VIT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an extracellular matrix (ECM) protein. The protein may be associated with cell adhesion and migration. High levels of expression of the protein in specific parts of the brain suggest its likely role in neural development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lens development in camera-type eye (GO:0002088)8.00886822
2polyketide metabolic process (GO:0030638)6.49304016
3doxorubicin metabolic process (GO:0044598)6.49304016
4daunorubicin metabolic process (GO:0044597)6.49304016
5lens fiber cell differentiation (GO:0070306)5.86002902
6cilium or flagellum-dependent cell motility (GO:0001539)5.38145569
7lens fiber cell development (GO:0070307)5.17478959
8protein heterotrimerization (GO:0070208)4.85874473
9muscle filament sliding (GO:0030049)4.64501519
10actin-myosin filament sliding (GO:0033275)4.64501519
11axonemal dynein complex assembly (GO:0070286)4.53502294
12cilium movement (GO:0003341)4.52926018
13collagen fibril organization (GO:0030199)4.41611476
14protein-chromophore linkage (GO:0018298)4.39779647
15extracellular matrix assembly (GO:0085029)4.27145680
16type B pancreatic cell proliferation (GO:0044342)4.19828662
17sphingosine metabolic process (GO:0006670)4.18388881
18actin-mediated cell contraction (GO:0070252)4.16674171
19cardiac myofibril assembly (GO:0055003)4.12169322
20response to pheromone (GO:0019236)4.06058514
21mesenchymal-epithelial cell signaling (GO:0060638)3.97073826
22paraxial mesoderm development (GO:0048339)3.95736348
23detection of molecule of bacterial origin (GO:0032490)3.91180068
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.90389164
25epithelial cilium movement (GO:0003351)3.85949874
26myofibril assembly (GO:0030239)3.84587062
27aminoglycoside antibiotic metabolic process (GO:0030647)3.83541346
28glomerular basement membrane development (GO:0032836)3.79953688
29motile cilium assembly (GO:0044458)3.78071499
30axoneme assembly (GO:0035082)3.75018326
31cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.73643304
32regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.73165905
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.72790126
34axon extension involved in axon guidance (GO:0048846)3.72790126
35diol metabolic process (GO:0034311)3.70219329
36sphingoid metabolic process (GO:0046519)3.64169219
37cell migration involved in heart development (GO:0060973)3.62122575
38extracellular fibril organization (GO:0043206)3.57044355
39keratan sulfate catabolic process (GO:0042340)3.53649872
40peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.49996605
41inner ear receptor stereocilium organization (GO:0060122)3.49307132
42negative regulation of BMP signaling pathway (GO:0030514)3.44533395
43response to epinephrine (GO:0071871)3.44426801
44regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.42334813
45sarcomere organization (GO:0045214)3.37513807
46negative regulation of smooth muscle cell migration (GO:0014912)3.36836206
47sequestering of extracellular ligand from receptor (GO:0035581)3.31691832
48negative regulation of focal adhesion assembly (GO:0051895)3.30790601
49negative regulation of cell junction assembly (GO:1901889)3.30790601
50negative regulation of adherens junction organization (GO:1903392)3.30790601
51energy homeostasis (GO:0097009)3.26032300
52vitamin A metabolic process (GO:0006776)3.22609831
53negative regulation of homotypic cell-cell adhesion (GO:0034111)3.21840699
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21609693
55adhesion of symbiont to host cell (GO:0044650)3.21479368
56virion attachment to host cell (GO:0019062)3.21479368
57auditory receptor cell stereocilium organization (GO:0060088)3.20870753
58actin filament-based movement (GO:0030048)3.16705189
59endodermal cell differentiation (GO:0035987)3.13471340
60heart process (GO:0003015)3.12727230
61heart contraction (GO:0060047)3.12727230
62sulfate transmembrane transport (GO:1902358)3.12200562
63regulation of sequestering of triglyceride (GO:0010889)3.12058051
64collagen metabolic process (GO:0032963)3.08678933
65regulation of gonadotropin secretion (GO:0032276)3.05313590
66kidney mesenchyme development (GO:0072074)3.04625531
67lens morphogenesis in camera-type eye (GO:0002089)3.04477969
68regulation of mesenchymal cell apoptotic process (GO:2001053)3.04056307
69limb bud formation (GO:0060174)3.03086739
70regulation of protein sumoylation (GO:0033233)3.00794535
71fibril organization (GO:0097435)3.00748709
72regulation of podosome assembly (GO:0071801)3.00625324
73negative regulation of axon guidance (GO:1902668)2.99766135
74barbed-end actin filament capping (GO:0051016)2.98106840
75smooth muscle tissue development (GO:0048745)2.97584333
76vascular endothelial growth factor signaling pathway (GO:0038084)2.97387963
77collagen catabolic process (GO:0030574)2.96272344
78negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.94918989
79basement membrane organization (GO:0071711)2.94571304
80negative regulation of chondrocyte differentiation (GO:0032331)2.92544758
81heart valve formation (GO:0003188)2.89387706
82sarcoplasmic reticulum calcium ion transport (GO:0070296)2.89175378
83regulation of plasminogen activation (GO:0010755)2.88125502
84actomyosin structure organization (GO:0031032)2.88022952
85intraciliary transport (GO:0042073)2.87720080
86endocardial cushion development (GO:0003197)2.84485514
87multicellular organismal macromolecule metabolic process (GO:0044259)2.84269036
88mesenchyme morphogenesis (GO:0072132)2.84035323
89retina vasculature morphogenesis in camera-type eye (GO:0061299)2.83365299
90acrosome reaction (GO:0007340)2.83278337
91bone trabecula formation (GO:0060346)2.82986883
92sulfate transport (GO:0008272)2.82265051
93adhesion of symbiont to host (GO:0044406)2.78819700
94epithelial cell-cell adhesion (GO:0090136)2.78300829
95regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78237696
96establishment of planar polarity (GO:0001736)2.76436080
97establishment of tissue polarity (GO:0007164)2.76436080
98cornea development in camera-type eye (GO:0061303)2.76297626
99regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.76255132
100ventricular system development (GO:0021591)2.76203261
101negative regulation of cell-matrix adhesion (GO:0001953)2.74925170
102visual perception (GO:0007601)2.74516739
103sensory perception of light stimulus (GO:0050953)2.73699843
104positive regulation of cellular amide metabolic process (GO:0034250)2.73289127
105multicellular organismal metabolic process (GO:0044236)2.73252577
106regulation of somitogenesis (GO:0014807)2.72374726
107phagocytosis, recognition (GO:0006910)2.72028856
108negative regulation of protein localization to cell surface (GO:2000009)2.71659245
109prostate gland growth (GO:0060736)2.71262854
110positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.71098924
111cell proliferation involved in kidney development (GO:0072111)2.70798332
112positive regulation of fatty acid oxidation (GO:0046321)2.69254083
113multicellular organismal catabolic process (GO:0044243)2.67770177
114regulation of cardiac muscle cell differentiation (GO:2000725)2.67417654
115lateral sprouting from an epithelium (GO:0060601)2.66292630
116dermatan sulfate biosynthetic process (GO:0030208)2.65897571
117sperm motility (GO:0030317)2.65435664
118left/right axis specification (GO:0070986)2.62411976
119negative regulation of smooth muscle cell proliferation (GO:0048662)2.62009576
120atrial cardiac muscle cell action potential (GO:0086014)2.61946554
121regulation of skeletal muscle contraction (GO:0014819)2.61604974
122kidney morphogenesis (GO:0060993)2.61341980
123multicellular organism reproduction (GO:0032504)2.61050006
124embryonic cranial skeleton morphogenesis (GO:0048701)2.59723509
125planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59559720
126* extracellular matrix organization (GO:0030198)2.59030676
127* extracellular structure organization (GO:0043062)2.58078869
128ganglion development (GO:0061548)2.57204285
129regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56985579
130blood vessel maturation (GO:0001955)2.56973696
131extracellular matrix disassembly (GO:0022617)2.56367806
132negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.56178795
133piRNA metabolic process (GO:0034587)2.55891467
134cellular response to vitamin (GO:0071295)2.55824144
135cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.55169257
136middle ear morphogenesis (GO:0042474)2.54531995
137positive regulation of catecholamine secretion (GO:0033605)2.54427877
138regulation of integrin-mediated signaling pathway (GO:2001044)2.54006391
139regulation of male gonad development (GO:2000018)2.53946254
140dermatan sulfate metabolic process (GO:0030205)2.53851148
141metanephric mesenchyme development (GO:0072075)2.53809639
142cardiac muscle contraction (GO:0060048)2.53585257
143eye photoreceptor cell differentiation (GO:0001754)2.53350780
144photoreceptor cell differentiation (GO:0046530)2.53350780
145cell-substrate junction assembly (GO:0007044)2.51838288
146cell-substrate adherens junction assembly (GO:0007045)2.51377643
147focal adhesion assembly (GO:0048041)2.51377643
148response to muscle activity (GO:0014850)2.51344410
149cellular response to electrical stimulus (GO:0071257)2.49479610
150mechanoreceptor differentiation (GO:0042490)2.48130656
151negative regulation of axon extension involved in axon guidance (GO:0048843)2.47986158
152protein localization to cell surface (GO:0034394)2.47565369
153negative regulation of stem cell proliferation (GO:2000647)2.47345256
154muscle cell cellular homeostasis (GO:0046716)2.47342270
155epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.47216433
156regulation of the force of heart contraction (GO:0002026)2.47167555
157negative regulation of heart growth (GO:0061117)2.45838876
158negative regulation of cardiac muscle tissue growth (GO:0055022)2.45838876
159positive regulation of smoothened signaling pathway (GO:0045880)2.45407155
160lateral ventricle development (GO:0021670)2.45052256
161detection of external biotic stimulus (GO:0098581)2.44672616
162acrosome assembly (GO:0001675)2.44569757
163regulation of cilium movement (GO:0003352)2.43552245
164negative chemotaxis (GO:0050919)2.43230253
165muscle contraction (GO:0006936)2.41843321
166regulation of BMP signaling pathway (GO:0030510)2.40862465
167male meiosis (GO:0007140)2.40854509
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40852064
169negative regulation of myoblast differentiation (GO:0045662)2.39345710
170cilium organization (GO:0044782)2.38500932
171dentate gyrus development (GO:0021542)2.38018609
172nonmotile primary cilium assembly (GO:0035058)2.37839122
173cerebral cortex radially oriented cell migration (GO:0021799)2.37814630
174cilium assembly (GO:0042384)2.37035540
175extracellular regulation of signal transduction (GO:1900115)2.36671797
176extracellular negative regulation of signal transduction (GO:1900116)2.36671797
177notochord development (GO:0030903)2.36623962
178regulation of myoblast differentiation (GO:0045661)2.35618263
179eye development (GO:0001654)2.34041247
180cell proliferation involved in metanephros development (GO:0072203)2.33488755
181negative regulation of osteoblast proliferation (GO:0033689)2.33353806
182female gonad development (GO:0008585)2.33252502
183positive regulation of male gonad development (GO:2000020)2.32791361
184cellular anion homeostasis (GO:0030002)2.31250213
185DNA methylation involved in gamete generation (GO:0043046)2.30844232
186mesenchymal cell differentiation involved in kidney development (GO:0072161)2.29246872
187mesenchymal cell differentiation involved in renal system development (GO:2001012)2.29246872
188serotonin receptor signaling pathway (GO:0007210)2.29224213
189chondrocyte proliferation (GO:0035988)2.27574303
190neuronal ion channel clustering (GO:0045161)2.26331110
191urinary tract smooth muscle contraction (GO:0014848)2.26290204
192endocardial cushion morphogenesis (GO:0003203)2.24758008
193postsynaptic membrane organization (GO:0001941)2.24603567
194regulation of axon guidance (GO:1902667)2.23239844
195camera-type eye development (GO:0043010)2.23230444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39975329
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.67115051
3GBX2_23144817_ChIP-Seq_PC3_Human3.13082631
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.05472219
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54289069
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.54157192
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.48857623
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44790860
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37529982
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.27431145
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.25416285
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19722932
13CJUN_26792858_Chip-Seq_BT549_Human2.18653292
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17774051
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15710148
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15333961
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12953984
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12953984
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11808177
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10526199
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.06608832
22* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05191775
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02020392
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.96298669
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.96004421
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93628668
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92160664
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.91025822
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.87657938
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.87657938
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.86364933
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85159972
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83229637
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82508778
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.82287741
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80880343
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80148513
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78889076
39BRD4_25478319_ChIP-Seq_HGPS_Human1.75775072
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75432061
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75303532
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.69235001
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68940990
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.68632824
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63829582
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61672433
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58723108
48P300_19829295_ChIP-Seq_ESCs_Human1.58701055
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58170771
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55693619
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54191902
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53265705
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52998683
54RNF2_27304074_Chip-Seq_NSC_Mouse1.51752100
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.50833207
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49804955
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49804955
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.49351869
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.45478378
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.45129430
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44453260
62SMAD4_21799915_ChIP-Seq_A2780_Human1.43691326
63P53_22387025_ChIP-Seq_ESCs_Mouse1.42815995
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.42276327
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39383136
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.38233311
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37226664
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.36450679
69TP53_18474530_ChIP-ChIP_U2OS_Human1.36113806
70CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.33462189
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.33392729
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32768982
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32705595
74TP53_16413492_ChIP-PET_HCT116_Human1.32355554
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32218999
76* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31126394
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30757737
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30156089
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.29952370
80STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.28734798
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.28530458
82IGF1R_20145208_ChIP-Seq_DFB_Human1.27881656
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27849265
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27343550
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26757918
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26757918
87* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26215281
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26025793
89FUS_26573619_Chip-Seq_HEK293_Human1.25798865
90DROSHA_22980978_ChIP-Seq_HELA_Human1.25403239
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25009972
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24695069
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24671007
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23974498
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23472080
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22908719
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.22407002
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22160708
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.21899738
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21657955
101TAF15_26573619_Chip-Seq_HEK293_Human1.21485618
102RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20896520
103AR_25329375_ChIP-Seq_VCAP_Human1.19767821
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.19601625
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.19265878
106SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18080340
107PU1_27457419_Chip-Seq_LIVER_Mouse1.17648821
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17344597
109ER_23166858_ChIP-Seq_MCF-7_Human1.17230188
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16640431
111P300_18555785_Chip-Seq_ESCs_Mouse1.16274331
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.14645399
113SA1_22415368_ChIP-Seq_MEFs_Mouse1.13657271
114ZFX_18555785_Chip-Seq_ESCs_Mouse1.12952479
115AR_21572438_ChIP-Seq_LNCaP_Human1.12797393
116REST_21632747_ChIP-Seq_MESCs_Mouse1.12721021
117CLOCK_20551151_ChIP-Seq_293T_Human1.12688055
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12205528
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11577990
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10978156
121NMYC_18555785_Chip-Seq_ESCs_Mouse1.10312767
122OCT4_18555785_Chip-Seq_ESCs_Mouse1.09816207
123CTCF_18555785_Chip-Seq_ESCs_Mouse1.09612696
124KLF4_18555785_Chip-Seq_ESCs_Mouse1.09277887
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09101298
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08222206
127WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07765561
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07044567
129ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06389648
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06119101
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05938732
132NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05661432
133* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05573759
134RING1B_27294783_Chip-Seq_NPCs_Mouse1.05493249
135RUNX2_22187159_ChIP-Seq_PCA_Human1.05345185
136TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05220256
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04004198
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03895114
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03364612
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02964912
141* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01846843
142TP53_23651856_ChIP-Seq_MEFs_Mouse1.01730290
143NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01060887
144AHR_22903824_ChIP-Seq_MCF-7_Human1.00926220
145TBL1_22424771_ChIP-Seq_293T_Human1.00126068
146ESR1_21235772_ChIP-Seq_MCF-7_Human0.99183956
147SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99060597
148MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96428033
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95868832
150SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94948514
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91645013
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.91425486
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.90728019
154* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88358313
155EGR1_19032775_ChIP-ChIP_M12_Human0.87842255
156* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84375842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.87746900
2MP0002837_dystrophic_cardiac_calcinosis3.86856291
3MP0002697_abnormal_eye_size3.83448738
4MP0003705_abnormal_hypodermis_morpholog3.75849495
5MP0003011_delayed_dark_adaptation3.71352464
6MP0005503_abnormal_tendon_morphology3.30372905
7MP0001958_emphysema3.21839481
8MP0000751_myopathy3.15615121
9MP0006292_abnormal_olfactory_placode3.05363741
10MP0003646_muscle_fatigue2.87968306
11MP0005171_absent_coat_pigmentation2.83282968
12MP0005257_abnormal_intraocular_pressure2.81284698
13MP0000749_muscle_degeneration2.74178793
14MP0005646_abnormal_pituitary_gland2.49441994
15MP0004084_abnormal_cardiac_muscle2.44472884
16MP0001346_abnormal_lacrimal_gland2.43441939
17MP0002638_abnormal_pupillary_reflex2.40554257
18MP0003941_abnormal_skin_development2.40334820
19MP0005670_abnormal_white_adipose2.31378685
20MP0004036_abnormal_muscle_relaxation2.25390618
21MP0005193_abnormal_anterior_eye2.14114103
22MP0005377_hearing/vestibular/ear_phenot2.09340313
23MP0003878_abnormal_ear_physiology2.09340313
24MP0002249_abnormal_larynx_morphology2.02623781
25MP0008004_abnormal_stomach_pH2.02249198
26MP0010030_abnormal_orbit_morphology2.02019938
27MP0002735_abnormal_chemical_nociception1.97845952
28MP0005410_abnormal_fertilization1.91693527
29MP0003045_fibrosis1.91051279
30MP0008789_abnormal_olfactory_epithelium1.89172345
31MP0000049_abnormal_middle_ear1.88823693
32MP0003136_yellow_coat_color1.86471176
33MP0008438_abnormal_cutaneous_collagen1.85844376
34MP0000678_abnormal_parathyroid_gland1.83097141
35MP0004130_abnormal_muscle_cell1.82804971
36MP0002938_white_spotting1.80055623
37MP0000759_abnormal_skeletal_muscle1.77545818
38MP0001984_abnormal_olfaction1.75138722
39MP0009250_abnormal_appendicular_skeleto1.74113023
40MP0004233_abnormal_muscle_weight1.71909486
41MP0005330_cardiomyopathy1.68117539
42MP0010368_abnormal_lymphatic_system1.67389038
43MP0005253_abnormal_eye_physiology1.66155497
44MP0005275_abnormal_skin_tensile1.64590938
45MP0006054_spinal_hemorrhage1.63678668
46MP0005645_abnormal_hypothalamus_physiol1.62985836
47MP0002736_abnormal_nociception_after1.61365210
48MP0005394_taste/olfaction_phenotype1.58129330
49MP0005499_abnormal_olfactory_system1.58129330
50MP0002108_abnormal_muscle_morphology1.57161310
51MP0003950_abnormal_plasma_membrane1.54623088
52MP0001188_hyperpigmentation1.51404869
53MP0002233_abnormal_nose_morphology1.50412647
54MP0005197_abnormal_uvea_morphology1.49575625
55MP0004087_abnormal_muscle_fiber1.49555726
56MP0006138_congestive_heart_failure1.49046561
57MP0005620_abnormal_muscle_contractility1.47978725
58MP0002269_muscular_atrophy1.44017115
59MP0001286_abnormal_eye_development1.41172433
60MP0000013_abnormal_adipose_tissue1.37684165
61MP0002102_abnormal_ear_morphology1.34551115
62MP0003385_abnormal_body_wall1.33264878
63MP0009780_abnormal_chondrocyte_physiolo1.33218302
64MP0000767_abnormal_smooth_muscle1.32931841
65MP0002060_abnormal_skin_morphology1.32911700
66MP0005369_muscle_phenotype1.32903371
67MP0002277_abnormal_respiratory_mucosa1.30840671
68MP0005508_abnormal_skeleton_morphology1.30767362
69MP0001968_abnormal_touch/_nociception1.28752282
70MP0000778_abnormal_nervous_system1.26951534
71MP0000569_abnormal_digit_pigmentation1.26316348
72MP0001542_abnormal_bone_strength1.25294374
73MP0002282_abnormal_trachea_morphology1.25105298
74MP0010386_abnormal_urinary_bladder1.24014320
75MP0004145_abnormal_muscle_electrophysio1.23523787
76MP0002254_reproductive_system_inflammat1.23298469
77MP0004215_abnormal_myocardial_fiber1.23206308
78MP0001661_extended_life_span1.20772723
79MP0004270_analgesia1.20327083
80MP0002106_abnormal_muscle_physiology1.18931273
81MP0006276_abnormal_autonomic_nervous1.18785338
82MP0001502_abnormal_circadian_rhythm1.18432052
83MP0003828_pulmonary_edema1.16304156
84MP0000762_abnormal_tongue_morphology1.15694504
85MP0003283_abnormal_digestive_organ1.15347937
86MP0000026_abnormal_inner_ear1.14611716
87MP0000372_irregular_coat_pigmentation1.13542664
88MP0004858_abnormal_nervous_system1.13152488
89MP0000747_muscle_weakness1.13062485
90MP0003879_abnormal_hair_cell1.12381217
91MP0002971_abnormal_brown_adipose1.11402142
92MP0004134_abnormal_chest_morphology1.11278696
93MP0005666_abnormal_adipose_tissue1.10241235
94MP0000750_abnormal_muscle_regeneration1.09948789
95MP0005391_vision/eye_phenotype1.09527843
96MP0002557_abnormal_social/conspecific_i1.08229729
97MP0005023_abnormal_wound_healing1.08111546
98MP0005248_abnormal_Harderian_gland1.07351145
99MP0002116_abnormal_craniofacial_bone1.07069310
100MP0005623_abnormal_meninges_morphology1.06996746
101MP0002972_abnormal_cardiac_muscle1.06926528
102MP0002090_abnormal_vision1.04682447
103MP0002896_abnormal_bone_mineralization1.03464798
104MP0003942_abnormal_urinary_system1.02706581
105MP0000631_abnormal_neuroendocrine_gland1.01833639
106MP0001544_abnormal_cardiovascular_syste1.01669344
107MP0005385_cardiovascular_system_phenoty1.01669344
108MP0001986_abnormal_taste_sensitivity1.01635913
109MP0000681_abnormal_thyroid_gland1.01227850
110MP0005375_adipose_tissue_phenotype1.00424802
111MP0004742_abnormal_vestibular_system1.00184950
112MP0002653_abnormal_ependyma_morphology1.00163650
113MP0003279_aneurysm0.99509751
114MP0003137_abnormal_impulse_conducting0.98895369
115MP0002751_abnormal_autonomic_nervous0.98457982
116MP0002177_abnormal_outer_ear0.96522677
117MP0005595_abnormal_vascular_smooth0.96383888
118MP0002168_other_aberrant_phenotype0.96239366
119MP0001486_abnormal_startle_reflex0.95597998
120MP0001501_abnormal_sleep_pattern0.94967544
121MP0002092_abnormal_eye_morphology0.94888738
122MP0008007_abnormal_cellular_replicative0.94372311
123MP0000003_abnormal_adipose_tissue0.93138595
124MP0000163_abnormal_cartilage_morphology0.92664135
125MP0003091_abnormal_cell_migration0.92421746
126MP0004859_abnormal_synaptic_plasticity0.91766347
127MP0003566_abnormal_cell_adhesion0.91721823
128MP0003938_abnormal_ear_development0.91423539
129MP0008775_abnormal_heart_ventricle0.91237991
130MP0009697_abnormal_copulation0.91229644
131MP0010352_gastrointestinal_tract_polyps0.90938430
132MP0002109_abnormal_limb_morphology0.86992877
133MP0001270_distended_abdomen0.86618704
134MP0003755_abnormal_palate_morphology0.85558194
135MP0003122_maternal_imprinting0.85283242
136MP0002734_abnormal_mechanical_nocicepti0.85091558
137MP0003698_abnormal_male_reproductive0.84810794
138MP0002295_abnormal_pulmonary_circulatio0.83937269
139MP0003937_abnormal_limbs/digits/tail_de0.83639824
140MP0002163_abnormal_gland_morphology0.83597149
141MP0001177_atelectasis0.82362282
142MP0009384_cardiac_valve_regurgitation0.80944845
143MP0003787_abnormal_imprinting0.80874299
144MP0000733_abnormal_muscle_development0.80512800
145MP0000534_abnormal_ureter_morphology0.80482796
146MP0001963_abnormal_hearing_physiology0.77513491
147MP0003959_abnormal_lean_body0.77353634
148MP0002876_abnormal_thyroid_physiology0.77161519
149MP0001299_abnormal_eye_distance/0.76767088
150MP0000613_abnormal_salivary_gland0.75742043
151MP0002115_abnormal_skeleton_extremities0.75586524
152MP0005390_skeleton_phenotype0.74276414
153MP0004272_abnormal_basement_membrane0.73475427
154MP0002572_abnormal_emotion/affect_behav0.73057977
155MP0001243_abnormal_dermal_layer0.72931860
156MP0009046_muscle_twitch0.72594558
157MP0004484_altered_response_of0.72296819
158MP0005551_abnormal_eye_electrophysiolog0.72091422
159MP0001879_abnormal_lymphatic_vessel0.71798887
160MP0002932_abnormal_joint_morphology0.71681958
161MP0002332_abnormal_exercise_endurance0.70890905
162MP0005165_increased_susceptibility_to0.69550202
163MP0002128_abnormal_blood_circulation0.68872639
164MP0005423_abnormal_somatic_nervous0.68387653
165MP0002933_joint_inflammation0.67502550
166MP0004510_myositis0.66399086
167MP0000343_altered_response_to0.62196680
168MP0010630_abnormal_cardiac_muscle0.60309891
169MP0004085_abnormal_heartbeat0.57711320
170MP0009115_abnormal_fat_cell0.57286570
171MP0000428_abnormal_craniofacial_morphol0.55941747
172MP0002127_abnormal_cardiovascular_syste0.52608249
173MP0001614_abnormal_blood_vessel0.50207627
174MP0002133_abnormal_respiratory_system0.49770332

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.52159562
2Type 1 muscle fiber predominance (HP:0003803)6.09332748
3Premature rupture of membranes (HP:0001788)5.28853531
4Absent/shortened dynein arms (HP:0200106)5.21202223
5Dynein arm defect of respiratory motile cilia (HP:0012255)5.21202223
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.95389380
7Aortic aneurysm (HP:0004942)4.94879894
8Abnormal respiratory motile cilium physiology (HP:0012261)4.67876431
9Abnormal ciliary motility (HP:0012262)4.67265668
10Corneal dystrophy (HP:0001131)4.54368025
11Hepatoblastoma (HP:0002884)4.43681602
12Neoplasm of the adrenal cortex (HP:0100641)4.33287584
13Abnormal respiratory motile cilium morphology (HP:0005938)4.15983048
14Abnormal respiratory epithelium morphology (HP:0012253)4.15983048
15Increased variability in muscle fiber diameter (HP:0003557)3.96832653
16Muscle fiber inclusion bodies (HP:0100299)3.87484043
17Nemaline bodies (HP:0003798)3.85867627
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.85786892
19Spinal rigidity (HP:0003306)3.80920071
20Neonatal hypoglycemia (HP:0001998)3.73209349
21Vascular tortuosity (HP:0004948)3.65500884
22Abnormality of skeletal muscle fiber size (HP:0012084)3.64569842
23Aortic dissection (HP:0002647)3.61138063
24Increased connective tissue (HP:0009025)3.60218651
25Slender build (HP:0001533)3.53086331
26Rhinitis (HP:0012384)3.52211855
27Ankle contracture (HP:0006466)3.49341457
28Muscle fiber splitting (HP:0003555)3.48414254
29Round ear (HP:0100830)3.46232530
30Soft skin (HP:0000977)3.45792509
31Follicular hyperkeratosis (HP:0007502)3.25883664
32Lipoatrophy (HP:0100578)3.22708528
33Long foot (HP:0001833)3.18115472
34Abnormality of the calf musculature (HP:0001430)3.14007347
35Broad metatarsal (HP:0001783)3.13698202
36Cervical subluxation (HP:0003308)3.06562066
37Exercise-induced myalgia (HP:0003738)3.04894027
38Asymmetric septal hypertrophy (HP:0001670)3.04590669
39Wormian bones (HP:0002645)3.03632260
40Hyporeflexia of lower limbs (HP:0002600)3.01418207
41Bladder diverticulum (HP:0000015)3.01225422
42Mildly elevated creatine phosphokinase (HP:0008180)2.98203234
43Congenital cataract (HP:0000519)2.97500280
44Shallow orbits (HP:0000586)2.92077596
45Amblyopia (HP:0000646)2.91764832
46Ulnar deviation of the wrist (HP:0003049)2.91576542
47Diastasis recti (HP:0001540)2.90380974
48Congenital primary aphakia (HP:0007707)2.89593264
49Anterior segment dysgenesis (HP:0007700)2.86269948
50Overgrowth (HP:0001548)2.76852951
51Distal lower limb muscle weakness (HP:0009053)2.69076511
52Arterial tortuosity (HP:0005116)2.68309845
53Vertebral compression fractures (HP:0002953)2.67927205
54Abnormal pancreas size (HP:0012094)2.63733371
55Proximal amyotrophy (HP:0007126)2.61884125
56Neck muscle weakness (HP:0000467)2.58642770
57Aplasia/Hypoplasia of the lens (HP:0008063)2.56933176
58Ulnar bowing (HP:0003031)2.52293664
59Abnormality of dentin (HP:0010299)2.52167521
60Ventricular tachycardia (HP:0004756)2.49788753
61Sudden death (HP:0001699)2.49580423
62Dilatation of the ascending aorta (HP:0005111)2.48765387
63Hypoplasia of the iris (HP:0007676)2.45803996
64Renal dysplasia (HP:0000110)2.42916379
65Enlarged kidneys (HP:0000105)2.40666937
66Neonatal short-limb short stature (HP:0008921)2.39146876
67Elbow flexion contracture (HP:0002987)2.38482700
68High anterior hairline (HP:0009890)2.37363689
69Absent eyebrow (HP:0002223)2.35442408
70True hermaphroditism (HP:0010459)2.35062191
71Dilated cardiomyopathy (HP:0001644)2.33435665
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.33345332
73Osteolytic defects of the hand bones (HP:0009699)2.33345332
74Mitral regurgitation (HP:0001653)2.32923797
75Median cleft lip (HP:0000161)2.32379607
76Broad ribs (HP:0000885)2.32190344
77Cerebral aneurysm (HP:0004944)2.30736929
78Blue sclerae (HP:0000592)2.28314108
79Calcaneovalgus deformity (HP:0001848)2.26375024
80Ulnar claw (HP:0001178)2.26139960
81Atrophic scars (HP:0001075)2.25406856
82Distal arthrogryposis (HP:0005684)2.24928626
83Hip contracture (HP:0003273)2.24693800
84Poor coordination (HP:0002370)2.23714814
85Fibular hypoplasia (HP:0003038)2.23172424
86Muscle hypertrophy of the lower extremities (HP:0008968)2.23054729
87EMG: myopathic abnormalities (HP:0003458)2.21971973
88Fragile skin (HP:0001030)2.20915613
89Calf muscle hypertrophy (HP:0008981)2.20587034
90Aortic valve stenosis (HP:0001650)2.19320031
91Septo-optic dysplasia (HP:0100842)2.18433002
92Biconcave vertebral bodies (HP:0004586)2.17701269
93Deformed tarsal bones (HP:0008119)2.17132535
94Limited hip movement (HP:0008800)2.16325637
95Joint stiffness (HP:0001387)2.15925380
96Aneurysm (HP:0002617)2.15263119
97Ovoid vertebral bodies (HP:0003300)2.14854746
98Right ventricular cardiomyopathy (HP:0011663)2.13354763
99Mitral valve prolapse (HP:0001634)2.12700470
100Wide anterior fontanel (HP:0000260)2.12696850
101Bell-shaped thorax (HP:0001591)2.12412347
102Hypoventilation (HP:0002791)2.11598811
103Medial flaring of the eyebrow (HP:0010747)2.11287882
104Alopecia of scalp (HP:0002293)2.11134656
105Abnormality of the acetabulum (HP:0003170)2.08930873
106Morphological abnormality of the middle ear (HP:0008609)2.08543726
107Genu recurvatum (HP:0002816)2.08180497
108Abnormality of the septum pellucidum (HP:0007375)2.07801433
109Exercise-induced muscle cramps (HP:0003710)2.07638042
110Aortic regurgitation (HP:0001659)2.06468429
111Foot dorsiflexor weakness (HP:0009027)2.04499558
112Spondylolisthesis (HP:0003302)2.04360564
113Nuclear cataract (HP:0100018)12.0446718
114Zonular cataract (HP:0010920)11.0658210
115Striae distensae (HP:0001065)1.99458549
116Abnormality of the foot musculature (HP:0001436)1.99455878
117Congenital stationary night blindness (HP:0007642)1.98999025
118Fetal akinesia sequence (HP:0001989)1.96642600
119Atrial fibrillation (HP:0005110)1.96622103
120Tarsal synostosis (HP:0008368)1.96158654
121Abnormality of the renal collecting system (HP:0004742)1.95790421
122Abnormality of the shoulder girdle musculature (HP:0001435)1.95524053
123Bundle branch block (HP:0011710)1.95386752
124Embryonal renal neoplasm (HP:0011794)1.94600823
125Bowel diverticulosis (HP:0005222)1.94341831
126Absent phalangeal crease (HP:0006109)1.92392098
127Wrist flexion contracture (HP:0001239)1.91957993
128Nephrogenic diabetes insipidus (HP:0009806)1.90636936
129Coronal craniosynostosis (HP:0004440)1.90544287
130Limb-girdle muscle atrophy (HP:0003797)1.88052735
131Chronic hepatic failure (HP:0100626)1.87722842
132Nephronophthisis (HP:0000090)1.86166445
133Nephroblastoma (Wilms tumor) (HP:0002667)1.83817192
134Unilateral renal agenesis (HP:0000122)1.83337529
135Vertebral arch anomaly (HP:0008438)1.82432322
136Mild short stature (HP:0003502)1.82022102
137Coxa vara (HP:0002812)1.81715219
138Joint laxity (HP:0001388)1.81379817
139Centrally nucleated skeletal muscle fibers (HP:0003687)1.81221734
140Gait imbalance (HP:0002141)1.81103280
141Chronic bronchitis (HP:0004469)1.80570137
142Advanced eruption of teeth (HP:0006288)1.80269508
143Absent eyelashes (HP:0000561)1.80151827
144Myotonia (HP:0002486)1.80019153
145Abnormality of incisor morphology (HP:0011063)1.79970682
146Hypoplasia of the odontoid process (HP:0003311)1.79294168
147Microcornea (HP:0000482)1.78828126
148Limb-girdle muscle weakness (HP:0003325)1.78720791
149Aplasia/Hypoplasia of the fibula (HP:0006492)1.75330247
150Germ cell neoplasia (HP:0100728)1.73765291
151Abnormality of midbrain morphology (HP:0002418)1.72388178
152Molar tooth sign on MRI (HP:0002419)1.72388178
153Pancreatic fibrosis (HP:0100732)1.71868841
154Narrow nasal bridge (HP:0000446)1.70471147
155Iris coloboma (HP:0000612)1.70008724
156Tracheomalacia (HP:0002779)1.67742570
157Omphalocele (HP:0001539)1.66516748
158Popliteal pterygium (HP:0009756)1.66209136
159Abnormality of molar (HP:0011077)1.66129399
160Abnormality of molar morphology (HP:0011070)1.66129399
161Polar cataract (HP:0010696)1.64358428
162Sclerocornea (HP:0000647)1.63531628
163Aplasia of the musculature (HP:0100854)1.62386088
164Tubulointerstitial nephritis (HP:0001970)1.60942345
165Postaxial foot polydactyly (HP:0001830)1.60599309
166Abnormality of the renal medulla (HP:0100957)1.58164315
167Hyperphosphatemia (HP:0002905)1.56805564
168Deep philtrum (HP:0002002)1.56341922
169Facial cleft (HP:0002006)1.55695170
170Abnormality of the dental pulp (HP:0006479)1.55350036
171Neoplasm of the adrenal gland (HP:0100631)1.55146651
172Congenital hepatic fibrosis (HP:0002612)1.54209616
173Postaxial hand polydactyly (HP:0001162)1.53764239
174Osteomalacia (HP:0002749)1.53611797
175Atelectasis (HP:0100750)1.53601517
176Broad foot (HP:0001769)1.53329746
177Decreased central vision (HP:0007663)1.52837790
178Optic nerve hypoplasia (HP:0000609)1.51470425
179Scapular winging (HP:0003691)1.50573557
180Split foot (HP:0001839)1.50501162
181Submucous cleft hard palate (HP:0000176)1.49802765
182Accelerated skeletal maturation (HP:0005616)1.48323368
183Abnormal glucose tolerance (HP:0001952)1.47177885
184Abnormality of dental color (HP:0011073)1.47069156
185Abnormality of the dental root (HP:0006486)1.46894914
186Taurodontia (HP:0000679)1.46894914
187Abnormality of permanent molar morphology (HP:0011071)1.46894914
188Bronchiectasis (HP:0002110)1.46192329
189Genu varum (HP:0002970)1.45730525
190Short thorax (HP:0010306)1.43593956
191Preaxial hand polydactyly (HP:0001177)1.43548221
192Prostate neoplasm (HP:0100787)1.41592842
193Short femoral neck (HP:0100864)1.41247747
194Occipital encephalocele (HP:0002085)1.41062245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.71224539
2TTN3.69407923
3MKNK23.57948053
4CASK3.21902680
5SIK12.97058368
6NEK92.80254634
7STK162.66778627
8PRKG22.54519025
9CDK82.52329990
10PDGFRA2.46338428
11PIK3CG2.37824475
12ZAK2.36263341
13TGFBR22.19300521
14EPHB22.19097269
15SIK22.11684361
16MAPK152.04732359
17MKNK12.00484084
18NTRK21.90937135
19INSRR1.86602918
20STK38L1.85775893
21ERBB31.83296164
22MAP2K71.78870974
23TNIK1.76026421
24PRKD31.73004816
25EPHA31.72593649
26LMTK21.67522002
27BMPR1B1.53302857
28MAPK131.50900652
29SGK21.50266704
30MAP2K61.42311117
31TRIB31.42151255
32EPHA41.37891322
33MOS1.36774214
34DMPK1.35100189
35PAK21.33790540
36PRPF4B1.26306220
37ADRBK21.25559472
38NEK61.24071262
39SGK4941.18383120
40SGK2231.18383120
41MAPK71.18128572
42LATS11.15332451
43CDK31.15291603
44MAP2K21.15014134
45MARK11.14470526
46FRK1.14232434
47TRPM71.13064070
48LIMK11.11247105
49MAPK121.07107734
50NTRK31.04980303
51PRKAA21.02977766
52PLK21.02427442
53DDR21.01906877
54MAP3K120.99043537
55PDK40.96759628
56PDK30.96759628
57PRKG10.95494354
58PRKD10.95204993
59ADRBK10.94790949
60SGK10.94265820
61PHKG10.93410242
62PHKG20.93410242
63KIT0.92333652
64BMPR20.89257238
65PRKD20.88448319
66TIE10.87803258
67RIPK10.87289622
68PDK20.85992289
69PDGFRB0.85945905
70YES10.85764479
71MELK0.84767143
72PTK20.84326601
73ERN10.83699260
74TAOK20.83402069
75PDPK10.82379196
76IRAK10.81478123
77DAPK30.80993980
78EIF2AK20.79731715
79MAP3K70.79405279
80MAP2K10.79142285
81CAMK2B0.78941135
82MAP3K60.77609176
83PRKCE0.75922646
84TGFBR10.74783806
85PTK2B0.74579636
86STK380.73625976
87KSR20.72247453
88GRK50.71669193
89AKT30.71157272
90MYLK0.71082534
91SGK30.69419372
92SRPK10.68798958
93MAPKAPK30.66648754
94MARK30.64415667
95CAMK2G0.62792066
96TESK10.62508593
97PINK10.62218361
98EEF2K0.61831157
99PRKCG0.60362873
100GRK70.59992541
101CAMK2D0.59706674
102PAK60.59349896
103EPHA20.56050718
104MAP2K30.54930412
105ROCK10.54342689
106ABL20.54045464
107PAK30.53745370
108BCR0.53353671
109MUSK0.53333830
110DYRK1A0.52477786
111MAPK40.51397405
112MAP3K20.50610189
113IRAK20.50502142
114TXK0.50467825
115EPHB10.49906368
116MET0.49043751
117MAP3K30.48942220
118NTRK10.48534874
119RPS6KA20.47783592
120OBSCN0.47726385
121CAMK2A0.47403520
122NEK20.47351483
123CAMK10.46379511
124LATS20.44207802
125CDC42BPA0.43944868
126ROCK20.42471801
127CCNB10.41959455
128ERBB20.41702544
129GRK10.41628444
130GSK3A0.41471843
131DYRK20.41334155
132PAK40.40793408
133FGFR20.39780060
134HIPK20.38634648
135ERBB40.38509940
136MTOR0.37024671
137ICK0.36920562
138WNK10.36711605
139IGF1R0.35352359
140MINK10.34881245
141MAP3K140.33617364
142PIK3CA0.31308724
143PRKACA0.31057920
144AKT10.30456205
145RPS6KL10.29944622
146RPS6KC10.29944622
147JAK10.28772492
148ILK0.27292981
149CAMK40.27156163
150VRK10.26914185
151STK30.26105440
152NLK0.25540738
153MAP3K40.25499744
154PRKAA10.24578539
155AKT20.24478128
156PKN10.23638651
157MAPK30.22828320

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86369815
2Nicotine addiction_Homo sapiens_hsa050332.43907636
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.31397436
4African trypanosomiasis_Homo sapiens_hsa051432.16653179
5Basal cell carcinoma_Homo sapiens_hsa052171.94049104
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86978792
7ECM-receptor interaction_Homo sapiens_hsa045121.74868334
8Axon guidance_Homo sapiens_hsa043601.72530573
9Circadian entrainment_Homo sapiens_hsa047131.71597341
10Wnt signaling pathway_Homo sapiens_hsa043101.61836598
11Steroid hormone biosynthesis_Homo sapiens_hsa001401.60346875
12Phenylalanine metabolism_Homo sapiens_hsa003601.59683005
13Circadian rhythm_Homo sapiens_hsa047101.59316094
14Serotonergic synapse_Homo sapiens_hsa047261.55981786
15Taste transduction_Homo sapiens_hsa047421.55788093
16Insulin secretion_Homo sapiens_hsa049111.52496425
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48767777
18Rheumatoid arthritis_Homo sapiens_hsa053231.47855790
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44550717
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38873052
21Cardiac muscle contraction_Homo sapiens_hsa042601.37656025
22Hedgehog signaling pathway_Homo sapiens_hsa043401.36163939
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30080647
24Renin secretion_Homo sapiens_hsa049241.29540930
25Olfactory transduction_Homo sapiens_hsa047401.29361133
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29145794
27Calcium signaling pathway_Homo sapiens_hsa040201.27164834
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26867986
29Proteoglycans in cancer_Homo sapiens_hsa052051.22153357
30Morphine addiction_Homo sapiens_hsa050321.22075864
31Glutamatergic synapse_Homo sapiens_hsa047241.21586659
32Melanogenesis_Homo sapiens_hsa049161.18520933
33Malaria_Homo sapiens_hsa051441.16740056
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.13115813
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12652836
36Phagosome_Homo sapiens_hsa041451.12450394
37PPAR signaling pathway_Homo sapiens_hsa033201.11987221
38Autoimmune thyroid disease_Homo sapiens_hsa053201.11814823
39Synaptic vesicle cycle_Homo sapiens_hsa047211.11780291
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11503655
41Adherens junction_Homo sapiens_hsa045201.10773056
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10536532
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06318405
44Gastric acid secretion_Homo sapiens_hsa049711.05877168
45Protein digestion and absorption_Homo sapiens_hsa049741.02914802
46Salivary secretion_Homo sapiens_hsa049701.02656084
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99940480
48Dorso-ventral axis formation_Homo sapiens_hsa043200.99474725
49Hippo signaling pathway_Homo sapiens_hsa043900.98153440
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97543213
51Cocaine addiction_Homo sapiens_hsa050300.96148293
52Cholinergic synapse_Homo sapiens_hsa047250.96144761
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93725094
54Tyrosine metabolism_Homo sapiens_hsa003500.93605605
55Amphetamine addiction_Homo sapiens_hsa050310.92907996
56Long-term depression_Homo sapiens_hsa047300.92701341
57Dilated cardiomyopathy_Homo sapiens_hsa054140.92675976
58Mineral absorption_Homo sapiens_hsa049780.92612802
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91415927
60GABAergic synapse_Homo sapiens_hsa047270.90638251
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90010645
62Collecting duct acid secretion_Homo sapiens_hsa049660.89809434
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87386743
64Histidine metabolism_Homo sapiens_hsa003400.86990315
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.83120778
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.83106373
67Melanoma_Homo sapiens_hsa052180.81729706
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80224057
69Phototransduction_Homo sapiens_hsa047440.80099933
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79713233
71Ovarian steroidogenesis_Homo sapiens_hsa049130.79650446
72Fatty acid degradation_Homo sapiens_hsa000710.79148221
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78020088
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77920352
75Amoebiasis_Homo sapiens_hsa051460.76474760
76Estrogen signaling pathway_Homo sapiens_hsa049150.75611650
77cAMP signaling pathway_Homo sapiens_hsa040240.75189440
78Notch signaling pathway_Homo sapiens_hsa043300.73557053
79ABC transporters_Homo sapiens_hsa020100.72732815
80Gap junction_Homo sapiens_hsa045400.72500843
81Thyroid hormone synthesis_Homo sapiens_hsa049180.72344149
82Graft-versus-host disease_Homo sapiens_hsa053320.72152688
83AMPK signaling pathway_Homo sapiens_hsa041520.71745797
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69751524
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69724136
86Fanconi anemia pathway_Homo sapiens_hsa034600.67894635
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67278737
88Tight junction_Homo sapiens_hsa045300.67248924
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.66768621
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66066086
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65688683
92Focal adhesion_Homo sapiens_hsa045100.65287091
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65254884
94Pyruvate metabolism_Homo sapiens_hsa006200.65112544
95Arachidonic acid metabolism_Homo sapiens_hsa005900.64816418
96Dopaminergic synapse_Homo sapiens_hsa047280.64525197
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64411684
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64322561
99Small cell lung cancer_Homo sapiens_hsa052220.64295192
100Glucagon signaling pathway_Homo sapiens_hsa049220.64102200
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63904111
102Chemical carcinogenesis_Homo sapiens_hsa052040.62491560
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62349223
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61445934
105Long-term potentiation_Homo sapiens_hsa047200.61239692
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61079476
107Type II diabetes mellitus_Homo sapiens_hsa049300.59306036
108Bile secretion_Homo sapiens_hsa049760.58339309
109Renin-angiotensin system_Homo sapiens_hsa046140.58296908
110Insulin signaling pathway_Homo sapiens_hsa049100.58187829
111Nitrogen metabolism_Homo sapiens_hsa009100.57657493
112Complement and coagulation cascades_Homo sapiens_hsa046100.57141492
113TNF signaling pathway_Homo sapiens_hsa046680.56551218
114Insulin resistance_Homo sapiens_hsa049310.56430287
115Rap1 signaling pathway_Homo sapiens_hsa040150.55424656
116Oxytocin signaling pathway_Homo sapiens_hsa049210.55375222
117Lysine degradation_Homo sapiens_hsa003100.55303462
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55107720
119Pathways in cancer_Homo sapiens_hsa052000.54465553
120Tryptophan metabolism_Homo sapiens_hsa003800.54336670
121Sphingolipid metabolism_Homo sapiens_hsa006000.54074297
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53476879
123Viral myocarditis_Homo sapiens_hsa054160.53291301
124TGF-beta signaling pathway_Homo sapiens_hsa043500.53116447
125GnRH signaling pathway_Homo sapiens_hsa049120.52287382
126Platelet activation_Homo sapiens_hsa046110.50920409
127VEGF signaling pathway_Homo sapiens_hsa043700.50459806
128beta-Alanine metabolism_Homo sapiens_hsa004100.50250429
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.50153403
130Prostate cancer_Homo sapiens_hsa052150.49723478
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48876253
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.48426318
133Vibrio cholerae infection_Homo sapiens_hsa051100.48346387
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47875775
135Asthma_Homo sapiens_hsa053100.47719823
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47667523
137MicroRNAs in cancer_Homo sapiens_hsa052060.46590793
138Glioma_Homo sapiens_hsa052140.42740551
139Pancreatic secretion_Homo sapiens_hsa049720.39366716
140Glycerolipid metabolism_Homo sapiens_hsa005610.36268569
141Ras signaling pathway_Homo sapiens_hsa040140.34397804
142Arginine and proline metabolism_Homo sapiens_hsa003300.33210127
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.32553488
144Prion diseases_Homo sapiens_hsa050200.31724850

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