VAV3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57188798
2positive regulation by symbiont of host defense response (GO:0052509)5.01366820
3modulation by symbiont of host defense response (GO:0052031)5.01366820
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.01366820
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.01366820
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.01366820
7modulation by symbiont of host immune response (GO:0052553)5.01366820
8neutrophil activation involved in immune response (GO:0002283)4.70673037
9production of molecular mediator involved in inflammatory response (GO:0002532)4.57544274
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29448217
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29448217
12positive regulation of gamma-delta T cell activation (GO:0046645)4.21262188
13regulation of gamma-delta T cell differentiation (GO:0045586)4.20147750
14neutrophil mediated immunity (GO:0002446)4.11549175
15antigen processing and presentation of endogenous antigen (GO:0019883)4.11244147
16response to muramyl dipeptide (GO:0032495)4.10939443
17regulation of interferon-beta biosynthetic process (GO:0045357)4.08132559
18cellular response to interferon-beta (GO:0035458)4.07038074
19response to peptidoglycan (GO:0032494)3.99718883
20positive regulation of interferon-alpha production (GO:0032727)3.94825591
21regulation of B cell receptor signaling pathway (GO:0050855)3.89173963
22respiratory burst (GO:0045730)3.88279066
23immunoglobulin mediated immune response (GO:0016064)3.77676782
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.74722051
25regulation of interferon-alpha production (GO:0032647)3.73468953
26positive regulation of antigen processing and presentation (GO:0002579)3.70370174
27negative regulation of phagocytosis (GO:0050765)3.65651121
28negative regulation of cell killing (GO:0031342)3.65111807
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65111807
30neutrophil activation (GO:0042119)3.63936126
31positive regulation of B cell differentiation (GO:0045579)3.61029344
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53294513
33macrophage activation involved in immune response (GO:0002281)3.52186557
34detection of bacterium (GO:0016045)3.50006947
35response to host immune response (GO:0052572)3.44619447
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44619447
37granulocyte activation (GO:0036230)3.43762158
38detection of molecule of bacterial origin (GO:0032490)3.41148213
39cellular extravasation (GO:0045123)3.37780207
40definitive hemopoiesis (GO:0060216)3.33576656
41positive regulation of mast cell activation involved in immune response (GO:0033008)3.33245072
42positive regulation of mast cell degranulation (GO:0043306)3.33245072
43response to interferon-beta (GO:0035456)3.32619946
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31021410
45pinocytosis (GO:0006907)3.30467499
46regulation of interleukin-12 biosynthetic process (GO:0045075)3.30083899
47myeloid cell activation involved in immune response (GO:0002275)3.29821927
48detection of external biotic stimulus (GO:0098581)3.27651356
49superoxide anion generation (GO:0042554)3.26274903
50negative regulation of B cell proliferation (GO:0030889)3.25771949
51myeloid dendritic cell activation (GO:0001773)3.25683167
52NIK/NF-kappaB signaling (GO:0038061)3.25655345
53B cell homeostasis (GO:0001782)3.25252852
54antigen processing and presentation via MHC class Ib (GO:0002475)3.24651955
55response to host (GO:0075136)3.23721686
56response to host defenses (GO:0052200)3.23721686
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23721686
58myeloid leukocyte mediated immunity (GO:0002444)3.23113418
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.18853722
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16150642
61negative regulation of interleukin-12 production (GO:0032695)3.14436824
62defense response to protozoan (GO:0042832)3.13239385
63B cell mediated immunity (GO:0019724)3.11892269
64negative regulation of erythrocyte differentiation (GO:0045647)3.11568658
65positive regulation of interleukin-1 beta secretion (GO:0050718)3.09683422
66positive regulation of granulocyte differentiation (GO:0030854)3.08691953
67interferon-gamma-mediated signaling pathway (GO:0060333)3.06376764
68regulation of female gonad development (GO:2000194)3.06290613
69leukocyte aggregation (GO:0070486)3.05940178
70type I interferon signaling pathway (GO:0060337)3.03811725
71cellular response to type I interferon (GO:0071357)3.03811725
72response to type I interferon (GO:0034340)3.03429264
73thrombin receptor signaling pathway (GO:0070493)3.03363620
74response to protozoan (GO:0001562)3.01028466
75regulation of antigen processing and presentation (GO:0002577)2.98492276
76regulation of B cell differentiation (GO:0045577)2.96605775
77negative regulation of T cell mediated immunity (GO:0002710)2.94454331
78regulation of mast cell activation (GO:0033003)2.94370978
79protein K11-linked deubiquitination (GO:0035871)2.93365839
80negative regulation of T-helper cell differentiation (GO:0045623)2.93057110
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93057110
82negative regulation of lymphocyte mediated immunity (GO:0002707)2.93022681
83leukocyte mediated cytotoxicity (GO:0001909)2.92694952
84macrophage activation (GO:0042116)2.91971412
85response to interferon-alpha (GO:0035455)2.91542432
86regulation of mast cell degranulation (GO:0043304)2.87706195
87positive regulation of interferon-beta production (GO:0032728)2.87443535
88actin nucleation (GO:0045010)2.87192744
89regulation of leukocyte degranulation (GO:0043300)2.86768722
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86455367
91natural killer cell mediated immunity (GO:0002228)2.86446768
92natural killer cell mediated cytotoxicity (GO:0042267)2.86446768
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85879157
94detection of biotic stimulus (GO:0009595)2.84415421
95positive regulation of mast cell activation (GO:0033005)2.84364746
96negative regulation of interleukin-17 production (GO:0032700)2.83733937
97establishment of skin barrier (GO:0061436)2.83312093
98microglial cell activation (GO:0001774)2.82731171
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82703655
100interferon-gamma production (GO:0032609)2.82591036
101hepatocyte apoptotic process (GO:0097284)2.82017539
102positive regulation of interleukin-1 secretion (GO:0050716)2.81870501
103mast cell activation (GO:0045576)2.81281998
104myeloid leukocyte activation (GO:0002274)2.80297284
105lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80164671
106germinal center formation (GO:0002467)2.79775465
107regulation of hypersensitivity (GO:0002883)2.78815122
108regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.77289919
109positive regulation of leukocyte degranulation (GO:0043302)2.76485533
110negative regulation of interleukin-8 production (GO:0032717)2.75855586
111positive thymic T cell selection (GO:0045059)2.74674984
112phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.74290492
113regulation of interleukin-1 beta secretion (GO:0050706)2.73978221
114positive regulation of macrophage differentiation (GO:0045651)2.73952207
115regulation of interleukin-8 biosynthetic process (GO:0045414)2.72832146
116regulation of T-helper 1 cell differentiation (GO:0045625)2.72398799
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71602739
118detection of other organism (GO:0098543)2.70913521
119regulation of tolerance induction (GO:0002643)2.70791060
120phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69993427
121positive regulation of cellular amide metabolic process (GO:0034250)2.69564880
122* B cell receptor signaling pathway (GO:0050853)2.69235836
123regulation of mast cell activation involved in immune response (GO:0033006)2.69090630
124T cell homeostasis (GO:0043029)2.68809103
125positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.68016642
126cellular response to zinc ion (GO:0071294)2.67329446
127modulation of growth of symbiont involved in interaction with host (GO:0044144)2.67267677
128regulation of growth of symbiont in host (GO:0044126)2.67267677
129negative regulation of growth of symbiont in host (GO:0044130)2.67267677
130negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.67267677
131activated T cell proliferation (GO:0050798)2.67227363
132regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.66922862
133regulation of germinal center formation (GO:0002634)2.66870796
134myeloid dendritic cell differentiation (GO:0043011)2.66428015
135regulation of RIG-I signaling pathway (GO:0039535)2.65857853
136cytokine secretion (GO:0050663)2.65760394
137regulation of gamma-delta T cell activation (GO:0046643)2.62973366
138T-helper cell differentiation (GO:0042093)2.61527064
139CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.61527064
140G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.61328899
141cellular response to ethanol (GO:0071361)2.58411534
142negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.57046620
143dendritic cell migration (GO:0036336)2.56347872
144regulation of water loss via skin (GO:0033561)2.56097105
145piRNA metabolic process (GO:0034587)2.55702313
146negative regulation of granulocyte differentiation (GO:0030853)2.55631097
147oocyte development (GO:0048599)2.53229136
148response to interleukin-15 (GO:0070672)2.52264727
149negative thymic T cell selection (GO:0045060)2.51879579
150regulation of granulocyte differentiation (GO:0030852)2.51407595
151positive regulation of regulated secretory pathway (GO:1903307)2.51002303
152megakaryocyte development (GO:0035855)2.45981578

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.74290608
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.21982130
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.57564533
4E2F7_22180533_ChIP-Seq_HELA_Human4.28177904
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.15995937
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.12880380
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.97655132
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.96487303
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.83719158
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.81807463
11* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.79419050
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.65738836
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43553621
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.23196862
15SCL_19346495_ChIP-Seq_HPC-7_Human3.22550317
16ESR1_20079471_ChIP-ChIP_T-47D_Human3.08515391
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.03293953
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00603046
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.81190055
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57489877
21SPI1_23547873_ChIP-Seq_NB4_Human2.50280569
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.38314315
23* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.27620883
24MYB_26560356_Chip-Seq_TH2_Human2.21548753
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21360909
26VDR_24763502_ChIP-Seq_THP-1_Human2.17261747
27VDR_21846776_ChIP-Seq_THP-1_Human2.15717190
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14931557
29* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12892944
30RUNX_20019798_ChIP-Seq_JUKART_Human2.06495895
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01016046
32SPI1_23127762_ChIP-Seq_K562_Human1.99400971
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.98559413
34PU_27001747_Chip-Seq_BMDM_Mouse1.96948282
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96322170
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.95538531
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86916185
38MYB_26560356_Chip-Seq_TH1_Human1.85308636
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84826555
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81939092
41* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79073003
42MAF_26560356_Chip-Seq_TH1_Human1.73818237
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71622552
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70063671
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65864365
46VDR_24787735_ChIP-Seq_THP-1_Human1.59975108
47* GATA2_21666600_ChIP-Seq_HMVEC_Human1.58382980
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57449744
49* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54935060
50MYC_22102868_ChIP-Seq_BL_Human1.53524195
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51876705
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.45157404
53AHR_22903824_ChIP-Seq_MCF-7_Human1.43796918
54TCF7_22412390_ChIP-Seq_EML_Mouse1.41227666
55GATA1_22025678_ChIP-Seq_K562_Human1.39927561
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.39696216
57UTX_26944678_Chip-Seq_JUKART_Human1.38031166
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.37137293
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36065090
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35316635
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34921888
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34762693
63GATA3_27048872_Chip-Seq_THYMUS_Human1.33440688
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32421076
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.31009706
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29473223
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28207625
68* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27402840
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27161105
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26965543
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.26361801
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26006593
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25587375
74* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23053483
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21296993
76GATA3_26560356_Chip-Seq_TH2_Human1.20953806
77* SMRT_27268052_Chip-Seq_Bcells_Human1.20371588
78* GATA2_19941826_ChIP-Seq_K562_Human1.19339565
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19307337
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17021077
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15809997
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15266680
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15135519
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15001079
85* ER_23166858_ChIP-Seq_MCF-7_Human1.12675810
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09812905
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09282899
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08963711
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07588332
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07496982
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.06166109
92* GATA1_19941826_ChIP-Seq_K562_Human1.05192310
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04224347
94* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03989209
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02849422
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02388395
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00818664
98CDX2_22108803_ChIP-Seq_LS180_Human0.99251977
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98943726
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98601894
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97430465
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95863678
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94878548
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94636088
105* TP63_23658742_ChIP-Seq_EP156T_Human0.94463249
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93968400
107GATA4_25053715_ChIP-Seq_YYC3_Human0.93391039
108ELF5_23300383_ChIP-Seq_T47D_Human0.92680452
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.91350766
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90396760
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.89116183
112RXR_22108803_ChIP-Seq_LS180_Human0.89076784
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88758412
114SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88758412
115* CEBPB_22108803_ChIP-Seq_LS180_Human0.88751620
116GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88367800
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.88341391
118* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86428353
119ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86247853
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84323043
121ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83355061
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82852149
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82097827
124* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82020012
125MAF_26560356_Chip-Seq_TH2_Human0.81998494
126* GATA6_25053715_ChIP-Seq_YYC3_Human0.81358214
127E2F1_21310950_ChIP-Seq_MCF-7_Human0.81274248
128BCAT_22108803_ChIP-Seq_LS180_Human0.81105198
129* PRDM14_20953172_ChIP-Seq_ESCs_Human0.81019716
130* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80899011
131* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80743633
132* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79721047
133LXR_22158963_ChIP-Seq_LIVER_Mouse0.78128538
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75686893
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74614595
136* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74216374
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72623313
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.71933106
139TFEB_21752829_ChIP-Seq_HELA_Human0.71376233
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71167153
141ELK1_19687146_ChIP-ChIP_HELA_Human0.68613972
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67974595
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.66599970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.47576432
2MP0001835_abnormal_antigen_presentation4.29585246
3MP0003436_decreased_susceptibility_to3.27158525
4MP0009785_altered_susceptibility_to3.02060082
5MP0002148_abnormal_hypersensitivity_rea2.96771816
6MP0002419_abnormal_innate_immunity2.90930753
7MP0010234_abnormal_vibrissa_follicle2.83506382
8MP0005000_abnormal_immune_tolerance2.78845281
9MP0000685_abnormal_immune_system2.71904107
10MP0003303_peritoneal_inflammation2.68201665
11MP0005025_abnormal_response_to2.66717004
12MP0002452_abnormal_antigen_presenting2.50837885
13MP0009278_abnormal_bone_marrow2.48693482
14MP0005671_abnormal_response_to2.47366091
15MP0005174_abnormal_tail_pigmentation2.46331994
16MP0005387_immune_system_phenotype2.44416720
17MP0001790_abnormal_immune_system2.44416720
18MP0002396_abnormal_hematopoietic_system2.42794503
19MP0001800_abnormal_humoral_immune2.42370681
20MP0002166_altered_tumor_susceptibility2.30540571
21MP0002723_abnormal_immune_serum2.29073030
22MP0001819_abnormal_immune_cell2.28305252
23MP0002420_abnormal_adaptive_immunity2.27607548
24MP0005397_hematopoietic_system_phenotyp2.26467193
25MP0001545_abnormal_hematopoietic_system2.26467193
26MP0005464_abnormal_platelet_physiology2.24265662
27MP0002006_tumorigenesis2.16545555
28MP0003724_increased_susceptibility_to2.16084333
29MP0002138_abnormal_hepatobiliary_system2.12905199
30MP0004808_abnormal_hematopoietic_stem2.11937605
31MP0004264_abnormal_extraembryonic_tissu2.09104377
32MP0005058_abnormal_lysosome_morphology2.04840010
33MP0004043_abnormal_pH_regulation2.03650936
34MP0004381_abnormal_hair_follicle1.95154510
35MP0002398_abnormal_bone_marrow1.90170564
36MP0003172_abnormal_lysosome_physiology1.89394006
37MP0001853_heart_inflammation1.88436033
38MP0002405_respiratory_system_inflammati1.86159292
39MP0002796_impaired_skin_barrier1.84896417
40MP0003300_gastrointestinal_ulcer1.83735951
41MP0004510_myositis1.81709462
42MP0000716_abnormal_immune_system1.77107821
43MP0004947_skin_inflammation1.73025012
44MP0005075_abnormal_melanosome_morpholog1.72868595
45MP0010678_abnormal_skin_adnexa1.72507964
46MP0010155_abnormal_intestine_physiology1.71548005
47MP0003763_abnormal_thymus_physiology1.70781115
48MP0000465_gastrointestinal_hemorrhage1.69110758
49MP0003195_calcinosis1.68272872
50MP0006082_CNS_inflammation1.66096934
51MP0001533_abnormal_skeleton_physiology1.63958357
52MP0003448_altered_tumor_morphology1.63642023
53MP0001845_abnormal_inflammatory_respons1.56009779
54MP0000689_abnormal_spleen_morphology1.55570883
55MP0002429_abnormal_blood_cell1.47898930
56MP0002722_abnormal_immune_system1.46232155
57MP0000490_abnormal_crypts_of1.43789429
58MP0000858_altered_metastatic_potential1.39649565
59MP0000343_altered_response_to1.38812279
60MP0000427_abnormal_hair_cycle1.36456918
61MP0010307_abnormal_tumor_latency1.34274208
62MP0001873_stomach_inflammation1.34217329
63MP0009764_decreased_sensitivity_to1.32652815
64MP0001765_abnormal_ion_homeostasis1.28957121
65MP0000015_abnormal_ear_pigmentation1.26194113
66MP0003075_altered_response_to1.25757204
67MP0002132_abnormal_respiratory_system1.22997720
68MP0003252_abnormal_bile_duct1.22872975
69MP0005310_abnormal_salivary_gland1.20029168
70MP0009333_abnormal_splenocyte_physiolog1.20024817
71MP0002095_abnormal_skin_pigmentation1.18082316
72MP0003566_abnormal_cell_adhesion1.17749527
73MP0002139_abnormal_hepatobiliary_system1.16687412
74MP0001851_eye_inflammation1.14505554
75MP0003828_pulmonary_edema1.12847501
76* MP0008469_abnormal_protein_level1.12682506
77MP0000703_abnormal_thymus_morphology1.12184412
78MP0002098_abnormal_vibrissa_morphology1.11408786
79MP0008007_abnormal_cellular_replicative1.11121499
80MP0005076_abnormal_cell_differentiation1.09810365
81MP0002998_abnormal_bone_remodeling1.04420835
82MP0009379_abnormal_foot_pigmentation1.04313101
83MP0005083_abnormal_biliary_tract1.01704794
84MP0005409_darkened_coat_color0.99125823
85MP0008877_abnormal_DNA_methylation0.96001575
86MP0002933_joint_inflammation0.95259536
87MP0005647_abnormal_sex_gland0.90594512
88MP0000371_diluted_coat_color0.90586630
89MP0003656_abnormal_erythrocyte_physiolo0.90128951
90MP0003866_abnormal_defecation0.89670760
91MP0003045_fibrosis0.89661946
92MP0006054_spinal_hemorrhage0.88617876
93MP0003638_abnormal_response/metabolism_0.88261465
94MP0001663_abnormal_digestive_system0.86426338
95MP0002254_reproductive_system_inflammat0.86285533
96MP0000383_abnormal_hair_follicle0.84362079
97MP0001919_abnormal_reproductive_system0.83989846
98MP0005390_skeleton_phenotype0.82332204
99MP0004883_abnormal_blood_vessel0.81231940
100MP0008260_abnormal_autophagy0.79722316
101MP0005166_decreased_susceptibility_to0.78704596
102MP0005501_abnormal_skin_physiology0.78449432
103MP0010352_gastrointestinal_tract_polyps0.78271536
104MP0005085_abnormal_gallbladder_physiolo0.77970185
105* MP0003183_abnormal_peptide_metabolism0.77683546
106MP0008875_abnormal_xenobiotic_pharmacok0.77556034
107MP0005360_urolithiasis0.77434624
108MP0000377_abnormal_hair_follicle0.76667644
109MP0002019_abnormal_tumor_incidence0.75494164
110MP0004019_abnormal_vitamin_homeostasis0.72901368
111MP0009643_abnormal_urine_homeostasis0.72844643
112MP0004782_abnormal_surfactant_physiolog0.72554988
113MP0002277_abnormal_respiratory_mucosa0.72057332
114MP0002163_abnormal_gland_morphology0.71974391
115MP0003091_abnormal_cell_migration0.71908989
116MP0002009_preneoplasia0.71185221
117MP0003795_abnormal_bone_structure0.70663324
118MP0005164_abnormal_response_to0.69900707
119MP0009763_increased_sensitivity_to0.66206316
120MP0003943_abnormal_hepatobiliary_system0.65921158
121MP0000249_abnormal_blood_vessel0.61424196
122MP0001958_emphysema0.59832726
123MP0005167_abnormal_blood-brain_barrier0.59450311
124MP0001191_abnormal_skin_condition0.59031224
125MP0010094_abnormal_chromosome_stability0.55664602
126MP0001986_abnormal_taste_sensitivity0.54824153
127MP0003191_abnormal_cellular_cholesterol0.54804955
128MP0001216_abnormal_epidermal_layer0.54558827
129MP0002075_abnormal_coat/hair_pigmentati0.53134482
130MP0001346_abnormal_lacrimal_gland0.53016138
131MP0003077_abnormal_cell_cycle0.52972573
132MP0002060_abnormal_skin_morphology0.52292651
133MP0008057_abnormal_DNA_replication0.52155151

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.29278692
2Recurrent bacterial skin infections (HP:0005406)5.71270472
3Eczematoid dermatitis (HP:0000976)5.52937450
4Myositis (HP:0100614)5.00937623
5Elevated erythrocyte sedimentation rate (HP:0003565)4.62628855
6Hyperactive renin-angiotensin system (HP:0000841)4.29575938
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.27420804
8Orchitis (HP:0100796)4.11296960
9Retrobulbar optic neuritis (HP:0100654)3.99718362
10Optic neuritis (HP:0100653)3.99718362
11Mediastinal lymphadenopathy (HP:0100721)3.90046274
12Recurrent fungal infections (HP:0002841)3.89140672
13Recurrent skin infections (HP:0001581)3.81127708
14Thrombocytosis (HP:0001894)3.78796768
15Recurrent gram-negative bacterial infections (HP:0005420)3.78639965
16Autoimmune thrombocytopenia (HP:0001973)3.72235328
17Abnormality of macrophages (HP:0004311)3.71593712
18Chronic otitis media (HP:0000389)3.59855940
19Recurrent viral infections (HP:0004429)3.54900808
20Recurrent cutaneous fungal infections (HP:0011370)3.49662719
21Chronic mucocutaneous candidiasis (HP:0002728)3.49662719
22Obstructive lung disease (HP:0006536)3.47931862
23Chronic obstructive pulmonary disease (HP:0006510)3.47931862
24Vasculitis (HP:0002633)3.33358270
25Periodontitis (HP:0000704)3.29504388
26Gingivitis (HP:0000230)3.28906554
27Cellulitis (HP:0100658)3.13394304
28Abnormality of chloride homeostasis (HP:0011422)3.09771426
29Stomatitis (HP:0010280)3.07800122
30Decreased circulating renin level (HP:0003351)2.99765301
31Meningitis (HP:0001287)2.99424261
32Prostate neoplasm (HP:0100787)2.97649894
33Abnormality of T cell physiology (HP:0011840)2.97272480
34Arterial thrombosis (HP:0004420)2.97197676
35Metabolic alkalosis (HP:0200114)2.96956864
36Keratoconjunctivitis sicca (HP:0001097)2.90816228
37Abnormality of B cell number (HP:0010975)2.88307495
38Vacuolated lymphocytes (HP:0001922)2.87420249
39Abnormality of renin-angiotensin system (HP:0000847)2.87368316
40Disinhibition (HP:0000734)2.83938273
41Abnormality of the prostate (HP:0008775)2.79969029
42Increased cerebral lipofuscin (HP:0011813)2.78450356
43Keratoconjunctivitis (HP:0001096)2.66635735
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.64162639
45Pulmonary infiltrates (HP:0002113)2.63304441
46Albinism (HP:0001022)2.62470052
47Thick nail (HP:0001805)2.60869261
48Osteomyelitis (HP:0002754)2.59475208
49Absent/shortened dynein arms (HP:0200106)2.59179054
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.59179054
51Abnormality of T cell number (HP:0011839)2.55483820
52Hematochezia (HP:0002573)2.54727499
53Hypokalemic alkalosis (HP:0001949)2.53446680
54Hyperaldosteronism (HP:0000859)2.53259358
55IgM deficiency (HP:0002850)2.52286894
56Stomach cancer (HP:0012126)2.49821779
57Gastrointestinal infarctions (HP:0005244)2.47718706
58Eosinophilia (HP:0001880)2.47286476
59Absent frontal sinuses (HP:0002688)2.44262867
60B lymphocytopenia (HP:0010976)2.42753734
61Lip pit (HP:0100267)2.41549825
62Spontaneous hematomas (HP:0007420)2.37649869
63Leukocytosis (HP:0001974)2.37199563
64Interstitial pulmonary disease (HP:0006530)2.36550550
65Pustule (HP:0200039)2.32558801
66Abnormality of T cells (HP:0002843)2.31722331
67Recurrent pneumonia (HP:0006532)2.31148536
68Neoplasm of the tracheobronchial system (HP:0100552)2.30110047
69Increased circulating renin level (HP:0000848)2.29553024
70Petechiae (HP:0000967)2.29423737
71Hypergammaglobulinemia (HP:0010702)2.29366892
72Recurrent bronchitis (HP:0002837)2.29131455
73Urticaria (HP:0001025)2.27951889
74Chronic sinusitis (HP:0011109)2.27798182
75Chest pain (HP:0100749)2.27624528
76Hemoptysis (HP:0002105)2.24617713
77Inflammation of the large intestine (HP:0002037)2.23719162
78Bronchitis (HP:0012387)2.23462536
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23197149
80Basal ganglia calcification (HP:0002135)2.20626031
81Thyroiditis (HP:0100646)2.20441927
82Alveolar cell carcinoma (HP:0006519)2.18074052
83T lymphocytopenia (HP:0005403)2.17664144
84Prolonged bleeding time (HP:0003010)2.17582645
85Increased IgE level (HP:0003212)2.17290144
86Colitis (HP:0002583)2.14611935
87Abnormality of the axillary hair (HP:0100134)2.12640862
88Abnormality of secondary sexual hair (HP:0009888)2.12640862
89Chronic diarrhea (HP:0002028)2.12602334
90Pulmonary embolism (HP:0002204)2.12040779
91Abnormality of the lumbar spine (HP:0100712)2.11942578
92Acute lymphatic leukemia (HP:0006721)2.11568605
93Abnormality of the pleura (HP:0002103)2.10539942
94Gastrointestinal inflammation (HP:0004386)2.09775607
95Acute myeloid leukemia (HP:0004808)2.07572346
96Granulocytopenia (HP:0001913)2.06385837
97Alkalosis (HP:0001948)2.05747360
98Skin ulcer (HP:0200042)2.05668743
99Recurrent lower respiratory tract infections (HP:0002783)2.04488044
100Encephalitis (HP:0002383)2.03978230
101Curly hair (HP:0002212)2.02693520
102Sepsis (HP:0100806)2.01254576
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.00123453
104Abnormal ciliary motility (HP:0012262)1.99384469
105Papilledema (HP:0001085)1.98770191
106Abnormality of glycosphingolipid metabolism (HP:0004343)1.98438051
107Abnormality of glycolipid metabolism (HP:0010969)1.98438051
108Abnormality of liposaccharide metabolism (HP:0010968)1.98438051
109Osteolytic defects of the hand bones (HP:0009699)1.98321227
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.98321227
111Increased IgM level (HP:0003496)1.98114166
112Panhypogammaglobulinemia (HP:0003139)1.97888481
113Inappropriate behavior (HP:0000719)1.96224880
114IgG deficiency (HP:0004315)1.96049269
115Abnormality of eosinophils (HP:0001879)1.95295677
116Chronic bronchitis (HP:0004469)1.95206797
117Loss of speech (HP:0002371)1.95093223
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94865818
119Cone-rod dystrophy (HP:0000548)1.94145990
120Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93891515
121Premature loss of primary teeth (HP:0006323)1.93114755
122Gingival bleeding (HP:0000225)1.92459044
123Abnormality of the thoracic spine (HP:0100711)1.92278448
124Bronchiectasis (HP:0002110)1.89417264
125Agammaglobulinemia (HP:0004432)1.88787219
126Dysostosis multiplex (HP:0000943)1.88559684
127Autoimmune hemolytic anemia (HP:0001890)1.88215605
128Gangrene (HP:0100758)1.87969901
129Hyperkalemia (HP:0002153)1.87245123
130Systemic lupus erythematosus (HP:0002725)1.87048263
131Lymphopenia (HP:0001888)1.86640088
132Abnormality of the fingertips (HP:0001211)1.86220808
133Thoracic kyphosis (HP:0002942)1.85709601
134Recurrent sinusitis (HP:0011108)1.85372221
135Papillary thyroid carcinoma (HP:0002895)1.84600790
136Tetany (HP:0001281)1.84196173
137Spinal cord lesions (HP:0100561)1.83299205
138Syringomyelia (HP:0003396)1.83299205
139Epistaxis (HP:0000421)1.81906043
140Deformed sella turcica (HP:0002681)1.80378459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.70255491
2KIT3.31483410
3MAP4K12.93124271
4IRAK42.83459047
5TBK12.71027750
6TYK22.45204362
7JAK32.42831747
8TEC2.42213264
9RIPK42.36998895
10IKBKE2.24368212
11FES2.20592415
12BTK2.19841037
13OXSR12.13268309
14TXK1.99368033
15IKBKB1.92978800
16CSF1R1.89590392
17SIK31.86560768
18BLK1.75911693
19SYK1.68233590
20HCK1.66829691
21TGFBR21.63230004
22CHUK1.62543883
23IRAK31.55235513
24MAP3K21.54218587
25FGFR31.54136496
26PIM21.49457135
27INSRR1.48392296
28IRAK11.47271432
29JAK11.44770255
30CLK11.42038853
31MAP2K31.41423547
32EPHB11.40423864
33STK101.38604385
34PIK3CG1.37914368
35TRPM71.35329661
36ERBB31.32874422
37TAOK31.30065782
38ZAP701.28783603
39LYN1.25565711
40MAP3K11.24913248
41FER1.24570819
42LCK1.22933554
43WNK31.19693468
44NME21.19333163
45ITK1.19188614
46CSK1.18508969
47MAPKAPK31.17249290
48MATK1.16860891
49MKNK11.16176024
50NUAK11.12576645
51RPS6KB21.11504755
52RPS6KA41.11440852
53CDK61.10193784
54PIM11.09082366
55STK391.08185837
56FLT31.05268166
57CDK121.04662533
58EIF2AK11.04000368
59ERN11.00442674
60NEK61.00006331
61SIK20.99955420
62LATS10.98947373
63EEF2K0.95069949
64EIF2AK20.90596669
65LRRK20.90455034
66SCYL20.89301251
67MAP3K120.87925680
68STK40.85794961
69RIPK10.85781373
70YES10.84600390
71JAK20.84550893
72PIK3CA0.83258126
73TTN0.81584511
74BRSK20.80737500
75MST40.79771832
76FGFR40.78595407
77MARK30.78058277
78SGK20.77627333
79PDK10.77288960
80BMPR20.77079062
81MAP3K130.74742081
82EIF2AK30.74630260
83TIE10.73561858
84PRKCQ0.71015933
85TGFBR10.67571859
86ABL10.65439413
87PTK60.64369934
88NEK90.64141393
89PAK40.63905060
90STK30.62571551
91TAOK10.60914493
92PRPF4B0.60778984
93PRKCD0.60436064
94HIPK20.60011449
95GRK60.59216791
96CAMKK20.58323993
97TNIK0.58108602
98WNK10.57627857
99MAP3K60.56786350
100MAPKAPK50.56607180
101ADRBK20.56453102
102RPS6KA60.56060985
103CAMK1D0.55876304
104SGK30.53756463
105FGR0.53701188
106EGFR0.53422929
107NLK0.52731838
108ATR0.52401468
109GRK70.51768592
110STK240.51310862
111PRKAA20.50603651
112MARK20.49099204
113MAP2K20.48436562
114TNK20.48411775
115MOS0.48279375
116MAP3K50.47465161
117PKN20.47152747
118MAPK110.47073487
119PRKG20.45143028
120PDPK10.45113985
121MAPK40.44909791
122ACVR1B0.44259854
123MAPKAPK20.43911392
124ERBB20.43387288
125RPS6KC10.41950126
126RPS6KL10.41950126
127DYRK1B0.41470977
128MAP3K70.41157934
129RPS6KB10.40685015
130MAP3K30.40498483
131MKNK20.39697227
132CDK40.38571571
133EPHA30.38411935
134MAP2K60.37586649
135IGF1R0.37547329
136FRK0.37431815
137BRD40.35116020
138IRAK20.35104787
139MAPK70.33377907
140MAPK30.29884915
141FYN0.29332292

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.07358021
2Osteoclast differentiation_Homo sapiens_hsa043802.38602212
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31626803
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.28068664
5Measles_Homo sapiens_hsa051622.15762245
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15666742
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02850252
8Legionellosis_Homo sapiens_hsa051342.02214941
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96835903
10Pertussis_Homo sapiens_hsa051331.95478666
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94289746
12Allograft rejection_Homo sapiens_hsa053301.93557191
13Tuberculosis_Homo sapiens_hsa051521.84526160
14* B cell receptor signaling pathway_Homo sapiens_hsa046621.82406285
15Dorso-ventral axis formation_Homo sapiens_hsa043201.80839160
16Malaria_Homo sapiens_hsa051441.78818688
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.74920895
18Graft-versus-host disease_Homo sapiens_hsa053321.69743220
19Influenza A_Homo sapiens_hsa051641.69316678
20TNF signaling pathway_Homo sapiens_hsa046681.67524526
21Toxoplasmosis_Homo sapiens_hsa051451.67284700
22Antigen processing and presentation_Homo sapiens_hsa046121.64693280
23Herpes simplex infection_Homo sapiens_hsa051681.63140375
24* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61968176
25Primary immunodeficiency_Homo sapiens_hsa053401.61842016
26Shigellosis_Homo sapiens_hsa051311.58655806
27Hematopoietic cell lineage_Homo sapiens_hsa046401.53952446
28Salmonella infection_Homo sapiens_hsa051321.48231830
29Staphylococcus aureus infection_Homo sapiens_hsa051501.48166947
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47263459
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.45342501
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44553268
33Phagosome_Homo sapiens_hsa041451.43043775
34* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41329232
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39425400
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.36061481
37Apoptosis_Homo sapiens_hsa042101.35752348
38Hepatitis B_Homo sapiens_hsa051611.34103559
39Other glycan degradation_Homo sapiens_hsa005111.28815402
40* Chemokine signaling pathway_Homo sapiens_hsa040621.28400227
41* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26129616
42African trypanosomiasis_Homo sapiens_hsa051431.25287265
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25273430
44* Leukocyte transendothelial migration_Homo sapiens_hsa046701.24930784
45Nitrogen metabolism_Homo sapiens_hsa009101.24617526
46Asthma_Homo sapiens_hsa053101.21492397
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18600566
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18136956
49Rheumatoid arthritis_Homo sapiens_hsa053231.17325383
50Lysosome_Homo sapiens_hsa041421.17257381
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16471268
52Viral myocarditis_Homo sapiens_hsa054161.16442494
53Platelet activation_Homo sapiens_hsa046111.12008175
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11299077
55Chronic myeloid leukemia_Homo sapiens_hsa052201.08935025
56Linoleic acid metabolism_Homo sapiens_hsa005911.07883883
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99364324
58Pancreatic cancer_Homo sapiens_hsa052120.96328402
59Acute myeloid leukemia_Homo sapiens_hsa052210.95647626
60Hepatitis C_Homo sapiens_hsa051600.94207035
61Ether lipid metabolism_Homo sapiens_hsa005650.93131499
62Arachidonic acid metabolism_Homo sapiens_hsa005900.91170356
63Type I diabetes mellitus_Homo sapiens_hsa049400.89550571
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89502107
65* T cell receptor signaling pathway_Homo sapiens_hsa046600.89299441
66Small cell lung cancer_Homo sapiens_hsa052220.88489332
67Sphingolipid metabolism_Homo sapiens_hsa006000.87636335
68Histidine metabolism_Homo sapiens_hsa003400.87117962
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.86630060
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.85588870
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85049889
72Autoimmune thyroid disease_Homo sapiens_hsa053200.85036599
73p53 signaling pathway_Homo sapiens_hsa041150.84254469
74DNA replication_Homo sapiens_hsa030300.83914582
75Base excision repair_Homo sapiens_hsa034100.82812608
76Prolactin signaling pathway_Homo sapiens_hsa049170.81982140
77Non-homologous end-joining_Homo sapiens_hsa034500.81727981
78ABC transporters_Homo sapiens_hsa020100.76716675
79Epstein-Barr virus infection_Homo sapiens_hsa051690.74726015
80Amoebiasis_Homo sapiens_hsa051460.74554893
81Viral carcinogenesis_Homo sapiens_hsa052030.74438181
82Ovarian steroidogenesis_Homo sapiens_hsa049130.72299718
83Caffeine metabolism_Homo sapiens_hsa002320.71368729
84Pancreatic secretion_Homo sapiens_hsa049720.68330799
85Choline metabolism in cancer_Homo sapiens_hsa052310.66658845
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65625537
87HTLV-I infection_Homo sapiens_hsa051660.63540587
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63454144
89Non-small cell lung cancer_Homo sapiens_hsa052230.63042130
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63032676
91MicroRNAs in cancer_Homo sapiens_hsa052060.61823962
92Homologous recombination_Homo sapiens_hsa034400.61749125
93Renal cell carcinoma_Homo sapiens_hsa052110.59962218
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.55647611
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.55456617
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54154281
97Renin-angiotensin system_Homo sapiens_hsa046140.53334234
98Proteoglycans in cancer_Homo sapiens_hsa052050.50837794
99Endometrial cancer_Homo sapiens_hsa052130.50662120
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50454223
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50206119
102Insulin resistance_Homo sapiens_hsa049310.49274689
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.47760064
104VEGF signaling pathway_Homo sapiens_hsa043700.46959324
105Cell cycle_Homo sapiens_hsa041100.46883348
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46658767
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45216893
108Long-term depression_Homo sapiens_hsa047300.44619410
109Mineral absorption_Homo sapiens_hsa049780.43841137
110HIF-1 signaling pathway_Homo sapiens_hsa040660.43702451
111Regulation of autophagy_Homo sapiens_hsa041400.43181374
112Prostate cancer_Homo sapiens_hsa052150.43142037
113Vitamin digestion and absorption_Homo sapiens_hsa049770.43064538
114Colorectal cancer_Homo sapiens_hsa052100.42131427
115GnRH signaling pathway_Homo sapiens_hsa049120.40125181
116Inositol phosphate metabolism_Homo sapiens_hsa005620.40076805
117Chemical carcinogenesis_Homo sapiens_hsa052040.39492836
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39065961
119Ribosome_Homo sapiens_hsa030100.38989495
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38517515
121Endocytosis_Homo sapiens_hsa041440.38014967
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37877194
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35178568
124* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34757336
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34476671
126Notch signaling pathway_Homo sapiens_hsa043300.34005909
127Fanconi anemia pathway_Homo sapiens_hsa034600.32843418
128FoxO signaling pathway_Homo sapiens_hsa040680.31956262
129Systemic lupus erythematosus_Homo sapiens_hsa053220.31682452
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29666514
131* Focal adhesion_Homo sapiens_hsa045100.29254088

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