VN2R1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to zinc ion (GO:0071294)8.21532932
2negative regulation of neurotransmitter secretion (GO:0046929)7.79543711
3mesenchymal-epithelial cell signaling (GO:0060638)7.74532117
4positive regulation of macrophage activation (GO:0043032)6.32636686
5negative regulation of stem cell proliferation (GO:2000647)6.32422384
6face development (GO:0060324)6.30441397
7regulation of metalloenzyme activity (GO:0048552)6.15034524
8chondrocyte proliferation (GO:0035988)6.13761324
9cellular response to cadmium ion (GO:0071276)5.93270938
10regulation of integrin-mediated signaling pathway (GO:2001044)5.81306996
11positive regulation of T cell chemotaxis (GO:0010820)5.78364869
12regulation of T cell chemotaxis (GO:0010819)5.78364869
13positive regulation of protein kinase C signaling (GO:0090037)5.68205663
14negative regulation of neurotransmitter transport (GO:0051589)5.63799508
15positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610815.60962515
16anterior/posterior axis specification, embryo (GO:0008595)5.58896946
17regulation of cytokine secretion involved in immune response (GO:0002739)5.57225786
18positive regulation of interleukin-8 secretion (GO:2000484)5.25463859
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.13916461
20positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)5.09381928
21negative regulation of axon extension involved in axon guidance (GO:0048843)5.02467012
22positive regulation of macrophage cytokine production (GO:0060907)5.00964701
23positive regulation of chemokine biosynthetic process (GO:0045080)4.77650437
24midgut development (GO:0007494)4.70855113
25lateral sprouting from an epithelium (GO:0060601)4.70396375
26cartilage condensation (GO:0001502)4.63797172
27cell aggregation (GO:0098743)4.63797172
28regulation of macrophage cytokine production (GO:0010935)4.52307015
29multicellular organism reproduction (GO:0032504)4.45063726
30establishment of tissue polarity (GO:0007164)4.19564947
31establishment of planar polarity (GO:0001736)4.19564947
32regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.18553100
33positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)4.05587282
34sequestering of metal ion (GO:0051238)4.00207544
35regulation of interleukin-8 secretion (GO:2000482)3.97916550
36primitive streak formation (GO:0090009)3.96479277
37uterus development (GO:0060065)3.94125232
38epithelial cell differentiation involved in kidney development (GO:0035850)3.87794008
39NLS-bearing protein import into nucleus (GO:0006607)3.87581310
40negative regulation of axon guidance (GO:1902668)3.87034571
41mammary gland epithelial cell proliferation (GO:0033598)3.86691701
42regulation of chemokine biosynthetic process (GO:0045073)3.83219596
43positive regulation of meiosis (GO:0045836)3.76291124
44regulation of Rac protein signal transduction (GO:0035020)3.76168057
45regulation of protein kinase C signaling (GO:0090036)3.72159675
46zinc ion transport (GO:0006829)3.69103817
47negative regulation of oligodendrocyte differentiation (GO:0048715)3.60543785
48forebrain morphogenesis (GO:0048853)3.56481922
49endothelium development (GO:0003158)3.55747577
50hematopoietic stem cell proliferation (GO:0071425)3.55699107
51zinc ion homeostasis (GO:0055069)3.53883042
52transepithelial transport (GO:0070633)3.52766722
53branching involved in labyrinthine layer morphogenesis (GO:0060670)3.51865034
54vagina development (GO:0060068)3.51830122
55lactate metabolic process (GO:0006089)3.48955045
56positive regulation of meiotic cell cycle (GO:0051446)3.47664733
57white fat cell differentiation (GO:0050872)3.46649087
58zinc ion transmembrane transport (GO:0071577)3.42376225
59smooth muscle tissue development (GO:0048745)3.37751963
60regulation of cardiac muscle cell contraction (GO:0086004)3.34560302
61proteasome assembly (GO:0043248)3.34317681
62reproduction (GO:0000003)3.29961595
63collagen fibril organization (GO:0030199)3.26088524
64cellular zinc ion homeostasis (GO:0006882)3.25939021
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24692324
66negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.24658716
67regulation of lymphocyte chemotaxis (GO:1901623)3.23654454
68positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.23242775
69eye photoreceptor cell differentiation (GO:0001754)3.20451075
70photoreceptor cell differentiation (GO:0046530)3.20451075
71regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.17582718
72positive regulation of T cell apoptotic process (GO:0070234)3.16679879
73regulation of apoptotic process involved in morphogenesis (GO:1902337)3.16181770
74cellular response to ATP (GO:0071318)3.12579638
75positive regulation of interleukin-1 secretion (GO:0050716)3.08843256
76response to cadmium ion (GO:0046686)3.08711311
77snRNA transcription (GO:0009301)3.08514358
78regulation of thymocyte apoptotic process (GO:0070243)3.05528139
79regulation of macrophage activation (GO:0043030)3.04797571
80activation of protein kinase B activity (GO:0032148)3.04606544
81negative regulation of protein autophosphorylation (GO:0031953)3.04067040
82type B pancreatic cell development (GO:0003323)3.02957695
83female genitalia development (GO:0030540)2.98544789
84dopaminergic neuron differentiation (GO:0071542)2.95542742
85positive regulation of calcium ion import (GO:0090280)2.94014988
86endothelial cell morphogenesis (GO:0001886)2.92231215
87neuronal ion channel clustering (GO:0045161)2.89919206
88astrocyte development (GO:0014002)2.89834658
89negative regulation of calcium ion transport into cytosol (GO:0010523)2.89553671
90positive regulation of lymphocyte apoptotic process (GO:0070230)2.85749695
91glutathione derivative metabolic process (GO:1901685)2.84666416
92glutathione derivative biosynthetic process (GO:1901687)2.84666416
93regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.83566316
94regulation of gonadotropin secretion (GO:0032276)2.83494187
95positive regulation of sodium ion transmembrane transport (GO:1902307)2.77215444
96kynurenine metabolic process (GO:0070189)2.74621193
97regulation of chemokine production (GO:0032642)2.74231264
98positive regulation of cGMP metabolic process (GO:0030825)2.73235326
99regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.72413657
100negative regulation of astrocyte differentiation (GO:0048712)2.72360859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.41637440
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.67219000
3HIF1A_21447827_ChIP-Seq_MCF-7_Human3.06506518
4GATA2_21666600_ChIP-Seq_HMVEC_Human3.01258601
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73191957
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.70797084
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.55540096
8AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.51798107
9ZNF217_24962896_ChIP-Seq_MCF-7_Human2.39773987
10AHR_22903824_ChIP-Seq_MCF-7_Human2.38798065
11FOXM1_26456572_ChIP-Seq_MCF-7_Human2.11068044
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04675583
13TAF15_26573619_Chip-Seq_HEK293_Human1.99869463
14ER_23166858_ChIP-Seq_MCF-7_Human1.95252857
15CJUN_26792858_Chip-Seq_BT549_Human1.94428020
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94290844
17BCAT_22108803_ChIP-Seq_LS180_Human1.90163381
18ARNT_22903824_ChIP-Seq_MCF-7_Human1.89735145
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.84946444
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.84398043
21NR3C1_21868756_ChIP-Seq_MCF10A_Human1.83785034
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80404878
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71798113
24BRD4_25478319_ChIP-Seq_HGPS_Human1.69584287
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67284038
26GBX2_23144817_ChIP-Seq_PC3_Human1.66602038
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66515104
28PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65960052
29NANOG_19829295_ChIP-Seq_ESCs_Human1.64510740
30SOX2_19829295_ChIP-Seq_ESCs_Human1.64510740
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61743942
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.61650070
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57622844
34AR_25329375_ChIP-Seq_VCAP_Human1.57522585
35STAT3_23295773_ChIP-Seq_U87_Human1.55926773
36P300_19829295_ChIP-Seq_ESCs_Human1.55327670
37CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.54653233
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.54075214
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52396752
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51651457
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.49415700
42TCF4_23295773_ChIP-Seq_U87_Human1.48309583
43TP63_23658742_ChIP-Seq_EP156T_Human1.46380904
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43236868
45HOXB7_26014856_ChIP-Seq_BT474_Human1.42564874
46SMAD4_21799915_ChIP-Seq_A2780_Human1.40542140
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40246986
48TCF4_22108803_ChIP-Seq_LS180_Human1.38113686
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35811012
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34828592
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34730786
52CDX2_22108803_ChIP-Seq_LS180_Human1.31089425
53CBP_20019798_ChIP-Seq_JUKART_Human1.30767303
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30767303
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.30621218
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30412331
57TBL1_22424771_ChIP-Seq_293T_Human1.28056879
58RUNX2_22187159_ChIP-Seq_PCA_Human1.25783721
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24218002
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24110428
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23092979
62ETV1_20927104_ChIP-Seq_GIST48_Human1.21505657
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21498266
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.19163486
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19163486
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18979775
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17296341
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17035759
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15582617
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.15432485
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14411536
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12919303
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11077195
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10636444
75RBPJ_21746931_ChIP-Seq_IB4_Human1.10127621
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09259879
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09259879
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08921073
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08500968
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08012046
81NFYB_21822215_ChIP-Seq_K562_Human1.07592689
82FUS_26573619_Chip-Seq_HEK293_Human1.07396773
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.07142972
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06619053
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06617296
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06233953
87PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06176253
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.05756630
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05670278
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05231806
91AR_20517297_ChIP-Seq_VCAP_Human1.04960242
92CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03669898
93P53_22387025_ChIP-Seq_ESCs_Mouse1.03097947
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02880836
95MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02772375
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.02729104
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.01610209
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01443524
99NANOG_20526341_ChIP-Seq_ESCs_Human1.01163582
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.01106799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003279_aneurysm6.66651413
2MP0003011_delayed_dark_adaptation5.97801492
3MP0003950_abnormal_plasma_membrane5.61598553
4MP0002282_abnormal_trachea_morphology5.27158885
5MP0008438_abnormal_cutaneous_collagen3.99630490
6MP0001879_abnormal_lymphatic_vessel3.95020564
7MP0005645_abnormal_hypothalamus_physiol3.83145585
8MP0006054_spinal_hemorrhage3.14986662
9MP0010368_abnormal_lymphatic_system2.99350845
10MP0005646_abnormal_pituitary_gland2.89165198
11MP0005275_abnormal_skin_tensile2.69177556
12MP0001958_emphysema2.40986442
13MP0001501_abnormal_sleep_pattern2.21862781
14MP0003724_increased_susceptibility_to2.19967673
15MP0005187_abnormal_penis_morphology2.10267638
16MP0002295_abnormal_pulmonary_circulatio2.09454513
17MP0009053_abnormal_anal_canal2.04956643
18MP0003045_fibrosis1.97412725
19MP0010030_abnormal_orbit_morphology1.96478808
20MP0002009_preneoplasia1.85885474
21MP0003195_calcinosis1.78649339
22MP0005410_abnormal_fertilization1.76040708
23MP0008775_abnormal_heart_ventricle1.57894654
24MP0000767_abnormal_smooth_muscle1.54761643
25MP0003186_abnormal_redox_activity1.42849238
26MP0004147_increased_porphyrin_level1.41248915
27MP0004134_abnormal_chest_morphology1.34381749
28MP0005310_abnormal_salivary_gland1.32194966
29MP0000538_abnormal_urinary_bladder1.29020691
30MP0009697_abnormal_copulation1.27769507
31MP0004043_abnormal_pH_regulation1.25053855
32MP0000427_abnormal_hair_cycle1.22906360
33MP0003718_maternal_effect1.22554522
34MP0002160_abnormal_reproductive_system1.21705058
35MP0002254_reproductive_system_inflammat1.17277562
36MP0002168_other_aberrant_phenotype1.17178241
37MP0008995_early_reproductive_senescence1.14515812
38MP0008961_abnormal_basal_metabolism1.13439562
39MP0005395_other_phenotype1.12714559
40MP0003183_abnormal_peptide_metabolism1.09141872
41MP0005167_abnormal_blood-brain_barrier1.08077678
42MP0008057_abnormal_DNA_replication1.07576248
43MP0010307_abnormal_tumor_latency1.01907253
44MP0000343_altered_response_to1.00710198
45MP0004272_abnormal_basement_membrane1.00509486
46MP0004085_abnormal_heartbeat1.00031022
47MP0003786_premature_aging1.00012210
48MP0005389_reproductive_system_phenotype0.93830842
49MP0002876_abnormal_thyroid_physiology0.90846443
50MP0001324_abnormal_eye_pigmentation0.90501040
51MP0000613_abnormal_salivary_gland0.90489456
52MP0000372_irregular_coat_pigmentation0.89342235
53MP0004484_altered_response_of0.89100353
54MP0005551_abnormal_eye_electrophysiolog0.86853307
55MP0001177_atelectasis0.86341450
56MP0005503_abnormal_tendon_morphology0.85550615
57MP0005636_abnormal_mineral_homeostasis0.85334277
58MP0002166_altered_tumor_susceptibility0.83757740
59MP0008004_abnormal_stomach_pH0.82610510
60MP0003938_abnormal_ear_development0.82139010
61MP0002932_abnormal_joint_morphology0.81902561
62MP0005584_abnormal_enzyme/coenzyme_acti0.81565891
63MP0004924_abnormal_behavior0.81296963
64MP0005386_behavior/neurological_phenoty0.81296963
65MP0004019_abnormal_vitamin_homeostasis0.80429906
66MP0010234_abnormal_vibrissa_follicle0.77426100
67MP0001502_abnormal_circadian_rhythm0.77291054
68MP0005623_abnormal_meninges_morphology0.73980373
69MP0003656_abnormal_erythrocyte_physiolo0.73375037
70MP0003942_abnormal_urinary_system0.72007725
71MP0000377_abnormal_hair_follicle0.70036098
72MP0009763_increased_sensitivity_to0.69699629
73MP0000163_abnormal_cartilage_morphology0.69135531
74MP0002108_abnormal_muscle_morphology0.68180563
75MP0001175_abnormal_lung_morphology0.66054203
76MP0000647_abnormal_sebaceous_gland0.65933339
77MP0005023_abnormal_wound_healing0.65413146
78MP0010678_abnormal_skin_adnexa0.63280072
79MP0001666_abnormal_nutrient_absorption0.61998588
80MP0003936_abnormal_reproductive_system0.61262603
81MP0002060_abnormal_skin_morphology0.60849031
82MP0002098_abnormal_vibrissa_morphology0.58407886
83MP0000383_abnormal_hair_follicle0.57714828
84MP0001853_heart_inflammation0.56707772
85MP0000639_abnormal_adrenal_gland0.56198839
86MP0005253_abnormal_eye_physiology0.55522145
87MP0005166_decreased_susceptibility_to0.53761399
88MP0005388_respiratory_system_phenotype0.53378421
89MP0002133_abnormal_respiratory_system0.53378421
90MP0002115_abnormal_skeleton_extremities0.53202762
91MP0000249_abnormal_blood_vessel0.50128211
92MP0005164_abnormal_response_to0.49560581
93MP0002128_abnormal_blood_circulation0.49141379
94MP0004215_abnormal_myocardial_fiber0.48662894
95MP0000230_abnormal_systemic_arterial0.48000329
96MP0001873_stomach_inflammation0.47820233
97MP0002006_tumorigenesis0.45065899
98MP0001119_abnormal_female_reproductive0.43565932
99MP0001764_abnormal_homeostasis0.43423880
100MP0010329_abnormal_lipoprotein_level0.42642912

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)7.42363351
2Short middle phalanx of the 5th finger (HP:0004220)6.54770642
3Chronic sinusitis (HP:0011109)6.20604644
4Deep philtrum (HP:0002002)5.39954770
5Abnormal cartilage morphology (HP:0002763)5.31310670
6Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)5.09127508
7Pulmonary artery stenosis (HP:0004415)5.06709750
8Recurrent bronchitis (HP:0002837)4.99040125
9Increased number of teeth (HP:0011069)4.96326599
10Short hallux (HP:0010109)4.84581587
11Concave nail (HP:0001598)4.65834875
12Abnormality of the epiphyses of the hand (HP:0005924)4.58283050
13Aplasia/Hypoplasia of the hallux (HP:0008362)4.41212200
14Pheochromocytoma (HP:0002666)4.39732116
15Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.37663019
16Renal duplication (HP:0000075)4.34112853
17Mesomelia (HP:0003027)4.32859940
18Abnormality involving the epiphyses of the upper limbs (HP:0003839)4.25070840
19Flat capital femoral epiphysis (HP:0003370)3.92825119
20Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.92670588
21Abnormality of the astrocytes (HP:0100707)3.85049081
22Astrocytoma (HP:0009592)3.85049081
23Hypoplastic labia majora (HP:0000059)3.79832672
24Abnormality of the parathyroid morphology (HP:0011766)3.76205489
25Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.73228095
26Neuroendocrine neoplasm (HP:0100634)3.69639867
27Abnormality of the proximal phalanges of the hand (HP:0009834)3.61529073
28Sparse lateral eyebrow (HP:0005338)3.46388452
29Abnormality of the labia majora (HP:0012881)3.44974569
30Abnormality of the phalanges of the 5th finger (HP:0004213)3.39265650
31Bifid tongue (HP:0010297)3.33467288
32Birth length less than 3rd percentile (HP:0003561)3.32044684
33Narrow palate (HP:0000189)3.28093233
34Relative macrocephaly (HP:0004482)3.22448365
35Aqueductal stenosis (HP:0002410)3.18413374
36Decreased central vision (HP:0007663)3.17961060
37Abnormality of the nasal septum (HP:0000419)3.10932638
38Rhabdomyosarcoma (HP:0002859)3.05888694
39Bronchitis (HP:0012387)3.04429455
40Abnormality of Sharpey fibers (HP:0100685)2.98246021
41Glioma (HP:0009733)2.93998566
42Hamartoma of the eye (HP:0010568)2.92658379
43Dyschromatopsia (HP:0007641)2.90891049
44Abnormality of the right ventricle (HP:0001707)2.89158782
45Infantile muscular hypotonia (HP:0008947)2.87006965
46Small hand (HP:0200055)2.86280730
47Follicular hyperkeratosis (HP:0007502)2.77847202
48Chorioretinal atrophy (HP:0000533)2.77382478
49Chondrocalcinosis (HP:0000934)2.69388242
50Epiphyseal stippling (HP:0010655)2.69340357
51Abnormality of nail color (HP:0100643)2.66057674
52Underdeveloped nasal alae (HP:0000430)2.64276888
53Short 5th finger (HP:0009237)2.61138375
54Tracheal stenosis (HP:0002777)2.58479454
55Nasal speech (HP:0001611)2.52443372
56Abnormal delivery (HP:0001787)2.51765839
57Midline defect of the nose (HP:0004122)2.49014379
58Cholecystitis (HP:0001082)2.48494028
59Abnormal gallbladder physiology (HP:0012438)2.48494028
60Central scotoma (HP:0000603)2.45635445
61Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.45624690
62Abnormality of the femoral head (HP:0003368)2.41091270
63Neoplasm of the peripheral nervous system (HP:0100007)2.37128285
64Abnormality of macular pigmentation (HP:0008002)2.36198012
65Overgrowth (HP:0001548)2.34867791
66Meningioma (HP:0002858)2.34714280
67Hypothermia (HP:0002045)2.32437519
68Cone-rod dystrophy (HP:0000548)2.29351146
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23863508
70Abnormality of the epiphysis of the femoral head (HP:0010574)2.18946913
71Abnormality of the middle phalanges of the hand (HP:0009833)2.11483641
72Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.11279981
73Abnormality of femoral epiphyses (HP:0006499)2.11279981
74Labial hypoplasia (HP:0000066)2.10741879
75Macroorchidism (HP:0000053)2.10257860
76Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08840536
77Short middle phalanx of finger (HP:0005819)2.07363179
78Metaphyseal dysplasia (HP:0100255)2.06186496
79Midface retrusion (HP:0011800)2.02660595
80Absent toe (HP:0010760)1.99115300
81Thin upper lip vermilion (HP:0000219)1.97049624
82Short thumb (HP:0009778)1.95483580
83Irregular epiphyses (HP:0010582)1.94044795
84Long palpebral fissure (HP:0000637)1.89134148
85Increased serum pyruvate (HP:0003542)1.88346319
86Absent epiphyses (HP:0010577)1.86493478
87Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86493478
88Pectus carinatum (HP:0000768)1.86044994
89Blue sclerae (HP:0000592)1.84858035
90Hypophosphatemic rickets (HP:0004912)1.84843265
91Hypoplastic female external genitalia (HP:0012815)1.84131613
92Recurrent corneal erosions (HP:0000495)1.82258494
93Abnormality of glycolysis (HP:0004366)1.79647050
94Neoplasm of striated muscle (HP:0009728)1.78310408
95Tubulointerstitial nephritis (HP:0001970)1.77199543
96Exotropia (HP:0000577)1.71731622
97Abnormal epiphyseal ossification (HP:0010656)1.68000834
98Short distal phalanx of finger (HP:0009882)1.67771815
99Hypoplastic ischia (HP:0003175)1.66868548
100Vascular tortuosity (HP:0004948)1.62962366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK249.20581432
2MAP4K25.41022159
3MST44.41023692
4PIK3CG4.02483088
5FRK3.77240383
6STK393.28544111
7ILK2.75403354
8TGFBR22.22904819
9OXSR12.06522205
10INSRR1.95230048
11NUAK11.68064097
12BUB11.58276840
13FER1.57959666
14EIF2AK31.48678686
15EIF2AK11.48008033
16BRSK21.46447457
17DDR21.46041594
18MKNK21.38579240
19GRK11.38324753
20NEK11.34274328
21PTK2B1.23979260
22TAF11.22528055
23PLK21.19267904
24PLK41.15915546
25PRKCQ1.08976393
26GRK51.06950941
27IRAK31.04923078
28BRSK11.03678951
29DYRK30.95933345
30AKT30.95912205
31STK100.94631931
32PTK20.93496584
33MET0.91685467
34LATS10.87700580
35ADRBK20.87395527
36WEE10.83584971
37ACVR1B0.81527206
38FGFR10.80842057
39BMPR1B0.78782906
40TEC0.77950238
41BCR0.76727812
42PRKCI0.74152390
43TAOK30.69271125
44MAP3K30.68731640
45TRPM70.65338658
46MAPKAPK50.64932102
47STK30.63326829
48VRK20.62699005
49PAK30.62172092
50FLT30.61443017
51ARAF0.61388087
52ADRBK10.59482545
53MKNK10.54755532
54MAPKAPK30.53614298
55LRRK20.50083292
56TNK20.49184310
57PRKCE0.47229389
58JAK10.46669642
59FGR0.46035798
60LATS20.43038398
61TESK10.42634226
62FGFR20.42563831
63TSSK60.40746136
64TRIM280.38990029
65PDGFRB0.38338963
66ERBB30.37857848
67SGK30.37429696
68BCKDK0.35882584
69MATK0.34813254
70CAMK10.32158555
71WNK40.28835300
72BMPR20.28345247
73IKBKB0.27603525
74MELK0.26336910
75CAMKK20.26301010
76PRKAA20.26032544
77MAP3K40.25636648
78AKT20.25570387
79STK160.24442890
80CSNK1D0.24378134
81PLK30.22826035
82CDK30.22074742
83BMX0.21702321
84EGFR0.21460296
85ROCK10.19587184
86VRK10.19095385
87ABL20.18409974
88CAMK2D0.17859634
89ITK0.17208447
90PNCK0.16961975
91PIK3CA0.16803833
92ABL10.16779672
93CSNK1A1L0.15738185
94CSNK1E0.15004551
95PRKCG0.14936943
96CDK80.14431060
97CAMK1G0.14213844
98NTRK30.12060264
99RPS6KB20.10981318
100CSNK1G10.10838388

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049785.65011864
2Fatty acid biosynthesis_Homo sapiens_hsa000614.21403665
3Circadian rhythm_Homo sapiens_hsa047103.19168766
4Proteasome_Homo sapiens_hsa030503.16764956
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.03806404
6Protein export_Homo sapiens_hsa030603.01557270
7Nitrogen metabolism_Homo sapiens_hsa009102.80964663
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.63293838
9Glutathione metabolism_Homo sapiens_hsa004802.10129763
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.95041014
11Malaria_Homo sapiens_hsa051441.82207074
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.80658438
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79716275
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69474977
15Complement and coagulation cascades_Homo sapiens_hsa046101.62150783
16Hedgehog signaling pathway_Homo sapiens_hsa043401.54524642
17Chemical carcinogenesis_Homo sapiens_hsa052041.47564199
18Phototransduction_Homo sapiens_hsa047441.46720914
19Fatty acid metabolism_Homo sapiens_hsa012121.44031048
20Sulfur metabolism_Homo sapiens_hsa009201.41387362
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41029920
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38480868
23Butanoate metabolism_Homo sapiens_hsa006501.33737631
24Starch and sucrose metabolism_Homo sapiens_hsa005001.31662544
25HIF-1 signaling pathway_Homo sapiens_hsa040661.29204835
26Sphingolipid metabolism_Homo sapiens_hsa006001.29029379
27Linoleic acid metabolism_Homo sapiens_hsa005911.24353712
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23683010
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22611210
30Regulation of autophagy_Homo sapiens_hsa041401.21823553
31ECM-receptor interaction_Homo sapiens_hsa045121.19886491
32Arginine and proline metabolism_Homo sapiens_hsa003301.17982905
33Tryptophan metabolism_Homo sapiens_hsa003801.16607809
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10545801
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.10433051
36RNA polymerase_Homo sapiens_hsa030201.05970638
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04817389
38Fatty acid degradation_Homo sapiens_hsa000711.03829324
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02654084
40Selenocompound metabolism_Homo sapiens_hsa004501.01732578
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01517783
42Peroxisome_Homo sapiens_hsa041460.98653791
43Ether lipid metabolism_Homo sapiens_hsa005650.98285609
44Tyrosine metabolism_Homo sapiens_hsa003500.96006773
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94491661
46PPAR signaling pathway_Homo sapiens_hsa033200.94483851
47One carbon pool by folate_Homo sapiens_hsa006700.93278314
48Propanoate metabolism_Homo sapiens_hsa006400.90818210
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90363289
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88329867
51Proteoglycans in cancer_Homo sapiens_hsa052050.88220228
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.87646145
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83755939
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83011301
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81307012
56Legionellosis_Homo sapiens_hsa051340.80362037
57Arachidonic acid metabolism_Homo sapiens_hsa005900.80346073
58RNA degradation_Homo sapiens_hsa030180.75001712
59Retinol metabolism_Homo sapiens_hsa008300.74743967
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70170977
61Fanconi anemia pathway_Homo sapiens_hsa034600.67803278
62Olfactory transduction_Homo sapiens_hsa047400.61391578
63TGF-beta signaling pathway_Homo sapiens_hsa043500.58619223
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57207099
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55697753
66Galactose metabolism_Homo sapiens_hsa000520.53855120
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53726191
68African trypanosomiasis_Homo sapiens_hsa051430.50723597
69Glycerolipid metabolism_Homo sapiens_hsa005610.49088979
70Purine metabolism_Homo sapiens_hsa002300.48777615
71Basal transcription factors_Homo sapiens_hsa030220.48538412
72Serotonergic synapse_Homo sapiens_hsa047260.48517177
73Hippo signaling pathway_Homo sapiens_hsa043900.47202026
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44031266
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41369245
76ABC transporters_Homo sapiens_hsa020100.40707430
77Basal cell carcinoma_Homo sapiens_hsa052170.39420035
78Metabolic pathways_Homo sapiens_hsa011000.37458894
79Measles_Homo sapiens_hsa051620.37438919
80Protein digestion and absorption_Homo sapiens_hsa049740.36821135
81Hematopoietic cell lineage_Homo sapiens_hsa046400.36284290
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34766366
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34278028
84Ovarian steroidogenesis_Homo sapiens_hsa049130.33123514
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32972015
86Dilated cardiomyopathy_Homo sapiens_hsa054140.31972362
87Adherens junction_Homo sapiens_hsa045200.31838035
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.30466757
89p53 signaling pathway_Homo sapiens_hsa041150.29712607
90Ras signaling pathway_Homo sapiens_hsa040140.28930364
91N-Glycan biosynthesis_Homo sapiens_hsa005100.28753133
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28601781
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28361289
94Salivary secretion_Homo sapiens_hsa049700.28151767
95Phenylalanine metabolism_Homo sapiens_hsa003600.27916348
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27626992
97Focal adhesion_Homo sapiens_hsa045100.27230128
98Pancreatic secretion_Homo sapiens_hsa049720.26522593
99Nicotine addiction_Homo sapiens_hsa050330.25489562
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24570089

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