VCY1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.60392102
2DNA packaging (GO:0006323)9.21945454
3sperm capacitation (GO:0048240)8.85622741
4response to pheromone (GO:0019236)8.62723565
5plasma membrane fusion (GO:0045026)8.43714006
6microtubule depolymerization (GO:0007019)8.18707688
7spermatid development (GO:0007286)8.18169049
8rRNA methylation (GO:0031167)7.96546862
9spermatid nucleus differentiation (GO:0007289)7.88484564
10single strand break repair (GO:0000012)7.86601348
11sperm-egg recognition (GO:0035036)7.84014723
12binding of sperm to zona pellucida (GO:0007339)7.55957227
13multicellular organism reproduction (GO:0032504)7.44044882
14rRNA modification (GO:0000154)7.12609637
15reproduction (GO:0000003)6.98595407
16protein polyglutamylation (GO:0018095)6.95128442
17sexual reproduction (GO:0019953)6.71799057
18phosphatidylethanolamine biosynthetic process (GO:0006646)6.46417673
19microtubule polymerization or depolymerization (GO:0031109)6.42923084
20negative regulation of inclusion body assembly (GO:0090084)6.42729148
21cell-cell recognition (GO:0009988)6.41615579
22calcium ion-dependent exocytosis (GO:0017156)6.33182585
23spermatogenesis (GO:0007283)6.29636756
24male gamete generation (GO:0048232)6.27486336
25phosphatidylethanolamine metabolic process (GO:0046337)6.05245483
26microtubule severing (GO:0051013)5.78274635
27gamete generation (GO:0007276)5.77157742
28protein targeting to Golgi (GO:0000042)5.63119372
29axonemal dynein complex assembly (GO:0070286)5.63008473
30cellular ketone body metabolic process (GO:0046950)5.58373677
31establishment of protein localization to Golgi (GO:0072600)5.36591656
32single fertilization (GO:0007338)5.17186540
33retrograde transport, vesicle recycling within Golgi (GO:0000301)5.10690426
34regulation of cilium movement (GO:0003352)5.09527112
35ketone body metabolic process (GO:1902224)4.93204343
36centriole replication (GO:0007099)4.87119129
37germ cell development (GO:0007281)4.76040983
38motile cilium assembly (GO:0044458)4.70233905
39regulation of centriole replication (GO:0046599)4.68477142
40RNA destabilization (GO:0050779)4.68120234
41multicellular organismal reproductive process (GO:0048609)4.61121332
42regulation of inclusion body assembly (GO:0090083)4.60488561
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.45265856
44centriole assembly (GO:0098534)4.44485181
45male meiosis I (GO:0007141)4.36112029
46fertilization (GO:0009566)4.35694849
47chromatin silencing (GO:0006342)4.31852973
48polyamine biosynthetic process (GO:0006596)4.27358707
49nucleus organization (GO:0006997)4.22021929
50positive regulation of Rab GTPase activity (GO:0032851)4.21459487
51regulation of Rab GTPase activity (GO:0032313)4.21459487
52cilium or flagellum-dependent cell motility (GO:0001539)4.17525290
53piRNA metabolic process (GO:0034587)4.14035798
54protein localization to Golgi apparatus (GO:0034067)4.07792681
55organic cation transport (GO:0015695)4.05804532
56negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.95525884
57regulation of transcription involved in cell fate commitment (GO:0060850)3.81559188
58seminiferous tubule development (GO:0072520)3.80424627
59cell wall macromolecule catabolic process (GO:0016998)3.78570894
60coenzyme catabolic process (GO:0009109)3.72107868
61DNA methylation involved in gamete generation (GO:0043046)3.65101624
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63128539
63epithelial cilium movement (GO:0003351)3.61655901
64cell wall macromolecule metabolic process (GO:0044036)3.57770480
65male meiosis (GO:0007140)3.56309109
66regulation of microtubule-based movement (GO:0060632)3.55554627
67gonadal mesoderm development (GO:0007506)3.53069550
68histone exchange (GO:0043486)3.50996318
69glycerol ether metabolic process (GO:0006662)3.50973877
70response to acidic pH (GO:0010447)3.48007278
71histone H3-K9 demethylation (GO:0033169)3.45675067
72meiosis I (GO:0007127)3.42370664
73cellular response to pH (GO:0071467)3.37727088
74regulation of retinoic acid receptor signaling pathway (GO:0048385)3.36297278
75negative regulation of Rho protein signal transduction (GO:0035024)3.34230790
76chaperone-mediated protein complex assembly (GO:0051131)3.23334793
77ether metabolic process (GO:0018904)3.22411578
78cilium movement (GO:0003341)3.16033667
79tooth mineralization (GO:0034505)3.10568155
80multicellular organismal development (GO:0007275)3.05160402
81somite rostral/caudal axis specification (GO:0032525)3.03417347
82multicellular organismal movement (GO:0050879)2.98854005
83musculoskeletal movement (GO:0050881)2.98854005
84DNA conformation change (GO:0071103)2.98425319
85membrane protein intracellular domain proteolysis (GO:0031293)2.98330428
86mitochondrial fission (GO:0000266)2.97517479
87homeostasis of number of cells within a tissue (GO:0048873)2.96263977
88regulation of meiosis I (GO:0060631)2.94007546
89cellular biogenic amine biosynthetic process (GO:0042401)2.92550719
90ribosome assembly (GO:0042255)2.92287240
91protein depolymerization (GO:0051261)2.91333009
92peptidyl-threonine dephosphorylation (GO:0035970)2.90568663
93nucleosome disassembly (GO:0006337)2.89754989
94protein-DNA complex disassembly (GO:0032986)2.89754989
95negative regulation of gene expression, epigenetic (GO:0045814)2.88200095
96cell recognition (GO:0008037)2.83445262
97peptidyl-proline hydroxylation (GO:0019511)2.83113793
98acrosome reaction (GO:0007340)11.8366526
99sperm motility (GO:0030317)11.3253164
100fusion of sperm to egg plasma membrane (GO:0007342)11.1519679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.01458222
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.86658692
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.31729374
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15549453
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62300185
6ERA_21632823_ChIP-Seq_H3396_Human2.39116205
7ELF1_20517297_ChIP-Seq_JURKAT_Human2.33891430
8RAC3_21632823_ChIP-Seq_H3396_Human2.17922519
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.13995842
10CBP_20019798_ChIP-Seq_JUKART_Human2.13995842
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11654148
12NANOG_20526341_ChIP-Seq_ESCs_Human2.08733762
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.02421653
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02421653
15RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.01151904
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98271908
17YY1_22570637_ChIP-Seq_MALME-3M_Human1.97719692
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.90613971
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89528470
20EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.89430228
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.87445919
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85671683
23TDRD3_21172665_ChIP-Seq_MCF-7_Human1.83129585
24BCOR_27268052_Chip-Seq_Bcells_Human1.80815182
25AUTS2_25519132_ChIP-Seq_293T-REX_Human1.79745978
26CTCF_20526341_ChIP-Seq_ESCs_Human1.78845625
27E2F1_20622854_ChIP-Seq_HELA_Human1.78508686
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.74896066
29MYC_19829295_ChIP-Seq_ESCs_Human1.72836147
30PHF8_20622854_ChIP-Seq_HELA_Human1.71501600
31RBPJ_21746931_ChIP-Seq_IB4_Human1.69873547
32SMC4_20622854_ChIP-Seq_HELA_Human1.68858268
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67596645
34CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.66673406
35TAF2_19829295_ChIP-Seq_ESCs_Human1.65170655
36BCL6_27268052_Chip-Seq_Bcells_Human1.64264280
37OCT4_20526341_ChIP-Seq_ESCs_Human1.63762429
38CTCF_27219007_Chip-Seq_Bcells_Human1.62248404
39HNFA_21074721_ChIP-Seq_CACO-2_Human1.60943261
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57445773
41P68_20966046_ChIP-Seq_HELA_Human1.57399789
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.54072002
43FUS_26573619_Chip-Seq_HEK293_Human1.53338182
44ZNF274_21170338_ChIP-Seq_K562_Hela1.53321701
45ETV1_20927104_ChIP-Seq_GIST48_Human1.51404163
46CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50857051
47P300_27268052_Chip-Seq_Bcells_Human1.49718633
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.49166140
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46870288
50TP63_22573176_ChIP-Seq_HFKS_Human1.46629555
51P53_21459846_ChIP-Seq_SAOS-2_Human1.44108920
52GATA6_21074721_ChIP-Seq_CACO-2_Human1.40376608
53PHF8_20622853_ChIP-Seq_HELA_Human1.40208284
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.37297248
55ERG_20517297_ChIP-Seq_VCAP_Human1.34687395
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34138136
57NFYB_21822215_ChIP-Seq_K562_Human1.33838451
58GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.32654890
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32603010
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31257781
61ER_23166858_ChIP-Seq_MCF-7_Human1.30245448
62VDR_22108803_ChIP-Seq_LS180_Human1.29114384
63HOXB7_26014856_ChIP-Seq_BT474_Human1.28864145
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27865678
65SA1_27219007_Chip-Seq_Bcells_Human1.26587256
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25952839
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25577116
68AR_25329375_ChIP-Seq_VCAP_Human1.24907847
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24498034
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24300856
71KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24233498
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23834823
73CEBPB_22108803_ChIP-Seq_LS180_Human1.22122672
74P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.21239625
75TBL1_22424771_ChIP-Seq_293T_Human1.18655614
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17426668
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16855723
78NCOR_22424771_ChIP-Seq_293T_Human1.15567823
79SMAD3_21741376_ChIP-Seq_ESCs_Human1.14318673
80NFYA_21822215_ChIP-Seq_K562_Human1.11570563
81RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10076273
82NANOG_19829295_ChIP-Seq_ESCs_Human1.10018825
83SOX2_19829295_ChIP-Seq_ESCs_Human1.10018825
84P300_19829295_ChIP-Seq_ESCs_Human1.08555623
85GATA3_21867929_ChIP-Seq_CD8_Mouse1.08045134
86LXR_22292898_ChIP-Seq_THP-1_Human1.07958093
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07583050
88DROSHA_22980978_ChIP-Seq_HELA_Human1.05967586
89FOXH1_21741376_ChIP-Seq_ESCs_Human1.05105934
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04993684
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02459273
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.02027929
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.01696280
94OCT4_19829295_ChIP-Seq_ESCs_Human0.99245237
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99215369
96E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98504576
97SMRT_27268052_Chip-Seq_Bcells_Human0.98069555
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.97490797
99SOX2_21211035_ChIP-Seq_LN229_Human0.97370479
100CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96249413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.96643431
2MP0005377_hearing/vestibular/ear_phenot4.65787497
3MP0003878_abnormal_ear_physiology4.65787497
4MP0003698_abnormal_male_reproductive4.59551183
5MP0001929_abnormal_gametogenesis4.23909444
6MP0003718_maternal_effect3.47888385
7MP0002161_abnormal_fertility/fecundity2.69836885
8MP0001348_abnormal_lacrimal_gland2.31848165
9MP0002210_abnormal_sex_determination2.27780766
10MP0003011_delayed_dark_adaptation2.15320485
11MP0003646_muscle_fatigue2.05959994
12MP0008877_abnormal_DNA_methylation2.04729139
13MP0000678_abnormal_parathyroid_gland2.02342408
14MP0005410_abnormal_fertilization11.9040631
15MP0001145_abnormal_male_reproductive1.85836868
16MP0000653_abnormal_sex_gland1.75067720
17MP0002132_abnormal_respiratory_system1.55366067
18MP0005395_other_phenotype1.48153319
19MP0005451_abnormal_body_composition1.46594345
20MP0005310_abnormal_salivary_gland1.37707258
21MP0005423_abnormal_somatic_nervous1.31767303
22MP0005379_endocrine/exocrine_gland_phen1.29125611
23MP0002138_abnormal_hepatobiliary_system1.26682281
24MP0001968_abnormal_touch/_nociception1.25570289
25MP0001485_abnormal_pinna_reflex1.23059396
26MP0001765_abnormal_ion_homeostasis1.18711481
27MP0004957_abnormal_blastocyst_morpholog1.14294207
28MP0005666_abnormal_adipose_tissue1.13215777
29MP0003077_abnormal_cell_cycle1.12491712
30MP0002234_abnormal_pharynx_morphology1.12085512
31MP0002282_abnormal_trachea_morphology1.08739247
32MP0001486_abnormal_startle_reflex1.07213868
33MP0004233_abnormal_muscle_weight1.06421443
34MP0005083_abnormal_biliary_tract1.05564898
35MP0002249_abnormal_larynx_morphology1.03016411
36MP0002229_neurodegeneration0.98682771
37MP0003693_abnormal_embryo_hatching0.98550252
38MP0004742_abnormal_vestibular_system0.96710328
39MP0002735_abnormal_chemical_nociception0.96534107
40MP0002127_abnormal_cardiovascular_syste0.94872548
41MP0005551_abnormal_eye_electrophysiolog0.91904385
42MP0005636_abnormal_mineral_homeostasis0.91477456
43MP0005408_hypopigmentation0.87823844
44MP0008961_abnormal_basal_metabolism0.87608982
45MP0001963_abnormal_hearing_physiology0.85986370
46MP0009053_abnormal_anal_canal0.84400729
47MP0009115_abnormal_fat_cell0.83228553
48MP0000026_abnormal_inner_ear0.79289686
49MP0008995_early_reproductive_senescence0.77243073
50MP0001666_abnormal_nutrient_absorption0.74981094
51MP0005084_abnormal_gallbladder_morpholo0.74202511
52MP0003879_abnormal_hair_cell0.73968160
53MP0000534_abnormal_ureter_morphology0.73539929
54MP0004510_myositis0.73109234
55MP0003699_abnormal_female_reproductive0.73008853
56MP0005375_adipose_tissue_phenotype0.68539073
57MP0002822_catalepsy0.68393845
58MP0004085_abnormal_heartbeat0.64506482
59MP0005647_abnormal_sex_gland0.62744684
60MP0009697_abnormal_copulation0.62293023
61MP0000955_abnormal_spinal_cord0.61635869
62MP0003936_abnormal_reproductive_system0.60943613
63MP0005253_abnormal_eye_physiology0.60527737
64MP0000015_abnormal_ear_pigmentation0.58672489
65MP0004782_abnormal_surfactant_physiolog0.56471921
66MP0006292_abnormal_olfactory_placode0.56045197
67MP0003119_abnormal_digestive_system0.54709819
68MP0002067_abnormal_sensory_capabilities0.54438075
69MP0006035_abnormal_mitochondrial_morpho0.53754534
70MP0002733_abnormal_thermal_nociception0.51775610
71MP0002557_abnormal_social/conspecific_i0.51381848
72MP0001764_abnormal_homeostasis0.50543985
73MP0005248_abnormal_Harderian_gland0.50411932
74MP0000467_abnormal_esophagus_morphology0.49481161
75MP0005332_abnormal_amino_acid0.49343014
76MP0000470_abnormal_stomach_morphology0.49298274
77MP0001440_abnormal_grooming_behavior0.47133652
78MP0004019_abnormal_vitamin_homeostasis0.47127572
79MP0003787_abnormal_imprinting0.46888636
80MP0002272_abnormal_nervous_system0.45866427
81MP0004859_abnormal_synaptic_plasticity0.45036207
82MP0000516_abnormal_urinary_system0.44682511
83MP0005367_renal/urinary_system_phenotyp0.44682511
84MP0006036_abnormal_mitochondrial_physio0.44098305
85MP0008058_abnormal_DNA_repair0.43373067
86MP0001905_abnormal_dopamine_level0.43243488
87MP0005365_abnormal_bile_salt0.42827149
88MP0000681_abnormal_thyroid_gland0.42541713
89MP0004484_altered_response_of0.40828026
90MP0000049_abnormal_middle_ear0.40693755
91MP0002085_abnormal_embryonic_tissue0.40222252
92MP0001119_abnormal_female_reproductive0.39684265
93MP0010386_abnormal_urinary_bladder0.38798701
94MP0002254_reproductive_system_inflammat0.38606064
95MP0001879_abnormal_lymphatic_vessel0.38399761
96MP0001501_abnormal_sleep_pattern0.37021357
97MP0008770_decreased_survivor_rate0.36443962
98MP0002734_abnormal_mechanical_nocicepti0.36244948
99MP0003136_yellow_coat_color0.35315054
100MP0005167_abnormal_blood-brain_barrier0.34588297

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.96075236
2Absent/shortened dynein arms (HP:0200106)5.61920066
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.61920066
4Attenuation of retinal blood vessels (HP:0007843)5.12060910
5Azoospermia (HP:0000027)5.04883397
6Tubulointerstitial nephritis (HP:0001970)4.94977002
7Bony spicule pigmentary retinopathy (HP:0007737)4.94630448
8Chronic hepatic failure (HP:0100626)4.67879063
9Abnormal spermatogenesis (HP:0008669)4.62723282
10Abnormal ciliary motility (HP:0012262)4.41714813
11Infertility (HP:0000789)4.38588886
12Abnormal respiratory motile cilium physiology (HP:0012261)4.37909468
13Asymmetric septal hypertrophy (HP:0001670)4.23306607
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.23081671
15Abnormal respiratory motile cilium morphology (HP:0005938)4.20685364
16Abnormal respiratory epithelium morphology (HP:0012253)4.20685364
17Hyperkalemia (HP:0002153)4.18742888
18Resting tremor (HP:0002322)4.18028930
19Male infertility (HP:0003251)4.13762556
20Bell-shaped thorax (HP:0001591)3.93968213
21Abnormal rod and cone electroretinograms (HP:0008323)3.92698504
22Abnormality of macular pigmentation (HP:0008002)3.90822779
23Cone-rod dystrophy (HP:0000548)3.88442395
24Impulsivity (HP:0100710)3.84763254
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.76647514
26Facial shape deformation (HP:0011334)3.61693421
27Potter facies (HP:0002009)3.61693421
28Nasal polyposis (HP:0100582)3.46028335
29Insulin-resistant diabetes mellitus (HP:0000831)3.45513422
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.29039646
31Amelogenesis imperfecta (HP:0000705)3.12649579
32Abnormality of the aortic arch (HP:0012303)3.08625825
33Generalized aminoaciduria (HP:0002909)2.99687216
34Enlarged epiphyses (HP:0010580)2.99498786
35Tetany (HP:0001281)2.97496628
36Unilateral renal agenesis (HP:0000122)2.95966564
37Congenital malformation of the right heart (HP:0011723)2.95273265
38Double outlet right ventricle (HP:0001719)2.95273265
39Progressive sensorineural hearing impairment (HP:0000408)2.93745016
40Abnormal urine output (HP:0012590)2.88159600
41Postural instability (HP:0002172)2.86195515
42Abnormality of the parathyroid morphology (HP:0011766)2.86111319
43Hypoplastic ischia (HP:0003175)2.81769579
44Hypoalphalipoproteinemia (HP:0003233)2.75504681
45Hypoplasia of the thymus (HP:0000778)2.73197787
46Abnormal drinking behavior (HP:0030082)2.68430406
47Polydipsia (HP:0001959)2.68430406
48Abnormality of the nasal mucosa (HP:0000433)2.66928246
49Rhinitis (HP:0012384)2.65695749
50Abnormality of potassium homeostasis (HP:0011042)2.60285423
51Abnormality of dental color (HP:0011073)2.46411851
52Abnormality of renal excretion (HP:0011036)2.45232282
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.44729285
54Osteomalacia (HP:0002749)2.42509632
55Abnormality of the ischium (HP:0003174)2.39867518
56Stage 5 chronic kidney disease (HP:0003774)2.39704307
57Polyuria (HP:0000103)2.34799080
58Abnormality of urine glucose concentration (HP:0011016)2.31298441
59Glycosuria (HP:0003076)2.31298441
60Renal dysplasia (HP:0000110)2.28182791
61Nephronophthisis (HP:0000090)2.21482164
62Truncal obesity (HP:0001956)2.20935052
63Tubulointerstitial abnormality (HP:0001969)2.20339946
64Abnormal ventriculo-arterial connection (HP:0011563)2.19376788
65Transposition of the great arteries (HP:0001669)2.19376788
66Abnormal connection of the cardiac segments (HP:0011545)2.19376788
67Pendular nystagmus (HP:0012043)2.17082154
68Chronic bronchitis (HP:0004469)2.15138431
69Renovascular hypertension (HP:0100817)2.14962605
70Widely patent fontanelles and sutures (HP:0004492)2.10450587
71Spastic paraparesis (HP:0002313)2.09814062
72Progressive hearing impairment (HP:0001730)2.09659879
73Renal Fanconi syndrome (HP:0001994)2.08805645
74Subcapsular cataract (HP:0000523)2.01865521
75Portal hypertension (HP:0001409)2.01245790
76Hypophosphatemic rickets (HP:0004912)2.01208242
77Flattened epiphyses (HP:0003071)1.96814765
78Increased purine levels (HP:0004368)1.95897908
79Hyperuricemia (HP:0002149)1.95897908
80Upper limb muscle weakness (HP:0003484)1.95683286
81Abnormality of the costochondral junction (HP:0000919)1.94399697
82Horizontal nystagmus (HP:0000666)1.93287793
83Seborrheic dermatitis (HP:0001051)1.90946539
84Sensory axonal neuropathy (HP:0003390)1.90068056
85Insulin resistance (HP:0000855)1.88982842
86Hyponatremia (HP:0002902)1.88975152
87Decreased central vision (HP:0007663)1.88792753
88Progressive cerebellar ataxia (HP:0002073)1.88714870
89Hypoparathyroidism (HP:0000829)1.86580300
90Hypoplasia of the fovea (HP:0007750)1.86423737
91Aplasia/Hypoplasia of the fovea (HP:0008060)1.86423737
92Abnormality of the renal medulla (HP:0100957)1.85272191
93Abnormality of the hepatic vasculature (HP:0006707)1.83917669
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76492507
95Amblyopia (HP:0000646)1.76473417
96Photophobia (HP:0000613)1.75677011
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73006367
98Bronchiectasis (HP:0002110)1.72727515
99Hypokalemia (HP:0002900)1.71578594
100Bilateral microphthalmos (HP:0007633)1.69472330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.05528727
2TESK15.20432957
3DDR23.66063319
4INSRR3.45906933
5PRKD33.41515204
6MAP4K23.08334428
7PLK23.05541557
8PNCK2.73784685
9STK382.69997164
10BRD42.59597092
11PBK2.53100526
12CAMK1G2.40053539
13STK38L2.30236118
14WNK42.05299031
15AKT31.87931420
16STK391.80707832
17MAPK151.79119160
18CDK71.52885221
19NEK61.51868432
20WNK11.43415341
21PDPK11.31930287
22CAMK1D1.26938295
23PDK11.23912612
24CDK121.20466637
25EIF2AK11.20074736
26MAP3K91.18489638
27MAP3K81.15018008
28EIF2AK31.14949157
29ZAK1.12807327
30KSR21.07785553
31MST1R1.07651039
32PIK3CG1.05724408
33DYRK1B0.97607892
34PINK10.95235964
35OXSR10.92844013
36TESK20.91262820
37SRPK10.82146281
38PDK20.81576214
39PTK2B0.80159463
40MAP3K20.75631132
41VRK20.73513607
42TYRO30.70761018
43BRAF0.64291704
44MAP2K20.63875921
45LMTK20.63872134
46LATS20.60067332
47RPS6KA10.58073929
48CAMK10.57261971
49PRKG10.52270872
50PRKAA20.52049944
51PRKG20.51968931
52STK160.50482345
53FER0.50421993
54CHEK10.49983081
55MUSK0.49047425
56CDK20.48917691
57CDK10.47603240
58TAF10.43835871
59GSK3B0.43712823
60MTOR0.43416206
61MAPK10.43061001
62PKN10.41761358
63RPS6KA20.38724508
64NEK20.37700217
65AURKA0.36689552
66ICK0.36444162
67ACVR1B0.36131065
68PRKCZ0.36034322
69PRKCG0.34957342
70TNK20.34942285
71UHMK10.34540091
72DYRK20.33647256
73PAK20.33212702
74CDK40.30651697
75CAMK40.30208944
76ROCK10.30040715
77MAPK140.25620929
78MAPK80.25605601
79RPS6KL10.24806727
80RPS6KC10.24806727
81KDR0.24677049
82MAP3K10.24542044
83RPS6KA60.24018258
84BRSK10.23962177
85CDK30.23061578
86BMPR1B0.22921560
87VRK10.22405829
88MKNK20.20810433
89MAPK100.19553299
90DYRK30.19538012
91GRK10.19395128
92BRSK20.19212212
93CDK190.18587334
94AKT10.17745412
95ARAF0.17505571
96LATS10.16808645
97ABL20.16765991
98NTRK30.16556817
99PLK10.15926238
100PASK0.15755989

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.08363639
2Fatty acid biosynthesis_Homo sapiens_hsa000616.23921933
3Olfactory transduction_Homo sapiens_hsa047402.92695573
4RNA transport_Homo sapiens_hsa030132.81471396
5Basal transcription factors_Homo sapiens_hsa030222.36706785
6Butanoate metabolism_Homo sapiens_hsa006502.30649905
7Phenylalanine metabolism_Homo sapiens_hsa003602.12792069
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06974012
9Fatty acid degradation_Homo sapiens_hsa000711.92421474
10Fatty acid metabolism_Homo sapiens_hsa012121.76729354
11Glycerophospholipid metabolism_Homo sapiens_hsa005641.75346300
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68453990
13Arginine and proline metabolism_Homo sapiens_hsa003301.64562057
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48594121
15Phototransduction_Homo sapiens_hsa047441.42630670
16Dorso-ventral axis formation_Homo sapiens_hsa043201.42223256
17Cardiac muscle contraction_Homo sapiens_hsa042601.35053460
18Huntingtons disease_Homo sapiens_hsa050161.34972782
19Synaptic vesicle cycle_Homo sapiens_hsa047211.34784437
20Selenocompound metabolism_Homo sapiens_hsa004501.32841087
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32745771
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31930262
23mRNA surveillance pathway_Homo sapiens_hsa030151.29037284
24Collecting duct acid secretion_Homo sapiens_hsa049661.24670551
25Taste transduction_Homo sapiens_hsa047421.23913147
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12496919
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06560267
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03776374
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.03211141
30Type II diabetes mellitus_Homo sapiens_hsa049300.98805517
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98673723
32Mineral absorption_Homo sapiens_hsa049780.96742626
33PPAR signaling pathway_Homo sapiens_hsa033200.96531284
34Arginine biosynthesis_Homo sapiens_hsa002200.94320800
35Endocytosis_Homo sapiens_hsa041440.94224981
36Purine metabolism_Homo sapiens_hsa002300.92906992
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87742517
38Renin-angiotensin system_Homo sapiens_hsa046140.85928260
39Oocyte meiosis_Homo sapiens_hsa041140.84952148
40RNA polymerase_Homo sapiens_hsa030200.84412410
41Biosynthesis of amino acids_Homo sapiens_hsa012300.84155327
42Retinol metabolism_Homo sapiens_hsa008300.83996161
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83413343
44Oxidative phosphorylation_Homo sapiens_hsa001900.82821938
45Linoleic acid metabolism_Homo sapiens_hsa005910.82622586
46Antigen processing and presentation_Homo sapiens_hsa046120.80555744
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80337573
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78232820
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77777305
50Propanoate metabolism_Homo sapiens_hsa006400.76708710
51Tyrosine metabolism_Homo sapiens_hsa003500.76461383
52Fat digestion and absorption_Homo sapiens_hsa049750.74565529
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71092681
54beta-Alanine metabolism_Homo sapiens_hsa004100.69661684
55Peroxisome_Homo sapiens_hsa041460.66084330
56Carbon metabolism_Homo sapiens_hsa012000.65975118
57Protein digestion and absorption_Homo sapiens_hsa049740.63054435
58Inositol phosphate metabolism_Homo sapiens_hsa005620.62386569
59RNA degradation_Homo sapiens_hsa030180.62158729
60Type I diabetes mellitus_Homo sapiens_hsa049400.61750300
61Fanconi anemia pathway_Homo sapiens_hsa034600.61607072
62Hedgehog signaling pathway_Homo sapiens_hsa043400.60743360
63Histidine metabolism_Homo sapiens_hsa003400.60457985
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59613481
65Spliceosome_Homo sapiens_hsa030400.59498339
66Autoimmune thyroid disease_Homo sapiens_hsa053200.59474777
67Pyruvate metabolism_Homo sapiens_hsa006200.59254544
68Metabolic pathways_Homo sapiens_hsa011000.56436958
69Allograft rejection_Homo sapiens_hsa053300.55716258
70Proteasome_Homo sapiens_hsa030500.55187626
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.54883420
72Ribosome_Homo sapiens_hsa030100.54468074
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54350784
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51331983
75Tight junction_Homo sapiens_hsa045300.50809410
76Bile secretion_Homo sapiens_hsa049760.50656515
77Vitamin B6 metabolism_Homo sapiens_hsa007500.48932482
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48146488
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.47592217
80Graft-versus-host disease_Homo sapiens_hsa053320.47288597
81Parkinsons disease_Homo sapiens_hsa050120.46413434
82Pyrimidine metabolism_Homo sapiens_hsa002400.45720248
83Calcium signaling pathway_Homo sapiens_hsa040200.43480317
84Base excision repair_Homo sapiens_hsa034100.42056956
85Nucleotide excision repair_Homo sapiens_hsa034200.41002390
86Viral myocarditis_Homo sapiens_hsa054160.40703707
87Homologous recombination_Homo sapiens_hsa034400.40629622
88ABC transporters_Homo sapiens_hsa020100.40052716
89One carbon pool by folate_Homo sapiens_hsa006700.39497639
90Morphine addiction_Homo sapiens_hsa050320.36512638
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.35869589
92Salivary secretion_Homo sapiens_hsa049700.34185871
93Tryptophan metabolism_Homo sapiens_hsa003800.33256063
94Influenza A_Homo sapiens_hsa051640.30159139
95cAMP signaling pathway_Homo sapiens_hsa040240.29988865
96Vitamin digestion and absorption_Homo sapiens_hsa049770.27759987
97Viral carcinogenesis_Homo sapiens_hsa052030.27279416
98Chemical carcinogenesis_Homo sapiens_hsa052040.26517175
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.24575397
100Serotonergic synapse_Homo sapiens_hsa047260.23190383

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