VPS4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.59771871
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83529002
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.83529002
4antigen processing and presentation of endogenous antigen (GO:0019883)4.33508609
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08268352
6negative regulation of cell killing (GO:0031342)4.08268352
7positive regulation of gamma-delta T cell activation (GO:0046645)3.80511881
8keratinization (GO:0031424)3.74691866
9neutrophil activation involved in immune response (GO:0002283)3.62841580
10cellular response to interleukin-15 (GO:0071350)3.48336666
11Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31760108
12positive regulation of interferon-alpha production (GO:0032727)3.28065216
13positive regulation of toll-like receptor signaling pathway (GO:0034123)3.26753240
14production of molecular mediator involved in inflammatory response (GO:0002532)3.26468098
15negative regulation of T cell mediated immunity (GO:0002710)3.15894484
16regulation of interferon-beta biosynthetic process (GO:0045357)3.13189571
17antigen processing and presentation via MHC class Ib (GO:0002475)3.12695828
18immunoglobulin mediated immune response (GO:0016064)3.12106347
19regulation of interferon-alpha production (GO:0032647)3.10439840
20positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10293892
21detection of molecule of bacterial origin (GO:0032490)3.06248710
22response to interleukin-15 (GO:0070672)3.04638994
23regulation of T cell mediated cytotoxicity (GO:0001914)3.01673925
24negative T cell selection (GO:0043383)3.01392938
25regulation of regulatory T cell differentiation (GO:0045589)3.00058775
26activated T cell proliferation (GO:0050798)2.99360015
27hepatocyte apoptotic process (GO:0097284)2.98417450
28negative regulation of interleukin-12 production (GO:0032695)2.97627959
29neutrophil mediated immunity (GO:0002446)2.95590904
30detection of external biotic stimulus (GO:0098581)2.95165720
31negative regulation of interleukin-17 production (GO:0032700)2.94545417
32cellular response to ethanol (GO:0071361)2.91676634
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91657101
34positive regulation of B cell differentiation (GO:0045579)2.91623327
35B cell mediated immunity (GO:0019724)2.91621657
36regulation of gamma-delta T cell differentiation (GO:0045586)2.90515306
37keratinocyte development (GO:0003334)2.89976671
38negative thymic T cell selection (GO:0045060)2.88904981
39regulation of memory T cell differentiation (GO:0043380)2.85600702
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84910176
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84910176
42positive regulation by organism of defense response of other organism involved in symbiotic interact2.84910176
43modulation by symbiont of host immune response (GO:0052553)2.84910176
44positive regulation by symbiont of host defense response (GO:0052509)2.84910176
45modulation by symbiont of host defense response (GO:0052031)2.84910176
46respiratory burst (GO:0045730)2.82759323
47regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.77900203
48negative regulation of lymphocyte mediated immunity (GO:0002707)2.77222536
49microglial cell activation (GO:0001774)2.76365166
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74139902
51regulation of gamma-delta T cell activation (GO:0046643)2.71211069
52negative regulation of B cell proliferation (GO:0030889)2.71130968
53leukocyte aggregation (GO:0070486)2.69295045
54detection of biotic stimulus (GO:0009595)2.66311592
55G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.65217848
56regulation of interleukin-17 production (GO:0032660)2.64798078
57positive regulation of humoral immune response (GO:0002922)2.63318480
58regulation of interleukin-12 biosynthetic process (GO:0045075)2.62547899
59neutrophil activation (GO:0042119)2.62058544
60response to interferon-alpha (GO:0035455)2.61566315
61positive regulation of macrophage differentiation (GO:0045651)2.61516465
62positive regulation of interferon-beta production (GO:0032728)2.61079678
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60611369
64regulation of tolerance induction (GO:0002643)2.60546298
65regulation of B cell differentiation (GO:0045577)2.59258121
66positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58733153
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58564483
68granulocyte activation (GO:0036230)2.57699120
69pyrimidine-containing compound transmembrane transport (GO:0072531)2.57572253
70intestinal epithelial cell development (GO:0060576)2.55821774
71regulation of leukocyte mediated cytotoxicity (GO:0001910)2.55660637
72regulation of natural killer cell differentiation (GO:0032823)2.55272584
73response to interferon-beta (GO:0035456)2.55245263
74B cell proliferation (GO:0042100)2.55194777
75establishment of skin barrier (GO:0061436)2.55029506
76positive regulation of granulocyte differentiation (GO:0030854)2.54484387
77leukocyte degranulation (GO:0043299)2.52860534
78response to type I interferon (GO:0034340)2.52701390
79regulation of mast cell activation (GO:0033003)2.52113668
80neural tube formation (GO:0001841)2.52016406
81positive regulation of interleukin-1 beta secretion (GO:0050718)2.51685461
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.50321213
83ribosomal small subunit assembly (GO:0000028)2.50116754
84desmosome organization (GO:0002934)2.49893855
85positive regulation of tolerance induction (GO:0002645)2.49207505
86actin nucleation (GO:0045010)2.48973119
87positive regulation of T cell chemotaxis (GO:0010820)2.48420428
88regulation of T cell chemotaxis (GO:0010819)2.48420428
89production of molecular mediator of immune response (GO:0002440)2.48381044
90macrophage activation (GO:0042116)2.47793088
91myeloid leukocyte mediated immunity (GO:0002444)2.47776905
92natural killer cell activation involved in immune response (GO:0002323)2.47411605
93megakaryocyte development (GO:0035855)2.47380465
94interferon-gamma secretion (GO:0072643)2.47194771
95regulation of B cell receptor signaling pathway (GO:0050855)2.46457489
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.46284805
97cellular response to type I interferon (GO:0071357)2.46173031
98type I interferon signaling pathway (GO:0060337)2.46173031
99detection of other organism (GO:0098543)2.45244327
100response to peptidoglycan (GO:0032494)2.45131813
101positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.44535294
102positive regulation of natural killer cell differentiation (GO:0032825)2.43569082
103JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.42191219
104positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35053255
105detection of bacterium (GO:0016045)2.31494272
106sequestering of metal ion (GO:0051238)2.31419103
107natural killer cell mediated cytotoxicity (GO:0042267)2.29908963
108natural killer cell mediated immunity (GO:0002228)2.29908963
109COPI coating of Golgi vesicle (GO:0048205)2.28810070
110Golgi transport vesicle coating (GO:0048200)2.28810070
111defense response to protozoan (GO:0042832)2.28145398
112response to protozoan (GO:0001562)2.25723834
113T-helper 1 type immune response (GO:0042088)2.23988943
114regulation of response to interferon-gamma (GO:0060330)2.23809448
115NIK/NF-kappaB signaling (GO:0038061)2.23598897
116cytokine secretion (GO:0050663)2.23133969
117myeloid cell activation involved in immune response (GO:0002275)2.21633933
118signal peptide processing (GO:0006465)2.20884440
119wound healing, spreading of epidermal cells (GO:0035313)2.20272044
120necroptotic process (GO:0070266)2.19669364
121cellular response to interferon-beta (GO:0035458)2.18122932
122regulation of type I interferon-mediated signaling pathway (GO:0060338)2.17623799
123pinocytosis (GO:0006907)2.17595846
124lipopolysaccharide-mediated signaling pathway (GO:0031663)2.16759210
125interferon-gamma-mediated signaling pathway (GO:0060333)2.14940121
126negative regulation of glycoprotein biosynthetic process (GO:0010561)2.14875797
127myeloid dendritic cell activation (GO:0001773)2.13629928
128regulation of alpha-beta T cell proliferation (GO:0046640)2.13581002
129regulation of interferon-beta production (GO:0032648)2.13220701
130positive regulation of antigen processing and presentation (GO:0002579)2.11895515
131dendritic cell migration (GO:0036336)2.11160786
132positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.10590535
133regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.09914792
134regulation of necroptotic process (GO:0060544)2.08712230
135folic acid-containing compound biosynthetic process (GO:0009396)2.08528520
136response to muramyl dipeptide (GO:0032495)2.08180176
137positive regulation of alpha-beta T cell proliferation (GO:0046641)2.08168524
138B cell receptor signaling pathway (GO:0050853)2.07749943
139definitive hemopoiesis (GO:0060216)2.07213121
140macrophage activation involved in immune response (GO:0002281)2.06647076
141cellular response to zinc ion (GO:0071294)2.03694802
142leukocyte cell-cell adhesion (GO:0007159)2.03046902
143wound healing, spreading of cells (GO:0044319)2.02056086
144positive regulation of Cdc42 GTPase activity (GO:0043089)2.01187472
145T cell apoptotic process (GO:0070231)2.00718254
146thrombin receptor signaling pathway (GO:0070493)2.00657652
147lymphocyte mediated immunity (GO:0002449)1.99965003
148dendritic cell chemotaxis (GO:0002407)1.99228928
149cellular response to exogenous dsRNA (GO:0071360)1.98783730
150mast cell activation (GO:0045576)1.97408518
151positive regulation of protein import into nucleus, translocation (GO:0033160)1.96402858
152cellular extravasation (GO:0045123)1.95816450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.28642278
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.18188223
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.21537211
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.12743128
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.09559644
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91351063
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90187044
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59645855
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.56115972
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49917974
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37946592
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36036464
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32492435
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26735898
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.22685134
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20045435
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19171767
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18014681
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.08201846
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06196763
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06151390
22SCL_19346495_ChIP-Seq_HPC-7_Human2.05627443
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03491237
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.02282575
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96447318
26* SPI1_23547873_ChIP-Seq_NB4_Human1.94082061
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89140093
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88843741
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87292838
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85340107
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81929053
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81746858
33MYB_26560356_Chip-Seq_TH2_Human1.81476800
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80451977
35GATA1_22025678_ChIP-Seq_K562_Human1.77312926
36* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75171674
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73129599
38* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71025316
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70684333
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69208358
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67333363
42VDR_24787735_ChIP-Seq_THP-1_Human1.66713727
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.65712816
44VDR_22108803_ChIP-Seq_LS180_Human1.64822066
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62490157
46MYC_22102868_ChIP-Seq_BL_Human1.59620842
47MAF_26560356_Chip-Seq_TH1_Human1.58808749
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.58751092
49MYB_26560356_Chip-Seq_TH1_Human1.57705036
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57312679
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56913649
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55031502
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54955133
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54915508
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53728993
56VDR_21846776_ChIP-Seq_THP-1_Human1.50530451
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49538646
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49165957
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48284711
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47510388
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.47453246
62* EZH2_27294783_Chip-Seq_NPCs_Mouse1.45241508
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43408125
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.43293821
65VDR_24763502_ChIP-Seq_THP-1_Human1.42898995
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42571693
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41237269
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40944550
69* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40111732
70RUNX_20019798_ChIP-Seq_JUKART_Human1.39524138
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.36324550
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.35467182
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34016184
74* NFE2_27457419_Chip-Seq_LIVER_Mouse1.33175581
75EWS_26573619_Chip-Seq_HEK293_Human1.32713144
76UTX_26944678_Chip-Seq_JUKART_Human1.31599810
77* TP63_23658742_ChIP-Seq_EP156T_Human1.30189552
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29567127
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27964652
80CDX2_22108803_ChIP-Seq_LS180_Human1.26933623
81ER_23166858_ChIP-Seq_MCF-7_Human1.25999898
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25594808
83ZNF274_21170338_ChIP-Seq_K562_Hela1.24881288
84* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24501674
85P300_19829295_ChIP-Seq_ESCs_Human1.23552619
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23096603
87AR_21909140_ChIP-Seq_LNCAP_Human1.21042156
88* PU_27001747_Chip-Seq_BMDM_Mouse1.19481345
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18185247
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18185247
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17863615
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17789680
93GATA3_27048872_Chip-Seq_THYMUS_Human1.17775246
94TFEB_21752829_ChIP-Seq_HELA_Human1.17771929
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17751221
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17251665
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17196538
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16040566
99TAF15_26573619_Chip-Seq_HEK293_Human1.15612961
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15488680
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14651616
102* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13492478
103TCF7_22412390_ChIP-Seq_EML_Mouse1.13154318
104* NANOG_18555785_Chip-Seq_ESCs_Mouse1.13021907
105ELK1_19687146_ChIP-ChIP_HELA_Human1.12778219
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12678929
107FUS_26573619_Chip-Seq_HEK293_Human1.12205000
108* CRX_20693478_ChIP-Seq_RETINA_Mouse1.11493779
109BCAT_22108803_ChIP-Seq_LS180_Human1.10881938
110* P53_22387025_ChIP-Seq_ESCs_Mouse1.10492594
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10074734
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09913092
113LXR_22158963_ChIP-Seq_LIVER_Mouse1.09864193
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09834181
115GABP_17652178_ChIP-ChIP_JURKAT_Human1.09453960
116* VDR_23849224_ChIP-Seq_CD4+_Human1.09079361
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08857348
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08750501
119* P300_18555785_Chip-Seq_ESCs_Mouse1.08058020
120* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07284390
121CLOCK_20551151_ChIP-Seq_293T_Human1.06949717
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06544933
123* CMYC_18555785_Chip-Seq_ESCs_Mouse1.06295306
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06284137
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06066214
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.06044699
127NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05628858
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05628858
129* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05269650
130* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05263753
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04918057
132* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04816000
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04715768
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03904126
135IGF1R_20145208_ChIP-Seq_DFB_Human1.03585939
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03528993
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03324892
138PIAS1_25552417_ChIP-Seq_VCAP_Human1.02104204
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00332334
140* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00258741
141GATA2_21666600_ChIP-Seq_HMVEC_Human0.99439288
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99316176
143* OCT4_18555785_Chip-Seq_ESCs_Mouse0.99105476
144CJUN_26792858_Chip-Seq_BT549_Human0.99095343
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98833744
146* STAT3_18555785_Chip-Seq_ESCs_Mouse0.98601497
147TCF4_22108803_ChIP-Seq_LS180_Human0.98478781
148FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98056083
149GATA3_26560356_Chip-Seq_TH2_Human0.97942083
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97941115
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97598292
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96404714
153TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96010590
154NOTCH1_21737748_ChIP-Seq_TLL_Human0.94388396
155ZNF263_19887448_ChIP-Seq_K562_Human0.94125462
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93714944
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93546813
158GATA6_25053715_ChIP-Seq_YYC3_Human0.92614593
159ELK3_25401928_ChIP-Seq_HUVEC_Human0.92146484
160E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90685689
161GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88372874
162E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86024775
163DCP1A_22483619_ChIP-Seq_HELA_Human0.85121218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.30177407
2MP0001835_abnormal_antigen_presentation2.91958583
3MP0003436_decreased_susceptibility_to2.56813203
4MP0003724_increased_susceptibility_to2.48397592
5MP0009785_altered_susceptibility_to2.43948889
6MP0000685_abnormal_immune_system2.22995334
7MP0004381_abnormal_hair_follicle2.18643296
8MP0005075_abnormal_melanosome_morpholog2.16477607
9MP0002166_altered_tumor_susceptibility2.12469889
10MP0004947_skin_inflammation2.06582786
11MP0005000_abnormal_immune_tolerance2.04622662
12MP0005025_abnormal_response_to2.00912012
13MP0010352_gastrointestinal_tract_polyps1.96980335
14MP0002148_abnormal_hypersensitivity_rea1.96966427
15MP0002419_abnormal_innate_immunity1.96665594
16MP0003300_gastrointestinal_ulcer1.90566433
17MP0005671_abnormal_response_to1.89800529
18MP0001800_abnormal_humoral_immune1.89351447
19MP0006054_spinal_hemorrhage1.87436308
20MP0002006_tumorigenesis1.86212648
21MP0006082_CNS_inflammation1.84491596
22MP0002452_abnormal_antigen_presenting1.83815554
23MP0000383_abnormal_hair_follicle1.82453082
24MP0003191_abnormal_cellular_cholesterol1.79531049
25MP0002396_abnormal_hematopoietic_system1.78570957
26MP0005387_immune_system_phenotype1.78416503
27MP0001790_abnormal_immune_system1.78416503
28MP0002723_abnormal_immune_serum1.78217507
29MP0005464_abnormal_platelet_physiology1.77890601
30MP0010155_abnormal_intestine_physiology1.73406210
31MP0001853_heart_inflammation1.72732009
32MP0010678_abnormal_skin_adnexa1.68754924
33MP0003806_abnormal_nucleotide_metabolis1.65573801
34MP0001819_abnormal_immune_cell1.65138672
35MP0002420_abnormal_adaptive_immunity1.64840183
36MP0005058_abnormal_lysosome_morphology1.63809346
37MP0000465_gastrointestinal_hemorrhage1.60528790
38MP0003303_peritoneal_inflammation1.59440605
39MP0003828_pulmonary_edema1.56051558
40MP0000427_abnormal_hair_cycle1.49914390
41MP0009840_abnormal_foam_cell1.48261825
42MP0001845_abnormal_inflammatory_respons1.46898242
43MP0002405_respiratory_system_inflammati1.45316026
44MP0008877_abnormal_DNA_methylation1.44370926
45MP0001851_eye_inflammation1.44335011
46MP0000858_altered_metastatic_potential1.43737992
47MP0001545_abnormal_hematopoietic_system1.43113400
48MP0005397_hematopoietic_system_phenotyp1.43113400
49MP0000015_abnormal_ear_pigmentation1.41331749
50MP0009278_abnormal_bone_marrow1.40774556
51MP0002398_abnormal_bone_marrow1.40235141
52MP0002877_abnormal_melanocyte_morpholog1.38873591
53MP0003453_abnormal_keratinocyte_physiol1.36286791
54MP0000490_abnormal_crypts_of1.35620432
55MP0003763_abnormal_thymus_physiology1.35222457
56MP0000716_abnormal_immune_system1.33597287
57MP0002139_abnormal_hepatobiliary_system1.33267572
58MP0001873_stomach_inflammation1.30892298
59MP0003693_abnormal_embryo_hatching1.30231459
60MP0001533_abnormal_skeleton_physiology1.28156386
61MP0008469_abnormal_protein_level1.28145241
62MP0002876_abnormal_thyroid_physiology1.28055645
63MP0003866_abnormal_defecation1.27497227
64MP0005360_urolithiasis1.27256884
65MP0000689_abnormal_spleen_morphology1.27192273
66MP0003195_calcinosis1.24997021
67MP0002722_abnormal_immune_system1.23944924
68MP0003566_abnormal_cell_adhesion1.20034992
69MP0002254_reproductive_system_inflammat1.19705676
70MP0001216_abnormal_epidermal_layer1.17639121
71MP0009333_abnormal_splenocyte_physiolog1.16623258
72MP0002277_abnormal_respiratory_mucosa1.16485836
73MP0002429_abnormal_blood_cell1.16052240
74MP0002796_impaired_skin_barrier1.14733728
75MP0003705_abnormal_hypodermis_morpholog1.13286059
76MP0010307_abnormal_tumor_latency1.12486216
77MP0004883_abnormal_blood_vessel1.12370063
78MP0004264_abnormal_extraembryonic_tissu1.11733971
79MP0003448_altered_tumor_morphology1.11022622
80MP0004808_abnormal_hematopoietic_stem1.10703647
81MP0002095_abnormal_skin_pigmentation1.10576095
82MP0005023_abnormal_wound_healing1.09981352
83MP0002138_abnormal_hepatobiliary_system1.09657367
84MP0005310_abnormal_salivary_gland1.08960879
85MP0005164_abnormal_response_to1.08831434
86MP0001666_abnormal_nutrient_absorption1.08704155
87MP0003186_abnormal_redox_activity1.02712981
88MP0003941_abnormal_skin_development1.02434703
89MP0002060_abnormal_skin_morphology1.00621934
90MP0009764_decreased_sensitivity_to0.99400107
91MP0000371_diluted_coat_color0.99081529
92MP0005365_abnormal_bile_salt0.97100756
93MP0003172_abnormal_lysosome_physiology0.96727700
94MP0000609_abnormal_liver_physiology0.96165751
95MP0005408_hypopigmentation0.94659511
96MP0005084_abnormal_gallbladder_morpholo0.94377817
97MP0005174_abnormal_tail_pigmentation0.92598786
98MP0005085_abnormal_gallbladder_physiolo0.92189330
99MP0005076_abnormal_cell_differentiation0.91712718
100MP0002019_abnormal_tumor_incidence0.90764178
101MP0002009_preneoplasia0.89794435
102MP0001191_abnormal_skin_condition0.88303562
103MP0000569_abnormal_digit_pigmentation0.87260326
104MP0002098_abnormal_vibrissa_morphology0.87149377
105MP0000703_abnormal_thymus_morphology0.85366328
106MP0003252_abnormal_bile_duct0.85250363
107MP0003656_abnormal_erythrocyte_physiolo0.84741005
108MP0000377_abnormal_hair_follicle0.84300372
109MP0009763_increased_sensitivity_to0.84088144
110MP0005501_abnormal_skin_physiology0.83161697
111MP0005275_abnormal_skin_tensile0.80746085
112MP0008007_abnormal_cellular_replicative0.80650262
113MP0000477_abnormal_intestine_morphology0.80391321
114MP0009643_abnormal_urine_homeostasis0.79979593
115MP0004782_abnormal_surfactant_physiolog0.79688768
116MP0009765_abnormal_xenobiotic_induced0.79115998
117MP0002136_abnormal_kidney_physiology0.78039473
118MP0005319_abnormal_enzyme/_coenzyme0.77586464
119MP0000598_abnormal_liver_morphology0.77554874
120MP0003183_abnormal_peptide_metabolism0.75929440
121MP0010386_abnormal_urinary_bladder0.75142642
122MP0002998_abnormal_bone_remodeling0.73933813
123MP0001663_abnormal_digestive_system0.72110299
124MP0008057_abnormal_DNA_replication0.71564611
125MP0000579_abnormal_nail_morphology0.70565364
126MP0001765_abnormal_ion_homeostasis0.69462125
127MP0000372_irregular_coat_pigmentation0.69411790
128MP0005166_decreased_susceptibility_to0.67998534

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.46239091
2Recurrent abscess formation (HP:0002722)4.39505128
3Recurrent bacterial skin infections (HP:0005406)4.27296630
4Autoimmune thrombocytopenia (HP:0001973)3.83433044
5Elevated erythrocyte sedimentation rate (HP:0003565)3.78851039
6Myositis (HP:0100614)3.76879931
7Palmoplantar hyperkeratosis (HP:0000972)3.37792384
8Thyroiditis (HP:0100646)3.34750026
9Plantar hyperkeratosis (HP:0007556)3.26465923
10Palmar hyperkeratosis (HP:0010765)3.22934314
11Recurrent gram-negative bacterial infections (HP:0005420)3.21014211
12Thrombocytosis (HP:0001894)3.11561637
13Abnormality of macrophages (HP:0004311)3.07052579
14Periodontitis (HP:0000704)3.06666562
15Keratoconjunctivitis (HP:0001096)3.01688934
16Vacuolated lymphocytes (HP:0001922)3.01055888
17Oral leukoplakia (HP:0002745)3.00147676
18Pustule (HP:0200039)2.99720566
19Hematochezia (HP:0002573)2.97290288
20Abnormality of nail color (HP:0100643)2.92626012
21Orchitis (HP:0100796)2.92524364
22Interstitial pulmonary disease (HP:0006530)2.88372799
23Recurrent viral infections (HP:0004429)2.84758835
24Recurrent fungal infections (HP:0002841)2.81874320
25Erythroderma (HP:0001019)2.75280986
26Pulmonary infiltrates (HP:0002113)2.74907031
27Recurrent skin infections (HP:0001581)2.70990563
28Chronic otitis media (HP:0000389)2.70947843
29Hypoproteinemia (HP:0003075)2.68448714
30Abnormality of T cell number (HP:0011839)2.67935363
31Thick nail (HP:0001805)2.64529750
32T lymphocytopenia (HP:0005403)2.61699383
33Abnormality of eosinophils (HP:0001879)2.61056629
34Parakeratosis (HP:0001036)2.60642863
35Severe combined immunodeficiency (HP:0004430)2.59665405
36Panhypogammaglobulinemia (HP:0003139)2.58750681
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.53993287
38Osteolytic defects of the hand bones (HP:0009699)2.53993287
39IgG deficiency (HP:0004315)2.49481917
40Mediastinal lymphadenopathy (HP:0100721)2.48924132
41Increased cerebral lipofuscin (HP:0011813)2.48378712
42Gingival bleeding (HP:0000225)2.47859338
43Stomach cancer (HP:0012126)2.45961108
44Spontaneous hematomas (HP:0007420)2.40823633
45Vasculitis (HP:0002633)2.40795635
46Retrobulbar optic neuritis (HP:0100654)2.40716500
47Optic neuritis (HP:0100653)2.40716500
48Abnormality of T cells (HP:0002843)2.40577675
49Hemoptysis (HP:0002105)2.40482195
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.40341895
51Cellulitis (HP:0100658)2.40321000
52Autoimmune hemolytic anemia (HP:0001890)2.40145466
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.39232369
54Abnormality of T cell physiology (HP:0011840)2.35144448
55Petechiae (HP:0000967)2.34719985
56Encephalitis (HP:0002383)2.31279700
57Alopecia of scalp (HP:0002293)2.30776705
58Abnormality of secondary sexual hair (HP:0009888)2.28692048
59Abnormality of the axillary hair (HP:0100134)2.28692048
60Abnormal platelet volume (HP:0011876)2.26633651
61Osteomyelitis (HP:0002754)2.24195018
62Increased mean platelet volume (HP:0011877)2.23357783
63Abnormality of glycolipid metabolism (HP:0010969)2.22527684
64Abnormality of liposaccharide metabolism (HP:0010968)2.22527684
65Abnormality of glycosphingolipid metabolism (HP:0004343)2.22527684
66IgM deficiency (HP:0002850)2.22294919
67Dry hair (HP:0011359)2.20326784
68Skin ulcer (HP:0200042)2.19931747
69Arterial thrombosis (HP:0004420)2.18747328
70Onycholysis (HP:0001806)2.17585127
71Increased IgE level (HP:0003212)2.16043655
72Leukocytosis (HP:0001974)2.15643218
73Epistaxis (HP:0000421)2.15498427
74Agnosia (HP:0010524)2.15297292
75Eosinophilia (HP:0001880)2.10920395
76Myocardial infarction (HP:0001658)2.10622538
77Congenital sensorineural hearing impairment (HP:0008527)2.09744196
78Chronic diarrhea (HP:0002028)2.09425275
79Combined immunodeficiency (HP:0005387)2.08815179
80Systemic lupus erythematosus (HP:0002725)2.08720861
81Curly hair (HP:0002212)2.08483269
82Cheilitis (HP:0100825)2.07452445
83Recurrent bronchitis (HP:0002837)2.07195194
84Erythema (HP:0010783)2.07110358
85Gingivitis (HP:0000230)2.05262653
86Neoplasm of the tracheobronchial system (HP:0100552)2.05156763
87Granulocytopenia (HP:0001913)2.03090078
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02499886
89Urticaria (HP:0001025)2.01479962
90Pruritus (HP:0000989)2.01105672
91Obstructive lung disease (HP:0006536)2.00784599
92Chronic obstructive pulmonary disease (HP:0006510)2.00784599
93Meningitis (HP:0001287)2.00681179
94Anhidrosis (HP:0000970)1.96958623
95Nephritis (HP:0000123)1.96739125
96Abnormality of monocarboxylic acid metabolism (HP:0010996)1.96446991
97Inflammation of the large intestine (HP:0002037)1.96222865
98Alveolar cell carcinoma (HP:0006519)1.96201819
99Reduced antithrombin III activity (HP:0001976)1.96199469
100Facial diplegia (HP:0001349)1.96099782
101Renal cortical cysts (HP:0000803)1.95990967
102Abnormality of the prostate (HP:0008775)1.95405255
103Impaired platelet aggregation (HP:0003540)1.95274940
104Abnormal platelet function (HP:0011869)1.95274940
105Ectropion (HP:0000656)1.92198358
106Gastrointestinal inflammation (HP:0004386)1.92188886
107Prostate neoplasm (HP:0100787)1.90547845
108Lymphopenia (HP:0001888)1.90329610
109Abnormality of the common coagulation pathway (HP:0010990)1.89801871
110Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89108408
111Abnormality of cells of the lymphoid lineage (HP:0012140)1.88943455
112Micronodular cirrhosis (HP:0001413)1.88898523
113Hypoplasia of the thymus (HP:0000778)1.88894069
114Dysostosis multiplex (HP:0000943)1.86699022
115Malnutrition (HP:0004395)1.86188948
116Prolonged bleeding time (HP:0003010)1.85597738
117Congenital ichthyosiform erythroderma (HP:0007431)1.85481780
118Spastic diplegia (HP:0001264)1.84006915
119Stomatitis (HP:0010280)1.83851669
120Keratoconjunctivitis sicca (HP:0001097)1.83355550
121Esophageal varix (HP:0002040)1.82656331
122Gastrointestinal infarctions (HP:0005244)1.82626361
123Purpura (HP:0000979)1.82458868
124Acute myeloid leukemia (HP:0004808)1.82304574
125Albinism (HP:0001022)1.81839624
126Glomerulonephritis (HP:0000099)1.81327666
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81080081
128Hypergammaglobulinemia (HP:0010702)1.80626569
129Milia (HP:0001056)1.80019334
130Fair hair (HP:0002286)1.79929264
131Abnormality of B cell number (HP:0010975)1.79050531
132B lymphocytopenia (HP:0010976)1.79050531
133Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.78969985
134Keratitis (HP:0000491)1.77957698
135Mucopolysacchariduria (HP:0008155)1.77294529
136Urinary glycosaminoglycan excretion (HP:0003541)1.77294529
137Abnormality of the nasal mucosa (HP:0000433)1.76943639
138Abnormality of the renal cortex (HP:0011035)1.76725262
139Hypothermia (HP:0002045)1.76694033
140Nasal polyposis (HP:0100582)1.76613950
141Disinhibition (HP:0000734)1.76535463
142Gangrene (HP:0100758)1.76382138
143Premature loss of primary teeth (HP:0006323)1.76333651
144Sepsis (HP:0100806)1.75941788
145Amaurosis fugax (HP:0100576)1.75728275
146Bronchitis (HP:0012387)1.75415700
147Anorexia (HP:0002039)1.75189507
148Lymphoma (HP:0002665)1.74846980
149Chronic sinusitis (HP:0011109)1.74528877
150Tetraparesis (HP:0002273)1.74267142
151Chronic mucocutaneous candidiasis (HP:0002728)1.73080025
152Recurrent cutaneous fungal infections (HP:0011370)1.73080025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST42.85037284
2MAP4K12.32260571
3FLT32.30026699
4ERN12.29765674
5MAP3K142.28964305
6STK102.28583092
7IRAK42.27757925
8TYK22.26630266
9BLK2.24904636
10STK242.17705538
11IRAK32.16192209
12TBK12.04865544
13TEC1.99200112
14ZAP701.93324570
15MAP2K31.92780352
16BMPR21.83437045
17MAP3K121.75742546
18BMPR1B1.75224569
19KIT1.73161218
20TGFBR21.72091816
21NUAK11.70823852
22LRRK21.69300239
23JAK31.68431721
24TXK1.63155634
25TRIM281.61444645
26EPHA21.59178568
27FES1.56421414
28MST1R1.55620650
29EEF2K1.50699275
30NEK91.50561845
31BTK1.50039277
32MAPKAPK31.44878594
33FRK1.42973009
34ADRBK21.41692143
35RPS6KA41.41470612
36ITK1.40782819
37IKBKE1.34012526
38RPS6KB21.33566001
39BRSK21.33030401
40TAOK31.32046220
41OXSR11.28683376
42JAK11.27733430
43IKBKB1.23677920
44STK391.23610557
45PIM21.21342493
46FGFR41.21082970
47RIPK11.20555303
48SCYL21.19144374
49FGR1.17553127
50PKN21.16751810
51NME21.16186354
52GRK11.16168107
53TRPM71.15701604
54PBK1.14457231
55NLK1.14382054
56CSK1.13491749
57PTK61.12939137
58MATK1.09375072
59CSF1R1.08668536
60RIPK41.06656887
61MAP3K31.06411945
62TNIK1.04153832
63CHUK1.02850487
64MAP3K10.99679517
65PIM10.99584850
66LCK0.98064484
67EPHA30.97663941
68MAP4K20.97082812
69EIF2AK30.95921365
70PASK0.95544272
71SYK0.93855326
72CDK60.91524947
73EPHB10.90872697
74WNK30.90710787
75YES10.90488873
76KDR0.88609866
77MAP3K80.88279473
78STK30.87757003
79ACVR1B0.87666377
80FER0.86143843
81SIK30.86061869
82MAP2K20.86027222
83WEE10.84721782
84TGFBR10.84540204
85PIK3CG0.83411409
86TLK10.82297663
87FGFR30.82070388
88MAP3K100.81828974
89STK40.80716176
90PRKCQ0.80166948
91JAK20.79070479
92MAP3K130.78658287
93PAK30.78321101
94PRKG20.77969240
95LYN0.77315459
96PAK40.75686986
97NEK20.70492197
98GRK60.70365207
99HCK0.70353131
100EIF2AK10.69194035
101STK38L0.69091614
102ZAK0.68992003
103MET0.65777771
104MAP2K60.65459025
105ADRBK10.63262272
106ABL10.63010847
107MELK0.63007715
108TESK10.62345545
109MKNK20.61778404
110IRAK20.57901615
111CAMK1D0.56324996
112GRK70.55920949
113PRKCE0.55299604
114MAP3K40.53399866
115CLK10.53239203
116ERBB30.51392591
117EIF2AK20.51080808
118MAPKAPK20.50348618
119AURKB0.49821410
120MARK30.49306400
121IRAK10.47247927
122BRD40.46818495
123NEK60.44746573
124BCKDK0.44198707
125MAPK70.41071872
126CAMKK20.39716490
127RPS6KA50.39178964
128CDK40.38778589
129CDK120.38727160
130TRIB30.38426996
131MAP3K20.36037689
132EGFR0.35676113
133MAP3K110.35499587
134PLK30.34981425
135IGF1R0.34845198
136PTK20.33801156
137PLK20.32601042
138SGK20.32311964
139CDK30.31356296
140MAP3K50.29974054
141PINK10.29008614

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.45233456
2Autoimmune thyroid disease_Homo sapiens_hsa053202.33219405
3Type I diabetes mellitus_Homo sapiens_hsa049402.32275505
4Antigen processing and presentation_Homo sapiens_hsa046122.10119220
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.04770096
6Staphylococcus aureus infection_Homo sapiens_hsa051501.98756623
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87860615
8Legionellosis_Homo sapiens_hsa051341.86141094
9Linoleic acid metabolism_Homo sapiens_hsa005911.75287814
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73807004
11Measles_Homo sapiens_hsa051621.70859974
12Hematopoietic cell lineage_Homo sapiens_hsa046401.68783153
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68284066
14Primary immunodeficiency_Homo sapiens_hsa053401.65786369
15Osteoclast differentiation_Homo sapiens_hsa043801.64904940
16Selenocompound metabolism_Homo sapiens_hsa004501.64780692
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64343201
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63558129
19Rheumatoid arthritis_Homo sapiens_hsa053231.58178918
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57974211
21Pertussis_Homo sapiens_hsa051331.54469414
22Ether lipid metabolism_Homo sapiens_hsa005651.48144350
23Caffeine metabolism_Homo sapiens_hsa002321.44898928
24Toxoplasmosis_Homo sapiens_hsa051451.43965965
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42055276
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41978378
27Graft-versus-host disease_Homo sapiens_hsa053321.41839186
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.37091268
29DNA replication_Homo sapiens_hsa030301.36448461
30Herpes simplex infection_Homo sapiens_hsa051681.36020380
31Protein export_Homo sapiens_hsa030601.32467121
32One carbon pool by folate_Homo sapiens_hsa006701.31676540
33Influenza A_Homo sapiens_hsa051641.28555705
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25860189
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.25174715
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.25108401
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24103780
38Tuberculosis_Homo sapiens_hsa051521.20431895
39Sphingolipid metabolism_Homo sapiens_hsa006001.19659451
40Lysosome_Homo sapiens_hsa041421.19207322
41Dorso-ventral axis formation_Homo sapiens_hsa043201.18949645
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.17690938
43TNF signaling pathway_Homo sapiens_hsa046681.16726740
44Apoptosis_Homo sapiens_hsa042101.14412942
45B cell receptor signaling pathway_Homo sapiens_hsa046621.14199531
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14142115
47Allograft rejection_Homo sapiens_hsa053301.13680014
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13173037
49Other glycan degradation_Homo sapiens_hsa005111.12951091
50Malaria_Homo sapiens_hsa051441.11277741
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09371664
52Folate biosynthesis_Homo sapiens_hsa007901.06091446
53Shigellosis_Homo sapiens_hsa051311.05627708
54Mismatch repair_Homo sapiens_hsa034301.04103078
55Hepatitis C_Homo sapiens_hsa051601.03216667
56Ribosome_Homo sapiens_hsa030101.02991987
57p53 signaling pathway_Homo sapiens_hsa041151.00976394
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00661171
59Arachidonic acid metabolism_Homo sapiens_hsa005900.99634603
60Complement and coagulation cascades_Homo sapiens_hsa046100.98328108
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97911037
62ABC transporters_Homo sapiens_hsa020100.96071480
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95873084
64Salmonella infection_Homo sapiens_hsa051320.94954577
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.92968385
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.91785970
67Thyroid cancer_Homo sapiens_hsa052160.91337168
68African trypanosomiasis_Homo sapiens_hsa051430.91206378
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87894851
70Hepatitis B_Homo sapiens_hsa051610.87650266
71Nitrogen metabolism_Homo sapiens_hsa009100.87518499
72Sulfur relay system_Homo sapiens_hsa041220.87083052
73Viral carcinogenesis_Homo sapiens_hsa052030.85927745
74Small cell lung cancer_Homo sapiens_hsa052220.85921095
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.82347702
76Histidine metabolism_Homo sapiens_hsa003400.82214769
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81634576
78Base excision repair_Homo sapiens_hsa034100.80579940
79Non-homologous end-joining_Homo sapiens_hsa034500.79122657
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78508726
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77510354
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77031573
83Basal transcription factors_Homo sapiens_hsa030220.74935709
84Epstein-Barr virus infection_Homo sapiens_hsa051690.73719715
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73307836
86Acute myeloid leukemia_Homo sapiens_hsa052210.73202582
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73016324
88T cell receptor signaling pathway_Homo sapiens_hsa046600.72979450
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72861133
90Asthma_Homo sapiens_hsa053100.71829660
91Mineral absorption_Homo sapiens_hsa049780.70496610
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68894909
93Circadian rhythm_Homo sapiens_hsa047100.68815077
94Chronic myeloid leukemia_Homo sapiens_hsa052200.68615716
95Platelet activation_Homo sapiens_hsa046110.68021154
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67994319
97Pentose phosphate pathway_Homo sapiens_hsa000300.67449949
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65899350
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.65788308
100Renin-angiotensin system_Homo sapiens_hsa046140.65577238
101Regulation of autophagy_Homo sapiens_hsa041400.64415552
102Sulfur metabolism_Homo sapiens_hsa009200.64249563
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63802641
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63155270
105Phagosome_Homo sapiens_hsa041450.62594716
106Collecting duct acid secretion_Homo sapiens_hsa049660.61817213
107Vitamin digestion and absorption_Homo sapiens_hsa049770.60233368
108Amoebiasis_Homo sapiens_hsa051460.60110307
109Nucleotide excision repair_Homo sapiens_hsa034200.59536568
110Chemical carcinogenesis_Homo sapiens_hsa052040.59251179
111Proteasome_Homo sapiens_hsa030500.58200509
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57989405
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57622826
114Systemic lupus erythematosus_Homo sapiens_hsa053220.56980473
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54638391
116Viral myocarditis_Homo sapiens_hsa054160.54579120
117HTLV-I infection_Homo sapiens_hsa051660.53900039
118Cell cycle_Homo sapiens_hsa041100.53767849
119Prolactin signaling pathway_Homo sapiens_hsa049170.52524884
120Pancreatic cancer_Homo sapiens_hsa052120.52405247
121Chemokine signaling pathway_Homo sapiens_hsa040620.52085541
122Galactose metabolism_Homo sapiens_hsa000520.52078621
123FoxO signaling pathway_Homo sapiens_hsa040680.49719927
124Fat digestion and absorption_Homo sapiens_hsa049750.47123673
125Inositol phosphate metabolism_Homo sapiens_hsa005620.43129375
126Retinol metabolism_Homo sapiens_hsa008300.42905099
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.42594046
128Glycerolipid metabolism_Homo sapiens_hsa005610.41027497
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.39133170
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.38547315
131Starch and sucrose metabolism_Homo sapiens_hsa005000.37864017
132Tryptophan metabolism_Homo sapiens_hsa003800.33632489
133RNA degradation_Homo sapiens_hsa030180.32572665

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