VPS45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.26605868
2synaptic vesicle exocytosis (GO:0016079)5.98820920
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.96117066
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54937543
5neurotransmitter-gated ion channel clustering (GO:0072578)5.34672388
6glutamate secretion (GO:0014047)5.19250603
7regulation of synaptic vesicle exocytosis (GO:2000300)5.18176546
8pyrimidine nucleobase catabolic process (GO:0006208)5.16037927
9vocalization behavior (GO:0071625)5.11977246
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02671163
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.96645026
12ATP hydrolysis coupled proton transport (GO:0015991)4.93968744
13energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.93968744
14synaptic vesicle maturation (GO:0016188)4.89209085
15protein localization to synapse (GO:0035418)4.84502201
16neuron cell-cell adhesion (GO:0007158)4.76852360
17positive regulation of synapse maturation (GO:0090129)4.70609381
18transferrin transport (GO:0033572)4.67183206
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.62850525
20regulation of synaptic vesicle transport (GO:1902803)4.61666136
21regulation of glutamate receptor signaling pathway (GO:1900449)4.60068549
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.59305831
23neurotransmitter secretion (GO:0007269)4.45302199
24trivalent inorganic cation transport (GO:0072512)4.33539919
25ferric iron transport (GO:0015682)4.33539919
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.12477558
27nucleobase catabolic process (GO:0046113)4.02341821
28neuron-neuron synaptic transmission (GO:0007270)4.00862746
29synaptic transmission, glutamatergic (GO:0035249)3.90704035
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.88845590
31locomotory exploration behavior (GO:0035641)3.88468461
32gamma-aminobutyric acid transport (GO:0015812)3.83984305
33positive regulation of mitochondrial fission (GO:0090141)3.80129436
34postsynaptic membrane organization (GO:0001941)3.76538234
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.72629685
36protein polyglutamylation (GO:0018095)3.70716170
37response to histamine (GO:0034776)3.66569156
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.66518577
39protein localization to cilium (GO:0061512)3.66255549
40amino acid salvage (GO:0043102)3.64458946
41L-methionine salvage (GO:0071267)3.64458946
42L-methionine biosynthetic process (GO:0071265)3.64458946
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64138420
44cullin deneddylation (GO:0010388)3.62610396
45long-term synaptic potentiation (GO:0060291)3.62547985
46synaptic vesicle endocytosis (GO:0048488)3.62504836
47phagosome maturation (GO:0090382)3.62190990
48glutamate receptor signaling pathway (GO:0007215)3.61168399
49regulation of synapse structural plasticity (GO:0051823)3.58243926
50proline transport (GO:0015824)3.56541632
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53268198
52exploration behavior (GO:0035640)3.52878517
53neurotransmitter transport (GO:0006836)3.50025363
54presynaptic membrane assembly (GO:0097105)3.48850900
55regulation of neuronal synaptic plasticity (GO:0048168)3.46775977
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46040345
57DNA damage response, detection of DNA damage (GO:0042769)3.45250409
58intraciliary transport (GO:0042073)3.43877270
59regulation of postsynaptic membrane potential (GO:0060078)3.41528827
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.41358447
61regulation of synapse maturation (GO:0090128)3.36161537
62positive regulation of neurotransmitter transport (GO:0051590)3.35327493
63positive regulation of neurotransmitter secretion (GO:0001956)3.34869372
64establishment of synaptic vesicle localization (GO:0097480)3.34506046
65synaptic vesicle transport (GO:0048489)3.34506046
66neuronal action potential propagation (GO:0019227)3.34393194
67female mating behavior (GO:0060180)3.32498623
68regulation of neurotransmitter secretion (GO:0046928)3.29281108
69regulation of female receptivity (GO:0045924)3.28997069
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.26976769
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26168951
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26168951
73regulation of neurotransmitter levels (GO:0001505)3.26104325
74serotonin metabolic process (GO:0042428)3.24096091
75startle response (GO:0001964)3.24051785
76innervation (GO:0060384)3.21339666
77regulation of vesicle fusion (GO:0031338)3.20780591
78regulation of synaptic plasticity (GO:0048167)3.19909328
79presynaptic membrane organization (GO:0097090)3.19861880
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19533358
81positive regulation of membrane potential (GO:0045838)3.18170470
82acrosome reaction (GO:0007340)3.17790341
83retinal ganglion cell axon guidance (GO:0031290)3.16532357
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14982166
85protein deneddylation (GO:0000338)3.14869903
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14717959
87long-term memory (GO:0007616)3.13889550
88negative regulation of microtubule polymerization (GO:0031115)3.13880719
89activation of protein kinase A activity (GO:0034199)3.13372422
90negative regulation of interleukin-17 production (GO:0032700)3.13080842
91DNA double-strand break processing (GO:0000729)3.08351648
92negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.06629979
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04937213
94cerebellar granule cell differentiation (GO:0021707)3.04367013
95regulation of cilium movement (GO:0003352)3.04201460
96positive regulation of synaptic transmission (GO:0050806)3.02721878
97preassembly of GPI anchor in ER membrane (GO:0016254)3.01153407
98regulation of neurotransmitter transport (GO:0051588)2.97499327
99C4-dicarboxylate transport (GO:0015740)2.94838341
100respiratory chain complex IV assembly (GO:0008535)2.91919809
101retinal cone cell development (GO:0046549)2.91606469
102NADH metabolic process (GO:0006734)2.90184141
103establishment of vesicle localization (GO:0051650)2.88715800
104cellular potassium ion homeostasis (GO:0030007)2.88687770
105synaptic transmission (GO:0007268)2.88273112
106behavioral fear response (GO:0001662)2.87654442
107behavioral defense response (GO:0002209)2.87654442
108synapse assembly (GO:0007416)2.86268062
109sequestering of actin monomers (GO:0042989)2.84561434
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.84204480
111cerebellar Purkinje cell differentiation (GO:0021702)2.84019378
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83251232
113water-soluble vitamin biosynthetic process (GO:0042364)2.83044126
114glycosphingolipid biosynthetic process (GO:0006688)2.83042895
115fear response (GO:0042596)2.81676796
116catecholamine transport (GO:0051937)2.81332396
117axonal fasciculation (GO:0007413)2.79965378
118nonmotile primary cilium assembly (GO:0035058)2.78495817
119regulation of synaptic transmission (GO:0050804)2.75267569
120protein-cofactor linkage (GO:0018065)2.74638130
121learning (GO:0007612)2.72787040
122positive regulation of synapse assembly (GO:0051965)2.72747580
123negative regulation of dendrite development (GO:2000171)2.72342962
124behavioral response to cocaine (GO:0048148)2.71472541
125long term synaptic depression (GO:0060292)2.71081605
126microtubule depolymerization (GO:0007019)2.70338769
127G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70313072
128membrane depolarization (GO:0051899)2.70262360
129mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70139579
130neuron recognition (GO:0008038)2.69314535
131regulation of voltage-gated calcium channel activity (GO:1901385)2.68843086
132mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.68740424
133proteasome assembly (GO:0043248)2.68371293
134organelle disassembly (GO:1903008)2.68066574
135intraspecies interaction between organisms (GO:0051703)2.67219224
136social behavior (GO:0035176)2.67219224
137layer formation in cerebral cortex (GO:0021819)2.67202218
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66990291
139mitochondrial respiratory chain complex I assembly (GO:0032981)2.66990291
140NADH dehydrogenase complex assembly (GO:0010257)2.66990291
141regulation of synaptic transmission, GABAergic (GO:0032228)2.63704926
142cilium organization (GO:0044782)2.63544441
143auditory behavior (GO:0031223)2.62143716
144cilium assembly (GO:0042384)2.61469103
145cilium morphogenesis (GO:0060271)2.58021448
146ribonucleoprotein complex disassembly (GO:0032988)2.55823380
147hippocampus development (GO:0021766)2.54520130
148positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53408317
149positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.52884284
150mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.52884284
151head development (GO:0060322)2.50743534
152hindbrain development (GO:0030902)2.49943794
153cellular ketone body metabolic process (GO:0046950)2.49643828
154calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46762872
155protein complex biogenesis (GO:0070271)2.45206212
156GPI anchor metabolic process (GO:0006505)2.44631975
157negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.42905330
158anterograde synaptic vesicle transport (GO:0048490)2.42658280
159axoneme assembly (GO:0035082)2.40819139
160regulation of microtubule-based movement (GO:0060632)2.38300318
161ubiquinone metabolic process (GO:0006743)2.38047999
162microtubule polymerization or depolymerization (GO:0031109)2.37847215
163methionine biosynthetic process (GO:0009086)2.36763539
164DNA integration (GO:0015074)2.36738322
165cell fate commitment involved in formation of primary germ layer (GO:0060795)2.36411915
166regulation of feeding behavior (GO:0060259)2.35725635
167epithelial cilium movement (GO:0003351)2.34801016
168protein K6-linked ubiquitination (GO:0085020)2.34738420
169RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.34588971
170response to nitrosative stress (GO:0051409)2.34533131
171dendritic spine morphogenesis (GO:0060997)2.34463515
172aldehyde catabolic process (GO:0046185)2.34279614
173cytochrome complex assembly (GO:0017004)2.28842290
174sperm motility (GO:0030317)2.27398543
175energy coupled proton transport, down electrochemical gradient (GO:0015985)2.26598126
176ATP synthesis coupled proton transport (GO:0015986)2.26598126
177positive regulation of dendritic spine morphogenesis (GO:0061003)2.25952803
178regulation of mitochondrial fission (GO:0090140)2.25927516
179ketone body metabolic process (GO:1902224)2.24926847
180regulation of cell communication by electrical coupling (GO:0010649)2.24122610
181substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.23434371
182substrate-independent telencephalic tangential migration (GO:0021826)2.23434371
183somatic hypermutation of immunoglobulin genes (GO:0016446)2.23267188
184somatic diversification of immune receptors via somatic mutation (GO:0002566)2.23267188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.30903501
2GBX2_23144817_ChIP-Seq_PC3_Human5.02935220
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.53893339
4REST_21632747_ChIP-Seq_MESCs_Mouse3.32655729
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14463609
6REST_18959480_ChIP-ChIP_MESCs_Mouse2.97393414
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89575092
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.78989759
9TAF15_26573619_Chip-Seq_HEK293_Human2.78887263
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.73293363
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70539934
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.70305226
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64009949
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57318102
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.48500815
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.40829378
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38890424
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38610625
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36581138
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32862481
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28780986
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28625805
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25040737
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21052201
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20600906
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16090032
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16090032
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13070480
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.06982397
30AR_21572438_ChIP-Seq_LNCaP_Human2.06930917
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.06409260
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02175141
33EWS_26573619_Chip-Seq_HEK293_Human1.99085890
34DROSHA_22980978_ChIP-Seq_HELA_Human1.94676925
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.93834185
36ZNF274_21170338_ChIP-Seq_K562_Hela1.88948999
37P300_19829295_ChIP-Seq_ESCs_Human1.87471535
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84928984
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84056923
40ELK1_19687146_ChIP-ChIP_HELA_Human1.81467717
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.77981606
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76678958
43* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74744486
44SMAD4_21799915_ChIP-Seq_A2780_Human1.73819827
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72414233
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.71137569
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.70312185
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.68122410
49AR_25329375_ChIP-Seq_VCAP_Human1.62497405
50FUS_26573619_Chip-Seq_HEK293_Human1.57175332
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56393197
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51111496
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49891491
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.49276149
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49261407
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48811164
57* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47643685
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46714374
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46105954
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43207102
61VDR_22108803_ChIP-Seq_LS180_Human1.39190730
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.34877020
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34508761
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34398638
65IRF1_19129219_ChIP-ChIP_H3396_Human1.30797201
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29163977
67TP53_22573176_ChIP-Seq_HFKS_Human1.28957882
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28486525
69* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28438207
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28355513
71IGF1R_20145208_ChIP-Seq_DFB_Human1.28288405
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28266273
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27726991
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.27073659
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26902334
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25561998
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.25309787
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22908924
79* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21891479
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21678357
81VDR_23849224_ChIP-Seq_CD4+_Human1.21621422
82* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21388533
83JUN_21703547_ChIP-Seq_K562_Human1.21035574
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20239755
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20143503
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.16006591
87* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16002719
88MYC_18940864_ChIP-ChIP_HL60_Human1.14908214
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14824784
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13599266
91* PRDM14_20953172_ChIP-Seq_ESCs_Human1.13104474
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.12664193
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11975641
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11762361
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10284264
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10038331
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08931196
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08323383
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07965906
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06703948
101BCAT_22108803_ChIP-Seq_LS180_Human1.06621118
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05627289
103CBP_20019798_ChIP-Seq_JUKART_Human1.05627289
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04665428
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04456159
106P53_22387025_ChIP-Seq_ESCs_Mouse1.04416445
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.04207316
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04089604
109* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03546933
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.02464163
111* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02196316
112RNF2_27304074_Chip-Seq_NSC_Mouse1.02010867
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01087884
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00471901
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99548735
116HTT_18923047_ChIP-ChIP_STHdh_Human0.99063112
117SRF_21415370_ChIP-Seq_HL-1_Mouse0.98332175
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.97570519
119RXR_22108803_ChIP-Seq_LS180_Human0.97213444
120CRX_20693478_ChIP-Seq_RETINA_Mouse0.96396513
121* ER_23166858_ChIP-Seq_MCF-7_Human0.96344209
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96037206
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.95516810
124SOX2_19829295_ChIP-Seq_ESCs_Human0.95095562
125NANOG_19829295_ChIP-Seq_ESCs_Human0.95095562
126* TCF4_22108803_ChIP-Seq_LS180_Human0.95041867
127SOX9_26525672_Chip-Seq_HEART_Mouse0.92832230
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.92664198
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89830787
130AR_19668381_ChIP-Seq_PC3_Human0.89783059
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89516907
132RUNX2_22187159_ChIP-Seq_PCA_Human0.87879453
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87444117
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.84283121
135TCF4_23295773_ChIP-Seq_U87_Human0.83419276
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.83412056
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81948297
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.81795498
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.81238863
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.80466407
141STAT3_23295773_ChIP-Seq_U87_Human0.80222187
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78199157
143AHR_22903824_ChIP-Seq_MCF-7_Human0.77113161
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.76542646
145TP53_18474530_ChIP-ChIP_U2OS_Human0.76499498
146FLI1_21867929_ChIP-Seq_TH2_Mouse0.76316746
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75737796
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75719728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.51203672
2MP0003880_abnormal_central_pattern4.88859833
3MP0003635_abnormal_synaptic_transmissio3.82115138
4MP0001968_abnormal_touch/_nociception3.40721655
5MP0009745_abnormal_behavioral_response3.25087702
6MP0002063_abnormal_learning/memory/cond3.20946568
7MP0002064_seizures3.13594421
8MP0004270_analgesia3.09992851
9MP0002736_abnormal_nociception_after3.06687670
10MP0009046_muscle_twitch3.02187880
11MP0002102_abnormal_ear_morphology2.84734902
12MP0003183_abnormal_peptide_metabolism2.79280395
13MP0002735_abnormal_chemical_nociception2.73625552
14MP0002572_abnormal_emotion/affect_behav2.72502579
15MP0010386_abnormal_urinary_bladder2.66182656
16MP0002272_abnormal_nervous_system2.47014552
17MP0002734_abnormal_mechanical_nocicepti2.46662380
18MP0009780_abnormal_chondrocyte_physiolo2.40343881
19MP0001501_abnormal_sleep_pattern2.24077991
20MP0001984_abnormal_olfaction2.19101853
21MP0005646_abnormal_pituitary_gland2.12184525
22MP0002733_abnormal_thermal_nociception2.09232294
23MP0002822_catalepsy2.08780510
24MP0003121_genomic_imprinting2.08037654
25MP0003879_abnormal_hair_cell2.03749168
26MP0006276_abnormal_autonomic_nervous1.98735087
27MP0001970_abnormal_pain_threshold1.98543481
28MP0004811_abnormal_neuron_physiology1.93512197
29MP0002909_abnormal_adrenal_gland1.93387733
30MP0002067_abnormal_sensory_capabilities1.92763852
31MP0001440_abnormal_grooming_behavior1.90078458
32MP0002184_abnormal_innervation1.81699576
33MP0003329_amyloid_beta_deposits1.80774166
34MP0001486_abnormal_startle_reflex1.78255808
35MP0002557_abnormal_social/conspecific_i1.69630023
36MP0005423_abnormal_somatic_nervous1.68185501
37MP0001905_abnormal_dopamine_level1.67072854
38MP0002876_abnormal_thyroid_physiology1.66612580
39MP0001529_abnormal_vocalization1.65902172
40MP0004885_abnormal_endolymph1.62952347
41MP0001188_hyperpigmentation1.61791011
42MP0002138_abnormal_hepatobiliary_system1.52179298
43MP0001502_abnormal_circadian_rhythm1.50449034
44MP0004858_abnormal_nervous_system1.45354604
45MP0005386_behavior/neurological_phenoty1.43642302
46MP0004924_abnormal_behavior1.43642302
47MP0008569_lethality_at_weaning1.42072676
48MP0003633_abnormal_nervous_system1.40196530
49MP0008995_early_reproductive_senescence1.40192064
50MP0000013_abnormal_adipose_tissue1.36536257
51MP0003172_abnormal_lysosome_physiology1.35949925
52MP0000778_abnormal_nervous_system1.34499261
53MP0002090_abnormal_vision1.33891131
54MP0010234_abnormal_vibrissa_follicle1.30797437
55MP0002653_abnormal_ependyma_morphology1.27963958
56MP0002882_abnormal_neuron_morphology1.27209532
57MP0003787_abnormal_imprinting1.24800912
58MP0005645_abnormal_hypothalamus_physiol1.23393054
59MP0003137_abnormal_impulse_conducting1.22922608
60MP0005499_abnormal_olfactory_system1.22704155
61MP0005394_taste/olfaction_phenotype1.22704155
62MP0002066_abnormal_motor_capabilities/c1.19575684
63MP0000427_abnormal_hair_cycle1.18431919
64MP0002638_abnormal_pupillary_reflex1.17910599
65MP0003011_delayed_dark_adaptation1.16509364
66MP0000604_amyloidosis1.15510027
67MP0005248_abnormal_Harderian_gland1.15333906
68MP0005551_abnormal_eye_electrophysiolog1.14575557
69MP0003631_nervous_system_phenotype1.10936751
70MP0000955_abnormal_spinal_cord1.09902573
71MP0000569_abnormal_digit_pigmentation1.06283706
72MP0003122_maternal_imprinting1.06030725
73MP0000516_abnormal_urinary_system1.04208738
74MP0005367_renal/urinary_system_phenotyp1.04208738
75MP0002234_abnormal_pharynx_morphology1.03884313
76MP0008872_abnormal_physiological_respon1.02218320
77MP0000647_abnormal_sebaceous_gland1.02168925
78MP0004145_abnormal_muscle_electrophysio1.01485477
79MP0008058_abnormal_DNA_repair1.01046591
80MP0005171_absent_coat_pigmentation1.00368800
81MP0005410_abnormal_fertilization0.97526048
82MP0002837_dystrophic_cardiac_calcinosis0.97200022
83MP0003221_abnormal_cardiomyocyte_apopto0.95848197
84MP0002229_neurodegeneration0.93705352
85MP0003385_abnormal_body_wall0.93350645
86MP0004084_abnormal_cardiac_muscle0.93223972
87MP0003646_muscle_fatigue0.92102227
88MP0001986_abnormal_taste_sensitivity0.91095275
89MP0004142_abnormal_muscle_tone0.90805569
90MP0003698_abnormal_male_reproductive0.89245296
91MP0000751_myopathy0.89095394
92MP0008789_abnormal_olfactory_epithelium0.88720498
93MP0000026_abnormal_inner_ear0.86633311
94MP0005409_darkened_coat_color0.84938238
95MP0005084_abnormal_gallbladder_morpholo0.83795681
96MP0002751_abnormal_autonomic_nervous0.83781271
97MP0001485_abnormal_pinna_reflex0.83350614
98MP0002152_abnormal_brain_morphology0.82544651
99MP0008775_abnormal_heart_ventricle0.82245856
100MP0005187_abnormal_penis_morphology0.81952302
101MP0004043_abnormal_pH_regulation0.81384581
102MP0002069_abnormal_eating/drinking_beha0.80779716
103MP0001177_atelectasis0.80347762
104MP0001929_abnormal_gametogenesis0.80187028
105MP0006072_abnormal_retinal_apoptosis0.79833352
106MP0000631_abnormal_neuroendocrine_gland0.79805453
107MP0000681_abnormal_thyroid_gland0.79481572
108MP0000639_abnormal_adrenal_gland0.78533365
109MP0001270_distended_abdomen0.77684177
110MP0004510_myositis0.75988191
111MP0000749_muscle_degeneration0.74813091
112MP0005195_abnormal_posterior_eye0.74352955
113MP0008260_abnormal_autophagy0.73909518
114MP0004147_increased_porphyrin_level0.72797057
115MP0003632_abnormal_nervous_system0.71389601
116MP0005379_endocrine/exocrine_gland_phen0.71144927
117MP0003075_altered_response_to0.70917983
118MP0005535_abnormal_body_temperature0.70916694
119MP0002132_abnormal_respiratory_system0.69779470
120MP0008874_decreased_physiological_sensi0.68619613
121MP0000015_abnormal_ear_pigmentation0.67335820
122MP0001963_abnormal_hearing_physiology0.67231466
123MP0006035_abnormal_mitochondrial_morpho0.64575276
124MP0001664_abnormal_digestion0.64109499
125MP0002752_abnormal_somatic_nervous0.62866377
126MP0002163_abnormal_gland_morphology0.60175170
127MP0004742_abnormal_vestibular_system0.59127666
128MP0004484_altered_response_of0.58861523
129MP0003634_abnormal_glial_cell0.56778468
130MP0005253_abnormal_eye_physiology0.54224982
131MP0008877_abnormal_DNA_methylation0.53998010
132MP0004085_abnormal_heartbeat0.51400365
133MP0005166_decreased_susceptibility_to0.49932324
134MP0004215_abnormal_myocardial_fiber0.47872310

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.13085361
2Epileptic encephalopathy (HP:0200134)5.43394156
3Atonic seizures (HP:0010819)5.12386586
4Absence seizures (HP:0002121)4.95305028
5Myokymia (HP:0002411)4.87753854
6Visual hallucinations (HP:0002367)4.78173914
7Focal seizures (HP:0007359)4.77283770
8Dialeptic seizures (HP:0011146)4.38184841
9Febrile seizures (HP:0002373)4.23928920
10Hyperventilation (HP:0002883)4.21678381
11Generalized tonic-clonic seizures (HP:0002069)3.58457488
12Abnormal eating behavior (HP:0100738)3.37569561
13Progressive cerebellar ataxia (HP:0002073)3.31032827
14Abnormal mitochondria in muscle tissue (HP:0008316)3.24025662
15Methylmalonic acidemia (HP:0002912)3.12311416
16Pheochromocytoma (HP:0002666)3.09009690
17Polyphagia (HP:0002591)3.07713697
18Retinal dysplasia (HP:0007973)3.05027079
19Acute necrotizing encephalopathy (HP:0006965)3.04776787
20Neuroendocrine neoplasm (HP:0100634)3.00534154
21Tubulointerstitial nephritis (HP:0001970)2.97811914
22Cortical dysplasia (HP:0002539)2.95726450
23Limb dystonia (HP:0002451)2.95013684
24Epileptiform EEG discharges (HP:0011182)2.92440582
25Poor suck (HP:0002033)2.91411964
26Hypothermia (HP:0002045)2.91186415
27Nephronophthisis (HP:0000090)2.88925361
28Protruding tongue (HP:0010808)2.84890012
293-Methylglutaconic aciduria (HP:0003535)2.83086797
30Truncal ataxia (HP:0002078)2.77792606
31Anxiety (HP:0000739)2.77510890
32Broad-based gait (HP:0002136)2.76514063
33Large eyes (HP:0001090)2.69366745
34Pachygyria (HP:0001302)2.69116556
35Depression (HP:0000716)2.69009503
36Agitation (HP:0000713)2.66856157
37Pancreatic cysts (HP:0001737)2.66771493
38EEG with generalized epileptiform discharges (HP:0011198)2.66615868
39Genital tract atresia (HP:0001827)2.62873659
40Progressive macrocephaly (HP:0004481)2.61111539
41Amblyopia (HP:0000646)2.59698635
42Renal cortical cysts (HP:0000803)2.59279443
43Mutism (HP:0002300)2.56731960
44Abnormal hair whorl (HP:0010721)2.52298201
45Fetal akinesia sequence (HP:0001989)2.51410975
46Abnormality of the renal medulla (HP:0100957)2.48390779
47Delusions (HP:0000746)2.47401955
48Vaginal atresia (HP:0000148)2.47121428
49Progressive inability to walk (HP:0002505)2.46410501
50Pancreatic fibrosis (HP:0100732)2.46031584
51Mitochondrial inheritance (HP:0001427)2.45734546
52Abnormality of the renal cortex (HP:0011035)2.43842632
53Abnormality of midbrain morphology (HP:0002418)2.42786242
54Molar tooth sign on MRI (HP:0002419)2.42786242
55Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.38384950
56Hypsarrhythmia (HP:0002521)2.37594670
57Drooling (HP:0002307)2.36152104
58Excessive salivation (HP:0003781)2.36152104
59Gait imbalance (HP:0002141)2.35579254
60Poor eye contact (HP:0000817)2.34674499
61Abnormality of macular pigmentation (HP:0008002)2.34081159
62Methylmalonic aciduria (HP:0012120)2.33268030
63Failure to thrive in infancy (HP:0001531)2.33127826
64Impaired vibration sensation in the lower limbs (HP:0002166)2.32510518
65Postaxial hand polydactyly (HP:0001162)2.32179420
66True hermaphroditism (HP:0010459)2.31639001
67Hemiparesis (HP:0001269)2.30619268
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.29948824
69Volvulus (HP:0002580)2.26884714
70Chronic hepatic failure (HP:0100626)2.26141770
71Spinal muscular atrophy (HP:0007269)2.26079967
72Postaxial foot polydactyly (HP:0001830)2.25939058
73Supranuclear gaze palsy (HP:0000605)2.22303937
74Cerebral hypomyelination (HP:0006808)2.20889594
75Papilledema (HP:0001085)2.19382760
76Hepatic necrosis (HP:0002605)2.19002686
77Inability to walk (HP:0002540)2.18939317
78Impaired smooth pursuit (HP:0007772)2.18777713
79Dysdiadochokinesis (HP:0002075)2.17617322
80Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17219625
81Hypoplasia of the brainstem (HP:0002365)2.17219625
82Abnormality of the anterior horn cell (HP:0006802)2.17208097
83Degeneration of anterior horn cells (HP:0002398)2.17208097
84Increased CSF lactate (HP:0002490)2.17037456
85Hypoventilation (HP:0002791)2.16175376
86Abnormal gallbladder physiology (HP:0012438)2.16021559
87Cholecystitis (HP:0001082)2.16021559
88Acute encephalopathy (HP:0006846)2.15314434
89Oligomenorrhea (HP:0000876)2.14378103
90Neoplasm of the peripheral nervous system (HP:0100007)2.14132209
91Microvesicular hepatic steatosis (HP:0001414)2.13316217
92Impaired social interactions (HP:0000735)2.11988417
93Abnormal social behavior (HP:0012433)2.11988417
94Urinary urgency (HP:0000012)2.11779070
95Action tremor (HP:0002345)2.11540786
96Abolished electroretinogram (ERG) (HP:0000550)2.11310982
97Spinal canal stenosis (HP:0003416)2.10854941
98Bradykinesia (HP:0002067)2.10133433
99Nephrogenic diabetes insipidus (HP:0009806)2.09361901
100Psychosis (HP:0000709)2.08020223
101Ulnar claw (HP:0001178)2.07563794
102Intestinal atresia (HP:0011100)2.06453351
103Gaze-evoked nystagmus (HP:0000640)2.06404817
104Mesomelia (HP:0003027)2.06358548
105Abnormality of the labia minora (HP:0012880)2.06316491
106Specific learning disability (HP:0001328)2.05389921
107Absent speech (HP:0001344)2.05227132
108Stereotypic behavior (HP:0000733)2.05192414
109Hepatocellular necrosis (HP:0001404)2.04069831
110Amyotrophic lateral sclerosis (HP:0007354)2.03949858
111Congenital primary aphakia (HP:0007707)2.02569709
112Abnormality of the lower motor neuron (HP:0002366)2.01783325
113Lipid accumulation in hepatocytes (HP:0006561)2.01262494
114Ankle clonus (HP:0011448)2.00791624
115Short tibia (HP:0005736)1.99919758
116Hypercortisolism (HP:0001578)1.98311513
117Median cleft lip (HP:0000161)1.98139137
118Increased serum lactate (HP:0002151)1.97138086
119Medial flaring of the eyebrow (HP:0010747)1.97093805
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.95998339
121Optic disc pallor (HP:0000543)1.95261648
122Focal dystonia (HP:0004373)1.95177271
123Tubulointerstitial abnormality (HP:0001969)1.94680212
124Intention tremor (HP:0002080)1.94616182
125Lissencephaly (HP:0001339)1.93333308
126Diplopia (HP:0000651)1.92968668
127Abnormality of binocular vision (HP:0011514)1.92968668
128Increased hepatocellular lipid droplets (HP:0006565)1.92172051
129Generalized myoclonic seizures (HP:0002123)1.88544071
130Hyperthyroidism (HP:0000836)1.86536817
131Urinary bladder sphincter dysfunction (HP:0002839)1.85997664
132Aplasia/hypoplasia of the uterus (HP:0008684)1.84295292
133Optic nerve hypoplasia (HP:0000609)1.84261056
134Abnormality of the astrocytes (HP:0100707)1.83992818
135Astrocytoma (HP:0009592)1.83992818
136Renal hypoplasia (HP:0000089)1.83769931
137Unsteady gait (HP:0002317)1.83529245
138Congenital hepatic fibrosis (HP:0002612)1.83351296
139Wrist flexion contracture (HP:0001239)1.83199312
140Impaired pain sensation (HP:0007328)1.83045237
141Abnormality of pain sensation (HP:0010832)1.83045237
142Torticollis (HP:0000473)1.81978600
143Sleep apnea (HP:0010535)1.81918807
144Resting tremor (HP:0002322)1.81816414
145Rimmed vacuoles (HP:0003805)1.81372638
146Menstrual irregularities (HP:0000858)1.81029026
147Muscular hypotonia of the trunk (HP:0008936)1.80509534
148Status epilepticus (HP:0002133)1.79242507
149Progressive microcephaly (HP:0000253)1.78442765
150Akinesia (HP:0002304)1.78406771
151Astigmatism (HP:0000483)1.76973645
152Poor coordination (HP:0002370)1.76938384
153CNS demyelination (HP:0007305)1.76485831
154Rigidity (HP:0002063)1.76402608
155Degeneration of the lateral corticospinal tracts (HP:0002314)1.75520917
156Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75520917
157Abnormality of the vitamin B12 metabolism (HP:0004341)1.75326627
158Abnormality of ocular smooth pursuit (HP:0000617)1.74411841
159Emotional lability (HP:0000712)1.74181466
160Abnormality of glycolysis (HP:0004366)1.74069032
161Increased serum pyruvate (HP:0003542)1.74069032
162Growth hormone excess (HP:0000845)1.73716510
163Dysmetric saccades (HP:0000641)1.73518100
164Glioma (HP:0009733)1.71150727
165Abnormality of vitamin B metabolism (HP:0004340)1.70301238
166Abnormality of the vocal cords (HP:0008777)1.70191945
167CNS hypomyelination (HP:0003429)1.70172270
168Spastic tetraplegia (HP:0002510)1.69752096
169Tongue fasciculations (HP:0001308)1.69303343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.66618088
2BMPR1B4.38803694
3NTRK34.15493171
4MAP3K43.74773652
5MAP3K123.68321783
6MAP2K73.44184097
7MAP4K23.35772371
8TRIM283.12788501
9EPHA43.01445830
10MAP3K92.82449247
11CDK192.70157451
12MARK12.68233446
13MINK12.67132974
14DAPK12.53085702
15CDK82.36218726
16MAP2K42.20450701
17DAPK22.13887088
18PLK22.06665453
19PRPF4B1.91124438
20TGFBR11.91118180
21CAMKK21.90977122
22STK161.78047114
23TNIK1.70489935
24CSNK1G31.66983313
25NME11.65057998
26CSNK1A1L1.59298580
27CCNB11.56477296
28ARAF1.55953469
29DYRK21.51485438
30SCYL21.51092499
31CAMKK11.50630346
32FES1.48369910
33SIK31.44750336
34RIPK41.42219343
35CSNK1G11.40885694
36SRPK11.40016400
37ZAK1.39136113
38GRK51.37633512
39KSR11.31069693
40PRKCG1.30752737
41GRK11.25810448
42RPS6KA41.23216684
43PAK61.23028299
44CDK51.22802979
45TSSK61.20619191
46INSRR1.20450082
47BCKDK1.20334166
48PLK41.17157192
49EPHA31.16555665
50KSR21.11828902
51MAP3K21.08023893
52MAP3K131.06716953
53MAPK131.04539839
54ADRBK21.03242974
55LIMK11.02100347
56NTRK21.01744750
57STK38L1.00575597
58NEK10.98571454
59CDK180.98411473
60EIF2AK10.95064101
61CDK140.94287298
62SGK2230.93922998
63SGK4940.93922998
64STK380.89336126
65NTRK10.88967235
66CDK150.88966439
67SGK20.88685327
68NUAK10.87404964
69EIF2AK30.84837683
70CAMK2A0.83628686
71PLK30.82814535
72SYK0.82772441
73VRK10.81206658
74PTK2B0.79207254
75VRK20.77898144
76CDK11A0.77563391
77DYRK1B0.76504799
78TESK10.75686526
79CDK90.75232517
80SIK20.75108392
81DYRK30.73460267
82BRAF0.70665862
83FER0.69495222
84PRKCE0.67608839
85MAP2K10.67213623
86PIM20.66620919
87BRSK10.66479110
88DYRK1A0.66355761
89CAMK2B0.63858644
90PKN10.63314575
91RET0.63098238
92CAMK10.62636366
93SGK30.60879494
94PDK40.59195664
95PDK30.59195664
96LMTK20.58051213
97CAMK2G0.57897295
98ATR0.56914135
99PHKG20.56448405
100PHKG10.56448405
101UHMK10.56114881
102CSNK1A10.54431326
103OBSCN0.54000048
104PINK10.53257374
105ADRBK10.52312770
106FRK0.51929396
107PRKACB0.51700481
108TAF10.51281998
109CDK30.51194902
110GRK70.49873169
111CAMK40.49709939
112DAPK30.49121969
113TAOK10.48607265
114PDK20.46780979
115MST40.46674112
116MAP3K50.45878609
117MAPK120.45528253
118PRKCH0.44880910
119MET0.42705881
120SGK10.42071030
121GRK60.40675357
122MUSK0.40666203
123PLK10.38957635
124MOS0.38877430
125OXSR10.36077058
126TAOK20.35877356
127MAPKAPK50.35732338
128PRKCZ0.35494255
129PRKD30.35410258
130PRKACA0.34829162
131MKNK20.34163145
132RAF10.34120375
133ERBB30.33927334
134CSNK1G20.33002562
135RPS6KA50.32550776
136ATM0.32413974
137PAK30.31627180
138CAMK2D0.31201931
139CSNK1E0.31193260
140AKT30.27954263
141BCR0.27863946
142MAP3K60.27113781
143PRKCA0.26790695
144BUB10.26726186
145FYN0.25724402
146PBK0.25265283
147WNK30.23464589
148MAPK70.22797197

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.69967229
2Collecting duct acid secretion_Homo sapiens_hsa049663.87387950
3Nicotine addiction_Homo sapiens_hsa050333.77540352
4Olfactory transduction_Homo sapiens_hsa047402.71234996
5Vibrio cholerae infection_Homo sapiens_hsa051102.70324833
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57123047
7Circadian entrainment_Homo sapiens_hsa047132.45095876
8Protein export_Homo sapiens_hsa030602.44752085
9GABAergic synapse_Homo sapiens_hsa047272.43127917
10Amphetamine addiction_Homo sapiens_hsa050312.31581322
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28948769
12Long-term potentiation_Homo sapiens_hsa047202.24791212
13Morphine addiction_Homo sapiens_hsa050322.23250186
14Dopaminergic synapse_Homo sapiens_hsa047282.12362719
15Butanoate metabolism_Homo sapiens_hsa006502.11219211
16Propanoate metabolism_Homo sapiens_hsa006402.09815363
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05659662
18Oxidative phosphorylation_Homo sapiens_hsa001902.01686919
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98852598
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92896321
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88457282
22Glutamatergic synapse_Homo sapiens_hsa047241.88367623
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.84212395
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83287008
25Insulin secretion_Homo sapiens_hsa049111.83104327
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59585994
27Salivary secretion_Homo sapiens_hsa049701.59080851
28Cocaine addiction_Homo sapiens_hsa050301.53947177
29Renin secretion_Homo sapiens_hsa049241.51893594
30Taste transduction_Homo sapiens_hsa047421.51643545
31Cholinergic synapse_Homo sapiens_hsa047251.50912647
32Proteasome_Homo sapiens_hsa030501.50714797
33Serotonergic synapse_Homo sapiens_hsa047261.49772067
34Parkinsons disease_Homo sapiens_hsa050121.47534839
35Fatty acid elongation_Homo sapiens_hsa000621.45463424
36Rheumatoid arthritis_Homo sapiens_hsa053231.43859131
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43110603
38Gastric acid secretion_Homo sapiens_hsa049711.39853567
39Fanconi anemia pathway_Homo sapiens_hsa034601.38594398
40Basal transcription factors_Homo sapiens_hsa030221.37570976
41Alzheimers disease_Homo sapiens_hsa050101.34141881
42Long-term depression_Homo sapiens_hsa047301.27063505
43Non-homologous end-joining_Homo sapiens_hsa034501.26424583
44Oxytocin signaling pathway_Homo sapiens_hsa049211.26376025
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24798318
46Steroid biosynthesis_Homo sapiens_hsa001001.24703528
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23861591
48Phagosome_Homo sapiens_hsa041451.20158178
49Calcium signaling pathway_Homo sapiens_hsa040201.20066461
50Peroxisome_Homo sapiens_hsa041461.14597411
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13727744
52RNA polymerase_Homo sapiens_hsa030201.11019415
53beta-Alanine metabolism_Homo sapiens_hsa004101.09719787
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05949578
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05473045
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03991048
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02905419
58Phototransduction_Homo sapiens_hsa047441.02571279
59Type I diabetes mellitus_Homo sapiens_hsa049400.98741840
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.98222055
61RNA degradation_Homo sapiens_hsa030180.97229520
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.96354052
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95822532
64Gap junction_Homo sapiens_hsa045400.95455682
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94896912
66GnRH signaling pathway_Homo sapiens_hsa049120.92387749
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92218779
68Nitrogen metabolism_Homo sapiens_hsa009100.92053110
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91147863
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89769272
71Glioma_Homo sapiens_hsa052140.88031785
72Circadian rhythm_Homo sapiens_hsa047100.87177592
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87026483
74Huntingtons disease_Homo sapiens_hsa050160.86862896
75Type II diabetes mellitus_Homo sapiens_hsa049300.86481596
76Fatty acid metabolism_Homo sapiens_hsa012120.85807126
77Tryptophan metabolism_Homo sapiens_hsa003800.85480444
78RNA transport_Homo sapiens_hsa030130.83471619
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81369709
80Estrogen signaling pathway_Homo sapiens_hsa049150.78509778
81Mismatch repair_Homo sapiens_hsa034300.77664451
82Caffeine metabolism_Homo sapiens_hsa002320.77254766
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76856093
84cAMP signaling pathway_Homo sapiens_hsa040240.76142360
85Cardiac muscle contraction_Homo sapiens_hsa042600.75354076
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75102636
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74467160
88Alcoholism_Homo sapiens_hsa050340.74132797
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73490623
90Ether lipid metabolism_Homo sapiens_hsa005650.73181111
91ErbB signaling pathway_Homo sapiens_hsa040120.70397270
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70288545
93Fatty acid degradation_Homo sapiens_hsa000710.69974182
94Regulation of autophagy_Homo sapiens_hsa041400.69157729
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68196569
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67989891
97Oocyte meiosis_Homo sapiens_hsa041140.65884399
98Homologous recombination_Homo sapiens_hsa034400.65711237
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65133233
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62818359
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61642020
102Linoleic acid metabolism_Homo sapiens_hsa005910.60500690
103Selenocompound metabolism_Homo sapiens_hsa004500.60326458
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59749436
105Metabolic pathways_Homo sapiens_hsa011000.56843474
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.54120439
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52205197
108Purine metabolism_Homo sapiens_hsa002300.49601136
109Biosynthesis of amino acids_Homo sapiens_hsa012300.49219199
110Tuberculosis_Homo sapiens_hsa051520.48988525
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48658579
112Lysosome_Homo sapiens_hsa041420.47921098
113Pyruvate metabolism_Homo sapiens_hsa006200.47029613
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46693903
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46482044
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45942991
117Melanogenesis_Homo sapiens_hsa049160.45616786
118Fructose and mannose metabolism_Homo sapiens_hsa000510.45317845
119Hedgehog signaling pathway_Homo sapiens_hsa043400.44154652
120Base excision repair_Homo sapiens_hsa034100.44002847
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43737835
122Glucagon signaling pathway_Homo sapiens_hsa049220.43646041
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43110419
124Spliceosome_Homo sapiens_hsa030400.42536645
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42354603
126Axon guidance_Homo sapiens_hsa043600.41639541
127Dorso-ventral axis formation_Homo sapiens_hsa043200.39134111
128Colorectal cancer_Homo sapiens_hsa052100.36599140
129MAPK signaling pathway_Homo sapiens_hsa040100.35932109
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.35587964
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35527232
132Nucleotide excision repair_Homo sapiens_hsa034200.34396414
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33775528
134Thyroid hormone synthesis_Homo sapiens_hsa049180.33627970
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33529791
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.33212510
137Folate biosynthesis_Homo sapiens_hsa007900.32133853
138Pertussis_Homo sapiens_hsa051330.31657095
139Insulin signaling pathway_Homo sapiens_hsa049100.30351882
140N-Glycan biosynthesis_Homo sapiens_hsa005100.29226435
141African trypanosomiasis_Homo sapiens_hsa051430.29182558
142Prolactin signaling pathway_Homo sapiens_hsa049170.27716638
143* Endocytosis_Homo sapiens_hsa041440.27003179
144Ras signaling pathway_Homo sapiens_hsa040140.26732646
145Prion diseases_Homo sapiens_hsa050200.24829059
146Pancreatic secretion_Homo sapiens_hsa049720.24407338
147Carbon metabolism_Homo sapiens_hsa012000.24014718
148Shigellosis_Homo sapiens_hsa051310.23093683
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.22985380
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.22564253
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22560561
152VEGF signaling pathway_Homo sapiens_hsa043700.20891510

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