VEGFC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)5.71374887
2blood vessel maturation (GO:0001955)4.78959030
3type B pancreatic cell proliferation (GO:0044342)4.65274894
4hemidesmosome assembly (GO:0031581)4.64187132
5chondrocyte proliferation (GO:0035988)4.60939964
6endothelial tube morphogenesis (GO:0061154)4.59084659
7morphogenesis of an endothelium (GO:0003159)4.59084659
8vascular endothelial growth factor signaling pathway (GO:0038084)4.43928727
9definitive hemopoiesis (GO:0060216)4.34399390
10lymph vessel development (GO:0001945)4.22946058
11regulation of glucose import in response to insulin stimulus (GO:2001273)4.08781119
12extracellular matrix assembly (GO:0085029)4.06645830
13paraxial mesoderm development (GO:0048339)4.06504319
14cell migration involved in heart development (GO:0060973)4.03074963
15basement membrane organization (GO:0071711)4.01410210
16cell-substrate junction assembly (GO:0007044)3.94331696
17endothelium development (GO:0003158)3.92206918
18cellular response to vitamin (GO:0071295)3.91955059
19cellular response to interleukin-6 (GO:0071354)3.79670526
20virion attachment to host cell (GO:0019062)3.79192133
21adhesion of symbiont to host cell (GO:0044650)3.79192133
22Notch signaling involved in heart development (GO:0061314)3.74955498
23cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.73886337
24lymphangiogenesis (GO:0001946)3.73454543
25heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.72834436
26endocardial cushion development (GO:0003197)3.70609227
27collagen metabolic process (GO:0032963)3.69348732
28negative regulation of smooth muscle cell migration (GO:0014912)3.65605555
29regulation of plasminogen activation (GO:0010755)3.64227045
30protein retention in ER lumen (GO:0006621)3.63719131
31protein heterotrimerization (GO:0070208)3.62819245
32hypotonic response (GO:0006971)3.62699996
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.61571585
34sequestering of extracellular ligand from receptor (GO:0035581)3.56926446
35protein localization to endosome (GO:0036010)3.55309560
36Golgi transport vesicle coating (GO:0048200)3.54475688
37COPI coating of Golgi vesicle (GO:0048205)3.54475688
38cellular response to vitamin D (GO:0071305)3.53143860
39epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.50252628
40collagen catabolic process (GO:0030574)3.47440634
41stress fiber assembly (GO:0043149)3.45211174
42endocardial cushion morphogenesis (GO:0003203)3.44922608
43endothelial cell morphogenesis (GO:0001886)3.43637882
44outer ear morphogenesis (GO:0042473)3.41565177
45sprouting angiogenesis (GO:0002040)3.41244320
46* positive regulation of blood vessel endothelial cell migration (GO:0043536)3.38835499
47collagen fibril organization (GO:0030199)3.38280749
48multicellular organismal macromolecule metabolic process (GO:0044259)3.37837953
49viral transcription (GO:0019083)3.32632685
50translational termination (GO:0006415)3.31503074
51ribosomal small subunit assembly (GO:0000028)3.29369967
52extracellular negative regulation of signal transduction (GO:1900116)3.27095713
53extracellular regulation of signal transduction (GO:1900115)3.27095713
54dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.26825630
55dermatan sulfate biosynthetic process (GO:0030208)3.26152704
56dermatan sulfate metabolic process (GO:0030205)3.25418890
57adhesion of symbiont to host (GO:0044406)3.25180194
58extracellular matrix disassembly (GO:0022617)3.25091502
59hyaluronan catabolic process (GO:0030214)3.22362685
60cell adhesion mediated by integrin (GO:0033627)3.22120376
61negative regulation of chondrocyte differentiation (GO:0032331)3.21510038
62platelet dense granule organization (GO:0060155)3.20720089
63barbed-end actin filament capping (GO:0051016)3.19849943
64* substrate-dependent cell migration (GO:0006929)3.19115651
65multicellular organismal metabolic process (GO:0044236)3.18937178
66membrane raft organization (GO:0031579)3.18740672
67glomerular basement membrane development (GO:0032836)3.18012686
68negative regulation of axon extension involved in axon guidance (GO:0048843)3.17417532
69retina vasculature morphogenesis in camera-type eye (GO:0061299)3.17074151
70negative regulation of nitric-oxide synthase activity (GO:0051001)3.15801961
71muscle cell migration (GO:0014812)3.15341347
72cell migration involved in sprouting angiogenesis (GO:0002042)3.14636132
73multicellular organismal catabolic process (GO:0044243)3.14462660
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.11109220
75regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.10847935
76positive regulation of fibroblast migration (GO:0010763)3.10805912
77cardiac epithelial to mesenchymal transition (GO:0060317)3.08978297
78regulation of endothelial cell differentiation (GO:0045601)3.08493582
79actin filament depolymerization (GO:0030042)3.04762160
80response to interleukin-6 (GO:0070741)3.04281010
81notochord development (GO:0030903)3.01992904
82metanephric mesenchyme development (GO:0072075)3.01660849
83kidney mesenchyme development (GO:0072074)3.01076230
84endodermal cell differentiation (GO:0035987)3.01043821
85trabecula morphogenesis (GO:0061383)3.00122982
86fibril organization (GO:0097435)2.99414065
87positive regulation of osteoblast proliferation (GO:0033690)2.98863497
88extracellular matrix organization (GO:0030198)2.98205565
89peptidyl-proline hydroxylation (GO:0019511)2.97642505
90extracellular structure organization (GO:0043062)2.97331193
91substrate adhesion-dependent cell spreading (GO:0034446)2.96574077
92regulation of vasculogenesis (GO:2001212)2.96334321
93blood vessel remodeling (GO:0001974)2.96298321
94neuron projection extension involved in neuron projection guidance (GO:1902284)2.95237476
95axon extension involved in axon guidance (GO:0048846)2.95237476
96negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.94952367
97cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.93276597
98venous blood vessel morphogenesis (GO:0048845)2.92640590
99wound healing, spreading of cells (GO:0044319)2.91228599
100regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91047276
101negative regulation of fatty acid transport (GO:2000192)2.90981626
102wound healing, spreading of epidermal cells (GO:0035313)2.90210609
103vasculogenesis (GO:0001570)2.89738397
104regulation of extracellular matrix disassembly (GO:0010715)2.89450874
105bone trabecula formation (GO:0060346)2.89211069
106protein hydroxylation (GO:0018126)2.86684826
107adherens junction assembly (GO:0034333)2.86505840
108cellular response to leptin stimulus (GO:0044320)2.85905870
109aorta morphogenesis (GO:0035909)2.85448221
110response to interferon-beta (GO:0035456)2.84669010
111cell-substrate adherens junction assembly (GO:0007045)2.83572981
112focal adhesion assembly (GO:0048041)2.83572981
113negative regulation of BMP signaling pathway (GO:0030514)2.83562105
114mesenchyme morphogenesis (GO:0072132)2.82910764
115regulation of integrin-mediated signaling pathway (GO:2001044)2.82007075
116keratan sulfate catabolic process (GO:0042340)2.81435001
117extracellular fibril organization (GO:0043206)2.80874133
118COPII vesicle coating (GO:0048208)2.79117027
119blood vessel endothelial cell migration (GO:0043534)2.78926443
120response to interferon-alpha (GO:0035455)2.78595532
121cellular response to amino acid stimulus (GO:0071230)2.77967446
122pericardium development (GO:0060039)2.77647762
123regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.77556497
124regulation of smooth muscle cell migration (GO:0014910)2.76936299
125positive regulation of vasculogenesis (GO:2001214)2.75758884
126positive regulation of astrocyte differentiation (GO:0048711)2.75103301
127apoptotic cell clearance (GO:0043277)2.74756871
128negative regulation of anoikis (GO:2000811)2.74635412
129response to magnesium ion (GO:0032026)2.74505908
130regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.73925973
131heart trabecula morphogenesis (GO:0061384)2.73787735
132labyrinthine layer blood vessel development (GO:0060716)2.70869402
133endothelial cell differentiation (GO:0045446)2.70483163
134cell proliferation involved in metanephros development (GO:0072203)2.70371705
135translational elongation (GO:0006414)2.68981848
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68393131
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65487618
138artery development (GO:0060840)2.64213130
139cell surface receptor signaling pathway involved in heart development (GO:0061311)2.63925155
140ribosomal small subunit biogenesis (GO:0042274)2.63098589
141maturation of SSU-rRNA (GO:0030490)2.62690031
142trabecula formation (GO:0060343)2.61825400
143protein targeting to ER (GO:0045047)2.61378048
144epoxygenase P450 pathway (GO:0019373)2.60971933
145artery morphogenesis (GO:0048844)2.58931093
146endothelial cell proliferation (GO:0001935)2.58224550
147mRNA transcription from RNA polymerase II promoter (GO:0042789)2.58126993
148glomerular filtration (GO:0003094)2.57768782
149cotranslational protein targeting to membrane (GO:0006613)2.57238203
150outflow tract morphogenesis (GO:0003151)2.56393339
151negative regulation of glucose import (GO:0046325)2.56326746
152heart trabecula formation (GO:0060347)2.55803514
153ventricular trabecula myocardium morphogenesis (GO:0003222)2.53852615
154growth hormone receptor signaling pathway (GO:0060396)2.53515003
155renal filtration (GO:0097205)2.52755133
156smooth muscle tissue development (GO:0048745)2.52712461
157regulation of SMAD protein import into nucleus (GO:0060390)2.51672698
158negative regulation of blood vessel endothelial cell migration (GO:0043537)2.50598405
159atrioventricular valve morphogenesis (GO:0003181)2.50093746
160mesodermal cell differentiation (GO:0048333)2.49018079
161mRNA transcription (GO:0009299)2.48628123
162response to fluid shear stress (GO:0034405)2.48587218
163tooth mineralization (GO:0034505)2.48538944
164regulation of heart morphogenesis (GO:2000826)2.48200093
165mesenchymal-epithelial cell signaling (GO:0060638)2.48046593
166positive regulation of endothelial cell apoptotic process (GO:2000353)2.47818325
167regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.47684506
168positive regulation of BMP signaling pathway (GO:0030513)2.47643361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.08752373
2CLOCK_20551151_ChIP-Seq_293T_Human3.46976394
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.36097530
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18021754
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.07146496
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.07146496
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.07146496
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.95266191
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69520466
10E2F7_22180533_ChIP-Seq_HELA_Human2.53992515
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.52860584
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47149760
13* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.44597992
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42664714
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42115977
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34583786
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.31699821
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.29488766
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.26891936
20STAT3_1855785_ChIP-Seq_MESCs_Mouse2.22878585
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.21471862
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.19087986
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14594165
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14167171
25ZNF263_19887448_ChIP-Seq_K562_Human2.12118860
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99423987
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.99143459
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97974761
29TP53_18474530_ChIP-ChIP_U2OS_Human1.96239351
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.94555076
31* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93388168
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.90304410
33SCL_19346495_ChIP-Seq_HPC-7_Human1.85516359
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.83425249
35* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.83404352
36UBF1/2_26484160_Chip-Seq_HMECs_Human1.82988229
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77862935
38* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.76423484
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75559483
40TP53_22127205_ChIP-Seq_IMR90_Human1.75122330
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.71092587
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.70646188
43TP53_16413492_ChIP-PET_HCT116_Human1.69271016
44* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66580814
45* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66580814
46BRD4_25478319_ChIP-Seq_HGPS_Human1.65677297
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64237300
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.62565869
49* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61353158
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56274729
51* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.53836149
52* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53080714
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47520176
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47135015
55* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41858065
56TP53_23651856_ChIP-Seq_MEFs_Mouse1.40960701
57SA1_22415368_ChIP-Seq_MEFs_Mouse1.40594841
58* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39982222
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38315368
60* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37603251
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.36851206
62* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35266829
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35189487
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35180140
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34916743
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34365242
67* CJUN_26792858_Chip-Seq_BT549_Human1.33350837
68* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32949852
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32855063
70* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31978294
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31550329
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30668601
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28987065
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.28975924
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28180753
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27926413
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27745041
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.27016873
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25752752
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23443559
81* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22951093
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.21588022
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.21588022
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21566526
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20590283
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19749448
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19462222
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19072735
89SOX2_20726797_ChIP-Seq_SW620_Human1.18622462
90MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18374309
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16741572
92EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16741572
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16653785
94* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15857076
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15723318
96* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15481053
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15430444
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15368613
99P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14995269
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.14879984
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13804515
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13804515
103* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13035514
104* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12931872
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12600594
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.11558191
107AR_21909140_ChIP-Seq_LNCAP_Human1.11555381
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10870414
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.10246790
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08534973
111TP53_20018659_ChIP-ChIP_R1E_Mouse1.08257950
112* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06578211
113* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05471118
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04704075
115* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04355063
116NCOR1_26117541_ChIP-Seq_K562_Human1.03848388
117MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03771265
118SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03754636
119RACK7_27058665_Chip-Seq_MCF-7_Human1.03744894
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03249499
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01797743
122ATF3_27146783_Chip-Seq_COLON_Human1.01679821
123* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00999555
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00630803
125ELK1_22589737_ChIP-Seq_MCF10A_Human1.00376423
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99814626
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99450845
128* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99057747
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97730914
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97271766
131* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96973045
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.95691779
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95236739
134NFI_21473784_ChIP-Seq_ESCs_Mouse0.93678926
135* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93473628
136XRN2_22483619_ChIP-Seq_HELA_Human0.93264006
137TP63_23658742_ChIP-Seq_EP156T_Human0.93216770
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93164827
139PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.92891390
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.91331760
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91065935
142* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90196472
143PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.89378566
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84379870
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.83483220
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82437240
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.80989593
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.80871476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010368_abnormal_lymphatic_system4.84716774
2MP0008438_abnormal_cutaneous_collagen4.80996733
3MP0005503_abnormal_tendon_morphology3.77742634
4MP0003279_aneurysm3.65891011
5* MP0001879_abnormal_lymphatic_vessel3.47949423
6MP0005275_abnormal_skin_tensile3.19757533
7MP0004272_abnormal_basement_membrane3.16847821
8MP0003705_abnormal_hypodermis_morpholog2.97623201
9MP0003950_abnormal_plasma_membrane2.89308958
10MP0006054_spinal_hemorrhage2.80571878
11MP0009384_cardiac_valve_regurgitation2.59274261
12MP0001958_emphysema2.30536378
13MP0009250_abnormal_appendicular_skeleto1.99039612
14MP0003828_pulmonary_edema1.94712293
15MP0003566_abnormal_cell_adhesion1.93973253
16MP0009379_abnormal_foot_pigmentation1.89406374
17MP0005623_abnormal_meninges_morphology1.86903857
18MP0005023_abnormal_wound_healing1.86701205
19MP0009780_abnormal_chondrocyte_physiolo1.86014001
20MP0000767_abnormal_smooth_muscle1.80871299
21MP0000013_abnormal_adipose_tissue1.78931795
22MP0002138_abnormal_hepatobiliary_system1.76361327
23MP0010030_abnormal_orbit_morphology1.71240812
24MP0005508_abnormal_skeleton_morphology1.69266580
25MP0000751_myopathy1.61790138
26MP0002249_abnormal_larynx_morphology1.61430283
27MP0003724_increased_susceptibility_to1.51139173
28MP0003385_abnormal_body_wall1.49959908
29MP0000534_abnormal_ureter_morphology1.45487182
30* MP0002128_abnormal_blood_circulation1.37244043
31MP0005167_abnormal_blood-brain_barrier1.32741642
32MP0009053_abnormal_anal_canal1.31432491
33MP0001299_abnormal_eye_distance/1.30307073
34MP0001270_distended_abdomen1.27946278
35MP0004084_abnormal_cardiac_muscle1.27898095
36MP0001348_abnormal_lacrimal_gland1.26202619
37MP0003806_abnormal_nucleotide_metabolis1.25176545
38MP0003567_abnormal_fetal_cardiomyocyte1.24675723
39MP0000762_abnormal_tongue_morphology1.21192771
40MP0006138_congestive_heart_failure1.21106382
41MP0002295_abnormal_pulmonary_circulatio1.20734723
42MP0000049_abnormal_middle_ear1.20434837
43MP0002877_abnormal_melanocyte_morpholog1.18866250
44MP0003091_abnormal_cell_migration1.18618018
45MP0005408_hypopigmentation1.16588613
46MP0001614_abnormal_blood_vessel1.16563773
47MP0004808_abnormal_hematopoietic_stem1.16551338
48MP0010352_gastrointestinal_tract_polyps1.12163689
49MP0008007_abnormal_cellular_replicative1.11754006
50MP0002925_abnormal_cardiovascular_devel1.10137343
51MP0002127_abnormal_cardiovascular_syste1.08797704
52MP0004858_abnormal_nervous_system1.08420018
53MP0000163_abnormal_cartilage_morphology1.08303470
54MP0005084_abnormal_gallbladder_morpholo1.07453941
55MP0004134_abnormal_chest_morphology1.07312121
56MP0003941_abnormal_skin_development1.05116691
57MP0000733_abnormal_muscle_development1.04970094
58MP0000003_abnormal_adipose_tissue1.03689501
59MP0000749_muscle_degeneration1.03656762
60MP0002108_abnormal_muscle_morphology1.03602366
61MP0005595_abnormal_vascular_smooth1.02558500
62MP0010386_abnormal_urinary_bladder1.02317172
63MP0005257_abnormal_intraocular_pressure1.01230192
64MP0001243_abnormal_dermal_layer0.99300802
65MP0001915_intracranial_hemorrhage0.98553104
66MP0000759_abnormal_skeletal_muscle0.97870349
67MP0003191_abnormal_cellular_cholesterol0.97695592
68MP0005197_abnormal_uvea_morphology0.96456265
69MP0001849_ear_inflammation0.96339531
70MP0001542_abnormal_bone_strength0.93409706
71MP0005409_darkened_coat_color0.92958853
72MP0003448_altered_tumor_morphology0.92581706
73MP0005385_cardiovascular_system_phenoty0.92529915
74MP0001544_abnormal_cardiovascular_syste0.92529915
75MP0003943_abnormal_hepatobiliary_system0.91634238
76MP0003935_abnormal_craniofacial_develop0.91275029
77MP0000343_altered_response_to0.90707529
78MP0002113_abnormal_skeleton_development0.89318618
79MP0002115_abnormal_skeleton_extremities0.89162095
80MP0003300_gastrointestinal_ulcer0.88726709
81MP0002086_abnormal_extraembryonic_tissu0.88492664
82MP0000537_abnormal_urethra_morphology0.88394753
83MP0005390_skeleton_phenotype0.87785684
84MP0002060_abnormal_skin_morphology0.86607365
85MP0010630_abnormal_cardiac_muscle0.85731225
86MP0003755_abnormal_palate_morphology0.85447584
87MP0001175_abnormal_lung_morphology0.85392400
88MP0002233_abnormal_nose_morphology0.84820767
89MP0000249_abnormal_blood_vessel0.84035446
90MP0000266_abnormal_heart_morphology0.82612620
91MP0004133_heterotaxia0.81969552
92MP0000467_abnormal_esophagus_morphology0.81777688
93MP0002896_abnormal_bone_mineralization0.80795583
94MP0000516_abnormal_urinary_system0.80732950
95MP0005367_renal/urinary_system_phenotyp0.80732950
96MP0005165_increased_susceptibility_to0.79306737
97MP0001545_abnormal_hematopoietic_system0.78899594
98MP0005397_hematopoietic_system_phenotyp0.78899594
99MP0002177_abnormal_outer_ear0.77421922
100MP0002282_abnormal_trachea_morphology0.76780368
101MP0002998_abnormal_bone_remodeling0.76363408
102MP0004510_myositis0.75645569
103MP0000432_abnormal_head_morphology0.74278965
104MP0002933_joint_inflammation0.74202149
105MP0000465_gastrointestinal_hemorrhage0.73484173
106MP0000428_abnormal_craniofacial_morphol0.72910464
107MP0009278_abnormal_bone_marrow0.71503049
108MP0002168_other_aberrant_phenotype0.71186611
109MP0005164_abnormal_response_to0.71176766
110MP0003942_abnormal_urinary_system0.70216779
111MP0002088_abnormal_embryonic_growth/wei0.69335099
112MP0003984_embryonic_growth_retardation0.68657690
113MP0004197_abnormal_fetal_growth/weight/0.68085834
114MP0002396_abnormal_hematopoietic_system0.67754603
115MP0000750_abnormal_muscle_regeneration0.67714161
116MP0003186_abnormal_redox_activity0.67550164
117MP0002932_abnormal_joint_morphology0.67109407
118MP0003795_abnormal_bone_structure0.66552409
119MP0005365_abnormal_bile_salt0.65765847
120MP0000858_altered_metastatic_potential0.65727297
121MP0004957_abnormal_blastocyst_morpholog0.65343791
122MP0008932_abnormal_embryonic_tissue0.65285385
123MP0005193_abnormal_anterior_eye0.64986345
124MP0009840_abnormal_foam_cell0.64080931
125MP0004883_abnormal_blood_vessel0.63894085
126MP0002116_abnormal_craniofacial_bone0.63335356
127MP0004233_abnormal_muscle_weight0.62356153
128MP0001533_abnormal_skeleton_physiology0.62132191
129MP0002109_abnormal_limb_morphology0.61041835
130MP0001730_embryonic_growth_arrest0.60823654
131MP0002114_abnormal_axial_skeleton0.59473099
132MP0002133_abnormal_respiratory_system0.58564229
133MP0005388_respiratory_system_phenotype0.58564229
134MP0002089_abnormal_postnatal_growth/wei0.56890202
135MP0005171_absent_coat_pigmentation0.56366437
136MP0003115_abnormal_respiratory_system0.56297425
137MP0003283_abnormal_digestive_organ0.52995998
138MP0000681_abnormal_thyroid_gland0.52877338
139MP0004036_abnormal_muscle_relaxation0.51395921
140MP0005621_abnormal_cell_physiology0.51335807

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.40571527
2Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)6.06722719
3Premature rupture of membranes (HP:0001788)5.44341565
4Aplasia/Hypoplasia involving the sinuses (HP:0009120)5.26609009
5Abnormality of the frontal sinuses (HP:0002687)4.62855284
6Follicular hyperkeratosis (HP:0007502)4.59870102
7Vascular tortuosity (HP:0004948)4.54744645
8Type 1 muscle fiber predominance (HP:0003803)4.15691431
9Biconcave vertebral bodies (HP:0004586)4.05222099
10Broad metatarsal (HP:0001783)4.03686558
11Arterial tortuosity (HP:0005116)4.01411805
12Slender build (HP:0001533)3.67928939
13Aortic dissection (HP:0002647)3.51858712
14High anterior hairline (HP:0009890)3.43219148
15Genu recurvatum (HP:0002816)3.41447150
16Abnormality of the columella (HP:0009929)3.34362147
17Cerebral aneurysm (HP:0004944)3.28813784
18Shallow orbits (HP:0000586)3.27853536
19Peritonitis (HP:0002586)3.24582007
20Soft skin (HP:0000977)3.20595934
21Aortic aneurysm (HP:0004942)3.19446717
22Hematochezia (HP:0002573)3.18987263
23Bladder diverticulum (HP:0000015)3.16905221
24Vertebral compression fractures (HP:0002953)3.06546657
25Polycythemia (HP:0001901)3.01730848
26Ankle contracture (HP:0006466)2.97653281
27Wormian bones (HP:0002645)2.94357874
28Mildly elevated creatine phosphokinase (HP:0008180)2.93105600
29Elbow flexion contracture (HP:0002987)2.85345180
30Abnormality of dentin (HP:0010299)2.83260889
31Cervical subluxation (HP:0003308)2.82831405
32Pulmonary artery stenosis (HP:0004415)2.71390758
33Joint laxity (HP:0001388)2.71074124
34Increased variability in muscle fiber diameter (HP:0003557)2.68207128
35Multiple lipomas (HP:0001012)2.67251571
36Neonatal short-limb short stature (HP:0008921)2.66421770
37Cardiovascular calcification (HP:0011915)2.63291379
38Blue sclerae (HP:0000592)2.63071584
39Nonimmune hydrops fetalis (HP:0001790)2.62824708
40Esophageal varix (HP:0002040)2.59065539
41Dilatation of the ascending aorta (HP:0005111)2.58666531
42Spinal rigidity (HP:0003306)2.47209190
43Hypoventilation (HP:0002791)2.38444593
44Achilles tendon contracture (HP:0001771)2.37370499
45Abnormality of skeletal muscle fiber size (HP:0012084)2.33744828
46Atrophic scars (HP:0001075)2.33007083
47Benign neoplasm of the central nervous system (HP:0100835)2.32925656
48Wide anterior fontanel (HP:0000260)2.32554966
49Short nail (HP:0001799)2.31713829
50Mitral regurgitation (HP:0001653)2.30231682
51Joint stiffness (HP:0001387)2.27792157
52Camptodactyly of toe (HP:0001836)2.26036867
53Natal tooth (HP:0000695)2.24901216
54Generalized amyotrophy (HP:0003700)2.24544762
55Aortic valve stenosis (HP:0001650)2.23141884
56Abnormal delivery (HP:0001787)2.22934088
57Bowel diverticulosis (HP:0005222)2.22502268
58Increased connective tissue (HP:0009025)2.20663873
59Mitral stenosis (HP:0001718)2.19657458
60Fragile skin (HP:0001030)2.19069544
61Adactyly (HP:0009776)2.17234480
62Spontaneous hematomas (HP:0007420)2.15558947
63Short hallux (HP:0010109)2.12560186
64Reduced subcutaneous adipose tissue (HP:0003758)2.10149561
65Bronchomalacia (HP:0002780)2.09730492
66Congenital, generalized hypertrichosis (HP:0004540)2.08354508
67Round ear (HP:0100830)2.07868342
68Abnormality of the Achilles tendon (HP:0005109)2.07714832
69Supernumerary spleens (HP:0009799)2.06835338
70Mesomelia (HP:0003027)2.06139859
71Limb-girdle muscle weakness (HP:0003325)2.05424278
72Redundant skin (HP:0001582)2.05355250
73Lymphangioma (HP:0100764)2.02823112
74Disproportionate tall stature (HP:0001519)2.02690605
75Median cleft lip (HP:0000161)2.01611221
76Abnormality of the peritoneum (HP:0002585)2.00850992
77Mitral valve prolapse (HP:0001634)2.00759451
78Distal upper limb amyotrophy (HP:0007149)2.00097624
79Upper limb amyotrophy (HP:0009129)2.00097624
80Syringomyelia (HP:0003396)2.00016315
81Spinal cord lesions (HP:0100561)2.00016315
82Bowing of the arm (HP:0006488)1.98662066
83Bowed forearm bones (HP:0003956)1.98662066
84Absent frontal sinuses (HP:0002688)1.97777810
85Hallux valgus (HP:0001822)1.97075279
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96445833
87Short 4th metacarpal (HP:0010044)1.96445833
88Long toe (HP:0010511)1.96338450
89Aneurysm (HP:0002617)1.95585694
90Aplasia/Hypoplasia of the hallux (HP:0008362)1.95534794
91Radial bowing (HP:0002986)1.94556661
92Coronal craniosynostosis (HP:0004440)1.94349348
93Delayed cranial suture closure (HP:0000270)1.94209313
94Enlarged penis (HP:0000040)1.93605854
95Mild short stature (HP:0003502)1.90343463
96Abnormality of the acetabulum (HP:0003170)1.90250218
97Wrist flexion contracture (HP:0001239)1.90121715
98Ovoid vertebral bodies (HP:0003300)1.89752469
99Deep venous thrombosis (HP:0002625)1.88771842
100Distal lower limb amyotrophy (HP:0008944)1.88319038
101Coxa vara (HP:0002812)1.88281618
102Abnormal hemoglobin (HP:0011902)1.88251854
103Congenital glaucoma (HP:0001087)1.88120072
104Spondylolisthesis (HP:0003302)1.87844707
105Subacute progressive viral hepatitis (HP:0006572)1.87484772
106Thoracolumbar scoliosis (HP:0002944)1.86825626
107Delayed closure of the anterior fontanelle (HP:0001476)1.86662680
108Venous abnormality (HP:0002624)1.86174849
109Renal duplication (HP:0000075)1.86136512
110Flexion contracture of toe (HP:0005830)1.86057526
111Joint contractures involving the joints of the feet (HP:0100492)1.86057526
112Protruding ear (HP:0000411)1.85335142
113Venous insufficiency (HP:0005293)1.84366780
114Entropion (HP:0000621)1.82847207
115Hyperextensible skin (HP:0000974)1.82553618
116Breech presentation (HP:0001623)1.80976363
117Abnormality of skull ossification (HP:0002703)1.79767919
118Knee flexion contracture (HP:0006380)1.78950449
119Chondrocalcinosis (HP:0000934)1.78900055
120Inguinal hernia (HP:0000023)1.78688848
121Short clavicles (HP:0000894)1.75705307
122Portal hypertension (HP:0001409)1.74213715
123Abnormality of carpal bone ossification (HP:0006257)1.73435069
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.72874638
125Osteolytic defects of the hand bones (HP:0009699)1.72874638
126Vascular calcification (HP:0004934)1.72647107
127Decreased skull ossification (HP:0004331)1.72239817
128Abnormality of the incisor (HP:0000676)1.72205550
129Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71367916
130Pulmonary hypertension (HP:0002092)1.70630509
131Overgrowth (HP:0001548)1.70470758
132Conjunctival telangiectasia (HP:0000524)1.70367436
133Mesangial abnormality (HP:0001966)1.70056649
134Hypoplasia of the maxilla (HP:0000327)1.69891921
135Skull defect (HP:0001362)1.69594824
136Absent toe (HP:0010760)1.68712825
137Deviation of the hallux (HP:0010051)1.68468360
138Buphthalmos (HP:0000557)1.67941331
139Broad ribs (HP:0000885)1.67178898
140Selective tooth agenesis (HP:0001592)1.66796765
141Aortic regurgitation (HP:0001659)1.65661168
142Ectopia lentis (HP:0001083)1.64549341
143Preauricular skin tag (HP:0000384)1.64486397
144Slender long bone (HP:0003100)1.64229179
145Asymmetry of the thorax (HP:0001555)1.64200387
146Thrombocytosis (HP:0001894)1.63491813
147Ulnar bowing (HP:0003031)1.62583214
148Missing ribs (HP:0000921)1.62579775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.99226067
2KDR3.26945018
3PKN23.11860073
4TGFBR12.97745875
5TGFBR22.76149765
6NME22.73595448
7TRIB32.66362593
8NTRK12.49710863
9PDGFRA2.40960256
10ERN12.38492084
11EPHB22.36760202
12NEK92.27136513
13FLT32.02616413
14KIT1.89840170
15PRKD21.79820789
16STK381.70027063
17WEE11.65836103
18TTN1.60682605
19PAK41.60285211
20MST1R1.49072508
21ERBB41.48895263
22SIK11.48612452
23RPS6KA41.47819909
24LATS21.45165677
25PAK21.45135956
26DDR21.43663227
27LATS11.38913516
28JAK31.33509957
29IRAK31.33141655
30PRKG21.30785741
31FER1.28602163
32MYLK1.27330348
33KSR21.24577171
34BMX1.20376562
35MAP3K31.14736625
36ILK1.11101169
37ABL21.08608882
38LRRK21.08115263
39EPHA21.07296978
40PIM21.06763966
41CAMK1D1.05715627
42EPHB11.04938611
43CDC42BPA1.04729772
44TAOK21.04519223
45ROCK21.04333453
46PIK3CA1.03597470
47ROCK11.03268808
48SCYL21.02620465
49MAP3K121.02575163
50GRK11.02060819
51GRK71.01837336
52LMTK21.01331838
53PTK2B0.99773750
54STK38L0.99221635
55PAK60.96521254
56MAP2K30.96139174
57CAMKK20.95636986
58ARAF0.94888368
59TBK10.93689163
60MAP3K130.91333916
61MKNK10.88707144
62EIF2AK10.88266628
63RAF10.86103603
64TRPM70.85839082
65MAP3K80.85103431
66ICK0.84698496
67MOS0.83343603
68CDK80.82066454
69PTK60.81119552
70DYRK30.80188244
71CDK60.79168623
72BCKDK0.77972367
73PRPF4B0.77526850
74PTK20.76598897
75MUSK0.75780987
76MAP3K60.75607465
77RPS6KA20.75495590
78INSRR0.75343982
79MELK0.73500622
80MAP3K20.73176089
81GRK50.71787386
82FGFR40.70277460
83WNK10.67778052
84TESK10.67401517
85CSK0.67277407
86CDK70.66085667
87TEC0.65845083
88GSK3A0.65601122
89DYRK1B0.61690946
90TESK20.61555499
91RIPK10.60120876
92MET0.58543379
93EPHA30.57717270
94BUB10.57268826
95PRKD30.57160611
96IGF1R0.56928807
97SMG10.54423976
98PIK3CG0.54120827
99RPS6KB20.53643588
100MAPK70.52844481
101STK240.51627750
102PNCK0.51472301
103MATK0.48236170
104LIMK10.48136961
105ACVR1B0.47019032
106MAP2K10.47004581
107PRKAA20.46451509
108STK100.45089159
109PIM10.44920333
110FGFR10.44860776
111JAK10.42147898
112ERBB30.41929822
113MAPKAPK20.41097173
114MTOR0.39725868
115PLK20.39216568
116CAMK1G0.38625143
117VRK10.38359218
118PAK30.37054881
119INSR0.37017261
120AKT30.36923208
121RET0.36655928
122NEK20.36549747
123CAMK40.35709170
124CAMK2G0.35381523
125ADRBK10.34180615
126STK30.33223923
127DMPK0.32672598
128BRSK20.32565481
129KSR10.31530296
130FGFR30.30951062
131AURKB0.30295211
132PDGFRB0.30043405
133PAK10.29568592
134SRC0.29228780
135ZAP700.29167981
136CLK10.29037402
137TTK0.28380136
138EGFR0.28266547
139MAP3K110.26853326
140DAPK30.26237691
141RPS6KC10.25999795
142RPS6KL10.25999795
143PRKCE0.25321291
144PRKD10.24467347
145BRAF0.21932043
146CDK90.21767078

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.77611000
2Ribosome_Homo sapiens_hsa030103.11181453
3ECM-receptor interaction_Homo sapiens_hsa045122.89048247
4* Focal adhesion_Homo sapiens_hsa045102.25711045
5Complement and coagulation cascades_Homo sapiens_hsa046102.10504086
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.00973357
7TGF-beta signaling pathway_Homo sapiens_hsa043501.88999846
8Cyanoamino acid metabolism_Homo sapiens_hsa004601.86583323
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84566459
10Proteoglycans in cancer_Homo sapiens_hsa052051.77446898
11* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.57802945
12* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56327856
13Small cell lung cancer_Homo sapiens_hsa052221.54588016
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.50867444
15Malaria_Homo sapiens_hsa051441.43497270
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41994180
17Adherens junction_Homo sapiens_hsa045201.41867784
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.40644173
19Glutathione metabolism_Homo sapiens_hsa004801.37724524
20Platelet activation_Homo sapiens_hsa046111.35823333
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33024129
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32752993
23Arginine biosynthesis_Homo sapiens_hsa002201.31809430
24Shigellosis_Homo sapiens_hsa051311.31666976
25Notch signaling pathway_Homo sapiens_hsa043301.31291351
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28954150
27Bladder cancer_Homo sapiens_hsa052191.26264952
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25406458
29DNA replication_Homo sapiens_hsa030301.24579988
30HIF-1 signaling pathway_Homo sapiens_hsa040661.24541536
31Fatty acid degradation_Homo sapiens_hsa000711.22514768
32Hedgehog signaling pathway_Homo sapiens_hsa043401.21253334
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19790881
34Melanoma_Homo sapiens_hsa052181.19750854
35Vibrio cholerae infection_Homo sapiens_hsa051101.16646655
36One carbon pool by folate_Homo sapiens_hsa006701.15934027
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14838404
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.14503483
39MicroRNAs in cancer_Homo sapiens_hsa052061.13802166
40Protein digestion and absorption_Homo sapiens_hsa049741.11918920
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11769643
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11711228
43Prion diseases_Homo sapiens_hsa050201.11559693
44Other glycan degradation_Homo sapiens_hsa005111.10874055
45Dilated cardiomyopathy_Homo sapiens_hsa054141.09883893
46Cell cycle_Homo sapiens_hsa041101.07988272
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07879382
48Mismatch repair_Homo sapiens_hsa034301.06586074
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04897011
50* Pathways in cancer_Homo sapiens_hsa052001.04741418
51Axon guidance_Homo sapiens_hsa043601.03897576
52p53 signaling pathway_Homo sapiens_hsa041151.03840040
53N-Glycan biosynthesis_Homo sapiens_hsa005101.01627332
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01450175
55Chemical carcinogenesis_Homo sapiens_hsa052041.00977207
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00096093
57Pancreatic cancer_Homo sapiens_hsa052120.99526137
58Amoebiasis_Homo sapiens_hsa051460.98891012
59Glioma_Homo sapiens_hsa052140.96892621
60Hippo signaling pathway_Homo sapiens_hsa043900.96200317
61Melanogenesis_Homo sapiens_hsa049160.94698529
62Endocytosis_Homo sapiens_hsa041440.94375630
63Basal cell carcinoma_Homo sapiens_hsa052170.94372126
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93425247
65* Rap1 signaling pathway_Homo sapiens_hsa040150.92765081
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92625844
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92310486
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89509764
69Prostate cancer_Homo sapiens_hsa052150.88693907
70Folate biosynthesis_Homo sapiens_hsa007900.85847662
71Thyroid cancer_Homo sapiens_hsa052160.85012229
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83177198
73PPAR signaling pathway_Homo sapiens_hsa033200.82767435
74Salmonella infection_Homo sapiens_hsa051320.81131937
75Sulfur metabolism_Homo sapiens_hsa009200.80357304
76Chronic myeloid leukemia_Homo sapiens_hsa052200.79854180
77Vitamin digestion and absorption_Homo sapiens_hsa049770.79680289
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76330812
79Arginine and proline metabolism_Homo sapiens_hsa003300.75786045
80Renal cell carcinoma_Homo sapiens_hsa052110.74278683
81HTLV-I infection_Homo sapiens_hsa051660.73998596
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73815315
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72405128
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.70859955
85Lysosome_Homo sapiens_hsa041420.70765285
86Wnt signaling pathway_Homo sapiens_hsa043100.70684535
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67247073
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66673669
89Estrogen signaling pathway_Homo sapiens_hsa049150.65796330
90Phagosome_Homo sapiens_hsa041450.63801223
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63289834
92Homologous recombination_Homo sapiens_hsa034400.63113817
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61350481
94Hepatitis B_Homo sapiens_hsa051610.59988020
95Tryptophan metabolism_Homo sapiens_hsa003800.59775263
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.59586131
97Acute myeloid leukemia_Homo sapiens_hsa052210.59302935
98MAPK signaling pathway_Homo sapiens_hsa040100.59004339
99Toxoplasmosis_Homo sapiens_hsa051450.58613272
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58321031
101GnRH signaling pathway_Homo sapiens_hsa049120.56568183
102ErbB signaling pathway_Homo sapiens_hsa040120.56196630
103Spliceosome_Homo sapiens_hsa030400.55358943
104Leishmaniasis_Homo sapiens_hsa051400.55344801
105Thyroid hormone synthesis_Homo sapiens_hsa049180.55061795
106Galactose metabolism_Homo sapiens_hsa000520.54397629
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.53243209
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53160032
109VEGF signaling pathway_Homo sapiens_hsa043700.52802857
110Endometrial cancer_Homo sapiens_hsa052130.52722941
111Pyrimidine metabolism_Homo sapiens_hsa002400.51736557
112Selenocompound metabolism_Homo sapiens_hsa004500.49733481
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.49313625
114Viral carcinogenesis_Homo sapiens_hsa052030.48961550
115Propanoate metabolism_Homo sapiens_hsa006400.48741473
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.48632867
117Biosynthesis of amino acids_Homo sapiens_hsa012300.47791822
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47587710
119RNA transport_Homo sapiens_hsa030130.47516011
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47177812
121Non-small cell lung cancer_Homo sapiens_hsa052230.47091571
122Nucleotide excision repair_Homo sapiens_hsa034200.46856943
123Insulin resistance_Homo sapiens_hsa049310.46085235
124Bile secretion_Homo sapiens_hsa049760.45795574
125Dorso-ventral axis formation_Homo sapiens_hsa043200.45703110
126Pertussis_Homo sapiens_hsa051330.45591707
127Tight junction_Homo sapiens_hsa045300.45223390
128mTOR signaling pathway_Homo sapiens_hsa041500.45143490
129* TNF signaling pathway_Homo sapiens_hsa046680.43865224
130Renin-angiotensin system_Homo sapiens_hsa046140.43191216
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42840852
132Prolactin signaling pathway_Homo sapiens_hsa049170.42590023
133Staphylococcus aureus infection_Homo sapiens_hsa051500.42136189
134African trypanosomiasis_Homo sapiens_hsa051430.42006324
135Gap junction_Homo sapiens_hsa045400.41766296
136Carbon metabolism_Homo sapiens_hsa012000.39583445
137Pentose phosphate pathway_Homo sapiens_hsa000300.38670743
138Proteasome_Homo sapiens_hsa030500.38314467
139Sphingolipid metabolism_Homo sapiens_hsa006000.38227747
140* Ras signaling pathway_Homo sapiens_hsa040140.37792696
141Apoptosis_Homo sapiens_hsa042100.37418225
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37337838
143Protein export_Homo sapiens_hsa030600.36197655
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.35175131
145Hepatitis C_Homo sapiens_hsa051600.33256092
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31248306
147Cocaine addiction_Homo sapiens_hsa050300.30156898
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28647573
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26999883

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