRKCE0.93057178
56UHMK10.89672381
57RPS6KA40.89245230
58SIK30.87795827
59MUSK0.87234085
60PHKG10.83482791
61PHKG20.83482791
62STK38L0.77619111
63CAMKK20.76345921
64PRKD30.76124054
65CDK180.75149722
66BCKDK0.74579897
67WNK30.74281068
68DYRK1A0.74090093
69BMPR20.73964676
70CDK140.73622671
71CSNK1G20.73167874
72MAP3K60.71860246
73CAMK10.71059715
74PTK2B0.69912702
75CDK150.69565499
76CDK80.68769459
77STK380.68476661
78ADRBK20.68240384
79MAP3K50.66343207
80PRKCH0.65038746
81TESK10.64246577
82PDK20.64021255
83CAMK40.63395889
84LATS20.63304533
85BRAF0.63110794
86SGK10.62696181
87BCR0.60210201
88CAMK2D0.60086492
89CAMK2G0.59468167
90MAP3K20.59171481
91SGK30.58745413
92CDK11A0.58023373
93FER0.57696550
94MAP3K130.55336959
95PAK30.54881935
96MAPK120.53187747
97GRK70.52641054
98TAOK10.50804660
99STK110.50058513
100TNK20.49925239
101ROCK20.49375607
102CSNK1D0.49259458
103PKN10.49117774
104MYLK0.48530187
105TYRO30.47238391
106FGR0.45697061
107RAF10.45058055
108RPS6KA30.42991740
109PRKAA10.41451415
110SRPK10.40926587
111PRKACA0.40276953
112CSNK1A10.39643467
113PINK10.39603746
114ADRBK10.39504799
115RET0.38997998
116PRKCZ0.38907007
117MAP3K10.38283981
118PRKCB0.37575014
119MAPK100.36300977
120DAPK30.36076115
121FGFR20.35410387
122PDK10.34907332
123PRKCA0.34622232
124FYN0.34349671
125RPS6KA50.34281072
126MAP2K10.33783238
127PRKACB0.33690811
128MAP2K60.33484666
129MARK20.32201936
130TAOK30.32119331
131GRK10.30520802
132CSNK1E0.29135939
133PRKG10.26034578

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.30950988
2Synaptic vesicle cycle_Homo sapiens_hsa047214.03429879
3Collecting duct acid secretion_Homo sapiens_hsa049663.14622044
4GABAergic synapse_Homo sapiens_hsa047273.02195462
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.91267961
6Morphine addiction_Homo sapiens_hsa050322.56999769
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.54232559
8Olfactory transduction_Homo sapiens_hsa047402.41521734
9Circadian entrainment_Homo sapiens_hsa047132.38958436
10Glutamatergic synapse_Homo sapiens_hsa047242.33270132
11Long-term potentiation_Homo sapiens_hsa047202.28255613
12Amphetamine addiction_Homo sapiens_hsa050312.20762375
13Dopaminergic synapse_Homo sapiens_hsa047282.01105828
14Oxidative phosphorylation_Homo sapiens_hsa001901.96427119
15Vibrio cholerae infection_Homo sapiens_hsa051101.93677407
16Taste transduction_Homo sapiens_hsa047421.89056425
17Salivary secretion_Homo sapiens_hsa049701.85488878
18Serotonergic synapse_Homo sapiens_hsa047261.82654752
19Long-term depression_Homo sapiens_hsa047301.75034802
20Insulin secretion_Homo sapiens_hsa049111.71542452
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68294627
22Cholinergic synapse_Homo sapiens_hsa047251.65218329
23Gastric acid secretion_Homo sapiens_hsa049711.54247793
24Calcium signaling pathway_Homo sapiens_hsa040201.52040636
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48723081
26Cocaine addiction_Homo sapiens_hsa050301.48526610
27Renin secretion_Homo sapiens_hsa049241.48211548
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39790620
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38023921
30Oxytocin signaling pathway_Homo sapiens_hsa049211.37663093
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37054227
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36849660
33Cardiac muscle contraction_Homo sapiens_hsa042601.34529786
34Parkinsons disease_Homo sapiens_hsa050121.30920874
35Alzheimers disease_Homo sapiens_hsa050101.25404560
36Type I diabetes mellitus_Homo sapiens_hsa049401.23890944
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17607535
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12573462
39Gap junction_Homo sapiens_hsa045401.10259965
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09064139
41GnRH signaling pathway_Homo sapiens_hsa049121.03484287
42Butanoate metabolism_Homo sapiens_hsa006501.02157895
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00808325
44cAMP signaling pathway_Homo sapiens_hsa040240.98824209
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98350475
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97695685
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97082304
48Phototransduction_Homo sapiens_hsa047440.96989498
49Rheumatoid arthritis_Homo sapiens_hsa053230.94349245
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92604318
51Axon guidance_Homo sapiens_hsa043600.91600026
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88445334
53Estrogen signaling pathway_Homo sapiens_hsa049150.87205107
54Circadian rhythm_Homo sapiens_hsa047100.84555782
55Huntingtons disease_Homo sapiens_hsa050160.84066228
56ErbB signaling pathway_Homo sapiens_hsa040120.83035017
57Type II diabetes mellitus_Homo sapiens_hsa049300.80668886
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78265032
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76460043
60Glioma_Homo sapiens_hsa052140.75172515
61Melanogenesis_Homo sapiens_hsa049160.73254855
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.72296605
63Regulation of autophagy_Homo sapiens_hsa041400.70957064
64Dilated cardiomyopathy_Homo sapiens_hsa054140.68463427
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67612797
66Phagosome_Homo sapiens_hsa041450.65289987
67Oocyte meiosis_Homo sapiens_hsa041140.61880195
68beta-Alanine metabolism_Homo sapiens_hsa004100.60700657
69Ether lipid metabolism_Homo sapiens_hsa005650.59703629
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57249226
71Thyroid hormone synthesis_Homo sapiens_hsa049180.54663424
72MAPK signaling pathway_Homo sapiens_hsa040100.53115366
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52329346
74Pyruvate metabolism_Homo sapiens_hsa006200.50116449
75Pancreatic secretion_Homo sapiens_hsa049720.49387331
76Alcoholism_Homo sapiens_hsa050340.47551009
77Glucagon signaling pathway_Homo sapiens_hsa049220.47142327
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45566197
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44810539
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43967648
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43921784
82Protein export_Homo sapiens_hsa030600.43739434
83Ras signaling pathway_Homo sapiens_hsa040140.43600170
84AMPK signaling pathway_Homo sapiens_hsa041520.42978366
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42897552
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40673080
87Dorso-ventral axis formation_Homo sapiens_hsa043200.40133645
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.39564242
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39404257
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36593572
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36452675
92Choline metabolism in cancer_Homo sapiens_hsa052310.35034365
93Rap1 signaling pathway_Homo sapiens_hsa040150.34859603
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34690055
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33376847
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.33075875
97Ovarian steroidogenesis_Homo sapiens_hsa049130.32888401
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32735589
99Peroxisome_Homo sapiens_hsa041460.32568666
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30596610
101Fatty acid biosynthesis_Homo sapiens_hsa000610.30492891
102Inositol phosphate metabolism_Homo sapiens_hsa005620.29284730
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27529696
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27193118
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26767870
106Melanoma_Homo sapiens_hsa052180.24970803
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.23157021
108Selenocompound metabolism_Homo sapiens_hsa004500.22522603
109Arginine and proline metabolism_Homo sapiens_hsa003300.22518741
110Prion diseases_Homo sapiens_hsa050200.21963381
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21665666
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20999977
113Hippo signaling pathway_Homo sapiens_hsa043900.20688807
114Bile secretion_Homo sapiens_hsa049760.20668679
115Linoleic acid metabolism_Homo sapiens_hsa005910.20648520
116Vitamin B6 metabolism_Homo sapiens_hsa007500.19399373
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.19385151
118African trypanosomiasis_Homo sapiens_hsa051430.19289908
119Insulin signaling pathway_Homo sapiens_hsa049100.18827691
120Endocytosis_Homo sapiens_hsa041440.16670558
121Renal cell carcinoma_Homo sapiens_hsa052110.16580726

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