VSIG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.38359777
2fusion of sperm to egg plasma membrane (GO:0007342)8.99937184
3response to pheromone (GO:0019236)8.64271534
4digestion (GO:0007586)8.06036499
5sperm motility (GO:0030317)7.96568499
6extracellular fibril organization (GO:0043206)7.23791137
7glutathione derivative metabolic process (GO:1901685)7.03789087
8glutathione derivative biosynthetic process (GO:1901687)7.03789087
9O-glycan processing (GO:0016266)6.86529634
10cell wall macromolecule metabolic process (GO:0044036)6.83715143
11cell wall macromolecule catabolic process (GO:0016998)6.83715143
12plasma membrane fusion (GO:0045026)6.71090789
13sperm-egg recognition (GO:0035036)6.32344545
14acrosome assembly (GO:0001675)6.17825693
15sulfation (GO:0051923)6.14150864
16fibril organization (GO:0097435)6.13635946
17multicellular organism reproduction (GO:0032504)6.09707507
18digestive system process (GO:0022600)6.09616962
19piRNA metabolic process (GO:0034587)5.94241818
20protein autoprocessing (GO:0016540)5.86489487
21spermatid development (GO:0007286)5.85337874
22binding of sperm to zona pellucida (GO:0007339)5.82684980
23regulation of proton transport (GO:0010155)5.74605468
24cell-cell recognition (GO:0009988)5.64789144
25cilium or flagellum-dependent cell motility (GO:0001539)5.54779736
26epithelial cilium movement (GO:0003351)5.45332563
27behavioral response to nicotine (GO:0035095)5.37005748
28response to iron ion (GO:0010039)5.36848024
29reproduction (GO:0000003)5.35830217
30synaptonemal complex organization (GO:0070193)5.35812678
31axonemal dynein complex assembly (GO:0070286)5.34419550
32synaptonemal complex assembly (GO:0007130)5.34151793
33motile cilium assembly (GO:0044458)5.22175595
34bundle of His cell to Purkinje myocyte communication (GO:0086069)5.14339794
35male meiosis (GO:0007140)5.10790349
363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.85760675
37purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.85760675
38protein O-linked glycosylation (GO:0006493)4.76603984
39negative regulation of digestive system process (GO:0060457)4.69957085
40regulation of phospholipase A2 activity (GO:0032429)4.52835703
41sperm capacitation (GO:0048240)4.41278812
42cilium movement (GO:0003341)4.39989894
43kidney morphogenesis (GO:0060993)4.20760992
44glandular epithelial cell differentiation (GO:0002067)4.20130922
45calcium ion-dependent exocytosis (GO:0017156)4.12649821
46single fertilization (GO:0007338)4.12220224
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.08107543
48phosphatidylserine acyl-chain remodeling (GO:0036150)4.06888615
49regulation of cilium movement (GO:0003352)4.03846317
50cellular response to arsenic-containing substance (GO:0071243)4.02279974
51DNA deamination (GO:0045006)3.90786073
52spermatogenesis (GO:0007283)3.89205728
53male gamete generation (GO:0048232)3.87306439
54fertilization (GO:0009566)3.81829564
55indolalkylamine metabolic process (GO:0006586)3.78545384
56kynurenine metabolic process (GO:0070189)3.78524928
57cellular ketone body metabolic process (GO:0046950)3.76685632
58tryptophan catabolic process (GO:0006569)3.76554939
59indole-containing compound catabolic process (GO:0042436)3.76554939
60indolalkylamine catabolic process (GO:0046218)3.76554939
61regulation of pH (GO:0006885)3.75741338
62fucose catabolic process (GO:0019317)3.71764734
63L-fucose metabolic process (GO:0042354)3.71764734
64L-fucose catabolic process (GO:0042355)3.71764734
65negative regulation of inclusion body assembly (GO:0090084)3.71099027
66DNA methylation involved in gamete generation (GO:0043046)3.69645604
67thyroid hormone metabolic process (GO:0042403)3.63751520
68seminiferous tubule development (GO:0072520)3.63197867
69germ cell development (GO:0007281)3.60942994
70production of molecular mediator of immune response (GO:0002440)3.59113017
71glutathione metabolic process (GO:0006749)3.58789886
72alditol phosphate metabolic process (GO:0052646)3.57322917
73intestinal absorption (GO:0050892)3.54692022
74gamete generation (GO:0007276)3.54630479
75cellular process involved in reproduction in multicellular organism (GO:0022412)3.51510411
76water-soluble vitamin biosynthetic process (GO:0042364)3.48788884
77chromosome condensation (GO:0030261)3.42696306
78phosphatidylserine metabolic process (GO:0006658)3.42209617
79organic cation transport (GO:0015695)3.40039858
80negative regulation of telomere maintenance (GO:0032205)3.36768040
81tryptophan metabolic process (GO:0006568)3.35021395
82sulfur amino acid catabolic process (GO:0000098)3.33354703
83glycerol ether metabolic process (GO:0006662)3.28814564
84thyroid hormone generation (GO:0006590)3.28677610
85regulation of inclusion body assembly (GO:0090083)3.28365410
86ketone body metabolic process (GO:1902224)3.28154794
87male meiosis I (GO:0007141)3.26724112
88chromosome organization involved in meiosis (GO:0070192)3.25361434
89intestinal epithelial cell development (GO:0060576)3.18988961
90phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.16099827
91DNA packaging (GO:0006323)3.10242013
92alditol metabolic process (GO:0019400)3.10022266
93leukotriene biosynthetic process (GO:0019370)3.09857227
94phospholipid scrambling (GO:0017121)3.07460763
95respiratory chain complex IV assembly (GO:0008535)3.06993746
96glycerol metabolic process (GO:0006071)3.04794899
97xenobiotic metabolic process (GO:0006805)3.04576119
98leukotriene metabolic process (GO:0006691)3.04509596
99protein polyglutamylation (GO:0018095)3.03960256
100phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.02711808
101arachidonic acid secretion (GO:0050482)3.01271514
102icosanoid secretion (GO:0032309)3.01271514
103genitalia morphogenesis (GO:0035112)3.00937239
104phosphatidylinositol acyl-chain remodeling (GO:0036149)2.99534080
105pH reduction (GO:0045851)2.99436088
106detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99230191
107chaperone-mediated protein complex assembly (GO:0051131)2.99218065
108ether metabolic process (GO:0018904)2.98785398
109regulation of meiosis I (GO:0060631)2.98454069
110diacylglycerol metabolic process (GO:0046339)2.97440320
111protein K11-linked deubiquitination (GO:0035871)2.95732438
112icosanoid transport (GO:0071715)2.95695115
113fatty acid derivative transport (GO:1901571)2.95695115
114preassembly of GPI anchor in ER membrane (GO:0016254)2.95686321
115indole-containing compound metabolic process (GO:0042430)2.93763361
116ventricular cardiac muscle cell action potential (GO:0086005)2.93106208
117meiotic nuclear division (GO:0007126)2.91797838
118detection of light stimulus involved in visual perception (GO:0050908)2.91714706
119detection of light stimulus involved in sensory perception (GO:0050962)2.91714706
120neural tube formation (GO:0001841)2.87418473
121regulation of regulatory T cell differentiation (GO:0045589)2.86106403
122gamma-aminobutyric acid transport (GO:0015812)2.85732342
123platelet dense granule organization (GO:0060155)2.84822906
124positive regulation of T cell differentiation in thymus (GO:0033089)2.81804171
125nephron tubule morphogenesis (GO:0072078)2.79416205
126nephron epithelium morphogenesis (GO:0072088)2.79416205
127basic amino acid transport (GO:0015802)2.79150465
128cytochrome complex assembly (GO:0017004)2.77803740
129primary amino compound metabolic process (GO:1901160)2.72995802
130activated T cell proliferation (GO:0050798)2.71906035
131adaptation of signaling pathway (GO:0023058)2.71496185
132axoneme assembly (GO:0035082)2.68911060
133somite development (GO:0061053)2.67749049
134amine catabolic process (GO:0009310)2.65153163
135cellular biogenic amine catabolic process (GO:0042402)2.65153163
136NAD biosynthetic process (GO:0009435)2.62057635
137positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61057780
138positive regulation of defense response to virus by host (GO:0002230)2.58970226
139mannosylation (GO:0097502)2.58064324
140regulation of mesoderm development (GO:2000380)2.55974330
141fucosylation (GO:0036065)2.55808390
142autophagic vacuole fusion (GO:0000046)2.55534742
143negative regulation of cAMP-mediated signaling (GO:0043951)2.55135053
144cAMP catabolic process (GO:0006198)2.53857659
145RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53213477
146photoreceptor cell maintenance (GO:0045494)2.48976486
147protein-cofactor linkage (GO:0018065)2.48719885
148S-adenosylmethionine metabolic process (GO:0046500)2.47405473
149phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47154869
150inositol phosphate dephosphorylation (GO:0046855)2.47154869
151cellular response to ATP (GO:0071318)2.46737267
152synaptic transmission, cholinergic (GO:0007271)2.44660398
153regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44193449
154regulation of T cell mediated cytotoxicity (GO:0001914)2.43731744
155ubiquinone biosynthetic process (GO:0006744)2.43495228
156regulation of memory T cell differentiation (GO:0043380)2.43494739
157inositol phosphate catabolic process (GO:0071545)2.43242010
158organelle membrane fusion (GO:0090174)2.42978464
159regulation of nuclear cell cycle DNA replication (GO:0033262)2.42278625
160negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41970791
161endoderm formation (GO:0001706)2.40635004
162reciprocal DNA recombination (GO:0035825)2.40297595
163reciprocal meiotic recombination (GO:0007131)2.40297595
164tolerance induction (GO:0002507)2.39738064
165spinal cord motor neuron differentiation (GO:0021522)2.39277046
166RNA destabilization (GO:0050779)2.38412298
167polyol catabolic process (GO:0046174)2.38322384
168regulation of hexokinase activity (GO:1903299)2.37808605
169regulation of glucokinase activity (GO:0033131)2.37808605
170antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36580563
171cellular response to exogenous dsRNA (GO:0071360)2.36432583
172rRNA catabolic process (GO:0016075)2.36315452
173serotonin metabolic process (GO:0042428)2.35477691
174head development (GO:0060322)2.35320383
175regulation of isotype switching to IgG isotypes (GO:0048302)2.35147749
176negative regulation of DNA-dependent DNA replication (GO:2000104)2.34838468
177cyclic nucleotide catabolic process (GO:0009214)2.34487977
178cytidine deamination (GO:0009972)2.33462936
179cytidine metabolic process (GO:0046087)2.33462936
180cytidine catabolic process (GO:0006216)2.33462936
181rhodopsin mediated signaling pathway (GO:0016056)2.32758250
182maintenance of gastrointestinal epithelium (GO:0030277)13.9735283
183epithelial structure maintenance (GO:0010669)10.4439472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.81395292
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.14418895
3SOX2_27498859_Chip-Seq_STOMACH_Mouse5.00916346
4ESR1_15608294_ChIP-ChIP_MCF-7_Human4.55917657
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.68329823
6* GATA4_25053715_ChIP-Seq_YYC3_Human2.47139788
7VDR_22108803_ChIP-Seq_LS180_Human2.43676189
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40211531
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.39479298
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.37980960
11GBX2_23144817_ChIP-Seq_PC3_Human2.31914243
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20622183
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.20304832
14ZNF274_21170338_ChIP-Seq_K562_Hela2.16503277
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.14853902
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04250142
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.02725127
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96143819
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.94678919
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.91493433
21ER_23166858_ChIP-Seq_MCF-7_Human1.90759586
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90488992
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89355213
24GATA6_25053715_ChIP-Seq_YYC3_Human1.89331423
25IGF1R_20145208_ChIP-Seq_DFB_Human1.89016072
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85697610
27P300_19829295_ChIP-Seq_ESCs_Human1.81219899
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78927507
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78885996
30FUS_26573619_Chip-Seq_HEK293_Human1.77482289
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76844007
32EWS_26573619_Chip-Seq_HEK293_Human1.71118850
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70729092
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69974469
35AHR_22903824_ChIP-Seq_MCF-7_Human1.69093481
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.68736816
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65453531
38KLF5_25053715_ChIP-Seq_YYC3_Human1.63353552
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62537955
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61492571
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.56537487
42STAT1_20625510_ChIP-Seq_HELA_Human1.54543069
43IRF1_19129219_ChIP-ChIP_H3396_Human1.54290742
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54158378
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.54158378
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52387735
47AR_25329375_ChIP-Seq_VCAP_Human1.48447567
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47315473
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.46429042
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.45970858
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45628040
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.43719991
53TP53_22573176_ChIP-Seq_HFKS_Human1.43246523
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42580840
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42395641
56TAF15_26573619_Chip-Seq_HEK293_Human1.41929740
57MYC_18940864_ChIP-ChIP_HL60_Human1.41332317
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40625552
59GATA3_26560356_Chip-Seq_TH2_Human1.40312513
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40222517
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39090804
62RAD21_21589869_ChIP-Seq_MESCs_Mouse1.36619510
63NANOG_19829295_ChIP-Seq_ESCs_Human1.36500724
64SOX2_19829295_ChIP-Seq_ESCs_Human1.36500724
65P53_21459846_ChIP-Seq_SAOS-2_Human1.36180229
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35695408
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32732089
68FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30418687
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.30061173
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.30013100
71AR_20517297_ChIP-Seq_VCAP_Human1.29729960
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29383024
73STAT3_23295773_ChIP-Seq_U87_Human1.29234304
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29131922
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.27510026
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26635217
77* TCF4_23295773_ChIP-Seq_U87_Human1.25699124
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.25603964
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.25455675
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25245014
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25245014
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24116139
83* SOX2_20726797_ChIP-Seq_SW620_Human1.24063706
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23988906
85ZNF263_19887448_ChIP-Seq_K562_Human1.23837082
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.23612283
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23456818
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23374871
89* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23004095
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22854914
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21837610
92TCF4_22108803_ChIP-Seq_LS180_Human1.21733243
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21520757
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.21230189
95HOXB7_26014856_ChIP-Seq_BT474_Human1.21001201
96BCAT_22108803_ChIP-Seq_LS180_Human1.20786989
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.20449875
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19552031
99CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19503528
100ELK4_26923725_Chip-Seq_MESODERM_Mouse1.18284379
101NCOR_22424771_ChIP-Seq_293T_Human1.17996888
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17732600
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16604107
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15662829
105CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15188206
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15155564
107SMAD4_21799915_ChIP-Seq_A2780_Human1.15041407
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14058809
109KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13926593
110ERA_21632823_ChIP-Seq_H3396_Human1.13537267
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13272328
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13204660
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13204660
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12761705
115NANOG_20526341_ChIP-Seq_ESCs_Human1.12304928
116RUNX2_22187159_ChIP-Seq_PCA_Human1.11754605
117EZH2_22144423_ChIP-Seq_EOC_Human1.10808496
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10400183
119LXR_22292898_ChIP-Seq_THP-1_Human1.10154929
120GATA3_24758297_ChIP-Seq_MCF-7_Human1.10026487
121PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09563339
122MYC_19829295_ChIP-Seq_ESCs_Human1.09035298
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08926436
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.08896715
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08747917
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08200272
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08168535
128FOXA2_19822575_ChIP-Seq_HepG2_Human1.08105952
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07827819
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.07535623
131CBP_20019798_ChIP-Seq_JUKART_Human1.07291081
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07291081
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06619431
134AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06374768
135ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06352379
136GATA1_26923725_Chip-Seq_HPCs_Mouse1.06347647
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06282069
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.05863511
139GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04931335
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04539530
141REST_21632747_ChIP-Seq_MESCs_Mouse1.04467284
142TAF2_19829295_ChIP-Seq_ESCs_Human1.03961118
143EGR1_19032775_ChIP-ChIP_M12_Human1.03663571
144ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03441127
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.02849205
146TCF4_18268006_ChIP-ChIP_LS174T_Human1.02302705
147P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01587898
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01414276
149TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99499065
150P53_22387025_ChIP-Seq_ESCs_Mouse0.98958606
151EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98887926
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98802260
153BCOR_27268052_Chip-Seq_Bcells_Human0.98482966
154VDR_23849224_ChIP-Seq_CD4+_Human0.97228071
155FOXH1_21741376_ChIP-Seq_EPCs_Human0.96801864
156CDX2_22108803_ChIP-Seq_LS180_Human0.95229660
157FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94996901
158Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94561073
159RUNX_20019798_ChIP-Seq_JUKART_Human0.93330315
160* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93198234
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93145762
162CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92303477
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.91755275
164CDX2_20551321_ChIP-Seq_CACO-2_Human0.91476216
165TP63_22573176_ChIP-Seq_HFKS_Human0.90650892
166P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89734841
167SOX2_22085726_ChIP-Seq_NPCs_Mouse0.89414020
168PHF8_20622854_ChIP-Seq_HELA_Human0.88802486
169TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86283076
170STAT1_17558387_ChIP-Seq_HELA_Human0.86108394
171TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84654835
172RACK7_27058665_Chip-Seq_MCF-7_Human0.84107861
173CJUN_26792858_Chip-Seq_BT549_Human0.83801238
174SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82977406
175STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81392728
176SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80040680
177SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.79417403
178TRIM28_21343339_ChIP-Seq_HEK293_Human0.79288741
179PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77913569
180* TBX20_22328084_ChIP-Seq_HEART_Mouse0.75695752
181* TBX20_22080862_ChIP-Seq_HEART_Mouse0.75695752
182CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75579499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation5.57217725
2MP0001664_abnormal_digestion4.93220014
3MP0005410_abnormal_fertilization4.51012677
4MP0000470_abnormal_stomach_morphology3.90529287
5MP0001986_abnormal_taste_sensitivity3.10121704
6MP0003195_calcinosis3.09706654
7MP0003806_abnormal_nucleotide_metabolis2.85816031
8MP0008872_abnormal_physiological_respon2.53683559
9MP0002138_abnormal_hepatobiliary_system2.32722696
10MP0005084_abnormal_gallbladder_morpholo2.15059743
11MP0005551_abnormal_eye_electrophysiolog2.09823318
12MP0010234_abnormal_vibrissa_follicle2.08768884
13MP0003787_abnormal_imprinting2.02440955
14MP0008004_abnormal_stomach_pH16.4846175
15MP0006072_abnormal_retinal_apoptosis1.99831904
16MP0002876_abnormal_thyroid_physiology1.97877996
17MP0001663_abnormal_digestive_system1.96256388
18MP0001968_abnormal_touch/_nociception1.91455802
19MP0002102_abnormal_ear_morphology1.87559391
20MP0001666_abnormal_nutrient_absorption1.77929987
21MP0002928_abnormal_bile_duct1.75604137
22MP0005381_digestive/alimentary_phenotyp1.73461324
23MP0002837_dystrophic_cardiac_calcinosis1.72161958
24MP0002277_abnormal_respiratory_mucosa1.71285863
25MP0005253_abnormal_eye_physiology1.70613681
26MP0003724_increased_susceptibility_to1.69024878
27MP0003698_abnormal_male_reproductive1.67550117
28MP0005645_abnormal_hypothalamus_physiol1.66380831
29MP0005671_abnormal_response_to1.64291502
30MP0003011_delayed_dark_adaptation1.61689859
31MP0000427_abnormal_hair_cycle1.58757756
32MP0003646_muscle_fatigue1.58736002
33MP0001929_abnormal_gametogenesis1.58500207
34MP0001501_abnormal_sleep_pattern1.58155990
35MP0000537_abnormal_urethra_morphology1.55703235
36MP0004142_abnormal_muscle_tone1.52508045
37MP0004264_abnormal_extraembryonic_tissu1.51885501
38MP0001485_abnormal_pinna_reflex1.50562179
39MP0008877_abnormal_DNA_methylation1.49300898
40MP0002163_abnormal_gland_morphology1.48108768
41MP0002938_white_spotting1.47509770
42MP0009745_abnormal_behavioral_response1.46275567
43MP0000372_irregular_coat_pigmentation1.44340647
44MP0004885_abnormal_endolymph1.41466732
45MP0005165_increased_susceptibility_to1.37745446
46MP0003283_abnormal_digestive_organ1.36561782
47MP0005646_abnormal_pituitary_gland1.29717426
48MP0003136_yellow_coat_color1.28761170
49MP0000230_abnormal_systemic_arterial1.26388304
50MP0004742_abnormal_vestibular_system1.25569484
51MP0001800_abnormal_humoral_immune1.24074673
52MP0000569_abnormal_digit_pigmentation1.23961385
53MP0000477_abnormal_intestine_morphology1.23146656
54MP0003252_abnormal_bile_duct1.22024289
55MP0002736_abnormal_nociception_after1.19691042
56MP0005379_endocrine/exocrine_gland_phen1.19003306
57MP0006292_abnormal_olfactory_placode1.18571814
58MP0000685_abnormal_immune_system1.18043318
59MP0002638_abnormal_pupillary_reflex1.17546585
60MP0005083_abnormal_biliary_tract1.15954433
61MP0006054_spinal_hemorrhage1.15496921
62MP0002272_abnormal_nervous_system1.13111455
63MP0005389_reproductive_system_phenotype1.11900537
64MP0006276_abnormal_autonomic_nervous1.11723612
65MP0010386_abnormal_urinary_bladder1.10611287
66MP0005174_abnormal_tail_pigmentation1.07745475
67MP0000462_abnormal_digestive_system1.07571873
68MP0009764_decreased_sensitivity_to1.07491912
69MP0009046_muscle_twitch1.07430286
70MP0002210_abnormal_sex_determination1.05021114
71MP0002733_abnormal_thermal_nociception1.03389798
72MP0002572_abnormal_emotion/affect_behav1.02457230
73MP0005075_abnormal_melanosome_morpholog1.01082904
74MP0005387_immune_system_phenotype1.00432368
75MP0001790_abnormal_immune_system1.00432368
76MP0003638_abnormal_response/metabolism_0.99938397
77MP0001919_abnormal_reproductive_system0.99307522
78MP0002148_abnormal_hypersensitivity_rea0.98615747
79MP0001970_abnormal_pain_threshold0.98003040
80MP0004133_heterotaxia0.96402991
81MP0002557_abnormal_social/conspecific_i0.95710454
82MP0002234_abnormal_pharynx_morphology0.95387677
83MP0002723_abnormal_immune_serum0.95366791
84MP0001145_abnormal_male_reproductive0.93661501
85MP0003705_abnormal_hypodermis_morpholog0.92013788
86MP0002161_abnormal_fertility/fecundity0.91515594
87MP0009785_altered_susceptibility_to0.89339066
88MP0000631_abnormal_neuroendocrine_gland0.89205626
89MP0001486_abnormal_startle_reflex0.87623953
90MP0009384_cardiac_valve_regurgitation0.86650333
91MP0000538_abnormal_urinary_bladder0.85462316
92MP0004147_increased_porphyrin_level0.84577188
93MP0002064_seizures0.82334776
94MP0005332_abnormal_amino_acid0.81392093
95MP0001764_abnormal_homeostasis0.81289792
96MP0004145_abnormal_muscle_electrophysio0.80900095
97MP0005195_abnormal_posterior_eye0.78825586
98MP0000653_abnormal_sex_gland0.78071286
99MP0002452_abnormal_antigen_presenting0.76124150
100MP0008775_abnormal_heart_ventricle0.75259865
101MP0000490_abnormal_crypts_of0.73894829
102MP0003868_abnormal_feces_composition0.73887681
103MP0002909_abnormal_adrenal_gland0.73861085
104MP0004215_abnormal_myocardial_fiber0.73783276
105MP0002067_abnormal_sensory_capabilities0.73745783
106MP0002420_abnormal_adaptive_immunity0.73469524
107MP0008995_early_reproductive_senescence0.73414573
108MP0005636_abnormal_mineral_homeostasis0.72682232
109MP0005085_abnormal_gallbladder_physiolo0.70996603
110MP0003186_abnormal_redox_activity0.70421171
111MP0005670_abnormal_white_adipose0.66295120
112MP0003866_abnormal_defecation0.64351155
113MP0005377_hearing/vestibular/ear_phenot0.63589394
114MP0003878_abnormal_ear_physiology0.63589394
115MP0004185_abnormal_adipocyte_glucose0.63208678
116MP0002796_impaired_skin_barrier0.62407966
117MP0001849_ear_inflammation0.62218099
118MP0005266_abnormal_metabolism0.60080463
119MP0010329_abnormal_lipoprotein_level0.56710799
120MP0008875_abnormal_xenobiotic_pharmacok0.55239319
121MP0005623_abnormal_meninges_morphology0.53634970
122MP0010155_abnormal_intestine_physiology0.52956780
123MP0002877_abnormal_melanocyte_morpholog0.51077475
124MP0004947_skin_inflammation0.49791722
125MP0000467_abnormal_esophagus_morphology0.48793478
126MP0005365_abnormal_bile_salt0.47215577
127MP0003115_abnormal_respiratory_system0.45870245
128MP0004484_altered_response_of0.44725438
129MP0010352_gastrointestinal_tract_polyps0.44390142
130MP0001765_abnormal_ion_homeostasis0.44055487
131MP0002009_preneoplasia0.43050007
132MP0003119_abnormal_digestive_system0.42876514
133MP0003329_amyloid_beta_deposits0.42125783
134MP0003953_abnormal_hormone_level0.41747281
135MP0001216_abnormal_epidermal_layer0.40410414
136MP0003045_fibrosis0.39608959
137MP0005666_abnormal_adipose_tissue0.38299481
138MP0002019_abnormal_tumor_incidence0.37646770
139MP0005076_abnormal_cell_differentiation0.35904594
140MP0010678_abnormal_skin_adnexa0.34929513
141MP0003315_abnormal_perineum_morphology0.34682821
142MP0005647_abnormal_sex_gland0.34614801
143MP0002118_abnormal_lipid_homeostasis0.32317406
144MP0002139_abnormal_hepatobiliary_system0.31796187
145MP0003566_abnormal_cell_adhesion0.31140418
146MP0002060_abnormal_skin_morphology0.31137385
147MP0001243_abnormal_dermal_layer0.30582119
148MP0002282_abnormal_trachea_morphology0.30415860
149MP0005408_hypopigmentation0.30051521
150MP0002970_abnormal_white_adipose0.29821066
151MP0001727_abnormal_embryo_implantation0.28695244
152MP0005167_abnormal_blood-brain_barrier0.28688838
153MP0002653_abnormal_ependyma_morphology0.28428258
154MP0008961_abnormal_basal_metabolism0.27950130
155MP0003936_abnormal_reproductive_system0.27335821
156MP0002160_abnormal_reproductive_system0.26689381
157MP0005166_decreased_susceptibility_to0.25872741
158MP0001661_extended_life_span0.25362815
159MP0005319_abnormal_enzyme/_coenzyme0.25136348
160MP0000013_abnormal_adipose_tissue0.24765537
161MP0004858_abnormal_nervous_system0.24117055
162MP0005501_abnormal_skin_physiology0.24002603
163MP0004043_abnormal_pH_regulation0.23979619
164MP0003453_abnormal_keratinocyte_physiol0.22998265
165MP0008873_increased_physiological_sensi0.22519181
166MP0003075_altered_response_to0.22250486
167MP0002693_abnormal_pancreas_physiology0.21975056
168MP0004019_abnormal_vitamin_homeostasis0.21554911
169MP0004233_abnormal_muscle_weight0.21416034
170MP0002078_abnormal_glucose_homeostasis0.20494134
171MP0009642_abnormal_blood_homeostasis0.20468873
172MP0000609_abnormal_liver_physiology0.20036773
173MP0005310_abnormal_salivary_gland0.19025347
174MP0000604_amyloidosis0.19018632
175MP0000598_abnormal_liver_morphology0.18295922

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.76883169
2Absent/shortened dynein arms (HP:0200106)8.76883169
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.47763394
4Abnormal number of erythroid precursors (HP:0012131)8.20290250
5Abnormality of cells of the erythroid lineage (HP:0012130)7.22868370
6Right ventricular cardiomyopathy (HP:0011663)6.40064788
7Chronic bronchitis (HP:0004469)5.81765505
8Abnormal respiratory motile cilium physiology (HP:0012261)5.75898422
9Abnormal respiratory motile cilium morphology (HP:0005938)5.49493428
10Abnormal respiratory epithelium morphology (HP:0012253)5.49493428
11Male infertility (HP:0003251)4.96452060
12Infertility (HP:0000789)4.89098236
13Rhinitis (HP:0012384)4.60350953
14Nasal polyposis (HP:0100582)4.49465806
15Pancreatic cysts (HP:0001737)4.34551130
16Abnormal ciliary motility (HP:0012262)4.30695760
17Congenital stationary night blindness (HP:0007642)4.06226051
18Tubulointerstitial nephritis (HP:0001970)3.99034755
19Pancreatic fibrosis (HP:0100732)3.96413016
20Abnormality of midbrain morphology (HP:0002418)3.80727969
21Molar tooth sign on MRI (HP:0002419)3.80727969
22True hermaphroditism (HP:0010459)3.75411522
23Abnormality of the nasal mucosa (HP:0000433)3.69893127
24Abnormality of the vitamin B12 metabolism (HP:0004341)3.69849019
25Megaloblastic anemia (HP:0001889)3.61364409
26Tubular atrophy (HP:0000092)3.45958810
27Abnormality of vitamin B metabolism (HP:0004340)3.43900138
28Bronchitis (HP:0012387)3.33098710
29Attenuation of retinal blood vessels (HP:0007843)3.32553609
30Type II lissencephaly (HP:0007260)3.19004412
31Chronic hepatic failure (HP:0100626)3.11772160
32Abnormal drinking behavior (HP:0030082)3.08986301
33Polydipsia (HP:0001959)3.08986301
34Gonadotropin excess (HP:0000837)3.05120422
35Abolished electroretinogram (ERG) (HP:0000550)3.04496516
36Abnormality of vitamin metabolism (HP:0100508)3.00994283
37Large for gestational age (HP:0001520)2.95904072
38Pendular nystagmus (HP:0012043)2.94317004
39Tubulointerstitial fibrosis (HP:0005576)2.92369541
40Goiter (HP:0000853)2.90978030
41Bronchiectasis (HP:0002110)2.87528228
42Micronodular cirrhosis (HP:0001413)2.81309851
43Gout (HP:0001997)2.80521416
44Palpitations (HP:0001962)2.79568456
45Flat acetabular roof (HP:0003180)2.76779166
46Hemorrhage of the eye (HP:0011885)2.76653897
47Abnormal spermatogenesis (HP:0008669)2.75109700
48Congenital, generalized hypertrichosis (HP:0004540)2.73038223
49Stomatitis (HP:0010280)2.71768415
50Ventricular fibrillation (HP:0001663)2.70875830
51Progressive inability to walk (HP:0002505)2.69746734
52Inability to walk (HP:0002540)2.67702342
53Woolly hair (HP:0002224)2.65146558
54Abnormal rod and cone electroretinograms (HP:0008323)2.64054840
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61398998
56Abnormality of alanine metabolism (HP:0010916)2.61398998
57Hyperalaninemia (HP:0003348)2.61398998
58Cystic liver disease (HP:0006706)2.61371858
59Polyuria (HP:0000103)2.57029882
60Stomach cancer (HP:0012126)2.53750432
61Syncope (HP:0001279)2.52338290
62Abnormality of macular pigmentation (HP:0008002)2.50908544
63Tubulointerstitial abnormality (HP:0001969)2.50726062
64Hyperventilation (HP:0002883)2.50494299
65Vascular calcification (HP:0004934)2.50433801
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49685462
67Furrowed tongue (HP:0000221)2.41479362
68Decreased circulating renin level (HP:0003351)2.40980453
69Bilateral microphthalmos (HP:0007633)2.40693444
70Glomerulosclerosis (HP:0000096)2.37862537
71Milia (HP:0001056)2.33758933
72Spastic tetraparesis (HP:0001285)2.33165104
73Facial diplegia (HP:0001349)2.32052293
74Hyperuricemia (HP:0002149)2.27863186
75Increased purine levels (HP:0004368)2.27863186
76Cardiovascular calcification (HP:0011915)2.27777100
77Sclerocornea (HP:0000647)2.25116359
78Decreased central vision (HP:0007663)2.25074032
79Abnormality of purine metabolism (HP:0004352)2.23646247
80Azoospermia (HP:0000027)2.20973230
81Frequent falls (HP:0002359)2.13281202
82Medial flaring of the eyebrow (HP:0010747)2.12575141
83Abnormal urine output (HP:0012590)2.11090091
84Bony spicule pigmentary retinopathy (HP:0007737)2.09853877
85Hemiparesis (HP:0001269)2.09669115
86Focal segmental glomerulosclerosis (HP:0000097)2.09185194
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.09055097
88Abnormal gallbladder physiology (HP:0012438)2.09042246
89Cholecystitis (HP:0001082)2.09042246
90Ketoacidosis (HP:0001993)2.08635482
91Cone-rod dystrophy (HP:0000548)2.08258182
92Increased corneal curvature (HP:0100692)2.08193373
93Keratoconus (HP:0000563)2.08193373
94Ketosis (HP:0001946)2.08091259
95Recurrent otitis media (HP:0000403)2.07660033
96Gonadal dysgenesis (HP:0000133)2.07419009
97Stage 5 chronic kidney disease (HP:0003774)2.07204358
98Abnormality of the gastric mucosa (HP:0004295)2.06339577
99Chorioretinal atrophy (HP:0000533)2.05975926
100Congenital hepatic fibrosis (HP:0002612)2.05765964
101Abnormality of the renal medulla (HP:0100957)2.05498365
102Bone cyst (HP:0012062)2.04704205
103Nephronophthisis (HP:0000090)2.04578743
104Choroideremia (HP:0001139)2.01983075
105Abnormality of the renal cortex (HP:0011035)2.01682681
106Abnormal biliary tract physiology (HP:0012439)2.01053389
107Bile duct proliferation (HP:0001408)2.01053389
108Germ cell neoplasia (HP:0100728)2.00008448
109Hypothermia (HP:0002045)2.00003762
110Elevated erythrocyte sedimentation rate (HP:0003565)1.98351028
111Hand muscle atrophy (HP:0009130)1.98348507
112Breast carcinoma (HP:0003002)1.95027617
113Back pain (HP:0003418)1.94692685
114Abnormality of the pons (HP:0007361)1.93475262
115Testicular neoplasm (HP:0010788)1.92024282
116Male pseudohermaphroditism (HP:0000037)1.91825526
117Amelogenesis imperfecta (HP:0000705)1.90004588
118Concave nail (HP:0001598)1.89962356
119IgG deficiency (HP:0004315)1.89625748
120Hypoplasia of dental enamel (HP:0006297)1.89403146
121Hypoalbuminemia (HP:0003073)1.87952559
122Abnormal albumin level (HP:0012116)1.87952559
123Anencephaly (HP:0002323)1.87892614
124Thyroiditis (HP:0100646)1.86591966
125Lissencephaly (HP:0001339)1.85558626
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85434504
127Cerebellar dysplasia (HP:0007033)1.84379456
128Clumsiness (HP:0002312)1.84043623
129Severe visual impairment (HP:0001141)1.83809541
130Aplasia/hypoplasia of the uterus (HP:0008684)1.83464151
131Abnormality of the lower motor neuron (HP:0002366)1.83081982
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.81606299
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.81277863
134Flattened epiphyses (HP:0003071)1.81027073
135Atrophic scars (HP:0001075)1.80028592
136Rectal prolapse (HP:0002035)1.79652291
137Renal cortical cysts (HP:0000803)1.79382938
138Recurrent sinusitis (HP:0011108)1.79301513
139Hypoplasia of the pons (HP:0012110)1.78597766
140Hematochezia (HP:0002573)1.78296385
141Bundle branch block (HP:0011710)1.78223749
142Macular degeneration (HP:0000608)1.77833661
143Ventricular arrhythmia (HP:0004308)1.77665957
144Abdominal distention (HP:0003270)1.77323850
145Hypoplasia of the uterus (HP:0000013)1.76756076
146Fair hair (HP:0002286)1.75395374
147Severe muscular hypotonia (HP:0006829)1.75392712
148Metaphyseal cupping (HP:0003021)1.75330514
149Hypomagnesemia (HP:0002917)1.73781524
150Tongue fasciculations (HP:0001308)1.73687086
151Abnormal delayed hypersensitivity skin test (HP:0002963)1.72616627
152Hypoplasia of the fovea (HP:0007750)1.72446285
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.72446285
154Progressive cerebellar ataxia (HP:0002073)1.72177537
155Constricted visual fields (HP:0001133)1.71258781
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71055475
157Gaze-evoked nystagmus (HP:0000640)1.70830306
158Arterial tortuosity (HP:0005116)1.70477058
159Genetic anticipation (HP:0003743)1.69410410
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.68255167
161Intrahepatic cholestasis (HP:0001406)1.68028068
162Optic disc pallor (HP:0000543)1.67338792
163Recurrent bronchitis (HP:0002837)1.67320846
164Panhypogammaglobulinemia (HP:0003139)1.66831810
165Retinal dysplasia (HP:0007973)1.66422315
166Tachypnea (HP:0002789)1.65220894
167Aortic dissection (HP:0002647)1.64914131
168Short tibia (HP:0005736)1.63359796
16911 pairs of ribs (HP:0000878)1.62925187
170Ankyloglossia (HP:0010296)1.62575896
171Aplasia/Hypoplasia of the patella (HP:0006498)1.62276924
172Upper limb amyotrophy (HP:0009129)1.61580353
173Distal upper limb amyotrophy (HP:0007149)1.61580353
174Abnormality of renal excretion (HP:0011036)1.59707937
175Hypoalphalipoproteinemia (HP:0003233)1.57022047
176Plantar hyperkeratosis (HP:0007556)1.56595853
177Aortic aneurysm (HP:0004942)1.55663159
178Fragile skin (HP:0001030)1.54272041
179Muscle fibrillation (HP:0010546)1.54235065
180Abnormality of chloride homeostasis (HP:0011422)1.54148127
181Stridor (HP:0010307)1.53599326
182Malnutrition (HP:0004395)1.52932252
183Fragile nails (HP:0001808)1.50989948
184Hyporeflexia of lower limbs (HP:0002600)1.46920209
185Ventricular tachycardia (HP:0004756)1.45461495
186Vascular tortuosity (HP:0004948)1.45332932
187Osteolytic defects of the phalanges of the hand (HP:0009771)1.44508876
188Osteolytic defects of the hand bones (HP:0009699)1.44508876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB48.99388036
2PDK35.25793896
3PDK45.25793896
4MST44.31291194
5TESK13.90832351
6BMPR1B3.73268793
7ACVR1B3.42434624
8PDK23.37344873
9MST1R3.36404360
10ADRBK23.30691678
11TAOK33.27269892
12ICK2.97505928
13PRKD32.58708092
14WNK32.39306676
15GRK12.27800173
16TLK12.27322968
17TRIB32.15522351
18ZAK2.15327610
19INSRR2.06681614
20MAPK151.96011866
21STK391.92908055
22DAPK21.90704230
23WNK41.89725701
24MAP4K21.88108723
25TXK1.86694346
26PKN21.72949117
27PINK11.72596775
28TGFBR11.67410259
29MET1.48063082
30CASK1.47425689
31OXSR11.47212152
32LMTK21.42336626
33CAMKK21.40664614
34ADRBK11.39566951
35STK101.33268794
36LRRK21.30110509
37MAP4K11.24082138
38PTK61.23807798
39TIE11.22624355
40MAP2K21.21576522
41PTK2B1.19266647
42ITK1.18614675
43MAPK131.10201358
44MAP3K21.10017010
45MAP3K41.08452168
46TEC1.07237158
47TYRO31.02337148
48FER1.02122650
49RIPK40.99760333
50IKBKB0.98349849
51PRKG20.96266113
52PAK40.96239589
53TSSK60.93587690
54EPHA20.92885611
55MYLK0.90937001
56MKNK20.90290627
57MAP2K10.89296688
58PLK20.88974746
59RIPK10.88581933
60EEF2K0.88163075
61PLK40.87783968
62FRK0.86807896
63GRK60.84838708
64KSR20.83552214
65FGFR20.82410614
66NLK0.81745221
67DYRK1B0.80941570
68TRPM70.80583663
69PIK3CG0.79784094
70NUAK10.79737240
71PRKCE0.75848470
72CDK80.75715545
73IKBKE0.74104603
74TRIM280.73633492
75VRK10.73440040
76PDK10.73307344
77TNIK0.71033262
78WNK10.70602924
79PDGFRB0.69907771
80SYK0.68009102
81PRKCG0.67733215
82PHKG10.66507690
83PHKG20.66507690
84IRAK10.65818789
85PIK3CA0.64128803
86NEK20.64021446
87RPS6KA50.63421759
88LCK0.62474795
89PRKCI0.62448036
90DYRK20.61384678
91MAP3K90.61232809
92IRAK40.59295976
93KIT0.59036941
94PTK20.58388734
95PDPK10.57896376
96ERBB30.57152376
97EIF2AK30.54563849
98STK380.53692586
99SIK20.52848155
100CDK90.52805648
101LATS10.52188622
102ERN10.52137846
103MAP3K100.52105471
104MAPKAPK30.51903918
105STK30.50879661
106STK110.50709538
107WEE10.50417446
108TTN0.50212822
109PAK30.50067366
110CHUK0.49074663
111TNK20.47829092
112ZAP700.47574550
113PAK20.47058799
114FYN0.46845363
115EPHB10.46483893
116LYN0.44707740
117DDR20.44046884
118PAK10.43939906
119RPS6KA60.43435517
120IGF1R0.42795646
121MAP3K80.41140110
122BMX0.40651091
123BRSK20.40071590
124CAMK2A0.38082430
125BTK0.37006476
126LIMK10.36778323
127PNCK0.36581291
128ROCK20.36137266
129SRC0.35893785
130ERBB20.35853633
131MAP2K70.35199860
132MAPKAPK50.35180728
133TAOK10.35010744
134MAP2K60.34479385
135GRK70.33402762
136PLK30.33007834
137CSNK1G10.31138643
138ABL10.31060596
139CDK120.30541188
140ROCK10.29831656
141PRKACA0.29739073
142NTRK30.29708416
143PASK0.29569482
144MARK30.29490115
145EGFR0.29439074
146MUSK0.29224825
147PRKCA0.28652364
148CSNK1G20.27380523
149MKNK10.26430387
150CDK60.25844668
151NEK10.25685190
152RPS6KA20.22523971
153RPS6KB20.22432469
154CAMKK10.21184349
155PDGFRA0.20890054
156DMPK0.20838715
157MTOR0.18323831
158RET0.16888880
159BCKDK0.16591001
160MAP3K30.15430054
161CSK0.14326166
162STK38L0.14309010
163EPHB20.14052025
164MAP3K10.13027916
165RPS6KA10.12964448
166AURKB0.12735965
167CAMK2D0.11490421
168CDK70.11232947
169TESK20.10732366
170PRKCQ0.10133493
171CAMK2B0.09782298
172CDC42BPA0.09343946
173NME10.07998106
174MATK0.07263959
175AKT20.07020294
176NTRK10.06289474
177CDK40.05515475
178PRKAA10.05116095

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.84541519
2Gastric acid secretion_Homo sapiens_hsa049714.42275172
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.26580335
4Sulfur metabolism_Homo sapiens_hsa009204.17475513
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.92179843
6Collecting duct acid secretion_Homo sapiens_hsa049663.84412750
7Chemical carcinogenesis_Homo sapiens_hsa052043.48933174
8Glutathione metabolism_Homo sapiens_hsa004803.28792367
9Fat digestion and absorption_Homo sapiens_hsa049752.71259041
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71215542
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.58489777
12Linoleic acid metabolism_Homo sapiens_hsa005912.41062356
13Phototransduction_Homo sapiens_hsa047442.28219591
14Vitamin digestion and absorption_Homo sapiens_hsa049772.13962662
15Mineral absorption_Homo sapiens_hsa049782.09563802
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.08235777
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08095055
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04271929
19Pyruvate metabolism_Homo sapiens_hsa006201.95513969
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95106779
21Allograft rejection_Homo sapiens_hsa053301.90387401
22Type I diabetes mellitus_Homo sapiens_hsa049401.86975001
23Caffeine metabolism_Homo sapiens_hsa002321.86429657
24Asthma_Homo sapiens_hsa053101.79461153
25Autoimmune thyroid disease_Homo sapiens_hsa053201.77772592
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75794469
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74808915
28Primary immunodeficiency_Homo sapiens_hsa053401.69501710
29Tryptophan metabolism_Homo sapiens_hsa003801.64802379
30Graft-versus-host disease_Homo sapiens_hsa053321.64150750
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61594792
32Ether lipid metabolism_Homo sapiens_hsa005651.59702417
33Fatty acid biosynthesis_Homo sapiens_hsa000611.55833681
34Fatty acid degradation_Homo sapiens_hsa000711.45181915
35Pancreatic secretion_Homo sapiens_hsa049721.44301584
36Propanoate metabolism_Homo sapiens_hsa006401.42638309
37Glycerolipid metabolism_Homo sapiens_hsa005611.39994671
38Basal transcription factors_Homo sapiens_hsa030221.39196447
39Protein export_Homo sapiens_hsa030601.27876601
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26366465
41Olfactory transduction_Homo sapiens_hsa047401.23238089
42Thyroid hormone synthesis_Homo sapiens_hsa049181.22223275
43RNA polymerase_Homo sapiens_hsa030201.17923944
44Dorso-ventral axis formation_Homo sapiens_hsa043201.17851776
45Retinol metabolism_Homo sapiens_hsa008301.15907779
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14202103
47Homologous recombination_Homo sapiens_hsa034401.13477657
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11531683
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10439877
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.08618761
51Taste transduction_Homo sapiens_hsa047421.03217110
52Carbon metabolism_Homo sapiens_hsa012001.02987152
53Morphine addiction_Homo sapiens_hsa050321.02920948
54PPAR signaling pathway_Homo sapiens_hsa033201.01243585
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.99356985
56Fatty acid metabolism_Homo sapiens_hsa012120.97915109
57RNA degradation_Homo sapiens_hsa030180.95897351
58Bile secretion_Homo sapiens_hsa049760.94330520
59Peroxisome_Homo sapiens_hsa041460.94069834
60Fanconi anemia pathway_Homo sapiens_hsa034600.93747701
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92604309
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92559436
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.92507570
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91700582
65Nicotine addiction_Homo sapiens_hsa050330.91647797
66Serotonergic synapse_Homo sapiens_hsa047260.89894390
67Parkinsons disease_Homo sapiens_hsa050120.88890727
68Pentose phosphate pathway_Homo sapiens_hsa000300.86971545
69Tight junction_Homo sapiens_hsa045300.85226622
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84727995
71Circadian entrainment_Homo sapiens_hsa047130.82223332
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81952271
73Selenocompound metabolism_Homo sapiens_hsa004500.79540424
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77636250
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76989628
76Regulation of autophagy_Homo sapiens_hsa041400.76739753
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74093332
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73357493
79Fructose and mannose metabolism_Homo sapiens_hsa000510.71969071
80Glucagon signaling pathway_Homo sapiens_hsa049220.71892185
81T cell receptor signaling pathway_Homo sapiens_hsa046600.69217137
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69211135
83Arachidonic acid metabolism_Homo sapiens_hsa005900.65689582
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63087873
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61712337
86Ovarian steroidogenesis_Homo sapiens_hsa049130.61215874
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60782921
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.59907651
89Hematopoietic cell lineage_Homo sapiens_hsa046400.59288610
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58880532
91Thyroid cancer_Homo sapiens_hsa052160.57189663
92Nitrogen metabolism_Homo sapiens_hsa009100.54597393
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53374962
94Rheumatoid arthritis_Homo sapiens_hsa053230.52842381
95GABAergic synapse_Homo sapiens_hsa047270.52121208
96Sulfur relay system_Homo sapiens_hsa041220.50653692
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49844824
98Salivary secretion_Homo sapiens_hsa049700.49616385
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.47817018
100Long-term depression_Homo sapiens_hsa047300.47736260
101Histidine metabolism_Homo sapiens_hsa003400.47272415
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47252612
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47038558
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.46587402
105Alzheimers disease_Homo sapiens_hsa050100.46563778
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45358707
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45269816
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45269561
109Biosynthesis of amino acids_Homo sapiens_hsa012300.44518516
110Calcium signaling pathway_Homo sapiens_hsa040200.43173633
111Adherens junction_Homo sapiens_hsa045200.43020453
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42890365
113Estrogen signaling pathway_Homo sapiens_hsa049150.41650580
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41390607
115Renin secretion_Homo sapiens_hsa049240.38752217
116Oocyte meiosis_Homo sapiens_hsa041140.37564708
117Purine metabolism_Homo sapiens_hsa002300.37470439
118Circadian rhythm_Homo sapiens_hsa047100.36278607
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34832069
120Phenylalanine metabolism_Homo sapiens_hsa003600.34755051
121Glutamatergic synapse_Homo sapiens_hsa047240.34247312
122Huntingtons disease_Homo sapiens_hsa050160.34072638
123Cardiac muscle contraction_Homo sapiens_hsa042600.33083755
124One carbon pool by folate_Homo sapiens_hsa006700.32754767
125Staphylococcus aureus infection_Homo sapiens_hsa051500.32063269
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.29564319
127ECM-receptor interaction_Homo sapiens_hsa045120.28719321
128Oxidative phosphorylation_Homo sapiens_hsa001900.28411755
129African trypanosomiasis_Homo sapiens_hsa051430.26756196
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.25553735
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.25490299
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25357042
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24992622
134ABC transporters_Homo sapiens_hsa020100.24831939
135Salmonella infection_Homo sapiens_hsa051320.24306075
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22025812
137Toxoplasmosis_Homo sapiens_hsa051450.21713735
138VEGF signaling pathway_Homo sapiens_hsa043700.21196184
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.19460862
140Insulin secretion_Homo sapiens_hsa049110.18587062
141beta-Alanine metabolism_Homo sapiens_hsa004100.18201976
142Focal adhesion_Homo sapiens_hsa045100.17476159
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15922528
144Long-term potentiation_Homo sapiens_hsa047200.15463454
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14173482
146Endocytosis_Homo sapiens_hsa041440.13553186
147Inositol phosphate metabolism_Homo sapiens_hsa005620.13416469
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12684588
149Metabolic pathways_Homo sapiens_hsa011000.11887594
150Protein digestion and absorption_Homo sapiens_hsa049740.10224417
151Butanoate metabolism_Homo sapiens_hsa006500.09354862
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.09308916
153Small cell lung cancer_Homo sapiens_hsa052220.09005788
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08485068
155cAMP signaling pathway_Homo sapiens_hsa040240.08183134
156AMPK signaling pathway_Homo sapiens_hsa041520.07299561
157Bladder cancer_Homo sapiens_hsa052190.06696213
158Antigen processing and presentation_Homo sapiens_hsa046120.06533955
159Proteoglycans in cancer_Homo sapiens_hsa052050.05730611

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