VAV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfur amino acid catabolic process (GO:0000098)5.21963428
2cellular modified amino acid catabolic process (GO:0042219)4.91631286
3hemidesmosome assembly (GO:0031581)4.82923190
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.74671371
5urea cycle (GO:0000050)4.70901355
6urea metabolic process (GO:0019627)4.70901355
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.61310619
8L-phenylalanine catabolic process (GO:0006559)4.61310619
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.60982282
10L-phenylalanine metabolic process (GO:0006558)4.60982282
11coenzyme catabolic process (GO:0009109)4.50951567
12kynurenine metabolic process (GO:0070189)4.45367102
13aromatic amino acid family catabolic process (GO:0009074)4.40230251
14alpha-linolenic acid metabolic process (GO:0036109)4.37362997
15negative regulation of fibrinolysis (GO:0051918)4.26917410
16tryptophan catabolic process (GO:0006569)4.21892086
17indole-containing compound catabolic process (GO:0042436)4.21892086
18indolalkylamine catabolic process (GO:0046218)4.21892086
19nitrogen cycle metabolic process (GO:0071941)4.18612126
20cysteine metabolic process (GO:0006534)4.14724247
21daunorubicin metabolic process (GO:0044597)4.10165411
22polyketide metabolic process (GO:0030638)4.10165411
23doxorubicin metabolic process (GO:0044598)4.10165411
24hormone catabolic process (GO:0042447)4.09133250
25epoxygenase P450 pathway (GO:0019373)4.06247509
26complement activation, alternative pathway (GO:0006957)4.03103660
27high-density lipoprotein particle remodeling (GO:0034375)4.00506585
28tryptophan metabolic process (GO:0006568)3.94773334
29regulation of protein activation cascade (GO:2000257)3.92040607
30negative regulation of cholesterol transport (GO:0032375)3.91443414
31negative regulation of sterol transport (GO:0032372)3.91443414
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.89436731
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.86468891
34peptidyl-glutamic acid carboxylation (GO:0017187)3.83724595
35protein carboxylation (GO:0018214)3.83724595
36serine family amino acid catabolic process (GO:0009071)3.81820586
37semaphorin-plexin signaling pathway (GO:0071526)3.76598548
38glyoxylate metabolic process (GO:0046487)3.73629167
39regulation of fibrinolysis (GO:0051917)3.72629262
40COPI coating of Golgi vesicle (GO:0048205)3.70288413
41Golgi transport vesicle coating (GO:0048200)3.70288413
42regulation of complement activation (GO:0030449)3.69535401
43bile acid biosynthetic process (GO:0006699)3.68684542
44reverse cholesterol transport (GO:0043691)3.67509465
45complement activation, classical pathway (GO:0006958)3.66393657
46phospholipid efflux (GO:0033700)3.62389972
47regulation of cholesterol homeostasis (GO:2000188)3.58839668
48cell-substrate junction assembly (GO:0007044)3.58505633
49protein retention in ER lumen (GO:0006621)3.55403851
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54601304
51desmosome organization (GO:0002934)3.53564743
52regulation of triglyceride catabolic process (GO:0010896)3.51843183
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.50474539
54regulation of glucose import in response to insulin stimulus (GO:2001273)3.50456496
55dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.49736371
56plasma lipoprotein particle clearance (GO:0034381)3.46887083
57adherens junction assembly (GO:0034333)3.43928764
58phospholipid homeostasis (GO:0055091)3.43792338
59homocysteine metabolic process (GO:0050667)3.42962563
60regulation of NFAT protein import into nucleus (GO:0051532)3.42935871
61complement activation (GO:0006956)3.38194129
62regulation of cholesterol esterification (GO:0010872)3.37253565
63cell-substrate adherens junction assembly (GO:0007045)3.37220752
64focal adhesion assembly (GO:0048041)3.37220752
65lysine catabolic process (GO:0006554)3.36550317
66lysine metabolic process (GO:0006553)3.36550317
67primary alcohol catabolic process (GO:0034310)3.35916891
68cell-cell junction maintenance (GO:0045217)3.34967395
69glycine metabolic process (GO:0006544)3.34952402
70positive regulation of histone deacetylation (GO:0031065)3.33806498
71activation of Rac GTPase activity (GO:0032863)3.32315325
72plasma lipoprotein particle remodeling (GO:0034369)3.29775606
73protein-lipid complex remodeling (GO:0034368)3.29775606
74macromolecular complex remodeling (GO:0034367)3.29775606
75bile acid metabolic process (GO:0008206)3.27479547
76negative regulation of fatty acid transport (GO:2000192)3.25896527
77protein localization to endosome (GO:0036010)3.21318091
78dicarboxylic acid biosynthetic process (GO:0043650)3.19286885
79triglyceride homeostasis (GO:0070328)3.19201942
80acylglycerol homeostasis (GO:0055090)3.19201942
81cytoskeletal anchoring at plasma membrane (GO:0007016)3.18535601
82drug metabolic process (GO:0017144)3.16474146
83epithelial cell-cell adhesion (GO:0090136)3.15508882
84skin morphogenesis (GO:0043589)3.14745708
85heme transport (GO:0015886)3.14669903
86cofactor catabolic process (GO:0051187)3.13552801
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.13346919
88valine metabolic process (GO:0006573)3.13232711
89positive regulation of Cdc42 GTPase activity (GO:0043089)3.12717121
90bile acid and bile salt transport (GO:0015721)3.12486690
91basement membrane organization (GO:0071711)3.12132827
92cholesterol efflux (GO:0033344)3.11549943
93branching involved in mammary gland duct morphogenesis (GO:0060444)3.11521912
94alpha-amino acid catabolic process (GO:1901606)3.11133957
95ethanol oxidation (GO:0006069)3.10469911
96positive regulation of lipid catabolic process (GO:0050996)3.10462579
97glucose 6-phosphate metabolic process (GO:0051156)3.10414367
98plasma lipoprotein particle assembly (GO:0034377)3.08926752
99regulation of fatty acid beta-oxidation (GO:0031998)3.08427290
100cellular amino acid catabolic process (GO:0009063)3.07734415
101embryonic retina morphogenesis in camera-type eye (GO:0060059)3.06900803
102retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.05668262
103aromatic amino acid family metabolic process (GO:0009072)3.05510969
104protein-lipid complex assembly (GO:0065005)3.02876815
105apoptotic process involved in morphogenesis (GO:0060561)3.01918302
106cell adhesion mediated by integrin (GO:0033627)2.99835367
107amino-acid betaine metabolic process (GO:0006577)2.99651029
108maternal placenta development (GO:0001893)2.98277252
109protein activation cascade (GO:0072376)2.97779904
110serine family amino acid metabolic process (GO:0009069)2.97621971
111lipoprotein metabolic process (GO:0042157)2.95527714
112very-low-density lipoprotein particle assembly (GO:0034379)2.94877217
113ear development (GO:0043583)2.94418325
114heterochromatin organization (GO:0070828)2.92730404
115regulation of lipoprotein particle clearance (GO:0010984)2.91524585
116drug catabolic process (GO:0042737)2.89356060
117activation of MAPKKK activity (GO:0000185)2.85538654
118cholesterol homeostasis (GO:0042632)2.82521623
119low-density lipoprotein particle clearance (GO:0034383)2.82445561
120biotin metabolic process (GO:0006768)2.81137585
121tyrosine metabolic process (GO:0006570)2.80726940
122regulation of cholesterol biosynthetic process (GO:0045540)2.80528837
123flavonoid metabolic process (GO:0009812)2.79597744
124sterol homeostasis (GO:0055092)2.78907835
125positive regulation of triglyceride lipase activity (GO:0061365)2.78620883
126positive regulation of lipoprotein lipase activity (GO:0051006)2.78620883
127benzene-containing compound metabolic process (GO:0042537)2.77337939
128regulation of early endosome to late endosome transport (GO:2000641)2.77220002
129regulation of cholesterol storage (GO:0010885)2.75290800
130glutamate metabolic process (GO:0006536)2.74902445
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74279592
132indolalkylamine metabolic process (GO:0006586)2.74209209
133apoptotic cell clearance (GO:0043277)2.73966373
134surfactant homeostasis (GO:0043129)2.73851337
135L-ascorbic acid metabolic process (GO:0019852)2.72748956
136positive regulation of protein deacetylation (GO:0090312)2.71492432
137negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.70794801
138imidazole-containing compound metabolic process (GO:0052803)2.70466405
139paraxial mesoderm development (GO:0048339)2.69878402
140proline biosynthetic process (GO:0006561)2.67631808
141proline metabolic process (GO:0006560)2.61103950
142establishment of apical/basal cell polarity (GO:0035089)2.59419275
143epithelial cell differentiation involved in prostate gland development (GO:0060742)2.59378475
144regulation of bile acid biosynthetic process (GO:0070857)2.57591969
145endothelial cell chemotaxis (GO:0035767)2.57121065
146regulation of extracellular matrix disassembly (GO:0010715)2.56984695
147cell junction maintenance (GO:0034331)2.56643456
148insulin-like growth factor receptor signaling pathway (GO:0048009)2.55277154
149cellular response to prostaglandin stimulus (GO:0071379)2.55003859
150regulation of plasminogen activation (GO:0010755)2.54095163
151cellular response to virus (GO:0098586)2.50987664
152receptor catabolic process (GO:0032801)2.50684193
153positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.50209936
154modulation by symbiont of host cellular process (GO:0044068)2.50152583
155establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.49997149
156gap junction assembly (GO:0016264)2.48382279
157negative regulation of lipid transport (GO:0032369)2.47947690
158cellular response to epidermal growth factor stimulus (GO:0071364)2.47208387
159Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.45083628
160embryonic process involved in female pregnancy (GO:0060136)2.44554239
161establishment or maintenance of apical/basal cell polarity (GO:0035088)2.43084521
162establishment or maintenance of bipolar cell polarity (GO:0061245)2.43084521
163regulation of extracellular matrix organization (GO:1903053)2.40988197
164modulation by virus of host morphology or physiology (GO:0019048)2.40721019
165layer formation in cerebral cortex (GO:0021819)2.39997769
166intestinal cholesterol absorption (GO:0030299)2.39812271
167positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.38219990
168branching involved in salivary gland morphogenesis (GO:0060445)2.38090790
169skeletal muscle organ development (GO:0060538)2.37474463
170regulation of apoptotic cell clearance (GO:2000425)2.36575453
171diaphragm development (GO:0060539)2.36486354
172regulation of apoptotic process involved in morphogenesis (GO:1902337)2.36014311
173convergent extension (GO:0060026)2.35667083
174adherens junction organization (GO:0034332)2.35652449
175spliceosomal tri-snRNP complex assembly (GO:0000244)2.33518803
176intracellular estrogen receptor signaling pathway (GO:0030520)2.32484153
177stress fiber assembly (GO:0043149)2.32329830
178activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.32299985
179eye morphogenesis (GO:0048592)2.31929042
180cell migration in hindbrain (GO:0021535)2.31819344
181actin filament bundle organization (GO:0061572)2.30823095
182actin filament bundle assembly (GO:0051017)2.30823095
183negative regulation of cell size (GO:0045792)2.30773274
184positive regulation of hormone metabolic process (GO:0032352)2.30510812
185peptidyl-tyrosine autophosphorylation (GO:0038083)2.30388276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.22568311
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.16422545
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.53976415
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.31160789
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.69120609
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.27379666
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.27379666
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.27379666
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02394649
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85233103
11ZNF263_19887448_ChIP-Seq_K562_Human2.81745080
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.75695959
13* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.70356405
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.65869840
15MYC_22102868_ChIP-Seq_BL_Human2.63746740
16* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.57493830
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36032352
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24995691
19* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20180297
20ESR1_15608294_ChIP-ChIP_MCF-7_Human2.06769386
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05980055
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.01148053
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98825154
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.93429119
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.91153276
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88410718
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.87757613
28* TCF7_22412390_ChIP-Seq_EML_Mouse1.83742999
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.80680748
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74846363
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67998104
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65555211
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62957348
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59059659
35* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56601607
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55503483
37E2F7_22180533_ChIP-Seq_HELA_Human1.53901769
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.53650511
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52751819
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.52566950
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.49760405
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49480084
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49143325
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48449823
45* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46397167
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45809975
47* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44002797
48* LXR_22292898_ChIP-Seq_THP-1_Human1.43805523
49TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42801682
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42687373
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40664752
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39426709
53* CDX2_20551321_ChIP-Seq_CACO-2_Human1.36901541
54* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36729520
55CLOCK_20551151_ChIP-Seq_293T_Human1.36492018
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36010530
57* SMC4_20622854_ChIP-Seq_HELA_Human1.35686869
58* VDR_21846776_ChIP-Seq_THP-1_Human1.35025987
59* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34078769
60KDM2B_26808549_Chip-Seq_DND41_Human1.32752656
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31935440
62* CREB1_26743006_Chip-Seq_LNCaP_Human1.30773755
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29451135
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.29283963
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.28842907
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.27436174
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26190643
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25816867
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24862513
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.24050432
71NCOR1_26117541_ChIP-Seq_K562_Human1.23820659
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.23705741
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22780434
74RACK7_27058665_Chip-Seq_MCF-7_Human1.22766712
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21996359
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21225994
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20857078
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19960035
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.19331132
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19014464
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18274101
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18001704
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17297758
84* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16552505
85* ESR2_21235772_ChIP-Seq_MCF-7_Human1.14985611
86SCL_19346495_ChIP-Seq_HPC-7_Human1.14670670
87* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11834222
88* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11294433
89* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11142879
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10746263
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10478121
92MAF_26560356_Chip-Seq_TH1_Human1.10406057
93P68_20966046_ChIP-Seq_HELA_Human1.10234838
94GATA6_25053715_ChIP-Seq_YYC3_Human1.10007548
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09155921
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08031273
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07613086
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07324618
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07048307
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06785711
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05992704
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05651234
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05562327
104UTX_26944678_Chip-Seq_JUKART_Human1.05223255
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.04184809
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03217881
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02157453
108* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01509548
109CTCF_27219007_Chip-Seq_Bcells_Human1.01253272
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01203917
111* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01110043
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00904192
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00292352
114MYB_26560356_Chip-Seq_TH1_Human1.00291524
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99898103
116OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99853278
117* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99808296
118* TP53_22127205_ChIP-Seq_IMR90_Human0.99721316
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99362940
120* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99316823
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98494610
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98466214
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96638956
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96638956
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95630025
126* KDM2B_26808549_Chip-Seq_K562_Human0.95329469
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94581350
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93998056
129* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93419076
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91387469
131RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90055235
132OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89644335
133EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89332038
134IRF8_21731497_ChIP-ChIP_J774_Mouse0.88095876
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85786771
136NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85677462
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84315893
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.84215847
139* BCOR_27268052_Chip-Seq_Bcells_Human0.83512482
140POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83371504
141* CTCF_21964334_Chip-Seq_Bcells_Human0.83171803
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82104136
143* ATF3_27146783_Chip-Seq_COLON_Human0.81895347
144RUNX1_22412390_ChIP-Seq_EML_Mouse0.81087242
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80699489
146ESR1_21235772_ChIP-Seq_MCF-7_Human0.80502476
147* RUNX1_27514584_Chip-Seq_MCF-7_Human0.80356390
148HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80175997
149NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79895355
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79339528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.46154517
2MP0005360_urolithiasis5.37266669
3MP0005365_abnormal_bile_salt4.05321270
4MP0005085_abnormal_gallbladder_physiolo4.03816540
5MP0002254_reproductive_system_inflammat3.65667055
6MP0003705_abnormal_hypodermis_morpholog3.49203997
7MP0008875_abnormal_xenobiotic_pharmacok3.26993251
8MP0003252_abnormal_bile_duct3.19584546
9MP0000566_synostosis2.90856696
10MP0009840_abnormal_foam_cell2.89854333
11MP0005409_darkened_coat_color2.77906552
12MP0010329_abnormal_lipoprotein_level2.59054224
13MP0004264_abnormal_extraembryonic_tissu2.49247205
14MP0000579_abnormal_nail_morphology2.48589386
15MP0003011_delayed_dark_adaptation2.48287725
16MP0003191_abnormal_cellular_cholesterol2.45233991
17MP0002089_abnormal_postnatal_growth/wei2.41305589
18MP0001348_abnormal_lacrimal_gland2.32501015
19MP0000537_abnormal_urethra_morphology2.27552776
20MP0005083_abnormal_biliary_tract2.16768535
21MP0000609_abnormal_liver_physiology2.11654135
22MP0003453_abnormal_keratinocyte_physiol2.10637639
23MP0004272_abnormal_basement_membrane2.07510750
24MP0003941_abnormal_skin_development2.05674294
25MP0003806_abnormal_nucleotide_metabolis2.04504388
26MP0010352_gastrointestinal_tract_polyps1.89546306
27MP0005058_abnormal_lysosome_morphology1.83145979
28MP0003123_paternal_imprinting1.78092866
29MP0002877_abnormal_melanocyte_morpholog1.75835545
30MP0002138_abnormal_hepatobiliary_system1.75018854
31MP0003890_abnormal_embryonic-extraembry1.73429635
32MP0000678_abnormal_parathyroid_gland1.65231655
33MP0005332_abnormal_amino_acid1.63773978
34MP0002796_impaired_skin_barrier1.62596742
35MP0001666_abnormal_nutrient_absorption1.62090637
36* MP0003091_abnormal_cell_migration1.59693079
37MP0008961_abnormal_basal_metabolism1.57529743
38* MP0005319_abnormal_enzyme/_coenzyme1.54844497
39MP0002098_abnormal_vibrissa_morphology1.50797393
40MP0000762_abnormal_tongue_morphology1.47679269
41MP0005623_abnormal_meninges_morphology1.46935490
42MP0004858_abnormal_nervous_system1.46582840
43MP0008260_abnormal_autophagy1.46458073
44MP0006082_CNS_inflammation1.44041157
45MP0008438_abnormal_cutaneous_collagen1.41033783
46MP0005501_abnormal_skin_physiology1.40612484
47MP0000467_abnormal_esophagus_morphology1.39388078
48MP0001835_abnormal_antigen_presentation1.37229796
49MP0003115_abnormal_respiratory_system1.35786942
50MP0002249_abnormal_larynx_morphology1.35531810
51MP0009780_abnormal_chondrocyte_physiolo1.34753073
52MP0003122_maternal_imprinting1.34168055
53MP0002118_abnormal_lipid_homeostasis1.33575454
54MP0003329_amyloid_beta_deposits1.31675522
55MP0004019_abnormal_vitamin_homeostasis1.30838467
56MP0003942_abnormal_urinary_system1.30505309
57MP0002822_catalepsy1.28857920
58MP0000598_abnormal_liver_morphology1.28282460
59MP0003300_gastrointestinal_ulcer1.27374577
60MP0002060_abnormal_skin_morphology1.24074700
61MP0005670_abnormal_white_adipose1.21545527
62MP0000003_abnormal_adipose_tissue1.20952466
63MP0000534_abnormal_ureter_morphology1.19904184
64MP0001216_abnormal_epidermal_layer1.19828321
65* MP0001800_abnormal_humoral_immune1.18794750
66MP0004233_abnormal_muscle_weight1.17006433
67MP0003436_decreased_susceptibility_to1.16987237
68MP0002896_abnormal_bone_mineralization1.15419296
69* MP0002697_abnormal_eye_size1.15210729
70MP0002332_abnormal_exercise_endurance1.14643112
71MP0005387_immune_system_phenotype1.12609334
72MP0001790_abnormal_immune_system1.12609334
73MP0003303_peritoneal_inflammation1.08868271
74MP0000685_abnormal_immune_system1.07334983
75MP0001849_ear_inflammation1.05860738
76MP0005076_abnormal_cell_differentiation1.05365491
77MP0002088_abnormal_embryonic_growth/wei1.05043179
78MP0010030_abnormal_orbit_morphology1.04605880
79MP0003315_abnormal_perineum_morphology1.02765492
80MP0005075_abnormal_melanosome_morpholog1.01711040
81MP0000462_abnormal_digestive_system1.01491731
82MP0003984_embryonic_growth_retardation1.00867403
83MP0003868_abnormal_feces_composition1.00126420
84MP0005380_embryogenesis_phenotype0.99110282
85MP0001672_abnormal_embryogenesis/_devel0.99110282
86MP0000858_altered_metastatic_potential0.98900640
87MP0003566_abnormal_cell_adhesion0.96688632
88MP0003385_abnormal_body_wall0.95272621
89MP0005647_abnormal_sex_gland0.94831983
90MP0000377_abnormal_hair_follicle0.94232473
91MP0000733_abnormal_muscle_development0.94016983
92MP0005375_adipose_tissue_phenotype0.93944608
93MP0006035_abnormal_mitochondrial_morpho0.93272195
94MP0005023_abnormal_wound_healing0.93169048
95MP0002970_abnormal_white_adipose0.93009183
96* MP0009643_abnormal_urine_homeostasis0.92513868
97MP0009115_abnormal_fat_cell0.90793978
98MP0010678_abnormal_skin_adnexa0.89661555
99* MP0005584_abnormal_enzyme/coenzyme_acti0.86206369
100MP0002086_abnormal_extraembryonic_tissu0.85372412
101MP0009384_cardiac_valve_regurgitation0.85127209
102MP0005666_abnormal_adipose_tissue0.84764738
103MP0010368_abnormal_lymphatic_system0.83169753
104MP0009763_increased_sensitivity_to0.82401218
105* MP0008469_abnormal_protein_level0.80702328
106MP0004185_abnormal_adipocyte_glucose0.80318205
107MP0000477_abnormal_intestine_morphology0.79006231
108MP0003172_abnormal_lysosome_physiology0.78929695
109MP0002928_abnormal_bile_duct0.78724615
110MP0005266_abnormal_metabolism0.78326491
111MP0002116_abnormal_craniofacial_bone0.78323072
112* MP0002452_abnormal_antigen_presenting0.77909163
113MP0002396_abnormal_hematopoietic_system0.77219415
114MP0000432_abnormal_head_morphology0.76814703
115* MP0000689_abnormal_spleen_morphology0.76313754
116MP0002085_abnormal_embryonic_tissue0.76152902
117MP0010234_abnormal_vibrissa_follicle0.75918299
118MP0009764_decreased_sensitivity_to0.75369630
119* MP0002136_abnormal_kidney_physiology0.74615127
120MP0003634_abnormal_glial_cell0.73115520
121* MP0002092_abnormal_eye_morphology0.73070020
122MP0000604_amyloidosis0.72495401
123* MP0003861_abnormal_nervous_system0.72341022
124MP0000428_abnormal_craniofacial_morphol0.72320890
125MP0001299_abnormal_eye_distance/0.71448065
126MP0003935_abnormal_craniofacial_develop0.71383479
127MP0009931_abnormal_skin_appearance0.71142423
128MP0004197_abnormal_fetal_growth/weight/0.69497756
129MP0003755_abnormal_palate_morphology0.69444365
130* MP0005621_abnormal_cell_physiology0.69376879
131MP0005248_abnormal_Harderian_gland0.69050605
132MP0004270_analgesia0.68759989
133MP0000627_abnormal_mammary_gland0.68479091
134MP0002111_abnormal_tail_morphology0.68376332
135MP0000569_abnormal_digit_pigmentation0.66185617
136MP0004947_skin_inflammation0.65743588
137MP0001845_abnormal_inflammatory_respons0.65381223
138MP0009053_abnormal_anal_canal0.64861625
139MP0009765_abnormal_xenobiotic_induced0.64325886
140MP0000350_abnormal_cell_proliferation0.62367856
141MP0002722_abnormal_immune_system0.62302870
142MP0005394_taste/olfaction_phenotype0.61562871
143MP0005499_abnormal_olfactory_system0.61562871
144MP0009672_abnormal_birth_weight0.60594717
145MP0005464_abnormal_platelet_physiology0.59442258
146* MP0002723_abnormal_immune_serum0.58306470
147* MP0000716_abnormal_immune_system0.57811656
148MP0005000_abnormal_immune_tolerance0.57756780
149MP0003656_abnormal_erythrocyte_physiolo0.57115369
150MP0004782_abnormal_surfactant_physiolog0.56810590
151* MP0009642_abnormal_blood_homeostasis0.56757904
152MP0005451_abnormal_body_composition0.56225917
153MP0002653_abnormal_ependyma_morphology0.55919876
154MP0001730_embryonic_growth_arrest0.55896555
155MP0001915_intracranial_hemorrhage0.55469715
156* MP0002429_abnormal_blood_cell0.55362581
157MP0004883_abnormal_blood_vessel0.55175889
158MP0008057_abnormal_DNA_replication0.54980291
159MP0005334_abnormal_fat_pad0.54592692
160MP0005376_homeostasis/metabolism_phenot0.53932330
161MP0004957_abnormal_blastocyst_morpholog0.53459440
162MP0009278_abnormal_bone_marrow0.53328676

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.21868352
2Deep venous thrombosis (HP:0002625)4.92206533
3Complement deficiency (HP:0004431)4.30956728
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.28956484
5Intrahepatic cholestasis (HP:0001406)4.19743644
6Xanthomatosis (HP:0000991)4.15721253
7Abnormality of the lower motor neuron (HP:0002366)4.03162532
8Hyperacusis (HP:0010780)3.87664231
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.84654717
10Hepatoblastoma (HP:0002884)3.76605184
11Hypobetalipoproteinemia (HP:0003563)3.67974158
12Multiple enchondromatosis (HP:0005701)3.58620185
13Bilateral microphthalmos (HP:0007633)3.47429159
14Abnormality of complement system (HP:0005339)3.46504971
15Atrophic scars (HP:0001075)3.36670468
16Asymmetry of the thorax (HP:0001555)3.33878051
17Abnormality of the intrinsic pathway (HP:0010989)3.23546124
18Flat acetabular roof (HP:0003180)3.20469276
19Upper motor neuron abnormality (HP:0002127)3.18499813
20Joint hemorrhage (HP:0005261)3.06928846
21Abnormal cartilage morphology (HP:0002763)3.06097576
22Prolonged partial thromboplastin time (HP:0003645)3.05103000
23Myocardial infarction (HP:0001658)3.04506801
24Hypolipoproteinemia (HP:0010981)3.01494559
25Malnutrition (HP:0004395)2.99640195
26Systemic lupus erythematosus (HP:0002725)2.98604208
27Epidermoid cyst (HP:0200040)2.94142515
28Hypoalphalipoproteinemia (HP:0003233)2.91520049
29Protrusio acetabuli (HP:0003179)2.89572201
30Abnormality of sulfur amino acid metabolism (HP:0004339)2.87557717
31Skin nodule (HP:0200036)2.86725156
32Hyperammonemia (HP:0001987)2.82395576
33Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81718973
34Hyperglycinuria (HP:0003108)2.80066394
35Hypercholesterolemia (HP:0003124)2.80001744
36Broad face (HP:0000283)2.79573312
37Hyperlipoproteinemia (HP:0010980)2.74670130
38Colitis (HP:0002583)2.68894209
39Pseudobulbar signs (HP:0002200)2.67168201
40Hypochromic anemia (HP:0001931)2.66891933
41Thin bony cortex (HP:0002753)2.62805419
42Hand muscle atrophy (HP:0009130)2.62051633
43Premature rupture of membranes (HP:0001788)2.62034493
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.59201369
45Glomerulonephritis (HP:0000099)2.58791816
46Abnormality of the Achilles tendon (HP:0005109)2.54640881
47Bronchomalacia (HP:0002780)2.51674405
48Abnormality of the common coagulation pathway (HP:0010990)2.48914355
49Abnormality of pyrimidine metabolism (HP:0004353)2.45104065
50Abnormality of serine family amino acid metabolism (HP:0010894)2.42180128
51Abnormality of glycine metabolism (HP:0010895)2.42180128
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40383729
53Advanced eruption of teeth (HP:0006288)2.40292944
54Ketosis (HP:0001946)2.37669001
55Natal tooth (HP:0000695)2.37410903
56Milia (HP:0001056)2.36930433
57Insomnia (HP:0100785)2.33623571
58Renovascular hypertension (HP:0100817)2.33590620
59Renal duplication (HP:0000075)2.30704976
60Back pain (HP:0003418)2.29555356
61Hyperinsulinemic hypoglycemia (HP:0000825)2.29111016
62Fragile skin (HP:0001030)2.28423456
63Shallow orbits (HP:0000586)2.23511678
64Gout (HP:0001997)2.23373413
65Neonatal short-limb short stature (HP:0008921)2.21557297
66Ragged-red muscle fibers (HP:0003200)2.19989572
67Ependymoma (HP:0002888)2.19623473
68Nasal polyposis (HP:0100582)2.14941817
69Abnormality of carpal bone ossification (HP:0006257)2.14877544
70Long palpebral fissure (HP:0000637)2.14866643
71Achilles tendon contracture (HP:0001771)2.14430859
72Elfin facies (HP:0004428)2.13708736
73Abnormality of nucleobase metabolism (HP:0010932)2.13541215
74Spastic diplegia (HP:0001264)2.13227724
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13058635
76Upper limb amyotrophy (HP:0009129)2.10252168
77Distal upper limb amyotrophy (HP:0007149)2.10252168
78Hepatocellular carcinoma (HP:0001402)2.10072920
79Hyperglycinemia (HP:0002154)2.08063385
80Ulnar bowing (HP:0003031)2.06729511
81Overriding aorta (HP:0002623)2.06471227
82Abnormal ossification of hand bones (HP:0005921)2.04304161
83Neoplasm of striated muscle (HP:0009728)2.04041223
84Abnormality of the distal phalanx of the thumb (HP:0009617)2.02820591
85Esophageal varix (HP:0002040)2.00945315
86Mitral stenosis (HP:0001718)2.00404864
87Abnormality of the gastric mucosa (HP:0004295)1.98661619
88Abnormality of purine metabolism (HP:0004352)1.97759790
89Abnormality of methionine metabolism (HP:0010901)1.96760059
90Amyotrophic lateral sclerosis (HP:0007354)1.95853841
91Vertebral arch anomaly (HP:0008438)1.95528332
92Lymphangioma (HP:0100764)1.94806559
93Pterygium (HP:0001059)1.94628274
94Focal segmental glomerulosclerosis (HP:0000097)1.94204459
95Recurrent gram-negative bacterial infections (HP:0005420)1.94022054
96Mitral valve prolapse (HP:0001634)1.92980553
97Bladder diverticulum (HP:0000015)1.92267852
98Fat malabsorption (HP:0002630)1.92145016
99Arnold-Chiari malformation (HP:0002308)1.91930975
100Cervical subluxation (HP:0003308)1.91858891
101Cerebral inclusion bodies (HP:0100314)1.90216982
102Hyperparathyroidism (HP:0000843)1.89212977
103Tetraplegia (HP:0002445)1.89115787
104Testicular atrophy (HP:0000029)1.86898247
105Abnormality of the nasal mucosa (HP:0000433)1.86140659
106Cerebral aneurysm (HP:0004944)1.85477614
107Rib fusion (HP:0000902)1.84659025
108Hemorrhage of the eye (HP:0011885)1.84096633
109Fragile nails (HP:0001808)1.83975236
110Neurofibrillary tangles (HP:0002185)1.82929989
111Nephritis (HP:0000123)1.82733705
112Amyloidosis (HP:0011034)1.82019277
113Peritonitis (HP:0002586)1.81877771
114Progressive sensorineural hearing impairment (HP:0000408)1.81291104
115Turricephaly (HP:0000262)1.80899603
116Abdominal distention (HP:0003270)1.80502281
117Large earlobe (HP:0009748)1.79806834
118Rhabdomyosarcoma (HP:0002859)1.76823613
119Biconcave vertebral bodies (HP:0004586)1.76485394
120Agammaglobulinemia (HP:0004432)1.76381957
121Increased CSF protein (HP:0002922)1.75945576
122Ankyloglossia (HP:0010296)1.75509973
123Gingival bleeding (HP:0000225)1.74945149
124Disproportionate tall stature (HP:0001519)1.73531398
125Right ventricular cardiomyopathy (HP:0011663)1.73274580
126Tibial bowing (HP:0002982)1.72883155
127Germ cell neoplasia (HP:0100728)1.72319384
128Inflammation of the large intestine (HP:0002037)1.72085152
129Abnormality of iron homeostasis (HP:0011031)1.71985492
130Abnormality of transition element cation homeostasis (HP:0011030)1.71696814
131Short nail (HP:0001799)1.71601110
132Cellulitis (HP:0100658)1.70391123
133Cupped ribs (HP:0000887)1.70193454
134Mitral regurgitation (HP:0001653)1.69875626
135Increased connective tissue (HP:0009025)1.69805697
136Gastrointestinal inflammation (HP:0004386)1.69238269
137Abnormality of glycolipid metabolism (HP:0010969)1.67277134
138Abnormality of liposaccharide metabolism (HP:0010968)1.67277134
139Abnormality of glycosphingolipid metabolism (HP:0004343)1.67277134
140Arterial tortuosity (HP:0005116)1.66407491
141Camptodactyly of toe (HP:0001836)1.66390153
142Arthropathy (HP:0003040)1.65732172
143Abnormality of the astrocytes (HP:0100707)1.65717778
144Astrocytoma (HP:0009592)1.65717778
145Abnormality of small intestinal villus morphology (HP:0011472)1.64388214
146Villous atrophy (HP:0011473)1.64388214
147Heterotopia (HP:0002282)1.63389913
148Abnormal tarsal ossification (HP:0008369)1.62806890
149Skin tags (HP:0010609)1.62791204
150Obstructive sleep apnea (HP:0002870)1.61999893
151Abnormality of the motor neurons (HP:0002450)1.61891885
152Vertebral compression fractures (HP:0002953)1.61705138
153Termporal pattern (HP:0011008)1.61678400
154Insidious onset (HP:0003587)1.61678400
155Hypoplasia of dental enamel (HP:0006297)1.61549647
156Aplasia involving bones of the extremities (HP:0009825)1.61468766
157Aplasia involving bones of the upper limbs (HP:0009823)1.61468766
158Aplasia of the phalanges of the hand (HP:0009802)1.61468766
159Patellar dislocation (HP:0002999)1.61410702
160Flattened epiphyses (HP:0003071)1.61244507
161Morphological abnormality of the middle ear (HP:0008609)1.58449117
162Abnormality of the thoracic spine (HP:0100711)1.58438892
163Blue sclerae (HP:0000592)1.58323218
164Spina bifida occulta (HP:0003298)1.57814609
165Small epiphyses (HP:0010585)1.57761246
166Deviation of the thumb (HP:0009603)1.57277202
167Polygenic inheritance (HP:0010982)1.57041214
168Neonatal death (HP:0003811)1.56260123
169J-shaped sella turcica (HP:0002680)1.55286065
170Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54911575
171Limited elbow extension (HP:0001377)1.53448123
172Leiomyosarcoma (HP:0100243)1.53396774
173Uterine leiomyosarcoma (HP:0002891)1.53396774
174Precocious puberty (HP:0000826)1.53004890
175Abnormal vertebral ossification (HP:0100569)1.52577639
176Abnormal hand bone ossification (HP:0010660)1.52376408
177Selective tooth agenesis (HP:0001592)1.52144167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.80730021
2ERN15.58055844
3GRK63.61045587
4MAP3K103.49649869
5SMG13.21493704
6TGFBR23.16907317
7TRIB32.44509381
8SIK12.42934972
9STK102.40114403
10MST1R2.34935125
11PRPF4B2.32716870
12IRAK32.31970225
13GRK52.28896819
14MAP4K11.84605734
15PKN21.83696481
16EEF2K1.79732386
17MATK1.76768266
18FGFR41.59339340
19* CSF1R1.53029270
20GRK11.47559526
21TYRO31.45493061
22MET1.41854949
23TYK21.41780281
24DDR21.40965735
25MAPK71.38639902
26SIK21.35347211
27ICK1.32591562
28FGFR31.29774932
29EPHB21.27239072
30PTK61.26968521
31CAMK1D1.26055172
32NME21.23977593
33CDC42BPA1.19835171
34EPHA21.18363313
35BCKDK1.16613416
36LRRK21.12344378
37CSK1.11888419
38PAK41.11759770
39TTK1.08884416
40MTOR1.08704589
41RPS6KA21.07893909
42RIPK11.06722838
43LMTK21.06211209
44LATS11.05524253
45GRK71.04140515
46MAP3K71.02992313
47ADRBK20.99724259
48BLK0.96287168
49PDGFRA0.89720625
50TAOK30.89523971
51TAOK10.88679362
52TESK10.87380604
53CAMK1G0.87290089
54ARAF0.87251967
55JAK10.86339596
56WNK10.85927222
57PIM20.85740294
58MAP2K40.85265640
59CDK40.83307568
60CAMK40.80506186
61NEK20.78751621
62MAPK120.77218790
63MOS0.76668018
64TTN0.74701664
65RET0.74267144
66MAP2K30.73528663
67ALK0.73490276
68SIK30.72370393
69PDPK10.71991212
70JAK20.71666783
71NTRK10.71518851
72KSR20.71453995
73MARK20.71317031
74BRD40.69538372
75PRKD20.69317115
76CDK60.67397436
77PRKG20.66650460
78STK30.65566057
79FLT30.64886562
80RPS6KL10.64877409
81RPS6KC10.64877409
82MAP2K20.64105413
83TAOK20.62438208
84CHUK0.61200980
85DYRK1B0.60943089
86TBK10.60348777
87PTK20.59577063
88MAP3K30.59000997
89MAPKAPK30.58023517
90FRK0.57792414
91JAK30.56753945
92LATS20.56269940
93ITK0.56134744
94ERBB20.52942958
95AKT30.52670986
96PAK20.51735525
97CDK70.51566691
98HCK0.50966883
99IRAK20.50476522
100NEK90.49922030
101IKBKB0.48575849
102SCYL20.48488841
103BMX0.48303447
104FGR0.48017899
105ZAP700.47899417
106AKT20.47587151
107MAP3K60.47575825
108SYK0.47240262
109SGK30.47121996
110HIPK20.46637954
111RPS6KB20.46336854
112GSK3A0.46192152
113PRKD30.45434094
114BCR0.45021484
115PRKAA10.44284958
116MAP3K130.43636851
117MAP3K10.43196315
118MAPK110.42221768
119RPS6KA60.41210040
120PRKCI0.41151739
121RPS6KA10.40536251
122FGFR10.39382996
123MAPK40.38604561
124MAP3K140.37823853
125ROCK20.37802032
126CDK90.37544301
127PRKCZ0.36729391
128PRKAA20.36016385
129RPS6KA40.35279529
130CDK11A0.35021446
131KSR10.34607872
132MAP3K90.34418076
133BTK0.33817207
134CDK150.33711801
135PDK10.33548150
136KIT0.33046406
137MAP3K80.32914834
138PDGFRB0.32223925
139CAMKK10.32172983
140MELK0.30806538
141CDK180.30750559
142CHEK10.30403627
143EPHB10.30137988
144ERBB40.30036934
145MARK10.29375170
146ADRBK10.28917874
147CHEK20.28497782
148BRAF0.28268508
149MAPK100.27921741
150* INSR0.27637821
151* IGF1R0.26564284

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.57083618
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53454151
3Nitrogen metabolism_Homo sapiens_hsa009103.13338979
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93781301
5Complement and coagulation cascades_Homo sapiens_hsa046102.79649496
6Arginine biosynthesis_Homo sapiens_hsa002202.78010903
7Tryptophan metabolism_Homo sapiens_hsa003802.55604089
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38594643
9Vitamin B6 metabolism_Homo sapiens_hsa007502.07630930
10Staphylococcus aureus infection_Homo sapiens_hsa051502.07305977
11Fatty acid degradation_Homo sapiens_hsa000712.00233319
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00183516
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99791061
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93684431
15PPAR signaling pathway_Homo sapiens_hsa033201.88896484
16Notch signaling pathway_Homo sapiens_hsa043301.87976144
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81315837
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80056253
19Selenocompound metabolism_Homo sapiens_hsa004501.70555780
20Chemical carcinogenesis_Homo sapiens_hsa052041.66310627
21Caffeine metabolism_Homo sapiens_hsa002321.60909280
22Endometrial cancer_Homo sapiens_hsa052131.54458051
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52105092
24Bile secretion_Homo sapiens_hsa049761.46727545
25Lysine degradation_Homo sapiens_hsa003101.43162938
26Thyroid cancer_Homo sapiens_hsa052161.40872452
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38425881
28Fatty acid metabolism_Homo sapiens_hsa012121.37107024
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34803627
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32958640
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32812962
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32758646
33Fat digestion and absorption_Homo sapiens_hsa049751.32280407
34ECM-receptor interaction_Homo sapiens_hsa045121.32079110
35Fructose and mannose metabolism_Homo sapiens_hsa000511.30851627
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.29119103
37ErbB signaling pathway_Homo sapiens_hsa040121.27438058
38Peroxisome_Homo sapiens_hsa041461.27378996
39Butanoate metabolism_Homo sapiens_hsa006501.26149602
40ABC transporters_Homo sapiens_hsa020101.25960765
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24845254
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.20954889
43VEGF signaling pathway_Homo sapiens_hsa043701.20256885
44Histidine metabolism_Homo sapiens_hsa003401.19140891
45Retinol metabolism_Homo sapiens_hsa008301.19103778
46beta-Alanine metabolism_Homo sapiens_hsa004101.18384667
47Renal cell carcinoma_Homo sapiens_hsa052111.18148678
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15283630
49Propanoate metabolism_Homo sapiens_hsa006401.15185351
50* Focal adhesion_Homo sapiens_hsa045101.13524945
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13350955
52* Proteoglycans in cancer_Homo sapiens_hsa052051.13165714
53Sulfur relay system_Homo sapiens_hsa041221.12369042
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.11864802
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08304564
56Axon guidance_Homo sapiens_hsa043601.07026911
57Phenylalanine metabolism_Homo sapiens_hsa003601.06999689
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06064766
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05641360
60Biosynthesis of amino acids_Homo sapiens_hsa012301.05184255
61Amoebiasis_Homo sapiens_hsa051461.04728724
62Starch and sucrose metabolism_Homo sapiens_hsa005001.04464151
63Carbon metabolism_Homo sapiens_hsa012001.02843232
64One carbon pool by folate_Homo sapiens_hsa006700.99958507
65Folate biosynthesis_Homo sapiens_hsa007900.98142143
66Prostate cancer_Homo sapiens_hsa052150.97691739
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.94880919
68Hippo signaling pathway_Homo sapiens_hsa043900.94540022
69* B cell receptor signaling pathway_Homo sapiens_hsa046620.93708318
70Prolactin signaling pathway_Homo sapiens_hsa049170.91635765
71Galactose metabolism_Homo sapiens_hsa000520.90086299
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88109297
73Tight junction_Homo sapiens_hsa045300.88077824
74Pentose phosphate pathway_Homo sapiens_hsa000300.85800289
75Estrogen signaling pathway_Homo sapiens_hsa049150.85769224
76Tyrosine metabolism_Homo sapiens_hsa003500.84380252
77Glioma_Homo sapiens_hsa052140.84322306
78Pyruvate metabolism_Homo sapiens_hsa006200.82499697
79Glycerolipid metabolism_Homo sapiens_hsa005610.80582111
80Insulin resistance_Homo sapiens_hsa049310.79973223
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.77428691
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.77130445
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76557920
84mTOR signaling pathway_Homo sapiens_hsa041500.75617169
85Basal cell carcinoma_Homo sapiens_hsa052170.75249870
86Colorectal cancer_Homo sapiens_hsa052100.74139163
87Choline metabolism in cancer_Homo sapiens_hsa052310.72686876
88Protein digestion and absorption_Homo sapiens_hsa049740.72245033
89Thyroid hormone synthesis_Homo sapiens_hsa049180.71687173
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69185036
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68379721
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67319226
93GnRH signaling pathway_Homo sapiens_hsa049120.67094594
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.66739000
95Type II diabetes mellitus_Homo sapiens_hsa049300.65351433
96Hepatitis B_Homo sapiens_hsa051610.61316123
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.61283962
98Glucagon signaling pathway_Homo sapiens_hsa049220.60750822
99Influenza A_Homo sapiens_hsa051640.60129202
100Vitamin digestion and absorption_Homo sapiens_hsa049770.58355654
101HIF-1 signaling pathway_Homo sapiens_hsa040660.56714487
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56583662
103TNF signaling pathway_Homo sapiens_hsa046680.55706063
104Pathways in cancer_Homo sapiens_hsa052000.55499591
105Acute myeloid leukemia_Homo sapiens_hsa052210.55222326
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54189231
107Vibrio cholerae infection_Homo sapiens_hsa051100.54095628
108Fatty acid biosynthesis_Homo sapiens_hsa000610.54016905
109Salmonella infection_Homo sapiens_hsa051320.53449303
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51089551
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51052049
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50942999
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.50745653
114N-Glycan biosynthesis_Homo sapiens_hsa005100.50426698
115AMPK signaling pathway_Homo sapiens_hsa041520.50357761
116Sphingolipid metabolism_Homo sapiens_hsa006000.49534108
117Shigellosis_Homo sapiens_hsa051310.48168992
118Other glycan degradation_Homo sapiens_hsa005110.44669015
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.44100448
120Primary immunodeficiency_Homo sapiens_hsa053400.43653797
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41335818
122Non-small cell lung cancer_Homo sapiens_hsa052230.40583954
123Chronic myeloid leukemia_Homo sapiens_hsa052200.37778690
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37627831
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.36926956
126Osteoclast differentiation_Homo sapiens_hsa043800.35855780
127Prion diseases_Homo sapiens_hsa050200.35787690
128Arginine and proline metabolism_Homo sapiens_hsa003300.35555493
129Pancreatic cancer_Homo sapiens_hsa052120.35471655
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35468180
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34954085
132* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33081729
133Renin-angiotensin system_Homo sapiens_hsa046140.31653435
134Linoleic acid metabolism_Homo sapiens_hsa005910.29406673
135Apoptosis_Homo sapiens_hsa042100.29314749
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27041531
137Antigen processing and presentation_Homo sapiens_hsa046120.26684112
138Small cell lung cancer_Homo sapiens_hsa052220.26592719
139Toxoplasmosis_Homo sapiens_hsa051450.26492294
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26187399
141Steroid biosynthesis_Homo sapiens_hsa001000.24904358
142Adherens junction_Homo sapiens_hsa045200.23982700
143Bladder cancer_Homo sapiens_hsa052190.23805508
144Leishmaniasis_Homo sapiens_hsa051400.23269596
145* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22683230
146MicroRNAs in cancer_Homo sapiens_hsa052060.21133566
147Sulfur metabolism_Homo sapiens_hsa009200.20963793
148Glutathione metabolism_Homo sapiens_hsa004800.20836651
149Insulin signaling pathway_Homo sapiens_hsa049100.20595007
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18451070
151Hepatitis C_Homo sapiens_hsa051600.18415268

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