VSIG10L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.42534152
2keratinization (GO:0031424)9.07813907
3regulation of water loss via skin (GO:0033561)8.79169604
4desmosome organization (GO:0002934)8.57577976
5hair cycle (GO:0042633)5.81026561
6molting cycle (GO:0042303)5.81026561
7multicellular organismal water homeostasis (GO:0050891)5.75975508
8sphingosine metabolic process (GO:0006670)5.31259114
9keratinocyte differentiation (GO:0030216)5.27776272
10sphingoid metabolic process (GO:0046519)5.07657552
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.98164178
12peptide cross-linking (GO:0018149)4.92540598
13positive regulation of interleukin-8 secretion (GO:2000484)4.88041936
14lipoxygenase pathway (GO:0019372)4.86472390
15water homeostasis (GO:0030104)4.70456933
16skin morphogenesis (GO:0043589)4.64064459
17regulation of cholesterol biosynthetic process (GO:0045540)4.56993010
18diol metabolic process (GO:0034311)4.50509004
19ectoderm development (GO:0007398)4.26048808
20epithelial cell-cell adhesion (GO:0090136)4.11712906
21gap junction assembly (GO:0016264)4.10914705
22regulation of interleukin-8 secretion (GO:2000482)4.05797590
23epidermal cell differentiation (GO:0009913)3.96576424
24long-chain fatty acid biosynthetic process (GO:0042759)3.95972404
25glucose 6-phosphate metabolic process (GO:0051156)3.93667352
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.90538707
27detection of bacterium (GO:0016045)3.82858359
28regulation of cell proliferation involved in kidney development (GO:1901722)3.80132851
29glucosamine-containing compound catabolic process (GO:1901072)3.73192572
30negative regulation of phagocytosis (GO:0050765)3.71833512
31keratinocyte proliferation (GO:0043616)3.71059316
32long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.69419696
33detection of other organism (GO:0098543)3.66675199
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58342689
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58342689
36dendritic cell migration (GO:0036336)3.55203650
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.50917420
38intermediate filament organization (GO:0045109)3.42868702
39hemidesmosome assembly (GO:0031581)3.39638252
40eyelid development in camera-type eye (GO:0061029)3.37836506
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.35304644
42thrombin receptor signaling pathway (GO:0070493)3.35122249
43megakaryocyte development (GO:0035855)3.34416521
44antigen processing and presentation of endogenous antigen (GO:0019883)3.33923529
45definitive hemopoiesis (GO:0060216)3.28108653
46linoleic acid metabolic process (GO:0043651)3.26157830
47proline biosynthetic process (GO:0006561)3.22207299
48interferon-gamma secretion (GO:0072643)3.18045824
49heterochromatin organization (GO:0070828)3.16820603
50cell-cell junction maintenance (GO:0045217)3.15786437
51amino sugar catabolic process (GO:0046348)3.15159774
52pentose metabolic process (GO:0019321)3.12591385
53L-serine transport (GO:0015825)3.10401258
54regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.10159741
55DNA replication checkpoint (GO:0000076)3.10031020
56activation of Rac GTPase activity (GO:0032863)3.09398562
57gland morphogenesis (GO:0022612)3.08899422
58regulation of natural killer cell differentiation (GO:0032823)3.04711310
59fatty-acyl-CoA biosynthetic process (GO:0046949)3.04550490
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04507692
61epidermis development (GO:0008544)3.02678987
62phospholipid scrambling (GO:0017121)3.01841911
63platelet dense granule organization (GO:0060155)3.00276983
64negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.97683194
65serine transport (GO:0032329)2.96987005
66ribosomal small subunit assembly (GO:0000028)2.96397616
67negative regulation of stress fiber assembly (GO:0051497)2.96085100
68cellular response to type I interferon (GO:0071357)2.95583957
69type I interferon signaling pathway (GO:0060337)2.95583957
70bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94538858
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94267886
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.93468121
73ceramide catabolic process (GO:0046514)2.92528401
74defense response to fungus (GO:0050832)2.89789397
75regulation of cholesterol metabolic process (GO:0090181)2.89626793
76purinergic nucleotide receptor signaling pathway (GO:0035590)2.89466314
77response to type I interferon (GO:0034340)2.89305031
78regulation of cholesterol homeostasis (GO:2000188)2.88838680
79transepithelial transport (GO:0070633)2.88598987
80atrioventricular valve morphogenesis (GO:0003181)2.88309151
81viral transcription (GO:0019083)2.88073611
82receptor catabolic process (GO:0032801)2.87666883
83epithelial cell differentiation involved in prostate gland development (GO:0060742)2.87158142
84positive regulation of glomerulus development (GO:0090193)2.85319359
85positive regulation of B cell differentiation (GO:0045579)2.83833225
86response to muramyl dipeptide (GO:0032495)2.80071133
87erythrocyte maturation (GO:0043249)2.79950901
88macrophage differentiation (GO:0030225)2.79833887
89positive regulation of cholesterol efflux (GO:0010875)2.79260635
90SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78768666
91regulation of translational fidelity (GO:0006450)2.78750715
92branching involved in mammary gland duct morphogenesis (GO:0060444)2.76123971
93regulation of necrotic cell death (GO:0010939)2.75645297
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.74479660
95glucose catabolic process (GO:0006007)2.74419240
96G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.73681306
97negative regulation of telomerase activity (GO:0051974)2.71647636
98regulation of ruffle assembly (GO:1900027)2.70660194
99cyclooxygenase pathway (GO:0019371)2.70288744
100semaphorin-plexin signaling pathway (GO:0071526)2.69473612
101translational termination (GO:0006415)2.68584957
102cotranslational protein targeting to membrane (GO:0006613)2.68367768
103protein targeting to ER (GO:0045047)2.68260274
104regulation of phospholipase A2 activity (GO:0032429)2.68052709
105pre-miRNA processing (GO:0031054)2.67486516
106interferon-gamma-mediated signaling pathway (GO:0060333)2.67380824
107positive regulation of interleukin-1 beta secretion (GO:0050718)2.66723637
108surfactant homeostasis (GO:0043129)2.65467743
109negative regulation of fatty acid biosynthetic process (GO:0045717)2.65381663
110primary alcohol catabolic process (GO:0034310)2.64233313
111negative regulation of cell fate specification (GO:0009996)2.64127272
112nucleoside transmembrane transport (GO:1901642)2.62033449
113polyketide metabolic process (GO:0030638)2.61170820
114doxorubicin metabolic process (GO:0044598)2.61170820
115daunorubicin metabolic process (GO:0044597)2.61170820
116cochlea morphogenesis (GO:0090103)2.60582737
117phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60295588
1183-UTR-mediated mRNA stabilization (GO:0070935)2.58519708
119acyl-CoA biosynthetic process (GO:0071616)2.58133926
120thioester biosynthetic process (GO:0035384)2.58133926
121DNA deamination (GO:0045006)2.57405080
122establishment of tissue polarity (GO:0007164)2.57366608
123establishment of planar polarity (GO:0001736)2.57366608
124COPI coating of Golgi vesicle (GO:0048205)2.57247242
125Golgi transport vesicle coating (GO:0048200)2.57247242
126positive regulation of interleukin-1 beta production (GO:0032731)2.56184572
127fucose catabolic process (GO:0019317)2.55364024
128L-fucose metabolic process (GO:0042354)2.55364024
129L-fucose catabolic process (GO:0042355)2.55364024
130establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55158546
131keratinocyte development (GO:0003334)2.55118795
132positive regulation of epidermal cell differentiation (GO:0045606)2.54525816
133protein retention in ER lumen (GO:0006621)2.53684548
134pentose-phosphate shunt (GO:0006098)2.53346694
135virion attachment to host cell (GO:0019062)2.52996161
136adhesion of symbiont to host cell (GO:0044650)2.52996161
137positive regulation of monocyte chemotaxis (GO:0090026)2.51972716
138chemical homeostasis within a tissue (GO:0048875)2.51537558
139regulation of histone H3-K27 methylation (GO:0061085)2.51285866
140polarized epithelial cell differentiation (GO:0030859)2.50842252
141regulation of B cell receptor signaling pathway (GO:0050855)2.50139311
142protein localization to endoplasmic reticulum (GO:0070972)2.49982258
143NADPH regeneration (GO:0006740)2.49348972
144peptide catabolic process (GO:0043171)2.48626854
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47929942
146positive regulation of steroid biosynthetic process (GO:0010893)2.46567086
147lung epithelium development (GO:0060428)2.46107795
148positive regulation of Cdc42 GTPase activity (GO:0043089)2.46025069
149dendritic cell chemotaxis (GO:0002407)2.45368074
150regulation of erythrocyte differentiation (GO:0045646)2.44369442
151antigen processing and presentation via MHC class Ib (GO:0002475)2.43961336
152positive regulation of triglyceride biosynthetic process (GO:0010867)2.41422282
153mitotic chromosome condensation (GO:0007076)2.41202191
154cellular protein complex localization (GO:0034629)2.39893391
155protein complex localization (GO:0031503)2.39711678
156response to food (GO:0032094)2.37735018
157regulation of epidermal cell differentiation (GO:0045604)2.35854341
158regulation of integrin activation (GO:0033623)2.35667265
159negative regulation of DNA-templated transcription, elongation (GO:0032785)2.35566671
160positive regulation of epidermis development (GO:0045684)2.34775919
161proline metabolic process (GO:0006560)2.33174460
162positive regulation of histone deacetylation (GO:0031065)2.33137725
163flavonoid metabolic process (GO:0009812)2.32332404
164L-serine metabolic process (GO:0006563)2.31554370
165Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.30486493
166nucleoside transport (GO:0015858)2.28714631
167negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.28364518
168cell junction maintenance (GO:0034331)2.28140228
169intestinal epithelial cell development (GO:0060576)2.28038952
170negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.27030492
171ventricular cardiac muscle cell action potential (GO:0086005)2.26984651
172regulation of chromatin binding (GO:0035561)2.23526646
173ceramide biosynthetic process (GO:0046513)2.23246000
174phospholipid efflux (GO:0033700)2.22535069
175epithelium development (GO:0060429)2.21546851
176regulation of clathrin-mediated endocytosis (GO:2000369)2.19166121
177regulation of epidermis development (GO:0045682)2.17017399
178layer formation in cerebral cortex (GO:0021819)2.16862679
179morphogenesis of embryonic epithelium (GO:0016331)2.15703620
180glycosphingolipid catabolic process (GO:0046479)2.15386696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.47118306
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.43227830
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.31985618
4E2F7_22180533_ChIP-Seq_HELA_Human3.11265071
5SCL_19346495_ChIP-Seq_HPC-7_Human2.86130559
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79436234
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.74430071
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70357606
9P63_26484246_Chip-Seq_KERATINOCYTES_Human2.68467176
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42849320
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31735757
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.25963170
13GATA1_22025678_ChIP-Seq_K562_Human2.22400186
14VDR_21846776_ChIP-Seq_THP-1_Human2.20995386
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12042129
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05430055
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00332052
18TP63_17297297_ChIP-ChIP_HaCaT_Human10.5786438
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98213178
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98005504
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97951801
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96062122
23ZNF263_19887448_ChIP-Seq_K562_Human1.87194721
24SPI1_23547873_ChIP-Seq_NB4_Human1.85779864
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.83028005
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80530427
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.80394268
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77798131
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77765432
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73119307
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72226511
32MAF_26560356_Chip-Seq_TH1_Human1.71301210
33VDR_24763502_ChIP-Seq_THP-1_Human1.70288617
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68849192
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66483230
36UTX_26944678_Chip-Seq_JUKART_Human1.65213272
37MYC_22102868_ChIP-Seq_BL_Human1.64865788
38MYB_26560356_Chip-Seq_TH2_Human1.64565516
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.62831113
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61315064
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61165229
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.60834768
43TCF7_22412390_ChIP-Seq_EML_Mouse1.60277145
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57221633
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56846953
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56747372
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56747372
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56535952
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54214379
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52652050
51NCOR1_26117541_ChIP-Seq_K562_Human1.51235775
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50732397
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.50662134
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49084300
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48380017
56KDM2B_26808549_Chip-Seq_K562_Human1.45775895
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43866726
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43601636
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42734029
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42567752
61P68_20966046_ChIP-Seq_HELA_Human1.42047748
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41981987
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41289158
64SMC4_20622854_ChIP-Seq_HELA_Human1.40974522
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40515251
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.39377777
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38723399
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.37869451
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37406952
70MYB_26560356_Chip-Seq_TH1_Human1.36975131
71XRN2_22483619_ChIP-Seq_HELA_Human1.35717693
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33933708
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32482810
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32299048
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32070142
76CTCF_27219007_Chip-Seq_Bcells_Human1.31789321
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30749273
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29031145
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26398735
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25388691
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24113235
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23988168
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22549850
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21889147
85* CREB1_26743006_Chip-Seq_LNCaP_Human1.21658003
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.20682321
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20216616
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19974330
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19761852
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18035973
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17459489
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17401107
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15018143
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14883038
95* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14078184
96E2F1_20622854_ChIP-Seq_HELA_Human1.13572775
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13402213
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12793328
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12489484
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12249363
101AR_21909140_ChIP-Seq_LNCAP_Human1.11568495
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10550168
103* LXR_22292898_ChIP-Seq_THP-1_Human1.10327501
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10087230
105* ELK3_25401928_ChIP-Seq_HUVEC_Human1.09987777
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09950754
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09445557
108BCL6_27268052_Chip-Seq_Bcells_Human1.09427932
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08687621
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08617234
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08377586
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06695658
113* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06228350
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04736881
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04588559
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04505274
117ETS1_22383799_ChIP-Seq_G1ME_Mouse1.04431894
118TET1_21451524_ChIP-Seq_MESCs_Mouse1.04350660
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04259400
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03939588
121RACK7_27058665_Chip-Seq_MCF-7_Human1.02541958
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02357283
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02173740
124KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02173740
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02173740
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02158299
127TP63_22573176_ChIP-Seq_HFKS_Human1.01746002
128E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01410749
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01102143
130KDM2B_26808549_Chip-Seq_DND41_Human1.00733985
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00355928
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00325326
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99330722
134SA1_27219007_Chip-Seq_ERYTHROID_Human0.99080550
135PU_27001747_Chip-Seq_BMDM_Mouse0.99010283
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.98910347
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.98716626
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.98662519
139UBF1/2_26484160_Chip-Seq_HMECs_Human0.98439541
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97805686
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97582342
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97477644
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97259175
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97091944
145CLOCK_20551151_ChIP-Seq_293T_Human0.95977331
146FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95813556
147BCOR_27268052_Chip-Seq_Bcells_Human0.95564854
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.95379277
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.95187106
150RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95100957
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94505880
152CTCF_20526341_ChIP-Seq_ESCs_Human0.94403374
153GABP_19822575_ChIP-Seq_HepG2_Human0.94358078
154* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93978753
155SOX2_20726797_ChIP-Seq_SW620_Human0.93598730
156SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.93258739
157PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92998103
158DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92820440
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.92374541
160GATA3_27048872_Chip-Seq_THYMUS_Human0.89894873
161RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89286081
162SPI1_20517297_ChIP-Seq_HL60_Human0.89163499
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88824094
164ATF3_27146783_Chip-Seq_COLON_Human0.88568611
165* GATA3_26560356_Chip-Seq_TH2_Human0.87439913
166TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86529142
167PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85817150
168CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85518579
169Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85437238
170FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84649924
171CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84280165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.90265870
2MP0005275_abnormal_skin_tensile4.38648091
3MP0005501_abnormal_skin_physiology3.78413663
4MP0003941_abnormal_skin_development3.15612648
5MP0000566_synostosis3.11900818
6MP0004947_skin_inflammation2.96329814
7MP0001216_abnormal_epidermal_layer2.88366218
8MP0002060_abnormal_skin_morphology2.67431289
9MP0000383_abnormal_hair_follicle2.65558631
10MP0010234_abnormal_vibrissa_follicle2.51105853
11MP0000579_abnormal_nail_morphology2.48348838
12MP0005377_hearing/vestibular/ear_phenot2.46328322
13MP0003878_abnormal_ear_physiology2.46328322
14MP0004381_abnormal_hair_follicle2.37308776
15MP0000465_gastrointestinal_hemorrhage2.33084866
16MP0002254_reproductive_system_inflammat2.31903171
17MP0003436_decreased_susceptibility_to2.28578892
18MP0010771_integument_phenotype2.26236975
19MP0002877_abnormal_melanocyte_morpholog2.25958816
20MP0002396_abnormal_hematopoietic_system2.14284682
21MP0002098_abnormal_vibrissa_morphology2.11554707
22MP0010678_abnormal_skin_adnexa2.09922579
23MP0003453_abnormal_keratinocyte_physiol2.09297258
24MP0003724_increased_susceptibility_to2.06735983
25MP0001545_abnormal_hematopoietic_system1.89365581
26MP0005397_hematopoietic_system_phenotyp1.89365581
27MP0003566_abnormal_cell_adhesion1.84879692
28MP0000377_abnormal_hair_follicle1.82238869
29MP0001835_abnormal_antigen_presentation1.79361047
30MP0010030_abnormal_orbit_morphology1.73486164
31MP0003123_paternal_imprinting1.71764212
32MP0000647_abnormal_sebaceous_gland1.67525938
33MP0009931_abnormal_skin_appearance1.66772926
34MP0000427_abnormal_hair_cycle1.64846188
35MP0005451_abnormal_body_composition1.64317413
36MP0009785_altered_susceptibility_to1.62763437
37MP0003191_abnormal_cellular_cholesterol1.62140765
38MP0003763_abnormal_thymus_physiology1.56799183
39MP0005671_abnormal_response_to1.55202021
40MP0001191_abnormal_skin_condition1.54702706
41MP0004808_abnormal_hematopoietic_stem1.54114018
42MP0009278_abnormal_bone_marrow1.52489927
43MP0000685_abnormal_immune_system1.52458502
44MP0000762_abnormal_tongue_morphology1.51905525
45MP0002148_abnormal_hypersensitivity_rea1.51835555
46MP0001243_abnormal_dermal_layer1.48337404
47MP0002009_preneoplasia1.46583429
48MP0002166_altered_tumor_susceptibility1.46343978
49MP0000367_abnormal_coat/_hair1.43605323
50MP0005000_abnormal_immune_tolerance1.42783509
51MP0002419_abnormal_innate_immunity1.42127071
52MP0005025_abnormal_response_to1.41959674
53MP0010352_gastrointestinal_tract_polyps1.41837338
54MP0005464_abnormal_platelet_physiology1.36549704
55MP0001800_abnormal_humoral_immune1.36286223
56MP0004957_abnormal_blastocyst_morpholog1.30991739
57MP0002095_abnormal_skin_pigmentation1.30126932
58MP0001853_heart_inflammation1.29738483
59MP0005409_darkened_coat_color1.26684941
60MP0008007_abnormal_cellular_replicative1.25469524
61MP0000343_altered_response_to1.24686982
62MP0005257_abnormal_intraocular_pressure1.24302515
63MP0009333_abnormal_splenocyte_physiolog1.22504622
64MP0005174_abnormal_tail_pigmentation1.22306981
65MP0002405_respiratory_system_inflammati1.19672017
66MP0004885_abnormal_endolymph1.19397634
67MP0001533_abnormal_skeleton_physiology1.18791400
68MP0004043_abnormal_pH_regulation1.18447224
69MP0000490_abnormal_crypts_of1.17936517
70MP0002452_abnormal_antigen_presenting1.17337146
71MP0000678_abnormal_parathyroid_gland1.17291930
72MP0005387_immune_system_phenotype1.16977676
73MP0001790_abnormal_immune_system1.16977676
74MP0002420_abnormal_adaptive_immunity1.15879597
75MP0000858_altered_metastatic_potential1.15456867
76MP0003315_abnormal_perineum_morphology1.15346450
77MP0001819_abnormal_immune_cell1.14168985
78MP0000467_abnormal_esophagus_morphology1.13142725
79MP0005076_abnormal_cell_differentiation1.12940089
80MP0001873_stomach_inflammation1.12373244
81MP0003111_abnormal_nucleus_morphology1.12365117
82MP0002723_abnormal_immune_serum1.11791419
83MP0004185_abnormal_adipocyte_glucose1.11789470
84MP0010155_abnormal_intestine_physiology1.10402441
85MP0005075_abnormal_melanosome_morpholog1.09296802
86MP0002006_tumorigenesis1.09094142
87MP0008875_abnormal_xenobiotic_pharmacok1.04175303
88MP0001851_eye_inflammation1.03376757
89MP0005023_abnormal_wound_healing1.01240669
90MP0001986_abnormal_taste_sensitivity1.00753481
91MP0004264_abnormal_extraembryonic_tissu0.99975373
92MP0002249_abnormal_larynx_morphology0.99083870
93MP0002398_abnormal_bone_marrow0.99036491
94MP0009672_abnormal_birth_weight0.98254088
95MP0001845_abnormal_inflammatory_respons0.98019451
96MP0001346_abnormal_lacrimal_gland0.96303978
97MP0006054_spinal_hemorrhage0.95844568
98MP0004019_abnormal_vitamin_homeostasis0.95505744
99MP0002139_abnormal_hepatobiliary_system0.94466534
100MP0004782_abnormal_surfactant_physiolog0.94037589
101MP0003693_abnormal_embryo_hatching0.93647333
102MP0005058_abnormal_lysosome_morphology0.93173473
103MP0004197_abnormal_fetal_growth/weight/0.91075908
104MP0003890_abnormal_embryonic-extraembry0.89278135
105MP0003183_abnormal_peptide_metabolism0.88037007
106MP0010094_abnormal_chromosome_stability0.87673171
107MP0002111_abnormal_tail_morphology0.85699936
108MP0002722_abnormal_immune_system0.85494307
109MP0000716_abnormal_immune_system0.83670908
110MP0000689_abnormal_spleen_morphology0.81235751
111MP0000537_abnormal_urethra_morphology0.80309261
112MP0008932_abnormal_embryonic_tissue0.79316882
113MP0003448_altered_tumor_morphology0.79059745
114MP0003705_abnormal_hypodermis_morpholog0.78397382
115MP0005499_abnormal_olfactory_system0.78178080
116MP0005394_taste/olfaction_phenotype0.78178080
117MP0004883_abnormal_blood_vessel0.77940593
118MP0005666_abnormal_adipose_tissue0.76738104
119MP0001730_embryonic_growth_arrest0.76410867
120MP0005365_abnormal_bile_salt0.76389283
121MP0009840_abnormal_foam_cell0.75746063
122MP0005310_abnormal_salivary_gland0.75368330
123MP0003806_abnormal_nucleotide_metabolis0.74869983
124MP0003011_delayed_dark_adaptation0.73393964
125MP0002429_abnormal_blood_cell0.72899312
126MP0000371_diluted_coat_color0.72431537
127MP0003136_yellow_coat_color0.70966463
128MP0008995_early_reproductive_senescence0.70899220
129MP0002089_abnormal_postnatal_growth/wei0.69678258
130MP0002019_abnormal_tumor_incidence0.68682541
131MP0008057_abnormal_DNA_replication0.67223827
132MP0000703_abnormal_thymus_morphology0.66456893
133MP0009764_decreased_sensitivity_to0.66439932
134MP0003303_peritoneal_inflammation0.66420328
135MP0005380_embryogenesis_phenotype0.65858746
136MP0001672_abnormal_embryogenesis/_devel0.65858746
137MP0009379_abnormal_foot_pigmentation0.65721488
138MP0003755_abnormal_palate_morphology0.64847507
139MP0001697_abnormal_embryo_size0.63955927
140MP0005390_skeleton_phenotype0.63646479
141MP0004233_abnormal_muscle_weight0.63495262
142MP0002697_abnormal_eye_size0.63201570
143MP0003942_abnormal_urinary_system0.62416620
144MP0003075_altered_response_to0.61391617
145MP0008469_abnormal_protein_level0.60982759
146MP0003984_embryonic_growth_retardation0.60652235
147MP0002086_abnormal_extraembryonic_tissu0.60341048
148MP0003077_abnormal_cell_cycle0.60312040
149MP0008789_abnormal_olfactory_epithelium0.59456163
150MP0003795_abnormal_bone_structure0.58169201
151MP0009053_abnormal_anal_canal0.56976588
152MP0001849_ear_inflammation0.56865084
153MP0008058_abnormal_DNA_repair0.56431734
154MP0002088_abnormal_embryonic_growth/wei0.55420352
155MP0002080_prenatal_lethality0.54723078
156MP0004133_heterotaxia0.54187434
157MP0005360_urolithiasis0.53969967
158MP0002085_abnormal_embryonic_tissue0.51841774
159MP0005083_abnormal_biliary_tract0.50649784
160MP0006292_abnormal_olfactory_placode0.49613170
161MP0000350_abnormal_cell_proliferation0.48868743
162MP0001186_pigmentation_phenotype0.47784053
163MP0001340_abnormal_eyelid_morphology0.47666662
164MP0002084_abnormal_developmental_patter0.46198848

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)6.70351648
2Hypotrichosis (HP:0001006)5.99441685
3Congenital ichthyosiform erythroderma (HP:0007431)5.19826610
4Erythema (HP:0010783)5.08268662
5Woolly hair (HP:0002224)5.08001512
6Abnormality of nail color (HP:0100643)4.80490881
7Erythroderma (HP:0001019)4.67481448
8Palmoplantar hyperkeratosis (HP:0000972)4.47998874
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.41124561
10Lip pit (HP:0100267)4.39206102
11Alopecia of scalp (HP:0002293)4.26982536
12Plantar hyperkeratosis (HP:0007556)4.25750491
13Palmar hyperkeratosis (HP:0010765)4.23989435
14Pili torti (HP:0003777)4.06519503
15Conjunctival hamartoma (HP:0100780)4.05295511
16Eczematoid dermatitis (HP:0000976)4.01101351
17Recurrent abscess formation (HP:0002722)3.89665442
18Recurrent bacterial skin infections (HP:0005406)3.87338440
19Right ventricular cardiomyopathy (HP:0011663)3.72403487
20Septate vagina (HP:0001153)3.51096095
21Ectropion (HP:0000656)3.44070416
22Gangrene (HP:0100758)3.44031133
23Onycholysis (HP:0001806)3.34067475
24Petechiae (HP:0000967)3.08556681
25Parakeratosis (HP:0001036)3.03272323
26Seborrheic dermatitis (HP:0001051)3.02752619
27Abnormal blistering of the skin (HP:0008066)3.00862366
28Abnormality of the salivary glands (HP:0010286)3.00254781
29Breast hypoplasia (HP:0003187)2.95876572
30Pruritus (HP:0000989)2.92800829
31Absent eyelashes (HP:0000561)2.91612373
32Stomach cancer (HP:0012126)2.87583139
33Sparse eyelashes (HP:0000653)2.84785916
34Corneal erosion (HP:0200020)2.74133678
35Nail dystrophy (HP:0008404)2.72750077
36Hypergammaglobulinemia (HP:0010702)2.70422393
37Abnormal hair laboratory examination (HP:0003328)2.69321271
38Curly hair (HP:0002212)2.68618582
39Hyperthyroidism (HP:0000836)2.68483647
40Myositis (HP:0100614)2.67364105
41Abnormality of the axillary hair (HP:0100134)2.67176074
42Abnormality of secondary sexual hair (HP:0009888)2.67176074
43Prolonged bleeding time (HP:0003010)2.66260110
44Thick nail (HP:0001805)2.66169262
45Elevated erythrocyte sedimentation rate (HP:0003565)2.62693894
46Thrombocytosis (HP:0001894)2.57837673
47Absent hair (HP:0002298)2.55075281
48Milia (HP:0001056)2.55068392
49Sparse scalp hair (HP:0002209)2.54369071
50Chronic otitis media (HP:0000389)2.54029931
51Brittle hair (HP:0002299)2.53294470
52Oral leukoplakia (HP:0002745)2.49181518
53Distal lower limb muscle weakness (HP:0009053)2.48206649
54Congenital, generalized hypertrichosis (HP:0004540)2.45650711
55Abnormality of placental membranes (HP:0011409)2.41150860
56Amniotic constriction ring (HP:0009775)2.41150860
57Palmoplantar keratoderma (HP:0000982)2.40812536
58Interstitial pulmonary disease (HP:0006530)2.39829706
59Aplastic anemia (HP:0001915)2.38931131
60Hypohidrosis (HP:0000966)2.37031424
61Truncus arteriosus (HP:0001660)2.36204221
62Sepsis (HP:0100806)2.35791489
63Hemorrhage of the eye (HP:0011885)2.32103696
64Blepharitis (HP:0000498)2.30065388
65IgM deficiency (HP:0002850)2.28926498
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.28241808
67Skin ulcer (HP:0200042)2.28231497
68Recurrent viral infections (HP:0004429)2.25849484
69Hypoplasia of the thymus (HP:0000778)2.22322499
70Overlapping toe (HP:0001845)2.21868309
71Reticulocytosis (HP:0001923)2.21577988
72Fragile nails (HP:0001808)2.14408861
73Hypoplastic labia majora (HP:0000059)2.13911946
74Ridged nail (HP:0001807)2.13801552
75Natal tooth (HP:0000695)2.08816752
76Acanthosis nigricans (HP:0000956)2.06061751
77Lack of skin elasticity (HP:0100679)2.04914123
78Glomerulonephritis (HP:0000099)2.04606177
79Ventricular tachycardia (HP:0004756)2.03434552
80Fragile skin (HP:0001030)2.03210660
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02272844
82Selective tooth agenesis (HP:0001592)2.02216292
83Deviation of the thumb (HP:0009603)1.99915079
84Abnormal large intestine physiology (HP:0012700)1.99686723
85Pustule (HP:0200039)1.99648133
86Proximal placement of thumb (HP:0009623)1.99601578
87Aplasia involving bones of the extremities (HP:0009825)1.99588125
88Aplasia involving bones of the upper limbs (HP:0009823)1.99588125
89Aplasia of the phalanges of the hand (HP:0009802)1.99588125
90Increased cerebral lipofuscin (HP:0011813)1.98995130
91Recurrent fungal infections (HP:0002841)1.98953183
92Generalized aminoaciduria (HP:0002909)1.98914669
93Urticaria (HP:0001025)1.98782170
94Trismus (HP:0000211)1.95923804
95Furrowed tongue (HP:0000221)1.94641554
96Vertebral compression fractures (HP:0002953)1.94344084
97Nasolacrimal duct obstruction (HP:0000579)1.94023348
98Abnormality of the labia majora (HP:0012881)1.93939053
99Neoplasm of the tracheobronchial system (HP:0100552)1.92600641
100Bowel incontinence (HP:0002607)1.91406407
101Neonatal death (HP:0003811)1.90847903
102Purpura (HP:0000979)1.90187923
103Broad alveolar ridges (HP:0000187)1.89163172
104Squamous cell carcinoma (HP:0002860)1.88502894
105Abnormality of the prostate (HP:0008775)1.88272995
106Abnormality of macrophages (HP:0004311)1.86957437
107Abnormality of reticulocytes (HP:0004312)1.86686116
108Dry skin (HP:0000958)1.86655938
109Recurrent skin infections (HP:0001581)1.82411360
110Panhypogammaglobulinemia (HP:0003139)1.81247396
111Distal arthrogryposis (HP:0005684)1.78551376
112Anonychia (HP:0001798)1.77072822
113Chronic obstructive pulmonary disease (HP:0006510)1.77017289
114Obstructive lung disease (HP:0006536)1.77017289
115Advanced eruption of teeth (HP:0006288)1.76432532
116Epistaxis (HP:0000421)1.75973709
117Preauricular skin tag (HP:0000384)1.75799158
118Recurrent corneal erosions (HP:0000495)1.73804572
119Abnormality of cells of the erythroid lineage (HP:0012130)1.73029289
120Areflexia of lower limbs (HP:0002522)1.72744362
121Periodontitis (HP:0000704)1.72531325
122Abnormality of the lacrimal duct (HP:0011481)1.71050587
123Mediastinal lymphadenopathy (HP:0100721)1.71025020
124Abnormality of the dental root (HP:0006486)1.69529769
125Taurodontia (HP:0000679)1.69529769
126Abnormality of permanent molar morphology (HP:0011071)1.69529769
127Papilledema (HP:0001085)1.69265008
128Labial hypoplasia (HP:0000066)1.69147872
129Popliteal pterygium (HP:0009756)1.66977603
130Vacuolated lymphocytes (HP:0001922)1.66756245
131Gingival bleeding (HP:0000225)1.65823532
132Partial duplication of thumb phalanx (HP:0009944)1.65765283
133Hypoplastic female external genitalia (HP:0012815)1.65644622
134Nasal polyposis (HP:0100582)1.65449429
135Hypoproteinemia (HP:0003075)1.64531192
136Ulnar deviation of the wrist (HP:0003049)1.64288701
137Eosinophilia (HP:0001880)1.63810250
138Bifid scrotum (HP:0000048)1.63643258
139Mucopolysacchariduria (HP:0008155)1.62882578
140Urinary glycosaminoglycan excretion (HP:0003541)1.62882578
141Poikiloderma (HP:0001029)1.62826465
142Paralysis (HP:0003470)1.61728379
143Prostate neoplasm (HP:0100787)1.61702486
144Abnormal number of erythroid precursors (HP:0012131)1.61447674
145Hamartoma of the eye (HP:0010568)1.61070120
146Dehydration (HP:0001944)1.58399446
147Abnormality of monocarboxylic acid metabolism (HP:0010996)1.58396240
148Increased nuchal translucency (HP:0010880)1.57863226
149Facial hemangioma (HP:0000329)1.56900826
150Villous atrophy (HP:0011473)1.56869244
151Abnormality of small intestinal villus morphology (HP:0011472)1.56869244
152Coronal craniosynostosis (HP:0004440)1.55793295
153Distal upper limb amyotrophy (HP:0007149)1.55074840
154Upper limb amyotrophy (HP:0009129)1.55074840
155Oligodontia (HP:0000677)1.53014742
156Deep venous thrombosis (HP:0002625)1.50665379
157Multifactorial inheritance (HP:0001426)1.49202026
158Abnormally folded helix (HP:0008544)1.47929199
159Hypertensive crisis (HP:0100735)1.47000191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.58694660
2TYK23.74333751
3IRAK43.00115468
4MAPKAPK32.93240863
5LMTK22.73378487
6ICK2.63639186
7PIM22.62392587
8ERN12.54194707
9IRAK22.47700963
10TAOK22.28576409
11KIT2.24322206
12EEF2K2.20413334
13TEC2.19857020
14BTK2.18247785
15BMX2.12637181
16MAP3K62.10904905
17MST1R2.10639453
18MET2.08828190
19NME12.08614983
20TRPM71.97615532
21RPS6KB21.86143137
22CAMK1D1.85347189
23BLK1.81340005
24TBK11.75920163
25MAP3K91.74879941
26TAOK11.71088453
27ITK1.69429926
28RIPK11.67577602
29ZAP701.66649351
30MAP4K11.62809253
31MAP2K31.62445447
32MAP3K31.61276637
33MAP3K121.57815130
34RPS6KA41.52203844
35IKBKE1.50006797
36MAPKAPK51.49361304
37GRK71.46258340
38ERBB31.45234629
39SMG11.44377327
40IRAK31.43339566
41MAP3K141.41158738
42PIK3CG1.39233102
43STK241.38793306
44TYRO31.36648962
45JAK31.34313199
46PASK1.32925586
47CAMK1G1.32845582
48IRAK11.30157519
49NME21.28886095
50MST41.25988950
51NEK21.25713030
52TGFBR21.23841142
53PAK41.23026219
54PBK1.22339227
55HCK1.20343082
56VRK21.19972110
57STK161.19946737
58MAPK151.17901819
59EIF2AK11.16987923
60DYRK1B1.16690864
61LATS11.16531392
62IKBKB1.15050891
63WNK41.14262958
64ADRBK21.12962608
65SYK1.11482167
66CHEK21.11451489
67EPHA21.10129955
68JAK11.06093708
69EPHB21.05498089
70FLT31.04974061
71PLK41.03846581
72TGFBR11.00975927
73DDR21.00581921
74MARK20.99918357
75EPHB10.99649480
76CDK80.97800231
77TTN0.97740301
78DMPK0.92409085
79MAP2K60.92199259
80LRRK20.90404282
81CLK10.90109912
82MATK0.89787112
83CDK70.89115008
84FGFR10.88808451
85MAPKAPK20.88790277
86LATS20.87675391
87PDGFRA0.86307646
88BMPR1B0.85947324
89STK100.85132324
90CHUK0.84478565
91ATR0.84144194
92TNK20.81036528
93PKN20.80439995
94HIPK20.79674569
95SIK20.76984262
96PIM10.76277774
97BRSK20.74139649
98BUB10.73147925
99MTOR0.71938473
100DYRK30.71387758
101EPHA30.71038133
102FGR0.69243991
103JAK20.68996713
104FGFR40.68586091
105MAPK40.68471136
106BRSK10.68300870
107PRKCI0.67450936
108TRIB30.65552617
109SRPK10.65486037
110WNK10.64036338
111EIF2AK20.63414540
112TESK10.63131054
113CDK120.62923504
114LCK0.61187175
115RIPK40.61018141
116PTK20.60917548
117DYRK20.59785743
118MAP3K50.59590429
119SIK30.58523695
120CDC70.58496397
121MAP3K20.58464616
122RPS6KA20.58423347
123CDK40.55153655
124CDK60.55087261
125MAP3K80.54719565
126AURKA0.51489434
127MAP3K110.51282727
128AURKB0.51143314
129LYN0.49573185
130NLK0.48781827
131WEE10.48121309
132PRKG20.47573271
133CSF1R0.47170518
134TXK0.45831711
135TAF10.44701312
136RPS6KB10.44225179
137FES0.43310128
138MAPK110.42921867
139PLK10.42775182
140MAP3K10.41503474
141ARAF0.41320417
142FER0.39674720
143RPS6KC10.39099629
144RPS6KL10.39099629
145MAP3K100.38947921
146EGFR0.37336675
147TTK0.36811058
148YES10.36611041
149CDK30.36148907
150PTK60.35614727
151RPS6KA60.35553457
152MAPK30.35213204
153CHEK10.33036979
154CDK10.31567150
155STK30.30772531
156BCKDK0.28910388
157STK390.26888680
158PRKAA20.26104701
159MAP2K40.25898319
160CDC42BPA0.25828211
161CDK90.25094599
162ALK0.24894752
163CDK20.24651739
164CSNK1E0.23602551
165ATM0.21218547
166CDK11A0.20755545

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.30077280
2Fatty acid biosynthesis_Homo sapiens_hsa000613.22345431
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.88908616
4Sphingolipid metabolism_Homo sapiens_hsa006002.67501387
5Leishmaniasis_Homo sapiens_hsa051402.64214192
6Fructose and mannose metabolism_Homo sapiens_hsa000512.59286885
7Staphylococcus aureus infection_Homo sapiens_hsa051502.45338584
8Pertussis_Homo sapiens_hsa051332.44963468
9Ribosome_Homo sapiens_hsa030102.44925945
10Other glycan degradation_Homo sapiens_hsa005112.43825376
11p53 signaling pathway_Homo sapiens_hsa041152.26375321
12Protein export_Homo sapiens_hsa030602.25165085
13Arachidonic acid metabolism_Homo sapiens_hsa005902.12375137
14DNA replication_Homo sapiens_hsa030302.00574684
15Folate biosynthesis_Homo sapiens_hsa007901.98070697
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96978158
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92515414
18Biosynthesis of amino acids_Homo sapiens_hsa012301.89832841
19Legionellosis_Homo sapiens_hsa051341.89279002
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.79902099
21Galactose metabolism_Homo sapiens_hsa000521.71812968
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71705830
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71306756
24Toxoplasmosis_Homo sapiens_hsa051451.68231847
25Herpes simplex infection_Homo sapiens_hsa051681.68140559
26Osteoclast differentiation_Homo sapiens_hsa043801.61410610
27Hematopoietic cell lineage_Homo sapiens_hsa046401.51610652
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.51506011
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.51325815
30Linoleic acid metabolism_Homo sapiens_hsa005911.50418148
31Measles_Homo sapiens_hsa051621.47522119
32Fatty acid elongation_Homo sapiens_hsa000621.47370348
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.46540967
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45086651
35ABC transporters_Homo sapiens_hsa020101.44687829
36Platelet activation_Homo sapiens_hsa046111.41110079
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40748808
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.40706961
39Antigen processing and presentation_Homo sapiens_hsa046121.38902944
40Lysosome_Homo sapiens_hsa041421.38256630
41Pyruvate metabolism_Homo sapiens_hsa006201.37184100
42Histidine metabolism_Homo sapiens_hsa003401.36305404
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34709548
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33664401
45Tuberculosis_Homo sapiens_hsa051521.33535011
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33089194
47Pentose phosphate pathway_Homo sapiens_hsa000301.32280488
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30389482
49Primary immunodeficiency_Homo sapiens_hsa053401.27705421
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26698567
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26144462
52Apoptosis_Homo sapiens_hsa042101.25072260
53Influenza A_Homo sapiens_hsa051641.23973851
54Shigellosis_Homo sapiens_hsa051311.23096491
55Glutathione metabolism_Homo sapiens_hsa004801.22148365
56Caffeine metabolism_Homo sapiens_hsa002321.18911244
57Hepatitis C_Homo sapiens_hsa051601.17576448
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16474679
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14544529
60Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10716051
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.08697803
62B cell receptor signaling pathway_Homo sapiens_hsa046621.08378732
63Fatty acid metabolism_Homo sapiens_hsa012121.06411427
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.05888083
65Insulin signaling pathway_Homo sapiens_hsa049101.05682291
66Tyrosine metabolism_Homo sapiens_hsa003501.05522972
67Thyroid cancer_Homo sapiens_hsa052161.04733363
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03501073
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02686091
70Fanconi anemia pathway_Homo sapiens_hsa034601.01944202
71Carbon metabolism_Homo sapiens_hsa012001.00068294
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99249681
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.98675469
74Non-homologous end-joining_Homo sapiens_hsa034500.97070958
75Arginine biosynthesis_Homo sapiens_hsa002200.95600619
76Hepatitis B_Homo sapiens_hsa051610.95048152
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94854920
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94148624
79Bladder cancer_Homo sapiens_hsa052190.94022383
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91701293
81Ether lipid metabolism_Homo sapiens_hsa005650.91259684
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.90843514
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.89809262
84AMPK signaling pathway_Homo sapiens_hsa041520.89729403
85beta-Alanine metabolism_Homo sapiens_hsa004100.86865337
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86709099
87TNF signaling pathway_Homo sapiens_hsa046680.86574254
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85953915
89RNA transport_Homo sapiens_hsa030130.85934839
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.85023942
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.85014022
92Salmonella infection_Homo sapiens_hsa051320.83613118
93Chronic myeloid leukemia_Homo sapiens_hsa052200.83356973
94GnRH signaling pathway_Homo sapiens_hsa049120.83341955
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81442731
96VEGF signaling pathway_Homo sapiens_hsa043700.81428701
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81319801
98Starch and sucrose metabolism_Homo sapiens_hsa005000.79598643
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.77468048
100Acute myeloid leukemia_Homo sapiens_hsa052210.77337670
101Insulin resistance_Homo sapiens_hsa049310.75629768
102Malaria_Homo sapiens_hsa051440.75559512
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75130316
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74323507
105Phagosome_Homo sapiens_hsa041450.73882481
106Cell cycle_Homo sapiens_hsa041100.72873621
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72126502
108Spliceosome_Homo sapiens_hsa030400.71372194
109Axon guidance_Homo sapiens_hsa043600.71022896
110Epstein-Barr virus infection_Homo sapiens_hsa051690.70479461
111Basal cell carcinoma_Homo sapiens_hsa052170.70015080
112Base excision repair_Homo sapiens_hsa034100.69762475
113Retinol metabolism_Homo sapiens_hsa008300.68555846
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68493374
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66253304
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65615228
117Phenylalanine metabolism_Homo sapiens_hsa003600.65100354
118Pancreatic cancer_Homo sapiens_hsa052120.64581677
119Prolactin signaling pathway_Homo sapiens_hsa049170.63823951
120mRNA surveillance pathway_Homo sapiens_hsa030150.63811473
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63528784
122RNA degradation_Homo sapiens_hsa030180.62016983
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60016323
124Regulation of autophagy_Homo sapiens_hsa041400.59804611
125Fat digestion and absorption_Homo sapiens_hsa049750.59268505
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.58197460
127Chemokine signaling pathway_Homo sapiens_hsa040620.58128790
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57808394
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56873862
130Ovarian steroidogenesis_Homo sapiens_hsa049130.55430593
131Basal transcription factors_Homo sapiens_hsa030220.54188982
132Notch signaling pathway_Homo sapiens_hsa043300.54069201
133Oocyte meiosis_Homo sapiens_hsa041140.53765075
134Arginine and proline metabolism_Homo sapiens_hsa003300.53350277
135MicroRNAs in cancer_Homo sapiens_hsa052060.52900567
136Endocytosis_Homo sapiens_hsa041440.52799678
137Vitamin digestion and absorption_Homo sapiens_hsa049770.50040867
138Small cell lung cancer_Homo sapiens_hsa052220.49589763
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48579403
140Endometrial cancer_Homo sapiens_hsa052130.48348972
141N-Glycan biosynthesis_Homo sapiens_hsa005100.47587019
142HTLV-I infection_Homo sapiens_hsa051660.47382780
143ErbB signaling pathway_Homo sapiens_hsa040120.46923735
144Hippo signaling pathway_Homo sapiens_hsa043900.44605562
145Pyrimidine metabolism_Homo sapiens_hsa002400.44564277
146Mismatch repair_Homo sapiens_hsa034300.44422794
147RNA polymerase_Homo sapiens_hsa030200.43993979
148Nucleotide excision repair_Homo sapiens_hsa034200.43990156
149ECM-receptor interaction_Homo sapiens_hsa045120.43626599
150Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43405147
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43062767
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41486774
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.41285704
154FoxO signaling pathway_Homo sapiens_hsa040680.41195888
155T cell receptor signaling pathway_Homo sapiens_hsa046600.40749946
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40743754
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.40728430
158Sulfur relay system_Homo sapiens_hsa041220.40078981
159Adherens junction_Homo sapiens_hsa045200.39923704
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39312087
161Non-small cell lung cancer_Homo sapiens_hsa052230.39297830
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39255193
163Metabolic pathways_Homo sapiens_hsa011000.39044418
164Homologous recombination_Homo sapiens_hsa034400.37454610
165Vibrio cholerae infection_Homo sapiens_hsa051100.36385086
166Lysine degradation_Homo sapiens_hsa003100.35663552

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