VEZT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91862286
2neuron cell-cell adhesion (GO:0007158)4.82957333
3vocalization behavior (GO:0071625)4.71722136
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65555834
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.43902976
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38409597
7protein localization to synapse (GO:0035418)4.35837788
8response to pheromone (GO:0019236)4.34607509
9regulation of glutamate receptor signaling pathway (GO:1900449)4.17938541
10glutamate receptor signaling pathway (GO:0007215)4.10760202
11pyrimidine nucleobase catabolic process (GO:0006208)4.10159197
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98694317
13neuron recognition (GO:0008038)3.92786686
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.91890065
15synaptic vesicle exocytosis (GO:0016079)3.90520496
16synaptic transmission, glutamatergic (GO:0035249)3.90148785
17axonal fasciculation (GO:0007413)3.86550940
18presynaptic membrane assembly (GO:0097105)3.83819399
19postsynaptic membrane organization (GO:0001941)3.76476520
20locomotory exploration behavior (GO:0035641)3.76083978
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75804316
22neuron-neuron synaptic transmission (GO:0007270)3.66171136
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60437760
24regulation of synaptic vesicle exocytosis (GO:2000300)3.58060731
25cerebellar Purkinje cell differentiation (GO:0021702)3.55966294
26presynaptic membrane organization (GO:0097090)3.55087100
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52138616
28nonmotile primary cilium assembly (GO:0035058)3.51114517
29neuronal action potential propagation (GO:0019227)3.49230550
30neurotransmitter-gated ion channel clustering (GO:0072578)3.40682192
31nucleobase catabolic process (GO:0046113)3.38971657
32glutamate secretion (GO:0014047)3.38627791
33neurotransmitter secretion (GO:0007269)3.37628046
34membrane depolarization during action potential (GO:0086010)3.34235816
35regulation of neuronal synaptic plasticity (GO:0048168)3.33947384
36dendritic spine morphogenesis (GO:0060997)3.30829777
37regulation of synaptic vesicle transport (GO:1902803)3.30670702
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.29781064
39dendrite morphogenesis (GO:0048813)3.29332464
40cell migration in hindbrain (GO:0021535)3.29256852
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26308749
42positive regulation of synapse assembly (GO:0051965)3.26020335
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24842856
44synaptic vesicle endocytosis (GO:0048488)3.23125855
45regulation of postsynaptic membrane potential (GO:0060078)3.22872813
46central nervous system projection neuron axonogenesis (GO:0021952)3.21553107
47startle response (GO:0001964)3.21073813
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.19257193
49exploration behavior (GO:0035640)3.19237014
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19140150
51synaptic vesicle maturation (GO:0016188)3.18626591
52long-term memory (GO:0007616)3.17199429
53limb bud formation (GO:0060174)3.15979816
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.14764348
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13833307
56intraciliary transport (GO:0042073)3.13025218
57regulation of synapse assembly (GO:0051963)3.11729447
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.10091467
59transmission of nerve impulse (GO:0019226)3.09184759
60regulation of synapse structural plasticity (GO:0051823)3.09011697
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08300133
62retinal ganglion cell axon guidance (GO:0031290)3.08262797
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07585761
64calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.06975661
65olfactory bulb development (GO:0021772)3.06198065
66membrane hyperpolarization (GO:0060081)3.04903739
67membrane depolarization (GO:0051899)3.04832888
68synapse assembly (GO:0007416)3.02793209
69negative regulation of dendrite development (GO:2000171)3.01449105
70response to auditory stimulus (GO:0010996)2.99154059
71gamma-aminobutyric acid transport (GO:0015812)2.97325663
72righting reflex (GO:0060013)2.97001459
73ribonucleoprotein complex disassembly (GO:0032988)2.96299735
74DNA double-strand break processing (GO:0000729)2.95723165
75regulation of neurotransmitter secretion (GO:0046928)2.94945079
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94552193
77regulation of respiratory system process (GO:0044065)2.93684651
78layer formation in cerebral cortex (GO:0021819)2.92442533
79neurotransmitter transport (GO:0006836)2.88303079
80auditory behavior (GO:0031223)2.87987841
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87790585
82proline transport (GO:0015824)2.86755853
83positive regulation of membrane potential (GO:0045838)2.84769118
84striatum development (GO:0021756)2.82422159
85detection of calcium ion (GO:0005513)2.81390942
86regulation of synapse maturation (GO:0090128)2.80681525
87learning (GO:0007612)2.80326886
88adult walking behavior (GO:0007628)2.79512067
89neuronal ion channel clustering (GO:0045161)2.79480034
90DNA integration (GO:0015074)2.78640966
91cilium morphogenesis (GO:0060271)2.78438703
92innervation (GO:0060384)2.77901744
93regulation of vesicle fusion (GO:0031338)2.77567155
94regulation of synapse organization (GO:0050807)2.77184441
95mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.77050498
96positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.77050498
97cerebellar granule cell differentiation (GO:0021707)2.75664579
98sympathetic nervous system development (GO:0048485)2.75552302
99regulation of respiratory gaseous exchange (GO:0043576)2.75395847
100dendrite development (GO:0016358)2.75179914
101positive regulation of mitochondrial fission (GO:0090141)2.75169089
102behavioral fear response (GO:0001662)2.74184506
103behavioral defense response (GO:0002209)2.74184506
104response to histamine (GO:0034776)2.73368690
105prepulse inhibition (GO:0060134)2.73292206
106cell communication by electrical coupling (GO:0010644)2.73034277
107neural tube formation (GO:0001841)2.72863484
108regulation of dendritic spine morphogenesis (GO:0061001)2.71915524
109inner ear receptor stereocilium organization (GO:0060122)2.70696673
110central nervous system neuron axonogenesis (GO:0021955)2.69899408
111positive regulation of synapse maturation (GO:0090129)2.68790567
112ganglion development (GO:0061548)2.68061345
113long-term synaptic potentiation (GO:0060291)2.67956776
114neuronal action potential (GO:0019228)2.67831468
115negative regulation of axon guidance (GO:1902668)2.67499230
116regulation of neurotransmitter transport (GO:0051588)2.67113870
117regulation of synaptic transmission, GABAergic (GO:0032228)2.67072469
118positive regulation of potassium ion transmembrane transport (GO:1901381)2.66756397
119regulation of transforming growth factor beta2 production (GO:0032909)2.66749535
120mechanosensory behavior (GO:0007638)2.65867282
121regulation of synaptic plasticity (GO:0048167)2.65201569
122protein prenylation (GO:0018342)2.61475555
123prenylation (GO:0097354)2.61475555
124behavioral response to nicotine (GO:0035095)2.56785206
125glycosphingolipid biosynthetic process (GO:0006688)2.56217944
126cilium organization (GO:0044782)2.53129901
127cilium assembly (GO:0042384)2.52226613
128regulation of sarcomere organization (GO:0060297)2.52121114
129regulation of hexokinase activity (GO:1903299)2.51171770
130regulation of glucokinase activity (GO:0033131)2.51171770
131axon extension involved in axon guidance (GO:0048846)2.48937857
132neuron projection extension involved in neuron projection guidance (GO:1902284)2.48937857
133organelle disassembly (GO:1903008)2.45721956
134photoreceptor cell maintenance (GO:0045494)2.41754297
135protein polyglutamylation (GO:0018095)2.39109381
136keratinocyte development (GO:0003334)2.36125457
137negative chemotaxis (GO:0050919)2.35659253
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.35069081
139fibroblast migration (GO:0010761)2.34372835
140protein localization to cilium (GO:0061512)2.33048253
141microtubule anchoring (GO:0034453)2.31467962
142kidney morphogenesis (GO:0060993)2.26008797
143reflex (GO:0060004)2.24913910
144regulation of axon guidance (GO:1902667)2.24606658
145homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.24395504
146somite development (GO:0061053)2.23882068
147cerebral cortex cell migration (GO:0021795)2.21357918
148regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.17310211
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.16544223
150regulation of translation, ncRNA-mediated (GO:0045974)2.16544223
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.16544223
152hippocampus development (GO:0021766)2.15976265
153cellular component assembly involved in morphogenesis (GO:0010927)2.15835677
154ephrin receptor signaling pathway (GO:0048013)2.12822257
155cerebral cortex development (GO:0021987)2.09444057
156cholesterol biosynthetic process (GO:0006695)2.08375625
157regulation of development, heterochronic (GO:0040034)2.08342887
158regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.08310877
159regulation of telomere maintenance (GO:0032204)2.05861042
160protein K11-linked deubiquitination (GO:0035871)2.05030328
161platelet dense granule organization (GO:0060155)2.04047859
162regulation of cilium movement (GO:0003352)2.02198793
163hindbrain development (GO:0030902)2.01984993
164otic vesicle formation (GO:0030916)2.01971819
165sterol biosynthetic process (GO:0016126)2.00975124
166lipid particle organization (GO:0034389)2.00056659
167appendage development (GO:0048736)1.99764939
168limb development (GO:0060173)1.99764939
169negative regulation of axon extension involved in axon guidance (GO:0048843)1.98831769
170negative regulation of oligodendrocyte differentiation (GO:0048715)1.98607002
171cellular ketone body metabolic process (GO:0046950)1.98339591
172dorsal/ventral axis specification (GO:0009950)1.98310239
173negative regulation of calcium ion-dependent exocytosis (GO:0045955)1.97801387
174magnesium ion transport (GO:0015693)1.97432892
175replication fork processing (GO:0031297)1.97020928
176myelin assembly (GO:0032288)1.96775333
177negative regulation of DNA recombination (GO:0045910)1.96752271
178pyrimidine dimer repair (GO:0006290)1.96542328
179establishment of protein localization to Golgi (GO:0072600)1.96038584
180regulation of keratinocyte proliferation (GO:0010837)1.95994736
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)1.95861461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17336227
2GBX2_23144817_ChIP-Seq_PC3_Human4.16018122
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.96196694
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77462449
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77051349
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66028671
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.53199766
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52054040
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50820136
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39334437
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38518822
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38518822
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37452866
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.37378274
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35128050
16TAF15_26573619_Chip-Seq_HEK293_Human2.23476333
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18475523
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16549883
19EWS_26573619_Chip-Seq_HEK293_Human2.14511818
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09196822
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07866795
22REST_21632747_ChIP-Seq_MESCs_Mouse2.06064356
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.04266571
24DROSHA_22980978_ChIP-Seq_HELA_Human2.03885001
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.00612902
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94996625
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94436998
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92262137
29AR_21572438_ChIP-Seq_LNCaP_Human1.90666522
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89492927
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89297137
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83641796
33SMAD4_21799915_ChIP-Seq_A2780_Human1.82320848
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.81960371
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81528493
36P300_19829295_ChIP-Seq_ESCs_Human1.75597361
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74745899
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74472374
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74111970
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69655373
41IGF1R_20145208_ChIP-Seq_DFB_Human1.67756751
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63168904
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58035586
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57118418
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.56991441
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56986576
47ELK1_19687146_ChIP-ChIP_HELA_Human1.54171578
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.50821011
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49955524
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.48744257
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47489542
52RNF2_27304074_Chip-Seq_NSC_Mouse1.46779680
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.45364752
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43361805
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.43188393
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43135950
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42021298
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40376354
59CBP_20019798_ChIP-Seq_JUKART_Human1.40376354
60STAT3_23295773_ChIP-Seq_U87_Human1.39071225
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36936526
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35211436
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34690277
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34502281
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33851466
66* AR_25329375_ChIP-Seq_VCAP_Human1.33630848
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33110140
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32334564
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31225537
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30742894
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30468972
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29444500
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.29410726
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28831959
75FUS_26573619_Chip-Seq_HEK293_Human1.27567168
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27546017
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.27516550
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27376511
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.27127863
80ZNF274_21170338_ChIP-Seq_K562_Hela1.26983427
81TCF4_23295773_ChIP-Seq_U87_Human1.25484262
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.25436208
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25373655
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25373655
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25011350
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24667648
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24667648
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24623662
89AHR_22903824_ChIP-Seq_MCF-7_Human1.22505210
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22203725
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21582932
92TCF4_22108803_ChIP-Seq_LS180_Human1.20725585
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18669318
94RUNX2_22187159_ChIP-Seq_PCA_Human1.18584672
95ER_23166858_ChIP-Seq_MCF-7_Human1.18298624
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18215191
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18155585
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16859326
99BCAT_22108803_ChIP-Seq_LS180_Human1.16795125
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.16716939
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16340988
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.15856621
103TP53_18474530_ChIP-ChIP_U2OS_Human1.15783660
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14464721
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.14357470
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13042455
107* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12936927
108VDR_22108803_ChIP-Seq_LS180_Human1.12689308
109P53_22387025_ChIP-Seq_ESCs_Mouse1.11882011
110* AR_19668381_ChIP-Seq_PC3_Human1.11655001
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.10727258
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10696790
113* FLI1_21867929_ChIP-Seq_TH2_Mouse1.10114547
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08711795
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07775462
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07262506
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07233765
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07094809
119SOX9_26525672_Chip-Seq_HEART_Mouse1.06356336
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.06274029
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.05296159
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.04415110
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03532386
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.03452922
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03418922
126SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03123132
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02953929
128KDM2B_26808549_Chip-Seq_REH_Human1.02285077
129TP53_16413492_ChIP-PET_HCT116_Human1.02283687
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02258035
131KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02084746
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.01075643
133GABP_17652178_ChIP-ChIP_JURKAT_Human1.00234619
134* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00138754
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99710503
136NANOG_19829295_ChIP-Seq_ESCs_Human0.99258305
137SOX2_19829295_ChIP-Seq_ESCs_Human0.99258305
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98203137
139JUN_21703547_ChIP-Seq_K562_Human0.97656419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.59079094
2MP0003880_abnormal_central_pattern4.42947250
3MP0003635_abnormal_synaptic_transmissio3.31463530
4MP0004270_analgesia3.08228349
5MP0001968_abnormal_touch/_nociception2.86176571
6MP0002063_abnormal_learning/memory/cond2.83267943
7MP0009745_abnormal_behavioral_response2.80633769
8MP0009046_muscle_twitch2.78979528
9MP0006276_abnormal_autonomic_nervous2.77023541
10MP0002735_abnormal_chemical_nociception2.72024356
11MP0005423_abnormal_somatic_nervous2.58219451
12MP0002734_abnormal_mechanical_nocicepti2.56045930
13MP0000569_abnormal_digit_pigmentation2.55324752
14MP0001486_abnormal_startle_reflex2.51730541
15MP0002064_seizures2.50354009
16MP0005645_abnormal_hypothalamus_physiol2.47378828
17MP0002572_abnormal_emotion/affect_behav2.46916744
18MP0000778_abnormal_nervous_system2.33501072
19MP0002736_abnormal_nociception_after2.33146569
20MP0003122_maternal_imprinting2.28263883
21MP0002272_abnormal_nervous_system2.25478451
22MP0001984_abnormal_olfaction2.15705721
23MP0005646_abnormal_pituitary_gland2.07334470
24MP0001440_abnormal_grooming_behavior2.02472758
25MP0002067_abnormal_sensory_capabilities2.01725869
26MP0002184_abnormal_innervation1.98276702
27MP0001188_hyperpigmentation1.95087383
28MP0002733_abnormal_thermal_nociception1.93238179
29MP0000383_abnormal_hair_follicle1.85373274
30MP0002557_abnormal_social/conspecific_i1.85290708
31MP0001501_abnormal_sleep_pattern1.84286137
32MP0001970_abnormal_pain_threshold1.80844939
33MP0003787_abnormal_imprinting1.77651726
34MP0003890_abnormal_embryonic-extraembry1.76750333
35MP0000647_abnormal_sebaceous_gland1.75002957
36MP0008789_abnormal_olfactory_epithelium1.70686692
37MP0002234_abnormal_pharynx_morphology1.65839754
38MP0003937_abnormal_limbs/digits/tail_de1.63667568
39MP0010678_abnormal_skin_adnexa1.62830960
40MP0004924_abnormal_behavior1.58497732
41MP0005386_behavior/neurological_phenoty1.58497732
42MP0001529_abnormal_vocalization1.58345305
43MP0001502_abnormal_circadian_rhythm1.58160557
44MP0008877_abnormal_DNA_methylation1.57776434
45MP0009780_abnormal_chondrocyte_physiolo1.52415119
46MP0005187_abnormal_penis_morphology1.51789616
47MP0000427_abnormal_hair_cycle1.51694122
48MP0002822_catalepsy1.49252875
49MP0004742_abnormal_vestibular_system1.45479306
50MP0004133_heterotaxia1.43781484
51MP0000955_abnormal_spinal_cord1.43504661
52MP0002233_abnormal_nose_morphology1.43154923
53MP0002882_abnormal_neuron_morphology1.42802167
54MP0005551_abnormal_eye_electrophysiolog1.42713663
55MP0004811_abnormal_neuron_physiology1.41217404
56MP0008569_lethality_at_weaning1.41017404
57MP0010386_abnormal_urinary_bladder1.36060611
58MP0004147_increased_porphyrin_level1.31262530
59MP0004858_abnormal_nervous_system1.31231512
60MP0002102_abnormal_ear_morphology1.30423471
61MP0004142_abnormal_muscle_tone1.29299538
62MP0000516_abnormal_urinary_system1.28959277
63MP0005367_renal/urinary_system_phenotyp1.28959277
64MP0002638_abnormal_pupillary_reflex1.27953479
65MP0003121_genomic_imprinting1.26944805
66MP0003755_abnormal_palate_morphology1.25689822
67MP0005409_darkened_coat_color1.25235759
68MP0002066_abnormal_motor_capabilities/c1.21956552
69MP0009697_abnormal_copulation1.19813656
70MP0002938_white_spotting1.19471628
71MP0000751_myopathy1.13440479
72MP0005171_absent_coat_pigmentation1.13433935
73MP0002876_abnormal_thyroid_physiology1.13259792
74MP0004145_abnormal_muscle_electrophysio1.12711074
75MP0001286_abnormal_eye_development1.10724959
76MP0001293_anophthalmia1.09242722
77MP0002697_abnormal_eye_size1.07307940
78MP0003567_abnormal_fetal_cardiomyocyte1.07126135
79MP0002152_abnormal_brain_morphology1.05322864
80MP0006292_abnormal_olfactory_placode1.04489797
81MP0000013_abnormal_adipose_tissue1.04296669
82MP0003941_abnormal_skin_development1.03784256
83MP0005391_vision/eye_phenotype1.03201686
84MP0003119_abnormal_digestive_system1.02928112
85MP0000631_abnormal_neuroendocrine_gland1.02843463
86MP0001963_abnormal_hearing_physiology1.01617271
87MP0002752_abnormal_somatic_nervous1.01191017
88MP0005253_abnormal_eye_physiology0.99816328
89MP0004885_abnormal_endolymph0.99329831
90MP0003879_abnormal_hair_cell0.98731356
91MP0001299_abnormal_eye_distance/0.96993225
92MP0001905_abnormal_dopamine_level0.96817262
93MP0003633_abnormal_nervous_system0.96436791
94MP0003935_abnormal_craniofacial_develop0.95901301
95MP0000566_synostosis0.93692744
96MP0000026_abnormal_inner_ear0.93064104
97MP0003137_abnormal_impulse_conducting0.92831676
98MP0006054_spinal_hemorrhage0.92272164
99MP0000537_abnormal_urethra_morphology0.91920494
100MP0001177_atelectasis0.91470483
101MP0001986_abnormal_taste_sensitivity0.91444185
102MP0005394_taste/olfaction_phenotype0.89317947
103MP0005499_abnormal_olfactory_system0.89317947
104MP0002090_abnormal_vision0.88947286
105MP0002069_abnormal_eating/drinking_beha0.88424278
106MP0005195_abnormal_posterior_eye0.88346862
107MP0002229_neurodegeneration0.88210648
108MP0002084_abnormal_developmental_patter0.87689428
109MP0003221_abnormal_cardiomyocyte_apopto0.86842260
110MP0003631_nervous_system_phenotype0.86613503
111MP0009703_decreased_birth_body0.86248254
112MP0008058_abnormal_DNA_repair0.85907289
113MP0002751_abnormal_autonomic_nervous0.85867441
114MP0000049_abnormal_middle_ear0.85739242
115MP0001879_abnormal_lymphatic_vessel0.85625530
116MP0000579_abnormal_nail_morphology0.84859992
117MP0004085_abnormal_heartbeat0.84805359
118MP0001346_abnormal_lacrimal_gland0.83578076
119MP0003385_abnormal_body_wall0.82693667
120MP0004197_abnormal_fetal_growth/weight/0.80725224
121MP0008995_early_reproductive_senescence0.79826121
122MP0008775_abnormal_heart_ventricle0.79052022
123MP0002909_abnormal_adrenal_gland0.78282769
124MP0004215_abnormal_myocardial_fiber0.77608894
125MP0002837_dystrophic_cardiac_calcinosis0.76541739
126MP0006072_abnormal_retinal_apoptosis0.74072517
127MP0003329_amyloid_beta_deposits0.70053290
128MP0000538_abnormal_urinary_bladder0.69862146
129MP0004484_altered_response_of0.69101293
130MP0003634_abnormal_glial_cell0.67957174
131MP0003183_abnormal_peptide_metabolism0.67047953
132MP0003861_abnormal_nervous_system0.66822517
133MP0000015_abnormal_ear_pigmentation0.66082940
134MP0005248_abnormal_Harderian_gland0.65822004
135MP0003632_abnormal_nervous_system0.65511212
136MP0008872_abnormal_physiological_respon0.63560317
137MP0001485_abnormal_pinna_reflex0.63259387
138MP0008260_abnormal_autophagy0.62473098
139MP0001943_abnormal_respiration0.60324873
140MP0002163_abnormal_gland_morphology0.60095154
141MP0002082_postnatal_lethality0.57463957
142MP0010770_preweaning_lethality0.57463957

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.64718275
2Febrile seizures (HP:0002373)5.38817546
3Focal seizures (HP:0007359)4.93393225
4Epileptic encephalopathy (HP:0200134)4.28935441
5Myokymia (HP:0002411)4.22029946
6Atonic seizures (HP:0010819)3.86508146
7Progressive cerebellar ataxia (HP:0002073)3.75520619
8Broad-based gait (HP:0002136)3.73420930
9Polyphagia (HP:0002591)3.61449869
10Hyperventilation (HP:0002883)3.59573652
11Generalized tonic-clonic seizures (HP:0002069)3.38932900
12Absence seizures (HP:0002121)3.26749140
13True hermaphroditism (HP:0010459)3.25762452
14Excessive salivation (HP:0003781)3.21426933
15Drooling (HP:0002307)3.21426933
16Dialeptic seizures (HP:0011146)3.13155866
17Pancreatic cysts (HP:0001737)3.12268688
18Pancreatic fibrosis (HP:0100732)3.07921892
19Exotropia (HP:0000577)3.00483147
20Protruding tongue (HP:0010808)2.99039549
21Abnormal eating behavior (HP:0100738)2.95553456
22Action tremor (HP:0002345)2.88458167
23Gaze-evoked nystagmus (HP:0000640)2.84928734
24Abnormal hair whorl (HP:0010721)2.83079795
25Failure to thrive in infancy (HP:0001531)2.82330622
26Abnormality of midbrain morphology (HP:0002418)2.81241918
27Molar tooth sign on MRI (HP:0002419)2.81241918
28Absent speech (HP:0001344)2.75053247
29Gait imbalance (HP:0002141)2.65180281
30Visual hallucinations (HP:0002367)2.63199559
31Supranuclear gaze palsy (HP:0000605)2.59355824
32Blue irides (HP:0000635)2.56948246
33Poor eye contact (HP:0000817)2.56420201
34Exercise-induced muscle cramps (HP:0003710)2.53725395
35Hemiparesis (HP:0001269)2.53267069
36Esotropia (HP:0000565)2.48997677
37Nephronophthisis (HP:0000090)2.48506518
38Scanning speech (HP:0002168)2.47540723
39Truncal ataxia (HP:0002078)2.47199082
40Renal cortical cysts (HP:0000803)2.45085890
41Impaired vibration sensation in the lower limbs (HP:0002166)2.44607167
42Dysdiadochokinesis (HP:0002075)2.43518395
43Intestinal atresia (HP:0011100)2.43195010
44Poor coordination (HP:0002370)2.41900135
45Abnormality of the renal cortex (HP:0011035)2.34165645
46Abnormality of salivation (HP:0100755)2.33970200
47Urinary bladder sphincter dysfunction (HP:0002839)2.32149933
48Volvulus (HP:0002580)2.32074494
49Amblyopia (HP:0000646)2.31833581
50Epileptiform EEG discharges (HP:0011182)2.31682868
51Bifid tongue (HP:0010297)2.30434523
52Abnormality of the renal medulla (HP:0100957)2.30374031
53Tubulointerstitial nephritis (HP:0001970)2.29606311
54Prolonged QT interval (HP:0001657)2.26952775
55Congenital primary aphakia (HP:0007707)2.24868716
56Medial flaring of the eyebrow (HP:0010747)2.24832159
57Specific learning disability (HP:0001328)2.24673540
58Abnormal social behavior (HP:0012433)2.24315215
59Impaired social interactions (HP:0000735)2.24315215
60Agitation (HP:0000713)2.24085739
61Sleep apnea (HP:0010535)2.19155989
62Postaxial hand polydactyly (HP:0001162)2.19014462
63EEG with generalized epileptiform discharges (HP:0011198)2.18797206
64Nephrogenic diabetes insipidus (HP:0009806)2.18443218
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.18037800
66Fair hair (HP:0002286)2.16838453
67Lissencephaly (HP:0001339)2.15238511
68Fetal akinesia sequence (HP:0001989)2.14810497
69Genetic anticipation (HP:0003743)2.14506994
70Renal hypoplasia (HP:0000089)2.13904799
71Limb dystonia (HP:0002451)2.12877529
72Generalized hypopigmentation of hair (HP:0011358)2.11903748
73Progressive inability to walk (HP:0002505)2.11507759
74Genital tract atresia (HP:0001827)2.10816023
75Aqueductal stenosis (HP:0002410)2.09527230
76Abnormality of the corticospinal tract (HP:0002492)2.09183829
77Astrocytoma (HP:0009592)2.08757600
78Abnormality of the astrocytes (HP:0100707)2.08757600
79Ankle clonus (HP:0011448)2.07132890
80Papillary thyroid carcinoma (HP:0002895)2.06491228
81Cortical dysplasia (HP:0002539)2.05163339
82Cerebellar dysplasia (HP:0007033)2.04872547
83Rimmed vacuoles (HP:0003805)2.03277241
84Narrow nasal bridge (HP:0000446)2.01006465
85Hypsarrhythmia (HP:0002521)2.00149887
86Dysmetria (HP:0001310)1.99790725
87Vaginal atresia (HP:0000148)1.99690943
88Colon cancer (HP:0003003)1.99451642
89Inability to walk (HP:0002540)1.99248478
90Open mouth (HP:0000194)1.99067978
91Labial hypoplasia (HP:0000066)1.97738771
92Pheochromocytoma (HP:0002666)1.97432223
93Occipital encephalocele (HP:0002085)1.96582643
94Postaxial foot polydactyly (HP:0001830)1.95981894
95Decreased central vision (HP:0007663)1.95957334
96Abnormal EKG (HP:0003115)1.95637550
97Sclerocornea (HP:0000647)1.95606981
98Postural instability (HP:0002172)1.95476162
99Decreased testicular size (HP:0008734)1.94776807
100Central scotoma (HP:0000603)1.93979229
101Lower limb amyotrophy (HP:0007210)1.92356765
102Anxiety (HP:0000739)1.92343151
103Hypoventilation (HP:0002791)1.91416490
104Type II lissencephaly (HP:0007260)1.91408513
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.91243771
106Depression (HP:0000716)1.91051861
107Spastic gait (HP:0002064)1.90643210
108Medulloblastoma (HP:0002885)1.90613327
109Hypothermia (HP:0002045)1.89868487
110Broad foot (HP:0001769)1.89487621
111Abnormality of the musculature of the pelvis (HP:0001469)1.88868070
112Abnormality of the hip-girdle musculature (HP:0001445)1.88868070
113Chronic hepatic failure (HP:0100626)1.88033946
114Glioma (HP:0009733)1.87612780
115Abnormality of the parathyroid morphology (HP:0011766)1.86885075
116Hepatoblastoma (HP:0002884)1.85110846
117Cystic liver disease (HP:0006706)1.84181478
118Micropenis (HP:0000054)1.84143127
119Short foot (HP:0001773)1.83566457
120Thyroid carcinoma (HP:0002890)1.82079499
121Hypoplasia of the brainstem (HP:0002365)1.81941008
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81941008
123Aplasia involving bones of the extremities (HP:0009825)1.81586745
124Aplasia involving bones of the upper limbs (HP:0009823)1.81586745
125Aplasia of the phalanges of the hand (HP:0009802)1.81586745
126Neonatal respiratory distress (HP:0002643)1.81476764
127Abnormal biliary tract physiology (HP:0012439)1.79888574
128Bile duct proliferation (HP:0001408)1.79888574
129Thyroid-stimulating hormone excess (HP:0002925)1.78665281
130Optic nerve hypoplasia (HP:0000609)1.78549663
131Urinary urgency (HP:0000012)1.78234135
132Stereotypic behavior (HP:0000733)1.77955079
133Preaxial hand polydactyly (HP:0001177)1.77673824
134Insidious onset (HP:0003587)1.77445592
135Termporal pattern (HP:0011008)1.77445592
136Abnormality of the labia minora (HP:0012880)1.77396100
137Mutism (HP:0002300)1.76824950
138Anencephaly (HP:0002323)1.76610669
139Lower limb muscle weakness (HP:0007340)1.76562188
140Absent eyebrow (HP:0002223)1.76037764
141Cupped ear (HP:0000378)1.75997257
142Congenital stationary night blindness (HP:0007642)1.74786230
143Dyschromatopsia (HP:0007641)1.74474756
144Midline defect of the nose (HP:0004122)1.74464578
145Autism (HP:0000717)1.74247922
146Narrow forehead (HP:0000341)1.73378192
147Astigmatism (HP:0000483)1.72683713
148Short tibia (HP:0005736)1.72622090
149Dandy-Walker malformation (HP:0001305)1.72557077
150Shoulder girdle muscle weakness (HP:0003547)1.71868371
151Anophthalmia (HP:0000528)1.71498795
152Cutaneous finger syndactyly (HP:0010554)1.71311901
153Pachygyria (HP:0001302)1.71095031
154Syncope (HP:0001279)1.70924870
155Bradycardia (HP:0001662)1.69438241
156Abnormal ciliary motility (HP:0012262)1.69040548
157Aplasia/Hypoplasia of the lens (HP:0008063)1.68955501
158Inappropriate behavior (HP:0000719)1.68553176
159Hypoplastic female external genitalia (HP:0012815)1.68071762
160Abnormality of binocular vision (HP:0011514)1.67993640
161Calf muscle hypertrophy (HP:0008981)1.67853811
162Left ventricular hypertrophy (HP:0001712)1.66589826
163Muscle hypertrophy of the lower extremities (HP:0008968)1.65114796
164Male pseudohermaphroditism (HP:0000037)1.60156263
165Scrotal hypoplasia (HP:0000046)1.58708069
166Tubular atrophy (HP:0000092)1.58486223
167Furrowed tongue (HP:0000221)1.57119780
168Tubulointerstitial abnormality (HP:0001969)1.56781434
169Hypoplastic labia majora (HP:0000059)1.56503157
170Chorioretinal atrophy (HP:0000533)1.51172329
171Hyperglycinemia (HP:0002154)1.51005177
172Long clavicles (HP:0000890)1.49911358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.09474139
2CASK3.94819807
3MARK13.28995648
4FRK3.27279739
5TRIM283.19435454
6MAP2K72.96252021
7EPHA42.91415884
8MAP3K42.79520104
9TNIK2.49124653
10MAP4K22.44283336
11WNK32.14860418
12MAP3K92.10479181
13MAPK132.07182319
14INSRR2.05376131
15PRPF4B2.02065855
16NTRK21.96756877
17MINK11.86595465
18MAP3K121.75582018
19DAPK21.69573539
20MAP2K41.68603822
21EIF2AK31.67759643
22SRPK11.67634196
23KSR11.62663844
24BRSK21.61163565
25MKNK21.59695783
26SGK21.49600681
27SIK21.49212734
28PAK61.47946515
29SGK4941.44354594
30SGK2231.44354594
31CSNK1G11.44133706
32SIK31.44119323
33PHKG21.44053022
34PHKG11.44053022
35STK38L1.42398978
36CAMK1G1.35187842
37BCR1.31744014
38ERBB31.29122314
39EPHB21.28829925
40CSNK1G31.28666159
41MKNK11.27958400
42PLK21.27200205
43CDK51.25708182
44NEK11.18435710
45RIPK41.17998164
46MST41.14740775
47PLK31.12566623
48GRK11.10878384
49PRKCG1.10028060
50VRK11.09217106
51UHMK11.07345878
52CAMK2A1.07033760
53STK391.06503646
54NTRK11.06109879
55BMPR1B1.05785002
56CAMKK21.05563357
57WEE11.04894655
58PNCK1.03478726
59NUAK11.02628546
60ACVR1B0.99925128
61BMPR20.99335532
62SGK30.96710644
63AKT30.94435384
64TSSK60.94150396
65ZAK0.90761737
66PRKCE0.89917009
67NEK60.88581205
68BRD40.87414780
69MET0.87233605
70CAMK2B0.86691091
71FLT30.86167913
72OXSR10.84623801
73CAMK1D0.84548964
74SGK10.84403445
75LMTK20.81147080
76PAK30.80488627
77PKN10.79766457
78DAPK10.79120617
79ADRBK20.78666251
80DYRK1A0.78227812
81FES0.78070673
82TGFBR10.77941515
83CAMKK10.75396796
84CAMK10.75277437
85GRK50.75008686
86DYRK20.72487836
87TNK20.71218285
88TIE10.68302703
89LATS10.67584113
90ERBB40.67201017
91CSNK1G20.66916882
92DYRK30.65371688
93CCNB10.64772646
94PINK10.64417199
95YES10.64409269
96FER0.63326140
97CDK30.63292216
98LIMK10.63084213
99RPS6KA40.62815571
100CDK190.61921653
101CAMK2D0.60578972
102STK380.60315694
103WNK10.59993281
104FGFR10.58405408
105PRKCH0.58010148
106GRK70.57624765
107MARK20.57506927
108FGFR20.57330707
109NLK0.57306213
110PLK10.56293074
111CDK80.56062886
112CDK180.56027009
113CAMK40.55625582
114ADRBK10.54227259
115STK110.53636983
116PRKD30.53079901
117CDC42BPA0.52880579
118KSR20.52653732
119PRKCZ0.52144456
120STK30.51615345
121CDK150.48221606
122ATM0.48210789
123ERBB20.48191471
124IRAK20.48187595
125CSNK1D0.47525165
126PRKG10.46595008
127PKN20.45502236
128PRKAA10.45310583
129EIF2AK20.45046607
130EPHA30.44652879
131PIK3CA0.44564666
132MAP3K130.44510921
133CAMK2G0.44193661
134RPS6KA20.44175805
135CDK140.44036876
136CSNK1A1L0.43370243
137CSNK1A10.41570519
138ROCK10.41481871
139RPS6KA30.41159444
140OBSCN0.41007736
141PRKCB0.40420860
142PRKACA0.39586060
143FYN0.38971606
144EIF2AK10.38784502
145PLK40.38539188
146FGR0.36815085
147MUSK0.34494986
148PBK0.33472689
149BCKDK0.32112545
150DYRK1B0.32001869
151CSNK1E0.31429431
152NEK90.30048074

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.32675253
2Synaptic vesicle cycle_Homo sapiens_hsa047212.82006349
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69947446
4Protein export_Homo sapiens_hsa030602.69866881
5Morphine addiction_Homo sapiens_hsa050322.55411923
6Steroid biosynthesis_Homo sapiens_hsa001002.53959543
7GABAergic synapse_Homo sapiens_hsa047272.52371423
8Glutamatergic synapse_Homo sapiens_hsa047242.51227913
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.49791555
10Circadian entrainment_Homo sapiens_hsa047132.48156109
11Olfactory transduction_Homo sapiens_hsa047402.44601980
12Butanoate metabolism_Homo sapiens_hsa006502.30639670
13Propanoate metabolism_Homo sapiens_hsa006402.21124088
14Taste transduction_Homo sapiens_hsa047422.20766320
15Long-term potentiation_Homo sapiens_hsa047202.08791991
16Amphetamine addiction_Homo sapiens_hsa050312.08366982
17Insulin secretion_Homo sapiens_hsa049111.95891333
18Dopaminergic synapse_Homo sapiens_hsa047281.93132697
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90060417
20Serotonergic synapse_Homo sapiens_hsa047261.90026025
21Non-homologous end-joining_Homo sapiens_hsa034501.80679465
22Salivary secretion_Homo sapiens_hsa049701.80515629
23Phototransduction_Homo sapiens_hsa047441.79427374
24Cholinergic synapse_Homo sapiens_hsa047251.76658743
25Basal transcription factors_Homo sapiens_hsa030221.69524693
26Collecting duct acid secretion_Homo sapiens_hsa049661.67329412
27Axon guidance_Homo sapiens_hsa043601.64636533
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64492305
29Calcium signaling pathway_Homo sapiens_hsa040201.62066827
30Fanconi anemia pathway_Homo sapiens_hsa034601.59682126
31Cocaine addiction_Homo sapiens_hsa050301.59482311
32Long-term depression_Homo sapiens_hsa047301.53079319
33Renin secretion_Homo sapiens_hsa049241.51936258
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48364404
35Oxytocin signaling pathway_Homo sapiens_hsa049211.46452484
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45557044
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44305167
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41604191
39Selenocompound metabolism_Homo sapiens_hsa004501.40816933
40Gastric acid secretion_Homo sapiens_hsa049711.34265132
41Type II diabetes mellitus_Homo sapiens_hsa049301.30741763
42Gap junction_Homo sapiens_hsa045401.24688812
43cAMP signaling pathway_Homo sapiens_hsa040241.22170649
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21557880
45Hippo signaling pathway_Homo sapiens_hsa043901.21503359
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21453204
47Homologous recombination_Homo sapiens_hsa034401.21121407
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20889859
49RNA degradation_Homo sapiens_hsa030181.19093456
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18117031
51Cardiac muscle contraction_Homo sapiens_hsa042601.14394824
52GnRH signaling pathway_Homo sapiens_hsa049121.14361729
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14350263
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08611764
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08371058
56ErbB signaling pathway_Homo sapiens_hsa040121.07831419
57Nitrogen metabolism_Homo sapiens_hsa009101.07646802
58Dilated cardiomyopathy_Homo sapiens_hsa054141.07542652
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07053459
60TGF-beta signaling pathway_Homo sapiens_hsa043501.05957759
61Peroxisome_Homo sapiens_hsa041461.05009970
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03650765
63Fatty acid elongation_Homo sapiens_hsa000621.01735088
64Melanogenesis_Homo sapiens_hsa049161.00485442
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99903835
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.99309694
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98465483
68Tight junction_Homo sapiens_hsa045300.91555186
69Vibrio cholerae infection_Homo sapiens_hsa051100.91192747
70Tryptophan metabolism_Homo sapiens_hsa003800.90869898
71RNA transport_Homo sapiens_hsa030130.89660317
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88632791
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.88391806
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87832083
75Fatty acid metabolism_Homo sapiens_hsa012120.87096112
76Sulfur metabolism_Homo sapiens_hsa009200.86133076
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85276504
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.84482210
79Caffeine metabolism_Homo sapiens_hsa002320.84413272
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82825289
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81338213
82Ether lipid metabolism_Homo sapiens_hsa005650.80423934
83Glioma_Homo sapiens_hsa052140.79850715
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79353370
85Estrogen signaling pathway_Homo sapiens_hsa049150.77374583
86MAPK signaling pathway_Homo sapiens_hsa040100.76906100
87Choline metabolism in cancer_Homo sapiens_hsa052310.75280352
88Parkinsons disease_Homo sapiens_hsa050120.74539040
89Adherens junction_Homo sapiens_hsa045200.74268975
90Nucleotide excision repair_Homo sapiens_hsa034200.74189117
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.73654764
92Pancreatic secretion_Homo sapiens_hsa049720.72922406
93Dorso-ventral axis formation_Homo sapiens_hsa043200.72023232
94Circadian rhythm_Homo sapiens_hsa047100.71837762
95RNA polymerase_Homo sapiens_hsa030200.70296539
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68426685
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67686384
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67682923
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67036797
100beta-Alanine metabolism_Homo sapiens_hsa004100.65190200
101Wnt signaling pathway_Homo sapiens_hsa043100.64702795
102Lysine degradation_Homo sapiens_hsa003100.64407531
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63779309
104Ovarian steroidogenesis_Homo sapiens_hsa049130.63682901
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.63530649
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63388013
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63040624
108mRNA surveillance pathway_Homo sapiens_hsa030150.61965131
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61276646
110Ras signaling pathway_Homo sapiens_hsa040140.59556160
111ABC transporters_Homo sapiens_hsa020100.57736178
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57633407
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57185891
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55640190
115Type I diabetes mellitus_Homo sapiens_hsa049400.55479062
116Huntingtons disease_Homo sapiens_hsa050160.54506497
117Alcoholism_Homo sapiens_hsa050340.53793039
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.53540179
119Phagosome_Homo sapiens_hsa041450.53218928
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53032808
121Endometrial cancer_Homo sapiens_hsa052130.52872725
122Mismatch repair_Homo sapiens_hsa034300.51860949
123Thyroid hormone synthesis_Homo sapiens_hsa049180.51436054
124One carbon pool by folate_Homo sapiens_hsa006700.51333863
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51062002
126Alzheimers disease_Homo sapiens_hsa050100.49990954
127Hedgehog signaling pathway_Homo sapiens_hsa043400.49869107
128Rheumatoid arthritis_Homo sapiens_hsa053230.48556109
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47602771
130Inositol phosphate metabolism_Homo sapiens_hsa005620.47118052
131Rap1 signaling pathway_Homo sapiens_hsa040150.46958044
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.46895947
133Glucagon signaling pathway_Homo sapiens_hsa049220.45706879
134Arginine and proline metabolism_Homo sapiens_hsa003300.45662083
135Metabolic pathways_Homo sapiens_hsa011000.45093122
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44304860
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.43054310
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42242856
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42008880
140Fatty acid degradation_Homo sapiens_hsa000710.41914597
141AMPK signaling pathway_Homo sapiens_hsa041520.41535466
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40597433
143Insulin signaling pathway_Homo sapiens_hsa049100.39053344
144African trypanosomiasis_Homo sapiens_hsa051430.36412333
145Oxidative phosphorylation_Homo sapiens_hsa001900.36330568
146Oocyte meiosis_Homo sapiens_hsa041140.36047886
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35488565
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34895792
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34455178
150Melanoma_Homo sapiens_hsa052180.34381126
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34176863
152Basal cell carcinoma_Homo sapiens_hsa052170.34173556
153Regulation of autophagy_Homo sapiens_hsa041400.32765773
154Fatty acid biosynthesis_Homo sapiens_hsa000610.30560066
155Mineral absorption_Homo sapiens_hsa049780.29558462
156Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29472672
157Colorectal cancer_Homo sapiens_hsa052100.29248120
158Renal cell carcinoma_Homo sapiens_hsa052110.28865129

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