VPS54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)5.67707158
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.54467961
3low-density lipoprotein particle remodeling (GO:0034374)5.20551928
4negative regulation of protein activation cascade (GO:2000258)5.17304847
5plasma lipoprotein particle assembly (GO:0034377)5.09622890
6regulation of protein activation cascade (GO:2000257)4.92031182
7regulation of complement activation (GO:0030449)4.88355949
8negative regulation of complement activation (GO:0045916)4.69693690
9positive regulation of gamma-delta T cell activation (GO:0046645)4.68685948
10negative regulation of fibrinolysis (GO:0051918)4.67249510
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44981512
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44981512
13protein-lipid complex assembly (GO:0065005)4.37821827
14protein-lipid complex remodeling (GO:0034368)4.26979984
15macromolecular complex remodeling (GO:0034367)4.26979984
16plasma lipoprotein particle remodeling (GO:0034369)4.26979984
17intestinal cholesterol absorption (GO:0030299)4.25819301
18cholesterol efflux (GO:0033344)4.20052227
19COPII vesicle coating (GO:0048208)4.14916598
20plasma lipoprotein particle organization (GO:0071827)4.06315273
21high-density lipoprotein particle remodeling (GO:0034375)4.06249970
22regulation of fibrinolysis (GO:0051917)4.06018566
23antigen processing and presentation of endogenous antigen (GO:0019883)3.85648273
24definitive hemopoiesis (GO:0060216)3.84051201
25reverse cholesterol transport (GO:0043691)3.80500706
26protein-lipid complex subunit organization (GO:0071825)3.73412125
27regulation of establishment of cell polarity (GO:2000114)3.65073485
28intestinal absorption (GO:0050892)3.63859073
29regulation of gamma-delta T cell activation (GO:0046643)3.62552981
30embryonic retina morphogenesis in camera-type eye (GO:0060059)3.62379775
31monoubiquitinated protein deubiquitination (GO:0035520)3.61550395
32regulation of apoptotic cell clearance (GO:2000425)3.60544221
33negative regulation of humoral immune response (GO:0002921)3.59673508
34regulation of gamma-delta T cell differentiation (GO:0045586)3.57293862
35regulation of cholesterol esterification (GO:0010872)3.55965988
36cellular response to ethanol (GO:0071361)3.47487028
37regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.36230216
38interkinetic nuclear migration (GO:0022027)3.32751918
39positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.27013542
40nerve growth factor signaling pathway (GO:0038180)3.24330908
41regulation of interferon-alpha production (GO:0032647)3.23764546
42peptidyl-glutamic acid carboxylation (GO:0017187)3.23490967
43protein carboxylation (GO:0018214)3.23490967
44plasma lipoprotein particle clearance (GO:0034381)3.21986116
45blood coagulation, intrinsic pathway (GO:0007597)3.21914107
46antigen processing and presentation via MHC class Ib (GO:0002475)3.21538943
47regulation of non-canonical Wnt signaling pathway (GO:2000050)3.21071964
48regulation of bile acid biosynthetic process (GO:0070857)3.18583978
49complement activation, alternative pathway (GO:0006957)3.13880902
50lipoprotein metabolic process (GO:0042157)3.13227011
51positive regulation of interferon-alpha production (GO:0032727)3.12744402
52positive regulation of B cell differentiation (GO:0045579)3.11577195
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.06284475
54hepatocyte apoptotic process (GO:0097284)3.05493436
55positive regulation of natural killer cell differentiation (GO:0032825)3.04547335
56lipid translocation (GO:0034204)3.03952764
57phospholipid translocation (GO:0045332)3.03952764
58response to interferon-alpha (GO:0035455)3.03498321
59Golgi to endosome transport (GO:0006895)3.01048735
60sterol transport (GO:0015918)2.97914412
61cholesterol transport (GO:0030301)2.97914412
62regulation of establishment or maintenance of cell polarity (GO:0032878)2.96732647
63carnitine transport (GO:0015879)2.96708235
64amino-acid betaine transport (GO:0015838)2.96708235
65positive regulation of hemostasis (GO:1900048)2.94857287
66positive regulation of blood coagulation (GO:0030194)2.94857287
67negative regulation of sterol transport (GO:0032372)2.93577226
68negative regulation of cholesterol transport (GO:0032375)2.93577226
69glycoprotein catabolic process (GO:0006516)2.93431742
70regulation of interleukin-12 biosynthetic process (GO:0045075)2.92592906
71negative regulation of norepinephrine secretion (GO:0010700)2.91558711
72response to nitrosative stress (GO:0051409)2.91243402
73response to type I interferon (GO:0034340)2.88954001
74regulation of protein polyubiquitination (GO:1902914)2.87226396
75regulation of sarcomere organization (GO:0060297)2.86065959
76positive regulation of coagulation (GO:0050820)2.82999536
77regulation of glucokinase activity (GO:0033131)2.82517391
78regulation of hexokinase activity (GO:1903299)2.82517391
79type I interferon signaling pathway (GO:0060337)2.81508013
80cellular response to type I interferon (GO:0071357)2.81508013
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.79949253
82regulation of B cell receptor signaling pathway (GO:0050855)2.76891454
83valine metabolic process (GO:0006573)2.75970307
84regulation of RIG-I signaling pathway (GO:0039535)2.75828931
85phospholipid efflux (GO:0033700)2.75312855
86nephron epithelium morphogenesis (GO:0072088)2.74458473
87nephron tubule morphogenesis (GO:0072078)2.74458473
88nuclear pore complex assembly (GO:0051292)2.72310357
89dicarboxylic acid biosynthetic process (GO:0043650)2.71653435
90L-ascorbic acid metabolic process (GO:0019852)2.71117356
91regulation of B cell differentiation (GO:0045577)2.69762836
92lipoprotein transport (GO:0042953)2.69624831
93negative regulation of B cell proliferation (GO:0030889)2.68930885
94immunoglobulin mediated immune response (GO:0016064)2.66769750
95negative regulation of sodium ion transport (GO:0010766)2.66128681
96carnitine transmembrane transport (GO:1902603)2.63511123
97phospholipid homeostasis (GO:0055091)2.62015122
98mRNA modification (GO:0016556)2.61347719
99pinocytosis (GO:0006907)2.60607390
100drug transmembrane transport (GO:0006855)2.60189302
101positive regulation by symbiont of host defense response (GO:0052509)2.59238336
102modulation by symbiont of host defense response (GO:0052031)2.59238336
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.59238336
104modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.59238336
105positive regulation by organism of defense response of other organism involved in symbiotic interact2.59238336
106modulation by symbiont of host immune response (GO:0052553)2.59238336
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58570479
108tolerance induction (GO:0002507)2.57749827
109regulation of alpha-beta T cell proliferation (GO:0046640)2.57289051
110negative regulation of interleukin-12 production (GO:0032695)2.56861700
111renal tubule morphogenesis (GO:0061333)2.55834651
112photoreceptor cell differentiation (GO:0046530)2.55817515
113eye photoreceptor cell differentiation (GO:0001754)2.55817515
114positive regulation of glycolytic process (GO:0045821)2.55335376
115regulation of regulatory T cell differentiation (GO:0045589)2.55040352
116negative regulation of granulocyte differentiation (GO:0030853)2.54687635
117phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.54480424
118regulation of interferon-beta biosynthetic process (GO:0045357)2.54432260
119positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.54384350
120regulation of humoral immune response (GO:0002920)2.53092127
121regulation of natural killer cell differentiation (GO:0032823)2.52875305
122positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52873831
123leukocyte aggregation (GO:0070486)2.52840426
124interferon-gamma production (GO:0032609)2.51329623
125establishment of protein localization to Golgi (GO:0072600)2.50732448
126response to protozoan (GO:0001562)2.50541540
127negative regulation of DNA repair (GO:0045738)2.49459558
128mature B cell differentiation (GO:0002335)2.48988405
129defense response to protozoan (GO:0042832)2.48727584
130embryonic process involved in female pregnancy (GO:0060136)2.48222214
131regulation of cholesterol homeostasis (GO:2000188)2.48059667
132B cell mediated immunity (GO:0019724)2.47604228
133myeloid dendritic cell activation (GO:0001773)2.47221026
134positive regulation of interferon-beta production (GO:0032728)2.46590953
135UDP-N-acetylglucosamine metabolic process (GO:0006047)2.46473357
136negative T cell selection (GO:0043383)2.46160020
137histone H3-K9 demethylation (GO:0033169)2.43573718
138JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.43564412
139regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.41705827
140triglyceride homeostasis (GO:0070328)2.41649433
141acylglycerol homeostasis (GO:0055090)2.41649433
142negative thymic T cell selection (GO:0045060)2.40872337
143response to interleukin-15 (GO:0070672)2.40825798
144positive regulation of hormone biosynthetic process (GO:0046886)2.40536325
145T cell migration (GO:0072678)2.40208696
146regulation of T cell receptor signaling pathway (GO:0050856)2.39901258
147quaternary ammonium group transport (GO:0015697)2.39549344
148glutamate metabolic process (GO:0006536)2.39309285
149negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38706152
150negative regulation of cell killing (GO:0031342)2.38706152
151negative regulation of erythrocyte differentiation (GO:0045647)2.38050498
152T-helper cell differentiation (GO:0042093)2.37797436
153CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.37797436
154regulation of response to interferon-gamma (GO:0060330)2.37509455
155sterol homeostasis (GO:0055092)2.36427945
156regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.35841756
157mitotic sister chromatid cohesion (GO:0007064)2.35570133
158regulation of plasminogen activation (GO:0010755)2.35211159
159megakaryocyte development (GO:0035855)2.35116810
160bundle of His cell to Purkinje myocyte communication (GO:0086069)2.34977026
161cysteine metabolic process (GO:0006534)2.33222946
162protein activation cascade (GO:0072376)2.32474495
163positive regulation of humoral immune response (GO:0002922)2.32437112
164positive regulation of T cell mediated cytotoxicity (GO:0001916)2.32060767
165cholesterol homeostasis (GO:0042632)2.31883957
166alpha-beta T cell activation (GO:0046631)2.31642695
167ectodermal placode formation (GO:0060788)2.30928020
168mature B cell differentiation involved in immune response (GO:0002313)2.30407214
169CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.29488707
170detection of bacterium (GO:0016045)2.29379796
171nuclear pore organization (GO:0006999)2.29249401
172regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.29248130
173cellular response to zinc ion (GO:0071294)2.28950463
174detection of other organism (GO:0098543)2.28946619
175response to muramyl dipeptide (GO:0032495)2.28537215
176interferon-gamma-mediated signaling pathway (GO:0060333)2.26619212
177positive regulation of alpha-beta T cell proliferation (GO:0046641)2.26066726
178histone mRNA catabolic process (GO:0071044)2.25473312
179positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.25347424
180negative regulation of viral genome replication (GO:0045071)2.25013953
181pore complex assembly (GO:0046931)2.22884585
182lymph node development (GO:0048535)2.22874855
183regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.22220099
184germinal center formation (GO:0002467)2.21057375
185negative regulation of T-helper cell differentiation (GO:0045623)2.20991557
186negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.20991557
187regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.19176926
188cytokine secretion (GO:0050663)2.19063147
189histone H3-K36 demethylation (GO:0070544)2.18555998
190regulation of interferon-beta production (GO:0032648)2.17845263
191neutrophil activation involved in immune response (GO:0002283)2.15875173
192regulation of natural killer cell activation (GO:0032814)2.15181018
193response to peptidoglycan (GO:0032494)2.14639387
194alpha-beta T cell differentiation (GO:0046632)2.14537252
195T cell homeostasis (GO:0043029)2.13442583
196regulation of type I interferon-mediated signaling pathway (GO:0060338)2.12330985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.04873992
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.97871249
3* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.93083854
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.77751609
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51261577
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25585041
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.03424289
8GATA1_22025678_ChIP-Seq_K562_Human3.02861785
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.98942496
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.98655100
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86568058
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74635012
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.57734600
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55926000
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54378104
16SCL_19346495_ChIP-Seq_HPC-7_Human2.49053585
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.48121938
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.48070027
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47396032
20RUNX_20019798_ChIP-Seq_JUKART_Human2.45391316
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44635854
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43167252
23EGR1_23403033_ChIP-Seq_LIVER_Mouse2.39152049
24GBX2_23144817_ChIP-Seq_PC3_Human2.30083466
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29917405
26* PIAS1_25552417_ChIP-Seq_VCAP_Human2.24505957
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22931298
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22216994
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20774063
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.18122056
31MYB_26560356_Chip-Seq_TH2_Human2.14111799
32IGF1R_20145208_ChIP-Seq_DFB_Human2.13409210
33* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10923458
34ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10461444
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.09044771
36TAF15_26573619_Chip-Seq_HEK293_Human2.03188462
37* FOXA2_19822575_ChIP-Seq_HepG2_Human2.02170800
38MYB_26560356_Chip-Seq_TH1_Human2.01376259
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99535899
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.98930964
41FUS_26573619_Chip-Seq_HEK293_Human1.96380442
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94113826
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93521427
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.93310266
45MYC_22102868_ChIP-Seq_BL_Human1.92844965
46VDR_22108803_ChIP-Seq_LS180_Human1.91698212
47* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89817304
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86943801
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.85513037
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84930168
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84031665
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.81990144
53ZNF274_21170338_ChIP-Seq_K562_Hela1.77446983
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76452756
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76452756
56MAF_26560356_Chip-Seq_TH1_Human1.75149887
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.72335470
58* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.71202168
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71085928
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70636011
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70191636
62* STAT3_23295773_ChIP-Seq_U87_Human1.66568149
63* SPI1_23547873_ChIP-Seq_NB4_Human1.66400549
64ER_23166858_ChIP-Seq_MCF-7_Human1.65618017
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.64936162
66P300_19829295_ChIP-Seq_ESCs_Human1.64677858
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64455509
68* PU_27001747_Chip-Seq_BMDM_Mouse1.63387879
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62579249
70* SMAD4_21799915_ChIP-Seq_A2780_Human1.62031349
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61466080
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61331936
73TP53_16413492_ChIP-PET_HCT116_Human1.56930368
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.52615327
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52129944
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50595801
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49999578
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49651891
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49394843
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49261884
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49122275
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48792657
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.47226997
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.45017543
85AHR_22903824_ChIP-Seq_MCF-7_Human1.42936319
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.42881367
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42666449
88* TCF4_23295773_ChIP-Seq_U87_Human1.41505113
89* CDX2_22108803_ChIP-Seq_LS180_Human1.41331932
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41170026
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40839706
92EWS_26573619_Chip-Seq_HEK293_Human1.38701898
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.38223070
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37488967
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.36799439
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.36485002
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.36136425
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35804838
99TCF7_22412390_ChIP-Seq_EML_Mouse1.34184739
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.33779323
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33393886
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.32283181
103BCAT_22108803_ChIP-Seq_LS180_Human1.30528388
104UTX_26944678_Chip-Seq_JUKART_Human1.29319782
105VDR_24763502_ChIP-Seq_THP-1_Human1.28828005
106AR_21572438_ChIP-Seq_LNCaP_Human1.28402981
107* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28100989
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28061955
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27352006
110CJUN_26792858_Chip-Seq_BT549_Human1.26163671
111GATA3_27048872_Chip-Seq_THYMUS_Human1.26025424
112ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25564190
113AR_25329375_ChIP-Seq_VCAP_Human1.25352270
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25115684
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24413649
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.23823664
117* FLI1_21867929_ChIP-Seq_TH2_Mouse1.22913883
118TCF4_22108803_ChIP-Seq_LS180_Human1.21913598
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21334195
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20350079
121* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20274895
122FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19819310
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.19677925
124RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19502409
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.19374885
126* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19146164
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.16601899
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15244443
129BRD4_25478319_ChIP-Seq_HGPS_Human1.14704990
130* CRX_20693478_ChIP-Seq_RETINA_Mouse1.14517913
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14445439
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13132175
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12598042
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12567359
135* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11996707
136OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11890267
137CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11671500
138TP63_23658742_ChIP-Seq_EP156T_Human1.11618249
139ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11452096
140TP63_17297297_ChIP-ChIP_HaCaT_Human1.10556692
141VDR_21846776_ChIP-Seq_THP-1_Human1.10228097
142* GATA2_21666600_ChIP-Seq_HMVEC_Human1.09910475
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09828674
144P53_22387025_ChIP-Seq_ESCs_Mouse1.09657862
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07056430
146* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06649500
147* SPI1_23127762_ChIP-Seq_K562_Human1.06026031
148ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05947238
149RXR_22108803_ChIP-Seq_LS180_Human1.05898213
150CBP_20019798_ChIP-Seq_JUKART_Human1.05264854
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05264854
152* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04022362
153E2F1_21310950_ChIP-Seq_MCF-7_Human1.02924056
154CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01648885
155FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01443325
156SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99212854
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99212854
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97369977
159* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93615732
160SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92275334
161KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91016542
162VDR_24787735_ChIP-Seq_THP-1_Human0.91011233
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90783055
164* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90716153
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90178425
166GATA3_26560356_Chip-Seq_TH2_Human0.90138900
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89534205
168LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89304661
169* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88217432
170ELK1_19687146_ChIP-ChIP_HELA_Human0.88045906
171CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87779680
172TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85384133
173CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85335017
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85266286
175NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84056321
176GATA4_25053715_ChIP-Seq_YYC3_Human0.81104238
177HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80914251
178GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80062156
179FOXO3_23340844_ChIP-Seq_DLD1_Human0.79307623
180CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79050137
181FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78420375
182* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77111858
183KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76209429
184CDX2_20551321_ChIP-Seq_CACO-2_Human0.75784970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.71264693
2MP0001835_abnormal_antigen_presentation3.10364305
3MP0003122_maternal_imprinting3.00144399
4MP0003890_abnormal_embryonic-extraembry2.95518493
5MP0003950_abnormal_plasma_membrane2.94891019
6MP0008057_abnormal_DNA_replication2.94626917
7MP0005671_abnormal_response_to2.58213852
8MP0002166_altered_tumor_susceptibility2.46627189
9MP0009785_altered_susceptibility_to2.45356666
10MP0002396_abnormal_hematopoietic_system2.31284430
11MP0003763_abnormal_thymus_physiology2.29426040
12MP0003300_gastrointestinal_ulcer2.27305386
13MP0000685_abnormal_immune_system2.26055692
14MP0002139_abnormal_hepatobiliary_system2.23863413
15MP0010678_abnormal_skin_adnexa2.19521728
16MP0003436_decreased_susceptibility_to2.18972963
17MP0001800_abnormal_humoral_immune2.18179374
18MP0003303_peritoneal_inflammation2.11874204
19MP0003183_abnormal_peptide_metabolism2.07179541
20MP0003724_increased_susceptibility_to2.06805248
21MP0001873_stomach_inflammation2.03191500
22MP0005365_abnormal_bile_salt2.00502778
23MP0005025_abnormal_response_to2.00349036
24MP0010155_abnormal_intestine_physiology1.99643644
25MP0002006_tumorigenesis1.99018094
26MP0000383_abnormal_hair_follicle1.96807576
27MP0005408_hypopigmentation1.94934283
28MP0002452_abnormal_antigen_presenting1.90697042
29MP0005387_immune_system_phenotype1.85665403
30MP0001790_abnormal_immune_system1.85665403
31MP0000569_abnormal_digit_pigmentation1.85042700
32MP0005000_abnormal_immune_tolerance1.84668202
33MP0002723_abnormal_immune_serum1.83276611
34MP0005360_urolithiasis1.81818849
35MP0001853_heart_inflammation1.79565942
36MP0001819_abnormal_immune_cell1.76140060
37MP0002420_abnormal_adaptive_immunity1.75683441
38MP0010352_gastrointestinal_tract_polyps1.73418679
39MP0002419_abnormal_innate_immunity1.71204261
40MP0005464_abnormal_platelet_physiology1.70587249
41MP0000490_abnormal_crypts_of1.69143804
42MP0005084_abnormal_gallbladder_morpholo1.65725863
43MP0003656_abnormal_erythrocyte_physiolo1.65381376
44MP0003136_yellow_coat_color1.65330799
45MP0002398_abnormal_bone_marrow1.64755725
46MP0005085_abnormal_gallbladder_physiolo1.57629207
47MP0001915_intracranial_hemorrhage1.57216789
48MP0003252_abnormal_bile_duct1.56537117
49MP0010234_abnormal_vibrissa_follicle1.56312009
50MP0004264_abnormal_extraembryonic_tissu1.55370742
51MP0002148_abnormal_hypersensitivity_rea1.55309571
52MP0004808_abnormal_hematopoietic_stem1.54373931
53MP0004947_skin_inflammation1.51967264
54MP0000716_abnormal_immune_system1.51829218
55MP0000465_gastrointestinal_hemorrhage1.51757584
56MP0002009_preneoplasia1.48002983
57MP0001845_abnormal_inflammatory_respons1.44795135
58MP0003868_abnormal_feces_composition1.44156604
59MP0005174_abnormal_tail_pigmentation1.41197000
60MP0000689_abnormal_spleen_morphology1.40041715
61MP0006082_CNS_inflammation1.38642531
62MP0009333_abnormal_splenocyte_physiolog1.36640416
63MP0005397_hematopoietic_system_phenotyp1.35791607
64MP0001545_abnormal_hematopoietic_system1.35791607
65MP0002722_abnormal_immune_system1.33250051
66MP0005075_abnormal_melanosome_morpholog1.32913837
67MP0003866_abnormal_defecation1.30865498
68MP0001324_abnormal_eye_pigmentation1.28744742
69MP0002405_respiratory_system_inflammati1.27718842
70MP0002429_abnormal_blood_cell1.26905157
71MP0008469_abnormal_protein_level1.25734502
72MP0003121_genomic_imprinting1.24564456
73MP0002138_abnormal_hepatobiliary_system1.18945920
74MP0000371_diluted_coat_color1.17938252
75MP0003191_abnormal_cellular_cholesterol1.14932447
76MP0009764_decreased_sensitivity_to1.13670319
77MP0004272_abnormal_basement_membrane1.12553990
78MP0002118_abnormal_lipid_homeostasis1.11619214
79MP0001666_abnormal_nutrient_absorption1.10449932
80MP0000703_abnormal_thymus_morphology1.09831974
81MP0002089_abnormal_postnatal_growth/wei1.08194709
82MP0000609_abnormal_liver_physiology1.06270987
83MP0002971_abnormal_brown_adipose1.04043688
84MP0001533_abnormal_skeleton_physiology1.03464198
85MP0002086_abnormal_extraembryonic_tissu1.03439162
86MP0008875_abnormal_xenobiotic_pharmacok1.03264517
87MP0010329_abnormal_lipoprotein_level1.02783904
88MP0010307_abnormal_tumor_latency1.02500076
89MP0004134_abnormal_chest_morphology0.98935572
90MP0005332_abnormal_amino_acid0.98542900
91MP0009763_increased_sensitivity_to0.97536805
92MP0000015_abnormal_ear_pigmentation0.96822016
93MP0005379_endocrine/exocrine_gland_phen0.96746275
94MP0002088_abnormal_embryonic_growth/wei0.96256615
95MP0009278_abnormal_bone_marrow0.94673624
96MP0002168_other_aberrant_phenotype0.93704694
97MP0009780_abnormal_chondrocyte_physiolo0.93595589
98MP0002933_joint_inflammation0.93579007
99MP0006054_spinal_hemorrhage0.93471013
100MP0002095_abnormal_skin_pigmentation0.93333659
101MP0005076_abnormal_cell_differentiation0.93244559
102MP0000427_abnormal_hair_cycle0.92074102
103MP0002876_abnormal_thyroid_physiology0.92048931
104MP0003984_embryonic_growth_retardation0.91958668
105MP0000639_abnormal_adrenal_gland0.91023663
106MP0005410_abnormal_fertilization0.90709496
107MP0009697_abnormal_copulation0.89727933
108MP0002102_abnormal_ear_morphology0.89421960
109MP0009115_abnormal_fat_cell0.89396088
110MP0003943_abnormal_hepatobiliary_system0.88913599
111MP0000477_abnormal_intestine_morphology0.88069952
112MP0005187_abnormal_penis_morphology0.87875406
113MP0005164_abnormal_response_to0.86554420
114MP0002019_abnormal_tumor_incidence0.85884367
115MP0005551_abnormal_eye_electrophysiolog0.85198824
116MP0003448_altered_tumor_morphology0.84971410
117MP0002160_abnormal_reproductive_system0.84383682
118MP0005409_darkened_coat_color0.84150752
119MP0002909_abnormal_adrenal_gland0.82646097
120MP0004782_abnormal_surfactant_physiolog0.81937161
121MP0002998_abnormal_bone_remodeling0.81804127
122MP0002938_white_spotting0.81539688
123MP0005220_abnormal_exocrine_pancreas0.81285101
124MP0000372_irregular_coat_pigmentation0.80733221
125MP0005023_abnormal_wound_healing0.80267424
126MP0001270_distended_abdomen0.79862390
127MP0010094_abnormal_chromosome_stability0.79767161
128MP0005319_abnormal_enzyme/_coenzyme0.79754016
129* MP0000598_abnormal_liver_morphology0.79526834
130MP0003566_abnormal_cell_adhesion0.79202846
131MP0000858_altered_metastatic_potential0.78641148
132MP0001756_abnormal_urination0.78495270
133MP0001286_abnormal_eye_development0.78052808
134MP0003937_abnormal_limbs/digits/tail_de0.77685989
135MP0009765_abnormal_xenobiotic_induced0.76671514
136MP0003567_abnormal_fetal_cardiomyocyte0.76653455
137MP0003011_delayed_dark_adaptation0.75872332
138MP0005380_embryogenesis_phenotype0.75034717
139MP0001672_abnormal_embryogenesis/_devel0.75034717
140MP0002084_abnormal_developmental_patter0.74625717
141MP0003935_abnormal_craniofacial_develop0.74390379
142MP0001661_extended_life_span0.74328798
143MP0002128_abnormal_blood_circulation0.73589801
144MP0002132_abnormal_respiratory_system0.73392996
145MP0002896_abnormal_bone_mineralization0.72636586
146MP0008007_abnormal_cellular_replicative0.72000092
147MP0000013_abnormal_adipose_tissue0.71800854
148MP0003045_fibrosis0.71105114
149MP0000534_abnormal_ureter_morphology0.71017002
150MP0002282_abnormal_trachea_morphology0.70618687
151MP0003453_abnormal_keratinocyte_physiol0.69631388
152MP0002925_abnormal_cardiovascular_devel0.69617967
153* MP0003632_abnormal_nervous_system0.69138134
154MP0002136_abnormal_kidney_physiology0.69128254
155MP0005310_abnormal_salivary_gland0.68687702
156MP0010368_abnormal_lymphatic_system0.68297459
157MP0003828_pulmonary_edema0.68259470
158MP0005636_abnormal_mineral_homeostasis0.67711240
159MP0001879_abnormal_lymphatic_vessel0.67558373
160MP0002928_abnormal_bile_duct0.67484378
161MP0002233_abnormal_nose_morphology0.66442447
162MP0005083_abnormal_biliary_tract0.65441052
163MP0004019_abnormal_vitamin_homeostasis0.65311184
164MP0002877_abnormal_melanocyte_morpholog0.65110531
165MP0005248_abnormal_Harderian_gland0.64742586
166MP0001697_abnormal_embryo_size0.64372857
167MP0004883_abnormal_blood_vessel0.63935494
168MP0009384_cardiac_valve_regurgitation0.63785694
169MP0003123_paternal_imprinting0.63557232

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.75527992
2Hypobetalipoproteinemia (HP:0003563)4.80551340
3Papillary thyroid carcinoma (HP:0002895)4.30549194
4Acanthocytosis (HP:0001927)4.16967316
5Complement deficiency (HP:0004431)3.58737028
6Epidermoid cyst (HP:0200040)3.53540001
7Eczematoid dermatitis (HP:0000976)3.34913951
8Abnormality of the fingertips (HP:0001211)3.32570819
9Myositis (HP:0100614)3.28763090
10Abnormality of the nasal septum (HP:0000419)3.27605829
11Conjugated hyperbilirubinemia (HP:0002908)3.23427222
12Recurrent fungal infections (HP:0002841)3.23208443
13Pancreatic islet-cell hyperplasia (HP:0004510)3.21287225
14Recurrent viral infections (HP:0004429)3.16660107
15Enlarged kidneys (HP:0000105)3.12064672
16Spontaneous abortion (HP:0005268)3.11930021
17Reduced antithrombin III activity (HP:0001976)3.06537892
18Vascular calcification (HP:0004934)3.05445192
19Abnormality of the lumbar spine (HP:0100712)3.04129322
20Optic neuritis (HP:0100653)3.03859886
21Retrobulbar optic neuritis (HP:0100654)3.03859886
22IgM deficiency (HP:0002850)3.01939174
23Recurrent gram-negative bacterial infections (HP:0005420)2.94661060
24Flat acetabular roof (HP:0003180)2.94136027
25Arterial thrombosis (HP:0004420)2.91659601
26Autoimmune thrombocytopenia (HP:0001973)2.89389132
27Hypolipoproteinemia (HP:0010981)2.89086566
28Periodontitis (HP:0000704)2.87613625
29Abnormality of the prostate (HP:0008775)2.86925598
30Orchitis (HP:0100796)2.86666333
31Cardiovascular calcification (HP:0011915)2.84357301
32Gingival bleeding (HP:0000225)2.83022367
33Elevated erythrocyte sedimentation rate (HP:0003565)2.81578413
34Broad palm (HP:0001169)2.78717014
35Recurrent abscess formation (HP:0002722)2.77687813
36Glomerulonephritis (HP:0000099)2.76404985
37Thyroid carcinoma (HP:0002890)2.74830649
38Broad alveolar ridges (HP:0000187)2.74396076
39Acute myeloid leukemia (HP:0004808)2.72235230
40Vasculitis (HP:0002633)2.72213555
41Thrombocytosis (HP:0001894)2.69350458
42Mediastinal lymphadenopathy (HP:0100721)2.66581795
43Xanthomatosis (HP:0000991)2.65987108
44Hematochezia (HP:0002573)2.65902550
45Meningitis (HP:0001287)2.65558892
46Chronic diarrhea (HP:0002028)2.65024598
47T lymphocytopenia (HP:0005403)2.64747782
48Recurrent bacterial skin infections (HP:0005406)2.62152956
49Recurrent bronchitis (HP:0002837)2.61285244
50B lymphocytopenia (HP:0010976)2.61087706
51Abnormality of B cell number (HP:0010975)2.61087706
52Abnormality of T cell number (HP:0011839)2.58821239
53Hypoplasia of the thymus (HP:0000778)2.57396647
54Abnormality of carpal bone ossification (HP:0006257)2.55808438
55Epistaxis (HP:0000421)2.50867145
56Fat malabsorption (HP:0002630)2.50635053
57Abnormality of the intrinsic pathway (HP:0010989)2.50318025
58Scanning speech (HP:0002168)2.49008101
59Abnormality of T cells (HP:0002843)2.48906599
60Stomatitis (HP:0010280)2.47982475
61Hemoptysis (HP:0002105)2.46559718
62Abnormality of the wing of the ilium (HP:0011867)2.43770247
63Prolonged bleeding time (HP:0003010)2.43573770
64Abnormality of T cell physiology (HP:0011840)2.43086306
65Severe combined immunodeficiency (HP:0004430)2.43047102
66Proximal tubulopathy (HP:0000114)2.42616698
67Embryonal renal neoplasm (HP:0011794)2.41644823
68Gastrointestinal infarctions (HP:0005244)2.40759076
69Joint hemorrhage (HP:0005261)2.40095205
70Prolonged partial thromboplastin time (HP:0003645)2.37361610
71Hypochromic microcytic anemia (HP:0004840)2.37109535
72Encephalitis (HP:0002383)2.36778962
73Chronic otitis media (HP:0000389)2.33273160
74Abnormal tarsal ossification (HP:0008369)2.33084715
75IgA deficiency (HP:0002720)2.32029861
76Amaurosis fugax (HP:0100576)2.31663244
77Abnormality of complement system (HP:0005339)2.31472392
78Pustule (HP:0200039)2.30492841
79Mitral stenosis (HP:0001718)2.29078269
80Keratoconjunctivitis sicca (HP:0001097)2.28398167
81Abnormal platelet volume (HP:0011876)2.28168292
82Recurrent cutaneous fungal infections (HP:0011370)2.26847184
83Chronic mucocutaneous candidiasis (HP:0002728)2.26847184
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26605420
85Hypercholesterolemia (HP:0003124)2.26510680
86Combined immunodeficiency (HP:0005387)2.26226176
87Osteomalacia (HP:0002749)2.25857241
88Volvulus (HP:0002580)2.23102925
89Fair hair (HP:0002286)2.22076383
90Subacute progressive viral hepatitis (HP:0006572)2.21933224
91Asymmetry of the thorax (HP:0001555)2.21066214
92Thyroiditis (HP:0100646)2.20931550
93Submucous cleft hard palate (HP:0000176)2.19388694
94Obstructive lung disease (HP:0006536)2.18358075
95Chronic obstructive pulmonary disease (HP:0006510)2.18358075
96Epiphyseal dysplasia (HP:0002656)2.18303417
97Thrombophlebitis (HP:0004418)2.17444264
98Abnormal hand bone ossification (HP:0010660)2.17059121
99Chest pain (HP:0100749)2.16385859
100Menorrhagia (HP:0000132)2.16198231
101Ureteral stenosis (HP:0000071)2.15534359
102Abnormality of monocarboxylic acid metabolism (HP:0010996)2.14408402
103Skin nodule (HP:0200036)2.13928887
104IgG deficiency (HP:0004315)2.13232923
105Hypothermia (HP:0002045)2.12951114
106Recurrent skin infections (HP:0001581)2.11557220
107Gangrene (HP:0100758)2.10664329
108Ureteral obstruction (HP:0006000)2.09759449
109Spontaneous hematomas (HP:0007420)2.09555519
110Abnormal foot bone ossification (HP:0010675)2.09554011
111Pulmonary infiltrates (HP:0002113)2.09495502
112Panhypogammaglobulinemia (HP:0003139)2.09165428
113Coarse hair (HP:0002208)2.09039616
114Pulmonary embolism (HP:0002204)2.08739469
115Nephroblastoma (Wilms tumor) (HP:0002667)2.07899872
116Keratoconjunctivitis (HP:0001096)2.06986845
117Cheilitis (HP:0100825)2.06795263
118Abnormal delayed hypersensitivity skin test (HP:0002963)2.05507046
119Joint swelling (HP:0001386)2.05367625
120Lymphopenia (HP:0001888)2.04866479
121Diastasis recti (HP:0001540)2.04695484
122Pigmentary retinal degeneration (HP:0001146)2.04082285
123Decreased lacrimation (HP:0000633)2.03824628
124Poikilocytosis (HP:0004447)2.03668702
125Abnormality of the pubic bones (HP:0003172)2.03381680
126Lower limb hyperreflexia (HP:0002395)2.02113438
127Hepatoblastoma (HP:0002884)2.01554459
128Renal cortical cysts (HP:0000803)2.01503329
129Bilateral sensorineural hearing impairment (HP:0008619)2.01464056
130Increased mean platelet volume (HP:0011877)2.01331002
131Portal hypertension (HP:0001409)2.00985441
132Impaired platelet aggregation (HP:0003540)2.00279031
133Abnormal platelet function (HP:0011869)2.00279031
134Alacrima (HP:0000522)1.99722583
135Inflammation of the large intestine (HP:0002037)1.99715722
136Leukocytosis (HP:0001974)1.98801583
137Myocardial infarction (HP:0001658)1.98662587
138Arterial tortuosity (HP:0005116)1.96845680
139Abnormality of cells of the lymphoid lineage (HP:0012140)1.96330711
140Abnormal biliary tract morphology (HP:0012440)1.94944999
141Potter facies (HP:0002009)1.94826259
142Facial shape deformation (HP:0011334)1.94826259
143Intrahepatic cholestasis (HP:0001406)1.94575250
144Type I transferrin isoform profile (HP:0003642)1.94507820
145Autoimmune hemolytic anemia (HP:0001890)1.94157709
146Osteomyelitis (HP:0002754)1.94142953
147Biliary tract neoplasm (HP:0100574)1.93917738
148Right ventricular cardiomyopathy (HP:0011663)1.93908240
149Thickened calvaria (HP:0002684)1.93791938
150Abnormality of the common coagulation pathway (HP:0010990)1.93240305
151Esophageal varix (HP:0002040)1.93057459
152Hydroxyprolinuria (HP:0003080)1.90126155
153Abnormality of proline metabolism (HP:0010907)1.90126155
154Eosinophilia (HP:0001880)1.88951716
155Cellulitis (HP:0100658)1.88404743
156Abnormality of endocrine pancreas physiology (HP:0012093)1.88294923
157Abnormality of the pancreatic islet cells (HP:0006476)1.88294923
158Small epiphyses (HP:0010585)1.88088730
159Microcytic anemia (HP:0001935)1.88078517
160Thoracic kyphosis (HP:0002942)1.87615569
161Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87280778
162Abnormality of eosinophils (HP:0001879)1.87142853
163Anorexia (HP:0002039)1.86675609
164Hypophosphatemic rickets (HP:0004912)1.86613085
165Granulocytopenia (HP:0001913)1.85417014
166Hepatocellular carcinoma (HP:0001402)1.85092021
167Lymphoma (HP:0002665)1.84771849
168Gingivitis (HP:0000230)1.84546159
169Arthropathy (HP:0003040)1.83937770
170Abnormality of the pleura (HP:0002103)1.83383831
171Abnormal ossification of hand bones (HP:0005921)1.83196036
172Hypoglycemic seizures (HP:0002173)1.82740687
173Striae distensae (HP:0001065)1.80863514
174Neoplasm of the liver (HP:0002896)1.79518772
175Overlapping toe (HP:0001845)1.79493634
176Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78010826
177Hypoglycemic coma (HP:0001325)1.77476548
178Heterotopia (HP:0002282)1.77402099
179Abnormality of the hepatic vasculature (HP:0006707)1.76896421
180Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76101325
181Wide nose (HP:0000445)1.75410695
182Midline defect of the nose (HP:0004122)1.75360294
183Blue irides (HP:0000635)1.74979644
184Central scotoma (HP:0000603)1.73392662
185Tapered finger (HP:0001182)1.72973368
186Abnormality of the renal cortex (HP:0011035)1.68851942
187Missing ribs (HP:0000921)1.66284174
188Disproportionate short-trunk short stature (HP:0003521)1.65820144
189Delayed closure of the anterior fontanelle (HP:0001476)1.64964035
190Capillary hemangiomas (HP:0005306)1.64253771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.73587011
2STK38L3.17989763
3MAP4K12.96051247
4IRAK42.48479292
5MAP3K142.44058089
6NLK2.41273864
7TEC2.41002681
8TYK22.35268954
9JAK32.19004751
10EIF2AK32.13189711
11STK392.09785481
12BRSK21.95885704
13KIT1.95146474
14IKBKE1.85886816
15FGFR41.83744306
16JAK11.80017990
17IRAK31.78195804
18FGFR31.74816192
19FGFR21.70966287
20CDK121.65708261
21TGFBR21.65569417
22WNK41.59356981
23ZAP701.57547114
24MKNK21.57527054
25TNIK1.56995035
26MAP3K21.54281985
27FRK1.52463170
28ITK1.51918836
29CSK1.50686846
30MAP2K31.50152753
31BTK1.49716704
32TAOK31.46941095
33ACVR1B1.46653463
34BMPR1B1.45152262
35TBK11.44000494
36PIM11.43554170
37NUAK11.43457219
38ICK1.43230248
39STK101.43010476
40PDGFRA1.39956805
41CDK61.38725393
42WNK31.38342156
43IKBKB1.38116603
44ZAK1.36357285
45WNK11.33689897
46SCYL21.31525379
47MAP3K121.31086652
48CHUK1.26512274
49RPS6KA41.26390221
50LATS11.26149470
51MKNK11.26081799
52FGFR11.24209046
53CASK1.17605675
54TYRO31.13824113
55RET1.11939193
56FER1.08346428
57PBK1.06598016
58CSF1R1.06569227
59STK31.04840484
60HCK1.04611692
61EIF2AK21.04398682
62YES11.04161432
63SIK11.03261386
64LCK1.03232247
65CAMK1D1.03141507
66FLT31.03129349
67NEK91.02209145
68MAP3K101.00321717
69CDK40.92273827
70BCR0.91911852
71BRD40.91226020
72TIE10.88419498
73PTK60.87250614
74EEF2K0.87237916
75JAK20.86478741
76STK380.85879535
77EPHA30.84544063
78SYK0.83652058
79STK40.80938752
80SGK4940.77925033
81SGK2230.77925033
82ERBB30.76404101
83NME20.76145536
84SGK30.75200412
85MAP3K60.74708092
86CAMKK20.72962098
87RPS6KB20.72914974
88PNCK0.72644846
89LYN0.71206255
90MATK0.67451753
91ERN10.65490455
92MAP3K30.65073264
93NEK20.64163428
94ATR0.63217059
95INSRR0.63061260
96SGK20.62550986
97MAPK110.61929940
98MST40.61315755
99PINK10.61041725
100MET0.59680462
101CAMK1G0.59147240
102PIK3CA0.58929673
103MELK0.58262189
104NEK60.57740335
105MAPK130.57115501
106GRK60.55146216
107PRKCE0.54923059
108TRPM70.53748660
109PLK40.53570852
110TGFBR10.53076522
111AKT30.52859758
112CDK90.52638937
113LRRK20.52619009
114IRAK10.52608002
115FES0.52234770
116MARK30.52063605
117ERBB20.51601586
118NTRK30.50952772
119STK240.49175425
120CSNK1G10.48372087
121MAP3K40.47898848
122SGK10.46240471
123MST1R0.45962370
124PRKAA20.45890298
125ABL10.45841435
126PDGFRB0.45481163
127PDK10.45022995
128MAP2K60.41522197
129SRPK10.41478503
130CDK30.41417388
131RPS6KB10.41367158
132WEE10.41359767
133PRKD30.40448942
134CSNK1E0.40078148
135PKN20.38869946
136IGF1R0.38780663
137PRKAA10.38618393
138MAP3K70.38563922
139ATM0.37858062
140PDPK10.37736161
141PDK20.37388878
142PRKG20.36982890
143OXSR10.36939693
144HIPK20.36510880
145MAP2K10.34722850
146MAP2K40.33916521
147FGR0.33871218
148PIK3CG0.33672717
149EPHB10.33534955
150CAMK40.33070120
151KSR20.32190608

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000612.59711861
2Primary immunodeficiency_Homo sapiens_hsa053402.52364188
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.39986821
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.33177875
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26376838
6Fat digestion and absorption_Homo sapiens_hsa049752.20709356
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.19351797
8Measles_Homo sapiens_hsa051622.11935689
9Leishmaniasis_Homo sapiens_hsa051402.09011798
10Staphylococcus aureus infection_Homo sapiens_hsa051502.07660156
11Caffeine metabolism_Homo sapiens_hsa002321.92677838
12Butanoate metabolism_Homo sapiens_hsa006501.89900221
13Allograft rejection_Homo sapiens_hsa053301.87638299
14Propanoate metabolism_Homo sapiens_hsa006401.85209405
15Dorso-ventral axis formation_Homo sapiens_hsa043201.82541504
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82056706
17Herpes simplex infection_Homo sapiens_hsa051681.69910869
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62382596
19Hematopoietic cell lineage_Homo sapiens_hsa046401.60710539
20Fatty acid metabolism_Homo sapiens_hsa012121.59944551
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58327226
22Steroid biosynthesis_Homo sapiens_hsa001001.57980110
23Selenocompound metabolism_Homo sapiens_hsa004501.55017282
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.53287084
25Osteoclast differentiation_Homo sapiens_hsa043801.50666591
26Influenza A_Homo sapiens_hsa051641.48649999
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46710386
28Antigen processing and presentation_Homo sapiens_hsa046121.40523552
29T cell receptor signaling pathway_Homo sapiens_hsa046601.35979289
30One carbon pool by folate_Homo sapiens_hsa006701.35859743
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35591301
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35455148
33Legionellosis_Homo sapiens_hsa051341.34153790
34Circadian rhythm_Homo sapiens_hsa047101.33768418
35Autoimmune thyroid disease_Homo sapiens_hsa053201.32549214
36Toxoplasmosis_Homo sapiens_hsa051451.31004866
37B cell receptor signaling pathway_Homo sapiens_hsa046621.30864587
38Complement and coagulation cascades_Homo sapiens_hsa046101.30739613
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30614175
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.27942853
41Asthma_Homo sapiens_hsa053101.21748464
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19551717
43TNF signaling pathway_Homo sapiens_hsa046681.19057491
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17807696
45Graft-versus-host disease_Homo sapiens_hsa053321.17228022
46Acute myeloid leukemia_Homo sapiens_hsa052211.14897408
47ABC transporters_Homo sapiens_hsa020101.12511685
48Lysine degradation_Homo sapiens_hsa003101.10991415
49Non-homologous end-joining_Homo sapiens_hsa034501.04915986
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04885353
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03758251
52Hepatitis C_Homo sapiens_hsa051601.03188994
53Vitamin digestion and absorption_Homo sapiens_hsa049771.02749179
54Malaria_Homo sapiens_hsa051441.00950719
55Ether lipid metabolism_Homo sapiens_hsa005650.98888690
56Pertussis_Homo sapiens_hsa051330.98479971
57Tryptophan metabolism_Homo sapiens_hsa003800.96928238
58Small cell lung cancer_Homo sapiens_hsa052220.94862707
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.94499676
60Bile secretion_Homo sapiens_hsa049760.93366217
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93273561
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93110097
63Arginine biosynthesis_Homo sapiens_hsa002200.92115276
64Hepatitis B_Homo sapiens_hsa051610.91821156
65mTOR signaling pathway_Homo sapiens_hsa041500.91755946
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.91574619
67Non-small cell lung cancer_Homo sapiens_hsa052230.90730311
68Sphingolipid metabolism_Homo sapiens_hsa006000.90147545
69DNA replication_Homo sapiens_hsa030300.87874321
70Tuberculosis_Homo sapiens_hsa051520.87135754
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86864459
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86724730
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86474706
74Glycerolipid metabolism_Homo sapiens_hsa005610.85758728
75Systemic lupus erythematosus_Homo sapiens_hsa053220.85454695
76Apoptosis_Homo sapiens_hsa042100.85401568
77Inositol phosphate metabolism_Homo sapiens_hsa005620.83106239
78Thyroid cancer_Homo sapiens_hsa052160.81772581
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.81656031
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81394111
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76781863
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.76301622
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75748328
84ECM-receptor interaction_Homo sapiens_hsa045120.75592985
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75534525
86Thyroid hormone synthesis_Homo sapiens_hsa049180.74874101
87beta-Alanine metabolism_Homo sapiens_hsa004100.73601693
88p53 signaling pathway_Homo sapiens_hsa041150.72740935
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71929247
90Starch and sucrose metabolism_Homo sapiens_hsa005000.71916627
91Fatty acid degradation_Homo sapiens_hsa000710.71605442
92Renin-angiotensin system_Homo sapiens_hsa046140.69808179
93Viral carcinogenesis_Homo sapiens_hsa052030.69174422
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68671887
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68663887
96Linoleic acid metabolism_Homo sapiens_hsa005910.68409414
97Insulin resistance_Homo sapiens_hsa049310.68356709
98Nitrogen metabolism_Homo sapiens_hsa009100.68331952
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68202376
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67442934
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66636517
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.65980298
103Viral myocarditis_Homo sapiens_hsa054160.65353264
104Proteoglycans in cancer_Homo sapiens_hsa052050.64599257
105Base excision repair_Homo sapiens_hsa034100.64461129
106Peroxisome_Homo sapiens_hsa041460.63262798
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61776846
108PPAR signaling pathway_Homo sapiens_hsa033200.61776660
109Platelet activation_Homo sapiens_hsa046110.60258831
110Chemokine signaling pathway_Homo sapiens_hsa040620.59876161
111TGF-beta signaling pathway_Homo sapiens_hsa043500.59740657
112Adherens junction_Homo sapiens_hsa045200.57725995
113Chronic myeloid leukemia_Homo sapiens_hsa052200.57339991
114HTLV-I infection_Homo sapiens_hsa051660.57224415
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56638407
116Histidine metabolism_Homo sapiens_hsa003400.55748017
117Choline metabolism in cancer_Homo sapiens_hsa052310.55521717
118Other glycan degradation_Homo sapiens_hsa005110.55241680
119Renin secretion_Homo sapiens_hsa049240.54973969
120Prostate cancer_Homo sapiens_hsa052150.54344903
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53413557
122Mismatch repair_Homo sapiens_hsa034300.52430025
123FoxO signaling pathway_Homo sapiens_hsa040680.51825584
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51674024
125African trypanosomiasis_Homo sapiens_hsa051430.51445751
126Focal adhesion_Homo sapiens_hsa045100.51107672
127Renal cell carcinoma_Homo sapiens_hsa052110.50975422
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50774406
129Retinol metabolism_Homo sapiens_hsa008300.49730116
130Pancreatic cancer_Homo sapiens_hsa052120.49138884
131Glucagon signaling pathway_Homo sapiens_hsa049220.48267212
132MicroRNAs in cancer_Homo sapiens_hsa052060.46755426
133Endometrial cancer_Homo sapiens_hsa052130.45629322
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45028865
135Fanconi anemia pathway_Homo sapiens_hsa034600.44745765
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44119332
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43501106
138Pancreatic secretion_Homo sapiens_hsa049720.43061206
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42903447
140Mineral absorption_Homo sapiens_hsa049780.42806610
141Amoebiasis_Homo sapiens_hsa051460.42645860
142N-Glycan biosynthesis_Homo sapiens_hsa005100.42361970
143Salmonella infection_Homo sapiens_hsa051320.41258545
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.41092265
145Chemical carcinogenesis_Homo sapiens_hsa052040.40200009
146Prolactin signaling pathway_Homo sapiens_hsa049170.40068055
147Protein digestion and absorption_Homo sapiens_hsa049740.39266113
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38924726
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38118054
150Phenylalanine metabolism_Homo sapiens_hsa003600.37247648
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.37035365
152Type II diabetes mellitus_Homo sapiens_hsa049300.36650482
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35698835
154Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34116847
155Insulin signaling pathway_Homo sapiens_hsa049100.33837688

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