VPREB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell apoptotic process (GO:0002903)7.58844034
2negative regulation of thymocyte apoptotic process (GO:0070244)7.51245183
3purine deoxyribonucleotide catabolic process (GO:0009155)6.54619028
4V(D)J recombination (GO:0033151)6.46359505
5purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)6.09875315
6B cell receptor signaling pathway (GO:0050853)6.09075536
7regulation of histone H3-K9 methylation (GO:0051570)5.91632587
8natural killer cell differentiation (GO:0001779)5.67581795
9DNA unwinding involved in DNA replication (GO:0006268)5.64029888
10L-serine transport (GO:0015825)5.61309124
11response to vitamin E (GO:0033197)5.57655588
12autophagic vacuole fusion (GO:0000046)5.54760548
13deoxyribonucleotide catabolic process (GO:0009264)5.45573030
14positive regulation by host of viral transcription (GO:0043923)5.43575699
15regulation of penile erection (GO:0060405)5.41943786
16serine transport (GO:0032329)5.33477460
17positive regulation of B cell differentiation (GO:0045579)5.30792997
18regulation of B cell apoptotic process (GO:0002902)5.29528879
19regulation of NFAT protein import into nucleus (GO:0051532)5.28967596
20organelle membrane fusion (GO:0090174)5.21107983
21purine nucleotide salvage (GO:0032261)5.20813896
22negative regulation of histone methylation (GO:0031061)5.20538086
23deoxyribose phosphate catabolic process (GO:0046386)5.10669632
24ether lipid metabolic process (GO:0046485)5.09241684
25regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.04442116
26protein localization to kinetochore (GO:0034501)4.95411510
27DNA topological change (GO:0006265)4.90299956
28nucleotide salvage (GO:0043173)4.88991017
29cellular extravasation (GO:0045123)4.88461680
30histamine secretion (GO:0001821)4.84179703
31ribosomal small subunit assembly (GO:0000028)4.84113044
32regulation of oxidative stress-induced neuron death (GO:1903203)4.76773462
33deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.74309509
34regulation of thymocyte apoptotic process (GO:0070243)4.65954171
35nucleosome disassembly (GO:0006337)4.57370415
36protein-DNA complex disassembly (GO:0032986)4.57370415
37detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.56430354
38tachykinin receptor signaling pathway (GO:0007217)4.54211578
39purine deoxyribonucleotide metabolic process (GO:0009151)4.52708499
40positive regulation of histone deacetylation (GO:0031065)4.48370998
41negative regulation of T-helper cell differentiation (GO:0045623)4.48035339
42negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.48035339
43cellular hyperosmotic response (GO:0071474)4.45410491
44vesicle targeting (GO:0006903)4.45293972
45negative regulation of cell size (GO:0045792)4.44549904
46positive regulation of granulocyte differentiation (GO:0030854)4.41795875
47negative regulation of phagocytosis (GO:0050765)4.35164041
48regulation of T-helper 1 cell differentiation (GO:0045625)4.25199060
49protein localization to chromosome, centromeric region (GO:0071459)4.20895316
50regulation of germinal center formation (GO:0002634)4.18595743
51positive regulation of T cell differentiation in thymus (GO:0033089)4.13233005
52mature B cell differentiation involved in immune response (GO:0002313)4.09142341
53negative regulation of lymphocyte apoptotic process (GO:0070229)4.08600226
54negative regulation of T cell apoptotic process (GO:0070233)4.01711552
55chaperone mediated protein folding requiring cofactor (GO:0051085)3.98808585
56Peyers patch development (GO:0048541)3.98783856
57mucosal-associated lymphoid tissue development (GO:0048537)3.98783856
58viral transcription (GO:0019083)3.96193312
59positive regulation of lamellipodium assembly (GO:0010592)3.91282799
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.90757095
61sister chromatid segregation (GO:0000819)3.89790493
62glycerol ether metabolic process (GO:0006662)3.87080479
63immunoglobulin mediated immune response (GO:0016064)3.82941417
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.82750365
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.82750365
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.80915261
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.80915261
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.80915261
69mitotic sister chromatid cohesion (GO:0007064)3.80641578
70detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.79162759
71histamine transport (GO:0051608)3.78890834
72deoxyribose phosphate metabolic process (GO:0019692)3.75050752
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72625999
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.72462136
75translational termination (GO:0006415)3.72229164
76mast cell activation involved in immune response (GO:0002279)3.71793205
77mast cell degranulation (GO:0043303)3.71793205
782-deoxyribonucleotide metabolic process (GO:0009394)3.69525227
79regulation of cellular amino acid metabolic process (GO:0006521)3.68354526
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.66473498
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.66473498
82negative regulation of bone resorption (GO:0045779)3.65047298
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63747143
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62601255
85regulation of dendritic cell antigen processing and presentation (GO:0002604)3.61363603
86lens fiber cell development (GO:0070307)3.61294506
87B cell proliferation (GO:0042100)3.61019391
88positive regulation of vascular permeability (GO:0043117)3.60808350
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.59468490
90regulation of granulocyte differentiation (GO:0030852)3.59401487
91DNA strand elongation involved in DNA replication (GO:0006271)3.59118764
92T cell homeostasis (GO:0043029)3.58914941
93ether metabolic process (GO:0018904)3.58903170
94negative regulation of RNA splicing (GO:0033119)3.58518760
95positive regulation of gamma-delta T cell activation (GO:0046645)3.58018821
96regulation of extracellular matrix disassembly (GO:0010715)3.54317970
97lysosome localization (GO:0032418)3.53053319
98positive regulation of chromosome segregation (GO:0051984)3.51220336
99pseudouridine synthesis (GO:0001522)3.51176931
100translational elongation (GO:0006414)3.49120905
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47574007
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46671983
103antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46671983
104purine-containing compound salvage (GO:0043101)3.45693980
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45441031
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41639905
107positive regulation of protein deacetylation (GO:0090312)3.39942900
108DNA strand elongation (GO:0022616)3.39801741
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38349397
110deoxyribonucleotide metabolic process (GO:0009262)3.38153097
111hepatocyte apoptotic process (GO:0097284)3.37861062
112mitotic sister chromatid segregation (GO:0000070)3.37687125
113B cell mediated immunity (GO:0019724)3.37520811
114positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.36968250
115DNA deamination (GO:0045006)3.35928831
116telomere maintenance via semi-conservative replication (GO:0032201)3.34952374
117positive regulation of prostaglandin secretion (GO:0032308)3.34342161
118alternative mRNA splicing, via spliceosome (GO:0000380)3.34031177
119regulation of type 2 immune response (GO:0002828)3.32901570
120purinergic nucleotide receptor signaling pathway (GO:0035590)3.32675641
121negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31024759
122negative regulation of ligase activity (GO:0051352)3.31024759
123adaptation of signaling pathway (GO:0023058)3.30542393
124regulation of B cell differentiation (GO:0045577)3.30136692
125positive regulation of antigen processing and presentation (GO:0002579)3.29948123
126negative regulation of gene expression, epigenetic (GO:0045814)3.29225805
127ribosomal small subunit biogenesis (GO:0042274)3.29154639
128somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.28998294
129somatic cell DNA recombination (GO:0016444)3.28998294
130regulation of T cell apoptotic process (GO:0070232)3.28120251
131DNA integration (GO:0015074)3.26980195
132establishment of integrated proviral latency (GO:0075713)3.24055401
133G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.23629300
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23603455
135nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20930595
136protein complex disassembly (GO:0043241)3.20598922
137positive regulation of ligase activity (GO:0051351)3.20553966
138pyrimidine nucleoside salvage (GO:0043097)3.19974260
139pyrimidine-containing compound salvage (GO:0008655)3.19974260
140positive regulation of Rap GTPase activity (GO:0032854)3.18491961
141mitotic recombination (GO:0006312)3.18489039
142lymphocyte homeostasis (GO:0002260)3.18197028
143regulation of T-helper 2 cell differentiation (GO:0045628)3.18169831
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17956920
145negative regulation of alpha-beta T cell differentiation (GO:0046639)3.16694066
146antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15212216
147positive thymic T cell selection (GO:0045059)3.15026944
148DNA ligation (GO:0006266)3.14748592
149positive regulation of lamellipodium organization (GO:1902745)3.13567356
150regulation of histone methylation (GO:0031060)3.13502117
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10060922
152protein localization to chromosome (GO:0034502)3.09383729
153regulation of lymphocyte apoptotic process (GO:0070228)3.08475872
154modulation by host of symbiont transcription (GO:0052472)3.08216284
155modulation by host of viral transcription (GO:0043921)3.08216284
156mast cell activation (GO:0045576)3.05048368
157pyrimidine nucleotide catabolic process (GO:0006244)3.05028828
158translesion synthesis (GO:0019985)3.04797021
159dosage compensation (GO:0007549)3.04624577
160B cell differentiation (GO:0030183)3.03863562
161regulation of DNA endoreduplication (GO:0032875)3.03694177
162positive regulation of cellular response to oxidative stress (GO:1900409)3.03005639
163positive regulation of response to oxidative stress (GO:1902884)3.03005639
164somatic diversification of immune receptors (GO:0002200)3.02848653
165determination of adult lifespan (GO:0008340)3.02814548
166L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02400172
167negative regulation of granulocyte differentiation (GO:0030853)3.02171050
168adenosine metabolic process (GO:0046085)3.02028927
169mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00898386
170mitochondrial respiratory chain complex I assembly (GO:0032981)3.00898386
171NADH dehydrogenase complex assembly (GO:0010257)3.00898386
172cellular protein complex disassembly (GO:0043624)3.00784923
173ATP-dependent chromatin remodeling (GO:0043044)3.00510995
174germ cell migration (GO:0008354)2.99660986
175positive regulation of transcription regulatory region DNA binding (GO:2000679)2.98955093
176positive regulation of type 2 immune response (GO:0002830)2.98840297
177SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97945534
178negative regulation of T cell differentiation (GO:0045581)2.97150669
179pentose-phosphate shunt (GO:0006098)2.96128070
180chromatin silencing (GO:0006342)2.95365770
181mitotic chromosome condensation (GO:0007076)2.94224803
182cotranslational protein targeting to membrane (GO:0006613)2.93854027
183base-excision repair, AP site formation (GO:0006285)2.93682145
184DNA duplex unwinding (GO:0032508)2.92499391
185cGMP-mediated signaling (GO:0019934)2.91432903
186viral life cycle (GO:0019058)2.91088485
187protein targeting to ER (GO:0045047)2.91082371
188telomere maintenance via recombination (GO:0000722)2.90619647
189macromolecular complex disassembly (GO:0032984)2.89720155
190DNA geometric change (GO:0032392)2.88926663
191leukocyte homeostasis (GO:0001776)2.88826833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.14826216
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.66274563
3MYC_22102868_ChIP-Seq_BL_Human5.04046236
4VDR_21846776_ChIP-Seq_THP-1_Human3.45423666
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43794237
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.19807878
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15656989
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03649966
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87205907
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.79475961
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78820854
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.65693723
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.60726739
14SCL_19346495_ChIP-Seq_HPC-7_Human2.60119744
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57393694
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56871424
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54556018
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.51480649
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41312450
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37252292
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.34825139
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31274033
23UTX_26944678_Chip-Seq_JUKART_Human2.29534276
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28182906
25CIITA_25753668_ChIP-Seq_RAJI_Human2.18207785
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.16931313
27VDR_24763502_ChIP-Seq_THP-1_Human2.15951023
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10946866
29TCF7_22412390_ChIP-Seq_EML_Mouse2.08116775
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05768396
31MYB_26560356_Chip-Seq_TH2_Human2.05172917
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03977527
33MAF_26560356_Chip-Seq_TH1_Human2.01244013
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00297114
35E2F7_22180533_ChIP-Seq_HELA_Human10.1397188
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98769705
37MYB_26560356_Chip-Seq_TH1_Human1.96078937
38KDM2B_26808549_Chip-Seq_DND41_Human1.84396880
39IRF1_19129219_ChIP-ChIP_H3396_Human1.83245530
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.81535106
41BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.80741187
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74361398
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.74177925
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70495028
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.70361013
46* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64433093
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64226489
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.63423455
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62907457
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60730646
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60601395
52* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60297852
53GATA1_22025678_ChIP-Seq_K562_Human1.58949559
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57672636
55AR_21909140_ChIP-Seq_LNCAP_Human1.55494680
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.53605753
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53386285
58* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49425187
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48915632
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48612161
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.45062230
62SPI1_23127762_ChIP-Seq_K562_Human1.45035886
63MYC_18940864_ChIP-ChIP_HL60_Human1.44515646
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44269580
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.44046896
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.43620293
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43221478
68* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42753227
69XRN2_22483619_ChIP-Seq_HELA_Human1.40651442
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39698597
71SPI1_23547873_ChIP-Seq_NB4_Human1.37459327
72* RUNX_20019798_ChIP-Seq_JUKART_Human1.37079432
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35971486
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.35876634
75GABP_19822575_ChIP-Seq_HepG2_Human1.34497541
76MAF_26560356_Chip-Seq_TH2_Human1.33898021
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33616338
78BCL6_27268052_Chip-Seq_Bcells_Human1.33430658
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33362360
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29792767
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29626750
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28918420
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.28801606
84FOXP3_21729870_ChIP-Seq_TREG_Human1.28486608
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28027771
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25869784
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25342634
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24610776
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23673815
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22714148
91P300_27268052_Chip-Seq_Bcells_Human1.22614867
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22114950
93ELK1_19687146_ChIP-ChIP_HELA_Human1.20926850
94E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19275282
95ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18763304
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18436512
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17362718
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16885432
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15767765
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15341839
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15112660
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15106881
103KDM5A_27292631_Chip-Seq_BREAST_Human1.14265361
104EZH2_22144423_ChIP-Seq_EOC_Human1.13579376
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12894957
106IRF8_27001747_Chip-Seq_BMDM_Mouse1.12279859
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11776455
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11521924
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11047094
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10390735
111* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09731582
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.09719394
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09716656
114MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06434288
115* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04780411
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02182876
117VDR_24787735_ChIP-Seq_THP-1_Human1.01398997
118SPI1_20517297_ChIP-Seq_HL60_Human1.01056704
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00262721
120GATA3_26560356_Chip-Seq_TH2_Human0.99464171
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98063616
122VDR_23849224_ChIP-Seq_CD4+_Human0.97199879
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95665999
124STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95072213
125STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93657812
126BCOR_27268052_Chip-Seq_Bcells_Human0.93629773
127* GATA3_27048872_Chip-Seq_THYMUS_Human0.88975894
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88392424
129* NCOR1_26117541_ChIP-Seq_K562_Human0.87139880
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87106513
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85661916
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85601996
133EST1_17652178_ChIP-ChIP_JURKAT_Human0.85197436
134* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85120309
135TTF2_22483619_ChIP-Seq_HELA_Human0.85076028
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84917311
137E2F1_20622854_ChIP-Seq_HELA_Human0.84860436
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84532777
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84431417
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82783882
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82525497
142CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82149631
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80915331
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78307961
145FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.76953531
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.76926227
147KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75957689
148TFEB_21752829_ChIP-Seq_HELA_Human0.75082539
149CHD1_26751641_Chip-Seq_LNCaP_Human0.74867952
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74740834
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73927638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.62556240
2MP0009697_abnormal_copulation4.08484657
3MP0002396_abnormal_hematopoietic_system3.75077935
4MP0009278_abnormal_bone_marrow3.59743167
5MP0003252_abnormal_bile_duct3.42793212
6* MP0001800_abnormal_humoral_immune3.19116014
7MP0010094_abnormal_chromosome_stability3.14891099
8MP0004808_abnormal_hematopoietic_stem3.09473113
9MP0003646_muscle_fatigue3.03408037
10MP0002653_abnormal_ependyma_morphology3.02937495
11MP0000685_abnormal_immune_system2.91818326
12MP0005083_abnormal_biliary_tract2.87938393
13* MP0002398_abnormal_bone_marrow2.78415862
14MP0004233_abnormal_muscle_weight2.65023329
15MP0002148_abnormal_hypersensitivity_rea2.54011977
16* MP0000689_abnormal_spleen_morphology2.51950352
17MP0000703_abnormal_thymus_morphology2.50299036
18MP0002722_abnormal_immune_system2.48395560
19MP0005645_abnormal_hypothalamus_physiol2.44862701
20* MP0002452_abnormal_antigen_presenting2.42966946
21MP0003111_abnormal_nucleus_morphology2.37012000
22MP0003077_abnormal_cell_cycle2.30637649
23MP0003436_decreased_susceptibility_to2.27360941
24MP0005397_hematopoietic_system_phenotyp2.25923370
25MP0001545_abnormal_hematopoietic_system2.25923370
26MP0003303_peritoneal_inflammation2.25569094
27* MP0000716_abnormal_immune_system2.22845717
28MP0008057_abnormal_DNA_replication2.22335281
29MP0003693_abnormal_embryo_hatching2.20863870
30MP0004957_abnormal_blastocyst_morpholog2.13789609
31MP0001790_abnormal_immune_system2.11936513
32MP0005387_immune_system_phenotype2.11936513
33* MP0002420_abnormal_adaptive_immunity2.09323955
34MP0010352_gastrointestinal_tract_polyps2.06912097
35* MP0001819_abnormal_immune_cell2.05974307
36MP0003300_gastrointestinal_ulcer2.04380549
37* MP0002723_abnormal_immune_serum2.03348345
38MP0000490_abnormal_crypts_of2.02856081
39MP0010307_abnormal_tumor_latency2.02198043
40* MP0002429_abnormal_blood_cell1.90572960
41MP0001661_extended_life_span1.90090694
42MP0002019_abnormal_tumor_incidence1.87316400
43MP0001835_abnormal_antigen_presentation1.82482626
44MP0005464_abnormal_platelet_physiology1.82320480
45MP0009785_altered_susceptibility_to1.81088642
46MP0003763_abnormal_thymus_physiology1.75290503
47MP0005000_abnormal_immune_tolerance1.74315033
48MP0005671_abnormal_response_to1.67417343
49MP0005084_abnormal_gallbladder_morpholo1.67021810
50MP0006054_spinal_hemorrhage1.64653291
51MP0005075_abnormal_melanosome_morpholog1.62424194
52MP0004147_increased_porphyrin_level1.62089561
53MP0002132_abnormal_respiratory_system1.61346795
54MP0000372_irregular_coat_pigmentation1.60099696
55MP0002166_altered_tumor_susceptibility1.53881907
56MP0004947_skin_inflammation1.52050323
57MP0005220_abnormal_exocrine_pancreas1.49288823
58MP0010155_abnormal_intestine_physiology1.48673780
59MP0009764_decreased_sensitivity_to1.47642578
60MP0010234_abnormal_vibrissa_follicle1.47431450
61MP0001730_embryonic_growth_arrest1.46424306
62MP0003806_abnormal_nucleotide_metabolis1.43169539
63MP0009333_abnormal_splenocyte_physiolog1.39221175
64MP0005076_abnormal_cell_differentiation1.39200018
65MP0003724_increased_susceptibility_to1.37477320
66MP0003950_abnormal_plasma_membrane1.34790111
67MP0008007_abnormal_cellular_replicative1.30044817
68MP0000350_abnormal_cell_proliferation1.29203521
69MP0008872_abnormal_physiological_respon1.28397504
70MP0001177_atelectasis1.28309645
71MP0005025_abnormal_response_to1.26577019
72MP0008058_abnormal_DNA_repair1.26543974
73MP0008875_abnormal_xenobiotic_pharmacok1.26274610
74MP0001905_abnormal_dopamine_level1.23713567
75MP0002405_respiratory_system_inflammati1.20804023
76MP0006292_abnormal_olfactory_placode1.20610583
77MP0008961_abnormal_basal_metabolism1.13178033
78MP0002837_dystrophic_cardiac_calcinosis1.09885429
79MP0003191_abnormal_cellular_cholesterol1.09727117
80MP0006072_abnormal_retinal_apoptosis1.08297492
81MP0008877_abnormal_DNA_methylation1.07393625
82MP0001881_abnormal_mammary_gland1.06820537
83MP0004782_abnormal_surfactant_physiolog1.02961750
84MP0002139_abnormal_hepatobiliary_system1.02695066
85MP0001984_abnormal_olfaction1.02485929
86MP0002876_abnormal_thyroid_physiology1.01812905
87MP0001915_intracranial_hemorrhage1.01585463
88MP0003283_abnormal_digestive_organ1.01358852
89MP0000613_abnormal_salivary_gland0.99247084
90MP0000313_abnormal_cell_death0.99032286
91MP0001968_abnormal_touch/_nociception0.96492778
92MP0008775_abnormal_heart_ventricle0.95827913
93MP0001879_abnormal_lymphatic_vessel0.95628431
94MP0002419_abnormal_innate_immunity0.95414959
95MP0000230_abnormal_systemic_arterial0.92895548
96MP0003984_embryonic_growth_retardation0.92396646
97MP0003866_abnormal_defecation0.88094493
98MP0002006_tumorigenesis0.87993758
99MP0002080_prenatal_lethality0.87796333
100MP0003786_premature_aging0.87784353
101MP0002970_abnormal_white_adipose0.87705996
102MP0002088_abnormal_embryonic_growth/wei0.86053354
103MP0001533_abnormal_skeleton_physiology0.86050736
104MP0001672_abnormal_embryogenesis/_devel0.85652905
105MP0005380_embryogenesis_phenotype0.85652905
106MP0001873_stomach_inflammation0.85279909
107MP0001845_abnormal_inflammatory_respons0.83931008
108MP0005166_decreased_susceptibility_to0.82272915
109MP0005389_reproductive_system_phenotype0.81903913
110MP0000477_abnormal_intestine_morphology0.79166576
111MP0000465_gastrointestinal_hemorrhage0.79155800
112MP0006276_abnormal_autonomic_nervous0.78883937
113MP0005266_abnormal_metabolism0.77384382
114MP0005501_abnormal_skin_physiology0.76957600
115MP0004197_abnormal_fetal_growth/weight/0.76723566
116MP0001697_abnormal_embryo_size0.75371786
117MP0008932_abnormal_embryonic_tissue0.73399208
118MP0009780_abnormal_chondrocyte_physiolo0.73099945
119MP0000427_abnormal_hair_cycle0.72652307
120MP0002127_abnormal_cardiovascular_syste0.71482223
121MP0003943_abnormal_hepatobiliary_system0.70822006
122MP0005410_abnormal_fertilization0.69837876
123MP0002160_abnormal_reproductive_system0.69515128
124MP0003566_abnormal_cell_adhesion0.69423673
125MP0009931_abnormal_skin_appearance0.68957524
126MP0008874_decreased_physiological_sensi0.68576474
127MP0002733_abnormal_thermal_nociception0.68195569
128MP0002086_abnormal_extraembryonic_tissu0.66859948
129MP0000377_abnormal_hair_follicle0.66286952
130MP0001919_abnormal_reproductive_system0.66178083
131MP0005584_abnormal_enzyme/coenzyme_acti0.64584092
132MP0008469_abnormal_protein_level0.64345007
133MP0002822_catalepsy0.63588419
134MP0003315_abnormal_perineum_morphology0.62534079
135MP0005409_darkened_coat_color0.61873216
136MP0009765_abnormal_xenobiotic_induced0.61224215
137MP0003787_abnormal_imprinting0.60534222
138MP0008873_increased_physiological_sensi0.60043045
139MP0008770_decreased_survivor_rate0.60039989
140MP0004036_abnormal_muscle_relaxation0.57619198
141MP0002083_premature_death0.57566618
142MP0005621_abnormal_cell_physiology0.56966839
143MP0001243_abnormal_dermal_layer0.56683756
144MP0001929_abnormal_gametogenesis0.56637192
145MP0005058_abnormal_lysosome_morphology0.56602303
146MP0003705_abnormal_hypodermis_morpholog0.56036497
147MP0002282_abnormal_trachea_morphology0.55992546
148MP0001727_abnormal_embryo_implantation0.54738067
149MP0003091_abnormal_cell_migration0.54118295
150MP0002085_abnormal_embryonic_tissue0.53156141
151MP0001853_heart_inflammation0.52758773

Predicted human phenotypes

RankGene SetZ-score
1Papilloma (HP:0012740)8.76840406
2Verrucae (HP:0200043)8.76840406
3Osteomyelitis (HP:0002754)5.90618229
4Chronic sinusitis (HP:0011109)5.77199795
5Thyroiditis (HP:0100646)5.57190019
6Meningitis (HP:0001287)5.38222127
7Small epiphyses (HP:0010585)5.28423008
8Sepsis (HP:0100806)4.99726549
9Recurrent pneumonia (HP:0006532)4.95244547
10B lymphocytopenia (HP:0010976)4.86414734
11Abnormality of B cell number (HP:0010975)4.86414734
12Vertebral arch anomaly (HP:0008438)4.53918728
13Panhypogammaglobulinemia (HP:0003139)4.22870355
14Recurrent bronchitis (HP:0002837)4.14311092
15Recurrent lower respiratory tract infections (HP:0002783)4.01507644
16Mesangial abnormality (HP:0001966)3.99090572
17Abnormality of the intervertebral disk (HP:0005108)3.94803148
18Recurrent viral infections (HP:0004429)3.93621856
19Hypoplasia of the capital femoral epiphysis (HP:0003090)3.77066943
20Skin rash (HP:0000988)3.69056118
21Severe combined immunodeficiency (HP:0004430)3.46599750
22Autoimmune hemolytic anemia (HP:0001890)3.35977665
23Flattened epiphyses (HP:0003071)3.28220636
24Recurrent otitis media (HP:0000403)3.27492874
25Hypoplasia of the thymus (HP:0000778)3.25161649
26Combined immunodeficiency (HP:0005387)3.20188331
27IgM deficiency (HP:0002850)3.19967352
28Abnormal mitochondria in muscle tissue (HP:0008316)3.18298297
29Acute necrotizing encephalopathy (HP:0006965)3.16369917
30Mitral stenosis (HP:0001718)3.15387166
31Chronic otitis media (HP:0000389)3.15357004
32Ulnar bowing (HP:0003031)3.10317430
33Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.05043181
34Absent epiphyses (HP:0010577)3.05043181
35Gastrointestinal inflammation (HP:0004386)2.95048726
36Hepatocellular necrosis (HP:0001404)2.94431511
37Dehydration (HP:0001944)2.94092237
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.93224894
39Autoimmune thrombocytopenia (HP:0001973)2.90673626
40Abnormality of the fingertips (HP:0001211)2.83649762
41Hepatic necrosis (HP:0002605)2.80184472
42Cutaneous melanoma (HP:0012056)2.79180390
43Acute encephalopathy (HP:0006846)2.78929369
44T lymphocytopenia (HP:0005403)2.76023453
45Colitis (HP:0002583)2.74386455
46Arthropathy (HP:0003040)2.72165282
47Inflammation of the large intestine (HP:0002037)2.65304121
48Progressive macrocephaly (HP:0004481)2.65168507
49Mitochondrial inheritance (HP:0001427)2.60985747
50Abnormality of T cell number (HP:0011839)2.52615585
51External ear malformation (HP:0008572)2.50774090
52Increased CSF lactate (HP:0002490)2.49418516
53Aplasia/hypoplasia of the humerus (HP:0006507)2.40568865
54Leukocytosis (HP:0001974)2.39623196
55Aplastic anemia (HP:0001915)2.38340098
56Cerebral palsy (HP:0100021)2.38308251
57Abnormality of T cells (HP:0002843)2.33548744
58Delayed CNS myelination (HP:0002188)2.32576584
59Neutropenia (HP:0001875)2.32273090
60Vertebral clefting (HP:0008428)2.32035624
61Colon cancer (HP:0003003)2.29935524
62Cerebral edema (HP:0002181)2.28718225
63Medulloblastoma (HP:0002885)2.27119175
64Irregular vertebral endplates (HP:0003301)2.25715349
65Recurrent fungal infections (HP:0002841)2.23990799
66Fibular aplasia (HP:0002990)2.23384573
67Bronchitis (HP:0012387)2.22728985
68Skin ulcer (HP:0200042)2.22069632
69Limited elbow extension (HP:0001377)2.21267658
70Cutis marmorata (HP:0000965)2.21111409
71Reticulocytopenia (HP:0001896)2.17565350
72Ependymoma (HP:0002888)2.15428415
73Acute lymphatic leukemia (HP:0006721)2.14149269
74Cupped ribs (HP:0000887)2.12102816
75Volvulus (HP:0002580)2.11404724
76Aplasia/Hypoplasia of the thymus (HP:0010515)2.09432080
77Long eyelashes (HP:0000527)2.09224895
78Hypoproteinemia (HP:0003075)2.08945879
79Metaphyseal cupping (HP:0003021)2.07175643
80Elevated erythrocyte sedimentation rate (HP:0003565)2.07128782
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.05242591
82Lymphopenia (HP:0001888)2.03899234
83Abnormality of T cell physiology (HP:0011840)2.02174786
84Agammaglobulinemia (HP:0004432)12.7530057
85Cellulitis (HP:0100658)10.3187272
86Abnormality of the thymus (HP:0000777)1.99364035
87Microvesicular hepatic steatosis (HP:0001414)1.99289466
88Type 2 muscle fiber atrophy (HP:0003554)1.94964239
89Abnormality of cells of the erythroid lineage (HP:0012130)1.93890745
90Barrel-shaped chest (HP:0001552)1.93067514
91Abnormal number of erythroid precursors (HP:0012131)1.90321948
92Abnormal rod and cone electroretinograms (HP:0008323)1.88717668
93Thrombocytosis (HP:0001894)1.88069014
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86946467
95Recurrent sinusitis (HP:0011108)1.84870840
96Ankyloglossia (HP:0010296)1.84722174
97Spontaneous hematomas (HP:0007420)1.83503940
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.83304037
99Eosinophilia (HP:0001880)1.82457609
100Increased intramyocellular lipid droplets (HP:0012240)1.82325618
101Increased density of long bones (HP:0006392)1.80963143
102Lactic acidosis (HP:0003128)1.80707539
103Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77721195
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77721195
105Memory impairment (HP:0002354)1.77704843
106Short humerus (HP:0005792)1.77590812
107IgG deficiency (HP:0004315)1.76868309
108Abnormality of endocrine pancreas physiology (HP:0012093)1.76322296
109Abnormality of the pancreatic islet cells (HP:0006476)1.76322296
110Muscle fiber atrophy (HP:0100295)1.73670383
111Patellar aplasia (HP:0006443)1.72828679
112Palpitations (HP:0001962)1.72445719
113Chronic mucocutaneous candidiasis (HP:0002728)1.71861836
114Recurrent cutaneous fungal infections (HP:0011370)1.71861836
115Bowing of the arm (HP:0006488)1.71358139
116Bowed forearm bones (HP:0003956)1.71358139
117Erythroderma (HP:0001019)1.70440250
118Lymphoma (HP:0002665)1.69483737
119Generalized aminoaciduria (HP:0002909)1.68260520
120Aortic regurgitation (HP:0001659)1.67237333
121Abnormality of the tricuspid valve (HP:0001702)1.67096541
122Tubulointerstitial nephritis (HP:0001970)1.66664328
123Orthostatic hypotension (HP:0001278)1.65923894
124Abnormality of the vertebral endplates (HP:0005106)1.65116723
125Synostosis involving the elbow (HP:0003938)1.62862873
126Humeroradial synostosis (HP:0003041)1.62862873
127Neoplasm of the adrenal cortex (HP:0100641)1.62775837
128Prolonged bleeding time (HP:0003010)1.61479537
129CNS demyelination (HP:0007305)1.61092455
130Hypergammaglobulinemia (HP:0010702)1.58875182
131Granulocytopenia (HP:0001913)1.58469031
132Testicular atrophy (HP:0000029)1.56607193
133Pustule (HP:0200039)1.56604646
134Delusions (HP:0000746)1.54342961
135Abnormality of chromosome segregation (HP:0002916)1.54046706
136Aplasia/Hypoplasia of the patella (HP:0006498)1.53543603
137Abnormality of subcutaneous fat tissue (HP:0001001)1.53493611
138Abnormality of the prostate (HP:0008775)1.52757481
139Posterior subcapsular cataract (HP:0007787)1.51772052
140Facial diplegia (HP:0001349)1.51553120
141Dysautonomia (HP:0002459)1.51307217
142Hepatosplenomegaly (HP:0001433)1.50979882
143Dry hair (HP:0011359)1.50078414
144Meckel diverticulum (HP:0002245)1.49978757
145Attenuation of retinal blood vessels (HP:0007843)1.49566587
146Asymmetry of the thorax (HP:0001555)1.49284815
147Pancreatic cysts (HP:0001737)1.49163913
148Abnormality of the pleura (HP:0002103)1.47736454
149Squamous cell carcinoma (HP:0002860)1.46300629
150Hematochezia (HP:0002573)1.43287760
151Interstitial pulmonary disease (HP:0006530)1.42420270
152Abnormality of eosinophils (HP:0001879)1.40490952
153Enlarged penis (HP:0000040)1.39218222
154Increased IgE level (HP:0003212)1.36911397
155Hyperacusis (HP:0010780)1.36836471
156Papilledema (HP:0001085)1.36172210
157Increased nuchal translucency (HP:0010880)1.35918922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K107.48414691
2EEF2K7.32119937
3KIT6.27961362
4VRK25.10313838
5BCKDK3.14921614
6NME23.13031325
7KDR2.85489701
8ERN12.83674730
9PKN22.75528059
10PLK22.52001826
11SIK22.45704583
12RPS6KB22.28699933
13NEK22.26947402
14SRPK12.25758884
15NUAK12.25436882
16GRK62.09348570
17CLK12.09158808
18SYK1.95873002
19MAP4K11.77609550
20FGFR21.72684935
21STK41.71270124
22CDK191.70369136
23STK101.69496331
24ARAF1.69444986
25CDC71.63127288
26MAPK111.60275910
27FES1.57077719
28DAPK11.55020668
29MAPK121.54623720
30MAPKAPK31.53373162
31BTK1.49527392
32PRKCI1.49249737
33TRIB31.48023878
34LRRK21.47148276
35CSF1R1.46373053
36CDK41.44345010
37VRK11.41739652
38MAP3K111.37768802
39PASK1.36803921
40CDK121.32435365
41SCYL21.32289383
42CDK81.31653859
43SIK11.30498491
44NLK1.26718966
45TESK21.23771813
46BMPR1B1.21012726
47FRK1.20399551
48RIPK11.17847911
49HCK1.16608999
50MAPK131.13820486
51BUB11.13700219
52ABL21.06791802
53RPS6KB11.01202756
54RIPK40.97968500
55ZAK0.97528585
56MAPK40.96482996
57PIM10.92989211
58TGFBR10.88187266
59MAP3K70.86780037
60PBK0.86259487
61HIPK20.81002762
62TNK20.78453048
63CDK60.76595502
64FLT30.76574409
65TRPM70.75873353
66GRK10.75499913
67TTK0.75387989
68INSRR0.74467419
69LYN0.73488730
70PDK20.73400523
71CSNK1G30.72980092
72MAP3K80.72425397
73MAP4K20.71560725
74FGFR30.70650469
75TLK10.68030065
76PHKG10.67665443
77PHKG20.67665443
78EIF2AK20.64218199
79ADRBK20.62879448
80ATR0.61841110
81DYRK20.60970679
82ITK0.60727991
83UHMK10.58914186
84PRKCH0.56931319
85TYK20.56892739
86WEE10.53596374
87STK30.52577166
88MARK20.52265972
89TESK10.48780309
90BCR0.48775775
91TAF10.48718772
92MAP3K60.48564484
93EIF2AK30.48270923
94LCK0.48055487
95MAPKAPK50.47785057
96BLK0.47275697
97CSNK1G10.46592157
98CDK140.46368073
99DYRK1B0.44495981
100EPHA20.43126585
101BRD40.43089512
102PAK20.42683185
103MTOR0.42244735
104CHEK10.41562014
105IGF1R0.41505967
106MELK0.41448489
107CDK20.39766590
108MAPKAPK20.39491194
109AURKB0.39471322
110PRKCE0.39424711
111ALK0.38736148
112ACVR1B0.38465416
113MST40.37815155
114PDK10.37548110
115CSNK1G20.36391253
116AKT20.36354347
117TIE10.36181400
118CSNK1A10.35565687
119PIM20.35507775
120PTK60.34208525
121ZAP700.33919044
122DYRK30.33540117
123RPS6KA50.33509787
124TEC0.32754661
125PRKCQ0.32528743
126ICK0.32190685
127IKBKB0.31954085
128IRAK30.31830315
129RPS6KA10.31657815
130EIF2AK10.31487363
131OXSR10.31085991
132CSNK2A10.31031625
133CCNB10.29436374
134BMX0.29427485
135CHUK0.28524711
136BRSK10.28313232
137CDK90.27962518
138CDK11A0.27537227
139RPS6KL10.27386142
140RPS6KC10.27386142
141CDK150.27357543
142MAP2K30.27256519
143STK240.26971117
144RAF10.26862628
145MARK30.26453415
146PRKD20.26074047
147ATM0.25660675
148CSNK1D0.25621766
149NEK10.25568694
150CDK70.25486721
151RPS6KA60.24532822
152JAK30.24451416
153CDK180.24417137
154OBSCN0.24177938
155FGFR40.23654076
156CSNK2A20.23512927
157ABL10.23146693

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.39437415
2Proteasome_Homo sapiens_hsa030505.58749974
3B cell receptor signaling pathway_Homo sapiens_hsa046624.28378100
4Asthma_Homo sapiens_hsa053103.26588524
5DNA replication_Homo sapiens_hsa030303.21967316
6Base excision repair_Homo sapiens_hsa034102.47402175
7Non-homologous end-joining_Homo sapiens_hsa034502.45886711
8Mismatch repair_Homo sapiens_hsa034302.44346756
9Allograft rejection_Homo sapiens_hsa053302.39914513
10Sulfur metabolism_Homo sapiens_hsa009202.34056762
11Autoimmune thyroid disease_Homo sapiens_hsa053202.29045649
12Graft-versus-host disease_Homo sapiens_hsa053322.20959460
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.13583627
14Type I diabetes mellitus_Homo sapiens_hsa049402.07782780
15Cell cycle_Homo sapiens_hsa041102.02225434
16Ribosome_Homo sapiens_hsa030102.00162598
17Non-small cell lung cancer_Homo sapiens_hsa052231.91168075
18Glioma_Homo sapiens_hsa052141.86654505
19Peroxisome_Homo sapiens_hsa041461.84401982
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84099329
21Parkinsons disease_Homo sapiens_hsa050121.79004280
22Oxidative phosphorylation_Homo sapiens_hsa001901.78525368
23Chronic myeloid leukemia_Homo sapiens_hsa052201.77799548
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73598564
25Spliceosome_Homo sapiens_hsa030401.70778893
26mTOR signaling pathway_Homo sapiens_hsa041501.63254435
27Acute myeloid leukemia_Homo sapiens_hsa052211.61444919
28Hematopoietic cell lineage_Homo sapiens_hsa046401.58857360
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.55295893
30Taste transduction_Homo sapiens_hsa047421.49541141
31Osteoclast differentiation_Homo sapiens_hsa043801.37418224
32Homologous recombination_Homo sapiens_hsa034401.32850309
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32177983
34Caffeine metabolism_Homo sapiens_hsa002321.31734364
35One carbon pool by folate_Homo sapiens_hsa006701.27920218
36RNA polymerase_Homo sapiens_hsa030201.27362478
37Staphylococcus aureus infection_Homo sapiens_hsa051501.25057265
38p53 signaling pathway_Homo sapiens_hsa041151.24502081
39mRNA surveillance pathway_Homo sapiens_hsa030151.18152467
40Olfactory transduction_Homo sapiens_hsa047401.14029142
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13601749
42Colorectal cancer_Homo sapiens_hsa052101.12161689
43Viral carcinogenesis_Homo sapiens_hsa052031.11643154
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11626863
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11342160
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.10325252
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10127982
48Pancreatic cancer_Homo sapiens_hsa052121.09906751
49MicroRNAs in cancer_Homo sapiens_hsa052061.09582699
50HIF-1 signaling pathway_Homo sapiens_hsa040661.07143348
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04680197
52Type II diabetes mellitus_Homo sapiens_hsa049301.04611668
53Renin-angiotensin system_Homo sapiens_hsa046141.04410860
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04359204
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04341929
56Inositol phosphate metabolism_Homo sapiens_hsa005621.03417629
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.01324136
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00977418
59Huntingtons disease_Homo sapiens_hsa050161.00650769
60RNA transport_Homo sapiens_hsa030130.99433816
61Nucleotide excision repair_Homo sapiens_hsa034200.98083127
62Measles_Homo sapiens_hsa051620.97824568
63Systemic lupus erythematosus_Homo sapiens_hsa053220.97669812
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97190288
65VEGF signaling pathway_Homo sapiens_hsa043700.94510929
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92778891
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92645743
68HTLV-I infection_Homo sapiens_hsa051660.92174071
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.91342565
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.91264522
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91047738
72Hepatitis B_Homo sapiens_hsa051610.90679454
73ErbB signaling pathway_Homo sapiens_hsa040120.90514038
74Fatty acid elongation_Homo sapiens_hsa000620.90254978
75Purine metabolism_Homo sapiens_hsa002300.90203106
76Viral myocarditis_Homo sapiens_hsa054160.87523185
77Platelet activation_Homo sapiens_hsa046110.86781645
78FoxO signaling pathway_Homo sapiens_hsa040680.86764763
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84375366
80Pentose phosphate pathway_Homo sapiens_hsa000300.83092374
81Prostate cancer_Homo sapiens_hsa052150.81425565
82Rheumatoid arthritis_Homo sapiens_hsa053230.81404598
83Shigellosis_Homo sapiens_hsa051310.80694394
84Small cell lung cancer_Homo sapiens_hsa052220.79300509
85Alzheimers disease_Homo sapiens_hsa050100.78694145
86Insulin resistance_Homo sapiens_hsa049310.76963966
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.76726789
88Epstein-Barr virus infection_Homo sapiens_hsa051690.75967670
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.72309500
90Endometrial cancer_Homo sapiens_hsa052130.70994558
91Regulation of autophagy_Homo sapiens_hsa041400.68990654
92Apoptosis_Homo sapiens_hsa042100.68681288
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68534095
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68217495
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68026612
96Alcoholism_Homo sapiens_hsa050340.67682530
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66695840
98Selenocompound metabolism_Homo sapiens_hsa004500.64827846
99Pyrimidine metabolism_Homo sapiens_hsa002400.64524162
100Tuberculosis_Homo sapiens_hsa051520.64259417
101Lysine degradation_Homo sapiens_hsa003100.64146548
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63560055
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63537091
104Herpes simplex infection_Homo sapiens_hsa051680.63104346
105AMPK signaling pathway_Homo sapiens_hsa041520.63001456
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60938710
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.60406340
108Choline metabolism in cancer_Homo sapiens_hsa052310.58794315
109Cardiac muscle contraction_Homo sapiens_hsa042600.58792030
110Leishmaniasis_Homo sapiens_hsa051400.58153200
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58099828
112Fanconi anemia pathway_Homo sapiens_hsa034600.56952497
113Chemical carcinogenesis_Homo sapiens_hsa052040.56121717
114Chemokine signaling pathway_Homo sapiens_hsa040620.54652195
115T cell receptor signaling pathway_Homo sapiens_hsa046600.53786541
116Nitrogen metabolism_Homo sapiens_hsa009100.53038534
117Sulfur relay system_Homo sapiens_hsa041220.52920174
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52489524
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51371976
120Protein export_Homo sapiens_hsa030600.50794203
121Antigen processing and presentation_Homo sapiens_hsa046120.50477997
122Insulin signaling pathway_Homo sapiens_hsa049100.50273624
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.49735322
124Oocyte meiosis_Homo sapiens_hsa041140.48650929
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48538581
126Proteoglycans in cancer_Homo sapiens_hsa052050.47738192
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44647894
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44010157
129Phototransduction_Homo sapiens_hsa047440.43969853
130Renal cell carcinoma_Homo sapiens_hsa052110.43225152
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43181500
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43161532
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.42902815
134Toxoplasmosis_Homo sapiens_hsa051450.41940655
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41101616
136RNA degradation_Homo sapiens_hsa030180.39628788
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39214902
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38338609
139Arachidonic acid metabolism_Homo sapiens_hsa005900.37326889
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36819189
141Fatty acid metabolism_Homo sapiens_hsa012120.35331964
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34832175
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33444384
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.32949076
145Metabolic pathways_Homo sapiens_hsa011000.32865810
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31635335
147Prolactin signaling pathway_Homo sapiens_hsa049170.31566511
148Influenza A_Homo sapiens_hsa051640.31214169
149Butanoate metabolism_Homo sapiens_hsa006500.31192122
150Legionellosis_Homo sapiens_hsa051340.29641702
151Glutathione metabolism_Homo sapiens_hsa004800.29512047
152Retinol metabolism_Homo sapiens_hsa008300.29331859
153Fatty acid biosynthesis_Homo sapiens_hsa000610.29156249
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29147611
155Thyroid cancer_Homo sapiens_hsa052160.28657542
156Drug metabolism - other enzymes_Homo sapiens_hsa009830.28021878
157alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20453029
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.20413517
159Collecting duct acid secretion_Homo sapiens_hsa049660.20286912
160Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18726210
161Phagosome_Homo sapiens_hsa041450.18550934
162Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16795317
163Pertussis_Homo sapiens_hsa051330.16604376
164Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15665124
165Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15589325
166Other glycan degradation_Homo sapiens_hsa005110.15565514
167Tyrosine metabolism_Homo sapiens_hsa003500.15169110

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