VDR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.02886550
2Golgi transport vesicle coating (GO:0048200)6.02886550
3desmosome organization (GO:0002934)5.75900463
4endocrine pancreas development (GO:0031018)5.25471269
5* intestinal absorption (GO:0050892)4.85973534
6intestinal epithelial cell development (GO:0060576)4.75381048
7peptide hormone processing (GO:0016486)4.72257365
8hemidesmosome assembly (GO:0031581)4.68801339
9intestinal cholesterol absorption (GO:0030299)4.55727522
10drug transmembrane transport (GO:0006855)4.51974823
11UDP-N-acetylglucosamine metabolic process (GO:0006047)4.50111305
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.40747559
13COPII vesicle coating (GO:0048208)4.39362037
14glandular epithelial cell differentiation (GO:0002067)4.37323669
15aminoglycoside antibiotic metabolic process (GO:0030647)4.32033230
163-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.25655423
17purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.25655423
18bundle of His cell to Purkinje myocyte communication (GO:0086069)4.09239416
19regulation of water loss via skin (GO:0033561)4.07417510
20protein retention in ER lumen (GO:0006621)4.06301672
21hormone catabolic process (GO:0042447)4.00994055
22signal peptide processing (GO:0006465)3.85276571
23drug transport (GO:0015893)3.75443744
24keratinocyte proliferation (GO:0043616)3.73045291
25establishment of skin barrier (GO:0061436)3.71995779
26columnar/cuboidal epithelial cell development (GO:0002066)3.71177579
27renal absorption (GO:0070293)3.69947094
28multicellular organismal water homeostasis (GO:0050891)3.69436537
29angiotensin maturation (GO:0002003)3.60821557
30peptide catabolic process (GO:0043171)3.58559522
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56948341
32glycosphingolipid catabolic process (GO:0046479)3.51987713
33regulation of type B pancreatic cell apoptotic process (GO:2000674)3.51940512
34cellular response to hepatocyte growth factor stimulus (GO:0035729)3.50212096
35response to hepatocyte growth factor (GO:0035728)3.50212096
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48724556
37* cellular response to vitamin D (GO:0071305)3.47751097
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.44100416
39neutrophil activation involved in immune response (GO:0002283)3.43288796
40response to peptidoglycan (GO:0032494)3.36685790
41type B pancreatic cell development (GO:0003323)3.33023903
42antigen processing and presentation of endogenous antigen (GO:0019883)3.32047395
43urate metabolic process (GO:0046415)3.31721680
44cytidine metabolic process (GO:0046087)3.27712128
45cytidine catabolic process (GO:0006216)3.27712128
46cytidine deamination (GO:0009972)3.27712128
47glycolipid catabolic process (GO:0019377)3.26736687
48flavonoid metabolic process (GO:0009812)3.26027795
49sequestering of metal ion (GO:0051238)3.24076687
50regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.23705076
51drug catabolic process (GO:0042737)3.22125220
52* regulation of vitamin metabolic process (GO:0030656)3.20021248
53glandular epithelial cell development (GO:0002068)3.18782221
54vitamin A metabolic process (GO:0006776)3.17848051
55activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.16805374
56phospholipid scrambling (GO:0017121)3.16199936
57virion attachment to host cell (GO:0019062)3.15184697
58adhesion of symbiont to host cell (GO:0044650)3.15184697
59diol metabolic process (GO:0034311)3.14534918
60adhesion of symbiont to host (GO:0044406)3.11340433
61negative regulation of interleukin-12 production (GO:0032695)3.07090701
62regulation of cellular extravasation (GO:0002691)3.04579394
63organic cation transport (GO:0015695)3.02906337
64protein maturation by protein folding (GO:0022417)3.02806399
65regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00979272
66exocrine pancreas development (GO:0031017)3.00955544
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00216498
68detection of other organism (GO:0098543)2.98232936
69membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.97559569
70positive regulation of nuclease activity (GO:0032075)2.96417205
71macrophage activation involved in immune response (GO:0002281)2.95847277
72ceramide catabolic process (GO:0046514)2.95604134
73positive regulation of Cdc42 GTPase activity (GO:0043089)2.95232456
74molting cycle (GO:0042303)2.93812448
75hair cycle (GO:0042633)2.93812448
76growth hormone receptor signaling pathway (GO:0060396)2.92753174
77regulation of cholesterol homeostasis (GO:2000188)2.90155348
78detection of bacterium (GO:0016045)2.89685395
79regulation of podosome assembly (GO:0071801)2.89145878
80modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87885471
81positive regulation by organism of defense response of other organism involved in symbiotic interact2.87885471
82modulation by symbiont of host immune response (GO:0052553)2.87885471
83positive regulation by symbiont of host defense response (GO:0052509)2.87885471
84modulation by symbiont of host defense response (GO:0052031)2.87885471
85modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87885471
86positive regulation of p38MAPK cascade (GO:1900745)2.87798688
87NIK/NF-kappaB signaling (GO:0038061)2.87757643
88calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.86504082
89* digestive system process (GO:0022600)2.86172847
90immunoglobulin mediated immune response (GO:0016064)2.85546533
91positive regulation of insulin secretion (GO:0032024)2.85148280
92water homeostasis (GO:0030104)2.84354135
93excretion (GO:0007588)2.83852218
94GDP-mannose metabolic process (GO:0019673)2.83272179
95pyrimidine ribonucleoside catabolic process (GO:0046133)2.82264691
96phosphate ion transport (GO:0006817)2.81938666
97nucleotide-sugar biosynthetic process (GO:0009226)2.81808096
98positive regulation of gamma-delta T cell activation (GO:0046645)2.79511925
99maintenance of gastrointestinal epithelium (GO:0030277)2.78292207
100* negative regulation of keratinocyte proliferation (GO:0010839)2.78071085
101O-glycan processing (GO:0016266)2.77586596
102transcytosis (GO:0045056)2.73771416
103positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.73083552
104lipopolysaccharide-mediated signaling pathway (GO:0031663)2.71911366
105membrane lipid catabolic process (GO:0046466)2.69841047
106transepithelial transport (GO:0070633)2.69490198
107regulation of integrin activation (GO:0033623)2.68844192
108sphingolipid catabolic process (GO:0030149)2.68720263
109sulfur compound transport (GO:0072348)2.66951428
110regulation of mononuclear cell migration (GO:0071675)2.66780360
111regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.66341365
112regulation of nuclease activity (GO:0032069)2.66096936
113digestion (GO:0007586)2.65356640
114* cellular response to vitamin (GO:0071295)2.64899276
115eosinophil chemotaxis (GO:0048245)2.63666777
116tricarboxylic acid metabolic process (GO:0072350)2.61562344
117endoplasmic reticulum unfolded protein response (GO:0030968)2.61313312
118membrane repolarization during action potential (GO:0086011)2.60767496
119sphingoid metabolic process (GO:0046519)2.60277972
120vesicle coating (GO:0006901)2.59489220
121oligosaccharide catabolic process (GO:0009313)2.59266857
122cellular extravasation (GO:0045123)2.59225221
123granulocyte activation (GO:0036230)2.58401979
124modified amino acid transport (GO:0072337)2.57830563
125negative regulation of glycoprotein biosynthetic process (GO:0010561)2.57488745
126regulation of glucocorticoid metabolic process (GO:0031943)2.56691708
127positive regulation of chemokine biosynthetic process (GO:0045080)2.56625469
128regulation of antigen processing and presentation (GO:0002577)2.55716794
129dendritic cell chemotaxis (GO:0002407)2.55400755
130protein localization to endosome (GO:0036010)2.54882472
131nucleotide-sugar metabolic process (GO:0009225)2.54825940
132negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54581144
133negative regulation of cell killing (GO:0031342)2.54581144
134interferon-gamma-mediated signaling pathway (GO:0060333)2.54251787
135neutrophil activation (GO:0042119)2.53853140
136sphingosine metabolic process (GO:0006670)2.53820844
137fucose metabolic process (GO:0006004)2.53804831
138L-alpha-amino acid transmembrane transport (GO:1902475)2.53741563
139detection of external biotic stimulus (GO:0098581)2.51592295
140toxin metabolic process (GO:0009404)2.51329431
141cellular response to unfolded protein (GO:0034620)2.51310583
142glycoside metabolic process (GO:0016137)2.50975622
143positive regulation of antigen processing and presentation (GO:0002579)2.50634100
144* regulation of apoptotic process involved in morphogenesis (GO:1902337)2.50492451
145regulation of interferon-beta biosynthetic process (GO:0045357)2.49998817
146gland morphogenesis (GO:0022612)2.47685052
147germinal center formation (GO:0002467)2.47684064
148keratinization (GO:0031424)2.47626035
149cellular response to growth hormone stimulus (GO:0071378)2.47254591
150T-helper 1 type immune response (GO:0042088)2.46976022
151regulation of Golgi to plasma membrane protein transport (GO:0042996)2.46392195
152regulation of transforming growth factor beta1 production (GO:0032908)2.46295830
153positive regulation of leukocyte degranulation (GO:0043302)2.46187816
154regulation of monocyte chemotaxis (GO:0090025)2.45141482
155regulation of T-helper 2 cell differentiation (GO:0045628)2.43896387
156* regulation of vitamin D biosynthetic process (GO:0060556)2.41741136
157fat-soluble vitamin biosynthetic process (GO:0042362)2.41358154
158interferon-gamma secretion (GO:0072643)2.40069264
159regulation of leukocyte degranulation (GO:0043300)2.37712699
160regulation of mast cell degranulation (GO:0043304)2.37698561
161skin morphogenesis (GO:0043589)2.36548482
162regulation of membrane protein ectodomain proteolysis (GO:0051043)2.35921814
163response to type I interferon (GO:0034340)2.32863153
164eosinophil migration (GO:0072677)2.32297828
165cellular response to type I interferon (GO:0071357)2.31957523
166type I interferon signaling pathway (GO:0060337)2.31957523
167regulation of T-helper 1 cell differentiation (GO:0045625)2.31826971
168detection of molecule of bacterial origin (GO:0032490)2.30543785
169dendritic cell migration (GO:0036336)2.30363446
170positive regulation of type 2 immune response (GO:0002830)2.29914105
171regulation of extracellular matrix disassembly (GO:0010715)2.27897429
172barbed-end actin filament capping (GO:0051016)2.27793251
173regulation of gamma-delta T cell activation (GO:0046643)2.26957225
174myeloid dendritic cell differentiation (GO:0043011)2.24164709
175positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.20934663
176regulation of regulatory T cell differentiation (GO:0045589)2.18293024
177regulation of macrophage chemotaxis (GO:0010758)2.17978836
178negative regulation of erythrocyte differentiation (GO:0045647)2.16748653
179negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.16420716
180detection of biotic stimulus (GO:0009595)2.15524932
181regulation of guanylate cyclase activity (GO:0031282)2.14976442
182mannose metabolic process (GO:0006013)2.14541531
183pinocytosis (GO:0006907)2.13416918
184defense response to protozoan (GO:0042832)2.13277027
185thrombin receptor signaling pathway (GO:0070493)2.12479162
186regulation of chemokine biosynthetic process (GO:0045073)2.11878774
187response to protozoan (GO:0001562)2.10460458
188positive regulation of mast cell activation (GO:0033005)2.10456509
189regulation of viral release from host cell (GO:1902186)2.10324180
190cyclooxygenase pathway (GO:0019371)2.10104156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human9.01944864
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.62731499
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.45820548
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.34782139
5SOX2_27498859_Chip-Seq_STOMACH_Mouse3.19848349
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.11099077
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.93233511
8STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.88803180
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80340166
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65659141
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.62125014
12GATA4_25053715_ChIP-Seq_YYC3_Human2.59284226
13SOX2_20726797_ChIP-Seq_SW620_Human2.59211572
14GATA6_25053715_ChIP-Seq_YYC3_Human2.45804739
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.37244124
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36063794
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35592308
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31472028
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30607581
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28222503
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28132883
22FOXO3_23340844_ChIP-Seq_DLD1_Human2.22881003
23* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.21672417
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.18845635
25P63_26484246_Chip-Seq_KERATINOCYTES_Human2.16611557
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13288575
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09973483
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02844973
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96240391
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92851252
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92655049
32RACK7_27058665_Chip-Seq_MCF-7_Human1.85244672
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84617448
34VDR_24763502_ChIP-Seq_THP-1_Human1.83113822
35GATA1_22025678_ChIP-Seq_K562_Human1.79058371
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75602245
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.72605218
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.71767893
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69279800
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69045558
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66856272
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66131879
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65755981
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64037911
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.63528581
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63320539
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60263933
48GATA3_24758297_ChIP-Seq_MCF-7_Human1.57523209
49VDR_21846776_ChIP-Seq_THP-1_Human1.56888289
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55717404
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55438106
52* RUNX1_27514584_Chip-Seq_MCF-7_Human1.54069331
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53206158
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53177088
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50533129
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.50280202
57KLF5_25053715_ChIP-Seq_YYC3_Human1.50131851
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49546363
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46656982
60* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46214692
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45928844
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44847733
63CLOCK_20551151_ChIP-Seq_293T_Human1.44633970
64* SPI1_23127762_ChIP-Seq_K562_Human1.43906709
65ATF3_27146783_Chip-Seq_COLON_Human1.42523425
66* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41833021
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41006568
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41006568
69VDR_24787735_ChIP-Seq_THP-1_Human1.39640622
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38128414
71* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38100077
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37186223
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35932296
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33953815
75SPI1_23547873_ChIP-Seq_NB4_Human1.33583726
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.33546504
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.32034213
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31876109
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29500684
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28190604
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.27789936
82* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27142588
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26770928
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25374508
85LXR_22292898_ChIP-Seq_THP-1_Human1.25288536
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24784223
87* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23223426
88TP63_22573176_ChIP-Seq_HFKS_Human1.22150430
89ZNF263_19887448_ChIP-Seq_K562_Human1.20953589
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.18106483
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17163164
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17163164
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17163164
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17093949
95GATA1_19941826_ChIP-Seq_K562_Human1.16920158
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.16156340
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15951933
98* MAF_26560356_Chip-Seq_TH1_Human1.15166502
99* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12675389
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11908333
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11189356
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09568332
103FOXA1_25552417_ChIP-Seq_VCAP_Human1.08183503
104* TP63_23658742_ChIP-Seq_EP156T_Human1.08158359
105GATA1_19941827_ChIP-Seq_MEL_Mouse1.08101032
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06141800
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05603061
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05283216
109RUNX_20019798_ChIP-Seq_JUKART_Human1.04037852
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03303793
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02847687
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02718953
113MYB_26560356_Chip-Seq_TH2_Human1.02400131
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02242909
115* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01916605
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00286682
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00070333
118CJUN_26792858_Chip-Seq_BT549_Human0.99229764
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98232299
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97412469
121EGR1_19374776_ChIP-ChIP_THP-1_Human0.96458603
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95724275
123* BCOR_27268052_Chip-Seq_Bcells_Human0.95519790
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95509663
125CREB1_26743006_Chip-Seq_LNCaP_Human0.92016384
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91892566
127RXR_22108803_ChIP-Seq_LS180_Human0.89235606
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87420822
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86191223
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85142115
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84385104
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82513635
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82496272
134GATA2_19941826_ChIP-Seq_K562_Human0.79598613
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79162244
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79069659
137VDR_22108803_ChIP-Seq_LS180_Human0.78517884
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78206005
139* UBF1/2_26484160_Chip-Seq_HMECs_Human0.77882118
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.77297213
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.77297213
142ERG_20517297_ChIP-Seq_VCAP_Human0.75021646
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.74789987
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.72862470
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72813981
146IRF8_22096565_ChIP-ChIP_GC-B_Human0.71005792
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.70300077
148* HNF4A_19822575_ChIP-Seq_HepG2_Human0.69642977
149TCF7_22412390_ChIP-Seq_EML_Mouse0.69049214
150KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68854578
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68538624
152JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.67812167
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67016915
154GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.66951166
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.66391719
156* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.66156731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.39648003
2MP0002877_abnormal_melanocyte_morpholog3.97915101
3MP0010234_abnormal_vibrissa_follicle3.87973929
4MP0003283_abnormal_digestive_organ3.65835144
5MP0004264_abnormal_extraembryonic_tissu3.52409893
6MP0005360_urolithiasis3.49512467
7MP0002796_impaired_skin_barrier2.87389494
8MP0003436_decreased_susceptibility_to2.82517621
9MP0009840_abnormal_foam_cell2.69713034
10MP0003195_calcinosis2.62462372
11MP0003724_increased_susceptibility_to2.53146363
12MP0001835_abnormal_antigen_presentation2.50642515
13MP0002254_reproductive_system_inflammat2.50302369
14MP0002138_abnormal_hepatobiliary_system2.44902775
15MP0003303_peritoneal_inflammation2.44071795
16MP0000462_abnormal_digestive_system2.33477247
17MP0005058_abnormal_lysosome_morphology2.27785422
18MP0002148_abnormal_hypersensitivity_rea2.27581911
19MP0009785_altered_susceptibility_to2.27248214
20MP0003183_abnormal_peptide_metabolism2.19868135
21MP0003705_abnormal_hypodermis_morpholog2.17281948
22* MP0002098_abnormal_vibrissa_morphology2.13993619
23MP0003866_abnormal_defecation2.13410655
24* MP0009643_abnormal_urine_homeostasis2.10742289
25MP0002693_abnormal_pancreas_physiology2.10425681
26MP0000013_abnormal_adipose_tissue2.09455396
27* MP0001765_abnormal_ion_homeostasis2.09418766
28MP0005387_immune_system_phenotype2.08999425
29MP0001790_abnormal_immune_system2.08999425
30MP0006082_CNS_inflammation1.99676465
31MP0009780_abnormal_chondrocyte_physiolo1.96386278
32MP0003191_abnormal_cellular_cholesterol1.95671793
33* MP0001666_abnormal_nutrient_absorption1.95259196
34MP0000579_abnormal_nail_morphology1.89487979
35MP0001944_abnormal_pancreas_morphology1.88307669
36* MP0005000_abnormal_immune_tolerance1.87611257
37* MP0005025_abnormal_response_to1.85823273
38* MP0002419_abnormal_innate_immunity1.83347967
39MP0001533_abnormal_skeleton_physiology1.81068240
40* MP0000678_abnormal_parathyroid_gland1.78873227
41MP0005671_abnormal_response_to1.78440641
42* MP0004019_abnormal_vitamin_homeostasis1.73610173
43MP0005451_abnormal_body_composition1.73278890
44MP0000685_abnormal_immune_system1.72586481
45MP0003252_abnormal_bile_duct1.69340150
46MP0010352_gastrointestinal_tract_polyps1.68354158
47MP0005501_abnormal_skin_physiology1.67168055
48MP0005220_abnormal_exocrine_pancreas1.66521624
49MP0002060_abnormal_skin_morphology1.65093441
50MP0010386_abnormal_urinary_bladder1.60834744
51MP0000538_abnormal_urinary_bladder1.59669996
52MP0002909_abnormal_adrenal_gland1.59281959
53* MP0002452_abnormal_antigen_presenting1.57652016
54MP0000613_abnormal_salivary_gland1.57191063
55MP0001800_abnormal_humoral_immune1.56031665
56MP0006054_spinal_hemorrhage1.54667040
57* MP0001845_abnormal_inflammatory_respons1.53010591
58MP0005166_decreased_susceptibility_to1.52716844
59* MP0001216_abnormal_epidermal_layer1.51090684
60* MP0002723_abnormal_immune_serum1.48865275
61MP0005257_abnormal_intraocular_pressure1.48171091
62MP0003941_abnormal_skin_development1.45761784
63MP0005275_abnormal_skin_tensile1.44080415
64MP0003448_altered_tumor_morphology1.41801251
65* MP0002896_abnormal_bone_mineralization1.41166889
66MP0005464_abnormal_platelet_physiology1.40219169
67MP0009764_decreased_sensitivity_to1.39879203
68MP0002998_abnormal_bone_remodeling1.37902918
69* MP0005636_abnormal_mineral_homeostasis1.37250339
70* MP0003300_gastrointestinal_ulcer1.36627391
71MP0005023_abnormal_wound_healing1.35697126
72MP0002139_abnormal_hepatobiliary_system1.35515468
73MP0002234_abnormal_pharynx_morphology1.35451552
74MP0001881_abnormal_mammary_gland1.35175755
75MP0000858_altered_metastatic_potential1.34465851
76MP0008438_abnormal_cutaneous_collagen1.34421734
77MP0001873_stomach_inflammation1.32985451
78MP0001958_emphysema1.32685547
79MP0005381_digestive/alimentary_phenotyp1.31308925
80* MP0001819_abnormal_immune_cell1.29603111
81MP0000467_abnormal_esophagus_morphology1.29150714
82* MP0002420_abnormal_adaptive_immunity1.28461973
83MP0003075_altered_response_to1.27600044
84MP0005409_darkened_coat_color1.26828834
85MP0005379_endocrine/exocrine_gland_phen1.26630723
86MP0003453_abnormal_keratinocyte_physiol1.25580864
87MP0000343_altered_response_to1.25228315
88MP0008004_abnormal_stomach_pH1.24894072
89MP0003566_abnormal_cell_adhesion1.24669035
90MP0009379_abnormal_foot_pigmentation1.23318747
91MP0003172_abnormal_lysosome_physiology1.21508562
92MP0005377_hearing/vestibular/ear_phenot1.21168492
93MP0003878_abnormal_ear_physiology1.21168492
94* MP0001756_abnormal_urination1.20531565
95* MP0010155_abnormal_intestine_physiology1.20042631
96* MP0000377_abnormal_hair_follicle1.20023729
97* MP0008469_abnormal_protein_level1.19991125
98MP0000465_gastrointestinal_hemorrhage1.19977055
99MP0000003_abnormal_adipose_tissue1.18823865
100MP0010678_abnormal_skin_adnexa1.17939474
101MP0000537_abnormal_urethra_morphology1.16991775
102MP0000604_amyloidosis1.16803440
103MP0008961_abnormal_basal_metabolism1.16757049
104MP0000762_abnormal_tongue_morphology1.15972589
105MP0004782_abnormal_surfactant_physiolog1.15226314
106MP0001664_abnormal_digestion1.14904723
107MP0001663_abnormal_digestive_system1.14141879
108MP0001270_distended_abdomen1.13443107
109MP0003806_abnormal_nucleotide_metabolis1.11848516
110MP0000427_abnormal_hair_cycle1.10168911
111MP0005085_abnormal_gallbladder_physiolo1.09220017
112* MP0002136_abnormal_kidney_physiology1.07651206
113* MP0009333_abnormal_splenocyte_physiolog1.05562067
114MP0005390_skeleton_phenotype1.05229704
115MP0008260_abnormal_autophagy1.05108828
116MP0002405_respiratory_system_inflammati1.03640852
117* MP0002078_abnormal_glucose_homeostasis1.01603221
118MP0003828_pulmonary_edema1.01568764
119MP0000516_abnormal_urinary_system1.01340619
120MP0005367_renal/urinary_system_phenotyp1.01340619
121MP0003045_fibrosis1.00914512
122MP0003091_abnormal_cell_migration1.00882353
123* MP0000477_abnormal_intestine_morphology1.00744962
124MP0005310_abnormal_salivary_gland1.00545443
125MP0003279_aneurysm1.00370515
126MP0005332_abnormal_amino_acid0.98079748
127MP0004381_abnormal_hair_follicle0.96484397
128MP0002166_altered_tumor_susceptibility0.96144341
129MP0004858_abnormal_nervous_system0.95784026
130MP0009384_cardiac_valve_regurgitation0.95661861
131* MP0004947_skin_inflammation0.94198359
132MP0004510_myositis0.93823155
133MP0005164_abnormal_response_to0.93203356
134MP0001346_abnormal_lacrimal_gland0.92305587
135* MP0000490_abnormal_crypts_of0.92117799
136MP0008875_abnormal_xenobiotic_pharmacok0.91672365
137MP0001542_abnormal_bone_strength0.91373463
138MP0000383_abnormal_hair_follicle0.90158348
139MP0010771_integument_phenotype0.88221891
140* MP0000716_abnormal_immune_system0.87635128
141MP0003763_abnormal_thymus_physiology0.87189217
142MP0002928_abnormal_bile_duct0.86690297
143MP0005084_abnormal_gallbladder_morpholo0.86356657
144MP0005365_abnormal_bile_salt0.86338263
145MP0000647_abnormal_sebaceous_gland0.85798640
146MP0002009_preneoplasia0.84308674
147MP0002006_tumorigenesis0.83647843
148MP0000470_abnormal_stomach_morphology0.79087924
149* MP0000367_abnormal_coat/_hair0.77574245
150* MP0000163_abnormal_cartilage_morphology0.76678704
151* MP0003795_abnormal_bone_structure0.75296833
152* MP0001191_abnormal_skin_condition0.74721017
153MP0005375_adipose_tissue_phenotype0.74358324
154MP0009931_abnormal_skin_appearance0.74073924
155MP0001348_abnormal_lacrimal_gland0.69330411
156MP0005248_abnormal_Harderian_gland0.67581134
157MP0000627_abnormal_mammary_gland0.66898796
158* MP0003953_abnormal_hormone_level0.66300780
159MP0004185_abnormal_adipocyte_glucose0.63723683
160MP0003868_abnormal_feces_composition0.63511936

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.60414811
2Abnormality of chloride homeostasis (HP:0011422)4.87480832
3Hyperinsulinemic hypoglycemia (HP:0000825)4.76868150
4Metabolic alkalosis (HP:0200114)4.49446610
5Abnormality of renin-angiotensin system (HP:0000847)4.17417771
6Hypoglycemic coma (HP:0001325)4.09020315
7Eczematoid dermatitis (HP:0000976)4.05978196
8Hypoglycemic seizures (HP:0002173)3.95356858
9Hypokalemic alkalosis (HP:0001949)3.91754778
10Increased circulating renin level (HP:0000848)3.91435676
11Gout (HP:0001997)3.89991416
12Hypokalemia (HP:0002900)3.82765654
13Abnormality of liposaccharide metabolism (HP:0010968)3.74170178
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.74170178
15Abnormality of glycolipid metabolism (HP:0010969)3.74170178
16Ketoacidosis (HP:0001993)3.71687326
17Abnormality of macrophages (HP:0004311)3.64457048
18Generalized aminoaciduria (HP:0002909)3.63810988
19Decreased circulating renin level (HP:0003351)3.48334567
20Right ventricular cardiomyopathy (HP:0011663)3.47471533
21Abnormality of purine metabolism (HP:0004352)3.39666931
22Insulin-resistant diabetes mellitus (HP:0000831)3.32583376
23Hyperphosphaturia (HP:0003109)3.24932539
24Systemic lupus erythematosus (HP:0002725)3.19683793
25Recurrent bacterial skin infections (HP:0005406)3.19450778
26Abnormal pancreas size (HP:0012094)3.15683358
27Hyperaldosteronism (HP:0000859)3.15648141
28* Symptomatic seizures (HP:0011145)3.08232691
29Hyperglycemia (HP:0003074)3.07695445
30Ileus (HP:0002595)3.06009071
31Hypomagnesemia (HP:0002917)3.03520675
32Abnormality of potassium homeostasis (HP:0011042)2.99736749
33Fragile nails (HP:0001808)2.98142360
34Abnormality of magnesium homeostasis (HP:0004921)2.97313747
35Tetany (HP:0001281)2.96981960
36Chronic diarrhea (HP:0002028)2.96560081
37Woolly hair (HP:0002224)2.95553693
38Abnormality of urine glucose concentration (HP:0011016)2.94560051
39Glycosuria (HP:0003076)2.94560051
40Recurrent abscess formation (HP:0002722)2.93972142
41Orchitis (HP:0100796)2.93236772
42Abnormality of renal excretion (HP:0011036)2.93157227
43Late onset (HP:0003584)2.92901284
44Myositis (HP:0100614)2.92718146
45Alkalosis (HP:0001948)2.91148667
46Villous atrophy (HP:0011473)2.89521322
47Abnormality of small intestinal villus morphology (HP:0011472)2.89521322
48Abnormal urine output (HP:0012590)2.87117920
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.86821612
50Increased cerebral lipofuscin (HP:0011813)2.85630668
51Alopecia of scalp (HP:0002293)2.84676303
52Polyuria (HP:0000103)2.84586976
53Pili torti (HP:0003777)2.84492737
54Petechiae (HP:0000967)2.83543333
55Malnutrition (HP:0004395)2.83340128
56Abnormal urine phosphate concentration (HP:0012599)2.79944260
57Plantar hyperkeratosis (HP:0007556)2.78824150
58Abnormality of the distal phalanges of the toes (HP:0010182)2.76959525
59* Abdominal distention (HP:0003270)2.75903139
60Dehydration (HP:0001944)2.74065160
61Thick nail (HP:0001805)2.73856555
62Abnormality of nail color (HP:0100643)2.71548025
63Proximal tubulopathy (HP:0000114)2.66875778
64Milia (HP:0001056)2.64386937
65Congenital sensorineural hearing impairment (HP:0008527)2.63220433
66Increased purine levels (HP:0004368)2.61960696
67Hyperuricemia (HP:0002149)2.61960696
68Elevated erythrocyte sedimentation rate (HP:0003565)2.57068505
69Urinary glycosaminoglycan excretion (HP:0003541)2.56541920
70Mucopolysacchariduria (HP:0008155)2.56541920
71Conjugated hyperbilirubinemia (HP:0002908)2.55277095
72Abnormal hemoglobin (HP:0011902)2.53496784
73Pustule (HP:0200039)2.52680241
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.52475494
75* Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.49991843
76Loss of speech (HP:0002371)2.49316043
77Unilateral renal agenesis (HP:0000122)2.48279767
78Gingivitis (HP:0000230)2.47416941
79Renal salt wasting (HP:0000127)2.41306691
80Hydroxyprolinuria (HP:0003080)2.39913985
81Abnormality of proline metabolism (HP:0010907)2.39913985
82Atrophic scars (HP:0001075)2.38463908
83Insulin resistance (HP:0000855)2.36911248
84* Abnormality of calcium-phosphate metabolism (HP:0100530)2.36524573
85Cheilitis (HP:0100825)2.35866101
86Retrobulbar optic neuritis (HP:0100654)2.33746138
87Optic neuritis (HP:0100653)2.33746138
88Flat acetabular roof (HP:0003180)2.33270364
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30183044
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30183044
91Abnormality of polysaccharide metabolism (HP:0011012)2.30183044
92* Hypophosphatemia (HP:0002148)2.28135883
93Vacuolated lymphocytes (HP:0001922)2.27316549
94Adrenal overactivity (HP:0002717)2.25096287
95Osteolytic defects of the hand bones (HP:0009699)2.24931857
96Osteolytic defects of the phalanges of the hand (HP:0009771)2.24931857
97Increased IgE level (HP:0003212)2.23038118
98Abnormal drinking behavior (HP:0030082)2.21907704
99Polydipsia (HP:0001959)2.21907704
100Mildly elevated creatine phosphokinase (HP:0008180)2.21608410
101Cervical subluxation (HP:0003308)2.20939909
102Hypotrichosis (HP:0001006)2.20802362
103Onycholysis (HP:0001806)2.20405503
104Abnormal blistering of the skin (HP:0008066)2.18431852
105Hypercalciuria (HP:0002150)2.18224195
106Stomatitis (HP:0010280)2.17850623
107Abnormal hair laboratory examination (HP:0003328)2.17446131
108Neonatal short-limb short stature (HP:0008921)2.15451703
109Vasculitis (HP:0002633)2.14653905
110Interstitial pulmonary disease (HP:0006530)2.13564009
111Pulmonary infiltrates (HP:0002113)2.10626930
112Abnormality of the gastric mucosa (HP:0004295)2.10361672
113Urticaria (HP:0001025)2.10134726
114Dysostosis multiplex (HP:0000943)2.09281193
115Spontaneous hematomas (HP:0007420)2.07876336
116Hemoptysis (HP:0002105)2.07815287
117Abnormal biliary tract morphology (HP:0012440)2.06446627
118Ventricular fibrillation (HP:0001663)2.03583967
119Premature rupture of membranes (HP:0001788)2.02979517
120Hyperphosphatemia (HP:0002905)2.02426484
121Purpura (HP:0000979)2.02270494
122Vertebral compression fractures (HP:0002953)2.01751377
123Autoimmune thrombocytopenia (HP:0001973)2.01733605
124Recurrent skin infections (HP:0001581)2.01132779
125Emphysema (HP:0002097)2.01121981
126Nail dystrophy (HP:0008404)2.00895661
127Ketosis (HP:0001946)2.00869531
128Thoracolumbar scoliosis (HP:0002944)2.00812178
129Palmoplantar hyperkeratosis (HP:0000972)2.00771822
130Abnormality of endocrine pancreas physiology (HP:0012093)2.00320003
131Abnormality of the pancreatic islet cells (HP:0006476)2.00320003
132Osteomalacia (HP:0002749)2.00198878
133Recurrent fungal infections (HP:0002841)2.00189403
134Peritonitis (HP:0002586)2.00067003
135Axonal loss (HP:0003447)1.99644553
136Amyloidosis (HP:0011034)1.98004081
137Curly hair (HP:0002212)1.95796636
138Fragile skin (HP:0001030)1.94365476
139Abnormal tarsal ossification (HP:0008369)1.94157601
140* Hyperparathyroidism (HP:0000843)1.93360402
141Abnormality of nucleobase metabolism (HP:0010932)1.92607115
142Pancreatic islet-cell hyperplasia (HP:0004510)1.91251721
143Ridged nail (HP:0001807)1.90563900
144Gastrointestinal infarctions (HP:0005244)1.90365181
145Hypergammaglobulinemia (HP:0010702)1.90292382
146Obstructive lung disease (HP:0006536)1.89505457
147Chronic obstructive pulmonary disease (HP:0006510)1.89505457
148Segmental peripheral demyelination/remyelination (HP:0003481)1.89443855
149Exocrine pancreatic insufficiency (HP:0001738)1.89295249
150Mediastinal lymphadenopathy (HP:0100721)1.88656275
151Hypotension (HP:0002615)1.88137935
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87020362
153* Bone pain (HP:0002653)1.86606310
154Hyperglycinuria (HP:0003108)1.86148462
155Spondylolisthesis (HP:0003302)1.86072432
156Palmar hyperkeratosis (HP:0010765)1.85086529
157* Nephrolithiasis (HP:0000787)1.84684425
158Keratoconjunctivitis sicca (HP:0001097)1.83490528
159Myocardial infarction (HP:0001658)1.80706323
160Follicular hyperkeratosis (HP:0007502)1.79189259
161Gingival bleeding (HP:0000225)1.79059203
162Skin ulcer (HP:0200042)1.76434226
163Increased serum ferritin (HP:0003281)1.75492562
164Gastrointestinal stroma tumor (HP:0100723)1.75031940
165Nephritis (HP:0000123)1.68489374
166Hematochezia (HP:0002573)1.67829641
167Glomerulonephritis (HP:0000099)1.67789833
168Epistaxis (HP:0000421)1.66694604
169Gangrene (HP:0100758)1.66398685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.20873490
2ERN13.94551209
3WNK43.91721683
4MST1R3.69432052
5FRK3.51687327
6PASK3.13783196
7MAP3K22.87325743
8MAPK152.47754080
9RIPK42.41077217
10WNK32.32179869
11ACVR1B2.25094226
12MST42.05904150
13TYK22.05092165
14HIPK22.03230744
15EPHA31.93632861
16MAP2K21.89552428
17MET1.87428174
18PTK61.87112071
19IRAK31.85586520
20EPHB21.85107858
21PRPF4B1.84579087
22TAOK31.77975273
23MAP4K11.77569623
24PIK3CA1.69669192
25MAP3K131.66066452
26BLK1.64744595
27CDK121.62236304
28IRAK41.60419599
29PRKG21.58817036
30LMTK21.53949625
31MAP3K31.53007239
32RIPK11.49994588
33EPHB11.49914586
34PRKD31.46901503
35FER1.46220072
36NME11.43998541
37MAP3K11.41334465
38OXSR11.41187228
39EPHA21.40387560
40PTK21.40351921
41FLT31.34148078
42PDGFRA1.32146677
43IKBKB1.27540952
44TAOK11.27170272
45STK241.23456173
46IKBKE1.22836897
47TXK1.21766351
48NUAK11.18504434
49LATS11.16007353
50FGFR41.14507245
51PIK3CG1.12210563
52MYLK1.11896376
53TAOK21.09253947
54WNK11.08998195
55SIK31.08309540
56TRIB31.06699811
57DYRK1B1.06113279
58PIM21.04761334
59TESK21.03915186
60DDR21.00795382
61IRAK10.98923988
62MAP2K30.96612322
63STK390.95681256
64GRK70.95217571
65CSF1R0.94911106
66FGFR30.94331733
67MAP3K110.93888764
68BMPR20.93030391
69FGR0.89727283
70NTRK10.89334145
71MATK0.86051081
72KSR20.84498276
73SMG10.82566477
74KIT0.81829270
75RPS6KA20.80461037
76GRK60.78894221
77SIK10.78824199
78MAPKAPK30.78647949
79CDC42BPA0.78332182
80PDPK10.77460271
81MAP3K60.76486396
82MAP3K120.75976195
83STK38L0.75856576
84BTK0.75441071
85ABL20.75326924
86MAP2K60.75264076
87GRK10.73427121
88CHUK0.72818722
89HCK0.70332281
90SYK0.70241176
91NLK0.67728432
92ARAF0.67301587
93JAK30.65433948
94IRAK20.62118143
95JAK20.62022090
96NEK90.61715510
97PRKCI0.61573034
98LYN0.61360003
99PRKD20.60962454
100TESK10.57792357
101LRRK20.57599153
102TGFBR20.55962793
103ITK0.54853321
104SCYL20.54604703
105MAPK70.54285258
106RPS6KL10.53542002
107RPS6KC10.53542002
108GSK3A0.52591991
109ADRBK20.52458214
110BCKDK0.52093886
111LCK0.51861479
112PDK10.46259379
113MAP3K70.45395556
114PDK20.44426474
115PRKAA20.43036361
116PAK30.42981976
117PRKAA10.40832311
118RET0.39534905
119CSK0.39027597
120MAP2K10.38555120
121ERBB20.38252712
122MAP3K100.37221335
123PKN20.36842386
124NME20.36460961
125CDK90.35948952
126PDGFRB0.35410569
127MAPK110.34343354
128TBK10.33576765
129AKT30.31514531
130BMX0.31384918
131GRK50.30895944
132IGF1R0.30632824
133CSNK1A10.30626063
134BCR0.30614972
135JAK10.30195385
136MAP3K140.30108339
137STK100.29790928
138PRKCH0.29515170
139PAK40.28678654
140PRKCD0.28261353
141TRPM70.27211343
142MAPKAPK20.26556062
143ZAP700.26413989
144PRKCE0.25596816
145BMPR1B0.23249311
146PRKD10.21265999

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.11198631
2Sulfur metabolism_Homo sapiens_hsa009204.42256232
3Protein export_Homo sapiens_hsa030602.55694816
4Galactose metabolism_Homo sapiens_hsa000522.42664058
5Fat digestion and absorption_Homo sapiens_hsa049752.32846964
6Carbohydrate digestion and absorption_Homo sapiens_hsa049732.31930552
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27769696
8Protein digestion and absorption_Homo sapiens_hsa049742.23954493
9Staphylococcus aureus infection_Homo sapiens_hsa051502.16902186
10Allograft rejection_Homo sapiens_hsa053302.06095140
11Leishmaniasis_Homo sapiens_hsa051402.03334626
12Asthma_Homo sapiens_hsa053102.02408599
13* Mineral absorption_Homo sapiens_hsa049781.98021672
14Graft-versus-host disease_Homo sapiens_hsa053321.94226369
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.92090826
16Folate biosynthesis_Homo sapiens_hsa007901.87277002
17Osteoclast differentiation_Homo sapiens_hsa043801.85960145
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.80425003
19Autoimmune thyroid disease_Homo sapiens_hsa053201.78879492
20Vitamin digestion and absorption_Homo sapiens_hsa049771.73059961
21Renin-angiotensin system_Homo sapiens_hsa046141.71809101
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69930076
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.65310137
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64894352
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64784072
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.63400648
27Caffeine metabolism_Homo sapiens_hsa002321.61128110
28Starch and sucrose metabolism_Homo sapiens_hsa005001.58464759
29Tryptophan metabolism_Homo sapiens_hsa003801.58381080
30Rheumatoid arthritis_Homo sapiens_hsa053231.53819249
31* Tuberculosis_Homo sapiens_hsa051521.53395759
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49451463
33Fructose and mannose metabolism_Homo sapiens_hsa000511.48800638
34Insulin secretion_Homo sapiens_hsa049111.45301206
35Other glycan degradation_Homo sapiens_hsa005111.44411536
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.39405101
37Histidine metabolism_Homo sapiens_hsa003401.38659155
38Selenocompound metabolism_Homo sapiens_hsa004501.36637871
39Sphingolipid metabolism_Homo sapiens_hsa006001.35224897
40Hematopoietic cell lineage_Homo sapiens_hsa046401.33461228
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28206632
42Vibrio cholerae infection_Homo sapiens_hsa051101.26061770
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25780599
44Antigen processing and presentation_Homo sapiens_hsa046121.23048799
45Malaria_Homo sapiens_hsa051441.22165503
46Influenza A_Homo sapiens_hsa051641.21933857
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19368486
48Bile secretion_Homo sapiens_hsa049761.18783656
49Phagosome_Homo sapiens_hsa041451.15931173
50Butanoate metabolism_Homo sapiens_hsa006501.15381392
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10862230
52Type II diabetes mellitus_Homo sapiens_hsa049301.10675001
53Bladder cancer_Homo sapiens_hsa052191.09441118
54Chemokine signaling pathway_Homo sapiens_hsa040621.07431912
55B cell receptor signaling pathway_Homo sapiens_hsa046621.06878570
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06835217
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05098469
58Linoleic acid metabolism_Homo sapiens_hsa005911.02857699
59Salmonella infection_Homo sapiens_hsa051321.02576257
60Pancreatic secretion_Homo sapiens_hsa049721.00781072
61Arachidonic acid metabolism_Homo sapiens_hsa005901.00172866
62Fatty acid degradation_Homo sapiens_hsa000710.99095847
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97506826
64N-Glycan biosynthesis_Homo sapiens_hsa005100.97037819
65Viral myocarditis_Homo sapiens_hsa054160.96304592
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.96095968
67ABC transporters_Homo sapiens_hsa020100.95536942
68Type I diabetes mellitus_Homo sapiens_hsa049400.94152449
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92257119
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90392823
71Prolactin signaling pathway_Homo sapiens_hsa049170.89757190
72Acute myeloid leukemia_Homo sapiens_hsa052210.88941671
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87254855
74Shigellosis_Homo sapiens_hsa051310.86389105
75Thyroid cancer_Homo sapiens_hsa052160.83819645
76Measles_Homo sapiens_hsa051620.83725411
77Insulin resistance_Homo sapiens_hsa049310.81283717
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80731461
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.78394465
80Lysosome_Homo sapiens_hsa041420.77811723
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75463453
82Apoptosis_Homo sapiens_hsa042100.74941148
83Thyroid hormone synthesis_Homo sapiens_hsa049180.74728480
84T cell receptor signaling pathway_Homo sapiens_hsa046600.71730937
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.71292824
86African trypanosomiasis_Homo sapiens_hsa051430.70391341
87Platelet activation_Homo sapiens_hsa046110.70230044
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68287249
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67530717
90Herpes simplex infection_Homo sapiens_hsa051680.65950766
91Glutathione metabolism_Homo sapiens_hsa004800.65938767
92Hepatitis B_Homo sapiens_hsa051610.65166682
93Lysine degradation_Homo sapiens_hsa003100.62879877
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62104763
95* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59104407
96Hepatitis C_Homo sapiens_hsa051600.57490314
97Tight junction_Homo sapiens_hsa045300.54973930
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54077577
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53903709
100VEGF signaling pathway_Homo sapiens_hsa043700.53576413
101Endocytosis_Homo sapiens_hsa041440.52587305
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50693229
103Glycerolipid metabolism_Homo sapiens_hsa005610.49397639
104Collecting duct acid secretion_Homo sapiens_hsa049660.46241196
105Peroxisome_Homo sapiens_hsa041460.46056984
106Ether lipid metabolism_Homo sapiens_hsa005650.45967020
107Pancreatic cancer_Homo sapiens_hsa052120.45865718
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43765423
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43659075
110PPAR signaling pathway_Homo sapiens_hsa033200.41901847
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41835831
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40827494
113Chronic myeloid leukemia_Homo sapiens_hsa052200.40650959
114GnRH signaling pathway_Homo sapiens_hsa049120.40590348
115ECM-receptor interaction_Homo sapiens_hsa045120.40425035
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.39318533
117Arginine and proline metabolism_Homo sapiens_hsa003300.38746694
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.37293483
119Adherens junction_Homo sapiens_hsa045200.37063985
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.36416925
121Gastric acid secretion_Homo sapiens_hsa049710.33932770
122Inositol phosphate metabolism_Homo sapiens_hsa005620.33727029
123Ribosome_Homo sapiens_hsa030100.32669802
124Pyruvate metabolism_Homo sapiens_hsa006200.32161567
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30650976
126Legionellosis_Homo sapiens_hsa051340.28626668
127Phenylalanine metabolism_Homo sapiens_hsa003600.28505739
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26123135
129beta-Alanine metabolism_Homo sapiens_hsa004100.25748233
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23810347
131Dorso-ventral axis formation_Homo sapiens_hsa043200.22967881
132Retinol metabolism_Homo sapiens_hsa008300.22698466
133Fatty acid metabolism_Homo sapiens_hsa012120.21763898
134Glucagon signaling pathway_Homo sapiens_hsa049220.21149026
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20933858
136Cocaine addiction_Homo sapiens_hsa050300.20704490
137Metabolic pathways_Homo sapiens_hsa011000.20089386
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19448769
139Chemical carcinogenesis_Homo sapiens_hsa052040.18728532
140Amoebiasis_Homo sapiens_hsa051460.16414556
141Toxoplasmosis_Homo sapiens_hsa051450.15926215
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15723210
143Circadian rhythm_Homo sapiens_hsa047100.14355319
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.14002482
145Pertussis_Homo sapiens_hsa051330.13907939
146TNF signaling pathway_Homo sapiens_hsa046680.12752995
147Prostate cancer_Homo sapiens_hsa052150.12687702
148Proteoglycans in cancer_Homo sapiens_hsa052050.12411433
149Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12317749
150Propanoate metabolism_Homo sapiens_hsa006400.12249285
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.11904643
152Endometrial cancer_Homo sapiens_hsa052130.11803664

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