VPS37C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.44502702
2Golgi transport vesicle coating (GO:0048200)6.44502702
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.54331912
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.39407789
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.39407789
6protein retention in ER lumen (GO:0006621)4.24905168
7positive regulation of Cdc42 GTPase activity (GO:0043089)4.16085489
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.11229408
9protein localization to endosome (GO:0036010)4.10093115
10antigen processing and presentation of endogenous antigen (GO:0019883)3.98669170
11protein maturation by protein folding (GO:0022417)3.95037931
12macroautophagy (GO:0016236)3.94009397
13negative regulation of erythrocyte differentiation (GO:0045647)3.84124550
14COPII vesicle coating (GO:0048208)3.72797431
15activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.72652468
16signal peptide processing (GO:0006465)3.70999985
17positive regulation of nuclease activity (GO:0032075)3.61226388
18glycosphingolipid catabolic process (GO:0046479)3.46900934
19pentose-phosphate shunt (GO:0006098)3.38654278
20epithelial cell differentiation involved in prostate gland development (GO:0060742)3.32444209
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.31825772
22macrophage activation involved in immune response (GO:0002281)3.30611493
23mannose metabolic process (GO:0006013)3.27479867
24regulation of nuclease activity (GO:0032069)3.25087259
25endoplasmic reticulum unfolded protein response (GO:0030968)3.23193060
26sequestering of metal ion (GO:0051238)3.20620088
27cellular response to topologically incorrect protein (GO:0035967)3.19630790
28negative regulation of interleukin-12 production (GO:0032695)3.18001780
29regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.17555451
30cellular response to unfolded protein (GO:0034620)3.17005918
31ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.15954370
32membrane protein intracellular domain proteolysis (GO:0031293)3.15670108
33cellular response to thyroid hormone stimulus (GO:0097067)3.11903465
34glycolipid catabolic process (GO:0019377)3.11846601
35modulation by symbiont of host cellular process (GO:0044068)3.04960423
36low-density lipoprotein particle clearance (GO:0034383)3.04574037
37regulation of vitamin D biosynthetic process (GO:0060556)3.03471512
38barbed-end actin filament capping (GO:0051016)3.00461584
39regulation of early endosome to late endosome transport (GO:2000641)3.00380368
40ER-nucleus signaling pathway (GO:0006984)3.00041721
41L-alpha-amino acid transmembrane transport (GO:1902475)2.97790944
42amyloid precursor protein catabolic process (GO:0042987)2.97503240
43NIK/NF-kappaB signaling (GO:0038061)2.96903252
44NADPH regeneration (GO:0006740)2.96462259
45regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95200886
46vesicle coating (GO:0006901)2.92803472
47pinocytosis (GO:0006907)2.92485803
48positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.91797057
49neutrophil activation involved in immune response (GO:0002283)2.89156383
50negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86948262
51regulation of hydrogen peroxide-induced cell death (GO:1903205)2.86261153
52regulation of podosome assembly (GO:0071801)2.84578551
53regulation of leukocyte degranulation (GO:0043300)2.83879528
54JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.80203190
55response to misfolded protein (GO:0051788)2.79262371
56germinal center formation (GO:0002467)2.79130615
57epithelial cell-cell adhesion (GO:0090136)2.78753873
58response to thyroid hormone (GO:0097066)2.78697188
59response to muramyl dipeptide (GO:0032495)2.77171654
60beta-amyloid metabolic process (GO:0050435)2.76834290
61regulation of T-helper 2 cell differentiation (GO:0045628)2.76088540
62response to laminar fluid shear stress (GO:0034616)2.75369774
63detection of molecule of bacterial origin (GO:0032490)2.73856313
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73778475
65apoptotic cell clearance (GO:0043277)2.73217759
66regulation of mast cell degranulation (GO:0043304)2.72596116
67glucose 6-phosphate metabolic process (GO:0051156)2.71256535
68regulation of cholesterol homeostasis (GO:2000188)2.71020832
69positive regulation of cellular amide metabolic process (GO:0034250)2.66780870
70tricarboxylic acid metabolic process (GO:0072350)2.66493542
71sexual reproduction (GO:0019953)2.65583794
724-hydroxyproline metabolic process (GO:0019471)2.65342498
73decidualization (GO:0046697)2.65207142
74regulation of type B pancreatic cell apoptotic process (GO:2000674)2.65138751
75modulation by symbiont of host defense response (GO:0052031)2.64758026
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64758026
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64758026
78positive regulation by organism of defense response of other organism involved in symbiotic interact2.64758026
79modulation by symbiont of host immune response (GO:0052553)2.64758026
80positive regulation by symbiont of host defense response (GO:0052509)2.64758026
81regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64736507
82positive regulation of histone deacetylation (GO:0031065)2.63242501
83leukocyte aggregation (GO:0070486)2.62655059
84response to endoplasmic reticulum stress (GO:0034976)2.60671424
85antigen processing and presentation via MHC class Ib (GO:0002475)2.59283152
86negative regulation of cell size (GO:0045792)2.56912676
87cell-cell junction maintenance (GO:0045217)2.56365275
88coronary vasculature morphogenesis (GO:0060977)2.56337493
89regulation of vitamin metabolic process (GO:0030656)2.56199623
90regulation of cholesterol storage (GO:0010885)2.55928369
91response to peptidoglycan (GO:0032494)2.54721761
92modulation by virus of host process (GO:0019054)2.54230940
93ceramide catabolic process (GO:0046514)2.54217557
94growth hormone receptor signaling pathway (GO:0060396)2.53573307
95ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.52934602
96cellular response to nicotine (GO:0071316)2.52701013
97detection of other organism (GO:0098543)2.52482271
98adhesion of symbiont to host cell (GO:0044650)2.50636145
99virion attachment to host cell (GO:0019062)2.50636145
100embryo implantation (GO:0007566)2.50305048
101cellular response to nutrient (GO:0031670)2.49617855
102positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49568802
103positive regulation of receptor recycling (GO:0001921)2.49260338
104skin morphogenesis (GO:0043589)2.48872984
105positive regulation of heat generation (GO:0031652)2.48487159
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.48235151
107maternal placenta development (GO:0001893)2.47636163
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47618628
109creatine metabolic process (GO:0006600)2.47561338
110amino sugar catabolic process (GO:0046348)2.46488884
111protein autoprocessing (GO:0016540)2.46332988
112exocrine pancreas development (GO:0031017)2.45871613
113membrane lipid catabolic process (GO:0046466)2.45673071
114positive regulation of lamellipodium assembly (GO:0010592)2.45260901
115branching involved in mammary gland duct morphogenesis (GO:0060444)2.45229587
116regulation of necroptotic process (GO:0060544)2.43997973
117regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.43794007
118oligosaccharide catabolic process (GO:0009313)2.43469462
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.42792426
120response to host (GO:0075136)2.42792426
121response to host defenses (GO:0052200)2.42792426
122regulation of autophagic vacuole assembly (GO:2000785)2.42337288
123regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42139841
124positive regulation of leukocyte degranulation (GO:0043302)2.42103117
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41673258
126response to host immune response (GO:0052572)2.41673258
127granulocyte activation (GO:0036230)2.41187014
128nucleoside diphosphate catabolic process (GO:0009134)2.40262933
129adherens junction assembly (GO:0034333)2.40132384
130negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.40084261
131positive regulation of steroid biosynthetic process (GO:0010893)2.39952362
132positive regulation of keratinocyte differentiation (GO:0045618)2.38923699
133glucose catabolic process (GO:0006007)2.38101723
134response to topologically incorrect protein (GO:0035966)2.37905502
135sphingolipid catabolic process (GO:0030149)2.36988418
136detection of external biotic stimulus (GO:0098581)2.36584919
137response to progesterone (GO:0032570)2.35619012
138vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.35499513
139response to unfolded protein (GO:0006986)2.35399025
140T-helper 1 type immune response (GO:0042088)2.34998544
141apoptotic process involved in morphogenesis (GO:0060561)2.34138662
142regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33951687
143regulation of regulated secretory pathway (GO:1903305)2.32672931
144cellular response to arsenic-containing substance (GO:0071243)2.32603790
145negative regulation of necroptotic process (GO:0060546)2.32457754
146detection of bacterium (GO:0016045)2.32306296
147positive regulation of p38MAPK cascade (GO:1900745)2.31950646
148activation of MAPKKK activity (GO:0000185)2.31690161
149negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31489469
150regulation of mast cell activation involved in immune response (GO:0033006)2.31282835
151localization within membrane (GO:0051668)2.31028224
152cytoskeletal anchoring at plasma membrane (GO:0007016)2.30907816
153respiratory burst (GO:0045730)2.30646442
154plasma membrane repair (GO:0001778)2.30570077
155negative regulation of protein localization to plasma membrane (GO:1903077)2.30326218
156negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.29871344
157negative regulation of cell killing (GO:0031342)2.29871344
158positive regulation of chemokine biosynthetic process (GO:0045080)2.29440848
159lipopolysaccharide-mediated signaling pathway (GO:0031663)2.28550043
160negative regulation of interleukin-8 production (GO:0032717)2.28325078
161cell adhesion mediated by integrin (GO:0033627)2.28126262
162regulation of interferon-beta biosynthetic process (GO:0045357)2.28074640
163endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.27827006
164stress fiber assembly (GO:0043149)2.27657717
165peptidyl-asparagine modification (GO:0018196)2.27057210
166response to type I interferon (GO:0034340)2.26192266
167myeloid dendritic cell differentiation (GO:0043011)2.25925204
168mitochondrial calcium ion transport (GO:0006851)2.25852236
169protein N-linked glycosylation via asparagine (GO:0018279)2.25640750
170cellular extravasation (GO:0045123)2.25559745
171cell-substrate adherens junction assembly (GO:0007045)2.25528641
172focal adhesion assembly (GO:0048041)2.25528641
173type I interferon signaling pathway (GO:0060337)2.24735821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.05354899
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.94817199
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74693224
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.71571005
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24688194
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24518115
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.23519019
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22445061
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16495394
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.16182058
11VDR_21846776_ChIP-Seq_THP-1_Human2.14598500
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.09865712
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07010185
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05181462
15MYC_22102868_ChIP-Seq_BL_Human2.02726852
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00708401
17LXR_22292898_ChIP-Seq_THP-1_Human1.99280684
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97933521
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95009336
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.90367409
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.88273179
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88082166
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85708377
24* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83313539
25ZNF263_19887448_ChIP-Seq_K562_Human1.78105368
26VDR_24763502_ChIP-Seq_THP-1_Human1.73685211
27SPI1_23127762_ChIP-Seq_K562_Human1.73450780
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72736747
29* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72214787
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.71776934
31KDM2B_26808549_Chip-Seq_K562_Human1.71163859
32KDM2B_26808549_Chip-Seq_DND41_Human1.71109520
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68412396
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63616181
35* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62854242
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.62200786
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.60215046
38CLOCK_20551151_ChIP-Seq_293T_Human1.60176838
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.58219672
40MAF_26560356_Chip-Seq_TH1_Human1.58109442
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.56641868
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56344220
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54190049
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54083506
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54016901
46* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49674999
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46228593
48UTX_26944678_Chip-Seq_JUKART_Human1.44086272
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.43563813
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42963569
51SCL_19346495_ChIP-Seq_HPC-7_Human1.41172727
52* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41060783
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.40162599
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40102836
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40088569
56MYB_26560356_Chip-Seq_TH2_Human1.37972899
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37275833
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36980645
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36503534
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34885537
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34868461
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34280088
63TFEB_21752829_ChIP-Seq_HELA_Human1.32226060
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.30762394
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30090365
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.29098683
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28917415
68NCOR1_26117541_ChIP-Seq_K562_Human1.28571429
69ATF3_27146783_Chip-Seq_COLON_Human1.27999643
70GATA1_22025678_ChIP-Seq_K562_Human1.27717367
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26944355
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26861237
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.26649342
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26576772
75SMC4_20622854_ChIP-Seq_HELA_Human1.26417224
76* RUNX1_27514584_Chip-Seq_MCF-7_Human1.26166513
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25508175
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25122222
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.24570658
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.24192305
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23641762
82CREB1_26743006_Chip-Seq_LNCaP_Human1.23387493
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23035940
84* SPI1_23547873_ChIP-Seq_NB4_Human1.22717544
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22381310
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22062782
87BCL6_27268052_Chip-Seq_Bcells_Human1.21716767
88* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19487902
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19045292
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.18966689
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.18966689
92BCOR_27268052_Chip-Seq_Bcells_Human1.18798591
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.18588274
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16616529
95GATA1_19941826_ChIP-Seq_K562_Human1.16573690
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15940572
97GATA3_27048872_Chip-Seq_THYMUS_Human1.15660463
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14480303
99* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14177258
100STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13488305
101* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13115745
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11594110
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11270395
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10900432
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10664909
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.09536714
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08599782
108* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08434846
109MYB_26560356_Chip-Seq_TH1_Human1.07414280
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.07325444
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07239657
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07041976
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06942359
114* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06181748
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05833162
116P68_20966046_ChIP-Seq_HELA_Human1.05786136
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05660032
118* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05558740
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04788992
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03597281
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03055524
122* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02821318
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02188458
124RUNX_20019798_ChIP-Seq_JUKART_Human1.02151891
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01616649
126GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00689543
127EGR1_19032775_ChIP-ChIP_M12_Human1.00517830
128* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99586178
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99399187
130MAF_26560356_Chip-Seq_TH2_Human0.99378460
131PU_27001747_Chip-Seq_BMDM_Mouse0.99376919
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99033662
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98452190
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98421646
135* ESR1_20079471_ChIP-ChIP_T-47D_Human0.98229575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.84678521
2MP0003183_abnormal_peptide_metabolism3.14395466
3MP0005058_abnormal_lysosome_morphology3.03143500
4MP0003300_gastrointestinal_ulcer2.95019324
5MP0010234_abnormal_vibrissa_follicle2.81891482
6MP0003303_peritoneal_inflammation2.81598052
7MP0009840_abnormal_foam_cell2.71202582
8MP0003436_decreased_susceptibility_to2.69254290
9MP0004858_abnormal_nervous_system2.62802384
10MP0008260_abnormal_autophagy2.62091192
11MP0002837_dystrophic_cardiac_calcinosis2.29292368
12MP0003172_abnormal_lysosome_physiology2.16609444
13MP0000685_abnormal_immune_system2.07383288
14MP0003329_amyloid_beta_deposits2.01753848
15MP0002796_impaired_skin_barrier1.97418541
16MP0004947_skin_inflammation1.97297795
17MP0003705_abnormal_hypodermis_morpholog1.96413613
18MP0008438_abnormal_cutaneous_collagen1.87676565
19MP0004510_myositis1.87070855
20MP0000604_amyloidosis1.85018882
21MP0009278_abnormal_bone_marrow1.78601934
22MP0001849_ear_inflammation1.78116555
23MP0009785_altered_susceptibility_to1.75368547
24MP0002877_abnormal_melanocyte_morpholog1.74599320
25MP0002148_abnormal_hypersensitivity_rea1.70782150
26MP0001533_abnormal_skeleton_physiology1.66370027
27MP0004233_abnormal_muscle_weight1.65657679
28MP0005083_abnormal_biliary_tract1.65492161
29MP0001835_abnormal_antigen_presentation1.63368910
30MP0005000_abnormal_immune_tolerance1.62844134
31MP0003195_calcinosis1.61010074
32MP0002254_reproductive_system_inflammat1.60894608
33MP0002419_abnormal_innate_immunity1.60653557
34MP0005025_abnormal_response_to1.56805351
35MP0005387_immune_system_phenotype1.55728730
36MP0001790_abnormal_immune_system1.55728730
37MP0003566_abnormal_cell_adhesion1.55085013
38MP0000678_abnormal_parathyroid_gland1.48971431
39MP0003656_abnormal_erythrocyte_physiolo1.44147777
40MP0000749_muscle_degeneration1.43228962
41MP0003075_altered_response_to1.36347114
42MP0000343_altered_response_to1.35701286
43MP0004185_abnormal_adipocyte_glucose1.29534304
44MP0001545_abnormal_hematopoietic_system1.29491699
45MP0005397_hematopoietic_system_phenotyp1.29491699
46MP0002723_abnormal_immune_serum1.28787415
47MP0000003_abnormal_adipose_tissue1.27210481
48MP0008004_abnormal_stomach_pH1.26780001
49MP0003448_altered_tumor_morphology1.26209133
50MP0006054_spinal_hemorrhage1.25866966
51MP0000013_abnormal_adipose_tissue1.23249347
52MP0002693_abnormal_pancreas_physiology1.23200877
53MP0002452_abnormal_antigen_presenting1.23138538
54MP0005257_abnormal_intraocular_pressure1.21138721
55MP0005023_abnormal_wound_healing1.20909780
56MP0005220_abnormal_exocrine_pancreas1.20331517
57MP0002269_muscular_atrophy1.18533266
58MP0003828_pulmonary_edema1.18502651
59MP0005464_abnormal_platelet_physiology1.18310090
60MP0005409_darkened_coat_color1.18141035
61MP0008961_abnormal_basal_metabolism1.17013746
62MP0001845_abnormal_inflammatory_respons1.16591711
63MP0003724_increased_susceptibility_to1.16499515
64MP0000858_altered_metastatic_potential1.16297216
65MP0005310_abnormal_salivary_gland1.15729481
66MP0001800_abnormal_humoral_immune1.15152299
67MP0000751_myopathy1.15057962
68MP0005501_abnormal_skin_physiology1.14320194
69MP0001853_heart_inflammation1.13278376
70MP0000750_abnormal_muscle_regeneration1.12742125
71MP0005076_abnormal_cell_differentiation1.12324668
72MP0004130_abnormal_muscle_cell1.11548900
73MP0004087_abnormal_muscle_fiber1.11096293
74MP0001819_abnormal_immune_cell1.10685613
75MP0002998_abnormal_bone_remodeling1.09403761
76MP0003011_delayed_dark_adaptation1.09328065
77MP0002420_abnormal_adaptive_immunity1.08397763
78MP0002933_joint_inflammation1.06134301
79MP0002405_respiratory_system_inflammati1.04891888
80MP0006082_CNS_inflammation1.04752196
81MP0003279_aneurysm1.03795480
82MP0002909_abnormal_adrenal_gland1.03555455
83MP0003191_abnormal_cellular_cholesterol1.03094636
84MP0001944_abnormal_pancreas_morphology1.02846991
85MP0008469_abnormal_protein_level1.02455795
86MP0009333_abnormal_splenocyte_physiolog1.01907456
87MP0009643_abnormal_urine_homeostasis1.01220760
88MP0000747_muscle_weakness0.99681710
89MP0004036_abnormal_muscle_relaxation0.99074570
90MP0003091_abnormal_cell_migration0.98511906
91MP0002896_abnormal_bone_mineralization0.96976762
92MP0010155_abnormal_intestine_physiology0.96880563
93MP0005666_abnormal_adipose_tissue0.96603640
94MP0010352_gastrointestinal_tract_polyps0.96513155
95MP0001216_abnormal_epidermal_layer0.96248831
96MP0003950_abnormal_plasma_membrane0.95568082
97MP0002163_abnormal_gland_morphology0.95342116
98MP0005166_decreased_susceptibility_to0.94310482
99MP0002166_altered_tumor_susceptibility0.91146976
100MP0004043_abnormal_pH_regulation0.90055367
101MP0003806_abnormal_nucleotide_metabolis0.89392305
102MP0001851_eye_inflammation0.89045482
103MP0003045_fibrosis0.88914124
104MP0005390_skeleton_phenotype0.88158769
105MP0005671_abnormal_response_to0.87909241
106MP0005379_endocrine/exocrine_gland_phen0.87054707
107MP0005375_adipose_tissue_phenotype0.85936826
108MP0002139_abnormal_hepatobiliary_system0.85684684
109MP0003795_abnormal_bone_structure0.85084829
110MP0002098_abnormal_vibrissa_morphology0.84377171
111MP0005174_abnormal_tail_pigmentation0.84143068
112MP0009764_decreased_sensitivity_to0.84071406
113MP0005167_abnormal_blood-brain_barrier0.83761329
114MP0001958_emphysema0.83747593
115MP0000767_abnormal_smooth_muscle0.83723948
116MP0000733_abnormal_muscle_development0.83619029
117MP0000490_abnormal_crypts_of0.83473016
118MP0002398_abnormal_bone_marrow0.83170731
119MP0000716_abnormal_immune_system0.82958923
120MP0004264_abnormal_extraembryonic_tissu0.82729257
121MP0002928_abnormal_bile_duct0.82571258
122MP0002106_abnormal_muscle_physiology0.82532901
123MP0001765_abnormal_ion_homeostasis0.82188646
124MP0001542_abnormal_bone_strength0.81926342
125MP0005330_cardiomyopathy0.79940930
126MP0003453_abnormal_keratinocyte_physiol0.79592330
127MP0004084_abnormal_cardiac_muscle0.79414872
128MP0002060_abnormal_skin_morphology0.78253260
129MP0005319_abnormal_enzyme/_coenzyme0.77274622
130MP0009931_abnormal_skin_appearance0.76980307
131MP0002332_abnormal_exercise_endurance0.76163087
132MP0005164_abnormal_response_to0.75949912
133MP0001727_abnormal_embryo_implantation0.72970931
134MP0002089_abnormal_postnatal_growth/wei0.71591589
135MP0008874_decreased_physiological_sensi0.64837251
136MP0005621_abnormal_cell_physiology0.63572088
137MP0003690_abnormal_glial_cell0.63427640

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)4.03387835
2Increased cerebral lipofuscin (HP:0011813)3.92135947
3Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.58939229
4Increased neuronal autofluorescent lipopigment (HP:0002074)3.56202476
5Elevated erythrocyte sedimentation rate (HP:0003565)3.53398807
6Mucopolysacchariduria (HP:0008155)3.43849039
7Urinary glycosaminoglycan excretion (HP:0003541)3.43849039
8Interstitial pulmonary disease (HP:0006530)3.31267864
9Eczematoid dermatitis (HP:0000976)3.23666676
10Distal lower limb muscle weakness (HP:0009053)3.15912620
11Abnormality of polysaccharide metabolism (HP:0011012)3.12986564
12Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12986564
13Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12986564
14Vacuolated lymphocytes (HP:0001922)3.07218405
15Thin bony cortex (HP:0002753)3.04333011
16Asymmetric septal hypertrophy (HP:0001670)2.93563105
17Thoracolumbar scoliosis (HP:0002944)2.93429752
18Axonal loss (HP:0003447)2.84934752
19Recurrent abscess formation (HP:0002722)2.83293256
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.77840427
21Abnormality of liposaccharide metabolism (HP:0010968)2.76094397
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.76094397
23Abnormality of glycolipid metabolism (HP:0010969)2.76094397
24Recurrent bacterial skin infections (HP:0005406)2.67311236
25Nuclear cataract (HP:0100018)2.66570897
26Myositis (HP:0100614)2.63449076
27Abnormality of macrophages (HP:0004311)2.52244638
28Retinal atrophy (HP:0001105)2.51806326
29Achilles tendon contracture (HP:0001771)2.47636419
30Exercise-induced myalgia (HP:0003738)2.43516600
31Distal lower limb amyotrophy (HP:0008944)2.41040601
32Distal upper limb amyotrophy (HP:0007149)2.40987283
33Upper limb amyotrophy (HP:0009129)2.40987283
34Myoglobinuria (HP:0002913)2.40361607
35Choroideremia (HP:0001139)2.36709147
36Hand muscle atrophy (HP:0009130)2.36129218
37Exercise-induced muscle cramps (HP:0003710)2.36083984
38Systemic lupus erythematosus (HP:0002725)2.32803466
39Late onset (HP:0003584)2.31708425
40Myopathic facies (HP:0002058)2.31275937
41Hypoglycemic coma (HP:0001325)2.24030398
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.23325038
43Beaking of vertebral bodies (HP:0004568)2.22910248
44Loss of speech (HP:0002371)2.22151988
45Segmental peripheral demyelination/remyelination (HP:0003481)2.21009571
46Abnormality of the distal phalanges of the toes (HP:0010182)2.20965046
47Myocardial infarction (HP:0001658)2.20761353
48Abnormality of the Achilles tendon (HP:0005109)2.20240021
49Malnutrition (HP:0004395)2.19676536
50Cerebral aneurysm (HP:0004944)2.19526686
51Peritonitis (HP:0002586)2.18641152
52Hyporeflexia of lower limbs (HP:0002600)2.18145446
53Neurofibrillary tangles (HP:0002185)2.17461746
54Neuronal loss in central nervous system (HP:0002529)2.17375221
55Cervical subluxation (HP:0003308)2.17343092
56Bone pain (HP:0002653)2.16946890
57Recurrent gram-negative bacterial infections (HP:0005420)2.16110950
58J-shaped sella turcica (HP:0002680)2.15216637
59Hyperparathyroidism (HP:0000843)2.12138227
60Nasal polyposis (HP:0100582)2.12003984
61Abnormality of the nasal mucosa (HP:0000433)2.11408421
62Hyperacusis (HP:0010780)2.09602010
63Obstructive sleep apnea (HP:0002870)2.08511743
64Distal arthrogryposis (HP:0005684)2.06127981
65Muscle fiber splitting (HP:0003555)2.05500089
66Polycythemia (HP:0001901)2.04663354
67Hyperinsulinemic hypoglycemia (HP:0000825)2.03025154
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02288754
69Vertebral compression fractures (HP:0002953)2.01876774
70Bulbar palsy (HP:0001283)2.01726546
71Diminished motivation (HP:0000745)2.01082795
72Limb-girdle muscle atrophy (HP:0003797)1.99314089
73Orchitis (HP:0100796)1.98871828
74Apathy (HP:0000741)1.98315096
75Pathologic fracture (HP:0002756)1.96193389
76Premature rupture of membranes (HP:0001788)1.96091201
77Difficulty climbing stairs (HP:0003551)1.95747518
78Ulnar deviation of the wrist (HP:0003049)1.95647107
79Protuberant abdomen (HP:0001538)1.94549183
80Increased serum ferritin (HP:0003281)1.94203180
81Difficulty running (HP:0009046)1.92080914
82Purpura (HP:0000979)1.92052404
83Progressive neurologic deterioration (HP:0002344)1.90069606
84Flat acetabular roof (HP:0003180)1.89679127
85Esophageal neoplasm (HP:0100751)1.89246455
86Neoplasm of head and neck (HP:0012288)1.89246455
87Type 1 muscle fiber predominance (HP:0003803)1.87103517
88Amyloidosis (HP:0011034)1.87100131
89Increased connective tissue (HP:0009025)1.86077700
90Cellulitis (HP:0100658)1.85925693
91Large for gestational age (HP:0001520)1.85779532
92Abnormality of the calcaneus (HP:0008364)1.84999188
93Mediastinal lymphadenopathy (HP:0100721)1.84712409
94Tetraparesis (HP:0002273)1.83910380
95Prolonged neonatal jaundice (HP:0006579)1.83796939
96Upper motor neuron abnormality (HP:0002127)1.83340975
97Ventricular tachycardia (HP:0004756)1.82928430
98Chronic otitis media (HP:0000389)1.82354758
99Abnormality of the thoracic spine (HP:0100711)1.82173110
100Obstructive lung disease (HP:0006536)1.81710782
101Chronic obstructive pulmonary disease (HP:0006510)1.81710782
102Increased IgE level (HP:0003212)1.81521081
103Protrusio acetabuli (HP:0003179)1.81087614
104Bony spicule pigmentary retinopathy (HP:0007737)1.80444787
105Metaphyseal cupping (HP:0003021)1.80169171
106Short nail (HP:0001799)1.80155834
107Urticaria (HP:0001025)1.79653706
108Recurrent bronchitis (HP:0002837)1.78035789
109Progressive visual loss (HP:0000529)1.77382654
110Hypoplasia of the odontoid process (HP:0003311)1.77143947
111Blue sclerae (HP:0000592)1.76954238
112EMG: myopathic abnormalities (HP:0003458)1.76703260
113Severe short stature (HP:0003510)1.76163449
114Long palpebral fissure (HP:0000637)1.74374520
115Poor head control (HP:0002421)1.74141421
116Hypophosphatemia (HP:0002148)1.74091599
117Abnormality of the odontoid process (HP:0003310)1.73410064
118Hypercortisolism (HP:0001578)1.73063926
119Frequent falls (HP:0002359)1.72410217
120Rapidly progressive (HP:0003678)1.72179418
121Gingivitis (HP:0000230)1.71561956
122Hemorrhage of the eye (HP:0011885)1.71163161
123Thoracic kyphosis (HP:0002942)1.70673671
124Stomatitis (HP:0010280)1.70371288
125Disinhibition (HP:0000734)1.69995602
126Abnormality of the lumbar spine (HP:0100712)1.69661605
127Disproportionate tall stature (HP:0001519)1.69157505
128Ketoacidosis (HP:0001993)1.68934470
129Supranuclear gaze palsy (HP:0000605)1.68353843
130Diaphragmatic weakness (HP:0009113)1.68351166
131Mildly elevated creatine phosphokinase (HP:0008180)1.67950829
132Broad face (HP:0000283)1.66467607
133Elevated alkaline phosphatase (HP:0003155)1.66415018
134Pheochromocytoma (HP:0002666)1.66012108
135Genu recurvatum (HP:0002816)1.65487928
136Abdominal distention (HP:0003270)1.65471942
137Esophageal varix (HP:0002040)1.65468067
138Petechiae (HP:0000967)1.65245568
139Cerebral inclusion bodies (HP:0100314)1.64165361
140Congenital glaucoma (HP:0001087)1.63312370
141Polygenic inheritance (HP:0010982)1.63072445
142Joint stiffness (HP:0001387)1.63072317
143Hypertensive crisis (HP:0100735)1.63027394
144Spinal rigidity (HP:0003306)1.62831142
145Long toe (HP:0010511)1.62826303
146Cardiomegaly (HP:0001640)1.62720881
147Aneurysm (HP:0002617)1.61690735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.21188575
2TRIB33.93786025
3EPHB13.25662137
4BCKDK2.80389705
5PRPF4B2.71503840
6SMG12.53735659
7NME22.46086722
8TBK12.43068956
9TTN2.19540476
10EPHA22.15532225
11TYK22.14434280
12TAOK22.07039994
13EPHA32.05346005
14TESK11.99181145
15PKN21.97785412
16SCYL21.94930081
17FGFR41.85756040
18MAP4K11.83962889
19WNK41.83661519
20MAPKAPK31.82434835
21MAP3K101.71975636
22PTK61.69832911
23TAOK31.63347899
24IRAK41.58654048
25JAK31.44841111
26PIM21.44108227
27ZAP701.39933957
28RIPK11.37943125
29TESK21.36708504
30EEF2K1.33995417
31MAP3K131.33624201
32ARAF1.33487830
33DDR21.26470875
34RPS6KA41.25551782
35MAPK151.23060861
36SIK11.19922375
37MAP3K11.19801906
38CDK121.19765601
39KIT1.17694496
40LRRK21.17655220
41LATS21.16331084
42IRAK21.16065582
43MAP2K31.14177313
44HIPK21.13334112
45DMPK1.11678062
46MAP3K111.09249971
47ICK1.07837687
48MATK1.07182007
49MARK21.06758362
50PRKD21.06505881
51IRAK31.05865948
52FLT31.01713255
53JAK11.01399406
54LMTK21.01029107
55FGR0.99369699
56MAP3K140.97837264
57PTK20.97152781
58CHUK0.94100766
59NTRK10.92474741
60LIMK10.92017319
61DYRK1B0.89493211
62BTK0.88804785
63IKBKE0.87856868
64PDPK10.87699961
65PASK0.87676580
66PDGFRA0.86774487
67RET0.85501909
68PHKG10.84353847
69PHKG20.84353847
70TNK20.82720955
71PRKD30.81753298
72PIK3CG0.80323905
73JAK20.80183952
74IKBKB0.79935841
75CSK0.79590702
76PAK40.78984108
77RPS6KL10.77472565
78RPS6KC10.77472565
79MAP3K60.75792492
80CAMK1D0.74541935
81STK100.73466048
82PBK0.73173187
83MAP3K80.71003299
84MAPKAPK20.70797515
85MOS0.70428325
86MTOR0.67152331
87BRAF0.66460700
88CAMKK20.64129969
89DAPK30.61707452
90MAP3K30.60866995
91BLK0.60824602
92TGFBR20.60557377
93MAP2K20.60319725
94KDR0.60148157
95RPS6KB20.59957957
96MAP3K70.58932909
97HCK0.57297989
98ERBB20.57228838
99KSR20.57020939
100TAOK10.56592234
101ABL20.56387557
102MAPKAPK50.55019296
103RPS6KA20.54377478
104FGFR30.53650294
105PAK30.53472294
106RPS6KA60.53196885
107CSF1R0.52488034
108BMX0.51884170
109IRAK10.51145147
110PRKG20.50048589
111MST1R0.48124355
112GRK60.47913429
113CDC42BPA0.47328343
114ITK0.45620530
115RIPK40.45114149
116ILK0.44825021
117WNK10.43548823
118EGFR0.42544558
119STK380.41612101
120PDK10.41507849
121SYK0.41468016
122TRPM70.40413241
123PDGFRB0.39104809
124PRKD10.39053145
125KSR10.38928432
126DYRK30.38726425
127SIK30.38560179
128MYLK0.38481049
129MAP3K90.38202255
130OBSCN0.37867581
131LCK0.36946726
132TYRO30.35194276
133MAP3K20.34757701
134GRK70.33251307
135MAP3K50.32031314
136PRKAA10.31857980
137CAMK1G0.31220513
138UHMK10.28795514
139RPS6KA10.27821242
140PRKCH0.27645121

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.62056406
2Lysosome_Homo sapiens_hsa041422.49681484
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.42231021
4Leishmaniasis_Homo sapiens_hsa051402.39215493
5Other glycan degradation_Homo sapiens_hsa005112.10689492
6Legionellosis_Homo sapiens_hsa051341.95108835
7Protein export_Homo sapiens_hsa030601.80601674
8Toxoplasmosis_Homo sapiens_hsa051451.73397398
9Osteoclast differentiation_Homo sapiens_hsa043801.70734598
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69430484
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57737273
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.54141778
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.50779781
14Insulin resistance_Homo sapiens_hsa049311.48567145
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46415711
16Pertussis_Homo sapiens_hsa051331.45982909
17B cell receptor signaling pathway_Homo sapiens_hsa046621.45818521
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41819960
19Tuberculosis_Homo sapiens_hsa051521.40959951
20Amoebiasis_Homo sapiens_hsa051461.40452048
21Shigellosis_Homo sapiens_hsa051311.34411445
22Viral myocarditis_Homo sapiens_hsa054161.33115291
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30626789
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.30191535
25N-Glycan biosynthesis_Homo sapiens_hsa005101.29651117
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.27432955
27TNF signaling pathway_Homo sapiens_hsa046681.27179625
28Influenza A_Homo sapiens_hsa051641.22641793
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21880597
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.21650366
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21497641
32Antigen processing and presentation_Homo sapiens_hsa046121.21124017
33Malaria_Homo sapiens_hsa051441.16916373
34Non-small cell lung cancer_Homo sapiens_hsa052231.16378697
35Phagosome_Homo sapiens_hsa041451.14385810
36Apoptosis_Homo sapiens_hsa042101.14358998
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13708365
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.12827908
39VEGF signaling pathway_Homo sapiens_hsa043701.11509364
40Endometrial cancer_Homo sapiens_hsa052131.10060386
41Chronic myeloid leukemia_Homo sapiens_hsa052201.07042640
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07000028
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01988018
44Salmonella infection_Homo sapiens_hsa051321.00664383
45Measles_Homo sapiens_hsa051621.00324038
46Pentose phosphate pathway_Homo sapiens_hsa000300.99131443
47Type II diabetes mellitus_Homo sapiens_hsa049300.96291004
48Galactose metabolism_Homo sapiens_hsa000520.94687148
49Vibrio cholerae infection_Homo sapiens_hsa051100.94007864
50Thyroid cancer_Homo sapiens_hsa052160.92643042
51Fatty acid degradation_Homo sapiens_hsa000710.90251989
52Type I diabetes mellitus_Homo sapiens_hsa049400.89722335
53Hepatitis B_Homo sapiens_hsa051610.89445743
54Acute myeloid leukemia_Homo sapiens_hsa052210.86631467
55Pancreatic secretion_Homo sapiens_hsa049720.86496638
56ErbB signaling pathway_Homo sapiens_hsa040120.85550621
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84504130
58* Endocytosis_Homo sapiens_hsa041440.83200915
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.82314706
60Bladder cancer_Homo sapiens_hsa052190.81853537
61Small cell lung cancer_Homo sapiens_hsa052220.81222758
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79797183
63GnRH signaling pathway_Homo sapiens_hsa049120.79238129
64Phototransduction_Homo sapiens_hsa047440.79187905
65HIF-1 signaling pathway_Homo sapiens_hsa040660.77395641
66Prolactin signaling pathway_Homo sapiens_hsa049170.77226066
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77079115
68Prostate cancer_Homo sapiens_hsa052150.76832142
69Fatty acid metabolism_Homo sapiens_hsa012120.76143538
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.76084542
71Sphingolipid metabolism_Homo sapiens_hsa006000.75879376
72Sulfur metabolism_Homo sapiens_hsa009200.75702199
73Staphylococcus aureus infection_Homo sapiens_hsa051500.73875834
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73092203
75Fatty acid elongation_Homo sapiens_hsa000620.72715064
76mTOR signaling pathway_Homo sapiens_hsa041500.72010264
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71956683
78Pancreatic cancer_Homo sapiens_hsa052120.71226417
79ABC transporters_Homo sapiens_hsa020100.70438258
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70189102
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70053438
82Estrogen signaling pathway_Homo sapiens_hsa049150.69302830
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67875344
84Graft-versus-host disease_Homo sapiens_hsa053320.66816382
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65967920
86Focal adhesion_Homo sapiens_hsa045100.65478018
87Fructose and mannose metabolism_Homo sapiens_hsa000510.65343771
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65086487
89Hepatitis C_Homo sapiens_hsa051600.64363807
90Herpes simplex infection_Homo sapiens_hsa051680.64062781
91Chemokine signaling pathway_Homo sapiens_hsa040620.63593354
92Proteoglycans in cancer_Homo sapiens_hsa052050.63342960
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63119513
94Prion diseases_Homo sapiens_hsa050200.62591972
95Glioma_Homo sapiens_hsa052140.62574062
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62302392
97Choline metabolism in cancer_Homo sapiens_hsa052310.61138983
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.61072817
99Rheumatoid arthritis_Homo sapiens_hsa053230.60432512
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59855123
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59761109
102Carbon metabolism_Homo sapiens_hsa012000.59672812
103Collecting duct acid secretion_Homo sapiens_hsa049660.59578803
104African trypanosomiasis_Homo sapiens_hsa051430.58840226
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58307877
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58220239
107Notch signaling pathway_Homo sapiens_hsa043300.58061562
108Dilated cardiomyopathy_Homo sapiens_hsa054140.57832589
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56204700
110Renal cell carcinoma_Homo sapiens_hsa052110.55461878
111T cell receptor signaling pathway_Homo sapiens_hsa046600.55295089
112Folate biosynthesis_Homo sapiens_hsa007900.55115918
113Allograft rejection_Homo sapiens_hsa053300.54797215
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.54512503
115Platelet activation_Homo sapiens_hsa046110.53790937
116Renin-angiotensin system_Homo sapiens_hsa046140.53634029
117Insulin signaling pathway_Homo sapiens_hsa049100.51622416
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50652309
119Inositol phosphate metabolism_Homo sapiens_hsa005620.50181121
120Starch and sucrose metabolism_Homo sapiens_hsa005000.49639904
121HTLV-I infection_Homo sapiens_hsa051660.49097323
122AMPK signaling pathway_Homo sapiens_hsa041520.48569500
123Insulin secretion_Homo sapiens_hsa049110.48360856
124Asthma_Homo sapiens_hsa053100.47895954
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47804192
126Viral carcinogenesis_Homo sapiens_hsa052030.47787826
127Adherens junction_Homo sapiens_hsa045200.46994603
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46963170
129Epstein-Barr virus infection_Homo sapiens_hsa051690.45254985
130FoxO signaling pathway_Homo sapiens_hsa040680.43414963

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