VPS37A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.67404504
2central nervous system myelination (GO:0022010)4.67404504
3negative regulation of neurotransmitter secretion (GO:0046929)4.22966078
4fatty acid elongation (GO:0030497)4.00530264
5positive regulation of glycolytic process (GO:0045821)3.87953687
6presynaptic membrane assembly (GO:0097105)3.82450353
7phosphorylated carbohydrate dephosphorylation (GO:0046838)3.76960186
8inositol phosphate dephosphorylation (GO:0046855)3.76960186
9regulation of type B pancreatic cell apoptotic process (GO:2000674)3.63350015
10inositol phosphate catabolic process (GO:0071545)3.61871492
11negative regulation of neurotransmitter transport (GO:0051589)3.53880072
12myelination (GO:0042552)3.49924166
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.48984544
14ensheathment of neurons (GO:0007272)3.47442969
15axon ensheathment (GO:0008366)3.47442969
16positive regulation of protein autophosphorylation (GO:0031954)3.45175352
17presynaptic membrane organization (GO:0097090)3.35931459
18eye photoreceptor cell differentiation (GO:0001754)3.35775692
19photoreceptor cell differentiation (GO:0046530)3.35775692
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.30928770
21regulation of acyl-CoA biosynthetic process (GO:0050812)3.27740806
22L-alpha-amino acid transmembrane transport (GO:1902475)3.18162417
23COPII vesicle coating (GO:0048208)3.15321464
24regulation of cofactor metabolic process (GO:0051193)3.09668643
25regulation of coenzyme metabolic process (GO:0051196)3.09668643
26neuronal action potential propagation (GO:0019227)3.08144854
27intra-Golgi vesicle-mediated transport (GO:0006891)3.07050664
28neuron cell-cell adhesion (GO:0007158)3.06349294
29somite rostral/caudal axis specification (GO:0032525)3.04023013
30polyol catabolic process (GO:0046174)3.02849492
31glycerophospholipid catabolic process (GO:0046475)3.00274863
32negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99854249
33positive regulation of hormone biosynthetic process (GO:0046886)2.99520992
34vascular smooth muscle contraction (GO:0014829)2.97675667
35positive regulation of macroautophagy (GO:0016239)2.96355328
36long-chain fatty acid biosynthetic process (GO:0042759)2.96259315
37transmission of nerve impulse (GO:0019226)2.94370627
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93271981
39signal peptide processing (GO:0006465)2.92956225
40artery smooth muscle contraction (GO:0014824)2.92439969
41lipid particle organization (GO:0034389)2.89309731
42apical protein localization (GO:0045176)2.88707793
43regulation of synaptic vesicle exocytosis (GO:2000300)2.87452597
44regulation of sulfur metabolic process (GO:0042762)2.87155683
45cholesterol biosynthetic process (GO:0006695)2.87135241
46magnesium ion transport (GO:0015693)2.81086593
47zinc ion transmembrane transport (GO:0071577)2.80102121
48asymmetric protein localization (GO:0008105)2.77094703
49protein targeting to Golgi (GO:0000042)2.76733756
50macroautophagy (GO:0016236)2.76030147
51positive regulation of response to extracellular stimulus (GO:0032106)2.75888354
52positive regulation of response to nutrient levels (GO:0032109)2.75888354
53tonic smooth muscle contraction (GO:0014820)2.74342120
54positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.74097154
55response to redox state (GO:0051775)2.73513182
56establishment of protein localization to Golgi (GO:0072600)2.73190474
57regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72577878
58cellular ketone body metabolic process (GO:0046950)2.72318290
59beta-amyloid metabolic process (GO:0050435)2.72074013
60long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.70102818
61detection of calcium ion (GO:0005513)2.69574638
62peptidyl-tyrosine autophosphorylation (GO:0038083)2.66675797
63negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.66217798
64import into cell (GO:0098657)2.64626319
65melanosome transport (GO:0032402)2.63653155
66Golgi to endosome transport (GO:0006895)2.63494279
67positive regulation of actin filament depolymerization (GO:0030836)2.62394664
68retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62218747
69response to methylmercury (GO:0051597)2.60549246
70lactate metabolic process (GO:0006089)2.59477106
71membrane budding (GO:0006900)2.59398168
72regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.59006631
73regulation of glucokinase activity (GO:0033131)2.58442554
74regulation of hexokinase activity (GO:1903299)2.58442554
75water-soluble vitamin biosynthetic process (GO:0042364)2.58025554
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56605572
77L-phenylalanine catabolic process (GO:0006559)2.56605572
78locomotory exploration behavior (GO:0035641)2.56442960
79sequestering of extracellular ligand from receptor (GO:0035581)2.55621439
80oligodendrocyte differentiation (GO:0048709)2.54911695
81regulation of cAMP-dependent protein kinase activity (GO:2000479)2.54428918
82regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54192843
83proline transport (GO:0015824)2.53817431
84negative regulation of neurological system process (GO:0031645)2.53248895
85nodal signaling pathway (GO:0038092)2.53152134
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52944568
87nucleotide transmembrane transport (GO:1901679)2.52089387
88pigment granule transport (GO:0051904)2.51434321
89rhodopsin mediated signaling pathway (GO:0016056)2.50483891
90establishment of melanosome localization (GO:0032401)2.50464036
91single strand break repair (GO:0000012)2.49118027
92sterol biosynthetic process (GO:0016126)2.48612384
93neuronal ion channel clustering (GO:0045161)2.48312753
94peptide hormone secretion (GO:0030072)2.47666436
95peptide secretion (GO:0002790)2.47663360
96creatine metabolic process (GO:0006600)2.47056832
97positive regulation of action potential (GO:0045760)2.47015517
98zinc ion transport (GO:0006829)2.46930252
99oligosaccharide catabolic process (GO:0009313)2.46830716
100regulation of beta-amyloid formation (GO:1902003)2.46777939
101substantia nigra development (GO:0021762)2.46698323
102regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.46657284
103nerve growth factor signaling pathway (GO:0038180)2.46503686
104synaptic vesicle maturation (GO:0016188)2.46247031
105positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46021650
106phospholipid dephosphorylation (GO:0046839)2.45700765
107positive regulation of histone H3-K4 methylation (GO:0051571)2.44795566
108cerebellar granule cell differentiation (GO:0021707)2.44680299
109synaptic vesicle exocytosis (GO:0016079)2.44460747
110ER to Golgi vesicle-mediated transport (GO:0006888)2.44419071
111regulation of steroid hormone biosynthetic process (GO:0090030)2.44333825
112endocrine pancreas development (GO:0031018)2.42797495
113fatty-acyl-CoA biosynthetic process (GO:0046949)2.42796901
114branched-chain amino acid catabolic process (GO:0009083)2.41893652
115peptidyl-cysteine modification (GO:0018198)2.41479651
116dendrite morphogenesis (GO:0048813)2.40620703
117regulation of amyloid precursor protein catabolic process (GO:1902991)2.40535057
118regulation of glycolytic process (GO:0006110)2.40186763
119gamma-aminobutyric acid signaling pathway (GO:0007214)2.40155265
120cellular response to hepatocyte growth factor stimulus (GO:0035729)2.39774711
121response to hepatocyte growth factor (GO:0035728)2.39774711
122establishment of pigment granule localization (GO:0051905)2.39349895
123calcium ion import (GO:0070509)2.38950744
124cellular zinc ion homeostasis (GO:0006882)2.38778962
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.37401876
126ER overload response (GO:0006983)2.37338846
127long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.33775134
128early endosome to late endosome transport (GO:0045022)2.33324627
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.31778085
130neurotransmitter catabolic process (GO:0042135)2.31645821
131regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.31028485
132negative regulation of JUN kinase activity (GO:0043508)2.30762862
133regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.30466460
134regulation of synaptic vesicle transport (GO:1902803)2.30014086
135detection of light stimulus involved in visual perception (GO:0050908)2.29783955
136detection of light stimulus involved in sensory perception (GO:0050962)2.29783955
137gamma-aminobutyric acid transport (GO:0015812)2.29401873
138L-amino acid import (GO:0043092)2.29388666
139vesicle transport along microtubule (GO:0047496)2.29223064
140adhesion of symbiont to host cell (GO:0044650)2.29026374
141virion attachment to host cell (GO:0019062)2.29026374
142regulation of protein glycosylation (GO:0060049)2.28998104
143positive regulation of mitochondrial fission (GO:0090141)2.27965646
144ketone body metabolic process (GO:1902224)2.27952928
145photoreceptor cell maintenance (GO:0045494)2.27450715
146positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.27220237
147positive regulation of insulin secretion (GO:0032024)2.27048843
148ether lipid metabolic process (GO:0046485)2.26794821
149regulation of vesicle fusion (GO:0031338)2.26326696
150phosphatidylinositol dephosphorylation (GO:0046856)2.25529186
151negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.24951041
152Golgi to plasma membrane protein transport (GO:0043001)2.24498147
153glutamate secretion (GO:0014047)2.24077641
154endoplasmic reticulum organization (GO:0007029)2.23920669
155type B pancreatic cell development (GO:0003323)2.22455152
156regulation of catecholamine metabolic process (GO:0042069)2.21814262
157regulation of dopamine metabolic process (GO:0042053)2.21814262
158regulation of Rac protein signal transduction (GO:0035020)2.21598094
159protein localization to Golgi apparatus (GO:0034067)2.21323829
160negative regulation of hormone biosynthetic process (GO:0032353)2.21287796
161interkinetic nuclear migration (GO:0022027)2.20838620
162acrosome assembly (GO:0001675)2.20288421
163regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.20054534
164positive regulation of hormone metabolic process (GO:0032352)2.19754943
165neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.19679190
166response to lipoprotein particle (GO:0055094)2.19557280
167dopamine transport (GO:0015872)2.19192079
168positive regulation of cellular amine metabolic process (GO:0033240)2.19159042
169nitric oxide biosynthetic process (GO:0006809)2.17988759
170response to pheromone (GO:0019236)2.17719464
171positive regulation of autophagy (GO:0010508)2.16846423
172protein palmitoylation (GO:0018345)2.16723021
173negative regulation of inclusion body assembly (GO:0090084)2.16574784
174chemosensory behavior (GO:0007635)2.16396911
175positive regulation of membrane potential (GO:0045838)2.16194919
176negative regulation of activin receptor signaling pathway (GO:0032926)2.15613844
177dopamine biosynthetic process (GO:0042416)2.15478895
178neuron recognition (GO:0008038)2.15162673
179positive regulation of sodium ion transmembrane transport (GO:1902307)2.13967289
180neuron remodeling (GO:0016322)2.13576313
181positive regulation of potassium ion transport (GO:0043268)2.11749879
182fatty-acyl-CoA metabolic process (GO:0035337)2.11620187
183regulation of collateral sprouting (GO:0048670)2.11294507
184mating behavior (GO:0007617)2.10417127
185insulin secretion (GO:0030073)2.08755461
186peptide hormone processing (GO:0016486)2.08268298
187protein localization to synapse (GO:0035418)2.08078587
188negative regulation of synaptic transmission (GO:0050805)2.06880984
189cyclic nucleotide catabolic process (GO:0009214)2.06761846
190long-term synaptic potentiation (GO:0060291)2.06460153
191neuron-neuron synaptic transmission (GO:0007270)2.06139715
192response to dietary excess (GO:0002021)2.05965683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.35184105
2EZH2_22144423_ChIP-Seq_EOC_Human2.36665668
3TAF15_26573619_Chip-Seq_HEK293_Human2.35709402
4WT1_19549856_ChIP-ChIP_CCG9911_Human2.32772812
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.30434377
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11703594
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09119769
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03223539
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01080830
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00852782
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95516587
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90527264
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88770218
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87325850
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81822309
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.80606860
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79495269
18* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.77904469
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77019405
20EZH2_27294783_Chip-Seq_NPCs_Mouse1.76963248
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75376410
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74287690
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73179210
24EWS_26573619_Chip-Seq_HEK293_Human1.72976826
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70690643
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70553854
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70242723
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68825143
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.65664854
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.65287969
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64321081
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63920662
33P300_19829295_ChIP-Seq_ESCs_Human1.62212748
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59689960
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59689960
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59051052
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58714419
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57834127
39REST_21632747_ChIP-Seq_MESCs_Mouse1.57353618
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57131806
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56681367
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56116365
43SMAD4_21799915_ChIP-Seq_A2780_Human1.55824225
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.54705318
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52052822
46* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50958826
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.50897783
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.49319686
49CBP_20019798_ChIP-Seq_JUKART_Human1.48212454
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48212454
51DROSHA_22980978_ChIP-Seq_HELA_Human1.47029604
52* STAT3_23295773_ChIP-Seq_U87_Human1.46711355
53ER_23166858_ChIP-Seq_MCF-7_Human1.46188885
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.45570345
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42787914
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42507614
57VDR_22108803_ChIP-Seq_LS180_Human1.41154822
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40756713
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39713100
60FUS_26573619_Chip-Seq_HEK293_Human1.39248154
61CDX2_22108803_ChIP-Seq_LS180_Human1.37389268
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37303985
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.36413079
64AR_21572438_ChIP-Seq_LNCaP_Human1.35694810
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35255169
66IGF1R_20145208_ChIP-Seq_DFB_Human1.35085855
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33773051
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33246267
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.32904730
70BRD4_25478319_ChIP-Seq_HGPS_Human1.32672171
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32456511
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.31922416
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30372656
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30358377
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30358377
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.29727025
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28218048
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27622741
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27315993
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26823359
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.25144772
82ZNF274_21170338_ChIP-Seq_K562_Hela1.24434512
83CJUN_26792858_Chip-Seq_BT549_Human1.23255802
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.22749020
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.21796360
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21627509
87TCF4_23295773_ChIP-Seq_U87_Human1.20949591
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20793564
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20740204
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.19396064
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.18993143
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18820069
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18263649
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.17583250
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17173117
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16875173
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16002924
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.14296284
99ELK1_19687146_ChIP-ChIP_HELA_Human1.13925259
100AR_25329375_ChIP-Seq_VCAP_Human1.13328977
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.13024680
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12095632
103SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11906330
104RUNX2_22187159_ChIP-Seq_PCA_Human1.10353355
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09335750
106NANOG_19829295_ChIP-Seq_ESCs_Human1.08981329
107SOX2_19829295_ChIP-Seq_ESCs_Human1.08981329
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08472740
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.08408901
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08349176
111TCF4_22108803_ChIP-Seq_LS180_Human1.08339525
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08131078
113P53_22387025_ChIP-Seq_ESCs_Mouse1.07381660
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.07276409
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07149142
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07119107
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.07046820
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05220410
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.04623970
120CTCF_18555785_Chip-Seq_ESCs_Mouse1.04378565
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04357643
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04145137
123AHR_22903824_ChIP-Seq_MCF-7_Human1.03855680
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03793912
125JUN_21703547_ChIP-Seq_K562_Human1.02821244
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02216057
127P300_18555785_Chip-Seq_ESCs_Mouse1.00710027
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00584865
129TAL1_26923725_Chip-Seq_HPCs_Mouse1.00552274
130HTT_18923047_ChIP-ChIP_STHdh_Human1.00424655
131BCAT_22108803_ChIP-Seq_LS180_Human1.00153149
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99351306
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99351306
134TP53_18474530_ChIP-ChIP_U2OS_Human0.99140385
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98884023
136STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98634003
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97977827
138SOX2_18555785_Chip-Seq_ESCs_Mouse0.97884927
139TP53_16413492_ChIP-PET_HCT116_Human0.97797186
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.97727059
141AR_19668381_ChIP-Seq_PC3_Human0.97615658
142RNF2_27304074_Chip-Seq_NSC_Mouse0.97579100
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96824056
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96674124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.32457568
2MP0003195_calcinosis3.09029363
3MP0003880_abnormal_central_pattern2.94684923
4MP0003890_abnormal_embryonic-extraembry2.84519492
5MP0006054_spinal_hemorrhage2.73344327
6MP0010234_abnormal_vibrissa_follicle2.62792619
7MP0005551_abnormal_eye_electrophysiolog2.58570533
8MP0000920_abnormal_myelination2.55854702
9MP0004859_abnormal_synaptic_plasticity2.54080493
10MP0004215_abnormal_myocardial_fiber2.29434727
11MP0004043_abnormal_pH_regulation2.27347389
12MP0003690_abnormal_glial_cell2.24062987
13MP0000013_abnormal_adipose_tissue2.23128744
14MP0001486_abnormal_startle_reflex2.22488593
15MP0009780_abnormal_chondrocyte_physiolo2.21901666
16MP0002064_seizures2.20604879
17MP0003635_abnormal_synaptic_transmissio2.19814365
18MP0002272_abnormal_nervous_system2.16697775
19MP0002139_abnormal_hepatobiliary_system2.13417213
20MP0008877_abnormal_DNA_methylation2.10625447
21MP0003329_amyloid_beta_deposits2.09308332
22MP0009745_abnormal_behavioral_response2.05767732
23MP0004885_abnormal_endolymph2.00252483
24MP0006072_abnormal_retinal_apoptosis1.99948260
25MP0009046_muscle_twitch1.94918408
26MP0003941_abnormal_skin_development1.88568348
27MP0002734_abnormal_mechanical_nocicepti1.88201694
28MP0002572_abnormal_emotion/affect_behav1.81876247
29MP0004484_altered_response_of1.78543114
30MP0004084_abnormal_cardiac_muscle1.77925899
31MP0005253_abnormal_eye_physiology1.77487104
32MP0004510_myositis1.73877302
33MP0000372_irregular_coat_pigmentation1.73628799
34MP0002229_neurodegeneration1.73105892
35MP0002063_abnormal_learning/memory/cond1.70985603
36MP0004742_abnormal_vestibular_system1.70598853
37MP0000778_abnormal_nervous_system1.68293190
38MP0003183_abnormal_peptide_metabolism1.67142038
39MP0010352_gastrointestinal_tract_polyps1.65268316
40MP0001440_abnormal_grooming_behavior1.62536833
41MP0005379_endocrine/exocrine_gland_phen1.59326159
42MP0000569_abnormal_digit_pigmentation1.56587110
43MP0008775_abnormal_heart_ventricle1.53669519
44MP0003634_abnormal_glial_cell1.53188268
45MP0001984_abnormal_olfaction1.50030622
46MP0002909_abnormal_adrenal_gland1.49902469
47MP0010386_abnormal_urinary_bladder1.48570844
48MP0001501_abnormal_sleep_pattern1.47337181
49MP0003868_abnormal_feces_composition1.47248743
50MP0005645_abnormal_hypothalamus_physiol1.44966689
51MP0003787_abnormal_imprinting1.43918490
52MP0004145_abnormal_muscle_electrophysio1.43227625
53MP0003718_maternal_effect1.42648403
54MP0005646_abnormal_pituitary_gland1.41689148
55MP0001905_abnormal_dopamine_level1.40830923
56MP0002067_abnormal_sensory_capabilities1.40325068
57MP0001529_abnormal_vocalization1.40292609
58MP0005187_abnormal_penis_morphology1.39142664
59MP0001502_abnormal_circadian_rhythm1.38712248
60MP0000427_abnormal_hair_cycle1.38044057
61MP0003121_genomic_imprinting1.36464431
62MP0004134_abnormal_chest_morphology1.36090883
63MP0005365_abnormal_bile_salt1.32645075
64MP0002733_abnormal_thermal_nociception1.32191413
65MP0005084_abnormal_gallbladder_morpholo1.28481193
66MP0002090_abnormal_vision1.28294452
67MP0001485_abnormal_pinna_reflex1.27718161
68MP0002332_abnormal_exercise_endurance1.27638614
69MP0003950_abnormal_plasma_membrane1.27452726
70MP0002882_abnormal_neuron_morphology1.26747822
71MP0002693_abnormal_pancreas_physiology1.26391639
72MP0004924_abnormal_behavior1.24706796
73MP0005386_behavior/neurological_phenoty1.24706796
74MP0004036_abnormal_muscle_relaxation1.23277100
75MP0010329_abnormal_lipoprotein_level1.22536445
76MP0005423_abnormal_somatic_nervous1.22416976
77MP0008438_abnormal_cutaneous_collagen1.22077811
78MP0009697_abnormal_copulation1.21793803
79MP0005085_abnormal_gallbladder_physiolo1.21650601
80MP0002877_abnormal_melanocyte_morpholog1.21130690
81MP0000462_abnormal_digestive_system1.20259145
82MP0001944_abnormal_pancreas_morphology1.19145177
83MP0005171_absent_coat_pigmentation1.18298605
84MP0002254_reproductive_system_inflammat1.18267444
85MP0001970_abnormal_pain_threshold1.18227726
86MP0001299_abnormal_eye_distance/1.16957460
87MP0004019_abnormal_vitamin_homeostasis1.16181809
88MP0005535_abnormal_body_temperature1.16125495
89MP0008057_abnormal_DNA_replication1.15721570
90MP0000604_amyloidosis1.13856948
91MP0003632_abnormal_nervous_system1.13687725
92MP0003656_abnormal_erythrocyte_physiolo1.13059037
93MP0003633_abnormal_nervous_system1.12428184
94MP0002972_abnormal_cardiac_muscle1.11907135
95MP0000955_abnormal_spinal_cord1.11679796
96MP0006276_abnormal_autonomic_nervous1.10870502
97MP0005332_abnormal_amino_acid1.10850817
98MP0000003_abnormal_adipose_tissue1.10193091
99MP0000639_abnormal_adrenal_gland1.09989764
100MP0004142_abnormal_muscle_tone1.08837139
101MP0001661_extended_life_span1.08629144
102MP0005195_abnormal_posterior_eye1.08389322
103MP0008875_abnormal_xenobiotic_pharmacok1.08042613
104MP0010678_abnormal_skin_adnexa1.07002194
105MP0003123_paternal_imprinting1.06979983
106MP0002066_abnormal_motor_capabilities/c1.05590063
107MP0004147_increased_porphyrin_level1.05522970
108MP0008569_lethality_at_weaning1.05088268
109MP0002557_abnormal_social/conspecific_i1.03492634
110MP0004085_abnormal_heartbeat1.03067173
111MP0005620_abnormal_muscle_contractility1.00847017
112MP0002078_abnormal_glucose_homeostasis1.00016826
113MP0001968_abnormal_touch/_nociception0.99808725
114MP0003631_nervous_system_phenotype0.98652393
115MP0002295_abnormal_pulmonary_circulatio0.98050924
116MP0003122_maternal_imprinting0.96765143
117MP0003252_abnormal_bile_duct0.95835531
118MP0002735_abnormal_chemical_nociception0.95621384
119MP0005075_abnormal_melanosome_morpholog0.94996298
120MP0002752_abnormal_somatic_nervous0.90746371
121MP0002876_abnormal_thyroid_physiology0.90266193
122MP0002638_abnormal_pupillary_reflex0.88980322
123MP0001756_abnormal_urination0.88661277
124MP0001666_abnormal_nutrient_absorption0.87002240
125MP0001324_abnormal_eye_pigmentation0.86798030
126MP0003186_abnormal_redox_activity0.86087853
127MP0002837_dystrophic_cardiac_calcinosis0.85763470
128MP0010368_abnormal_lymphatic_system0.85688299
129MP0006036_abnormal_mitochondrial_physio0.85400032
130MP0002118_abnormal_lipid_homeostasis0.85352191
131MP0005220_abnormal_exocrine_pancreas0.84496104
132MP0002184_abnormal_innervation0.84098528
133MP0001177_atelectasis0.83339552
134MP0003011_delayed_dark_adaptation0.82933489
135MP0000358_abnormal_cell_content/0.82706881
136MP0003283_abnormal_digestive_organ0.82337921
137MP0005367_renal/urinary_system_phenotyp0.82133160
138MP0000516_abnormal_urinary_system0.82133160
139MP0003172_abnormal_lysosome_physiology0.80685402
140MP0001986_abnormal_taste_sensitivity0.80266274
141MP0002106_abnormal_muscle_physiology0.79876344
142MP0004272_abnormal_basement_membrane0.79808755
143MP0001963_abnormal_hearing_physiology0.79389207
144MP0002822_catalepsy0.79382724
145MP0002269_muscular_atrophy0.78605813
146MP0005395_other_phenotype0.77577523
147MP0001346_abnormal_lacrimal_gland0.77123942
148MP0001542_abnormal_bone_strength0.77027000
149MP0004233_abnormal_muscle_weight0.75893007
150MP0005165_increased_susceptibility_to0.75787234
151MP0005248_abnormal_Harderian_gland0.75353221
152MP0008004_abnormal_stomach_pH0.75271517
153MP0001188_hyperpigmentation0.74684070
154MP0000631_abnormal_neuroendocrine_gland0.74677539
155MP0006035_abnormal_mitochondrial_morpho0.74302791
156MP0002163_abnormal_gland_morphology0.72718927
157MP0005409_darkened_coat_color0.72075425
158MP0003221_abnormal_cardiomyocyte_apopto0.71436225
159MP0000230_abnormal_systemic_arterial0.71413986
160MP0002938_white_spotting0.71195059
161MP0000747_muscle_weakness0.70090196

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.22849485
2Focal motor seizures (HP:0011153)3.66027146
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.57164830
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.57164830
5Abnormality of macular pigmentation (HP:0008002)3.54711362
6Proximal tubulopathy (HP:0000114)3.51031836
7Hyperinsulinemic hypoglycemia (HP:0000825)3.44225647
8Sensory axonal neuropathy (HP:0003390)3.40050075
9Hypothermia (HP:0002045)3.37780127
10Atonic seizures (HP:0010819)3.25939225
11Cerebral inclusion bodies (HP:0100314)3.19570510
12Hypoglycemic seizures (HP:0002173)3.01298818
13Central scotoma (HP:0000603)3.00025140
14Dyschromatopsia (HP:0007641)2.99055471
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.95764213
16Abnormality of the corticospinal tract (HP:0002492)2.95224437
17Tetraparesis (HP:0002273)2.92500223
18Parakeratosis (HP:0001036)2.87519202
19Pheochromocytoma (HP:0002666)2.86999155
20Akinesia (HP:0002304)2.82411897
21Intention tremor (HP:0002080)2.80287868
22Papillary thyroid carcinoma (HP:0002895)2.78622463
23Hyperventilation (HP:0002883)2.77613685
24Thyroid carcinoma (HP:0002890)2.73395807
25Symptomatic seizures (HP:0011145)2.67135665
26Supranuclear gaze palsy (HP:0000605)2.62962605
27Congenital stationary night blindness (HP:0007642)2.62762512
28Spastic gait (HP:0002064)2.60720203
29Dysmetria (HP:0001310)2.60506129
30Focal seizures (HP:0007359)2.59697750
31Increased circulating renin level (HP:0000848)2.58913266
32Scanning speech (HP:0002168)2.56084935
33Intestinal atresia (HP:0011100)2.53356246
34Bundle branch block (HP:0011710)2.51337256
35Decreased central vision (HP:0007663)2.50942633
36Intrahepatic cholestasis (HP:0001406)2.50292904
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.47309436
38Epileptic encephalopathy (HP:0200134)2.46630857
39Blue irides (HP:0000635)2.44368829
40Neuroendocrine neoplasm (HP:0100634)2.43753671
41Slow saccadic eye movements (HP:0000514)2.37154091
42Absence seizures (HP:0002121)2.35556897
43Retinal atrophy (HP:0001105)2.34216484
44Dialeptic seizures (HP:0011146)2.34177923
45Palpitations (HP:0001962)2.33937940
46Prolonged partial thromboplastin time (HP:0003645)2.33209855
47Insulin-resistant diabetes mellitus (HP:0000831)2.33123213
48Abolished electroretinogram (ERG) (HP:0000550)2.31553354
49Peripheral hypomyelination (HP:0007182)2.27568937
50Generalized aminoaciduria (HP:0002909)2.26318937
51Hypoplasia of the fovea (HP:0007750)2.26014784
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.26014784
53Visual hallucinations (HP:0002367)2.25750126
54Action tremor (HP:0002345)2.25576932
55Delayed gross motor development (HP:0002194)2.24812476
56Scotoma (HP:0000575)2.24395910
57Nemaline bodies (HP:0003798)2.23586422
58Dysdiadochokinesis (HP:0002075)2.22019464
59Conjugated hyperbilirubinemia (HP:0002908)2.21767806
60Cerebral hemorrhage (HP:0001342)2.20594255
61Vaginal atresia (HP:0000148)2.19101518
62Nephrogenic diabetes insipidus (HP:0009806)2.18070054
63Bony spicule pigmentary retinopathy (HP:0007737)2.17555502
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.17030807
65Exercise-induced muscle cramps (HP:0003710)2.16167727
66Epileptiform EEG discharges (HP:0011182)2.15453434
67EEG with generalized epileptiform discharges (HP:0011198)2.14700349
68Muscle fiber inclusion bodies (HP:0100299)2.14504450
69Abnormality of calcium-phosphate metabolism (HP:0100530)2.14079166
70Cardiovascular calcification (HP:0011915)2.14049729
71Progressive cerebellar ataxia (HP:0002073)2.13903674
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.13566918
73Genital tract atresia (HP:0001827)2.12346258
74Abnormality of vitamin B metabolism (HP:0004340)2.10685647
75Methylmalonic acidemia (HP:0002912)2.07809974
76Short tibia (HP:0005736)2.07418101
77Generalized tonic-clonic seizures (HP:0002069)2.05286693
78Hypsarrhythmia (HP:0002521)2.03960439
79Renal cortical cysts (HP:0000803)2.03800383
80Double outlet right ventricle (HP:0001719)2.03148449
81Congenital malformation of the right heart (HP:0011723)2.03148449
82Ketoacidosis (HP:0001993)2.02186571
83Enlarged penis (HP:0000040)2.02130572
84Abnormality of the fovea (HP:0000493)2.02034809
85Abnormality of the pancreatic islet cells (HP:0006476)2.01811426
86Abnormality of endocrine pancreas physiology (HP:0012093)2.01811426
87Vascular calcification (HP:0004934)2.01476591
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00940673
89Abnormality of alanine metabolism (HP:0010916)2.00940673
90Hyperalaninemia (HP:0003348)2.00940673
91Anteriorly placed anus (HP:0001545)2.00186617
92Congenital sensorineural hearing impairment (HP:0008527)1.98663206
93Orthostatic hypotension (HP:0001278)1.98482627
94Gaze-evoked nystagmus (HP:0000640)1.98355188
95Metaphyseal dysplasia (HP:0100255)1.98059452
96Cone-rod dystrophy (HP:0000548)1.97187837
97Clumsiness (HP:0002312)1.96715551
98Febrile seizures (HP:0002373)1.96433931
99Hypophosphatemic rickets (HP:0004912)1.95239758
100Excessive salivation (HP:0003781)1.94930175
101Drooling (HP:0002307)1.94930175
102Hypoglycemic coma (HP:0001325)1.94374232
103Volvulus (HP:0002580)1.94110502
104Hyperglycemia (HP:0003074)1.93756513
105Increased CSF protein (HP:0002922)1.93665193
106Gait imbalance (HP:0002141)1.92729340
107Anxiety (HP:0000739)1.91478389
108Abnormality of urine glucose concentration (HP:0011016)1.91190395
109Glycosuria (HP:0003076)1.91190395
110Widely spaced teeth (HP:0000687)1.90803638
111Autoamputation (HP:0001218)1.90204653
112Generalized myoclonic seizures (HP:0002123)1.89654538
113Abnormality of the intrinsic pathway (HP:0010989)1.89523849
114Broad-based gait (HP:0002136)1.87184391
115Abnormal rod and cone electroretinograms (HP:0008323)1.87013657
116Thickened helices (HP:0000391)1.86790531
117Poor speech (HP:0002465)1.86654503
118Medial flaring of the eyebrow (HP:0010747)1.86495132
119Progressive neurologic deterioration (HP:0002344)1.86373985
120Abnormality of vitamin metabolism (HP:0100508)1.84425729
121Hemiparesis (HP:0001269)1.84034107
122Progressive macrocephaly (HP:0004481)1.83982649
123Hyperlipoproteinemia (HP:0010980)1.83386509
124Onion bulb formation (HP:0003383)1.83377902
125Postural tremor (HP:0002174)1.82720814
126Agitation (HP:0000713)1.82650863
127Disproportionate short-trunk short stature (HP:0003521)1.81941230
128Hyperkalemia (HP:0002153)1.81141253
129Abnormality of the calf musculature (HP:0001430)1.81019496
130Albinism (HP:0001022)1.80493945
131Retinal dysplasia (HP:0007973)1.80063680
132Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79942334
133Hypomagnesemia (HP:0002917)1.79871284
134Myokymia (HP:0002411)1.78909452
135Cupped ear (HP:0000378)1.78052308
136Spastic paraparesis (HP:0002313)1.77768340
137Muscular hypotonia of the trunk (HP:0008936)1.77198171
138Retinitis pigmentosa (HP:0000510)1.77176252
139Type II lissencephaly (HP:0007260)1.77167061
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.76711365
141Absent/shortened dynein arms (HP:0200106)1.76711365
142Congenital primary aphakia (HP:0007707)1.76079234
143Abnormal ciliary motility (HP:0012262)1.75728514
144Left ventricular hypertrophy (HP:0001712)1.75388614
145Hydroxyprolinuria (HP:0003080)1.75200778
146Abnormality of proline metabolism (HP:0010907)1.75200778
147Hypokalemia (HP:0002900)1.74667112
148Abnormality of polysaccharide metabolism (HP:0011012)1.73657142
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73657142
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73657142
151Abnormality of potassium homeostasis (HP:0011042)1.73587645
152Hematochezia (HP:0002573)1.72345862
153Attenuation of retinal blood vessels (HP:0007843)1.71615195
154Hand muscle atrophy (HP:0009130)1.71515048
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71051691
156Insidious onset (HP:0003587)1.70739773
157Termporal pattern (HP:0011008)1.70739773
158Abnormality of the common coagulation pathway (HP:0010990)1.69225713
159Ketosis (HP:0001946)1.69049709
1603-Methylglutaconic aciduria (HP:0003535)1.66885401
161Mucopolysacchariduria (HP:0008155)1.66757732
162Urinary glycosaminoglycan excretion (HP:0003541)1.66757732
163Progressive inability to walk (HP:0002505)1.66370071
164Fair hair (HP:0002286)1.66328390
165Gonadotropin excess (HP:0000837)1.64780046
166Abnormality of abdominal situs (HP:0011620)1.64439999
167Abdominal situs inversus (HP:0003363)1.64439999
168Cutaneous melanoma (HP:0012056)1.64428414
169Abnormality of the renal cortex (HP:0011035)1.61447066
170Neoplasm of the thyroid gland (HP:0100031)1.60951423
171Syncope (HP:0001279)1.59000275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.23873701
2TNIK3.17236948
3INSRR2.97720626
4OXSR12.91173897
5ACVR1B2.74546640
6MAP3K122.65938528
7WNK42.34693080
8ERBB32.30669465
9MAPK152.28422476
10TRIM282.27218220
11BCR2.23316582
12CASK2.23177102
13STK242.07541205
14NTRK32.07368587
15EPHA42.00965233
16EIF2AK32.00633598
17STK161.91923256
18MAP3K21.90414955
19PNCK1.89228672
20STK38L1.82900452
21WNK11.82578889
22OBSCN1.79531081
23WNK31.77292851
24NTRK11.70366959
25IRAK21.64196918
26STK31.63428536
27MYLK1.62553557
28FGFR21.56629941
29PKN11.54533665
30EPHB11.54422692
31TRPM71.51778390
32NEK61.51278407
33AKT31.50754374
34UHMK11.50087132
35PAK61.32814254
36IRAK11.32117678
37MAP3K41.32072990
38PRPF4B1.29567173
39FRK1.29081096
40LIMK11.25377733
41MET1.22908432
42SGK2231.22567238
43SGK4941.22567238
44TAOK31.20420097
45FLT31.19586343
46MAPK131.19383451
47NLK1.17871485
48MARK11.16896444
49MAP4K21.16859996
50CAMKK21.16433886
51CSNK1A1L1.15708254
52PAK31.15440188
53CSNK1G21.14000476
54ARAF1.11038694
55ICK1.09100033
56MAP3K131.07431767
57MAP3K51.06236732
58NUAK11.04164777
59CAMK2D0.99856489
60MST40.98252415
61CAMK2B0.98165286
62CSNK1G30.97832147
63LATS10.95938369
64TYRO30.95787829
65MAP2K70.93877162
66CDK50.93733262
67CSNK1G10.93507781
68PHKG10.92109436
69PHKG20.92109436
70MUSK0.90881022
71HIPK20.90159457
72CAMK2A0.88299375
73MAP2K40.87440892
74PRKCE0.86731851
75GRK10.84562409
76MAP3K90.78863814
77NEK10.75696052
78KSR20.73723350
79PINK10.72354677
80MINK10.70550660
81ERBB40.70446976
82MKNK20.69519296
83FGR0.69193186
84PRKD30.68336464
85PDK20.68279553
86STK110.67339276
87MARK20.66823195
88PLK20.65497512
89PTK20.65016161
90PDPK10.64270989
91PIK3CG0.64206494
92CAMK2G0.62751353
93NTRK20.62730286
94SGK10.62692399
95TESK10.62262640
96PRKCQ0.61752377
97SGK20.61635428
98YES10.61434101
99CAMK1G0.60943567
100PIM20.60346593
101CDK30.60185358
102SCYL20.59952958
103BMPR20.58276877
104PBK0.58098342
105PRKCG0.57917216
106BMPR1B0.57870111
107PRKCH0.57571128
108ROCK20.56189428
109BRSK20.54398164
110CDK190.54094430
111MOS0.53136500
112BRAF0.53077719
113PRKAA20.52360592
114FER0.52320267
115PRKG10.51086679
116DAPK20.49693036
117MAPKAPK50.49504172
118GRK50.49421429
119KSR10.49001812
120CSNK1A10.48855233
121EPHA30.47881560
122RET0.47616556
123ADRBK20.47541119
124PTK2B0.47294321
125FGFR30.46295444
126PRKACA0.45970229
127FES0.45864946
128PLK30.45384958
129PRKD20.44647643
130MAP3K60.43729112
131MAP3K10.43212013
132PIK3CA0.43200712
133PRKACB0.42638402
134GRK70.42554032
135CSNK1D0.42006761
136PRKAA10.37108442
137DAPK10.36889530
138TGFBR10.34816645
139NEK90.34304151
140CSNK1E0.33415998
141EGFR0.33209089
142BCKDK0.32854922
143CDK60.31562859
144GSK3A0.30959443
145RAF10.26368528

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.07774990
2Phototransduction_Homo sapiens_hsa047442.59792310
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54306251
4Sulfur metabolism_Homo sapiens_hsa009202.35752933
5Steroid biosynthesis_Homo sapiens_hsa001002.30806863
6Fatty acid elongation_Homo sapiens_hsa000622.10697249
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10146857
8GABAergic synapse_Homo sapiens_hsa047271.85226139
9Insulin secretion_Homo sapiens_hsa049111.82639135
10Protein export_Homo sapiens_hsa030601.70532477
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69522120
12Synaptic vesicle cycle_Homo sapiens_hsa047211.60588303
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59423747
14Nicotine addiction_Homo sapiens_hsa050331.58870717
15Butanoate metabolism_Homo sapiens_hsa006501.57396477
16Serotonergic synapse_Homo sapiens_hsa047261.55827493
17Glutamatergic synapse_Homo sapiens_hsa047241.54860780
18Nitrogen metabolism_Homo sapiens_hsa009101.50509892
19Selenocompound metabolism_Homo sapiens_hsa004501.47281202
20Collecting duct acid secretion_Homo sapiens_hsa049661.43588486
21Morphine addiction_Homo sapiens_hsa050321.43137568
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42554213
23Ether lipid metabolism_Homo sapiens_hsa005651.38954036
24Vibrio cholerae infection_Homo sapiens_hsa051101.35736475
25Amphetamine addiction_Homo sapiens_hsa050311.35563796
26Long-term potentiation_Homo sapiens_hsa047201.31446238
27Circadian entrainment_Homo sapiens_hsa047131.30091552
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26774242
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25630273
30Cocaine addiction_Homo sapiens_hsa050301.24846644
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21443781
32Dopaminergic synapse_Homo sapiens_hsa047281.19918383
33Long-term depression_Homo sapiens_hsa047301.17876151
34Axon guidance_Homo sapiens_hsa043601.17468277
35Type II diabetes mellitus_Homo sapiens_hsa049301.16574996
36Taste transduction_Homo sapiens_hsa047421.16116664
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.16065500
38Cholinergic synapse_Homo sapiens_hsa047251.14188322
39Sphingolipid metabolism_Homo sapiens_hsa006001.11810731
40Basal transcription factors_Homo sapiens_hsa030221.10920042
41Folate biosynthesis_Homo sapiens_hsa007901.07695431
42Olfactory transduction_Homo sapiens_hsa047401.03763047
43Histidine metabolism_Homo sapiens_hsa003401.02513498
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.00036247
45Renin secretion_Homo sapiens_hsa049240.99172849
46Salivary secretion_Homo sapiens_hsa049700.97025214
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95187263
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94577350
49Fatty acid metabolism_Homo sapiens_hsa012120.91244693
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90692437
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89813716
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87334047
53Ovarian steroidogenesis_Homo sapiens_hsa049130.86222901
54Pancreatic secretion_Homo sapiens_hsa049720.86087782
55Gastric acid secretion_Homo sapiens_hsa049710.85216822
56Circadian rhythm_Homo sapiens_hsa047100.84108923
57Dorso-ventral axis formation_Homo sapiens_hsa043200.83841435
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83414715
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83155538
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82055639
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81674142
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81076887
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81056548
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.80334654
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79547977
66ABC transporters_Homo sapiens_hsa020100.79182848
67Peroxisome_Homo sapiens_hsa041460.76248451
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75798709
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75378996
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73339900
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73134596
72Non-homologous end-joining_Homo sapiens_hsa034500.72951065
73Starch and sucrose metabolism_Homo sapiens_hsa005000.72946917
74Caffeine metabolism_Homo sapiens_hsa002320.72321882
75Linoleic acid metabolism_Homo sapiens_hsa005910.70723282
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70685412
77Inositol phosphate metabolism_Homo sapiens_hsa005620.69741045
78Oxytocin signaling pathway_Homo sapiens_hsa049210.69473076
79Tryptophan metabolism_Homo sapiens_hsa003800.67003687
80cAMP signaling pathway_Homo sapiens_hsa040240.65842049
81Oxidative phosphorylation_Homo sapiens_hsa001900.65299865
82Oocyte meiosis_Homo sapiens_hsa041140.65285529
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64462157
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63708617
85Bile secretion_Homo sapiens_hsa049760.63444410
86Glutathione metabolism_Homo sapiens_hsa004800.63351275
87Calcium signaling pathway_Homo sapiens_hsa040200.62934270
88Arginine biosynthesis_Homo sapiens_hsa002200.62903563
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62365970
90Prion diseases_Homo sapiens_hsa050200.61416363
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.61356992
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61244665
93Renal cell carcinoma_Homo sapiens_hsa052110.61229334
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60571080
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58444586
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57743590
97ErbB signaling pathway_Homo sapiens_hsa040120.57716531
98Lysosome_Homo sapiens_hsa041420.57403492
99Thyroid hormone synthesis_Homo sapiens_hsa049180.56998455
100Type I diabetes mellitus_Homo sapiens_hsa049400.56707314
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.56483306
102Rheumatoid arthritis_Homo sapiens_hsa053230.56439278
103Regulation of autophagy_Homo sapiens_hsa041400.56380262
104Renin-angiotensin system_Homo sapiens_hsa046140.56337913
105Alzheimers disease_Homo sapiens_hsa050100.55082568
106AMPK signaling pathway_Homo sapiens_hsa041520.54869072
107Arginine and proline metabolism_Homo sapiens_hsa003300.54603115
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54397433
109Fatty acid degradation_Homo sapiens_hsa000710.54194014
110GnRH signaling pathway_Homo sapiens_hsa049120.54132221
111TGF-beta signaling pathway_Homo sapiens_hsa043500.53803757
112Dilated cardiomyopathy_Homo sapiens_hsa054140.53534947
113RNA degradation_Homo sapiens_hsa030180.53268990
114Fatty acid biosynthesis_Homo sapiens_hsa000610.52342055
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52282384
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51875708
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51088362
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50009545
119Metabolic pathways_Homo sapiens_hsa011000.49899140
120PPAR signaling pathway_Homo sapiens_hsa033200.49739368
121beta-Alanine metabolism_Homo sapiens_hsa004100.49492723
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49154502
123Complement and coagulation cascades_Homo sapiens_hsa046100.48885488
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48874115
125Cardiac muscle contraction_Homo sapiens_hsa042600.48405091
126Glucagon signaling pathway_Homo sapiens_hsa049220.48286102
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46980516
128Mineral absorption_Homo sapiens_hsa049780.46226396
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.46050988
130Vitamin B6 metabolism_Homo sapiens_hsa007500.45667449
131Propanoate metabolism_Homo sapiens_hsa006400.45625411
132Gap junction_Homo sapiens_hsa045400.44669030
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44549026
134Ras signaling pathway_Homo sapiens_hsa040140.44486968
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.43603935
136Estrogen signaling pathway_Homo sapiens_hsa049150.43542429
137Pyruvate metabolism_Homo sapiens_hsa006200.41104356
138Glycerolipid metabolism_Homo sapiens_hsa005610.40151766
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39750290
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38752346
141N-Glycan biosynthesis_Homo sapiens_hsa005100.38037313
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36397684

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