VPS25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.64583634
2ribosomal small subunit assembly (GO:0000028)5.37375231
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.94020991
4chaperone-mediated protein transport (GO:0072321)4.69958891
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.41560494
6respiratory electron transport chain (GO:0022904)4.27648375
7electron transport chain (GO:0022900)4.17215297
8proteasome assembly (GO:0043248)4.09034138
9establishment of integrated proviral latency (GO:0075713)4.08612505
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.95433761
11signal peptide processing (GO:0006465)3.90820840
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87057205
13telomere maintenance via semi-conservative replication (GO:0032201)3.78675205
14rRNA modification (GO:0000154)3.77916382
15cotranslational protein targeting to membrane (GO:0006613)3.75633712
16protein targeting to ER (GO:0045047)3.73192896
17viral transcription (GO:0019083)3.66294147
18protein localization to endoplasmic reticulum (GO:0070972)3.60698168
19formation of translation preinitiation complex (GO:0001731)3.60337547
20translational termination (GO:0006415)3.59017400
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.56610349
22protein targeting to mitochondrion (GO:0006626)3.56527655
23DNA strand elongation involved in DNA replication (GO:0006271)3.53661077
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.53126639
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48937435
26establishment of viral latency (GO:0019043)3.43859212
27DNA strand elongation (GO:0022616)3.41614490
28oxidative phosphorylation (GO:0006119)3.40497863
29antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.40366453
30translational elongation (GO:0006414)3.37972476
31spliceosomal snRNP assembly (GO:0000387)3.37140569
32establishment of protein localization to mitochondrion (GO:0072655)3.35462415
33chromatin remodeling at centromere (GO:0031055)3.34851445
34regulation of ubiquitin-protein transferase activity (GO:0051438)3.32739898
35DNA replication checkpoint (GO:0000076)3.32019330
36protein localization to mitochondrion (GO:0070585)3.31836472
37regulation of cellular amino acid metabolic process (GO:0006521)3.30648529
38CENP-A containing nucleosome assembly (GO:0034080)3.28916904
39maturation of SSU-rRNA (GO:0030490)3.27726091
40translation (GO:0006412)3.26077840
41protein neddylation (GO:0045116)3.24724822
42telomere maintenance via recombination (GO:0000722)3.24696657
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23756314
44regulation of mitochondrial translation (GO:0070129)3.22553293
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19389833
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19203767
47inner mitochondrial membrane organization (GO:0007007)3.18704861
48peptidyl-histidine modification (GO:0018202)3.18410625
49purine nucleobase biosynthetic process (GO:0009113)3.18216603
50GDP-mannose metabolic process (GO:0019673)3.18039247
51signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17516103
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17516103
53regulation of ligase activity (GO:0051340)3.17438428
54negative regulation of ligase activity (GO:0051352)3.16753146
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16753146
56ribosomal small subunit biogenesis (GO:0042274)3.16644958
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16298836
58GTP biosynthetic process (GO:0006183)3.15933472
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14978077
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14978077
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14978077
62protein deneddylation (GO:0000338)3.12019959
63rRNA methylation (GO:0031167)3.11731536
64nucleobase biosynthetic process (GO:0046112)3.11177926
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10542707
66DNA damage response, detection of DNA damage (GO:0042769)3.09919454
67cullin deneddylation (GO:0010388)3.09180692
68signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01634535
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.01634535
70translational initiation (GO:0006413)3.01364909
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01211879
72maturation of 5.8S rRNA (GO:0000460)3.01175885
73guanosine-containing compound biosynthetic process (GO:1901070)2.99056716
74pteridine-containing compound biosynthetic process (GO:0042559)2.98688293
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98314701
76signal transduction involved in cell cycle checkpoint (GO:0072395)2.97585266
77regulation of cellular amine metabolic process (GO:0033238)2.96572978
78UTP biosynthetic process (GO:0006228)2.95200173
79antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.92503131
80pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.91644640
81purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91473560
82ribosomal large subunit biogenesis (GO:0042273)2.90548256
83deoxyribose phosphate biosynthetic process (GO:0046385)2.90207919
842-deoxyribonucleotide biosynthetic process (GO:0009265)2.90207919
85viral life cycle (GO:0019058)2.89990101
86telomere maintenance via telomere lengthening (GO:0010833)2.89901274
877-methylguanosine mRNA capping (GO:0006370)2.89590858
88transcription elongation from RNA polymerase III promoter (GO:0006385)2.89000990
89termination of RNA polymerase III transcription (GO:0006386)2.89000990
90heme biosynthetic process (GO:0006783)2.88622308
91transcription-coupled nucleotide-excision repair (GO:0006283)2.88620195
92purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88126065
93purine-containing compound salvage (GO:0043101)2.88103257
94L-serine metabolic process (GO:0006563)2.86511811
95negative regulation of protein ubiquitination (GO:0031397)2.85752172
96DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85358309
97nucleobase-containing small molecule interconversion (GO:0015949)2.84478219
98rRNA processing (GO:0006364)2.84340195
99CTP metabolic process (GO:0046036)2.84099146
100CTP biosynthetic process (GO:0006241)2.84099146
101energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84080698
102ATP synthesis coupled proton transport (GO:0015986)2.84080698
103respiratory chain complex IV assembly (GO:0008535)2.82948281
104pseudouridine synthesis (GO:0001522)2.81671131
105mitochondrial respiratory chain complex I assembly (GO:0032981)2.81049995
106NADH dehydrogenase complex assembly (GO:0010257)2.81049995
107mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81049995
108mitotic recombination (GO:0006312)2.79723655
109protein complex biogenesis (GO:0070271)2.79200994
110iron-sulfur cluster assembly (GO:0016226)2.78423732
111metallo-sulfur cluster assembly (GO:0031163)2.78423732
112ribonucleoprotein complex biogenesis (GO:0022613)2.77238436
113folic acid-containing compound biosynthetic process (GO:0009396)2.77084637
114cellular protein complex disassembly (GO:0043624)2.75142325
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72457097
116positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72113047
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71165915
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71165915
119nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70873053
120mitochondrial respiratory chain complex assembly (GO:0033108)2.70738359
121cytochrome complex assembly (GO:0017004)2.70556937
122L-methionine salvage (GO:0071267)2.70223618
123L-methionine biosynthetic process (GO:0071265)2.70223618
124amino acid salvage (GO:0043102)2.70223618
125heme metabolic process (GO:0042168)2.68195297
126nucleoside salvage (GO:0043174)2.67758940
127response to interferon-beta (GO:0035456)2.66810401
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.65220951
129positive regulation of ligase activity (GO:0051351)2.65118521
130cellular component biogenesis (GO:0044085)2.64237690
131DNA replication initiation (GO:0006270)2.64222548
132pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.63895806
133folic acid metabolic process (GO:0046655)2.62660554
134ribosome biogenesis (GO:0042254)2.61464169
135exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60900674
136positive regulation of cell cycle arrest (GO:0071158)2.58767162
137pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.57338907
138Golgi transport vesicle coating (GO:0048200)2.56699293
139COPI coating of Golgi vesicle (GO:0048205)2.56699293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.08716003
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01590706
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55557974
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.52439812
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.41318736
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36100546
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19911442
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.15146395
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.99185844
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.88780031
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76588224
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64879877
13* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51072136
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37312388
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.33465698
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.30309693
17* VDR_23849224_ChIP-Seq_CD4+_Human2.22630373
18* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16699793
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14036062
20* XRN2_22483619_ChIP-Seq_HELA_Human2.09540595
21* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07444874
22* DCP1A_22483619_ChIP-Seq_HELA_Human2.07232945
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04471053
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03034356
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02751156
26FOXP3_21729870_ChIP-Seq_TREG_Human2.01741811
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97837569
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95951430
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.95756400
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.94170698
31* GABP_19822575_ChIP-Seq_HepG2_Human1.91127087
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90860413
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89324771
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87994664
35* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83384705
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82315455
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81948992
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80917864
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78719916
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77219324
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.75951762
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74910390
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74124850
44* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62228505
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61631452
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59485127
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58635196
48TTF2_22483619_ChIP-Seq_HELA_Human1.54483595
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50339395
50* ELK1_19687146_ChIP-ChIP_HELA_Human1.45628855
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43610214
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40389088
53MYC_18940864_ChIP-ChIP_HL60_Human1.40095496
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38708422
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36260129
56GATA1_22025678_ChIP-Seq_K562_Human1.35278716
57* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32864097
58SPI1_23547873_ChIP-Seq_NB4_Human1.30119867
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29037827
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28164032
61CIITA_25753668_ChIP-Seq_RAJI_Human1.27000485
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26041020
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25138461
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25013210
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24274037
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24003867
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23625984
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20049116
69* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19994105
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19082393
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18634918
72MYC_22102868_ChIP-Seq_BL_Human1.17633967
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17359925
74* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14856187
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.13730657
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12955326
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.11945536
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10142947
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.09712786
80TFEB_21752829_ChIP-Seq_HELA_Human1.09439653
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08393504
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08033459
83KDM5A_27292631_Chip-Seq_BREAST_Human1.07312172
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06386343
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04722277
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04602288
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04508262
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04362768
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04203003
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.04130955
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.02472368
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.02020282
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00618649
94IRF8_21731497_ChIP-ChIP_J774_Mouse0.99449641
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98660934
96* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97998469
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96720626
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96633028
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95881131
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95451295
101PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95415367
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.95007856
103* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94855872
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94687290
105VDR_21846776_ChIP-Seq_THP-1_Human0.93276476
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92554336
107MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91462040
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90752181
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90681107
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90516516
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90381723
112FOXM1_23109430_ChIP-Seq_U2OS_Human0.90158441
113AR_21909140_ChIP-Seq_LNCAP_Human0.89850200
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89622999
115* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88136764
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88119815
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87917570
118FOXP1_21924763_ChIP-Seq_HESCs_Human0.83417504
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81525998
120ZNF274_21170338_ChIP-Seq_K562_Hela0.79208046
121* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77869611
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76629355
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73687693
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71917628
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71665703
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.70424581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.85437490
2MP0003693_abnormal_embryo_hatching3.40739407
3MP0003186_abnormal_redox_activity2.90684904
4MP0002938_white_spotting2.47967310
5MP0004957_abnormal_blastocyst_morpholog2.45452786
6MP0008789_abnormal_olfactory_epithelium2.36992008
7MP0001529_abnormal_vocalization2.35519768
8MP0001835_abnormal_antigen_presentation2.31493370
9MP0002139_abnormal_hepatobiliary_system2.25125398
10MP0006036_abnormal_mitochondrial_physio2.23194057
11MP0005365_abnormal_bile_salt2.21079472
12MP0002396_abnormal_hematopoietic_system2.16263771
13MP0010030_abnormal_orbit_morphology2.13317666
14MP0008058_abnormal_DNA_repair2.08725222
15MP0009785_altered_susceptibility_to2.08392901
16MP0010094_abnormal_chromosome_stability2.05426029
17MP0003656_abnormal_erythrocyte_physiolo2.04491335
18MP0000372_irregular_coat_pigmentation2.02682602
19MP0006292_abnormal_olfactory_placode1.94442868
20MP0003077_abnormal_cell_cycle1.88203480
21MP0005360_urolithiasis1.86237186
22MP0005085_abnormal_gallbladder_physiolo1.85824590
23MP0005671_abnormal_response_to1.84488200
24MP0001764_abnormal_homeostasis1.83637693
25MP0008007_abnormal_cellular_replicative1.79764164
26MP0001853_heart_inflammation1.78485697
27MP0000685_abnormal_immune_system1.76432201
28MP0005499_abnormal_olfactory_system1.74516980
29MP0005394_taste/olfaction_phenotype1.74516980
30MP0009333_abnormal_splenocyte_physiolog1.73351504
31MP0000490_abnormal_crypts_of1.72587562
32MP0005083_abnormal_biliary_tract1.72216796
33MP0003763_abnormal_thymus_physiology1.72190994
34MP0008875_abnormal_xenobiotic_pharmacok1.70084163
35MP0004147_increased_porphyrin_level1.69855136
36MP0006054_spinal_hemorrhage1.67939772
37MP0003724_increased_susceptibility_to1.66719918
38MP0003011_delayed_dark_adaptation1.63306973
39MP0002132_abnormal_respiratory_system1.62895223
40MP0003111_abnormal_nucleus_morphology1.61327997
41MP0003941_abnormal_skin_development1.60737358
42MP0003436_decreased_susceptibility_to1.60484827
43MP0002148_abnormal_hypersensitivity_rea1.60362978
44MP0005025_abnormal_response_to1.56870091
45MP0006072_abnormal_retinal_apoptosis1.50278157
46MP0001293_anophthalmia1.48574440
47MP0002163_abnormal_gland_morphology1.45209512
48MP0009697_abnormal_copulation1.43228303
49MP0005075_abnormal_melanosome_morpholog1.42474773
50MP0009840_abnormal_foam_cell1.41933456
51MP0003123_paternal_imprinting1.41503433
52MP0005319_abnormal_enzyme/_coenzyme1.39710000
53MP0001545_abnormal_hematopoietic_system1.39582334
54MP0005397_hematopoietic_system_phenotyp1.39582334
55MP0009643_abnormal_urine_homeostasis1.39221365
56MP0008057_abnormal_DNA_replication1.37690679
57MP0002398_abnormal_bone_marrow1.35990481
58MP0008469_abnormal_protein_level1.34016344
59MP0005332_abnormal_amino_acid1.32882991
60MP0000689_abnormal_spleen_morphology1.30722662
61MP0008995_early_reproductive_senescence1.29742599
62MP0005464_abnormal_platelet_physiology1.29364154
63MP0002722_abnormal_immune_system1.27585595
64MP0005058_abnormal_lysosome_morphology1.27554225
65MP0002837_dystrophic_cardiac_calcinosis1.27032275
66MP0004133_heterotaxia1.25151697
67MP0003786_premature_aging1.25018814
68MP0001800_abnormal_humoral_immune1.24576936
69MP0003136_yellow_coat_color1.24375201
70MP0002429_abnormal_blood_cell1.23946738
71MP0001984_abnormal_olfaction1.23840908
72MP0005379_endocrine/exocrine_gland_phen1.23141159
73MP0005636_abnormal_mineral_homeostasis1.23006121
74MP0002723_abnormal_immune_serum1.22917161
75MP0008932_abnormal_embryonic_tissue1.22841307
76MP0002405_respiratory_system_inflammati1.22828608
77MP0003195_calcinosis1.22812135
78MP0002419_abnormal_innate_immunity1.22786252
79MP0005000_abnormal_immune_tolerance1.22532751
80MP0002420_abnormal_adaptive_immunity1.22426472
81MP0001845_abnormal_inflammatory_respons1.22046208
82MP0001819_abnormal_immune_cell1.20851050
83MP0000858_altered_metastatic_potential1.20177664
84MP0002160_abnormal_reproductive_system1.18847408
85MP0003315_abnormal_perineum_morphology1.17356698
86MP0000716_abnormal_immune_system1.17113118
87MP0002452_abnormal_antigen_presenting1.16997883
88MP0010155_abnormal_intestine_physiology1.16006602
89MP0003937_abnormal_limbs/digits/tail_de1.13135251
90MP0003567_abnormal_fetal_cardiomyocyte1.12588570
91MP0002210_abnormal_sex_determination1.12229507
92MP0005220_abnormal_exocrine_pancreas1.12193012
93MP0009379_abnormal_foot_pigmentation1.11666232
94MP0004782_abnormal_surfactant_physiolog1.11606818
95MP0002019_abnormal_tumor_incidence1.10190192
96MP0002138_abnormal_hepatobiliary_system1.09731867
97MP0000350_abnormal_cell_proliferation1.09673625
98MP0001666_abnormal_nutrient_absorption1.09526235
99MP0005584_abnormal_enzyme/coenzyme_acti1.07206850
100MP0002102_abnormal_ear_morphology1.07103697
101MP0001929_abnormal_gametogenesis1.06960387
102MP0001697_abnormal_embryo_size1.06439985
103MP0002233_abnormal_nose_morphology1.05774418
104MP0000609_abnormal_liver_physiology1.04376677
105MP0000566_synostosis1.03675288
106MP0002653_abnormal_ependyma_morphology1.03253115
107MP0000598_abnormal_liver_morphology1.03110035
108MP0001790_abnormal_immune_system1.02513523
109MP0005387_immune_system_phenotype1.02513523
110MP0001873_stomach_inflammation1.00867027
111MP0003191_abnormal_cellular_cholesterol1.00798404
112MP0002090_abnormal_vision0.99757716
113MP0006035_abnormal_mitochondrial_morpho0.98977553
114MP0003121_genomic_imprinting0.98849860
115MP0000313_abnormal_cell_death0.98503961
116MP0008877_abnormal_DNA_methylation0.96440410
117MP0003122_maternal_imprinting0.95160257
118MP0000647_abnormal_sebaceous_gland0.95127516
119MP0000358_abnormal_cell_content/0.94581672
120MP0000343_altered_response_to0.94448814
121MP0002080_prenatal_lethality0.94021398
122MP0004019_abnormal_vitamin_homeostasis0.93725048
123MP0005266_abnormal_metabolism0.93336369
124MP0003866_abnormal_defecation0.93118402
125MP0002085_abnormal_embryonic_tissue0.92751815
126MP0001145_abnormal_male_reproductive0.92704097
127MP0001346_abnormal_lacrimal_gland0.90711749
128MP0001986_abnormal_taste_sensitivity0.90369719
129MP0005380_embryogenesis_phenotype0.90114466
130MP0001672_abnormal_embryogenesis/_devel0.90114466
131MP0005253_abnormal_eye_physiology0.89332722
132MP0000653_abnormal_sex_gland0.89096516
133MP0002277_abnormal_respiratory_mucosa0.88696984
134MP0010329_abnormal_lipoprotein_level0.86472908
135MP0001756_abnormal_urination0.86243197
136MP0003878_abnormal_ear_physiology0.85668707
137MP0005377_hearing/vestibular/ear_phenot0.85668707
138MP0002084_abnormal_developmental_patter0.85019255
139MP0009763_increased_sensitivity_to0.83215530
140MP0002693_abnormal_pancreas_physiology0.82558549
141MP0005408_hypopigmentation0.82546975
142MP0000465_gastrointestinal_hemorrhage0.81606803
143MP0000703_abnormal_thymus_morphology0.81257073
144MP0001286_abnormal_eye_development0.80835015
145MP0002166_altered_tumor_susceptibility0.80629322
146MP0003718_maternal_effect0.80089434
147MP0005376_homeostasis/metabolism_phenot0.79272699
148MP0005551_abnormal_eye_electrophysiolog0.79264846
149MP0002697_abnormal_eye_size0.77807341
150MP0001542_abnormal_bone_strength0.76631433
151MP0000049_abnormal_middle_ear0.75955026
152MP0005084_abnormal_gallbladder_morpholo0.75574301
153MP0005389_reproductive_system_phenotype0.75371218
154MP0003890_abnormal_embryonic-extraembry0.74945839
155MP0002282_abnormal_trachea_morphology0.74647880
156MP0001324_abnormal_eye_pigmentation0.74023787
157MP0001727_abnormal_embryo_implantation0.73886881
158MP0001730_embryonic_growth_arrest0.73106850
159MP0003984_embryonic_growth_retardation0.72753987
160MP0004808_abnormal_hematopoietic_stem0.72484031
161MP0002088_abnormal_embryonic_growth/wei0.69800932
162MP0001661_extended_life_span0.69524944
163MP0003119_abnormal_digestive_system0.68897224
164MP0002751_abnormal_autonomic_nervous0.68870748
165MP0005391_vision/eye_phenotype0.67416627
166MP0003698_abnormal_male_reproductive0.67391053
167MP0002111_abnormal_tail_morphology0.67323185

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.08260387
2Abnormal number of erythroid precursors (HP:0012131)3.88578813
3Abnormality of cells of the erythroid lineage (HP:0012130)3.86035688
4Decreased activity of mitochondrial respiratory chain (HP:0008972)3.76062839
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.76062839
6Hepatocellular necrosis (HP:0001404)3.73482420
7Type I transferrin isoform profile (HP:0003642)3.68570560
8Increased serum pyruvate (HP:0003542)3.53499373
9Generalized aminoaciduria (HP:0002909)3.47352093
10Abnormality of glycolysis (HP:0004366)3.46936998
11Mitochondrial inheritance (HP:0001427)3.37626250
12Aplastic anemia (HP:0001915)3.37046369
13Acute necrotizing encephalopathy (HP:0006965)3.36865654
14Abnormal mitochondria in muscle tissue (HP:0008316)3.30202930
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.29920788
16Reduced antithrombin III activity (HP:0001976)3.18238777
17Increased CSF lactate (HP:0002490)3.17502080
18Acute encephalopathy (HP:0006846)3.16905958
19Reticulocytopenia (HP:0001896)3.00575924
20Thrombocytosis (HP:0001894)3.00464932
21Abnormal protein glycosylation (HP:0012346)2.93952564
22Abnormal glycosylation (HP:0012345)2.93952564
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.93952564
24Abnormal protein N-linked glycosylation (HP:0012347)2.93952564
25Increased serum lactate (HP:0002151)2.92620244
26Oral leukoplakia (HP:0002745)2.92020230
27Lipid accumulation in hepatocytes (HP:0006561)2.91618291
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.87320696
29Microretrognathia (HP:0000308)2.81372102
30Hypoglycemic coma (HP:0001325)2.79992103
31Lactic acidosis (HP:0003128)2.77162767
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72814111
33Increased hepatocellular lipid droplets (HP:0006565)2.72183043
34IgM deficiency (HP:0002850)2.70362655
35Increased muscle lipid content (HP:0009058)2.66170708
36Hyperglycinemia (HP:0002154)2.63037775
37Vacuolated lymphocytes (HP:0001922)2.60530171
38Nausea (HP:0002018)2.59679491
39Abnormality of fatty-acid metabolism (HP:0004359)2.57952713
40Meckel diverticulum (HP:0002245)2.56949325
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52933281
42Dicarboxylic aciduria (HP:0003215)2.52933281
43Cerebral edema (HP:0002181)2.52310762
44Increased intramyocellular lipid droplets (HP:0012240)2.52294671
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50726300
46Progressive macrocephaly (HP:0004481)2.50067511
47Renal Fanconi syndrome (HP:0001994)2.48817520
48Abnormality of the anterior horn cell (HP:0006802)2.46720276
49Degeneration of anterior horn cells (HP:0002398)2.46720276
50Petechiae (HP:0000967)2.46412564
51Abnormality of the ileum (HP:0001549)2.45419456
52Macrocytic anemia (HP:0001972)2.45362720
53Exertional dyspnea (HP:0002875)2.42268939
543-Methylglutaconic aciduria (HP:0003535)2.42198945
55Hyperbilirubinemia (HP:0002904)2.37006412
56Leukodystrophy (HP:0002415)2.34991297
57Exercise intolerance (HP:0003546)2.30986688
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30686256
59Microvesicular hepatic steatosis (HP:0001414)2.29045969
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28896387
61Glycosuria (HP:0003076)2.28513744
62Abnormality of urine glucose concentration (HP:0011016)2.28513744
63Lethargy (HP:0001254)2.27113268
64Birth length less than 3rd percentile (HP:0003561)2.23963460
65Optic disc pallor (HP:0000543)2.22445761
66Elevated erythrocyte sedimentation rate (HP:0003565)2.22413011
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20531226
68Poor head control (HP:0002421)2.20369414
69Pallor (HP:0000980)2.19671046
70Abnormality of the preputium (HP:0100587)2.18009616
71Pancytopenia (HP:0001876)2.17837564
72Respiratory failure (HP:0002878)2.15515728
73Beaking of vertebral bodies (HP:0004568)2.09571520
74Late onset (HP:0003584)2.07727517
75Pancreatic fibrosis (HP:0100732)2.05271329
76Medial flaring of the eyebrow (HP:0010747)2.05151872
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.03005523
78Rough bone trabeculation (HP:0100670)2.01767032
79Chromsome breakage (HP:0040012)1.99430931
80Abnormal gallbladder physiology (HP:0012438)1.99287536
81Cholecystitis (HP:0001082)1.99287536
82Recurrent abscess formation (HP:0002722)1.98986730
83Methylmalonic aciduria (HP:0012120)1.98659843
84Respiratory difficulties (HP:0002880)1.97469431
85Multiple enchondromatosis (HP:0005701)1.97005127
86Pancreatic cysts (HP:0001737)1.96263981
87Abnormal lung lobation (HP:0002101)1.95026264
88Abnormality of pyrimidine metabolism (HP:0004353)1.94223287
89Abnormality of alanine metabolism (HP:0010916)1.92687390
90Hyperalaninemia (HP:0003348)1.92687390
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92687390
92Hypoplastic pelvis (HP:0008839)1.92386487
93Horseshoe kidney (HP:0000085)1.92024605
94Proximal tubulopathy (HP:0000114)1.91912755
95Gout (HP:0001997)1.91276487
96CNS demyelination (HP:0007305)1.90114666
97Abnormality of T cell physiology (HP:0011840)1.89890278
98Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89157297
99Hyperammonemia (HP:0001987)1.88656751
100Hypobetalipoproteinemia (HP:0003563)1.88578401
101True hermaphroditism (HP:0010459)1.88148438
10211 pairs of ribs (HP:0000878)1.86512173
103Hyperglycinuria (HP:0003108)1.86445818
104Opisthotonus (HP:0002179)1.85661100
105Methylmalonic acidemia (HP:0002912)1.84591830
106Myositis (HP:0100614)1.84569701
107Abnormality of the intrinsic pathway (HP:0010989)1.83260151
108Sclerocornea (HP:0000647)1.81828078
109Abnormality of serine family amino acid metabolism (HP:0010894)1.80837605
110Abnormality of glycine metabolism (HP:0010895)1.80837605
111Emotional lability (HP:0000712)1.80695574
112Vomiting (HP:0002013)1.80478089
113Recurrent bacterial skin infections (HP:0005406)1.80299486
114X-linked dominant inheritance (HP:0001423)1.79921792
115Congenital primary aphakia (HP:0007707)1.79478572
116Neutropenia (HP:0001875)1.79368400
117Molar tooth sign on MRI (HP:0002419)1.79339112
118Abnormality of midbrain morphology (HP:0002418)1.79339112
119Abnormality of the labia minora (HP:0012880)1.78703214
120Colon cancer (HP:0003003)1.78315848
121Ragged-red muscle fibers (HP:0003200)1.77912015
122Facial cleft (HP:0002006)1.76211734
123Cerebral hypomyelination (HP:0006808)1.75055145
124Hyperphosphaturia (HP:0003109)1.74475940
125Metabolic acidosis (HP:0001942)1.73384245
126Palpitations (HP:0001962)1.71478428
127Megaloblastic anemia (HP:0001889)1.71080935
128Cerebral palsy (HP:0100021)1.69301828
129Abnormality of chromosome stability (HP:0003220)1.69100497
130Ketosis (HP:0001946)1.66757423
131Brushfield spots (HP:0001088)1.65786607
132Prolonged partial thromboplastin time (HP:0003645)1.65634432
133Abnormality of reticulocytes (HP:0004312)1.65075495
134Abnormality of renal resorption (HP:0011038)1.63703274
135Steatorrhea (HP:0002570)1.63277986
136Sparse eyelashes (HP:0000653)1.62785405
137Abnormality of methionine metabolism (HP:0010901)1.62782882
138Abnormality of serum amino acid levels (HP:0003112)1.62121580
139Intrahepatic cholestasis (HP:0001406)1.61877089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.67890967
2STK163.64383619
3NME23.40740606
4BUB13.23564811
5BCKDK3.19202758
6EIF2AK13.10075597
7EIF2AK32.53008113
8PIM22.51906208
9WEE12.41203893
10ERN12.40247387
11TTK2.31111332
12KDR2.11865365
13VRK12.08866844
14TESK22.07815114
15PDK22.03396161
16ACVR1B1.94592784
17MAP4K11.82271152
18SRPK11.82016391
19TRIM281.81006943
20BRSK21.77292553
21NEK11.73081364
22MAP3K121.70103183
23FLT31.69685065
24MAP3K111.60523001
25MAP4K21.57831044
26WNK31.55534262
27PASK1.52878022
28ZAP701.48633255
29NME11.46152476
30MYLK1.42214655
31NUAK11.35279113
32PLK41.34373066
33TBK11.33709031
34CDC71.33247032
35PBK1.28395107
36TESK11.27475984
37BLK1.25744674
38MAP2K31.25436956
39BTK1.23880032
40TAF11.23140432
41TEC1.21800767
42BRSK11.21001397
43MAP3K31.17492280
44KIT1.11257532
45RPS6KB21.10635357
46JAK31.09550115
47DYRK21.08956707
48ARAF1.06485694
49IRAK41.05903603
50CHEK21.05060917
51SIK31.05028227
52TYK21.05025610
53MAPKAPK30.99934799
54TSSK60.98720582
55TXK0.97302135
56BMPR1B0.94329160
57CDK80.93910688
58MST40.93387688
59CSNK1G30.93376436
60TLK10.91754782
61BRAF0.91232022
62TGFBR10.90925804
63CCNB10.90808362
64IKBKE0.88841183
65IRAK30.87444650
66SCYL20.85116975
67RPS6KA40.84716646
68PIM10.84659793
69CDK70.84610458
70ZAK0.84162439
71AURKB0.83466041
72PLK10.83344034
73NEK20.81712979
74ILK0.80803471
75ABL20.79335838
76IKBKB0.79184881
77AURKA0.79180632
78NEK90.78952037
79CSNK1G10.78621431
80NLK0.75765834
81BCR0.75573732
82PAK40.74644787
83CDK190.74396616
84MAP2K70.73341312
85MAP2K60.72300212
86MKNK20.71870104
87PIK3CG0.70426886
88CSNK1A1L0.70182354
89STK240.69803619
90SYK0.69659439
91ATR0.69407814
92LRRK20.69112741
93RPS6KA50.67237310
94DYRK30.66962368
95EIF2AK20.64996265
96CSNK1G20.64877075
97CSNK2A10.62814371
98LYN0.61678728
99EPHA20.61655100
100MAP3K140.60536358
101CHEK10.59950706
102CAMKK20.57360965
103STK100.55548479
104PAK10.54742725
105DAPK10.53983803
106DAPK30.53827464
107LIMK10.52549364
108MAP3K80.52428804
109ERBB30.51945805
110PRKG20.51020600
111TGFBR20.50915862
112LMTK20.50542121
113MAPK150.50180945
114ATM0.49930242
115MAPK110.49831859
116STK40.49605151
117PLK20.48033051
118ERBB40.47934216
119CSNK2A20.47861263
120RPS6KA60.44561175
121GRK10.43129571
122MAP3K40.43093455
123MUSK0.39825651
124PRKCD0.38523696
125CDK40.38262791
126PLK30.37522489
127LCK0.37403312
128MKNK10.37070830
129MAPKAPK20.36752665
130AKT20.36729359
131CSNK1E0.35476537
132MAP3K50.35202547
133PRKCI0.34823714
134INSRR0.32316234
135PRKCG0.28716657
136CSNK1A10.28596635
137CDK10.27490573
138EPHB20.26882364
139ALK0.25867581
140PNCK0.25675577
141CLK10.24780396
142FGFR10.24763988

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.74072436
2Ribosome_Homo sapiens_hsa030103.58129652
3DNA replication_Homo sapiens_hsa030303.41692862
4Protein export_Homo sapiens_hsa030602.97090539
5Mismatch repair_Homo sapiens_hsa034302.73978661
6RNA polymerase_Homo sapiens_hsa030202.58481594
7Pyrimidine metabolism_Homo sapiens_hsa002402.27038340
8Base excision repair_Homo sapiens_hsa034102.24123764
9Homologous recombination_Homo sapiens_hsa034402.08510548
10Folate biosynthesis_Homo sapiens_hsa007901.95426757
11Oxidative phosphorylation_Homo sapiens_hsa001901.90624591
12Parkinsons disease_Homo sapiens_hsa050121.84556833
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80774732
14Nucleotide excision repair_Homo sapiens_hsa034201.78337510
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76153612
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75295693
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.73630058
18One carbon pool by folate_Homo sapiens_hsa006701.71785408
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70468917
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64167398
21Spliceosome_Homo sapiens_hsa030401.63285811
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56451844
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56059149
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.54051375
25Steroid biosynthesis_Homo sapiens_hsa001001.43965870
26Pentose phosphate pathway_Homo sapiens_hsa000301.43131531
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35633287
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33152118
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.31189758
30RNA transport_Homo sapiens_hsa030131.30639497
31Sulfur relay system_Homo sapiens_hsa041221.28203725
32Huntingtons disease_Homo sapiens_hsa050161.25756966
33Non-homologous end-joining_Homo sapiens_hsa034501.25529385
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24732852
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20325854
36Selenocompound metabolism_Homo sapiens_hsa004501.19466750
37Carbon metabolism_Homo sapiens_hsa012001.18169032
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17383086
39RNA degradation_Homo sapiens_hsa030181.14781377
40Purine metabolism_Homo sapiens_hsa002301.13574211
41Biosynthesis of amino acids_Homo sapiens_hsa012301.13242205
42Galactose metabolism_Homo sapiens_hsa000521.09081325
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.08547885
44Peroxisome_Homo sapiens_hsa041461.08368092
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.07592670
46Glutathione metabolism_Homo sapiens_hsa004801.07303256
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04700216
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.02670583
49Fatty acid degradation_Homo sapiens_hsa000711.01487498
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00434456
51Cardiac muscle contraction_Homo sapiens_hsa042601.00242129
52N-Glycan biosynthesis_Homo sapiens_hsa005101.00041972
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99672893
54Other glycan degradation_Homo sapiens_hsa005110.98981432
55Alzheimers disease_Homo sapiens_hsa050100.98280323
56Butanoate metabolism_Homo sapiens_hsa006500.98074278
57Fructose and mannose metabolism_Homo sapiens_hsa000510.94749415
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93143046
59Sulfur metabolism_Homo sapiens_hsa009200.91964864
60Cell cycle_Homo sapiens_hsa041100.90533049
61Legionellosis_Homo sapiens_hsa051340.88318070
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88012280
63Pyruvate metabolism_Homo sapiens_hsa006200.87422579
64Caffeine metabolism_Homo sapiens_hsa002320.87121413
65Antigen processing and presentation_Homo sapiens_hsa046120.85059626
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83833353
67Vitamin B6 metabolism_Homo sapiens_hsa007500.82962392
68Fanconi anemia pathway_Homo sapiens_hsa034600.77691706
69Tryptophan metabolism_Homo sapiens_hsa003800.77182036
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76692402
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76028288
72Basal transcription factors_Homo sapiens_hsa030220.75436309
73Chemical carcinogenesis_Homo sapiens_hsa052040.75208644
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74830419
75Propanoate metabolism_Homo sapiens_hsa006400.73448864
76Metabolic pathways_Homo sapiens_hsa011000.73057247
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71596074
78Primary immunodeficiency_Homo sapiens_hsa053400.71025915
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70108831
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69751958
81Fatty acid elongation_Homo sapiens_hsa000620.66667590
82p53 signaling pathway_Homo sapiens_hsa041150.63123273
83Collecting duct acid secretion_Homo sapiens_hsa049660.62939729
84Phenylalanine metabolism_Homo sapiens_hsa003600.62394515
85beta-Alanine metabolism_Homo sapiens_hsa004100.60146473
86Epstein-Barr virus infection_Homo sapiens_hsa051690.56893791
87Histidine metabolism_Homo sapiens_hsa003400.54699265
88Herpes simplex infection_Homo sapiens_hsa051680.54232039
89Vibrio cholerae infection_Homo sapiens_hsa051100.54213827
90Tyrosine metabolism_Homo sapiens_hsa003500.53319207
91mRNA surveillance pathway_Homo sapiens_hsa030150.51762666
92Starch and sucrose metabolism_Homo sapiens_hsa005000.50990966
93Fat digestion and absorption_Homo sapiens_hsa049750.50288390
94Asthma_Homo sapiens_hsa053100.49883672
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48247919
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.48134698
97Regulation of autophagy_Homo sapiens_hsa041400.46769956
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45650761
99Arginine and proline metabolism_Homo sapiens_hsa003300.43871818
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43323255
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43135711
102Arginine biosynthesis_Homo sapiens_hsa002200.42611116
103Arachidonic acid metabolism_Homo sapiens_hsa005900.42190527
104Vitamin digestion and absorption_Homo sapiens_hsa049770.41923266
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41415041
106Hematopoietic cell lineage_Homo sapiens_hsa046400.40749832
107Oocyte meiosis_Homo sapiens_hsa041140.39865237
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.39001177
109Fatty acid metabolism_Homo sapiens_hsa012120.38321925
110Allograft rejection_Homo sapiens_hsa053300.37601539
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37521110
112Measles_Homo sapiens_hsa051620.37292824
113Retinol metabolism_Homo sapiens_hsa008300.36883489
114Lysosome_Homo sapiens_hsa041420.32963724
115Leishmaniasis_Homo sapiens_hsa051400.31301151
116Systemic lupus erythematosus_Homo sapiens_hsa053220.29711969
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29561600
118Nitrogen metabolism_Homo sapiens_hsa009100.19455098
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.19279571
120Phototransduction_Homo sapiens_hsa047440.16022237
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14823849

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