VIMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)6.71697348
2central nervous system myelination (GO:0022010)6.61866246
3axon ensheathment in central nervous system (GO:0032291)6.61866246
4fatty acid elongation (GO:0030497)5.66954657
5cholesterol biosynthetic process (GO:0006695)4.67372419
6pyrimidine-containing compound transmembrane transport (GO:0072531)4.60722457
7nucleotide transmembrane transport (GO:1901679)4.34865466
8sterol biosynthetic process (GO:0016126)4.10187225
9eosinophil chemotaxis (GO:0048245)3.92599682
10long-chain fatty acid biosynthetic process (GO:0042759)3.89875401
11isoprenoid biosynthetic process (GO:0008299)3.72479720
12Golgi transport vesicle coating (GO:0048200)3.66196122
13COPI coating of Golgi vesicle (GO:0048205)3.66196122
14myelination (GO:0042552)3.61382586
15ensheathment of neurons (GO:0007272)3.60708794
16axon ensheathment (GO:0008366)3.60708794
17COPII vesicle coating (GO:0048208)3.53449256
18regulation of cellular amino acid metabolic process (GO:0006521)3.49056198
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.46476064
20magnesium ion transport (GO:0015693)3.45200311
21eosinophil migration (GO:0072677)3.43311827
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37000950
23photoreceptor cell differentiation (GO:0046530)3.33693012
24eye photoreceptor cell differentiation (GO:0001754)3.33693012
25sphingosine metabolic process (GO:0006670)3.31501509
26protein neddylation (GO:0045116)3.31379987
27positive regulation of cellular amine metabolic process (GO:0033240)3.31347915
28mannosylation (GO:0097502)3.27347872
29nucleotide-sugar biosynthetic process (GO:0009226)3.26554033
30protein maturation by protein folding (GO:0022417)3.24874057
31dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.24791655
32amyloid precursor protein catabolic process (GO:0042987)3.22433830
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21984289
34* response to redox state (GO:0051775)3.21574166
35GDP-mannose metabolic process (GO:0019673)3.19068846
36amyloid precursor protein metabolic process (GO:0042982)3.15937098
37glycolipid catabolic process (GO:0019377)3.15072687
38GPI anchor biosynthetic process (GO:0006506)3.14555843
39peptidyl-histidine modification (GO:0018202)3.12421988
40protein retention in ER lumen (GO:0006621)3.10400954
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10179761
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08822355
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08723069
44L-phenylalanine catabolic process (GO:0006559)3.08723069
45regulation of cytokine secretion involved in immune response (GO:0002739)3.07112868
46cellular response to zinc ion (GO:0071294)3.04331739
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.02949884
48termination of RNA polymerase III transcription (GO:0006386)3.02949884
49diol metabolic process (GO:0034311)3.02715297
50positive regulation of prostaglandin secretion (GO:0032308)3.01850503
51regulation of vitamin metabolic process (GO:0030656)3.01688398
52oligodendrocyte differentiation (GO:0048709)3.01391928
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99063779
54sphingomyelin metabolic process (GO:0006684)2.98747587
55sphingoid metabolic process (GO:0046519)2.97876329
56regulation of chronic inflammatory response (GO:0002676)2.97187710
57nucleotide transport (GO:0006862)2.96218371
58regulation of mononuclear cell migration (GO:0071675)2.95887911
59ceramide catabolic process (GO:0046514)2.95553713
60L-methionine salvage (GO:0071267)2.95023096
61L-methionine biosynthetic process (GO:0071265)2.95023096
62amino acid salvage (GO:0043102)2.95023096
63protein deneddylation (GO:0000338)2.94560137
64long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.93276502
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.91413334
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90961520
67negative regulation of ligase activity (GO:0051352)2.90961520
68glycosylceramide metabolic process (GO:0006677)2.90044199
69GPI anchor metabolic process (GO:0006505)2.89499251
70proteasome assembly (GO:0043248)2.87360586
71regulation of vitamin D biosynthetic process (GO:0060556)2.87200524
72water-soluble vitamin biosynthetic process (GO:0042364)2.83643127
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83556193
74nucleoside diphosphate catabolic process (GO:0009134)2.82944300
75* ER overload response (GO:0006983)2.82926672
76glycosphingolipid catabolic process (GO:0046479)2.81963842
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80685844
78endocrine pancreas development (GO:0031018)2.80401590
79negative regulation of neurotransmitter secretion (GO:0046929)2.75550689
80regulation of immunoglobulin secretion (GO:0051023)2.75376599
81intracellular pH reduction (GO:0051452)2.74575350
82glycerophospholipid catabolic process (GO:0046475)2.72965037
83sequestering of metal ion (GO:0051238)2.72929741
84regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.72918659
85antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.72244255
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71069937
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71069937
88cytidine metabolic process (GO:0046087)2.69237972
89cytidine catabolic process (GO:0006216)2.69237972
90cytidine deamination (GO:0009972)2.69237972
91DNA deamination (GO:0045006)2.68504851
92activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.68387629
93regulation of metalloenzyme activity (GO:0048552)2.68358569
94cullin deneddylation (GO:0010388)2.68303245
95negative regulation of chemokine production (GO:0032682)2.68220072
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67880080
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67880080
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67880080
99protein complex biogenesis (GO:0070271)2.67431077
100peptide hormone processing (GO:0016486)2.64994744
101adhesion of symbiont to host cell (GO:0044650)2.63876242
102virion attachment to host cell (GO:0019062)2.63876242
103UDP-N-acetylglucosamine metabolic process (GO:0006047)2.63706201
104nucleotide-sugar metabolic process (GO:0009225)2.63445817
105regulation of prostaglandin secretion (GO:0032306)2.61608553
106pH reduction (GO:0045851)2.61467387
107* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.61048997
108positive regulation of monocyte chemotaxis (GO:0090026)2.60341327
109respiratory chain complex IV assembly (GO:0008535)2.59221562
110myelin maintenance (GO:0043217)2.56393407
111fatty-acyl-CoA biosynthetic process (GO:0046949)2.56026167
112establishment of protein localization to mitochondrial membrane (GO:0090151)2.55937113
113cytochrome complex assembly (GO:0017004)2.55918363
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.54801499
115response to methylmercury (GO:0051597)2.54761486
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.54547058
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.54547058
118platelet dense granule organization (GO:0060155)2.54346474
119long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.54287381
120mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53870343
121preassembly of GPI anchor in ER membrane (GO:0016254)2.53639516
122ATP synthesis coupled proton transport (GO:0015986)2.53460205
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53460205
124chaperone-mediated protein transport (GO:0072321)2.53320404
125* cell redox homeostasis (GO:0045454)2.53317255
126mitochondrial respiratory chain complex assembly (GO:0033108)2.53215671
127regulation of mitochondrial translation (GO:0070129)2.51737424
128cofactor transport (GO:0051181)2.51539376
129carbohydrate derivative transport (GO:1901264)2.51468028
130protein targeting to mitochondrion (GO:0006626)2.51317386
131L-phenylalanine metabolic process (GO:0006558)2.51135798
132erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.51135798
133histone H2B ubiquitination (GO:0033523)2.50884491
134positive regulation of ligase activity (GO:0051351)2.50430451
135anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.50279820
136glandular epithelial cell differentiation (GO:0002067)2.50032517
137substantia nigra development (GO:0021762)2.49532698
138regulation of lipoprotein metabolic process (GO:0050746)2.48764960
139phosphatidylserine acyl-chain remodeling (GO:0036150)2.48590735
140regulation of cellular amine metabolic process (GO:0033238)2.47784927
141phosphatidylserine metabolic process (GO:0006658)2.47121140
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.46926693
143vitamin biosynthetic process (GO:0009110)2.46452557
144regulation of collateral sprouting (GO:0048670)2.46216192
145creatine metabolic process (GO:0006600)2.46105358
146ribosome assembly (GO:0042255)2.45970547
147very long-chain fatty acid metabolic process (GO:0000038)2.45195348
148intestinal cholesterol absorption (GO:0030299)2.44535751
149respiratory electron transport chain (GO:0022904)2.44498750
150ER to Golgi vesicle-mediated transport (GO:0006888)2.41950030
151fatty-acyl-CoA metabolic process (GO:0035337)2.41489662
152monocyte chemotaxis (GO:0002548)2.41019710
153electron transport chain (GO:0022900)2.40990246
154GTP biosynthetic process (GO:0006183)2.40757715
155keratan sulfate catabolic process (GO:0042340)2.40241597
156alcohol biosynthetic process (GO:0046165)2.38870889
157regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38554043
158negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.36032555
159regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.35617576
160regulation of podosome assembly (GO:0071801)2.34257707
161membrane budding (GO:0006900)2.33193718
1624-hydroxyproline metabolic process (GO:0019471)2.27673851
163establishment of protein localization to mitochondrion (GO:0072655)2.27135342
164macrophage chemotaxis (GO:0048246)2.23672172
165protein localization to mitochondrion (GO:0070585)2.23211654
166positive regulation of cell cycle arrest (GO:0071158)2.21879413
167fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.21780268
168regulation of apoptotic process involved in morphogenesis (GO:1902337)2.21441537
169regulation of ubiquitin-protein transferase activity (GO:0051438)2.18347140
170mitochondrial respiratory chain complex I assembly (GO:0032981)2.18345462
171NADH dehydrogenase complex assembly (GO:0010257)2.18345462
172mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.18345462
173quinone metabolic process (GO:1901661)2.18090668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.27895897
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.82986433
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81301474
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.43889933
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19580711
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14659090
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.11082647
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.04593807
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72773092
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.68092097
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58381538
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.27090558
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.20635737
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17659862
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.13044394
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12468094
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09780364
18VDR_22108803_ChIP-Seq_LS180_Human2.09461792
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.07446064
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96818695
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.95911960
22ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.92955106
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88841908
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.86394323
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86350326
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85882015
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83626500
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83331160
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.80387886
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80077846
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.76197026
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74760233
33GABP_19822575_ChIP-Seq_HepG2_Human1.72946762
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70403995
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66465646
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65113551
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64826500
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64561726
39TFEB_21752829_ChIP-Seq_HELA_Human1.64324695
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63099220
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60507485
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52839400
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.49930252
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48538786
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48200610
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47974080
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43702031
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41438217
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.41197351
50FOXP3_21729870_ChIP-Seq_TREG_Human1.39684312
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.38350283
52HTT_18923047_ChIP-ChIP_STHdh_Human1.35983933
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35356639
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34693900
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31714325
56ELK1_19687146_ChIP-ChIP_HELA_Human1.30485602
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.29003610
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28785139
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.27633208
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27162567
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25782081
62ELF5_23300383_ChIP-Seq_T47D_Human1.25468683
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24081794
64VDR_23849224_ChIP-Seq_CD4+_Human1.24049252
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.22485336
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20147742
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20147742
68ER_23166858_ChIP-Seq_MCF-7_Human1.19543132
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16519303
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16501743
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16501743
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13944805
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.13841525
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13232678
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12666773
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12461888
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12339702
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.12125395
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11670797
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09740904
81PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08864892
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08595334
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07921167
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07473383
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07270969
86ZNF263_19887448_ChIP-Seq_K562_Human1.06880620
87SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06784345
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06642759
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06299505
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05772295
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05643972
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.05203271
93GATA4_25053715_ChIP-Seq_YYC3_Human1.04770242
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04763103
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03403427
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.03153953
97RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02212869
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00931361
99TTF2_22483619_ChIP-Seq_HELA_Human1.00448063
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00432940
101CLOCK_20551151_ChIP-Seq_293T_Human0.99982090
102SOX2_20726797_ChIP-Seq_SW620_Human0.99819015
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99534163
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.99356317
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99323757
106ATF3_27146783_Chip-Seq_COLON_Human0.98867703
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98749891
108KLF4_18555785_Chip-Seq_ESCs_Mouse0.98482298
109IRF1_19129219_ChIP-ChIP_H3396_Human0.97677044
110NFE2_27457419_Chip-Seq_LIVER_Mouse0.97395651
111THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97283731
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97161111
113NMYC_18555785_Chip-Seq_ESCs_Mouse0.96911836
114SOX2_18555785_Chip-Seq_ESCs_Mouse0.96767259
115AR_21909140_ChIP-Seq_LNCAP_Human0.96625548
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94823540
117GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94532850
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94263248
119SOX2_19829295_ChIP-Seq_ESCs_Human0.94148103
120NANOG_19829295_ChIP-Seq_ESCs_Human0.94148103
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94118218
122CJUN_26792858_Chip-Seq_BT549_Human0.94101878
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94016680
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93544361
125ZFX_18555785_Chip-Seq_ESCs_Mouse0.92436252
126DCP1A_22483619_ChIP-Seq_HELA_Human0.92274186
127MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92260598
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92070989
129P53_22387025_ChIP-Seq_ESCs_Mouse0.91970225
130P300_18555785_Chip-Seq_ESCs_Mouse0.91946588
131CMYC_18555785_Chip-Seq_ESCs_Mouse0.91905138
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91900908
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90978327
134ERG_20517297_ChIP-Seq_VCAP_Human0.90530868
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.90355806
136ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89753659
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89525257
138EOMES_21245162_ChIP-Seq_HESCs_Human0.89523261
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89154114
140IRF8_21731497_ChIP-ChIP_J774_Mouse0.88978730
141BRD4_25478319_ChIP-Seq_HGPS_Human0.87986045
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87599991
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.85841279
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85515259
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85440929
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84798936
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84189270
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84109618
149PHF8_20622853_ChIP-Seq_HELA_Human0.84019306
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83962502
151LXR_22158963_ChIP-Seq_LIVER_Mouse0.83391329
152GATA6_25053715_ChIP-Seq_YYC3_Human0.82821304
153ESR1_21235772_ChIP-Seq_MCF-7_Human0.82753245
154MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82607544
155PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82348603
156PU1_27457419_Chip-Seq_LIVER_Mouse0.81497785
157GATA6_21074721_ChIP-Seq_CACO-2_Human0.81337207
158SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80684940
159KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80429623
160KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80429623
161KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80429623
162AR_20517297_ChIP-Seq_VCAP_Human0.80189430
163FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80099053
164NCOR_22424771_ChIP-Seq_293T_Human0.79992938
165STAT1_17558387_ChIP-Seq_HELA_Human0.79008910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.50220316
2MP0004043_abnormal_pH_regulation3.34852632
3MP0000920_abnormal_myelination3.34239551
4MP0005058_abnormal_lysosome_morphology3.29635044
5MP0003136_yellow_coat_color2.99021711
6MP0003806_abnormal_nucleotide_metabolis2.91935285
7MP0005451_abnormal_body_composition2.63040642
8MP0005360_urolithiasis2.55627410
9MP0005083_abnormal_biliary_tract2.50203754
10MP0009785_altered_susceptibility_to2.41456764
11MP0005408_hypopigmentation2.41112405
12MP0004272_abnormal_basement_membrane2.35933086
13MP0005379_endocrine/exocrine_gland_phen2.30486352
14MP0006054_spinal_hemorrhage2.29872856
15MP0002139_abnormal_hepatobiliary_system2.29485646
16MP0001661_extended_life_span2.20379167
17MP0003186_abnormal_redox_activity2.16155496
18MP0001542_abnormal_bone_strength2.16032567
19MP0008260_abnormal_autophagy2.15717799
20MP0001905_abnormal_dopamine_level2.08868480
21MP0010234_abnormal_vibrissa_follicle2.07851116
22MP0005220_abnormal_exocrine_pancreas2.07292450
23MP0001853_heart_inflammation1.99216023
24MP0002295_abnormal_pulmonary_circulatio1.96846612
25MP0005365_abnormal_bile_salt1.96408602
26MP0001666_abnormal_nutrient_absorption1.93054233
27MP0005410_abnormal_fertilization1.90341459
28MP0008438_abnormal_cutaneous_collagen1.89346372
29MP0001529_abnormal_vocalization1.87697108
30MP0003718_maternal_effect1.82629203
31MP0005171_absent_coat_pigmentation1.82414520
32MP0002254_reproductive_system_inflammat1.81320611
33MP0000343_altered_response_to1.78464519
34MP0003183_abnormal_peptide_metabolism1.77638103
35MP0003690_abnormal_glial_cell1.76305422
36MP0004134_abnormal_chest_morphology1.70232064
37MP0010386_abnormal_urinary_bladder1.65833449
38MP0000462_abnormal_digestive_system1.63687898
39MP0005084_abnormal_gallbladder_morpholo1.62462508
40MP0003191_abnormal_cellular_cholesterol1.61308902
41MP0004381_abnormal_hair_follicle1.61279374
42MP0003941_abnormal_skin_development1.58402122
43MP0006082_CNS_inflammation1.58089693
44MP0002693_abnormal_pancreas_physiology1.57788217
45MP0000372_irregular_coat_pigmentation1.52531265
46MP0008875_abnormal_xenobiotic_pharmacok1.52316406
47MP0001984_abnormal_olfaction1.49801875
48MP0003950_abnormal_plasma_membrane1.49645148
49MP0005165_increased_susceptibility_to1.48054463
50MP0002877_abnormal_melanocyte_morpholog1.45471048
51MP0005275_abnormal_skin_tensile1.44175257
52MP0001485_abnormal_pinna_reflex1.43745949
53MP0005332_abnormal_amino_acid1.43140504
54MP0002933_joint_inflammation1.42822303
55MP0009840_abnormal_foam_cell1.42467872
56MP0002163_abnormal_gland_morphology1.42424480
57MP0004742_abnormal_vestibular_system1.40391054
58MP0002060_abnormal_skin_morphology1.38981183
59MP0005023_abnormal_wound_healing1.38030364
60MP0003724_increased_susceptibility_to1.36743805
61MP0002938_white_spotting1.36545912
62MP0002638_abnormal_pupillary_reflex1.36333256
63MP0003634_abnormal_glial_cell1.35216465
64MP0009384_cardiac_valve_regurgitation1.34736909
65MP0004019_abnormal_vitamin_homeostasis1.33473785
66MP0003329_amyloid_beta_deposits1.32692954
67MP0002138_abnormal_hepatobiliary_system1.32103264
68MP0001944_abnormal_pancreas_morphology1.29996187
69MP0005636_abnormal_mineral_homeostasis1.29232540
70MP0005166_decreased_susceptibility_to1.28965472
71MP0001881_abnormal_mammary_gland1.28592003
72MP0005671_abnormal_response_to1.28086917
73MP0003436_decreased_susceptibility_to1.27119099
74MP0001243_abnormal_dermal_layer1.25685365
75MP0010155_abnormal_intestine_physiology1.24070020
76MP0001835_abnormal_antigen_presentation1.19940627
77MP0003786_premature_aging1.19837838
78MP0003448_altered_tumor_morphology1.19271538
79MP0001845_abnormal_inflammatory_respons1.18699989
80MP0006036_abnormal_mitochondrial_physio1.17811139
81MP0005310_abnormal_salivary_gland1.16792192
82MP0001986_abnormal_taste_sensitivity1.16568584
83MP0000613_abnormal_salivary_gland1.15394885
84MP0001764_abnormal_homeostasis1.14511496
85MP0000015_abnormal_ear_pigmentation1.12277213
86MP0003693_abnormal_embryo_hatching1.10710795
87MP0009643_abnormal_urine_homeostasis1.10451914
88MP0002796_impaired_skin_barrier1.08774798
89MP0004782_abnormal_surfactant_physiolog1.08178690
90MP0001533_abnormal_skeleton_physiology1.07275629
91MP0002837_dystrophic_cardiac_calcinosis1.06857211
92MP0003279_aneurysm1.06543537
93MP0009697_abnormal_copulation1.05425642
94MP0000647_abnormal_sebaceous_gland1.04661265
95MP0002118_abnormal_lipid_homeostasis1.04432930
96MP0005670_abnormal_white_adipose1.03737275
97MP0009764_decreased_sensitivity_to1.02420230
98MP0005387_immune_system_phenotype0.99796250
99MP0001790_abnormal_immune_system0.99796250
100MP0005085_abnormal_gallbladder_physiolo0.97727292
101MP0003868_abnormal_feces_composition0.97520004
102MP0002876_abnormal_thyroid_physiology0.96621805
103MP0005395_other_phenotype0.96613771
104MP0000685_abnormal_immune_system0.95036562
105MP0005025_abnormal_response_to0.94316918
106MP0005164_abnormal_response_to0.94002952
107MP0001851_eye_inflammation0.93780501
108MP0002148_abnormal_hypersensitivity_rea0.93294008
109MP0004264_abnormal_extraembryonic_tissu0.91832048
110MP0005390_skeleton_phenotype0.89798649
111MP0002229_neurodegeneration0.89256527
112MP0001216_abnormal_epidermal_layer0.88647561
113MP0000013_abnormal_adipose_tissue0.88423929
114MP0000858_altered_metastatic_potential0.88343498
115MP0003795_abnormal_bone_structure0.88203719
116MP0000604_amyloidosis0.87752384
117MP0004885_abnormal_endolymph0.87610541
118MP0005508_abnormal_skeleton_morphology0.87325845
119MP0009763_increased_sensitivity_to0.87117322
120MP0001727_abnormal_embryo_implantation0.87034841
121MP0000538_abnormal_urinary_bladder0.85948295
122MP0000627_abnormal_mammary_gland0.85805263
123MP0002277_abnormal_respiratory_mucosa0.85798426
124MP0000163_abnormal_cartilage_morphology0.85473339
125MP0003075_altered_response_to0.84365832
126MP0003011_delayed_dark_adaptation0.84200643
127MP0005319_abnormal_enzyme/_coenzyme0.83857225
128MP0005330_cardiomyopathy0.83225187
129MP0008873_increased_physiological_sensi0.82458634
130MP0005197_abnormal_uvea_morphology0.82249995
131MP0008007_abnormal_cellular_replicative0.82102164
132MP0008004_abnormal_stomach_pH0.81849519
133MP0005501_abnormal_skin_physiology0.81799955
134MP0004957_abnormal_blastocyst_morpholog0.81569459
135MP0001963_abnormal_hearing_physiology0.81558151
136MP0002419_abnormal_innate_immunity0.80599900
137MP0001299_abnormal_eye_distance/0.79894110
138MP0009333_abnormal_splenocyte_physiolog0.79832512
139MP0005503_abnormal_tendon_morphology0.79668593
140MP0009780_abnormal_chondrocyte_physiolo0.76457083
141MP0000566_synostosis0.76259808
142MP0004947_skin_inflammation0.74918148
143MP0003453_abnormal_keratinocyte_physiol0.74171919
144MP0002136_abnormal_kidney_physiology0.73829271
145MP0004142_abnormal_muscle_tone0.73548186
146MP0003300_gastrointestinal_ulcer0.72327999
147MP0009250_abnormal_appendicular_skeleto0.71176439
148MP0008469_abnormal_protein_level0.70804135
149MP0001765_abnormal_ion_homeostasis0.70394788
150MP0002132_abnormal_respiratory_system0.70036038
151MP0002723_abnormal_immune_serum0.69813856
152MP0000762_abnormal_tongue_morphology0.69124448
153MP0003656_abnormal_erythrocyte_physiolo0.68604220
154MP0005551_abnormal_eye_electrophysiolog0.68115831
155MP0005000_abnormal_immune_tolerance0.66287911
156MP0000230_abnormal_systemic_arterial0.65971780
157MP0005257_abnormal_intraocular_pressure0.64951846
158MP0006072_abnormal_retinal_apoptosis0.63424254
159MP0000383_abnormal_hair_follicle0.62361280

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)3.82992879
2Epiphyseal dysplasia (HP:0002656)3.64035739
3Small epiphyses (HP:0010585)3.58559769
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.47859801
5Parakeratosis (HP:0001036)3.29991866
6Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23527209
7Neurofibrillary tangles (HP:0002185)3.10647775
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02434372
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02434372
10Abnormality of proline metabolism (HP:0010907)3.00559647
11Hydroxyprolinuria (HP:0003080)3.00559647
12Cerebral edema (HP:0002181)2.94813020
13Abnormal tarsal ossification (HP:0008369)2.94091919
14Flat capital femoral epiphysis (HP:0003370)2.89608721
15Vacuolated lymphocytes (HP:0001922)2.85608735
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81135464
17Congenital ichthyosiform erythroderma (HP:0007431)2.79909841
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75917320
19Abnormal protein N-linked glycosylation (HP:0012347)2.75917320
20Abnormal protein glycosylation (HP:0012346)2.75917320
21Abnormal glycosylation (HP:0012345)2.75917320
22Beaking of vertebral bodies (HP:0004568)2.74539103
23Sparse eyelashes (HP:0000653)2.74465668
24Acute necrotizing encephalopathy (HP:0006965)2.73153752
25Type I transferrin isoform profile (HP:0003642)2.72240435
26Premature rupture of membranes (HP:0001788)2.71565364
27Delayed epiphyseal ossification (HP:0002663)2.65462015
28Dysostosis multiplex (HP:0000943)2.65395550
29Renal Fanconi syndrome (HP:0001994)2.65190767
30Irregular vertebral endplates (HP:0003301)2.62397868
31Nausea (HP:0002018)2.61444508
32Vertebral compression fractures (HP:0002953)2.57034199
33Abnormality of the intrinsic pathway (HP:0010989)2.54841371
34Cerebral hypomyelination (HP:0006808)2.53845100
35Reduced antithrombin III activity (HP:0001976)2.53095189
36Abnormality of the vertebral endplates (HP:0005106)2.47847124
37Acute encephalopathy (HP:0006846)2.43780349
38Follicular hyperkeratosis (HP:0007502)2.41971033
39Microretrognathia (HP:0000308)2.41556925
40Oral leukoplakia (HP:0002745)2.40747082
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38476004
42Protuberant abdomen (HP:0001538)2.37587470
43Autoamputation (HP:0001218)2.36958927
44Lipid accumulation in hepatocytes (HP:0006561)2.32768499
45Prolonged neonatal jaundice (HP:0006579)2.32664733
46Barrel-shaped chest (HP:0001552)2.30655628
47Cutaneous melanoma (HP:0012056)2.30543681
48Hypoplastic pelvis (HP:0008839)2.30123185
49Adrenal hypoplasia (HP:0000835)2.29869777
50Lactic acidosis (HP:0003128)2.28757177
51Abnormality of the lumbar spine (HP:0100712)2.28712321
52Progressive neurologic deterioration (HP:0002344)2.27942722
53Rough bone trabeculation (HP:0100670)2.27920748
54Retinal dysplasia (HP:0007973)2.24741063
55Mitochondrial inheritance (HP:0001427)2.24609672
56Increased intramyocellular lipid droplets (HP:0012240)2.23575000
57Systemic lupus erythematosus (HP:0002725)2.23116073
58Abnormal mitochondria in muscle tissue (HP:0008316)2.23085955
59Abnormality of the anterior horn cell (HP:0006802)2.18878496
60Degeneration of anterior horn cells (HP:0002398)2.18878496
61Metaphyseal dysplasia (HP:0100255)2.17828624
62Respiratory failure (HP:0002878)2.16688691
63Malnutrition (HP:0004395)2.16391980
64Lethargy (HP:0001254)2.15760731
65Patchy hypopigmentation of hair (HP:0011365)2.15301735
66Dicarboxylic aciduria (HP:0003215)2.15179173
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15179173
68Increased serum lactate (HP:0002151)2.14520303
69Prolonged partial thromboplastin time (HP:0003645)2.14409070
703-Methylglutaconic aciduria (HP:0003535)2.14144302
71Abnormality of the femoral head (HP:0003368)2.13127305
72Disproportionate short-trunk short stature (HP:0003521)2.13096164
73Abnormality of glycolysis (HP:0004366)2.12683391
74Increased serum pyruvate (HP:0003542)2.12683391
75Steatorrhea (HP:0002570)2.10792953
76Metaphyseal irregularity (HP:0003025)2.10356498
77Genu varum (HP:0002970)2.09435189
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09431578
79Abnormality of renal resorption (HP:0011038)2.09327990
80Degeneration of the lateral corticospinal tracts (HP:0002314)2.08774460
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08774460
82Hypoplasia of the odontoid process (HP:0003311)2.07676223
83Methylmalonic aciduria (HP:0012120)2.06351421
84Spastic paraparesis (HP:0002313)2.06234589
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.05502114
86Absent epiphyses (HP:0010577)2.05502114
87Abnormality of the phalanges of the 2nd finger (HP:0009541)2.05420815
88Progressive macrocephaly (HP:0004481)2.05309720
89Intrahepatic cholestasis (HP:0001406)2.03263829
90Aplasia/hypoplasia of the uterus (HP:0008684)2.02477486
91Hepatosplenomegaly (HP:0001433)2.01472033
92Albinism (HP:0001022)2.00000365
93Abnormal trabecular bone morphology (HP:0100671)1.99515069
94Dry hair (HP:0011359)1.99130782
95Exercise intolerance (HP:0003546)1.98710045
96Increased muscle lipid content (HP:0009058)1.98071939
97Abnormal foot bone ossification (HP:0010675)1.97076294
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97064935
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95850788
100Hypokinesia (HP:0002375)1.95689542
101Chronic diarrhea (HP:0002028)1.94955799
102Abnormality of monocarboxylic acid metabolism (HP:0010996)1.93830983
103Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.93542382
104Abnormality of femoral epiphyses (HP:0006499)1.93542382
105CNS demyelination (HP:0007305)1.93225639
106Amniotic constriction ring (HP:0009775)1.92381169
107Abnormality of placental membranes (HP:0011409)1.92381169
108Abnormality of the epiphysis of the femoral head (HP:0010574)1.92247963
109Palpitations (HP:0001962)1.91423661
110Abnormal epiphyseal ossification (HP:0010656)1.91197486
111Generalized aminoaciduria (HP:0002909)1.90430512
112Symptomatic seizures (HP:0011145)1.90222956
113Hepatic necrosis (HP:0002605)1.90212050
114Split foot (HP:0001839)1.89201141
115Methylmalonic acidemia (HP:0002912)1.88102875
116Segmental peripheral demyelination/remyelination (HP:0003481)1.87803194
117Cupped ribs (HP:0000887)1.87746782
118Testicular atrophy (HP:0000029)1.86876879
119Fat malabsorption (HP:0002630)1.86646532
120Abnormality of polysaccharide metabolism (HP:0011012)1.86536862
121Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86536862
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86536862
123Leukodystrophy (HP:0002415)1.85453453
124Hyperinsulinemic hypoglycemia (HP:0000825)1.84805229
125Cardiovascular calcification (HP:0011915)1.84791018
126Alopecia of scalp (HP:0002293)1.82984231
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82429439
128Short femoral neck (HP:0100864)1.82284773
129Thoracolumbar scoliosis (HP:0002944)1.81821658
130Abnormality of dentin (HP:0010299)1.81300414
131Nuclear cataract (HP:0100018)1.81169172
132Secondary amenorrhea (HP:0000869)1.80462722
133Epiphyseal stippling (HP:0010655)1.79953583
134Vascular calcification (HP:0004934)1.79748927
135Congenital, generalized hypertrichosis (HP:0004540)1.79408756
136Mucopolysacchariduria (HP:0008155)1.79253381
137Urinary glycosaminoglycan excretion (HP:0003541)1.79253381
138Hyperglycinemia (HP:0002154)1.78243971
139Abnormality of urine glucose concentration (HP:0011016)1.78166602
140Glycosuria (HP:0003076)1.78166602
141Abnormality of methionine metabolism (HP:0010901)1.76700947
142Increased CSF lactate (HP:0002490)1.76351634
143CNS hypomyelination (HP:0003429)1.76146301
144Hypoglycemic coma (HP:0001325)1.75660272
145Nonimmune hydrops fetalis (HP:0001790)1.75114794
146Abnormality of the costochondral junction (HP:0000919)1.75068973
147Increased hepatocellular lipid droplets (HP:0006565)1.74110011
148Medial flaring of the eyebrow (HP:0010747)1.73008645
149Onycholysis (HP:0001806)1.72791556
150Aplastic anemia (HP:0001915)1.71970804
151Atrophic scars (HP:0001075)1.71872660
152Vitreoretinal degeneration (HP:0000655)1.71685625
153Hypoplasia of the uterus (HP:0000013)1.69835988
154Conjugated hyperbilirubinemia (HP:0002908)1.69276692
155Hypoglycemic seizures (HP:0002173)1.69218680
156Submucous cleft hard palate (HP:0000176)1.68857784
157Hypothermia (HP:0002045)1.67618627
158Hepatocellular necrosis (HP:0001404)1.67514998
159Abnormality of liposaccharide metabolism (HP:0010968)1.65497782
160Abnormality of glycosphingolipid metabolism (HP:0004343)1.65497782
161Abnormality of glycolipid metabolism (HP:0010969)1.65497782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.27794405
2MAP3K123.84686778
3EIF2AK32.95569860
4PBK2.89844878
5STK162.78874754
6MST42.76046478
7OXSR12.67530785
8EPHB12.61701476
9MYLK2.53998638
10WNK42.53263320
11MAPK152.30444701
12IRAK32.23130250
13VRK22.13480858
14NME21.96269055
15IRAK11.89996565
16BCR1.89179462
17NEK61.85771652
18BCKDK1.85554015
19PAK41.79667212
20MET1.78297394
21MST1R1.74529605
22INSRR1.73962553
23IRAK41.71035953
24ARAF1.63964001
25TESK21.62888659
26NEK11.61328854
27TRIM281.60347123
28PIM21.52068582
29MAPKAPK51.50866586
30DYRK21.50008781
31TBK11.49297443
32EIF2AK11.46460425
33ACVR1B1.42320972
34IRAK21.41850528
35CASK1.39881452
36LIMK11.36695988
37EPHA31.33527228
38ERN11.31809700
39NUAK11.29627377
40NME11.28618033
41PKN11.25062387
42KDR1.22641593
43BUB11.19279160
44TGFBR21.17728603
45TNIK1.13948721
46MAPKAPK31.13893999
47ILK1.13141438
48ADRBK21.12750991
49TAOK31.10963461
50MAP2K21.07085896
51NLK1.03103372
52ABL21.02710205
53SIK31.01415538
54VRK11.00185808
55MAP3K30.97903680
56CSNK1G30.97363497
57PIK3CG0.96039619
58PIK3CA0.94484887
59BMPR20.92437721
60MAP3K130.91694418
61CAMK2B0.91225600
62BMPR1B0.89472310
63AKT30.88172905
64CSNK1A1L0.84966254
65RPS6KA50.83757911
66CAMK2D0.83421455
67IKBKE0.82726180
68CSNK1G10.82534816
69PLK40.81891817
70CDK80.81801593
71STK38L0.81506260
72EPHB20.81144738
73CAMK2G0.80198735
74PRKCE0.79870303
75MOS0.78398598
76TAOK20.76879210
77ERBB30.76667221
78DAPK30.75340739
79STK100.74200512
80ERBB40.74104935
81HIPK20.72645055
82FLT30.71611805
83MAP4K20.70840736
84MUSK0.69322870
85DDR20.67644167
86TLK10.65827224
87BRAF0.65444326
88GRK70.64917422
89PRKCQ0.63872779
90PTK20.63770038
91TESK10.63047672
92FGR0.62332647
93FRK0.62291926
94PINK10.61871816
95MAP3K140.59698498
96STK240.58902825
97PLK20.58625875
98DAPK10.58456764
99SRPK10.58195900
100WNK10.57395589
101MAP3K110.56631430
102CSNK1A10.55045005
103CLK10.54911556
104TYK20.53297529
105CDK30.53275565
106CHUK0.52740206
107TTK0.51383420
108WNK30.51198821
109FER0.50737936
110IKBKB0.50449016
111PASK0.50388225
112EIF2AK20.49183381
113CSNK1G20.48598693
114STK30.48163084
115PDK20.47364611
116CSNK2A10.47289287
117TEC0.45553601
118PLK30.45027397
119PRKCI0.43864295
120MAP3K50.43861005
121MATK0.43587405
122GSK3A0.43311997
123AURKA0.42905753
124LMTK20.42847335
125JAK10.42583684
126PLK10.42502377
127GRK10.40072646
128NTRK10.38556049
129PAK10.38266033
130MKNK10.38111084
131PRKG20.38086081
132ITK0.37942379
133BRSK20.37913638
134MAPKAPK20.37014039
135CAMK2A0.36717368
136LYN0.36662000
137TIE10.36531574
138MAP3K80.36156748
139CDK190.36000790
140PAK30.35241362
141TXK0.34254705
142MKNK20.34144118
143ROCK10.34025632
144AURKB0.32923110
145ABL10.32289321
146CSK0.31803056
147EPHA20.31126688
148ZAK0.30324065
149PRKACA0.29936991

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.00340601
2Steroid biosynthesis_Homo sapiens_hsa001003.83707783
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.49726015
4Sulfur metabolism_Homo sapiens_hsa009203.06099980
5Vitamin B6 metabolism_Homo sapiens_hsa007502.95527126
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.87889400
7Fatty acid elongation_Homo sapiens_hsa000622.73593411
8Oxidative phosphorylation_Homo sapiens_hsa001902.39044207
9Sphingolipid metabolism_Homo sapiens_hsa006002.16865454
10Folate biosynthesis_Homo sapiens_hsa007902.12989543
11Proteasome_Homo sapiens_hsa030502.07420179
12RNA polymerase_Homo sapiens_hsa030202.02641266
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98077470
14Ether lipid metabolism_Homo sapiens_hsa005651.91517714
15Histidine metabolism_Homo sapiens_hsa003401.78814295
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78294480
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75699868
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75590171
19* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68347742
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65916164
21Linoleic acid metabolism_Homo sapiens_hsa005911.58006695
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57051975
23Parkinsons disease_Homo sapiens_hsa050121.51008184
24Other glycan degradation_Homo sapiens_hsa005111.45863356
25Vibrio cholerae infection_Homo sapiens_hsa051101.41277079
26Lysosome_Homo sapiens_hsa041421.40728745
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38966458
28Arginine and proline metabolism_Homo sapiens_hsa003301.38350466
29Arachidonic acid metabolism_Homo sapiens_hsa005901.34569700
30Vitamin digestion and absorption_Homo sapiens_hsa049771.33109222
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31776351
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31420995
33Regulation of autophagy_Homo sapiens_hsa041401.29209321
34Alzheimers disease_Homo sapiens_hsa050101.25392455
35Caffeine metabolism_Homo sapiens_hsa002321.24517130
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23262734
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21513112
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16496678
39Fructose and mannose metabolism_Homo sapiens_hsa000511.13483946
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12469386
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10480907
42Glutathione metabolism_Homo sapiens_hsa004801.09983807
43Butanoate metabolism_Homo sapiens_hsa006501.09387088
44Galactose metabolism_Homo sapiens_hsa000521.08543502
45Huntingtons disease_Homo sapiens_hsa050161.06145110
46Peroxisome_Homo sapiens_hsa041461.05166049
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03688793
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03640712
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.02293713
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98812793
51Collecting duct acid secretion_Homo sapiens_hsa049660.98211179
52Rheumatoid arthritis_Homo sapiens_hsa053230.96891407
53Basal transcription factors_Homo sapiens_hsa030220.92818083
54N-Glycan biosynthesis_Homo sapiens_hsa005100.91640445
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89038046
56Metabolic pathways_Homo sapiens_hsa011000.87460121
57Chemical carcinogenesis_Homo sapiens_hsa052040.85845243
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.84064714
59Phagosome_Homo sapiens_hsa041450.82888158
60Legionellosis_Homo sapiens_hsa051340.82465616
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80815182
62Protein digestion and absorption_Homo sapiens_hsa049740.80146743
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.78910390
64Shigellosis_Homo sapiens_hsa051310.78753114
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77696950
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76778050
67Antigen processing and presentation_Homo sapiens_hsa046120.75198439
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.74961743
69Retinol metabolism_Homo sapiens_hsa008300.73686168
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72135575
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70389150
72Salmonella infection_Homo sapiens_hsa051320.69886394
73Pertussis_Homo sapiens_hsa051330.69066284
74PPAR signaling pathway_Homo sapiens_hsa033200.67907537
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.67852032
76Pancreatic secretion_Homo sapiens_hsa049720.67804156
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66631980
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63625398
79beta-Alanine metabolism_Homo sapiens_hsa004100.63368839
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.62694569
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62154656
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61754101
83Fat digestion and absorption_Homo sapiens_hsa049750.60862375
84Carbon metabolism_Homo sapiens_hsa012000.60346092
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.60302670
86Propanoate metabolism_Homo sapiens_hsa006400.59658291
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59218215
88Nitrogen metabolism_Homo sapiens_hsa009100.58926747
89Sulfur relay system_Homo sapiens_hsa041220.58314462
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58175319
91Pyrimidine metabolism_Homo sapiens_hsa002400.57982209
92Ribosome_Homo sapiens_hsa030100.57223780
93Malaria_Homo sapiens_hsa051440.57096505
94Tyrosine metabolism_Homo sapiens_hsa003500.56696839
95Nucleotide excision repair_Homo sapiens_hsa034200.55578525
96Fatty acid metabolism_Homo sapiens_hsa012120.55055969
97Starch and sucrose metabolism_Homo sapiens_hsa005000.54073671
98Selenocompound metabolism_Homo sapiens_hsa004500.52968654
99Cardiac muscle contraction_Homo sapiens_hsa042600.51822746
100Pentose phosphate pathway_Homo sapiens_hsa000300.51731547
101TNF signaling pathway_Homo sapiens_hsa046680.51241267
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50913764
103Tryptophan metabolism_Homo sapiens_hsa003800.49488111
104Purine metabolism_Homo sapiens_hsa002300.49245778
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49177308
106Complement and coagulation cascades_Homo sapiens_hsa046100.46053124
107Graft-versus-host disease_Homo sapiens_hsa053320.41792832
108Mineral absorption_Homo sapiens_hsa049780.39738020
109Asthma_Homo sapiens_hsa053100.37833834
110Renin-angiotensin system_Homo sapiens_hsa046140.37727808
111Fatty acid degradation_Homo sapiens_hsa000710.37083431
112Phenylalanine metabolism_Homo sapiens_hsa003600.36140605
113Autoimmune thyroid disease_Homo sapiens_hsa053200.35605334
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35294463
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31588793
116Prion diseases_Homo sapiens_hsa050200.29236585
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28624589
118Glycerolipid metabolism_Homo sapiens_hsa005610.24153934
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23891141
120ECM-receptor interaction_Homo sapiens_hsa045120.23740071
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23011017
122Pyruvate metabolism_Homo sapiens_hsa006200.22753212
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22252290
124Staphylococcus aureus infection_Homo sapiens_hsa051500.21929798
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.21337622
126Allograft rejection_Homo sapiens_hsa053300.17338514
127Type I diabetes mellitus_Homo sapiens_hsa049400.17102948

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