VBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.31261557
2central nervous system myelination (GO:0022010)8.31261557
3fatty acid elongation (GO:0030497)5.39149734
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.21681525
5protein neddylation (GO:0045116)5.18074937
6long-chain fatty acid biosynthetic process (GO:0042759)5.11219982
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.93756195
8ATP synthesis coupled proton transport (GO:0015986)4.93756195
9DNA double-strand break processing (GO:0000729)4.80846213
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.76284798
11chaperone-mediated protein transport (GO:0072321)4.28660401
12myelination (GO:0042552)4.25446647
13ensheathment of neurons (GO:0007272)4.23802830
14axon ensheathment (GO:0008366)4.23802830
15CENP-A containing nucleosome assembly (GO:0034080)4.16342174
16chromatin remodeling at centromere (GO:0031055)4.11491038
17negative regulation of neurotransmitter transport (GO:0051589)4.09539695
18establishment of mitochondrion localization (GO:0051654)4.01685932
19neuron cell-cell adhesion (GO:0007158)3.95670052
20presynaptic membrane organization (GO:0097090)3.86569796
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.85138330
22respiratory electron transport chain (GO:0022904)3.84789677
23cholesterol biosynthetic process (GO:0006695)3.80699532
24substantia nigra development (GO:0021762)3.80010273
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.79827320
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.79827320
27NADH dehydrogenase complex assembly (GO:0010257)3.79827320
28electron transport chain (GO:0022900)3.77004811
29presynaptic membrane assembly (GO:0097105)3.74125071
30protein localization to kinetochore (GO:0034501)3.73842868
31dopamine biosynthetic process (GO:0042416)3.50935647
32protein complex biogenesis (GO:0070271)3.50536793
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48442417
34microtubule depolymerization (GO:0007019)3.42189827
35histone exchange (GO:0043486)3.41934381
36DNA replication checkpoint (GO:0000076)3.39846377
37DNA replication-independent nucleosome assembly (GO:0006336)3.39679774
38DNA replication-independent nucleosome organization (GO:0034724)3.39679774
39sterol biosynthetic process (GO:0016126)3.38781257
40mannosylation (GO:0097502)3.38423774
41GPI anchor biosynthetic process (GO:0006506)3.33956739
42regulation of collateral sprouting (GO:0048670)3.33492970
43isoprenoid biosynthetic process (GO:0008299)3.29487497
44microtubule polymerization or depolymerization (GO:0031109)3.29241500
45negative regulation of neurotransmitter secretion (GO:0046929)3.29233240
46DNA ligation (GO:0006266)3.27543477
47replication fork processing (GO:0031297)3.23922556
48glycerophospholipid catabolic process (GO:0046475)3.22446465
49negative regulation of DNA recombination (GO:0045910)3.22056846
50organelle disassembly (GO:1903008)3.17440633
51mitochondrial respiratory chain complex assembly (GO:0033108)3.17211258
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17017568
53neurotransmitter uptake (GO:0001504)3.16041651
54GPI anchor metabolic process (GO:0006505)3.15950126
55mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.10896315
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10816939
57kinetochore organization (GO:0051383)3.10347017
58protein localization to chromosome, centromeric region (GO:0071459)3.09142736
59DNA damage response, detection of DNA damage (GO:0042769)3.08544937
60ribonucleoprotein complex disassembly (GO:0032988)3.08389340
61histone H2B ubiquitination (GO:0033523)3.07959736
62positive regulation of oligodendrocyte differentiation (GO:0048714)3.07444810
63mitotic metaphase plate congression (GO:0007080)3.05905822
64regulation of catecholamine metabolic process (GO:0042069)3.05683573
65regulation of dopamine metabolic process (GO:0042053)3.05683573
66spindle checkpoint (GO:0031577)3.05469323
67DNA replication-dependent nucleosome assembly (GO:0006335)3.03280575
68DNA replication-dependent nucleosome organization (GO:0034723)3.03280575
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03274853
70proteasome assembly (GO:0043248)3.02296314
71DNA catabolic process, exonucleolytic (GO:0000738)3.01693380
72oligodendrocyte differentiation (GO:0048709)3.01167138
73metaphase plate congression (GO:0051310)2.98289101
74response to redox state (GO:0051775)2.97037200
75histone H2A acetylation (GO:0043968)2.95374177
76preassembly of GPI anchor in ER membrane (GO:0016254)2.94671695
77negative regulation of protein localization to cell surface (GO:2000009)2.94365296
78histone mRNA metabolic process (GO:0008334)2.94281372
79mitotic spindle checkpoint (GO:0071174)2.92488582
80myelin maintenance (GO:0043217)2.91998200
81sister chromatid segregation (GO:0000819)2.91623945
82telomere maintenance via semi-conservative replication (GO:0032201)2.91244671
83transmission of nerve impulse (GO:0019226)2.91231955
84mitotic sister chromatid segregation (GO:0000070)2.90916456
85regulation of feeding behavior (GO:0060259)2.89536348
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88086892
87regulation of mitotic spindle checkpoint (GO:1903504)2.88086892
88cullin deneddylation (GO:0010388)2.86731075
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.86580484
90resolution of meiotic recombination intermediates (GO:0000712)2.86206480
91DNA strand elongation involved in DNA replication (GO:0006271)2.85621890
92kinetochore assembly (GO:0051382)2.85621136
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84588632
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83310145
95purine nucleobase biosynthetic process (GO:0009113)2.82756316
96establishment of integrated proviral latency (GO:0075713)2.82299935
97IMP biosynthetic process (GO:0006188)2.81305870
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80917708
99photoreceptor cell differentiation (GO:0046530)2.80832551
100eye photoreceptor cell differentiation (GO:0001754)2.80832551
101attachment of spindle microtubules to kinetochore (GO:0008608)2.80121981
102negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79971137
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.79971137
104negative regulation of sister chromatid segregation (GO:0033046)2.79971137
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79971137
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79971137
107apical protein localization (GO:0045176)2.79828952
108magnesium ion transport (GO:0015693)2.79436702
109maturation of 5.8S rRNA (GO:0000460)2.79417690
110pyrimidine nucleobase catabolic process (GO:0006208)2.78645649
111spindle assembly checkpoint (GO:0071173)2.78214478
112sequestering of actin monomers (GO:0042989)2.78196737
113establishment of viral latency (GO:0019043)2.75480134
114protein K11-linked ubiquitination (GO:0070979)2.75152616
115RNA capping (GO:0036260)2.74911005
1167-methylguanosine RNA capping (GO:0009452)2.74911005
117negative regulation of chromosome segregation (GO:0051985)2.74395007
118protein-cofactor linkage (GO:0018065)2.74285494
119mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.74037630
120positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.74037630
121positive regulation of mitochondrial fission (GO:0090141)2.73855926
122non-recombinational repair (GO:0000726)2.73685779
123double-strand break repair via nonhomologous end joining (GO:0006303)2.73685779
124neural nucleus development (GO:0048857)2.73489728
125dopamine transport (GO:0015872)2.73445507
126mitotic spindle assembly checkpoint (GO:0007094)2.73358149
127protein targeting to mitochondrion (GO:0006626)2.73096641
128protein K6-linked ubiquitination (GO:0085020)2.72801259
129DNA strand elongation (GO:0022616)2.72550768
130spliceosomal snRNP assembly (GO:0000387)2.72362205
131postreplication repair (GO:0006301)2.71879268
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.71814178
1337-methylguanosine mRNA capping (GO:0006370)2.71813219
134establishment of protein localization to mitochondrion (GO:0072655)2.71219565
135mitotic spindle organization (GO:0007052)2.70897627
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70800942
137regulation of centriole replication (GO:0046599)2.70467886
138regulation of helicase activity (GO:0051095)2.66734772
139gamma-aminobutyric acid signaling pathway (GO:0007214)2.61141017
140L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59948870
141neuron recognition (GO:0008038)2.58028974
142limb bud formation (GO:0060174)2.57899757
143positive regulation of ligase activity (GO:0051351)2.55593698
144neuron remodeling (GO:0016322)2.54797010
145transcription elongation from RNA polymerase III promoter (GO:0006385)2.54064233
146termination of RNA polymerase III transcription (GO:0006386)2.54064233
147mitotic recombination (GO:0006312)2.53939229
148astrocyte development (GO:0014002)2.53870037
149IMP metabolic process (GO:0046040)2.53543330
150regulation of ubiquitin-protein transferase activity (GO:0051438)2.52223644
151protein deneddylation (GO:0000338)2.51234257
152regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51180148
153regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.51180148
154regulation of chromosome segregation (GO:0051983)2.50440358
155positive regulation of action potential (GO:0045760)2.50137960
156termination of RNA polymerase II transcription (GO:0006369)2.50047895
157asymmetric protein localization (GO:0008105)2.49933045
158negative regulation of execution phase of apoptosis (GO:1900118)2.49516398
159telomere maintenance via recombination (GO:0000722)2.49281923
160negative regulation of JUN kinase activity (GO:0043508)2.48761241
161somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48674287
162somatic hypermutation of immunoglobulin genes (GO:0016446)2.48674287
163negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48192304
164regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47762000
165positive regulation of synapse assembly (GO:0051965)2.47338699
166GTP biosynthetic process (GO:0006183)2.47146177
167protein localization to mitochondrion (GO:0070585)2.46908084
168regulation of mitotic sister chromatid segregation (GO:0033047)2.46871775
169regulation of sister chromatid segregation (GO:0033045)2.46871775
170negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.45916251
171negative regulation of ligase activity (GO:0051352)2.45916251
172hydrogen ion transmembrane transport (GO:1902600)2.44656190
173negative regulation of microtubule polymerization (GO:0031115)2.43607650
174adult walking behavior (GO:0007628)2.43033146
175neuronal action potential propagation (GO:0019227)2.42628513
176C-terminal protein lipidation (GO:0006501)2.38909071
177peptidyl-cysteine modification (GO:0018198)2.35930472
178dendrite development (GO:0016358)2.35154701
179catecholamine biosynthetic process (GO:0042423)2.33239086
180catechol-containing compound biosynthetic process (GO:0009713)2.33239086
181positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.32152317
182regulation of glutamate secretion (GO:0014048)2.30828101
183regulation of cellular amino acid metabolic process (GO:0006521)2.30773866
184cranial nerve development (GO:0021545)2.29757358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.24526482
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.97418616
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.91706374
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38231582
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02385791
6GBX2_23144817_ChIP-Seq_PC3_Human2.94033612
7TAF15_26573619_Chip-Seq_HEK293_Human2.91124181
8EZH2_22144423_ChIP-Seq_EOC_Human2.73686207
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.69638641
10VDR_22108803_ChIP-Seq_LS180_Human2.64050204
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55868545
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55179549
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55105143
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42282260
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.40564262
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.36588106
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33198647
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32681099
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.28000656
20FUS_26573619_Chip-Seq_HEK293_Human2.26422826
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26410529
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.25545857
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21381823
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16023761
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.10622039
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09457332
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05529888
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03653235
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90555604
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89894798
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89697620
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87591589
33DCP1A_22483619_ChIP-Seq_HELA_Human1.87321256
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85013336
35IGF1R_20145208_ChIP-Seq_DFB_Human1.83402299
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82202865
37ER_23166858_ChIP-Seq_MCF-7_Human1.79920582
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79509921
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78822019
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77849427
41FOXP3_21729870_ChIP-Seq_TREG_Human1.75720474
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75604683
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73496095
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68964650
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.68499686
46EWS_26573619_Chip-Seq_HEK293_Human1.68097235
47MYC_18940864_ChIP-ChIP_HL60_Human1.67339166
48AR_21909140_ChIP-Seq_LNCAP_Human1.67054189
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62889712
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61647677
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.61466674
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60488623
53IRF1_19129219_ChIP-ChIP_H3396_Human1.60291746
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.59590045
55RNF2_27304074_Chip-Seq_NSC_Mouse1.58422942
56P300_19829295_ChIP-Seq_ESCs_Human1.58299880
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56826050
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55709503
59GABP_19822575_ChIP-Seq_HepG2_Human1.47480041
60TTF2_22483619_ChIP-Seq_HELA_Human1.45680006
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.44162704
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44081182
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41765491
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40182908
65ELK1_19687146_ChIP-ChIP_HELA_Human1.39334301
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39324201
67* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37244316
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36901646
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34966073
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33300237
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31953487
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31067815
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31045918
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26560578
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.24605496
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23680156
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23397137
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.23244074
79XRN2_22483619_ChIP-Seq_HELA_Human1.22981128
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.20512460
81* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19980501
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19910180
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19893907
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19571213
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18594598
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18545583
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18181140
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18078213
89REST_21632747_ChIP-Seq_MESCs_Mouse1.17867210
90VDR_23849224_ChIP-Seq_CD4+_Human1.17080157
91* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16450541
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.16334279
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.15571332
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15210039
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14601422
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.14503510
97MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13986858
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13856395
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11769679
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10468334
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.09933154
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07033825
103REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07004554
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06872101
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06406943
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04019495
107NANOG_16153702_ChIP-ChIP_HESCs_Human1.03802006
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.03681475
109JUN_21703547_ChIP-Seq_K562_Human1.03206375
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01891921
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01655568
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01258837
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01087271
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00219962
115AR_21572438_ChIP-Seq_LNCaP_Human0.99026785
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98658932
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98250361
118TP53_22573176_ChIP-Seq_HFKS_Human0.98125993
119P300_18555785_Chip-Seq_ESCs_Mouse0.97834134
120SOX9_26525672_Chip-Seq_HEART_Mouse0.97120706
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.96611090
122* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96221305
123REST_18959480_ChIP-ChIP_MESCs_Mouse0.94727634
124RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94723067
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94723067
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94665074
127MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93880766
128SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93662983
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93560646
130* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93498532
131EZH2_27294783_Chip-Seq_ESCs_Mouse0.93373773
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.92620026
133HTT_18923047_ChIP-ChIP_STHdh_Human0.91969880
134ZNF274_21170338_ChIP-Seq_K562_Hela0.91788287
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91781053
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.91172815
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91007930
138SOX2_19829295_ChIP-Seq_ESCs_Human0.89623069
139NANOG_19829295_ChIP-Seq_ESCs_Human0.89623069
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87554890
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87196729
142CBP_20019798_ChIP-Seq_JUKART_Human0.87196729
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85726026
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.85724503
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85005455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.56623697
2MP0001529_abnormal_vocalization4.19689115
3MP0001905_abnormal_dopamine_level3.26941784
4MP0000920_abnormal_myelination3.22280776
5MP0010094_abnormal_chromosome_stability3.21612610
6MP0008058_abnormal_DNA_repair3.13877823
7MP0005423_abnormal_somatic_nervous2.94270590
8MP0004270_analgesia2.87353073
9MP0003693_abnormal_embryo_hatching2.56434313
10MP0002272_abnormal_nervous_system2.53761865
11MP0004142_abnormal_muscle_tone2.42489320
12MP0004957_abnormal_blastocyst_morpholog2.41901607
13MP0006276_abnormal_autonomic_nervous2.39727424
14MP0002734_abnormal_mechanical_nocicepti2.30947239
15MP0003136_yellow_coat_color2.21274482
16MP0003111_abnormal_nucleus_morphology2.19852536
17MP0009697_abnormal_copulation2.15178989
18MP0002064_seizures2.15172179
19MP0000778_abnormal_nervous_system2.14159763
20MP0004742_abnormal_vestibular_system2.10166432
21MP0001486_abnormal_startle_reflex2.07021730
22MP0003077_abnormal_cell_cycle1.99729080
23MP0005171_absent_coat_pigmentation1.97758164
24MP0009745_abnormal_behavioral_response1.96752387
25MP0009046_muscle_twitch1.96133748
26MP0003950_abnormal_plasma_membrane1.95268936
27MP0003635_abnormal_synaptic_transmissio1.91086326
28MP0005645_abnormal_hypothalamus_physiol1.80827678
29MP0001968_abnormal_touch/_nociception1.80147501
30MP0005409_darkened_coat_color1.79714239
31MP0002735_abnormal_chemical_nociception1.77589829
32MP0002572_abnormal_emotion/affect_behav1.75976155
33MP0001440_abnormal_grooming_behavior1.72927819
34MP0006072_abnormal_retinal_apoptosis1.72122884
35MP0005551_abnormal_eye_electrophysiolog1.72023472
36MP0005187_abnormal_penis_morphology1.71765580
37MP0001188_hyperpigmentation1.71636310
38MP0003890_abnormal_embryonic-extraembry1.70423458
39MP0001986_abnormal_taste_sensitivity1.69810020
40MP0001970_abnormal_pain_threshold1.66504679
41MP0003787_abnormal_imprinting1.65512049
42MP0001485_abnormal_pinna_reflex1.64405586
43MP0002234_abnormal_pharynx_morphology1.64285142
44MP0003221_abnormal_cardiomyocyte_apopto1.61365727
45MP0002736_abnormal_nociception_after1.60792319
46MP0004924_abnormal_behavior1.57538154
47MP0005386_behavior/neurological_phenoty1.57538154
48MP0003634_abnormal_glial_cell1.57496148
49MP0009379_abnormal_foot_pigmentation1.57293316
50MP0002063_abnormal_learning/memory/cond1.54245970
51MP0002067_abnormal_sensory_capabilities1.52770699
52MP0004885_abnormal_endolymph1.52541386
53MP0008007_abnormal_cellular_replicative1.50549921
54MP0002229_neurodegeneration1.49255904
55MP0002184_abnormal_innervation1.47712370
56MP0002733_abnormal_thermal_nociception1.45806346
57MP0001984_abnormal_olfaction1.42545370
58MP0000955_abnormal_spinal_cord1.38639141
59MP0002882_abnormal_neuron_morphology1.38570875
60MP0003786_premature_aging1.38261974
61MP0003329_amyloid_beta_deposits1.36624756
62MP0001293_anophthalmia1.35328433
63MP0008260_abnormal_autophagy1.32072042
64MP0003567_abnormal_fetal_cardiomyocyte1.31876841
65MP0008057_abnormal_DNA_replication1.31581228
66MP0002751_abnormal_autonomic_nervous1.31332886
67MP0002752_abnormal_somatic_nervous1.30672860
68MP0004859_abnormal_synaptic_plasticity1.28450696
69MP0002090_abnormal_vision1.27129123
70MP0004215_abnormal_myocardial_fiber1.25832280
71MP0001963_abnormal_hearing_physiology1.24776211
72MP0000647_abnormal_sebaceous_gland1.24026710
73MP0000631_abnormal_neuroendocrine_gland1.23175922
74MP0000049_abnormal_middle_ear1.20388386
75MP0006036_abnormal_mitochondrial_physio1.20132164
76MP0003632_abnormal_nervous_system1.19057153
77MP0002066_abnormal_motor_capabilities/c1.18802945
78MP0005410_abnormal_fertilization1.18379109
79MP0003315_abnormal_perineum_morphology1.17854825
80MP0000372_irregular_coat_pigmentation1.16028270
81MP0002638_abnormal_pupillary_reflex1.15587496
82MP0003122_maternal_imprinting1.15584139
83MP0005253_abnormal_eye_physiology1.15502939
84MP0008995_early_reproductive_senescence1.15493174
85MP0001501_abnormal_sleep_pattern1.14863458
86MP0003119_abnormal_digestive_system1.11190355
87MP0002210_abnormal_sex_determination1.10310874
88MP0002837_dystrophic_cardiac_calcinosis1.09867688
89MP0002163_abnormal_gland_morphology1.08804404
90MP0003690_abnormal_glial_cell1.08742806
91MP0005379_endocrine/exocrine_gland_phen1.07423388
92MP0004147_increased_porphyrin_level1.03666482
93MP0001502_abnormal_circadian_rhythm1.02935663
94MP0002233_abnormal_nose_morphology1.02217087
95MP0004134_abnormal_chest_morphology1.02067062
96MP0002557_abnormal_social/conspecific_i1.01684576
97MP0003186_abnormal_redox_activity0.99443338
98MP0006292_abnormal_olfactory_placode0.99442084
99MP0001929_abnormal_gametogenesis0.99363163
100MP0005195_abnormal_posterior_eye0.97804463
101MP0003806_abnormal_nucleotide_metabolis0.97634696
102MP0002938_white_spotting0.97294788
103MP0000026_abnormal_inner_ear0.97066064
104MP0002152_abnormal_brain_morphology0.94965778
105MP0003137_abnormal_impulse_conducting0.94714661
106MP0008789_abnormal_olfactory_epithelium0.94191441
107MP0002102_abnormal_ear_morphology0.93434235
108MP0008569_lethality_at_weaning0.92604323
109MP0003631_nervous_system_phenotype0.92525070
110MP0002084_abnormal_developmental_patter0.90455304
111MP0000358_abnormal_cell_content/0.90175615
112MP0000653_abnormal_sex_gland0.88732931
113MP0001286_abnormal_eye_development0.88529478
114MP0002822_catalepsy0.88484942
115MP0001145_abnormal_male_reproductive0.88009739
116MP0001730_embryonic_growth_arrest0.87680966
117MP0004145_abnormal_muscle_electrophysio0.86309708
118MP0003121_genomic_imprinting0.84942631
119MP0001348_abnormal_lacrimal_gland0.84177828
120MP0004133_heterotaxia0.84100600
121MP0001346_abnormal_lacrimal_gland0.83947501
122MP0002160_abnormal_reproductive_system0.83328076
123MP0003698_abnormal_male_reproductive0.82552551
124MP0001727_abnormal_embryo_implantation0.82290342
125MP0005391_vision/eye_phenotype0.82281224
126MP0001697_abnormal_embryo_size0.81553679
127MP0004043_abnormal_pH_regulation0.81406197
128MP0002085_abnormal_embryonic_tissue0.81291247
129MP0003938_abnormal_ear_development0.81046188
130MP0008877_abnormal_DNA_methylation0.80530192
131MP0008932_abnormal_embryonic_tissue0.80004338
132MP0005646_abnormal_pituitary_gland0.79882886
133MP0004811_abnormal_neuron_physiology0.79879760
134MP0006035_abnormal_mitochondrial_morpho0.78260135
135MP0005394_taste/olfaction_phenotype0.77900237
136MP0005499_abnormal_olfactory_system0.77900237
137MP0000566_synostosis0.75450862
138MP0003937_abnormal_limbs/digits/tail_de0.73050465
139MP0000462_abnormal_digestive_system0.72103153
140MP0003861_abnormal_nervous_system0.67586313
141MP0003718_maternal_effect0.67288631
142MP0010386_abnormal_urinary_bladder0.66368711

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.67311475
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.40148548
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.40148548
4Abnormality of glycolysis (HP:0004366)4.26589342
5Increased serum pyruvate (HP:0003542)4.26589342
6Abnormal mitochondria in muscle tissue (HP:0008316)4.06840753
7Mitochondrial inheritance (HP:0001427)3.93817403
8Progressive macrocephaly (HP:0004481)3.93589377
9Parakeratosis (HP:0001036)3.87204990
10Cerebral hypomyelination (HP:0006808)3.75903157
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.57193337
12Acute encephalopathy (HP:0006846)3.56170490
13Leukodystrophy (HP:0002415)3.46900770
14Increased hepatocellular lipid droplets (HP:0006565)3.36607693
15Renal Fanconi syndrome (HP:0001994)3.32933788
16Sensory axonal neuropathy (HP:0003390)3.25705550
17Hypothermia (HP:0002045)3.23783992
18Increased CSF lactate (HP:0002490)3.23472618
19Abnormality of the corticospinal tract (HP:0002492)3.21811565
20Hepatocellular necrosis (HP:0001404)3.21177308
21Neurofibrillary tangles (HP:0002185)3.17867072
223-Methylglutaconic aciduria (HP:0003535)3.07639986
23Limb dystonia (HP:0002451)3.06287484
24Neuroendocrine neoplasm (HP:0100634)3.05979766
25Volvulus (HP:0002580)3.02092456
26Pheochromocytoma (HP:0002666)3.01590188
27Retinal dysplasia (HP:0007973)2.95167117
28Cortical dysplasia (HP:0002539)2.88961373
29Peripheral hypomyelination (HP:0007182)2.83201976
30Myokymia (HP:0002411)2.74714587
31Lipid accumulation in hepatocytes (HP:0006561)2.73892603
32Degeneration of anterior horn cells (HP:0002398)2.73660301
33Abnormality of the anterior horn cell (HP:0006802)2.73660301
34CNS hypomyelination (HP:0003429)2.73489953
35Optic disc pallor (HP:0000543)2.68722797
36Medial flaring of the eyebrow (HP:0010747)2.61965710
37Methylmalonic acidemia (HP:0002912)2.60688798
38Gait imbalance (HP:0002141)2.60550126
39Autoamputation (HP:0001218)2.57416406
40Abnormal lung lobation (HP:0002101)2.51129471
41Colon cancer (HP:0003003)2.50255474
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48777704
43Meckel diverticulum (HP:0002245)2.45803679
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45241797
45Vaginal atresia (HP:0000148)2.42271550
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.41650359
47Genital tract atresia (HP:0001827)2.41057499
48Spastic gait (HP:0002064)2.38078367
49Abnormality of chromosome stability (HP:0003220)2.35629720
50Congenital primary aphakia (HP:0007707)2.34160177
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33651055
52Abnormality of the ileum (HP:0001549)2.33422092
53Congenital ichthyosiform erythroderma (HP:0007431)2.32758432
54True hermaphroditism (HP:0010459)2.31520655
55Renal cortical cysts (HP:0000803)2.29108134
56Medulloblastoma (HP:0002885)2.28747381
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.27102813
58Absent septum pellucidum (HP:0001331)2.24401032
59Atonic seizures (HP:0010819)2.23669584
60Hepatic necrosis (HP:0002605)2.23597589
61Cerebral inclusion bodies (HP:0100314)2.22559320
62Hyperglycinemia (HP:0002154)2.22499570
63Nephrogenic diabetes insipidus (HP:0009806)2.22417824
64Respiratory failure (HP:0002878)2.21176738
65Chromsome breakage (HP:0040012)2.21158663
66Abnormal hair whorl (HP:0010721)2.21051624
67Focal motor seizures (HP:0011153)2.14553896
68Abnormality of the septum pellucidum (HP:0007375)2.13544613
69Exercise intolerance (HP:0003546)2.10767780
70Abnormal auditory evoked potentials (HP:0006958)2.10650474
71Postnatal microcephaly (HP:0005484)2.07749319
72Shoulder girdle muscle weakness (HP:0003547)2.07689425
73Cerebral hemorrhage (HP:0001342)2.07335926
74Abnormality of renal resorption (HP:0011038)2.04712087
75Increased intramyocellular lipid droplets (HP:0012240)2.02997221
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02282991
77Abnormality of alanine metabolism (HP:0010916)2.02282991
78Hyperalaninemia (HP:0003348)2.02282991
79Exercise-induced muscle cramps (HP:0003710)2.00098147
80Morphological abnormality of the inner ear (HP:0011390)1.99815203
81X-linked dominant inheritance (HP:0001423)1.99680167
82Abnormality of the hip-girdle musculature (HP:0001445)1.99343443
83Abnormality of the musculature of the pelvis (HP:0001469)1.99343443
84Poor suck (HP:0002033)1.98936072
85Pancreatic fibrosis (HP:0100732)1.97678950
86Duodenal stenosis (HP:0100867)1.97372151
87Small intestinal stenosis (HP:0012848)1.97372151
88Akinesia (HP:0002304)1.97370133
89Increased serum lactate (HP:0002151)1.96091315
90Ankle clonus (HP:0011448)1.94277212
91Cerebral edema (HP:0002181)1.93954067
92Pancreatic cysts (HP:0001737)1.92818437
93Alacrima (HP:0000522)1.92611390
94Drooling (HP:0002307)1.92168369
95Abnormality of the preputium (HP:0100587)1.91637564
96Abnormal pupillary function (HP:0007686)1.90405093
97Birth length less than 3rd percentile (HP:0003561)1.89853287
98Septo-optic dysplasia (HP:0100842)1.87834906
99Methylmalonic aciduria (HP:0012120)1.87418939
100Patchy hypopigmentation of hair (HP:0011365)1.87266673
101Hypoplastic pelvis (HP:0008839)1.87223482
102Abnormality of serum amino acid levels (HP:0003112)1.85693745
103Abnormality of midbrain morphology (HP:0002418)1.85077245
104Molar tooth sign on MRI (HP:0002419)1.85077245
105Scanning speech (HP:0002168)1.84995812
106Delusions (HP:0000746)1.81004226
107Abnormality of the duodenum (HP:0002246)1.80710491
108Abnormality of methionine metabolism (HP:0010901)1.80377801
109Dysmetria (HP:0001310)1.79740581
110Intestinal atresia (HP:0011100)1.79286281
111Supranuclear gaze palsy (HP:0000605)1.78717071
112Exertional dyspnea (HP:0002875)1.78025619
113Stenosis of the external auditory canal (HP:0000402)1.77612036
114Lactic acidosis (HP:0003128)1.77562503
115Glioma (HP:0009733)1.77562156
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75588210
117Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75588210
118Nephroblastoma (Wilms tumor) (HP:0002667)1.75295943
119Sloping forehead (HP:0000340)1.74264672
120Hypomagnesemia (HP:0002917)1.73787017
121Embryonal renal neoplasm (HP:0011794)1.73501794
122Specific learning disability (HP:0001328)1.73157167
123Ependymoma (HP:0002888)1.71766366
124Decreased testicular size (HP:0008734)1.71675047
125Type I transferrin isoform profile (HP:0003642)1.71461392
126Anteriorly placed anus (HP:0001545)1.71263405
127Esotropia (HP:0000565)1.71186311
128White forelock (HP:0002211)1.70384736
129Amyotrophic lateral sclerosis (HP:0007354)1.69766768
130Broad-based gait (HP:0002136)1.69634067
131Nephronophthisis (HP:0000090)1.69009940
132Poor speech (HP:0002465)1.68349041
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.67713639
134Abnormality of the labia minora (HP:0012880)1.67337058
135Adrenal hypoplasia (HP:0000835)1.66926754
136Lissencephaly (HP:0001339)1.65886906
137Irregular epiphyses (HP:0010582)1.65583244
138Hypoglycemic coma (HP:0001325)1.65287214
139Excessive salivation (HP:0003781)1.64870487
140Epileptic encephalopathy (HP:0200134)1.64777690
141Aplasia/Hypoplasia of the lens (HP:0008063)1.64579070
142Short tibia (HP:0005736)1.63838947
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63400637
144Abnormality of the astrocytes (HP:0100707)1.63201239
145Astrocytoma (HP:0009592)1.63201239
146Abnormality of glycine metabolism (HP:0010895)1.63115086
147Abnormality of serine family amino acid metabolism (HP:0010894)1.63115086
148Broad foot (HP:0001769)1.62965039
149Progressive inability to walk (HP:0002505)1.62282472
150Triphalangeal thumb (HP:0001199)1.61999611
151Respiratory difficulties (HP:0002880)1.61966886
152Abnormal autonomic nervous system physiology (HP:0012332)1.61110327
153Onion bulb formation (HP:0003383)1.60547943
154Insidious onset (HP:0003587)1.60275184
155Termporal pattern (HP:0011008)1.60275184
156Pelvic girdle muscle weakness (HP:0003749)1.59968146
157Postaxial hand polydactyly (HP:0001162)1.58621753
158Decreased lacrimation (HP:0000633)1.55303294
159Poor coordination (HP:0002370)1.55263950
160Spastic paraparesis (HP:0002313)1.55074732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.08551028
2NEK13.62439462
3TRIM283.39074288
4OXSR13.10018334
5BCR2.88428809
6PNCK2.64779341
7PBK2.55149794
8LIMK12.36666077
9CASK2.35413996
10STK162.31051376
11TNIK2.26629593
12MAPKAPK52.25413763
13BUB12.24374289
14CSNK1G32.19530465
15MST42.18268426
16MARK12.01557446
17CDC72.00040939
18CDK191.92423469
19PKN11.86610101
20TTK1.84410403
21TESK21.79000052
22UHMK11.77878135
23BMPR1B1.73190432
24ZAK1.71971489
25DYRK21.68515906
26CSNK1A1L1.59709498
27CSNK1G21.55734509
28GRK71.53022516
29CSNK1G11.52011257
30WNK41.45308371
31ARAF1.44498196
32MAP4K21.43995617
33CAMK2B1.42208368
34VRK11.40698246
35CCNB11.40524429
36MAPK131.37243737
37NUAK11.36904454
38DYRK31.34050207
39PLK11.33348114
40ADRBK21.32073758
41MKNK11.30183275
42NME11.29686520
43RPS6KA41.26115713
44MAP3K121.25575420
45SRPK11.24923266
46EIF2AK31.24682781
47NEK61.12482382
48VRK21.11822037
49MAP2K71.11643033
50CAMK2D1.08651695
51FGR1.06152828
52ROCK21.05292955
53SIK31.04435216
54NTRK11.04078129
55PRPF4B1.02636264
56FGFR21.00759255
57BCKDK0.99598833
58TSSK60.99245449
59CDK140.99131700
60BRSK10.96114660
61GRK50.94210282
62ATR0.92642907
63PINK10.92456158
64MUSK0.92454357
65FRK0.92417881
66CDK180.87246301
67RPS6KA50.86865531
68CDK150.85974342
69EIF2AK20.85736492
70WNK10.83665411
71CAMK2A0.82531239
72NTRK20.82226084
73PLK20.80524139
74CDK11A0.79657760
75YES10.79628407
76CAMK2G0.79140509
77CHEK20.77685470
78CLK10.77411606
79MET0.75792012
80WEE10.74521299
81AURKB0.73059170
82INSRR0.72515287
83PLK30.72260832
84SGK4940.71797889
85SGK2230.71797889
86NEK20.71128819
87EIF2AK10.68757682
88CDK50.64107713
89EPHB10.63268136
90ATM0.61529058
91MINK10.61281401
92DYRK1A0.60583250
93MAP3K40.59983476
94NTRK30.59698889
95WNK30.59698224
96BRAF0.58979443
97MAP2K40.57802856
98TAF10.57507611
99PRKCE0.56585712
100PHKG20.55317832
101PHKG10.55317832
102STK38L0.53457526
103AURKA0.52972241
104ADRBK10.52232532
105PDK20.49309378
106PAK30.48129746
107CDK30.47955758
108BMPR20.46628068
109MKNK20.46253612
110OBSCN0.44889568
111ERBB40.43055739
112TLK10.42614530
113CHEK10.42596718
114KSR10.42336821
115MAPK150.41530101
116EPHA30.40179503
117CSNK1A10.39780751
118CSNK2A20.39065963
119SCYL20.38758431
120PRKACA0.38283085
121PRKG10.36916356
122ERBB30.36126867
123CDK10.35644694
124PRKCG0.34947125
125PLK40.34821317
126DAPK10.33074445
127PAK60.33040157
128PRKACB0.32684388
129BRSK20.32684382
130CAMKK20.32679096
131PAK10.32325073
132PRKCQ0.32301080
133PRKD30.31842751
134MAP3K50.31592883
135EPHA40.31514333
136CSNK1D0.31169474
137CSNK1E0.30349370
138CSNK2A10.30338059

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.33938192
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.18773660
3Parkinsons disease_Homo sapiens_hsa050123.70166374
4Protein export_Homo sapiens_hsa030603.25365967
5Proteasome_Homo sapiens_hsa030503.13102127
6Alzheimers disease_Homo sapiens_hsa050102.78434396
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72890919
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59444955
9Fatty acid elongation_Homo sapiens_hsa000622.50683686
10Huntingtons disease_Homo sapiens_hsa050162.49158399
11Steroid biosynthesis_Homo sapiens_hsa001002.47901760
12RNA polymerase_Homo sapiens_hsa030202.31157391
13Ribosome_Homo sapiens_hsa030102.14472043
14Ether lipid metabolism_Homo sapiens_hsa005652.03970147
15Propanoate metabolism_Homo sapiens_hsa006401.98969951
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87298551
17Collecting duct acid secretion_Homo sapiens_hsa049661.82328245
18Nicotine addiction_Homo sapiens_hsa050331.80522030
19Base excision repair_Homo sapiens_hsa034101.78395023
20Serotonergic synapse_Homo sapiens_hsa047261.56425456
21Cardiac muscle contraction_Homo sapiens_hsa042601.54006301
22Vibrio cholerae infection_Homo sapiens_hsa051101.50284827
23Phototransduction_Homo sapiens_hsa047441.48187497
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44658119
25Basal transcription factors_Homo sapiens_hsa030221.39467797
26GABAergic synapse_Homo sapiens_hsa047271.39259796
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37816484
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37469431
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32557297
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31543375
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31384415
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.30090572
33Pyruvate metabolism_Homo sapiens_hsa006201.28597641
34Synaptic vesicle cycle_Homo sapiens_hsa047211.21961529
35Spliceosome_Homo sapiens_hsa030401.18637130
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17150392
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16702670
38Sphingolipid metabolism_Homo sapiens_hsa006001.13930310
39Morphine addiction_Homo sapiens_hsa050321.12343631
40One carbon pool by folate_Homo sapiens_hsa006701.12263107
41Selenocompound metabolism_Homo sapiens_hsa004501.10529561
42Vitamin B6 metabolism_Homo sapiens_hsa007501.09468486
43Folate biosynthesis_Homo sapiens_hsa007901.07962043
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07021800
45Nucleotide excision repair_Homo sapiens_hsa034201.06815019
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01972462
47Linoleic acid metabolism_Homo sapiens_hsa005911.01377864
48Axon guidance_Homo sapiens_hsa043601.00740450
49Glutamatergic synapse_Homo sapiens_hsa047241.00494171
50Non-homologous end-joining_Homo sapiens_hsa034500.99417651
51Rheumatoid arthritis_Homo sapiens_hsa053230.98495952
52Autoimmune thyroid disease_Homo sapiens_hsa053200.97782953
53Carbon metabolism_Homo sapiens_hsa012000.96014038
54Cocaine addiction_Homo sapiens_hsa050300.95052107
55Biosynthesis of amino acids_Homo sapiens_hsa012300.94009810
56Alcoholism_Homo sapiens_hsa050340.92015300
57Dopaminergic synapse_Homo sapiens_hsa047280.90853500
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90033920
59Taste transduction_Homo sapiens_hsa047420.89646355
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89262963
61Long-term depression_Homo sapiens_hsa047300.88969802
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86387766
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83316491
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80310508
65Mismatch repair_Homo sapiens_hsa034300.78548962
66Purine metabolism_Homo sapiens_hsa002300.77112065
67Amphetamine addiction_Homo sapiens_hsa050310.76669534
68Pyrimidine metabolism_Homo sapiens_hsa002400.76016308
69Sulfur metabolism_Homo sapiens_hsa009200.75649796
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75317020
71Peroxisome_Homo sapiens_hsa041460.74671810
72RNA degradation_Homo sapiens_hsa030180.73290602
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72765831
74Homologous recombination_Homo sapiens_hsa034400.69899950
75Circadian entrainment_Homo sapiens_hsa047130.69568157
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68103499
77p53 signaling pathway_Homo sapiens_hsa041150.66580665
78Fatty acid metabolism_Homo sapiens_hsa012120.65600782
79Phagosome_Homo sapiens_hsa041450.64809133
80Arachidonic acid metabolism_Homo sapiens_hsa005900.64713097
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63092025
82Graft-versus-host disease_Homo sapiens_hsa053320.62342344
83Regulation of autophagy_Homo sapiens_hsa041400.60967509
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59509096
85Cholinergic synapse_Homo sapiens_hsa047250.58050890
86Allograft rejection_Homo sapiens_hsa053300.57802776
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55759047
88Metabolic pathways_Homo sapiens_hsa011000.53924112
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53065310
90Oocyte meiosis_Homo sapiens_hsa041140.50874705
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49433154
92RNA transport_Homo sapiens_hsa030130.49279015
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48666729
94Olfactory transduction_Homo sapiens_hsa047400.48662296
95Asthma_Homo sapiens_hsa053100.45802412
96DNA replication_Homo sapiens_hsa030300.45150850
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44430223
98Histidine metabolism_Homo sapiens_hsa003400.44026142
99Renal cell carcinoma_Homo sapiens_hsa052110.42682060
100beta-Alanine metabolism_Homo sapiens_hsa004100.41844919
101Glutathione metabolism_Homo sapiens_hsa004800.40816127
102Gap junction_Homo sapiens_hsa045400.38984418
103Circadian rhythm_Homo sapiens_hsa047100.38746047
104N-Glycan biosynthesis_Homo sapiens_hsa005100.38743712
105Type I diabetes mellitus_Homo sapiens_hsa049400.38375452
106Long-term potentiation_Homo sapiens_hsa047200.38286265
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37000586
108Nitrogen metabolism_Homo sapiens_hsa009100.36201682
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.35263521
110Renin secretion_Homo sapiens_hsa049240.34108957
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33314772
112Systemic lupus erythematosus_Homo sapiens_hsa053220.33295720
113Hippo signaling pathway_Homo sapiens_hsa043900.33189127
114Epstein-Barr virus infection_Homo sapiens_hsa051690.32122601
115Tight junction_Homo sapiens_hsa045300.30989627
116TGF-beta signaling pathway_Homo sapiens_hsa043500.30821376
117Arginine and proline metabolism_Homo sapiens_hsa003300.30471888
118Ras signaling pathway_Homo sapiens_hsa040140.30442801
119Tyrosine metabolism_Homo sapiens_hsa003500.30394321
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.29663704
121Tryptophan metabolism_Homo sapiens_hsa003800.29577581
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29509894
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29121458
124Butanoate metabolism_Homo sapiens_hsa006500.27632626
125Fanconi anemia pathway_Homo sapiens_hsa034600.27496104
126Salivary secretion_Homo sapiens_hsa049700.27397897
127mRNA surveillance pathway_Homo sapiens_hsa030150.26449456
128Calcium signaling pathway_Homo sapiens_hsa040200.26275436
129Cell cycle_Homo sapiens_hsa041100.25361223
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.24186634
131Sulfur relay system_Homo sapiens_hsa041220.22503298
132Hedgehog signaling pathway_Homo sapiens_hsa043400.22472354
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20249468
134Wnt signaling pathway_Homo sapiens_hsa043100.20100569
135Basal cell carcinoma_Homo sapiens_hsa052170.20088114
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19294399
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18444600

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