VMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemosensory behavior (GO:0007635)9.66369618
2protein localization to cilium (GO:0061512)6.31790454
3axonemal dynein complex assembly (GO:0070286)6.27587224
4ethanol oxidation (GO:0006069)5.47778930
5cellular glucuronidation (GO:0052695)5.45584998
6uronic acid metabolic process (GO:0006063)5.43269298
7glucuronate metabolic process (GO:0019585)5.43269298
8regulation of cholesterol biosynthetic process (GO:0045540)5.26125411
9negative regulation of interleukin-12 production (GO:0032695)5.20728487
10regulation of mononuclear cell migration (GO:0071675)5.04796147
11positive regulation of digestive system process (GO:0060456)4.67719170
12epoxygenase P450 pathway (GO:0019373)4.66357412
13one-carbon compound transport (GO:0019755)4.62945632
14motile cilium assembly (GO:0044458)4.51246587
15tachykinin receptor signaling pathway (GO:0007217)4.43745064
16response to peptidoglycan (GO:0032494)4.41611849
17cellular response to thyroid hormone stimulus (GO:0097067)4.38493244
18negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.37792312
19neutrophil activation involved in immune response (GO:0002283)4.34779853
20glycosphingolipid catabolic process (GO:0046479)4.32795907
21alkaloid metabolic process (GO:0009820)4.29508521
22immunoglobulin mediated immune response (GO:0016064)4.28544024
23cilium or flagellum-dependent cell motility (GO:0001539)4.28054317
24exogenous drug catabolic process (GO:0042738)4.16351853
25ethanol metabolic process (GO:0006067)4.15956336
26sulfur amino acid catabolic process (GO:0000098)4.06449785
27flavonoid metabolic process (GO:0009812)4.05066532
28macrophage activation involved in immune response (GO:0002281)3.94549237
29glycolipid catabolic process (GO:0019377)3.86611943
30water-soluble vitamin biosynthetic process (GO:0042364)3.84864472
31amino sugar catabolic process (GO:0046348)3.83493403
32N-acetylneuraminate metabolic process (GO:0006054)3.82521419
33oligosaccharide catabolic process (GO:0009313)3.81633019
34T-helper 1 type immune response (GO:0042088)3.77826493
35drug catabolic process (GO:0042737)3.72898711
36regulation of cholesterol metabolic process (GO:0090181)3.70541067
37antibacterial humoral response (GO:0019731)3.70054605
38cilium movement (GO:0003341)3.64059250
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.62077887
40hormone catabolic process (GO:0042447)3.61720675
41negative regulation of lipase activity (GO:0060192)3.58007166
42regulation of macrophage chemotaxis (GO:0010758)3.57744113
43renal absorption (GO:0070293)3.50945854
44myeloid dendritic cell differentiation (GO:0043011)3.50811524
45positive regulation of chemokine biosynthetic process (GO:0045080)3.49291112
46regulation of cytokine secretion involved in immune response (GO:0002739)3.45476657
47regulation of podosome assembly (GO:0071801)3.44543682
48regulation of tolerance induction (GO:0002643)3.44119305
49antimicrobial humoral response (GO:0019730)3.42538661
50ceramide catabolic process (GO:0046514)3.40717405
51NIK/NF-kappaB signaling (GO:0038061)3.37660500
52negative regulation of nitric oxide biosynthetic process (GO:0045019)3.37344155
53response to thyroid hormone (GO:0097066)3.31306194
54interferon-gamma-mediated signaling pathway (GO:0060333)3.30162632
55regulation of vitamin D biosynthetic process (GO:0060556)3.28173291
56regulation of sodium ion transmembrane transport (GO:1902305)3.27368420
57regulation of secondary heart field cardioblast proliferation (GO:0003266)3.25963880
58regulation of cardioblast proliferation (GO:0003264)3.25963880
59response to xenobiotic stimulus (GO:0009410)3.25520033
60membrane lipid catabolic process (GO:0046466)3.25000104
61regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.19621369
62omega-hydroxylase P450 pathway (GO:0097267)3.18811812
63reactive oxygen species biosynthetic process (GO:1903409)3.17996847
64adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.15984352
65sphingolipid catabolic process (GO:0030149)3.15636290
66negative regulation of cytokine production involved in immune response (GO:0002719)3.15388168
67L-phenylalanine catabolic process (GO:0006559)3.14538598
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.14538598
69regulation of cholesterol storage (GO:0010885)3.13659274
70regulation of chemokine biosynthetic process (GO:0045073)3.13587532
71epithelial cilium movement (GO:0003351)3.13530821
72positive regulation of hormone biosynthetic process (GO:0046886)3.13296023
73gas transport (GO:0015669)3.11251761
74activation of protein kinase A activity (GO:0034199)3.11116478
75monocyte chemotaxis (GO:0002548)3.11020857
76positive regulation of tolerance induction (GO:0002645)3.09939610
77positive regulation of heat generation (GO:0031652)3.08122611
78positive regulation of antigen processing and presentation (GO:0002579)3.06289035
79barbed-end actin filament capping (GO:0051016)3.03842715
80myeloid dendritic cell activation (GO:0001773)3.02929226
81positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.02253978
82protein insertion into membrane (GO:0051205)3.02198627
83negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.99317911
84regulation of mast cell degranulation (GO:0043304)2.99073364
85regulation of antigen processing and presentation (GO:0002577)2.98908235
86bile acid biosynthetic process (GO:0006699)2.98391708
87positive regulation of monocyte chemotaxis (GO:0090026)2.98023508
88detection of molecule of bacterial origin (GO:0032490)2.97660579
89L-phenylalanine metabolic process (GO:0006558)2.97571521
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97571521
91B cell mediated immunity (GO:0019724)2.97178099
92tolerance induction (GO:0002507)2.96609784
93negative regulation of cell killing (GO:0031342)2.94612175
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.94612175
95granulocyte activation (GO:0036230)2.92782435
96virion attachment to host cell (GO:0019062)2.92163102
97adhesion of symbiont to host cell (GO:0044650)2.92163102
98negative regulation of myeloid cell apoptotic process (GO:0033033)2.91894368
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90775934
100regulation of membrane protein ectodomain proteolysis (GO:0051043)2.88477899
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87860065
102macrophage activation (GO:0042116)2.87750326
103positive regulation of gamma-delta T cell activation (GO:0046645)2.86896405
104positive regulation by symbiont of host defense response (GO:0052509)2.85980617
105modulation by symbiont of host defense response (GO:0052031)2.85980617
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85980617
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85980617
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.85980617
109modulation by symbiont of host immune response (GO:0052553)2.85980617
110high-density lipoprotein particle remodeling (GO:0034375)2.84863145
111positive regulation of type 2 immune response (GO:0002830)2.84532030
112xenobiotic catabolic process (GO:0042178)2.84353714
113dendritic cell differentiation (GO:0097028)2.82810746
114regulation of inflammatory response to antigenic stimulus (GO:0002861)2.82614758
115cysteine metabolic process (GO:0006534)2.81096302
116phenylpropanoid metabolic process (GO:0009698)2.79964475
117response to protozoan (GO:0001562)2.77690115
118regulation of sodium ion transmembrane transporter activity (GO:2000649)2.77625779
119germinal center formation (GO:0002467)2.77119808
120eosinophil chemotaxis (GO:0048245)2.77040661
121cellular response to arsenic-containing substance (GO:0071243)2.76911053
122positive regulation of leukocyte degranulation (GO:0043302)2.76274631
123negative regulation of astrocyte differentiation (GO:0048712)2.75984292
124positive regulation of mast cell degranulation (GO:0043306)2.75823721
125positive regulation of mast cell activation involved in immune response (GO:0033008)2.75823721
126primary alcohol catabolic process (GO:0034310)2.74851827
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74438391
128regulation of sodium ion transport (GO:0002028)2.74203193
129positive regulation of steroid metabolic process (GO:0045940)2.73502546
130regulation of T-helper 2 cell differentiation (GO:0045628)2.73212411
131regulation of germinal center formation (GO:0002634)2.71969426
132amino-acid betaine metabolic process (GO:0006577)2.70907593
133L-ascorbic acid metabolic process (GO:0019852)2.70393309
134cellular response to interferon-gamma (GO:0071346)2.69728467
135regulation of mast cell activation involved in immune response (GO:0033006)2.69337776
136positive regulation of cellular amide metabolic process (GO:0034250)2.69252542
137lung epithelium development (GO:0060428)2.68485459
138apoptotic cell clearance (GO:0043277)2.68367537
139regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68152587
140regulation of superoxide anion generation (GO:0032928)2.67982041
141carnitine metabolic process (GO:0009437)2.66901663
142defense response to protozoan (GO:0042832)2.66828634
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.66236853
144cellular response to lipopolysaccharide (GO:0071222)2.65991742
145detection of other organism (GO:0098543)2.65427969
146cellular copper ion homeostasis (GO:0006878)2.65409522
147relaxation of cardiac muscle (GO:0055119)2.65103786
148positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.64241290
149short-chain fatty acid metabolic process (GO:0046459)2.63527143
150cellular response to type I interferon (GO:0071357)2.63108314
151type I interferon signaling pathway (GO:0060337)2.63108314
152branching involved in labyrinthine layer morphogenesis (GO:0060670)2.63052080
153detection of external biotic stimulus (GO:0098581)2.62688990
154left/right pattern formation (GO:0060972)2.62421770
155regulation of steroid hormone biosynthetic process (GO:0090030)2.62216880
156triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.61785269
157mating behavior (GO:0007617)2.59513154
158auditory receptor cell differentiation (GO:0042491)2.58486980
159imidazole-containing compound metabolic process (GO:0052803)2.57129052
160positive regulation of hormone metabolic process (GO:0032352)2.56832741
161peptidyl-glutamic acid carboxylation (GO:0017187)2.56364524
162protein carboxylation (GO:0018214)2.56364524
163positive regulation of steroid biosynthetic process (GO:0010893)2.55318290
164reverse cholesterol transport (GO:0043691)2.54275470
165urea cycle (GO:0000050)2.51866511
166urea metabolic process (GO:0019627)2.51866511
167aromatic amino acid family catabolic process (GO:0009074)2.51694881
168positive regulation of macrophage cytokine production (GO:0060907)2.51148584
169vitamin biosynthetic process (GO:0009110)2.50895995
170lateral ventricle development (GO:0021670)2.48207738
171toxin metabolic process (GO:0009404)2.47941288
172regulation of heart rate by cardiac conduction (GO:0086091)2.47676348
173regulation of fibrinolysis (GO:0051917)2.46041112
174alpha-linolenic acid metabolic process (GO:0036109)2.45609615
175peptide biosynthetic process (GO:0043043)2.43502016
176cAMP biosynthetic process (GO:0006171)2.41703679
177regulation of lipoprotein metabolic process (GO:0050746)2.40647926
178negative regulation of sodium ion transport (GO:0010766)2.38043823
179response to nitrosative stress (GO:0051409)2.36126863
180glyoxylate metabolic process (GO:0046487)2.35910618
181camera-type eye morphogenesis (GO:0048593)2.33608773
182water transport (GO:0006833)2.31650944
183cellular modified amino acid catabolic process (GO:0042219)2.31424494
184cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.27607432
185aldehyde catabolic process (GO:0046185)2.26821533
186ovulation cycle (GO:0042698)2.25831212
187nitrogen cycle metabolic process (GO:0071941)2.24527325
188fatty acid oxidation (GO:0019395)2.24095820
189benzene-containing compound metabolic process (GO:0042537)2.23900664
190negative regulation of fibrinolysis (GO:0051918)2.23739576
191bile acid metabolic process (GO:0008206)2.23584097
192diterpenoid biosynthetic process (GO:0016102)2.22124551
193hydrogen peroxide biosynthetic process (GO:0050665)2.22066293
194lipid oxidation (GO:0034440)2.21055796
195positive regulation of fatty acid beta-oxidation (GO:0032000)2.20158365
196negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.18937796
197membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.18771116
198sensory perception of smell (GO:0007608)18.7979756
199sensory perception of chemical stimulus (GO:0007606)10.1571650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.50109254
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.28339723
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.91667189
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.83137418
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.83080127
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.38122479
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.34465729
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.20006984
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99536086
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98497800
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.97310558
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86849470
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.85485383
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70059210
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.49296879
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44736677
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42510708
18DROSHA_22980978_ChIP-Seq_HELA_Human2.40069009
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33603372
20ERG_21242973_ChIP-ChIP_JURKAT_Human2.20801258
21VDR_24763502_ChIP-Seq_THP-1_Human2.13968330
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13573709
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11332602
24VDR_21846776_ChIP-Seq_THP-1_Human2.02327221
25SPI1_23127762_ChIP-Seq_K562_Human1.99291151
26CLOCK_20551151_ChIP-Seq_293T_Human1.96285298
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96236873
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.88094763
29VDR_24787735_ChIP-Seq_THP-1_Human1.82553220
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80646670
31ZNF263_19887448_ChIP-Seq_K562_Human1.80500216
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79831642
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.79521148
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78659519
35STAT1_20625510_ChIP-Seq_HELA_Human1.77570733
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76485268
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74266867
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68344150
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67563594
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67181706
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66662196
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66662196
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66078449
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64072597
45SPI1_23547873_ChIP-Seq_NB4_Human1.63937793
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60513742
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60460176
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59447567
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56678935
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.55485419
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.55352575
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54165742
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.53977210
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.51147131
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.51092209
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49222423
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46137612
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44488636
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43563378
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42315965
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41066561
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39452140
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38570386
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37771406
65MAF_26560356_Chip-Seq_TH1_Human1.34818784
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.34087911
67AHR_22903824_ChIP-Seq_MCF-7_Human1.32721005
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32352611
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32108780
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31939613
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31205398
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30394460
73BCL6_27268052_Chip-Seq_Bcells_Human1.30350675
74BCOR_27268052_Chip-Seq_Bcells_Human1.29357133
75GATA1_19941826_ChIP-Seq_K562_Human1.29175794
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28340237
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28328669
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27104997
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26802149
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26325161
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25224171
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.24570948
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.24189407
84KDM2B_26808549_Chip-Seq_K562_Human1.24178753
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.23875343
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23570314
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23569825
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23484327
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23379755
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23041629
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22928097
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22787121
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21799794
94TAF15_26573619_Chip-Seq_HEK293_Human1.21751414
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21199427
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.19434278
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18374343
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18005458
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17698256
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15480937
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14151178
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.12192609
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11718384
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.11364776
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10797696
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09924333
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.09832974
108GATA3_24758297_ChIP-Seq_MCF-7_Human1.09420301
109SMC4_20622854_ChIP-Seq_HELA_Human1.09055917
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.08787038
111SCL_19346495_ChIP-Seq_HPC-7_Human1.07224303
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05850251
113KDM2B_26808549_Chip-Seq_DND41_Human1.04813938
114TCF7_22412390_ChIP-Seq_EML_Mouse1.03676125
115ERG_20517297_ChIP-Seq_VCAP_Human1.03191761
116TFEB_21752829_ChIP-Seq_HELA_Human1.03146422
117SA1_27219007_Chip-Seq_Bcells_Human1.02984292
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02552662
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02408334
120SA1_27219007_Chip-Seq_ERYTHROID_Human1.02016813
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01667286
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01657550
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01056274
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.00940904
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00309796
126* P68_20966046_ChIP-Seq_HELA_Human0.99866477
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99755037
128MAF_26560356_Chip-Seq_TH2_Human0.99095663
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.98576184
130PU_27001747_Chip-Seq_BMDM_Mouse0.98507487
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98419414
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98041608
133LXR_22292898_ChIP-Seq_THP-1_Human0.97332475
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97185877
135UTX_26944678_Chip-Seq_JUKART_Human0.96662670
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96605190
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.96189905
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.94205339
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94191822
140RACK7_27058665_Chip-Seq_MCF-7_Human0.94106973
141EZH2_27294783_Chip-Seq_ESCs_Mouse0.93647988
142FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93631449
143PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92953614
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89913274
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89893019
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.89825869
147CTCF_27219007_Chip-Seq_Bcells_Human0.89195180
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89193453
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.89017132
150SOX2_20726797_ChIP-Seq_SW620_Human0.88926383
151NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88859646
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88859646
153TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88812394
154ISL1_27105846_Chip-Seq_CPCs_Mouse0.88805213
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88267497
156CTCF_20526341_ChIP-Seq_ESCs_Human0.88191295
157EZH2_22144423_ChIP-Seq_EOC_Human0.87925448
158P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87728331
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87525253
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87336798
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.87294243
162GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86510232
163TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85852251
164WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83433982
165CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83369436
166FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82469254
167TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82339487
168LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81609849
169CDX2_20551321_ChIP-Seq_CACO-2_Human0.80510065
170PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.79568629
171TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79434466
172KLF5_25053715_ChIP-Seq_YYC3_Human0.79073342
173ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78483793
174FOXA1_25552417_ChIP-Seq_VCAP_Human0.78241297
175SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77060071
176ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76967038
177RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76823333
178MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76172870
179AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75589060
180PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75512809
181GATA4_25053715_ChIP-Seq_YYC3_Human0.75494269
182GATA1_22025678_ChIP-Seq_K562_Human0.75395641
183CBP_21632823_ChIP-Seq_H3396_Human0.75143364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.81411116
2MP0005499_abnormal_olfactory_system5.75858056
3MP0005394_taste/olfaction_phenotype5.75858056
4MP0008789_abnormal_olfactory_epithelium4.96334839
5MP0003303_peritoneal_inflammation4.37173663
6MP0002148_abnormal_hypersensitivity_rea3.37415373
7MP0002139_abnormal_hepatobiliary_system2.93308567
8MP0003436_decreased_susceptibility_to2.88782105
9MP0001835_abnormal_antigen_presentation2.81757499
10MP0009785_altered_susceptibility_to2.75154805
11MP0003806_abnormal_nucleotide_metabolis2.68272387
12MP0003172_abnormal_lysosome_physiology2.67204307
13MP0005365_abnormal_bile_salt2.61890148
14MP0004510_myositis2.57806915
15MP0001790_abnormal_immune_system2.55582046
16MP0005387_immune_system_phenotype2.55582046
17MP0003879_abnormal_hair_cell2.54202054
18MP0002419_abnormal_innate_immunity2.53353038
19MP0003724_increased_susceptibility_to2.44234082
20MP0005025_abnormal_response_to2.40662050
21MP0000343_altered_response_to2.32326643
22MP0003191_abnormal_cellular_cholesterol2.30123477
23MP0005671_abnormal_response_to2.29076075
24MP0005000_abnormal_immune_tolerance2.23238541
25MP0001346_abnormal_lacrimal_gland2.05671020
26MP0005360_urolithiasis2.02505495
27MP0001984_abnormal_olfaction11.6543388
28MP0003300_gastrointestinal_ulcer1.96733604
29MP0002254_reproductive_system_inflammat1.96500579
30MP0002452_abnormal_antigen_presenting1.95103252
31MP0010030_abnormal_orbit_morphology1.92282290
32MP0000685_abnormal_immune_system1.90632006
33MP0001533_abnormal_skeleton_physiology1.88765430
34MP0005085_abnormal_gallbladder_physiolo1.85054799
35MP0002723_abnormal_immune_serum1.82644149
36MP0006054_spinal_hemorrhage1.81562146
37MP0005167_abnormal_blood-brain_barrier1.77359713
38MP0001485_abnormal_pinna_reflex1.74095510
39MP0010155_abnormal_intestine_physiology1.72970027
40MP0001845_abnormal_inflammatory_respons1.68575997
41MP0001853_heart_inflammation1.67553980
42MP0002998_abnormal_bone_remodeling1.67098982
43MP0009278_abnormal_bone_marrow1.67009696
44MP0001800_abnormal_humoral_immune1.65636826
45MP0003453_abnormal_keratinocyte_physiol1.65455364
46MP0002233_abnormal_nose_morphology1.64005872
47MP0008004_abnormal_stomach_pH1.63678801
48MP0008469_abnormal_protein_level1.61135752
49MP0010329_abnormal_lipoprotein_level1.59246397
50MP0002405_respiratory_system_inflammati1.55085883
51MP0000858_altered_metastatic_potential1.52759968
52MP0001819_abnormal_immune_cell1.49969490
53MP0003448_altered_tumor_morphology1.49250534
54MP0002420_abnormal_adaptive_immunity1.48890823
55MP0010234_abnormal_vibrissa_follicle1.45705957
56MP0005464_abnormal_platelet_physiology1.41381507
57MP0005166_decreased_susceptibility_to1.38066648
58MP0005451_abnormal_body_composition1.37836849
59MP0004947_skin_inflammation1.36103005
60MP0005397_hematopoietic_system_phenotyp1.33652193
61MP0001545_abnormal_hematopoietic_system1.33652193
62MP0005248_abnormal_Harderian_gland1.29331779
63MP0009333_abnormal_splenocyte_physiolog1.23563882
64MP0005165_increased_susceptibility_to1.20990285
65MP0003656_abnormal_erythrocyte_physiolo1.18148912
66MP0008260_abnormal_autophagy1.15730638
67MP0003252_abnormal_bile_duct1.12152733
68MP0004885_abnormal_endolymph1.12046239
69MP0005645_abnormal_hypothalamus_physiol1.09223511
70MP0001963_abnormal_hearing_physiology1.08829244
71MP0003195_calcinosis1.05988556
72MP0005377_hearing/vestibular/ear_phenot1.02975165
73MP0003878_abnormal_ear_physiology1.02975165
74MP0002876_abnormal_thyroid_physiology1.00629560
75MP0001663_abnormal_digestive_system1.00601463
76MP0003705_abnormal_hypodermis_morpholog0.98893913
77MP0000534_abnormal_ureter_morphology0.98827518
78MP0002138_abnormal_hepatobiliary_system0.98579217
79MP0000613_abnormal_salivary_gland0.98296097
80MP0005164_abnormal_response_to0.97255570
81MP0002822_catalepsy0.96515388
82MP0003075_altered_response_to0.96503779
83MP0000604_amyloidosis0.96494941
84MP0000716_abnormal_immune_system0.95389860
85MP0005584_abnormal_enzyme/coenzyme_acti0.95208190
86MP0002332_abnormal_exercise_endurance0.93736333
87MP0003329_amyloid_beta_deposits0.93192708
88MP0009763_increased_sensitivity_to0.92729879
89MP0000026_abnormal_inner_ear0.92247774
90MP0003828_pulmonary_edema0.90715801
91MP0000920_abnormal_myelination0.90522120
92MP0004134_abnormal_chest_morphology0.89035484
93MP0002877_abnormal_melanocyte_morpholog0.88828333
94MP0003942_abnormal_urinary_system0.88397317
95MP0009780_abnormal_chondrocyte_physiolo0.86586707
96MP0002909_abnormal_adrenal_gland0.83509701
97MP0002837_dystrophic_cardiac_calcinosis0.81967800
98MP0009840_abnormal_foam_cell0.80504257
99MP0004883_abnormal_blood_vessel0.80237087
100MP0010386_abnormal_urinary_bladder0.79900709
101MP0003634_abnormal_glial_cell0.79461484
102MP0000609_abnormal_liver_physiology0.77060280
103MP0002132_abnormal_respiratory_system0.76557835
104MP0005390_skeleton_phenotype0.76425454
105MP0002653_abnormal_ependyma_morphology0.75290818
106MP0002118_abnormal_lipid_homeostasis0.73135598
107MP0003795_abnormal_bone_structure0.72566969
108MP0002184_abnormal_innervation0.72297120
109MP0009384_cardiac_valve_regurgitation0.71584861
110MP0009765_abnormal_xenobiotic_induced0.71315739
111MP0002090_abnormal_vision0.69586762
112MP0003186_abnormal_redox_activity0.69327286
113MP0002429_abnormal_blood_cell0.69267199
114MP0001666_abnormal_nutrient_absorption0.68981142
115MP0000516_abnormal_urinary_system0.68390240
116MP0005367_renal/urinary_system_phenotyp0.68390240
117MP0010307_abnormal_tumor_latency0.67445447
118MP0000689_abnormal_spleen_morphology0.66683753
119MP0000249_abnormal_blood_vessel0.65620675
120MP0005623_abnormal_meninges_morphology0.64026345
121MP0009053_abnormal_anal_canal0.63455355
122MP0006082_CNS_inflammation0.63084699
123MP0005381_digestive/alimentary_phenotyp0.63014199
124MP0005647_abnormal_sex_gland0.62458376
125MP0009643_abnormal_urine_homeostasis0.61795599
126MP0005266_abnormal_metabolism0.61101284
127MP0004019_abnormal_vitamin_homeostasis0.60983626
128MP0005332_abnormal_amino_acid0.60511216
129MP0002398_abnormal_bone_marrow0.60104593
130MP0003183_abnormal_peptide_metabolism0.59995357
131MP0004858_abnormal_nervous_system0.59887869
132MP0001849_ear_inflammation0.59249460
133MP0002896_abnormal_bone_mineralization0.58019021
134MP0005319_abnormal_enzyme/_coenzyme0.57792480
135MP0002277_abnormal_respiratory_mucosa0.56663515
136MP0000762_abnormal_tongue_morphology0.56534554
137MP0005275_abnormal_skin_tensile0.56297127
138MP0005310_abnormal_salivary_gland0.55207743
139MP0003690_abnormal_glial_cell0.54490893
140MP0001348_abnormal_lacrimal_gland0.53478469
141MP0001299_abnormal_eye_distance/0.53438992
142MP0003566_abnormal_cell_adhesion0.53283065
143MP0005408_hypopigmentation0.52576770
144MP0002752_abnormal_somatic_nervous0.52417292
145MP0000049_abnormal_middle_ear0.51032391
146MP0008874_decreased_physiological_sensi0.50344231
147MP0010678_abnormal_skin_adnexa0.48798982
148MP0002249_abnormal_larynx_morphology0.47977447
149MP0008438_abnormal_cutaneous_collagen0.47492993
150MP0009764_decreased_sensitivity_to0.47392450
151MP0002295_abnormal_pulmonary_circulatio0.47388040
152MP0002272_abnormal_nervous_system0.45914872
153MP0000579_abnormal_nail_morphology0.42504258
154MP0002282_abnormal_trachea_morphology0.42384310
155MP0005376_homeostasis/metabolism_phenot0.40829524
156MP0005508_abnormal_skeleton_morphology0.40611957
157MP0005187_abnormal_penis_morphology0.39870592
158MP0000465_gastrointestinal_hemorrhage0.38450164
159MP0004782_abnormal_surfactant_physiolog0.36923882
160MP0002882_abnormal_neuron_morphology0.36456007
161MP0005083_abnormal_biliary_tract0.36103684
162MP0002098_abnormal_vibrissa_morphology0.35077037
163MP0004742_abnormal_vestibular_system0.35074843
164MP0000163_abnormal_cartilage_morphology0.35015531
165MP0005058_abnormal_lysosome_morphology0.34477706
166MP0003938_abnormal_ear_development0.34195922
167MP0001542_abnormal_bone_strength0.33688221
168MP0003633_abnormal_nervous_system0.33155407
169MP0005503_abnormal_tendon_morphology0.32399041
170MP0002796_impaired_skin_barrier0.32229406
171MP0004043_abnormal_pH_regulation0.32091512
172MP0008872_abnormal_physiological_respon0.30793518

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.85843029
2Abnormality of liposaccharide metabolism (HP:0010968)6.85843029
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.85843029
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.93929230
5Abnormal respiratory motile cilium morphology (HP:0005938)5.44446501
6Abnormal respiratory epithelium morphology (HP:0012253)5.44446501
7Absent/shortened dynein arms (HP:0200106)5.37192319
8Dynein arm defect of respiratory motile cilia (HP:0012255)5.37192319
9Abnormal respiratory motile cilium physiology (HP:0012261)5.19244300
10Abnormal ciliary motility (HP:0012262)5.00430280
11Disinhibition (HP:0000734)4.87485901
12Rhinitis (HP:0012384)4.81397514
13Epiphyseal dysplasia (HP:0002656)4.80942229
14Abnormality of the nasal mucosa (HP:0000433)4.68373406
15Increased cerebral lipofuscin (HP:0011813)4.65491077
16Nasal polyposis (HP:0100582)4.59051226
17Vacuolated lymphocytes (HP:0001922)4.47988151
18Dysostosis multiplex (HP:0000943)4.31847813
19Atrioventricular block (HP:0001678)4.18512491
20Deep venous thrombosis (HP:0002625)4.18420139
21Humeroradial synostosis (HP:0003041)4.16967063
22Synostosis involving the elbow (HP:0003938)4.16967063
23Lip pit (HP:0100267)4.16617903
24Decreased circulating renin level (HP:0003351)4.15605604
25Loss of speech (HP:0002371)4.08499670
26Bifid scrotum (HP:0000048)4.06546987
27Ulnar bowing (HP:0003031)4.05652268
28Glomerulonephritis (HP:0000099)4.04824245
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.86613644
30Recurrent bacterial skin infections (HP:0005406)3.84547978
31Abnormality of macrophages (HP:0004311)3.82614647
32Recurrent abscess formation (HP:0002722)3.73587371
33Chronic bronchitis (HP:0004469)3.72007320
34Mutism (HP:0002300)3.67744096
35Palpitations (HP:0001962)3.65492170
36Bronchiectasis (HP:0002110)3.59291584
37Abnormality of monocarboxylic acid metabolism (HP:0010996)3.50762460
38Abnormality of aromatic amino acid family metabolism (HP:0004338)3.50556034
39Nuclear cataract (HP:0100018)3.41099059
40Complement deficiency (HP:0004431)3.38176918
41Abnormality of mucopolysaccharide metabolism (HP:0011020)3.34596624
42Abnormality of polysaccharide metabolism (HP:0011012)3.34596624
43Abnormality of glycosaminoglycan metabolism (HP:0004371)3.34596624
44Xanthomatosis (HP:0000991)3.31368978
45Axonal loss (HP:0003447)3.29960360
46Intrahepatic cholestasis (HP:0001406)3.23866722
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.20753835
48Bronchomalacia (HP:0002780)3.20107916
49Recurrent sinusitis (HP:0011108)3.19962466
50Mucopolysacchariduria (HP:0008155)3.16247770
51Urinary glycosaminoglycan excretion (HP:0003541)3.16247770
52Severe Myopia (HP:0011003)3.13335366
53Syncope (HP:0001279)3.07631987
54Autoimmune thrombocytopenia (HP:0001973)3.02985845
55Poikilocytosis (HP:0004447)3.01800510
56Prolonged QT interval (HP:0001657)2.99502308
57Purpura (HP:0000979)2.95440146
58Vitreoretinal degeneration (HP:0000655)2.93895020
59Hypobetalipoproteinemia (HP:0003563)2.93546095
60Hyperlipoproteinemia (HP:0010980)2.88025218
61Eczematoid dermatitis (HP:0000976)2.86963763
62Recurrent gram-negative bacterial infections (HP:0005420)2.86312975
63Arterial tortuosity (HP:0005116)2.83158710
64Hyperglycinuria (HP:0003108)2.79982285
65Agnosia (HP:0010524)2.78583946
66Myositis (HP:0100614)2.75393434
67Increased serum ferritin (HP:0003281)2.70947501
68Heart block (HP:0012722)2.69428651
69Limb dystonia (HP:0002451)2.69030551
70Abnormality of dentin (HP:0010299)2.65298970
71Inappropriate behavior (HP:0000719)2.63014583
72Bowed forearm bones (HP:0003956)2.61457419
73Bowing of the arm (HP:0006488)2.61457419
74Orchitis (HP:0100796)2.57756449
75Apathy (HP:0000741)2.56693891
76Mediastinal lymphadenopathy (HP:0100721)2.56371965
77Torticollis (HP:0000473)2.56229287
78Amyloidosis (HP:0011034)2.55725950
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.55052113
80Abnormality of glutamine family amino acid metabolism (HP:0010902)2.54235010
81Metaphyseal irregularity (HP:0003025)2.53902282
82Abnormal atrioventricular conduction (HP:0005150)2.51779611
83Male infertility (HP:0003251)2.51177029
84Abnormality of serine family amino acid metabolism (HP:0010894)2.50688856
85Abnormality of glycine metabolism (HP:0010895)2.50688856
86Diminished motivation (HP:0000745)2.50644265
87Bell-shaped thorax (HP:0001591)2.50492258
88Vascular tortuosity (HP:0004948)2.48792198
89Vaginal fistula (HP:0004320)2.47436406
90Upper motor neuron abnormality (HP:0002127)2.46773723
91Neuronal loss in central nervous system (HP:0002529)2.44782215
92Retrobulbar optic neuritis (HP:0100654)2.44355815
93Optic neuritis (HP:0100653)2.44355815
94Hyperglycinemia (HP:0002154)2.44334149
95Hyperaldosteronism (HP:0000859)2.44057341
96Choanal stenosis (HP:0000452)2.39090218
97Abnormality of complement system (HP:0005339)2.36937588
98Ketosis (HP:0001946)2.36835256
99Stomatitis (HP:0010280)2.36522451
100Personality changes (HP:0000751)2.34592920
101Abnormality of the common coagulation pathway (HP:0010990)2.33805180
102Ketoacidosis (HP:0001993)2.31620134
103Abnormality of proline metabolism (HP:0010907)2.30516995
104Hydroxyprolinuria (HP:0003080)2.30516995
105Prolonged partial thromboplastin time (HP:0003645)2.30500568
106Abnormality of sodium homeostasis (HP:0010931)2.30193537
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.28484191
108Systemic lupus erythematosus (HP:0002725)2.27734837
109Tarsal synostosis (HP:0008368)2.27153340
110Retinal atrophy (HP:0001105)2.26154029
111Craniofacial dystonia (HP:0012179)2.24128320
112Hypolipoproteinemia (HP:0010981)2.23845985
113Dysphonia (HP:0001618)2.22522419
114Recurrent otitis media (HP:0000403)2.22241306
115Progressive neurologic deterioration (HP:0002344)2.21746074
116Hypoplastic ischia (HP:0003175)2.21207927
117Turricephaly (HP:0000262)2.21026696
118Protuberant abdomen (HP:0001538)2.19700144
119Abnormality of renin-angiotensin system (HP:0000847)2.18877922
120Femoral bowing (HP:0002980)2.17715777
121Epidermoid cyst (HP:0200040)2.15942870
122Synostosis involving bones of the lower limbs (HP:0009138)2.15839558
123Synostosis involving bones of the feet (HP:0009140)2.15839558
124Chronic sinusitis (HP:0011109)2.14896521
125Right ventricular cardiomyopathy (HP:0011663)2.14651240
126Fat malabsorption (HP:0002630)2.14516327
127Infertility (HP:0000789)2.12868232
128Bronchitis (HP:0012387)2.12853763
129Hyperammonemia (HP:0001987)2.12700674
130Delayed CNS myelination (HP:0002188)2.12348931
131Chronic obstructive pulmonary disease (HP:0006510)2.11966078
132Obstructive lung disease (HP:0006536)2.11966078
133Dementia (HP:0000726)2.11662609
134Hepatocellular carcinoma (HP:0001402)2.11137395
135Labial hypoplasia (HP:0000066)2.11054594
136Protrusio acetabuli (HP:0003179)2.09225797
137Cerebral inclusion bodies (HP:0100314)2.08807168
138Osteoarthritis (HP:0002758)2.08109434
139Abnormal cartilage morphology (HP:0002763)2.06332501
140Xerostomia (HP:0000217)2.06039547
141Hypoalphalipoproteinemia (HP:0003233)2.05091176
142Nephritis (HP:0000123)2.04631146
143Morphological abnormality of the middle ear (HP:0008609)2.04425091
144Chronic otitis media (HP:0000389)2.04225280
145Abnormality of iron homeostasis (HP:0011031)2.03908995
146Abnormality of the ischium (HP:0003174)2.02957434
147Mild short stature (HP:0003502)2.02065925
148Basal ganglia calcification (HP:0002135)2.02009433
149Focal dystonia (HP:0004373)2.01914931
150Hypothermia (HP:0002045)2.01725981
151Prolonged neonatal jaundice (HP:0006579)2.01701218
152Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01193975
153Abnormality of the vitreous humor (HP:0004327)2.01028853
154Malnutrition (HP:0004395)1.99916926
155Abnormal EKG (HP:0003115)1.99870546
156Anosmia (HP:0000458)1.99805932
157Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99189966
158Elevated erythrocyte sedimentation rate (HP:0003565)1.98910033
159Neurofibrillary tangles (HP:0002185)1.98661083
160Mixed hearing impairment (HP:0000410)1.98428719
161Hematochezia (HP:0002573)1.97041433
162Polydipsia (HP:0001959)1.95285257
163Abnormal drinking behavior (HP:0030082)1.95285257
164Myocardial infarction (HP:0001658)1.93538945
165Pulmonary embolism (HP:0002204)1.92461323
166Recurrent skin infections (HP:0001581)1.92208402
167Cholelithiasis (HP:0001081)1.89081683
168Carpal synostosis (HP:0009702)1.88607295
169Esophageal varix (HP:0002040)1.87777701
170Skin nodule (HP:0200036)1.87312231
171Pathologic fracture (HP:0002756)1.86303765
172Abnormality of macular pigmentation (HP:0008002)1.85023575
173Abnormality of the intrinsic pathway (HP:0010989)1.83886453
174Memory impairment (HP:0002354)1.83199219
175Renal tubular acidosis (HP:0001947)1.82719325
176Abnormal gallbladder morphology (HP:0012437)1.82565665
177Pulmonary infiltrates (HP:0002113)1.82455430
178Flattened epiphyses (HP:0003071)1.80157604
179Primary atrial arrhythmia (HP:0001692)1.79730901
180Hepatosplenomegaly (HP:0001433)1.78892518
181Asymmetric septal hypertrophy (HP:0001670)1.78416015
182Polyneuropathy (HP:0001271)1.77904689
183Supranuclear gaze palsy (HP:0000605)1.76048555
184Urinary incontinence (HP:0000020)1.70141196
185Thoracic kyphosis (HP:0002942)1.69712155
186Gingivitis (HP:0000230)1.69174571
187Abnormality of transition element cation homeostasis (HP:0011030)1.67595639
188Hemoptysis (HP:0002105)1.67223233
189Abnormality of the periventricular white matter (HP:0002518)1.66610967
190Spontaneous hematomas (HP:0007420)1.66508936
191Petechiae (HP:0000967)1.66381151
192Atelectasis (HP:0100750)1.66340680
193Peripheral demyelination (HP:0011096)1.64492761
194Interstitial pulmonary disease (HP:0006530)1.63445943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.14866215
2NME24.24146409
3IRAK33.91557738
4MAPK153.45452121
5LATS13.45013299
6BLK3.18836719
7STK163.09248020
8GRK72.87094851
9TBK12.75848417
10TRIB32.75497170
11MAP3K112.63098402
12PAK32.61262661
13TYRO32.59908094
14ERBB32.50952122
15SIK12.48741029
16MAP3K32.43548139
17TAOK22.28334629
18RIPK12.10299426
19MATK2.10026676
20TAOK12.08102119
21RIPK41.96516150
22EPHA31.93880166
23CAMK2D1.93709867
24STK391.90485401
25CAMK2B1.89091901
26FGR1.86362021
27IKBKB1.82598950
28DAPK21.82267241
29PIM21.80874038
30PKN21.77754928
31ABL21.71890193
32SIK21.70723174
33EPHB11.69809131
34ACVR1B1.69524932
35FER1.66975995
36LMTK21.64536403
37DYRK1B1.62275564
38CAMK2G1.58505189
39IKBKE1.55250050
40NTRK11.53344045
41PTK61.49252779
42IRAK41.46206313
43FGFR41.43331688
44CSNK1A1L1.41855480
45BCKDK1.41193201
46HIPK21.39604496
47ERN11.37460038
48FRK1.35698528
49CDC42BPA1.33671317
50MAP2K31.32216156
51MAP4K11.31660035
52GRK61.27956037
53ADRBK21.26262427
54CAMKK21.25352169
55TGFBR21.21608422
56ZAP701.19341600
57JAK31.19190438
58CSNK1G31.17161396
59MAP3K101.14789195
60MAP3K71.14296990
61MST1R1.13764521
62CSNK1G11.13000077
63TRPM71.09762074
64MAPKAPK31.09309596
65MOS1.07470497
66CSNK1G21.07390758
67MAP3K21.05568046
68CSF1R1.05549820
69CHUK1.03963657
70LYN1.01197202
71NUAK10.98762320
72MAP3K10.98234678
73MAP2K10.95455651
74PAK60.90312266
75LRRK20.89320887
76CDK60.89163548
77TXK0.87937475
78PDGFRA0.87817483
79PRKCG0.86387873
80MAP3K140.85469121
81MAP2K40.84450816
82SYK0.82958136
83SMG10.80939694
84KSR20.79381808
85ALK0.77467241
86ARAF0.76352240
87ITK0.76287868
88FES0.75213449
89MARK30.74275092
90ERBB20.72180242
91MARK20.71774931
92PRPF4B0.71388208
93MAP3K130.71173740
94TGFBR10.70759844
95SIK30.70620528
96BMPR20.70362059
97EPHB20.69860377
98EEF2K0.69269317
99MET0.69118103
100JAK20.68518812
101INSRR0.67102341
102PRKD10.65933510
103EPHA20.65849606
104WNK40.65376075
105MAP3K50.65061606
106STK100.65031147
107TESK20.64006675
108FGFR20.63616889
109PRKG20.63542549
110STK30.63524505
111PRKCH0.62565040
112CAMK1D0.62235932
113ERBB40.61808981
114TESK10.60909220
115MAP2K20.59958831
116MAP2K60.59890190
117PDK20.59586415
118PTK20.58097839
119OXSR10.57937281
120LCK0.57633323
121PDPK10.56879972
122CAMK2A0.56518778
123ROCK20.53793565
124STK240.53762413
125PINK10.53166893
126JAK10.52722167
127MINK10.52549951
128RET0.52097725
129TNK20.51969099
130ILK0.51801027
131PRKCI0.51676775
132BTK0.50667995
133BMX0.50649073
134PRKCZ0.50217946
135DMPK0.49925593
136CSK0.48944166
137IRAK20.47804110
138HCK0.47240928
139TYK20.46161559
140PAK40.45175243
141ABL10.44022568
142FYN0.42714593
143IRAK10.41685496
144ICK0.41374469
145DYRK30.41101280
146CAMKK10.40672497
147PRKCD0.40398753
148RPS6KL10.40359383
149RPS6KC10.40359383
150MAPK40.39178291
151FGFR30.38613803
152PDK30.37916159
153PDK40.37916159
154PRKD30.37834875
155CDK50.37111302
156PAK20.36503499
157RPS6KB20.36321270
158KIT0.35782448
159MAP3K40.34219113
160NEK90.33662172
161PRKACG0.33077131
162PHKG10.32748431
163PHKG20.32748431
164MAP3K120.31606148
165RPS6KA60.31436635
166TTN0.31222508
167PDK10.30761822
168PAK10.30385289
169RPS6KA20.30302007
170MST40.30284139
171LIMK10.30101335
172PKN10.25647313
173TLK10.24996631
174EGFR0.24668775

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.02286358
2Other glycan degradation_Homo sapiens_hsa005113.90731859
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.64716156
4Lysosome_Homo sapiens_hsa041423.48288363
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.41315701
6Caffeine metabolism_Homo sapiens_hsa002323.08904284
7Rheumatoid arthritis_Homo sapiens_hsa053232.94767391
8Asthma_Homo sapiens_hsa053102.93298251
9Allograft rejection_Homo sapiens_hsa053302.77600113
10Histidine metabolism_Homo sapiens_hsa003402.61526330
11Glutathione metabolism_Homo sapiens_hsa004802.56391685
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.54663499
13Osteoclast differentiation_Homo sapiens_hsa043802.48114571
14Butanoate metabolism_Homo sapiens_hsa006502.45499468
15Graft-versus-host disease_Homo sapiens_hsa053322.41230275
16Leishmaniasis_Homo sapiens_hsa051402.34218142
17Autoimmune thyroid disease_Homo sapiens_hsa053202.33630429
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31775886
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31268787
20Primary bile acid biosynthesis_Homo sapiens_hsa001202.27219001
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25824721
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24677527
23Sulfur metabolism_Homo sapiens_hsa009202.23128560
24Intestinal immune network for IgA production_Homo sapiens_hsa046722.21049306
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20284895
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.09918139
27Pertussis_Homo sapiens_hsa051332.09413431
28Tuberculosis_Homo sapiens_hsa051522.06743576
29Cyanoamino acid metabolism_Homo sapiens_hsa004602.05987302
30beta-Alanine metabolism_Homo sapiens_hsa004102.04235678
31Steroid hormone biosynthesis_Homo sapiens_hsa001402.04093379
32Thyroid hormone synthesis_Homo sapiens_hsa049181.97914967
33Nitrogen metabolism_Homo sapiens_hsa009101.93140546
34Type I diabetes mellitus_Homo sapiens_hsa049401.92975641
35Chemical carcinogenesis_Homo sapiens_hsa052041.92499337
36Antigen processing and presentation_Homo sapiens_hsa046121.91573465
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90640854
38Phagosome_Homo sapiens_hsa041451.81575890
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.79080759
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76293725
41Malaria_Homo sapiens_hsa051441.73937564
42Bile secretion_Homo sapiens_hsa049761.69667828
43Arginine biosynthesis_Homo sapiens_hsa002201.65072762
44Tryptophan metabolism_Homo sapiens_hsa003801.64528674
45Legionellosis_Homo sapiens_hsa051341.54619591
46TNF signaling pathway_Homo sapiens_hsa046681.53789037
47Arachidonic acid metabolism_Homo sapiens_hsa005901.53510413
48Salmonella infection_Homo sapiens_hsa051321.51023376
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49476971
50Fatty acid degradation_Homo sapiens_hsa000711.48304747
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48143804
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45037494
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39643955
54Toxoplasmosis_Homo sapiens_hsa051451.39194293
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.36649596
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28778212
57Viral myocarditis_Homo sapiens_hsa054161.26835734
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26717360
59Retinol metabolism_Homo sapiens_hsa008301.26603610
60Phenylalanine metabolism_Homo sapiens_hsa003601.25558640
61Hematopoietic cell lineage_Homo sapiens_hsa046401.23695015
62Sphingolipid metabolism_Homo sapiens_hsa006001.22848167
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22325228
64Starch and sucrose metabolism_Homo sapiens_hsa005001.20711700
65Propanoate metabolism_Homo sapiens_hsa006401.18695757
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15598429
67Influenza A_Homo sapiens_hsa051641.15454568
68Pyruvate metabolism_Homo sapiens_hsa006201.09278639
69Complement and coagulation cascades_Homo sapiens_hsa046101.08912622
70Vibrio cholerae infection_Homo sapiens_hsa051101.06649742
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06637835
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04514240
73ABC transporters_Homo sapiens_hsa020101.04154671
74Sulfur relay system_Homo sapiens_hsa041220.98731327
75Salivary secretion_Homo sapiens_hsa049700.98536321
76African trypanosomiasis_Homo sapiens_hsa051430.95751824
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95562592
78PPAR signaling pathway_Homo sapiens_hsa033200.94036993
79B cell receptor signaling pathway_Homo sapiens_hsa046620.88034514
80Hepatitis C_Homo sapiens_hsa051600.87940140
81Herpes simplex infection_Homo sapiens_hsa051680.86067047
82Selenocompound metabolism_Homo sapiens_hsa004500.84885850
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84341317
84Arginine and proline metabolism_Homo sapiens_hsa003300.82982865
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82297786
86Chemokine signaling pathway_Homo sapiens_hsa040620.81789567
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80984266
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78501652
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78281258
90Peroxisome_Homo sapiens_hsa041460.76927384
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75392617
92Gastric acid secretion_Homo sapiens_hsa049710.73308492
93Apoptosis_Homo sapiens_hsa042100.72928565
94Tyrosine metabolism_Homo sapiens_hsa003500.71691061
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71437350
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70598230
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.68398622
98Fatty acid metabolism_Homo sapiens_hsa012120.67906459
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67280638
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66003750
101Bladder cancer_Homo sapiens_hsa052190.64240396
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64140479
103Staphylococcus aureus infection_Homo sapiens_hsa051500.64128904
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.62999882
105Ovarian steroidogenesis_Homo sapiens_hsa049130.62124257
106Morphine addiction_Homo sapiens_hsa050320.61764973
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61639106
108Shigellosis_Homo sapiens_hsa051310.60993145
109Collecting duct acid secretion_Homo sapiens_hsa049660.60422808
110Measles_Homo sapiens_hsa051620.58345879
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.57585699
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56404760
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56239945
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51950754
115Fatty acid biosynthesis_Homo sapiens_hsa000610.50944061
116Insulin secretion_Homo sapiens_hsa049110.47723694
117Estrogen signaling pathway_Homo sapiens_hsa049150.47297846
118Acute myeloid leukemia_Homo sapiens_hsa052210.46950575
119Galactose metabolism_Homo sapiens_hsa000520.46872781
120Circadian entrainment_Homo sapiens_hsa047130.46621541
121GABAergic synapse_Homo sapiens_hsa047270.44298561
122Hepatitis B_Homo sapiens_hsa051610.43966105
123Epstein-Barr virus infection_Homo sapiens_hsa051690.41416776
124Endocytosis_Homo sapiens_hsa041440.38880638
125T cell receptor signaling pathway_Homo sapiens_hsa046600.38342193
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.38295984
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36946031
128cAMP signaling pathway_Homo sapiens_hsa040240.36844277
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36426583
130Systemic lupus erythematosus_Homo sapiens_hsa053220.36124565
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35455384
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35221762
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35032336
134Dopaminergic synapse_Homo sapiens_hsa047280.34921944
135Synaptic vesicle cycle_Homo sapiens_hsa047210.34785391
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34764963
137Notch signaling pathway_Homo sapiens_hsa043300.31152299
138Melanogenesis_Homo sapiens_hsa049160.30522854
139Prion diseases_Homo sapiens_hsa050200.29307416
140VEGF signaling pathway_Homo sapiens_hsa043700.28995459
141Amoebiasis_Homo sapiens_hsa051460.28069341
142Primary immunodeficiency_Homo sapiens_hsa053400.28018701
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25139350
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24925992
145Fructose and mannose metabolism_Homo sapiens_hsa000510.24682256
146Prolactin signaling pathway_Homo sapiens_hsa049170.24419692
147Protein digestion and absorption_Homo sapiens_hsa049740.24419425
148Taste transduction_Homo sapiens_hsa047420.23929054
149Carbon metabolism_Homo sapiens_hsa012000.23827722
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.23818765
151Axon guidance_Homo sapiens_hsa043600.23162227
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.21899155
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21866371
154Insulin resistance_Homo sapiens_hsa049310.20404248
155Biosynthesis of amino acids_Homo sapiens_hsa012300.20390724
156cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19503881
157Cholinergic synapse_Homo sapiens_hsa047250.19151399
158Linoleic acid metabolism_Homo sapiens_hsa005910.18331195
159Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18015983
160Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17916310
161Dilated cardiomyopathy_Homo sapiens_hsa054140.17749504
162HTLV-I infection_Homo sapiens_hsa051660.17429759
163Dorso-ventral axis formation_Homo sapiens_hsa043200.17125617
164Fat digestion and absorption_Homo sapiens_hsa049750.16624127
165Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16337207
166Glutamatergic synapse_Homo sapiens_hsa047240.16288806
167Hippo signaling pathway_Homo sapiens_hsa043900.15637326
168Mineral absorption_Homo sapiens_hsa049780.15368677
169GnRH signaling pathway_Homo sapiens_hsa049120.14259605
170Lysine degradation_Homo sapiens_hsa003100.13200250
171Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12452496
172Glycerolipid metabolism_Homo sapiens_hsa005610.12069062
173Pancreatic secretion_Homo sapiens_hsa049720.11938077
174Type II diabetes mellitus_Homo sapiens_hsa049300.04288189

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