VPS41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.73925834
2glutamate secretion (GO:0014047)5.39159680
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.29765852
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.24717187
5regulation of synaptic vesicle exocytosis (GO:2000300)5.24177959
6synaptic vesicle maturation (GO:0016188)5.16076509
7vocalization behavior (GO:0071625)4.95232605
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70273918
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.63127877
10neurotransmitter-gated ion channel clustering (GO:0072578)4.62706185
11neurotransmitter secretion (GO:0007269)4.54617907
12regulation of synaptic vesicle transport (GO:1902803)4.54524780
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.47912637
14regulation of glutamate receptor signaling pathway (GO:1900449)4.45785915
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.39634969
16neuronal action potential propagation (GO:0019227)4.38883760
17neuron cell-cell adhesion (GO:0007158)4.38530289
18protein localization to synapse (GO:0035418)4.28602252
19locomotory exploration behavior (GO:0035641)4.22774324
20pyrimidine nucleobase catabolic process (GO:0006208)4.16879072
21proline transport (GO:0015824)4.12502712
22regulation of synapse structural plasticity (GO:0051823)3.91631644
23neuron-neuron synaptic transmission (GO:0007270)3.80547048
24regulation of neuronal synaptic plasticity (GO:0048168)3.74702728
25nucleobase catabolic process (GO:0046113)3.70755426
26presynaptic membrane assembly (GO:0097105)3.70206737
27protein localization to cilium (GO:0061512)3.69375536
28gamma-aminobutyric acid transport (GO:0015812)3.68934975
29neurotransmitter transport (GO:0006836)3.65098211
30synaptic transmission, glutamatergic (GO:0035249)3.64724893
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.62156655
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.60750826
33energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.58085547
34ATP hydrolysis coupled proton transport (GO:0015991)3.58085547
35exploration behavior (GO:0035640)3.56295185
36transferrin transport (GO:0033572)3.56095678
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52731553
38long-term synaptic potentiation (GO:0060291)3.50937569
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.49553381
40negative regulation of dendrite morphogenesis (GO:0050774)3.45071054
41presynaptic membrane organization (GO:0097090)3.45013474
42neuromuscular process controlling posture (GO:0050884)3.42308800
43regulation of neurotransmitter secretion (GO:0046928)3.39951257
44regulation of neurotransmitter levels (GO:0001505)3.39064950
45glutamate receptor signaling pathway (GO:0007215)3.36295317
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.35207980
47ferric iron transport (GO:0015682)3.34925071
48trivalent inorganic cation transport (GO:0072512)3.34925071
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.32047563
50positive regulation of membrane potential (GO:0045838)3.28525180
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27753677
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27509729
53postsynaptic membrane organization (GO:0001941)3.27121083
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25911154
55layer formation in cerebral cortex (GO:0021819)3.23899347
56activation of protein kinase A activity (GO:0034199)3.23459292
57regulation of synaptic plasticity (GO:0048167)3.22034463
58brain morphogenesis (GO:0048854)3.20412263
59synaptic vesicle endocytosis (GO:0048488)3.19773260
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18392669
61regulation of neurotransmitter transport (GO:0051588)3.18137405
62positive regulation of synapse maturation (GO:0090129)3.14112555
63regulation of postsynaptic membrane potential (GO:0060078)3.12300973
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09910755
65vesicle transport along microtubule (GO:0047496)3.09363628
66neuron recognition (GO:0008038)3.07490716
67negative regulation of dendrite development (GO:2000171)3.07384482
68cerebellar Purkinje cell differentiation (GO:0021702)3.06146280
69positive regulation of neurotransmitter transport (GO:0051590)3.05327666
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05082829
71response to histamine (GO:0034776)3.03477995
72synapse assembly (GO:0007416)3.02461518
73auditory behavior (GO:0031223)2.97246635
74transmission of nerve impulse (GO:0019226)2.96483632
75striatum development (GO:0021756)2.95883479
76response to auditory stimulus (GO:0010996)2.95853624
77regulation of vesicle fusion (GO:0031338)2.95771809
78righting reflex (GO:0060013)2.94992217
79innervation (GO:0060384)2.92996320
80positive regulation of synaptic transmission (GO:0050806)2.92038029
81cerebellar granule cell differentiation (GO:0021707)2.92018481
82establishment of synaptic vesicle localization (GO:0097480)2.91549177
83synaptic vesicle transport (GO:0048489)2.91549177
84positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91464076
85synaptic transmission (GO:0007268)2.89198489
86macroautophagy (GO:0016236)2.87413923
87organelle transport along microtubule (GO:0072384)2.87225567
88behavioral response to cocaine (GO:0048148)2.85603047
89regulation of synaptic transmission (GO:0050804)2.85092486
90neuromuscular process controlling balance (GO:0050885)2.84810682
91regulation of protein glycosylation (GO:0060049)2.84668953
92establishment of vesicle localization (GO:0051650)2.84544407
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83557614
94regulation of cilium movement (GO:0003352)2.82173041
95regulation of glutamate secretion (GO:0014048)2.81929433
96calcium ion-dependent exocytosis (GO:0017156)2.79837411
97positive regulation of neurotransmitter secretion (GO:0001956)2.78530195
98neuromuscular process (GO:0050905)2.77755059
99vascular smooth muscle contraction (GO:0014829)2.76740912
100cellular potassium ion homeostasis (GO:0030007)2.76536725
101reflex (GO:0060004)2.76019353
102axonal fasciculation (GO:0007413)2.75862256
103membrane hyperpolarization (GO:0060081)2.75358956
104membrane depolarization (GO:0051899)2.75285624
105membrane depolarization during action potential (GO:0086010)2.75082923
106dendritic spine morphogenesis (GO:0060997)2.74262232
107acidic amino acid transport (GO:0015800)2.73862842
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73301697
109nonmotile primary cilium assembly (GO:0035058)2.72857826
110regulation of dendritic spine morphogenesis (GO:0061001)2.72658248
111prostate gland growth (GO:0060736)2.72453736
112regulation of female receptivity (GO:0045924)2.72370675
113long-term memory (GO:0007616)2.71851499
114detection of calcium ion (GO:0005513)2.71149370
115positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.70922200
116synapse organization (GO:0050808)2.70491853
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68585252
118regulation of clathrin-mediated endocytosis (GO:2000369)2.61314813
119platelet dense granule organization (GO:0060155)2.59054491
120melanosome transport (GO:0032402)2.57506678
121cellular response to leptin stimulus (GO:0044320)2.57104883
122glycosphingolipid biosynthetic process (GO:0006688)2.53560555
123pigment granule transport (GO:0051904)2.53118121
124establishment of melanosome localization (GO:0032401)2.52865345
125cilium morphogenesis (GO:0060271)2.52661562
126establishment of nucleus localization (GO:0040023)2.52109789
127intraciliary transport (GO:0042073)2.49310028
128establishment of pigment granule localization (GO:0051905)2.48869391
129myelin assembly (GO:0032288)2.48080393
130dendrite morphogenesis (GO:0048813)2.45114861
131C4-dicarboxylate transport (GO:0015740)2.43501987
132early endosome to late endosome transport (GO:0045022)2.41610785
133inositol phosphate catabolic process (GO:0071545)2.40031237
134insulin secretion (GO:0030073)2.39658434
135positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.39319926
136nerve growth factor signaling pathway (GO:0038180)2.37889098
137regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.36325346
138calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.35699237
139clathrin coat assembly (GO:0048268)2.35374659
140negative regulation of neurotransmitter transport (GO:0051589)2.32998029
141retinal ganglion cell axon guidance (GO:0031290)2.32795999
142response to lipoprotein particle (GO:0055094)2.32596787
143startle response (GO:0001964)2.32418354
144neurotransmitter uptake (GO:0001504)2.31596573
145regulation of beta-amyloid formation (GO:1902003)2.31173442
146intra-Golgi vesicle-mediated transport (GO:0006891)2.31074064
147neuronal ion channel clustering (GO:0045161)2.30419332
148response to pheromone (GO:0019236)2.30016566
149cilium assembly (GO:0042384)2.27895262
150regulation of neurotransmitter uptake (GO:0051580)2.26644542
151cellular ketone body metabolic process (GO:0046950)2.26594910
152protein targeting to vacuole (GO:0006623)2.25223162
153protein targeting to lysosome (GO:0006622)2.25223162
154establishment of protein localization to vacuole (GO:0072666)2.25223162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67022541
2GBX2_23144817_ChIP-Seq_PC3_Human4.49446302
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99332839
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82567608
5REST_21632747_ChIP-Seq_MESCs_Mouse2.69033606
6TAF15_26573619_Chip-Seq_HEK293_Human2.57688517
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56809613
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45074478
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42519013
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41349564
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.35810141
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29949700
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29664708
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.29234213
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27943368
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25575941
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25021334
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25021334
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20344632
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18352526
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.06960123
22DROSHA_22980978_ChIP-Seq_HELA_Human2.01682697
23SMAD4_21799915_ChIP-Seq_A2780_Human1.99138989
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.98379749
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98229269
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91135505
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.89568746
28P300_19829295_ChIP-Seq_ESCs_Human1.85861855
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85381572
30AR_21572438_ChIP-Seq_LNCaP_Human1.85212654
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81196079
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77306303
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76628079
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70546643
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68323267
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.66634344
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66111968
38IGF1R_20145208_ChIP-Seq_DFB_Human1.66032795
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.64833424
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64067929
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63647511
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62551364
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60030526
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.58044046
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.57693303
46EWS_26573619_Chip-Seq_HEK293_Human1.57593184
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57192103
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55876061
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55467905
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52579815
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51462778
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51410549
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51091363
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.50947904
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49648275
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.49454333
57ZNF274_21170338_ChIP-Seq_K562_Hela1.49450947
58P53_22387025_ChIP-Seq_ESCs_Mouse1.49221998
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49132460
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49044081
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46978099
62AR_25329375_ChIP-Seq_VCAP_Human1.46202792
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.44436006
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.44278985
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44111761
66* STAT3_23295773_ChIP-Seq_U87_Human1.42152686
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.38344030
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.38217998
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.36659246
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34922422
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30433858
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29620701
73* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28523549
74FUS_26573619_Chip-Seq_HEK293_Human1.27982041
75TP53_16413492_ChIP-PET_HCT116_Human1.27527737
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25890761
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.25509831
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.24704089
79ER_23166858_ChIP-Seq_MCF-7_Human1.23611748
80JUN_21703547_ChIP-Seq_K562_Human1.23365109
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22140225
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21439691
83P300_18555785_Chip-Seq_ESCs_Mouse1.20920056
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20727507
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.19872576
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19529859
87* TCF4_23295773_ChIP-Seq_U87_Human1.18778885
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17481372
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.17373184
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.16734511
91* AR_19668381_ChIP-Seq_PC3_Human1.15171908
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14910702
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14326227
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14326227
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.13672712
96* FLI1_21867929_ChIP-Seq_TH2_Mouse1.13087292
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12259080
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.11846677
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11723478
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.11702261
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11127756
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.10990869
103VDR_22108803_ChIP-Seq_LS180_Human1.10941615
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10559144
105* TP53_18474530_ChIP-ChIP_U2OS_Human1.10434850
106RUNX2_22187159_ChIP-Seq_PCA_Human1.10136195
107BCAT_22108803_ChIP-Seq_LS180_Human1.09150867
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09138195
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08224775
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07146597
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07146597
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07022772
113AHR_22903824_ChIP-Seq_MCF-7_Human1.06929358
114RNF2_27304074_Chip-Seq_NSC_Mouse1.06363320
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05093775
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.04305921
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.03906772
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03567344
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03221284
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02837362
121KDM2B_26808549_Chip-Seq_REH_Human1.02343399
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00836857
123CBX2_27304074_Chip-Seq_ESCs_Mouse1.00324783
124TCF4_22108803_ChIP-Seq_LS180_Human0.99707072
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98334294
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.97959285
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97335768
128* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96882990
129* CBP_20019798_ChIP-Seq_JUKART_Human0.96882990
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96619268
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95341151
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.95174842
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94636141
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.94635147
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94049272
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94048015
137RXR_22108803_ChIP-Seq_LS180_Human0.93677967
138CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93614527
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93198224
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91939258
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91559167
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.91533304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.51575487
2MP0003880_abnormal_central_pattern4.69299824
3MP0003635_abnormal_synaptic_transmissio3.82509885
4MP0004270_analgesia3.58594562
5MP0001968_abnormal_touch/_nociception3.34388151
6MP0009046_muscle_twitch3.30565754
7MP0002064_seizures3.25095517
8MP0009745_abnormal_behavioral_response3.22682807
9MP0002063_abnormal_learning/memory/cond3.12284622
10MP0002736_abnormal_nociception_after2.89580271
11MP0002734_abnormal_mechanical_nocicepti2.74009807
12MP0002572_abnormal_emotion/affect_behav2.69611231
13MP0002272_abnormal_nervous_system2.59360733
14MP0009780_abnormal_chondrocyte_physiolo2.59136208
15MP0005248_abnormal_Harderian_gland2.57264009
16MP0002822_catalepsy2.50965745
17MP0002735_abnormal_chemical_nociception2.45978143
18MP0002102_abnormal_ear_morphology2.38860476
19MP0003329_amyloid_beta_deposits2.23749121
20MP0002733_abnormal_thermal_nociception2.22732132
21MP0001486_abnormal_startle_reflex2.19046047
22MP0001501_abnormal_sleep_pattern2.14927189
23MP0001440_abnormal_grooming_behavior2.13848341
24MP0001970_abnormal_pain_threshold2.03385400
25MP0002067_abnormal_sensory_capabilities1.96394612
26MP0006276_abnormal_autonomic_nervous1.92515827
27MP0004858_abnormal_nervous_system1.92414322
28MP0005646_abnormal_pituitary_gland1.92362006
29MP0008877_abnormal_DNA_methylation1.85520837
30MP0003122_maternal_imprinting1.82383584
31MP0005253_abnormal_eye_physiology1.79433474
32MP0006072_abnormal_retinal_apoptosis1.75782011
33MP0002909_abnormal_adrenal_gland1.72947550
34MP0001984_abnormal_olfaction1.70788724
35MP0005386_behavior/neurological_phenoty1.70579513
36MP0004924_abnormal_behavior1.70579513
37MP0003787_abnormal_imprinting1.70243093
38MP0002184_abnormal_innervation1.68177557
39MP0004811_abnormal_neuron_physiology1.67876325
40MP0001529_abnormal_vocalization1.64396937
41MP0003879_abnormal_hair_cell1.63192286
42MP0000427_abnormal_hair_cycle1.60773063
43MP0005423_abnormal_somatic_nervous1.60639396
44MP0000778_abnormal_nervous_system1.57534985
45MP0000013_abnormal_adipose_tissue1.55620877
46MP0002876_abnormal_thyroid_physiology1.55519435
47MP0002557_abnormal_social/conspecific_i1.54990549
48MP0008569_lethality_at_weaning1.54214392
49MP0002837_dystrophic_cardiac_calcinosis1.53505911
50MP0003633_abnormal_nervous_system1.47601395
51MP0000955_abnormal_spinal_cord1.45939008
52MP0004142_abnormal_muscle_tone1.45397971
53MP0002066_abnormal_motor_capabilities/c1.38020637
54MP0000604_amyloidosis1.34906946
55MP0005379_endocrine/exocrine_gland_phen1.32784386
56MP0005174_abnormal_tail_pigmentation1.31377911
57MP0001905_abnormal_dopamine_level1.30882547
58MP0002882_abnormal_neuron_morphology1.28139235
59MP0006054_spinal_hemorrhage1.27503737
60MP0003631_nervous_system_phenotype1.24649656
61MP0005645_abnormal_hypothalamus_physiol1.20921759
62MP0000372_irregular_coat_pigmentation1.20782796
63MP0003690_abnormal_glial_cell1.17318582
64MP0010386_abnormal_urinary_bladder1.15678134
65MP0000569_abnormal_digit_pigmentation1.15500867
66MP0001502_abnormal_circadian_rhythm1.11265261
67MP0005187_abnormal_penis_morphology1.10475961
68MP0005408_hypopigmentation1.07947817
69MP0004885_abnormal_endolymph1.07920394
70MP0002229_neurodegeneration1.07510082
71MP0000647_abnormal_sebaceous_gland1.06684770
72MP0003011_delayed_dark_adaptation1.05974131
73MP0002928_abnormal_bile_duct1.02777823
74MP0003183_abnormal_peptide_metabolism1.01889630
75MP0003634_abnormal_glial_cell1.00344066
76MP0000751_myopathy1.00083604
77MP0002938_white_spotting0.99525031
78MP0001756_abnormal_urination0.99350351
79MP0010678_abnormal_skin_adnexa0.99063128
80MP0003632_abnormal_nervous_system0.97008927
81MP0000516_abnormal_urinary_system0.96531865
82MP0005367_renal/urinary_system_phenotyp0.96531865
83MP0002095_abnormal_skin_pigmentation0.96178025
84MP0008872_abnormal_physiological_respon0.94728666
85MP0001177_atelectasis0.94523556
86MP0002069_abnormal_eating/drinking_beha0.94142711
87MP0002090_abnormal_vision0.93969666
88MP0002295_abnormal_pulmonary_circulatio0.91720964
89MP0001188_hyperpigmentation0.91572687
90MP0002751_abnormal_autonomic_nervous0.91332256
91MP0002152_abnormal_brain_morphology0.89807319
92MP0000639_abnormal_adrenal_gland0.88963864
93MP0010234_abnormal_vibrissa_follicle0.86542843
94MP0004043_abnormal_pH_regulation0.85916643
95MP0005535_abnormal_body_temperature0.84379830
96MP0001963_abnormal_hearing_physiology0.83256599
97MP0000015_abnormal_ear_pigmentation0.83175414
98MP0003172_abnormal_lysosome_physiology0.82337768
99MP0001324_abnormal_eye_pigmentation0.80502072
100MP0004130_abnormal_muscle_cell0.79696828
101MP0000383_abnormal_hair_follicle0.77867399
102MP0005551_abnormal_eye_electrophysiolog0.76444017
103MP0000920_abnormal_myelination0.76375600
104MP0001485_abnormal_pinna_reflex0.76230396
105MP0008874_decreased_physiological_sensi0.74612412
106MP0002233_abnormal_nose_morphology0.73680383
107MP0003136_yellow_coat_color0.73219065
108MP0002638_abnormal_pupillary_reflex0.70271586
109MP0003195_calcinosis0.68625782
110MP0004233_abnormal_muscle_weight0.68585494
111MP0005058_abnormal_lysosome_morphology0.68507560
112MP0001299_abnormal_eye_distance/0.66289482
113MP0003123_paternal_imprinting0.66275350
114MP0003121_genomic_imprinting0.65042897
115MP0005171_absent_coat_pigmentation0.65040971
116MP0004085_abnormal_heartbeat0.63533313
117MP0006035_abnormal_mitochondrial_morpho0.62870316
118MP0005623_abnormal_meninges_morphology0.60267917
119MP0002752_abnormal_somatic_nervous0.60079742
120MP0001664_abnormal_digestion0.59287996
121MP0003075_altered_response_to0.58616354
122MP0003283_abnormal_digestive_organ0.58283836
123MP0004484_altered_response_of0.58228296
124MP0004742_abnormal_vestibular_system0.55860374
125MP0004036_abnormal_muscle_relaxation0.54523580
126MP0004215_abnormal_myocardial_fiber0.54523372
127MP0000631_abnormal_neuroendocrine_gland0.54337217
128MP0004147_increased_porphyrin_level0.53015993
129MP0001943_abnormal_respiration0.52962669
130MP0004145_abnormal_muscle_electrophysio0.51152827
131MP0005448_abnormal_energy_balance0.50617019

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.07502627
2Myokymia (HP:0002411)5.94639498
3Focal seizures (HP:0007359)5.18971901
4Atonic seizures (HP:0010819)4.99680038
5Epileptic encephalopathy (HP:0200134)4.63911945
6Visual hallucinations (HP:0002367)4.44412617
7Febrile seizures (HP:0002373)4.11249491
8Absence seizures (HP:0002121)4.06389798
9Pheochromocytoma (HP:0002666)4.00703391
10Progressive cerebellar ataxia (HP:0002073)3.88469547
11Dialeptic seizures (HP:0011146)3.79135788
12Papillary thyroid carcinoma (HP:0002895)3.75977096
13Neuroendocrine neoplasm (HP:0100634)3.69714273
14Generalized tonic-clonic seizures (HP:0002069)3.68347149
15Hyperventilation (HP:0002883)3.67252618
16Action tremor (HP:0002345)3.35903691
17Abnormal eating behavior (HP:0100738)3.28389646
18Supranuclear gaze palsy (HP:0000605)3.27463404
19Impaired vibration sensation in the lower limbs (HP:0002166)3.07698114
20Thyroid carcinoma (HP:0002890)3.02103405
21Polyphagia (HP:0002591)3.01295695
22Insidious onset (HP:0003587)2.92558083
23Termporal pattern (HP:0011008)2.92558083
24Abnormality of glycolipid metabolism (HP:0010969)2.91774364
25Abnormality of liposaccharide metabolism (HP:0010968)2.91774364
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.91774364
27Genital tract atresia (HP:0001827)2.91311892
28Ankle clonus (HP:0011448)2.83578357
29Truncal ataxia (HP:0002078)2.81849749
30Poor eye contact (HP:0000817)2.81766304
31Resting tremor (HP:0002322)2.81754773
32Depression (HP:0000716)2.77170218
33Dysdiadochokinesis (HP:0002075)2.76725679
34Anxiety (HP:0000739)2.76356210
35Epileptiform EEG discharges (HP:0011182)2.73005499
36Broad-based gait (HP:0002136)2.72583208
37Gaze-evoked nystagmus (HP:0000640)2.70773366
38Vaginal atresia (HP:0000148)2.70280765
39Increased circulating renin level (HP:0000848)2.65308222
40Abnormal social behavior (HP:0012433)2.63821809
41Impaired social interactions (HP:0000735)2.63821809
42Neurofibrillary tangles (HP:0002185)2.62710477
43Amyotrophic lateral sclerosis (HP:0007354)2.60705407
44EEG with generalized epileptiform discharges (HP:0011198)2.58780230
45Absent speech (HP:0001344)2.58607281
46Cerebral inclusion bodies (HP:0100314)2.58582629
47Gait imbalance (HP:0002141)2.57005077
48Torticollis (HP:0000473)2.53797502
49Abnormal hair whorl (HP:0010721)2.53404282
50Amblyopia (HP:0000646)2.52703893
51Urinary bladder sphincter dysfunction (HP:0002839)2.51731983
52Intestinal atresia (HP:0011100)2.51718916
53Failure to thrive in infancy (HP:0001531)2.51052521
54Urinary urgency (HP:0000012)2.50944468
55Hypsarrhythmia (HP:0002521)2.50691768
56Mutism (HP:0002300)2.50643177
57Postural instability (HP:0002172)2.47862814
58Scanning speech (HP:0002168)2.47079119
59Oligomenorrhea (HP:0000876)2.46837486
60Limb dystonia (HP:0002451)2.45843973
61Abnormality of the lower motor neuron (HP:0002366)2.44619527
62Neoplasm of the peripheral nervous system (HP:0100007)2.43729834
63Spastic gait (HP:0002064)2.43397503
64Progressive inability to walk (HP:0002505)2.42868492
65Focal dystonia (HP:0004373)2.41892898
66Drooling (HP:0002307)2.41506749
67Excessive salivation (HP:0003781)2.41506749
68Dysmetria (HP:0001310)2.40061008
69Pancreatic fibrosis (HP:0100732)2.39599926
70Diplopia (HP:0000651)2.36785444
71Abnormality of binocular vision (HP:0011514)2.36785444
72Bradykinesia (HP:0002067)2.30931549
73Lower limb muscle weakness (HP:0007340)2.28350579
74Specific learning disability (HP:0001328)2.26825259
75Congenital primary aphakia (HP:0007707)2.24926926
76Agitation (HP:0000713)2.24622380
77Pancreatic cysts (HP:0001737)2.24223329
78Craniofacial dystonia (HP:0012179)2.23488584
79Poor suck (HP:0002033)2.23353813
80Abnormality of pain sensation (HP:0010832)2.22484354
81Impaired pain sensation (HP:0007328)2.22484354
82Abnormality of the corticospinal tract (HP:0002492)2.19753763
83Poor coordination (HP:0002370)2.19664261
84Fetal akinesia sequence (HP:0001989)2.19605723
85Impaired vibratory sensation (HP:0002495)2.18406110
86Impaired smooth pursuit (HP:0007772)2.17706903
87Akinesia (HP:0002304)2.17412125
88Hypothermia (HP:0002045)2.16674390
89Status epilepticus (HP:0002133)2.14873962
90Atrophy/Degeneration involving motor neurons (HP:0007373)2.14274106
91Mitral stenosis (HP:0001718)2.13513657
92Generalized myoclonic seizures (HP:0002123)2.12358023
93Medial flaring of the eyebrow (HP:0010747)2.08144387
94Nephrogenic diabetes insipidus (HP:0009806)2.08098154
95Intention tremor (HP:0002080)2.07672215
96True hermaphroditism (HP:0010459)2.06905844
97Gait ataxia (HP:0002066)2.02478267
98Inability to walk (HP:0002540)2.00778864
99Delusions (HP:0000746)1.99910585
100Renal cortical cysts (HP:0000803)1.98156199
101Postural tremor (HP:0002174)1.97656982
102Volvulus (HP:0002580)1.97387709
103Aplasia/Hypoplasia of the lens (HP:0008063)1.97021196
104Neuronal loss in central nervous system (HP:0002529)1.95703444
105Dysmetric saccades (HP:0000641)1.95362954
106Abnormality of ocular smooth pursuit (HP:0000617)1.94701661
107Cholecystitis (HP:0001082)1.94559412
108Abnormal gallbladder physiology (HP:0012438)1.94559412
109Tetraplegia (HP:0002445)1.94297863
110Metaphyseal dysplasia (HP:0100255)1.92561369
111Hypoglycemic coma (HP:0001325)1.92139600
112Widely spaced teeth (HP:0000687)1.91736829
113Pachygyria (HP:0001302)1.90203500
114Paraplegia (HP:0010550)1.89964787
115Hypoventilation (HP:0002791)1.89498177
116Abnormality of the labia minora (HP:0012880)1.88780968
117Hemiparesis (HP:0001269)1.85606291
118Clonus (HP:0002169)1.84994196
119Spastic tetraplegia (HP:0002510)1.84833265
120Blue irides (HP:0000635)1.83599676
121Rigidity (HP:0002063)1.82756013
122Hematochezia (HP:0002573)1.82168318
123Heterochromia iridis (HP:0001100)1.82062413
124Increased serum pyruvate (HP:0003542)1.80333381
125Abnormality of glycolysis (HP:0004366)1.80333381
126Postaxial hand polydactyly (HP:0001162)1.79686097
127Abnormal mitochondria in muscle tissue (HP:0008316)1.78396652
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78119338
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.78119338
130Abnormality of the anterior horn cell (HP:0006802)1.77284070
131Degeneration of anterior horn cells (HP:0002398)1.77284070
132Short foot (HP:0001773)1.76995635
133Aqueductal stenosis (HP:0002410)1.76131285
134Hemiplegia (HP:0002301)1.74945269
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.73902990
136Tongue fasciculations (HP:0001308)1.71267052
137Split foot (HP:0001839)1.70973246
138Ketoacidosis (HP:0001993)1.69916809
139Decreased testicular size (HP:0008734)1.69793920
140Abnormality of salivation (HP:0100755)1.68638108
141Broad foot (HP:0001769)1.67595376
142Abolished electroretinogram (ERG) (HP:0000550)1.67228696
143Neoplasm of the thyroid gland (HP:0100031)1.65637225
144Growth hormone deficiency (HP:0000824)1.65276566
145Vacuolated lymphocytes (HP:0001922)1.64227603
146Oligodactyly (hands) (HP:0001180)1.64148661
147Patchy hypopigmentation of hair (HP:0011365)1.63546590
148Hamartoma of the eye (HP:0010568)1.63452771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.98172484
2CASK3.57585819
3MAP3K93.36347717
4MAP3K43.35150011
5EPHA43.07908854
6MAP3K123.06170498
7MAP2K72.90305144
8MINK12.59205307
9DAPK22.48252504
10MARK12.43025475
11MAP4K22.25125950
12STK38L2.20123907
13PLK22.14751237
14MAP2K42.14176851
15ARAF1.95543197
16CDK191.86620989
17EPHA31.86210340
18KSR21.80563488
19DAPK11.79421782
20ACVR1B1.70880735
21AKT31.58410941
22PAK61.57777047
23NTRK21.57635999
24GRK51.50945768
25NTRK11.48502853
26PRPF4B1.46714329
27BCR1.43739904
28CDK51.38023410
29CAMKK11.37475870
30PRKCG1.36999000
31KSR11.36810381
32CSNK1A1L1.35117399
33OXSR11.33709352
34SGK2231.31166786
35SGK4941.31166786
36LMTK21.30240200
37MST41.28565039
38CAMKK21.25495593
39PRKD31.24867165
40TRIM281.23067102
41CSNK1G11.22742063
42NEK11.20820647
43PDK41.20567819
44PDK31.20567819
45CCNB11.19477512
46SGK21.15243130
47ADRBK21.15178483
48MAPK131.14797566
49TSSK61.06710628
50MAP3K21.05494101
51RIPK41.03812390
52EIF2AK31.00343585
53PHKG10.99539788
54PHKG20.99539788
55CAMK2A0.96572038
56GRK70.95654280
57PAK30.95144028
58SCYL20.94712199
59PTK2B0.92785062
60NME10.91276406
61EIF2AK10.89752385
62CDK140.87412812
63RET0.86455048
64CDK180.86437797
65GRK10.85706195
66STK380.82286884
67PNCK0.79585694
68SGK30.79499786
69FER0.79055640
70CDK150.78877227
71PRKCE0.78300733
72LATS20.77149878
73WNK30.76108806
74CAMK2B0.75707870
75MAP3K130.75544364
76CSNK1G20.75395935
77LIMK10.75123654
78PDK20.74026377
79STK390.71330991
80JAK10.71061746
81TRPM70.70170970
82MAP2K10.70000667
83PRKCH0.68407928
84TIE10.67981193
85SIK30.67579948
86BRAF0.64615703
87CDK11A0.63682145
88NEK60.63465058
89TNIK0.63307310
90ADRBK10.63297357
91UHMK10.62351777
92SGK10.56038513
93DYRK1A0.55752487
94CAMK2G0.55403756
95MET0.54322749
96RAF10.52876291
97YES10.52142300
98FGFR20.52112845
99MAP2K60.51924969
100TYRO30.50871695
101DAPK30.50619322
102PRKACB0.50166015
103MKNK20.50148074
104FGR0.49951836
105MYLK0.49877922
106ERBB20.49596242
107TAOK30.47947450
108STK240.47702981
109SIK20.47014121
110EGFR0.46178701
111FRK0.44458849
112FLT30.44170301
113PDPK10.43469087
114CAMK1G0.43017593
115JAK20.42975096
116PINK10.42088875
117BMPR20.41273950
118WNK10.40933275
119PDK10.40495792
120NEK90.39984314
121BMPR1B0.39782502
122CSNK1G30.39275219
123CSNK1D0.39270811
124STK110.38989678
125RPS6KA30.38927472
126PRKCZ0.38897146
127DYRK20.37902136
128CAMK2D0.37866527
129CAMK10.37822481
130DDR20.37799372
131BLK0.37495772
132ABL10.36966089
133MKNK10.36006114
134IGF1R0.35578915
135ROCK20.34851762
136PRKG10.33657060
137ERBB30.32724536
138FYN0.32344674

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.27914421
2Nicotine addiction_Homo sapiens_hsa050333.46787426
3Collecting duct acid secretion_Homo sapiens_hsa049663.05931542
4GABAergic synapse_Homo sapiens_hsa047272.60258481
5Olfactory transduction_Homo sapiens_hsa047402.47667723
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43576401
7Circadian entrainment_Homo sapiens_hsa047132.26626608
8Morphine addiction_Homo sapiens_hsa050322.19040401
9Vibrio cholerae infection_Homo sapiens_hsa051102.13055932
10Protein export_Homo sapiens_hsa030602.08913280
11Amphetamine addiction_Homo sapiens_hsa050312.08147673
12Long-term potentiation_Homo sapiens_hsa047202.05879189
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03871942
14Glutamatergic synapse_Homo sapiens_hsa047242.01031876
15Dopaminergic synapse_Homo sapiens_hsa047281.96083575
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95002111
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88496808
18Insulin secretion_Homo sapiens_hsa049111.78175045
19Salivary secretion_Homo sapiens_hsa049701.64686491
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62385580
21Cholinergic synapse_Homo sapiens_hsa047251.53052803
22Taste transduction_Homo sapiens_hsa047421.51840324
23Renin secretion_Homo sapiens_hsa049241.50745355
24Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48765635
25Serotonergic synapse_Homo sapiens_hsa047261.47489131
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43337956
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38521802
28Gastric acid secretion_Homo sapiens_hsa049711.37808158
29Long-term depression_Homo sapiens_hsa047301.37140433
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.35735109
31Circadian rhythm_Homo sapiens_hsa047101.35615471
32Cocaine addiction_Homo sapiens_hsa050301.34262008
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28668356
34Oxidative phosphorylation_Homo sapiens_hsa001901.28613765
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26088881
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25768193
37Oxytocin signaling pathway_Homo sapiens_hsa049211.24059809
38Calcium signaling pathway_Homo sapiens_hsa040201.23703947
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22996094
40Steroid biosynthesis_Homo sapiens_hsa001001.21664488
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19884591
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17938302
43Sphingolipid metabolism_Homo sapiens_hsa006001.14322560
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.13088244
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12540219
46Gap junction_Homo sapiens_hsa045401.11124515
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.10494949
48Peroxisome_Homo sapiens_hsa041461.09611671
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07726487
50Nitrogen metabolism_Homo sapiens_hsa009101.06513374
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04439554
52Sulfur metabolism_Homo sapiens_hsa009201.02216704
53Butanoate metabolism_Homo sapiens_hsa006501.00005524
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99573517
55GnRH signaling pathway_Homo sapiens_hsa049120.98093963
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96616410
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95868456
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95536421
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94792672
60Type II diabetes mellitus_Homo sapiens_hsa049300.92988123
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92806933
62Rheumatoid arthritis_Homo sapiens_hsa053230.92598931
63Ether lipid metabolism_Homo sapiens_hsa005650.91970701
64Tryptophan metabolism_Homo sapiens_hsa003800.88640081
65Pyruvate metabolism_Homo sapiens_hsa006200.87512111
66Phagosome_Homo sapiens_hsa041450.86599053
67Vitamin B6 metabolism_Homo sapiens_hsa007500.86453154
68Parkinsons disease_Homo sapiens_hsa050120.86441253
69cAMP signaling pathway_Homo sapiens_hsa040240.86103459
70Alzheimers disease_Homo sapiens_hsa050100.85138997
71ABC transporters_Homo sapiens_hsa020100.82888724
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82219411
73Glioma_Homo sapiens_hsa052140.81036121
74Mineral absorption_Homo sapiens_hsa049780.79960917
75Estrogen signaling pathway_Homo sapiens_hsa049150.79597030
76ErbB signaling pathway_Homo sapiens_hsa040120.79554436
77Type I diabetes mellitus_Homo sapiens_hsa049400.77807321
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77783083
79Cardiac muscle contraction_Homo sapiens_hsa042600.75010905
80beta-Alanine metabolism_Homo sapiens_hsa004100.73446827
81Axon guidance_Homo sapiens_hsa043600.73381367
82Fatty acid metabolism_Homo sapiens_hsa012120.70807968
83Selenocompound metabolism_Homo sapiens_hsa004500.68949170
84Arginine biosynthesis_Homo sapiens_hsa002200.65729937
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63709930
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63550517
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60343695
88Melanogenesis_Homo sapiens_hsa049160.59589744
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.58022346
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57092744
91Glucagon signaling pathway_Homo sapiens_hsa049220.56640411
92Oocyte meiosis_Homo sapiens_hsa041140.56571482
93Thyroid hormone synthesis_Homo sapiens_hsa049180.54500976
94Prion diseases_Homo sapiens_hsa050200.52591910
95Regulation of autophagy_Homo sapiens_hsa041400.51974291
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51467408
97Phototransduction_Homo sapiens_hsa047440.50940835
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47939573
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47025720
100Ovarian steroidogenesis_Homo sapiens_hsa049130.45859845
101Bile secretion_Homo sapiens_hsa049760.45685671
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43536690
103Carbon metabolism_Homo sapiens_hsa012000.42529330
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.41623322
105Lysosome_Homo sapiens_hsa041420.41316983
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41011367
107Pancreatic secretion_Homo sapiens_hsa049720.40989112
108Ras signaling pathway_Homo sapiens_hsa040140.40864343
109MAPK signaling pathway_Homo sapiens_hsa040100.39735266
110Endocytosis_Homo sapiens_hsa041440.39716217
111Huntingtons disease_Homo sapiens_hsa050160.38504787
112Propanoate metabolism_Homo sapiens_hsa006400.38308993
113Dilated cardiomyopathy_Homo sapiens_hsa054140.35754513
114Insulin signaling pathway_Homo sapiens_hsa049100.35501069
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.34552322
116Tight junction_Homo sapiens_hsa045300.33915022
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.33792305
118Dorso-ventral axis formation_Homo sapiens_hsa043200.33579107
119mTOR signaling pathway_Homo sapiens_hsa041500.31848778
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29784498
121Platelet activation_Homo sapiens_hsa046110.29642276
122Fructose and mannose metabolism_Homo sapiens_hsa000510.29293807
123Inositol phosphate metabolism_Homo sapiens_hsa005620.28304140
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27987014
125Choline metabolism in cancer_Homo sapiens_hsa052310.26214244
126Alcoholism_Homo sapiens_hsa050340.25955317
127Rap1 signaling pathway_Homo sapiens_hsa040150.25933429
128Fatty acid elongation_Homo sapiens_hsa000620.24650523
129Biosynthesis of amino acids_Homo sapiens_hsa012300.24602885

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