VPS16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.75179522
2DNA strand elongation involved in DNA replication (GO:0006271)5.06868766
3DNA strand elongation (GO:0022616)4.99651213
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.97617394
5negative regulation of cell killing (GO:0031342)4.97617394
6negative regulation of erythrocyte differentiation (GO:0045647)4.73842704
7telomere maintenance via semi-conservative replication (GO:0032201)4.53161226
8ribosomal small subunit assembly (GO:0000028)4.52232176
9DNA replication initiation (GO:0006270)4.37299419
10positive regulation by symbiont of host defense response (GO:0052509)4.17833096
11modulation by symbiont of host defense response (GO:0052031)4.17833096
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17833096
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17833096
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.17833096
15modulation by symbiont of host immune response (GO:0052553)4.17833096
16nucleobase biosynthetic process (GO:0046112)4.17181966
17response to peptidoglycan (GO:0032494)4.06609438
18telomere maintenance via recombination (GO:0000722)4.03336766
19protein localization to kinetochore (GO:0034501)4.01552382
20IMP biosynthetic process (GO:0006188)4.00872596
21mitotic recombination (GO:0006312)3.98087512
22DNA replication checkpoint (GO:0000076)3.93603662
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92461125
24antigen processing and presentation of endogenous antigen (GO:0019883)3.87280978
25detection of other organism (GO:0098543)3.86208873
26response to muramyl dipeptide (GO:0032495)3.82217001
27detection of bacterium (GO:0016045)3.80884377
28maturation of SSU-rRNA (GO:0030490)3.78962722
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.68318945
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.66255372
31mitotic chromosome condensation (GO:0007076)3.63978508
32formation of translation preinitiation complex (GO:0001731)3.61818129
33telomere maintenance via telomere lengthening (GO:0010833)3.56535349
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55806489
35negative regulation of interleukin-12 production (GO:0032695)3.55668931
36leukocyte aggregation (GO:0070486)3.48485232
37histone H2A acetylation (GO:0043968)3.47587076
38NIK/NF-kappaB signaling (GO:0038061)3.47513616
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.45948887
40purine nucleobase biosynthetic process (GO:0009113)3.44400905
41nuclear pore organization (GO:0006999)3.42468506
42viral transcription (GO:0019083)3.41860786
43protein localization to chromosome, centromeric region (GO:0071459)3.40856481
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40825528
45regulation of mast cell degranulation (GO:0043304)3.37936662
46IMP metabolic process (GO:0046040)3.37263898
47DNA duplex unwinding (GO:0032508)3.34803560
48macrophage activation involved in immune response (GO:0002281)3.34162074
49regulation of T cell tolerance induction (GO:0002664)3.34139320
50folic acid-containing compound biosynthetic process (GO:0009396)3.33987422
51postreplication repair (GO:0006301)3.33055736
52nuclear pore complex assembly (GO:0051292)3.32470448
53DNA geometric change (GO:0032392)3.32107602
54cullin deneddylation (GO:0010388)3.30057247
55regulation of leukocyte degranulation (GO:0043300)3.30043952
56translational termination (GO:0006415)3.28394999
57dosage compensation (GO:0007549)3.26275537
58negative regulation of RNA splicing (GO:0033119)3.26126462
59mitotic sister chromatid segregation (GO:0000070)3.25978273
60response to interleukin-15 (GO:0070672)3.25338622
61cellular response to interleukin-15 (GO:0071350)3.24037800
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23414316
63neutrophil activation involved in immune response (GO:0002283)3.22836376
64mitotic nuclear envelope disassembly (GO:0007077)3.21771591
65translational elongation (GO:0006414)3.21087974
66regulation of gamma-delta T cell activation (GO:0046643)3.19236532
67immunoglobulin mediated immune response (GO:0016064)3.18498567
68detection of external biotic stimulus (GO:0098581)3.18212245
69sister chromatid segregation (GO:0000819)3.17912363
70spliceosomal snRNP assembly (GO:0000387)3.17329495
71translesion synthesis (GO:0019985)3.16891004
72ribosomal large subunit biogenesis (GO:0042273)3.14454211
73ribosomal small subunit biogenesis (GO:0042274)3.12831746
74barbed-end actin filament capping (GO:0051016)3.12214035
75mRNA splicing, via spliceosome (GO:0000398)3.11712898
76RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.11712898
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.11585447
78kinetochore organization (GO:0051383)3.09909712
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07474680
80attachment of spindle microtubules to kinetochore (GO:0008608)3.07446646
81regulation of mast cell activation involved in immune response (GO:0033006)3.06536745
82RNA splicing, via transesterification reactions (GO:0000375)3.05875119
83Golgi transport vesicle coating (GO:0048200)3.05838453
84COPI coating of Golgi vesicle (GO:0048205)3.05838453
85regulation of type I interferon-mediated signaling pathway (GO:0060338)3.05303750
86translational initiation (GO:0006413)3.04823112
87snRNA processing (GO:0016180)3.03916664
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.03382853
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02851861
90CENP-A containing nucleosome assembly (GO:0034080)3.02405938
91regulation of superoxide anion generation (GO:0032928)3.02280763
92ribonucleoprotein complex biogenesis (GO:0022613)3.01968722
93positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01397214
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00592275
95regulation of tolerance induction (GO:0002643)3.00461550
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99870762
97mitotic metaphase plate congression (GO:0007080)2.99691489
98ribosome biogenesis (GO:0042254)2.98633848
99regulation of interferon-beta biosynthetic process (GO:0045357)2.97760317
100DNA replication-independent nucleosome assembly (GO:0006336)2.97743067
101DNA replication-independent nucleosome organization (GO:0034724)2.97743067
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97665076
103telomere organization (GO:0032200)2.96995028
104negative regulation of leukocyte mediated immunity (GO:0002704)2.96679887
105telomere maintenance (GO:0000723)2.96654830
106membrane disassembly (GO:0030397)2.96060470
107nuclear envelope disassembly (GO:0051081)2.96060470
108DNA topological change (GO:0006265)2.96016895
109regulation of B cell receptor signaling pathway (GO:0050855)2.94859153
110positive regulation of histone H3-K4 methylation (GO:0051571)2.93124489
111chromatin remodeling at centromere (GO:0031055)2.92185836
112metaphase plate congression (GO:0051310)2.91903118
113snRNA metabolic process (GO:0016073)2.91703586
114signal complex assembly (GO:0007172)2.90816680
1153-UTR-mediated mRNA stabilization (GO:0070935)2.90751640
116interferon-gamma secretion (GO:0072643)2.90717119
117negative regulation of DNA-templated transcription, elongation (GO:0032785)2.89983863
118negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.89983863
119regulation of regulated secretory pathway (GO:1903305)2.89932177
120regulation of histone H3-K9 methylation (GO:0051570)2.89252127
121viral mRNA export from host cell nucleus (GO:0046784)2.89185634
122peptidyl-arginine omega-N-methylation (GO:0035247)2.88969685
123protein deneddylation (GO:0000338)2.88745620
124protein localization to chromosome (GO:0034502)2.88496570
125pore complex assembly (GO:0046931)2.86739637
126base-excision repair (GO:0006284)2.85499471
127negative regulation of mRNA processing (GO:0050686)2.85382549
128negative regulation of histone methylation (GO:0031061)2.84137096
129termination of RNA polymerase II transcription (GO:0006369)2.82684532
130detection of molecule of bacterial origin (GO:0032490)2.82372115
131histone mRNA metabolic process (GO:0008334)2.82361543
132cellular protein complex disassembly (GO:0043624)2.80882337
133regulation of defense response to virus by virus (GO:0050690)2.80812622
134detection of biotic stimulus (GO:0009595)2.80615844
135mannose metabolic process (GO:0006013)2.80480216
136negative regulation of innate immune response (GO:0045824)2.79684796
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.79610667
138rRNA processing (GO:0006364)2.78408074
139cellular response to type I interferon (GO:0071357)2.77955563
140type I interferon signaling pathway (GO:0060337)2.77955563
141regulation of T-helper 2 cell differentiation (GO:0045628)2.77846122
142regulation of centriole replication (GO:0046599)2.77552938
143lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77171803
144positive regulation of gamma-delta T cell activation (GO:0046645)2.77123074
145spliceosomal complex assembly (GO:0000245)2.76987177
146establishment of chromosome localization (GO:0051303)2.76965003
147DNA conformation change (GO:0071103)2.76524902
148negative thymic T cell selection (GO:0045060)2.75752520
149rRNA metabolic process (GO:0016072)2.74129859
150DNA replication-dependent nucleosome organization (GO:0034723)2.74128810
151DNA replication-dependent nucleosome assembly (GO:0006335)2.74128810
152negative regulation of T cell mediated immunity (GO:0002710)2.74072035
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.73811133
154regulation of translation in response to stress (GO:0043555)2.73785773
155protein complex disassembly (GO:0043241)2.72809103
156respiratory burst (GO:0045730)2.71975011
157positive regulation of B cell differentiation (GO:0045579)2.71222429
158retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.71194405
159response to type I interferon (GO:0034340)2.71165206
160kinetochore assembly (GO:0051382)2.70806817
161regulation of DNA endoreduplication (GO:0032875)2.70590752
162cotranslational protein targeting to membrane (GO:0006613)2.70039253
163T cell migration (GO:0072678)2.69845987
164intra-S DNA damage checkpoint (GO:0031573)2.69777475
165alternative mRNA splicing, via spliceosome (GO:0000380)2.69474555
166B cell receptor signaling pathway (GO:0050853)2.69279423
167viral life cycle (GO:0019058)2.69239647
168amino sugar catabolic process (GO:0046348)2.65216580
169actin nucleation (GO:0045010)2.64849584
170modulation by virus of host process (GO:0019054)2.64581898
171modulation by symbiont of host cellular process (GO:0044068)2.64569013
172negative T cell selection (GO:0043383)2.64361166
173negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64194894
174negative regulation of type 2 immune response (GO:0002829)2.62286811
175negative regulation of cytokine production involved in immune response (GO:0002719)2.60882306
176positive regulation of mast cell activation (GO:0033005)2.60291254
177positive regulation of mast cell degranulation (GO:0043306)2.57304062
178positive regulation of mast cell activation involved in immune response (GO:0033008)2.57304062
179viral protein processing (GO:0019082)2.57060805
180actin filament polymerization (GO:0030041)2.56866072
181granulocyte activation (GO:0036230)2.56618922
182positive regulation of leukocyte degranulation (GO:0043302)2.56004656
183thymic T cell selection (GO:0045061)2.54812515
184positive thymic T cell selection (GO:0045059)2.54697756
185regulation of gamma-delta T cell differentiation (GO:0045586)2.53303161
186positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.51958432
187positive regulation of regulated secretory pathway (GO:1903307)2.50209901
188neutrophil activation (GO:0042119)2.50172939
189retrograde transport, endosome to Golgi (GO:0042147)2.49357248
190germinal center formation (GO:0002467)2.49342376
191response to host immune response (GO:0052572)2.48745992
192response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48745992
193response to host defenses (GO:0052200)2.47971656
194response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47971656
195response to host (GO:0075136)2.47971656
196negative regulation of cell size (GO:0045792)2.47918165
197positive regulation of cellular amide metabolic process (GO:0034250)2.47810061
198positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47693160
199T cell selection (GO:0045058)2.47659478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.26348244
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.98555678
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69699832
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.62255966
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60247645
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.09898274
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.88973686
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78614865
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77114140
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75363985
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.71566905
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64305857
13LXR_22292898_ChIP-Seq_THP-1_Human2.62189637
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61229149
15MYC_22102868_ChIP-Seq_BL_Human2.60428466
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59755149
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58921292
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.56313260
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.56213489
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51780417
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51602013
22CIITA_25753668_ChIP-Seq_RAJI_Human2.50951310
23XRN2_22483619_ChIP-Seq_HELA_Human2.44950214
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.39881243
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.38242435
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.36827114
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34901456
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.31445488
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27643762
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22682563
31VDR_23849224_ChIP-Seq_CD4+_Human2.20421955
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18672529
33FOXP3_21729870_ChIP-Seq_TREG_Human2.16378058
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16184410
35KDM2B_26808549_Chip-Seq_DND41_Human2.14919269
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07288944
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.94231584
38VDR_21846776_ChIP-Seq_THP-1_Human1.93995625
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92211591
40TCF7_22412390_ChIP-Seq_EML_Mouse1.90475554
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89320974
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89096029
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88641253
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87365662
45DCP1A_22483619_ChIP-Seq_HELA_Human1.85251011
46GABP_19822575_ChIP-Seq_HepG2_Human1.80228725
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78437030
48TTF2_22483619_ChIP-Seq_HELA_Human1.78296050
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77524909
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77238106
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75461590
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72204720
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.71826905
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71355618
55KDM5A_27292631_Chip-Seq_BREAST_Human1.71262075
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68969000
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68601849
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66828657
59* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65858669
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65350873
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64155979
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64148318
63* YY1_21170310_ChIP-Seq_MESCs_Mouse1.62116110
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.61604500
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61300899
66* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61093743
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60091602
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59867790
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58726167
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58283492
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.57689106
72P68_20966046_ChIP-Seq_HELA_Human1.57608616
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57161028
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.56783144
75RACK7_27058665_Chip-Seq_MCF-7_Human1.55801553
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55629975
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55556885
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53645182
79BCL6_27268052_Chip-Seq_Bcells_Human1.52390633
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52302956
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51160696
82* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51143697
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.50875288
84AR_21909140_ChIP-Seq_LNCAP_Human1.50869056
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.48456680
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47823904
87* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47563118
88* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46982340
89SPI1_23127762_ChIP-Seq_K562_Human1.46979165
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46332540
91* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44963088
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44245443
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42636086
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42265010
95KDM2B_26808549_Chip-Seq_K562_Human1.42000211
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41703011
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40858419
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.40157716
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37880500
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37809271
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37188387
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36548496
103BCOR_27268052_Chip-Seq_Bcells_Human1.36221210
104* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35784407
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33960303
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32887163
107TFEB_21752829_ChIP-Seq_HELA_Human1.32426367
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31941102
109ELK1_19687146_ChIP-ChIP_HELA_Human1.31826203
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.30538130
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29348132
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28133383
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27770288
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26420615
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24885519
116SMC4_20622854_ChIP-Seq_HELA_Human1.24826234
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24230174
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23888405
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22495274
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22403832
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.21925667
122UTX_26944678_Chip-Seq_JUKART_Human1.21786251
123NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20546596
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20156325
125* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19441908
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18973566
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18391202
128PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17196330
129* CTCF_26484167_Chip-Seq_Bcells_Mouse1.16465393
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15382716
131SPI1_23547873_ChIP-Seq_NB4_Human1.14040318
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13504885
133NCOR1_26117541_ChIP-Seq_K562_Human1.10258241
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10066153
135* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10029956
136MAF_26560356_Chip-Seq_TH1_Human1.09561915
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09409882
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08688471
139IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08405093
140TP53_22127205_ChIP-Seq_IMR90_Human1.08124156
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06746154
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05677771
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04721135
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04184509
145* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03472079
146CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03273246
147KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02953093
148* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02107418
149GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01080409
150CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00285276
151* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99991914
152MYC_18940864_ChIP-ChIP_HL60_Human0.97667923
153NOTCH1_21737748_ChIP-Seq_TLL_Human0.96522177
154MYB_26560356_Chip-Seq_TH2_Human0.96416227
155KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96050155
156MYB_26560356_Chip-Seq_TH1_Human0.93353753
157STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92026948
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91650365
159DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90559917
160RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90544189
161MAF_26560356_Chip-Seq_TH2_Human0.89572434
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89118248
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88867756
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86548326
165SCL_19346495_ChIP-Seq_HPC-7_Human0.85760845
166CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84956882
167* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84621492
168CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81762352
169TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81074791
170VDR_24763502_ChIP-Seq_THP-1_Human0.80386313
171* RUNX1_22412390_ChIP-Seq_EML_Mouse0.78731703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.78910769
2MP0003111_abnormal_nucleus_morphology4.01844800
3MP0003693_abnormal_embryo_hatching3.98876970
4MP0005058_abnormal_lysosome_morphology3.90398252
5MP0003436_decreased_susceptibility_to3.85782729
6MP0003077_abnormal_cell_cycle3.81066279
7MP0004957_abnormal_blastocyst_morpholog3.51090476
8MP0003172_abnormal_lysosome_physiology3.49601542
9MP0008058_abnormal_DNA_repair3.46777262
10MP0002396_abnormal_hematopoietic_system3.42690039
11MP0008057_abnormal_DNA_replication3.20475760
12MP0003724_increased_susceptibility_to3.04993378
13MP0003300_gastrointestinal_ulcer2.92300108
14MP0005451_abnormal_body_composition2.91377777
15MP0008007_abnormal_cellular_replicative2.73943101
16MP0008877_abnormal_DNA_methylation2.60208808
17MP0003763_abnormal_thymus_physiology2.54283480
18MP0002419_abnormal_innate_immunity2.52468468
19MP0003191_abnormal_cellular_cholesterol2.38805630
20MP0006082_CNS_inflammation2.25373342
21MP0000703_abnormal_thymus_morphology2.25044755
22MP0003123_paternal_imprinting2.23689944
23MP0004808_abnormal_hematopoietic_stem2.21562982
24MP0008932_abnormal_embryonic_tissue2.18178199
25MP0000350_abnormal_cell_proliferation2.16177482
26MP0002398_abnormal_bone_marrow2.14264583
27MP0001730_embryonic_growth_arrest2.07628732
28MP0000604_amyloidosis1.97294295
29MP0003329_amyloid_beta_deposits1.94334524
30MP0009785_altered_susceptibility_to1.86903288
31MP0003121_genomic_imprinting1.86776398
32MP0000490_abnormal_crypts_of1.83753148
33MP0002722_abnormal_immune_system1.80819285
34MP0001533_abnormal_skeleton_physiology1.79458158
35MP0000689_abnormal_spleen_morphology1.79393658
36MP0001800_abnormal_humoral_immune1.76868895
37MP0009840_abnormal_foam_cell1.74709667
38MP0004947_skin_inflammation1.70792396
39MP0005671_abnormal_response_to1.70165340
40MP0010307_abnormal_tumor_latency1.69360681
41MP0009333_abnormal_splenocyte_physiolog1.68549492
42MP0002148_abnormal_hypersensitivity_rea1.68356907
43MP0003303_peritoneal_inflammation1.68064468
44MP0000313_abnormal_cell_death1.58587277
45MP0000716_abnormal_immune_system1.57968192
46MP0002429_abnormal_blood_cell1.57634784
47MP0003787_abnormal_imprinting1.52210630
48MP0002080_prenatal_lethality1.51391206
49MP0002019_abnormal_tumor_incidence1.48685248
50MP0004510_myositis1.47582952
51MP0001835_abnormal_antigen_presentation1.46290793
52MP0001697_abnormal_embryo_size1.45439644
53MP0002420_abnormal_adaptive_immunity1.44974129
54MP0002877_abnormal_melanocyte_morpholog1.43553273
55MP0003786_premature_aging1.43342626
56MP0001672_abnormal_embryogenesis/_devel1.40669464
57MP0005380_embryogenesis_phenotype1.40669464
58MP0001819_abnormal_immune_cell1.39785625
59MP0003690_abnormal_glial_cell1.33341257
60MP0002452_abnormal_antigen_presenting1.31359143
61MP0001849_ear_inflammation1.31215615
62MP0001845_abnormal_inflammatory_respons1.29914673
63MP0002723_abnormal_immune_serum1.29157651
64MP0004858_abnormal_nervous_system1.28105428
65MP0000015_abnormal_ear_pigmentation1.28065173
66MP0005174_abnormal_tail_pigmentation1.28029880
67MP0000537_abnormal_urethra_morphology1.24559672
68MP0003866_abnormal_defecation1.24483510
69MP0003984_embryonic_growth_retardation1.23524096
70MP0008469_abnormal_protein_level1.23292234
71MP0005075_abnormal_melanosome_morpholog1.22021446
72MP0000685_abnormal_immune_system1.20455890
73MP0002088_abnormal_embryonic_growth/wei1.19615811
74MP0010352_gastrointestinal_tract_polyps1.19418930
75MP0009764_decreased_sensitivity_to1.17806027
76MP0001529_abnormal_vocalization1.16927577
77MP0004147_increased_porphyrin_level1.16160507
78MP0000343_altered_response_to1.15542819
79MP0008260_abnormal_autophagy1.13959528
80MP0004859_abnormal_synaptic_plasticity1.11585892
81MP0002998_abnormal_bone_remodeling1.11080411
82MP0005397_hematopoietic_system_phenotyp1.10999941
83MP0001545_abnormal_hematopoietic_system1.10999941
84MP0002085_abnormal_embryonic_tissue1.10329595
85MP0003705_abnormal_hypodermis_morpholog1.09247399
86MP0004197_abnormal_fetal_growth/weight/1.07285140
87MP0003075_altered_response_to1.06490663
88MP0002751_abnormal_autonomic_nervous1.05772454
89MP0008004_abnormal_stomach_pH1.04645563
90MP0001958_emphysema1.03992346
91MP0003221_abnormal_cardiomyocyte_apopto1.03339789
92MP0003315_abnormal_perineum_morphology1.02258927
93MP0009672_abnormal_birth_weight1.01827399
94MP0002132_abnormal_respiratory_system1.00784734
95MP0002210_abnormal_sex_determination0.99424081
96MP0002166_altered_tumor_susceptibility0.99327369
97MP0005076_abnormal_cell_differentiation0.98845381
98MP0005000_abnormal_immune_tolerance0.97833707
99MP0004381_abnormal_hair_follicle0.97546717
100MP0002084_abnormal_developmental_patter0.96528092
101MP0000858_altered_metastatic_potential0.96308365
102MP0009765_abnormal_xenobiotic_induced0.95097196
103MP0002933_joint_inflammation0.93301867
104MP0003091_abnormal_cell_migration0.92907723
105MP0003879_abnormal_hair_cell0.91573493
106MP0000920_abnormal_myelination0.91566071
107MP0009763_increased_sensitivity_to0.90781519
108MP0003634_abnormal_glial_cell0.90736504
109MP0001145_abnormal_male_reproductive0.90717139
110MP0005387_immune_system_phenotype0.88821779
111MP0001790_abnormal_immune_system0.88821779
112MP0008874_decreased_physiological_sensi0.88365305
113MP0002095_abnormal_skin_pigmentation0.87517269
114MP0000358_abnormal_cell_content/0.87457114
115MP0002006_tumorigenesis0.87249620
116MP0002086_abnormal_extraembryonic_tissu0.86086053
117MP0000747_muscle_weakness0.82740147
118MP0005384_cellular_phenotype0.82277287
119MP0004185_abnormal_adipocyte_glucose0.80138026
120MP0003122_maternal_imprinting0.79390649
121MP0005390_skeleton_phenotype0.79200655
122MP0002405_respiratory_system_inflammati0.78786707
123MP0003656_abnormal_erythrocyte_physiolo0.78601519
124MP0005166_decreased_susceptibility_to0.78230426
125MP0003183_abnormal_peptide_metabolism0.78225151
126MP0001853_heart_inflammation0.78126364
127MP0003566_abnormal_cell_adhesion0.77370211
128MP0001851_eye_inflammation0.77224561
129MP0001663_abnormal_digestive_system0.77210717
130MP0003943_abnormal_hepatobiliary_system0.77181116
131MP0005464_abnormal_platelet_physiology0.76945143
132MP0000465_gastrointestinal_hemorrhage0.76944189
133MP0009278_abnormal_bone_marrow0.76675732
134MP0005310_abnormal_salivary_gland0.75542765
135MP0003279_aneurysm0.75405993
136MP0003453_abnormal_keratinocyte_physiol0.74142243
137MP0009379_abnormal_foot_pigmentation0.71450160
138MP0008995_early_reproductive_senescence0.71363315
139MP0010155_abnormal_intestine_physiology0.71292273
140MP0003115_abnormal_respiratory_system0.70760187
141MP0003828_pulmonary_edema0.70639558
142MP0005621_abnormal_cell_physiology0.70211620
143MP0005248_abnormal_Harderian_gland0.69270069
144MP0003880_abnormal_central_pattern0.69231755
145MP0001873_stomach_inflammation0.69178269
146MP0005025_abnormal_response_to0.68645949
147MP0001915_intracranial_hemorrhage0.68002704
148MP0003448_altered_tumor_morphology0.67899612
149MP0008770_decreased_survivor_rate0.67779877
150MP0000750_abnormal_muscle_regeneration0.67316840
151MP0001293_anophthalmia0.67293487
152MP0003861_abnormal_nervous_system0.66790013
153MP0001929_abnormal_gametogenesis0.66635167
154MP0002083_premature_death0.66553874
155MP0003795_abnormal_bone_structure0.66367628
156MP0001348_abnormal_lacrimal_gland0.64687309
157MP0001727_abnormal_embryo_implantation0.64364095
158MP0008789_abnormal_olfactory_epithelium0.63574991
159MP0000653_abnormal_sex_gland0.62753670
160MP0005499_abnormal_olfactory_system0.61558330
161MP0005394_taste/olfaction_phenotype0.61558330

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.78731875
2Abnormal number of erythroid precursors (HP:0012131)4.09460124
3Abnormality of macrophages (HP:0004311)4.03915215
4Abnormality of cells of the erythroid lineage (HP:0012130)3.99617011
5Recurrent bacterial skin infections (HP:0005406)3.98441700
6Cerebral hypomyelination (HP:0006808)3.94003292
7Recurrent abscess formation (HP:0002722)3.78612843
8Reticulocytopenia (HP:0001896)3.38202609
9Abnormality of glycolipid metabolism (HP:0010969)3.31406735
10Abnormality of liposaccharide metabolism (HP:0010968)3.31406735
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.31406735
12Loss of speech (HP:0002371)3.26706671
13Myositis (HP:0100614)3.22530555
14Birth length less than 3rd percentile (HP:0003561)3.18012860
15Dysostosis multiplex (HP:0000943)3.11686178
16Mediastinal lymphadenopathy (HP:0100721)3.10265956
17Supranuclear gaze palsy (HP:0000605)3.02845942
18Recurrent gram-negative bacterial infections (HP:0005420)3.01675786
19Cellulitis (HP:0100658)2.95862994
20IgM deficiency (HP:0002850)2.90165307
21Gastrointestinal infarctions (HP:0005244)2.89908164
22Increased IgE level (HP:0003212)2.86652839
23Basal cell carcinoma (HP:0002671)2.82810194
24Systemic lupus erythematosus (HP:0002725)2.81645051
25Neuronal loss in central nervous system (HP:0002529)2.79978965
26Aplastic anemia (HP:0001915)2.77036205
27Orchitis (HP:0100796)2.75988840
28Chronic obstructive pulmonary disease (HP:0006510)2.75362018
29Obstructive lung disease (HP:0006536)2.75362018
30Chronic otitis media (HP:0000389)2.72574183
31Ependymoma (HP:0002888)2.72390189
32Agnosia (HP:0010524)2.70074803
33Colon cancer (HP:0003003)2.68510589
34Chromsome breakage (HP:0040012)2.67939873
35Patellar aplasia (HP:0006443)2.66992763
36Abnormality of the labia minora (HP:0012880)2.58195456
37Gingivitis (HP:0000230)2.57335470
38Recurrent fungal infections (HP:0002841)2.57165315
39Increased cerebral lipofuscin (HP:0011813)2.55300712
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.53994464
41Thrombocytosis (HP:0001894)2.53448534
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52714645
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52159184
44Abnormality of polysaccharide metabolism (HP:0011012)2.52159184
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52159184
46Hypoplasia of the capital femoral epiphysis (HP:0003090)2.49735774
47Oral leukoplakia (HP:0002745)2.49609778
48Mucopolysacchariduria (HP:0008155)2.47511518
49Urinary glycosaminoglycan excretion (HP:0003541)2.47511518
50Aplasia/Hypoplasia of the patella (HP:0006498)2.47436700
51Recurrent skin infections (HP:0001581)2.47028073
52Panhypogammaglobulinemia (HP:0003139)2.44801160
53Recurrent viral infections (HP:0004429)2.43884745
54Abnormality of chromosome stability (HP:0003220)2.41346429
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41266418
56Myelodysplasia (HP:0002863)2.41176058
57Neurofibrillary tangles (HP:0002185)2.40639758
58Retrobulbar optic neuritis (HP:0100654)2.39731988
59Optic neuritis (HP:0100653)2.39731988
60Neoplasm of the pancreas (HP:0002894)2.38053517
61Abnormal gallbladder physiology (HP:0012438)2.37748082
62Cholecystitis (HP:0001082)2.37748082
63Pallor (HP:0000980)2.37656651
64Meckel diverticulum (HP:0002245)2.36796203
65Pelvic girdle muscle weakness (HP:0003749)2.36366646
66Abnormality of the preputium (HP:0100587)2.33446270
67Hepatosplenomegaly (HP:0001433)2.32515974
68Recurrent bronchitis (HP:0002837)2.31409351
69Ectopic kidney (HP:0000086)2.31349695
70Cervical subluxation (HP:0003308)2.31236838
71Meningitis (HP:0001287)2.30910525
72Peripheral hypomyelination (HP:0007182)2.30604436
73Interstitial pulmonary disease (HP:0006530)2.29179531
74J-shaped sella turcica (HP:0002680)2.27366089
75Abnormality of B cell number (HP:0010975)2.24331716
76B lymphocytopenia (HP:0010976)2.24331716
77Abnormality of the ileum (HP:0001549)2.23934560
78Medulloblastoma (HP:0002885)2.23313613
79Prolonged neonatal jaundice (HP:0006579)2.22259620
80Diminished motivation (HP:0000745)2.21910323
81Amaurosis fugax (HP:0100576)2.21675584
82Proximal placement of thumb (HP:0009623)2.20300014
83Lymphoma (HP:0002665)2.19569539
84Amyloidosis (HP:0011034)2.19390563
85Increased nuchal translucency (HP:0010880)2.18485410
86Breast hypoplasia (HP:0003187)2.18003950
87Ragged-red muscle fibers (HP:0003200)2.17488050
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.15748244
89Squamous cell carcinoma (HP:0002860)2.15631548
90Progressive neurologic deterioration (HP:0002344)2.15118578
91Macrocytic anemia (HP:0001972)2.14922205
92Abnormality of the anterior horn cell (HP:0006802)2.14898170
93Degeneration of anterior horn cells (HP:0002398)2.14898170
94Bone marrow hypocellularity (HP:0005528)2.14841936
95Cellular immunodeficiency (HP:0005374)2.14505155
96Recurrent cutaneous fungal infections (HP:0011370)2.14072374
97Chronic mucocutaneous candidiasis (HP:0002728)2.14072374
98Distal lower limb amyotrophy (HP:0008944)2.13929517
99Small intestinal stenosis (HP:0012848)2.13893874
100Duodenal stenosis (HP:0100867)2.13893874
101Gastrointestinal inflammation (HP:0004386)2.13022544
102Urticaria (HP:0001025)2.12643355
103Selective tooth agenesis (HP:0001592)2.11941020
104IgG deficiency (HP:0004315)2.11620867
105Vertebral compression fractures (HP:0002953)2.10995069
106Colitis (HP:0002583)2.10955842
107T lymphocytopenia (HP:0005403)2.10547080
108Purpura (HP:0000979)2.10473401
109Apathy (HP:0000741)2.10338001
110Acute hepatic failure (HP:0006554)2.10336393
111Abnormal lung lobation (HP:0002101)2.10009878
112Upper motor neuron abnormality (HP:0002127)2.07308207
113Abnormality of the hip-girdle musculature (HP:0001445)2.06328010
114Abnormality of the musculature of the pelvis (HP:0001469)2.06328010
115Stomatitis (HP:0010280)2.05866481
116Episodic fever (HP:0001954)2.04909546
117Abnormality of DNA repair (HP:0003254)2.04251374
118Chest pain (HP:0100749)2.03571842
119Abnormality of the heme biosynthetic pathway (HP:0010472)2.03558503
120CNS hypomyelination (HP:0003429)2.02758667
121Difficulty climbing stairs (HP:0003551)2.01410139
122Premature graying of hair (HP:0002216)2.01367294
123Elevated erythrocyte sedimentation rate (HP:0003565)2.01361202
124Spontaneous hematomas (HP:0007420)2.01317084
125Inflammation of the large intestine (HP:0002037)2.00360733
126Vacuolated lymphocytes (HP:0001922)1.99735164
127Cafe-au-lait spot (HP:0000957)1.99681727
128Hyperacusis (HP:0010780)1.98073430
129Rapidly progressive (HP:0003678)1.97871009
130Cerebral inclusion bodies (HP:0100314)1.97787618
131Distal upper limb amyotrophy (HP:0007149)1.97612884
132Upper limb amyotrophy (HP:0009129)1.97612884
133Abnormal number of incisors (HP:0011064)1.96395661
134Abnormality of the fingertips (HP:0001211)1.95215880
135Personality changes (HP:0000751)1.94875975
136Abnormality of T cells (HP:0002843)1.94536510
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.93816057
138Ankle clonus (HP:0011448)1.93638442
139Peritonitis (HP:0002586)1.93035542
140Hypertensive crisis (HP:0100735)1.91714080
141Cerebral aneurysm (HP:0004944)1.91212872
142Vasculitis (HP:0002633)1.90407295
143Centrally nucleated skeletal muscle fibers (HP:0003687)1.90392454
144Short 4th metacarpal (HP:0010044)1.90301884
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90301884
146Horseshoe kidney (HP:0000085)1.88183672
147Increased IgM level (HP:0003496)1.87706014
148Hypergammaglobulinemia (HP:0010702)1.87395486
149Agammaglobulinemia (HP:0004432)1.86068726
150Premature loss of primary teeth (HP:0006323)1.85308162
151Deviation of the thumb (HP:0009603)1.85043864
152Thin bony cortex (HP:0002753)1.83869092
153Hand muscle atrophy (HP:0009130)1.83027973
154Poikiloderma (HP:0001029)1.82458509
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.82388716
156Petechiae (HP:0000967)1.82217513
15711 pairs of ribs (HP:0000878)1.81734763
158Polygenic inheritance (HP:0010982)1.81523421
159Postnatal microcephaly (HP:0005484)1.81372451
160Gingival bleeding (HP:0000225)1.80724071
161Prominent nose (HP:0000448)1.79837479
162Gastrointestinal dysmotility (HP:0002579)1.79785584
163Abnormality of T cell number (HP:0011839)1.79729959
164Pancytopenia (HP:0001876)1.79488728
165Atrophy/Degeneration involving motor neurons (HP:0007373)1.79451498
166Increased variability in muscle fiber diameter (HP:0003557)1.79213437
167Fatigue (HP:0012378)1.79098918
168Encephalitis (HP:0002383)1.78862834
169Thoracic kyphosis (HP:0002942)1.78776832
170Abnormality of the peritoneum (HP:0002585)1.78671939
171Pointed chin (HP:0000307)1.78499608
172Osteomyelitis (HP:0002754)1.78309625
173Supernumerary nipples (HP:0002558)1.78264034
174Sloping forehead (HP:0000340)1.78017444
175Joint stiffness (HP:0001387)1.77922033
176Pustule (HP:0200039)1.77150453
177Rough bone trabeculation (HP:0100670)1.73577460
178Lymphopenia (HP:0001888)1.72040610
179Facial hemangioma (HP:0000329)1.70089797
180Abnormality of cells of the lymphoid lineage (HP:0012140)1.69056370
181High pitched voice (HP:0001620)1.68805908
182Astrocytoma (HP:0009592)1.67729803
183Abnormality of the astrocytes (HP:0100707)1.67729803
184Emotional lability (HP:0000712)1.66219687
185Abnormality of reticulocytes (HP:0004312)1.65787053
186Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65216970
187Shoulder girdle muscle weakness (HP:0003547)1.64335254
188Combined immunodeficiency (HP:0005387)1.64157803
189Volvulus (HP:0002580)1.63349881
190Absent epiphyses (HP:0010577)1.63041106
191Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63041106
192Embryonal renal neoplasm (HP:0011794)1.62593127
193Abnormality of the duodenum (HP:0002246)1.62572223
194Duplicated collecting system (HP:0000081)1.62235285
195Broad distal phalanx of finger (HP:0009836)1.62217162
196Gonadotropin excess (HP:0000837)1.61734498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.43884876
2BUB14.17040557
3TSSK63.28160748
4TRIB33.19298773
5WEE12.98431876
6MAP4K12.91429797
7MAP2K32.72458525
8NEK22.72331431
9ERN12.67504931
10CCNB12.62343884
11MAP3K112.41995201
12EIF2AK12.37916403
13RIPK42.35099005
14PLK42.21035929
15EPHB12.12459749
16SRPK12.11996186
17ICK2.07572409
18TLK12.06964562
19CDK191.99871440
20MKNK11.97723208
21PASK1.92785216
22EEF2K1.84533676
23SCYL21.83400110
24NEK11.82792682
25TESK11.76710763
26TBK11.74282563
27SMG11.72382971
28BLK1.70370450
29IRAK31.67349775
30GRK61.65757323
31ATR1.61912883
32MAP3K61.57095258
33SIK11.56067413
34CSK1.51854506
35FGFR41.49903348
36IRAK41.47906913
37PLK11.45390663
38MAP3K31.44439179
39ZAP701.42056731
40ACVR1B1.38443766
41STK161.36788394
42PLK31.35342027
43VRK11.35206511
44MARK21.34588096
45CSF1R1.28925458
46MAP3K101.25985879
47TAOK11.25277780
48JAK31.23646532
49SIK21.20404470
50BCKDK1.17482507
51MKNK21.14579362
52BTK1.13729155
53EPHA31.13619090
54TXK1.13205655
55MATK1.12928409
56MAP3K141.12569624
57BRSK21.12044216
58CDK71.09501758
59TAOK21.08946595
60FGR1.08852296
61KSR21.07849243
62BRSK11.06490930
63SYK1.05043446
64AURKB1.04588938
65EIF2AK31.03219467
66MAP3K11.02930940
67TGFBR11.02473091
68PRKD21.01803725
69CHEK11.00135765
70NME20.97781865
71MAP2K40.96196412
72SIK30.95726769
73CDK40.95607543
74STK100.95335564
75IKBKE0.93941324
76HCK0.93053949
77TESK20.92970039
78KDR0.92908347
79PTK60.91917079
80AURKA0.90215580
81CHEK20.90072493
82PLK20.89259412
83TYK20.88573438
84JAK10.86825810
85CDK20.84910533
86ITK0.84660889
87TTN0.84574702
88KIT0.83133917
89TTK0.82818451
90TNK20.81798574
91BRD40.81762214
92BRAF0.81664352
93RET0.79153630
94RPS6KB20.78175339
95PRPF4B0.77710136
96DYRK1B0.77230084
97DAPK10.75736403
98ERBB30.74011706
99JAK20.73887847
100LCK0.73696430
101LMTK20.73067156
102UHMK10.72916127
103PIM10.72336186
104MAP3K50.71605076
105PDPK10.71108063
106PKN20.70989428
107MAPK120.70719592
108CDC42BPA0.68440663
109MOS0.67822426
110RIPK10.67793507
111FES0.67273348
112PDGFRA0.66024038
113IRAK20.65917068
114RPS6KA20.65518788
115LIMK10.65250829
116PAK60.63987415
117PDK10.63899364
118NME10.63708396
119CSNK2A20.61912997
120NTRK10.61473566
121CDK10.61351916
122CDK11A0.61202299
123RAF10.60509938
124RPS6KA50.60288367
125FYN0.60226887
126FLT30.59967064
127MELK0.59748431
128MAP3K80.59368460
129RPS6KB10.59139310
130CDK120.58049223
131ATM0.57827975
132CDK180.57157162
133CDK150.56265237
134RPS6KA40.56128852
135CLK10.56098947
136CSNK1G30.55743201
137LYN0.55424708
138LRRK20.55005716
139YES10.54624788
140TYRO30.54099177
141MAPK110.52113982
142PNCK0.51933746
143PAK10.51684248
144MAP3K130.50068684
145DYRK20.49020019
146CAMKK10.48988570
147BMX0.47101054
148ALK0.46539963
149KSR10.46410905
150FGFR30.46381300
151RPS6KA60.45820126
152PIM20.44509884
153MAP2K70.43593181
154CASK0.43135220
155IKBKB0.42974477
156MAP3K70.42967533
157CDK140.42884723
158RPS6KL10.42583582
159RPS6KC10.42583582
160ARAF0.41791050
161NTRK20.41147230
162CSNK2A10.39852518
163MARK30.39844912
164BMPR20.36245472
165PRKD30.36024821
166MAPK70.34143254
167DDR20.32441686

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15114903
2Mismatch repair_Homo sapiens_hsa034303.95691937
3Other glycan degradation_Homo sapiens_hsa005113.47047352
4Spliceosome_Homo sapiens_hsa030403.47007529
5Base excision repair_Homo sapiens_hsa034103.27793302
6Ribosome_Homo sapiens_hsa030102.88938779
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87909136
8Homologous recombination_Homo sapiens_hsa034402.86566509
9Proteasome_Homo sapiens_hsa030502.73912169
10RNA transport_Homo sapiens_hsa030132.70015234
11RNA polymerase_Homo sapiens_hsa030202.69978318
12Non-homologous end-joining_Homo sapiens_hsa034502.68215361
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.68004176
14Cell cycle_Homo sapiens_hsa041102.38537286
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33767715
16Nucleotide excision repair_Homo sapiens_hsa034202.33293165
17One carbon pool by folate_Homo sapiens_hsa006702.31149800
18Glycosaminoglycan degradation_Homo sapiens_hsa005312.23255611
19Pyrimidine metabolism_Homo sapiens_hsa002402.02779008
20Fanconi anemia pathway_Homo sapiens_hsa034602.00645748
21Primary immunodeficiency_Homo sapiens_hsa053401.87830512
22Staphylococcus aureus infection_Homo sapiens_hsa051501.87123207
23Tuberculosis_Homo sapiens_hsa051521.76157163
24Lysosome_Homo sapiens_hsa041421.73448400
25mRNA surveillance pathway_Homo sapiens_hsa030151.72815960
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72614043
27RNA degradation_Homo sapiens_hsa030181.70927793
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63917471
29Salmonella infection_Homo sapiens_hsa051321.48771468
30Epstein-Barr virus infection_Homo sapiens_hsa051691.47762707
31Phagosome_Homo sapiens_hsa041451.45968737
32Pertussis_Homo sapiens_hsa051331.35575868
33Galactose metabolism_Homo sapiens_hsa000521.30937023
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29838932
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27258791
36Allograft rejection_Homo sapiens_hsa053301.23533185
37Malaria_Homo sapiens_hsa051441.22160911
38B cell receptor signaling pathway_Homo sapiens_hsa046621.13536074
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13403548
40Herpes simplex infection_Homo sapiens_hsa051681.11032022
41p53 signaling pathway_Homo sapiens_hsa041151.10566033
42Autoimmune thyroid disease_Homo sapiens_hsa053201.09231655
43T cell receptor signaling pathway_Homo sapiens_hsa046601.08088194
44Oocyte meiosis_Homo sapiens_hsa041141.06262157
45Purine metabolism_Homo sapiens_hsa002301.05829748
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.04849026
47Graft-versus-host disease_Homo sapiens_hsa053321.04280272
48Viral carcinogenesis_Homo sapiens_hsa052031.03995730
49Vibrio cholerae infection_Homo sapiens_hsa051101.03483019
50Antigen processing and presentation_Homo sapiens_hsa046121.01637448
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96992624
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.95017183
53Measles_Homo sapiens_hsa051620.92813588
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92512674
55Prion diseases_Homo sapiens_hsa050200.92265227
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90825523
57TNF signaling pathway_Homo sapiens_hsa046680.90677755
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89660765
59Basal transcription factors_Homo sapiens_hsa030220.89443700
60Chronic myeloid leukemia_Homo sapiens_hsa052200.88796218
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88232149
62Bladder cancer_Homo sapiens_hsa052190.87913136
63GnRH signaling pathway_Homo sapiens_hsa049120.85662648
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.85587797
65Shigellosis_Homo sapiens_hsa051310.84870682
66Prolactin signaling pathway_Homo sapiens_hsa049170.84733618
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83760123
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.83291752
69Non-small cell lung cancer_Homo sapiens_hsa052230.82308579
70HTLV-I infection_Homo sapiens_hsa051660.81767398
71Asthma_Homo sapiens_hsa053100.80706111
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79956304
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78932546
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76905311
75Synaptic vesicle cycle_Homo sapiens_hsa047210.76104552
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.75773349
77Thyroid cancer_Homo sapiens_hsa052160.74779041
78Colorectal cancer_Homo sapiens_hsa052100.73723904
79Rheumatoid arthritis_Homo sapiens_hsa053230.73187204
80Acute myeloid leukemia_Homo sapiens_hsa052210.72657685
81Apoptosis_Homo sapiens_hsa042100.72137039
82Systemic lupus erythematosus_Homo sapiens_hsa053220.72082799
83Hepatitis B_Homo sapiens_hsa051610.68946490
84Choline metabolism in cancer_Homo sapiens_hsa052310.67553771
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.67345939
86Platelet activation_Homo sapiens_hsa046110.64190787
87African trypanosomiasis_Homo sapiens_hsa051430.61797593
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60939558
89Small cell lung cancer_Homo sapiens_hsa052220.60463316
90Alcoholism_Homo sapiens_hsa050340.59815990
91Notch signaling pathway_Homo sapiens_hsa043300.59445436
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59439266
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.59279487
94N-Glycan biosynthesis_Homo sapiens_hsa005100.58862138
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58139207
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58038799
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57558366
98Type I diabetes mellitus_Homo sapiens_hsa049400.56820985
99Inositol phosphate metabolism_Homo sapiens_hsa005620.56781396
100Folate biosynthesis_Homo sapiens_hsa007900.56588888
101Collecting duct acid secretion_Homo sapiens_hsa049660.56512506
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.56463607
103Pancreatic cancer_Homo sapiens_hsa052120.56139669
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.56112694
105Influenza A_Homo sapiens_hsa051640.55182538
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54518485
107Hematopoietic cell lineage_Homo sapiens_hsa046400.53494707
108MicroRNAs in cancer_Homo sapiens_hsa052060.52762324
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51188509
110Insulin signaling pathway_Homo sapiens_hsa049100.50599261
111Legionellosis_Homo sapiens_hsa051340.49882316
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48210750
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47503556
114Biosynthesis of amino acids_Homo sapiens_hsa012300.47369028
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45064654
116mTOR signaling pathway_Homo sapiens_hsa041500.44866102
117Leishmaniasis_Homo sapiens_hsa051400.42265977
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41913507
119Endometrial cancer_Homo sapiens_hsa052130.39489334
120Pentose phosphate pathway_Homo sapiens_hsa000300.39006888
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37794499
122Sulfur relay system_Homo sapiens_hsa041220.37622904
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35703628
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35280947
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34631301
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.34500899
127Glioma_Homo sapiens_hsa052140.29546682
128Hepatitis C_Homo sapiens_hsa051600.28244355
129Selenocompound metabolism_Homo sapiens_hsa004500.27609718
130Lysine degradation_Homo sapiens_hsa003100.26910519
131Osteoclast differentiation_Homo sapiens_hsa043800.26667508
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.25402754
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.25067868
134Pathways in cancer_Homo sapiens_hsa052000.24593886
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.23112840
136Chemokine signaling pathway_Homo sapiens_hsa040620.21580527
137Viral myocarditis_Homo sapiens_hsa054160.19386618
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19227192
139Toxoplasmosis_Homo sapiens_hsa051450.18829693
140VEGF signaling pathway_Homo sapiens_hsa043700.18717781
141Endocytosis_Homo sapiens_hsa041440.17184705
142MAPK signaling pathway_Homo sapiens_hsa040100.16723912
143Prostate cancer_Homo sapiens_hsa052150.16306754
144HIF-1 signaling pathway_Homo sapiens_hsa040660.16299338
145Renal cell carcinoma_Homo sapiens_hsa052110.16186457
146ErbB signaling pathway_Homo sapiens_hsa040120.14887450
147Fructose and mannose metabolism_Homo sapiens_hsa000510.14843598

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