VASN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.78198594
2protein heterotrimerization (GO:0070208)6.57733818
3skin morphogenesis (GO:0043589)5.49612353
4chondrocyte proliferation (GO:0035988)5.49544616
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.88963087
6endodermal cell differentiation (GO:0035987)4.87811678
7sequestering of extracellular ligand from receptor (GO:0035581)4.71726509
8bone trabecula formation (GO:0060346)4.71295612
9type B pancreatic cell proliferation (GO:0044342)4.70192401
10cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.54826304
11collagen metabolic process (GO:0032963)4.49620759
12collagen catabolic process (GO:0030574)4.43017683
13wound healing, spreading of epidermal cells (GO:0035313)4.40766758
14positive regulation of endothelial cell apoptotic process (GO:2000353)4.38474709
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.35965548
16adhesion of symbiont to host cell (GO:0044650)4.27380751
17virion attachment to host cell (GO:0019062)4.27380751
18multicellular organismal macromolecule metabolic process (GO:0044259)4.24219525
19cell adhesion mediated by integrin (GO:0033627)4.19713979
20axon extension involved in axon guidance (GO:0048846)4.19659216
21neuron projection extension involved in neuron projection guidance (GO:1902284)4.19659216
22multicellular organismal catabolic process (GO:0044243)4.11282448
23apoptotic cell clearance (GO:0043277)4.03604393
24multicellular organismal metabolic process (GO:0044236)4.01370107
25glomerular basement membrane development (GO:0032836)3.99429508
26negative regulation of fatty acid transport (GO:2000192)3.96103611
27keratan sulfate catabolic process (GO:0042340)3.93648534
28adhesion of symbiont to host (GO:0044406)3.83612360
29extracellular matrix disassembly (GO:0022617)3.83014132
30endothelial cell morphogenesis (GO:0001886)3.78705988
31peptidyl-proline hydroxylation (GO:0019511)3.77588957
32chondrocyte development (GO:0002063)3.76628360
33mesenchymal-epithelial cell signaling (GO:0060638)3.67879419
34wound healing, spreading of cells (GO:0044319)3.57521859
35positive regulation of extracellular matrix organization (GO:1903055)3.51209575
36basement membrane organization (GO:0071711)3.48546741
37vascular endothelial growth factor signaling pathway (GO:0038084)3.38825481
38cellular response to vitamin (GO:0071295)3.38616580
39protein hydroxylation (GO:0018126)3.36430264
40metanephric mesenchyme development (GO:0072075)3.32783802
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31319026
42positive regulation of epithelial to mesenchymal transition (GO:0010718)3.30012018
43extracellular matrix assembly (GO:0085029)3.29717779
44dermatan sulfate biosynthetic process (GO:0030208)3.28709526
45extracellular fibril organization (GO:0043206)3.24031395
46regulation of tight junction assembly (GO:2000810)3.23626687
47tooth mineralization (GO:0034505)3.23080845
48negative regulation of chondrocyte differentiation (GO:0032331)3.22643267
49protein retention in ER lumen (GO:0006621)3.16911243
50epithelial cell-cell adhesion (GO:0090136)3.15656108
51extracellular matrix organization (GO:0030198)3.15587807
52retina vasculature morphogenesis in camera-type eye (GO:0061299)3.14755633
53extracellular structure organization (GO:0043062)3.14509368
54positive regulation of blood vessel endothelial cell migration (GO:0043536)3.11681835
55kidney mesenchyme development (GO:0072074)3.11537604
56venous blood vessel morphogenesis (GO:0048845)3.10885037
57heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.10752061
58adherens junction assembly (GO:0034333)3.10263108
59fibril organization (GO:0097435)3.09910358
60glomerular visceral epithelial cell development (GO:0072015)3.06941300
61barbed-end actin filament capping (GO:0051016)3.05724433
62protein localization to cell surface (GO:0034394)3.05565839
63glomerular epithelial cell development (GO:0072310)3.05277053
64focal adhesion assembly (GO:0048041)3.05009233
65cell-substrate adherens junction assembly (GO:0007045)3.05009233
66negative regulation of smooth muscle cell migration (GO:0014912)3.03735819
67cellular response to vitamin D (GO:0071305)3.03076665
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.01949399
69craniofacial suture morphogenesis (GO:0097094)3.01746689
70positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.01577001
71dermatan sulfate metabolic process (GO:0030205)2.99190710
72cochlea morphogenesis (GO:0090103)2.96788589
73hyaluronan catabolic process (GO:0030214)2.95611353
74plasma membrane repair (GO:0001778)2.95383957
75regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.94665193
76vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.93879786
77cell migration involved in sprouting angiogenesis (GO:0002042)2.93038215
78extracellular regulation of signal transduction (GO:1900115)2.91808845
79extracellular negative regulation of signal transduction (GO:1900116)2.91808845
80glomerular filtration (GO:0003094)2.91327121
81renal filtration (GO:0097205)2.90516911
82hippo signaling (GO:0035329)2.88683715
83positive regulation of osteoblast proliferation (GO:0033690)2.88587644
84regulation of establishment of planar polarity (GO:0090175)2.87174218
85cell migration involved in heart development (GO:0060973)2.86753884
86response to fluid shear stress (GO:0034405)2.86686876
87stress fiber assembly (GO:0043149)2.85221614
88negative regulation of cartilage development (GO:0061037)2.83831739
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82149576
90outer ear morphogenesis (GO:0042473)2.79915300
91peptidyl-glutamic acid carboxylation (GO:0017187)2.79825303
92protein carboxylation (GO:0018214)2.79825303
93substrate adhesion-dependent cell spreading (GO:0034446)2.79460769
94planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79160315
95regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.78060331
96negative regulation of BMP signaling pathway (GO:0030514)2.77134345
97insulin-like growth factor receptor signaling pathway (GO:0048009)2.75798095
98cellular response to interferon-alpha (GO:0035457)2.73632172
99regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73272518
100negative regulation of embryonic development (GO:0045992)2.72791561
101Golgi transport vesicle coating (GO:0048200)2.72698265
102COPI coating of Golgi vesicle (GO:0048205)2.72698265
103endochondral ossification (GO:0001958)2.71830954
104replacement ossification (GO:0036075)2.71830954
105negative regulation of osteoblast proliferation (GO:0033689)2.71786479
106regulation of cartilage development (GO:0061035)2.69877184
107heparan sulfate proteoglycan metabolic process (GO:0030201)2.69844604
108pericardium development (GO:0060039)2.69749401
109positive regulation of cartilage development (GO:0061036)2.69296955
110cell-substrate junction assembly (GO:0007044)2.69038933
111middle ear morphogenesis (GO:0042474)2.68843713
112G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.68283104
113negative regulation of axon extension involved in axon guidance (GO:0048843)2.68093285
114muscle cell migration (GO:0014812)2.67731691
115regulation of plasminogen activation (GO:0010755)2.66867325
116positive regulation of p38MAPK cascade (GO:1900745)2.65281239
117establishment of apical/basal cell polarity (GO:0035089)2.64253924
118positive regulation of axon extension (GO:0045773)2.63874913
119negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.63090616
120hemidesmosome assembly (GO:0031581)2.62358134
121regulation of extracellular matrix disassembly (GO:0010715)2.61871859
122chondroitin sulfate biosynthetic process (GO:0030206)2.61646986
123atrioventricular valve morphogenesis (GO:0003181)2.60847878
124substrate-dependent cell migration (GO:0006929)2.60144721
125regulation of integrin-mediated signaling pathway (GO:2001044)2.54336889
126wound healing (GO:0042060)2.54146212
127endocardial cushion development (GO:0003197)2.54001514
128cellular response to amino acid stimulus (GO:0071230)2.53772063
129regulation of chondrocyte differentiation (GO:0032330)2.53053104
130cell proliferation involved in metanephros development (GO:0072203)2.50084724
131blood vessel maturation (GO:0001955)2.50005348
132embryonic skeletal joint morphogenesis (GO:0060272)2.49994702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.44028929
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.36719375
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.06775105
4CLOCK_20551151_ChIP-Seq_293T_Human3.42560548
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.25103680
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14358411
7* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.05966375
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03624733
9* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.02528808
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.72799327
11* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.52303084
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.45514549
13CJUN_26792858_Chip-Seq_BT549_Human2.41871402
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.31964649
15CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.29411398
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.28585616
17* ESR1_21235772_ChIP-Seq_MCF-7_Human2.12368153
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.11562479
19* BRD4_25478319_ChIP-Seq_HGPS_Human2.10951902
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.05560211
21* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05010195
22* ESR2_21235772_ChIP-Seq_MCF-7_Human1.96377407
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91873226
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88347001
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.84225023
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.84225023
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.82538654
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70223500
29* EP300_21415370_ChIP-Seq_HL-1_Mouse1.69990527
30* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.62997897
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61871885
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60751812
33JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60681661
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56546197
35* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54499217
36* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54499217
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52734179
38ATF3_27146783_Chip-Seq_COLON_Human1.51673997
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50619142
40ZNF263_19887448_ChIP-Seq_K562_Human1.50437547
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50341685
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49801601
43UBF1/2_26484160_Chip-Seq_HMECs_Human1.47904718
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.47518836
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47176519
46SMC1_22415368_ChIP-Seq_MEFs_Mouse1.44469293
47JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44101366
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44025559
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43895936
50TP53_22127205_ChIP-Seq_IMR90_Human1.41662453
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41274083
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40270957
53SA1_22415368_ChIP-Seq_MEFs_Mouse1.39365980
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39192287
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38102343
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36245714
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36028656
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34300117
59TP53_16413492_ChIP-PET_HCT116_Human1.33984374
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.32382349
61* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31986846
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31494481
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.30193785
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.30193785
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29720594
66SOX2_20726797_ChIP-Seq_SW620_Human1.28290033
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.26721168
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.26017371
69* RACK7_27058665_Chip-Seq_MCF-7_Human1.25571079
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25338885
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22628782
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22614251
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22505701
74* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22455748
75TP53_18474530_ChIP-ChIP_U2OS_Human1.22303854
76LXR_22292898_ChIP-Seq_THP-1_Human1.21197604
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19320654
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19126113
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18150973
80* TP53_23651856_ChIP-Seq_MEFs_Mouse1.17941570
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16397655
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16198995
83KDM2B_26808549_Chip-Seq_K562_Human1.16007711
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14436092
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14245034
86TET1_21490601_ChIP-Seq_MESCs_Mouse1.13159771
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12246084
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12133906
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11842111
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11773971
91* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11537215
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.11492485
93* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11390790
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11288815
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.10982945
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10726835
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10217882
98KDM2B_26808549_Chip-Seq_DND41_Human1.09942473
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08128373
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06863209
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05988491
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05362758
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04026697
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01300962
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01036737
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00354314
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00253964
108ISL1_27105846_Chip-Seq_CPCs_Mouse0.99644307
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99604707
110* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99348369
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98325640
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98180505
113KLF5_25053715_ChIP-Seq_YYC3_Human0.97031237
114* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96949570
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95772344
116KDM2B_26808549_Chip-Seq_JURKAT_Human0.94260625
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.93091974
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89935138
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89517307
120VDR_24787735_ChIP-Seq_THP-1_Human0.88346728
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87392721
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86835380
123EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86677849
124RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86677849
125* RUNX1_27514584_Chip-Seq_MCF-7_Human0.85078554
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84393801
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84231482
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83103194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.46758868
2MP0005503_abnormal_tendon_morphology5.07463407
3MP0005275_abnormal_skin_tensile4.87494394
4MP0003705_abnormal_hypodermis_morpholog4.35944669
5MP0003279_aneurysm4.04959737
6MP0001958_emphysema3.53397415
7MP0009384_cardiac_valve_regurgitation3.00817547
8MP0004272_abnormal_basement_membrane2.79683985
9MP0006054_spinal_hemorrhage2.43748903
10MP0005623_abnormal_meninges_morphology2.43163689
11MP0005257_abnormal_intraocular_pressure2.32219736
12MP0003566_abnormal_cell_adhesion2.25292571
13MP0005508_abnormal_skeleton_morphology2.21719696
14MP0005023_abnormal_wound_healing2.05280263
15MP0003091_abnormal_cell_migration1.96238336
16MP0001542_abnormal_bone_strength1.95367001
17MP0002060_abnormal_skin_morphology1.91819213
18MP0002896_abnormal_bone_mineralization1.77976226
19MP0002933_joint_inflammation1.76218631
20MP0010030_abnormal_orbit_morphology1.73375566
21MP0002295_abnormal_pulmonary_circulatio1.72685764
22MP0002108_abnormal_muscle_morphology1.70465440
23MP0010352_gastrointestinal_tract_polyps1.68551826
24MP0009250_abnormal_appendicular_skeleto1.64947122
25MP0003950_abnormal_plasma_membrane1.63187111
26MP0004858_abnormal_nervous_system1.61023646
27MP0002282_abnormal_trachea_morphology1.58076279
28MP0004134_abnormal_chest_morphology1.52281836
29MP0001243_abnormal_dermal_layer1.51663807
30MP0000767_abnormal_smooth_muscle1.49594642
31MP0003385_abnormal_body_wall1.48408553
32MP0000163_abnormal_cartilage_morphology1.47250486
33MP0005390_skeleton_phenotype1.44622413
34MP0001299_abnormal_eye_distance/1.42285753
35MP0005076_abnormal_cell_differentiation1.41398814
36MP0000733_abnormal_muscle_development1.41210386
37MP0002115_abnormal_skeleton_extremities1.40355117
38MP0010368_abnormal_lymphatic_system1.32098012
39MP0003283_abnormal_digestive_organ1.26777519
40MP0003942_abnormal_urinary_system1.23536406
41MP0002168_other_aberrant_phenotype1.22093255
42MP0000013_abnormal_adipose_tissue1.22036491
43MP0002998_abnormal_bone_remodeling1.21900735
44MP0003045_fibrosis1.20819120
45MP0002113_abnormal_skeleton_development1.17588011
46MP0003300_gastrointestinal_ulcer1.13450565
47MP0003115_abnormal_respiratory_system1.12482000
48MP0001849_ear_inflammation1.11589062
49MP0001533_abnormal_skeleton_physiology1.10455046
50MP0009840_abnormal_foam_cell1.08964141
51MP0002254_reproductive_system_inflammat1.06181171
52MP0002932_abnormal_joint_morphology1.06176481
53MP0000428_abnormal_craniofacial_morphol1.04691703
54MP0003795_abnormal_bone_structure1.04499887
55MP0009278_abnormal_bone_marrow1.03669634
56MP0002877_abnormal_melanocyte_morpholog1.02221156
57MP0000751_myopathy1.02052084
58MP0009053_abnormal_anal_canal1.01763623
59MP0000534_abnormal_ureter_morphology1.01673809
60MP0001879_abnormal_lymphatic_vessel0.97515438
61MP0002089_abnormal_postnatal_growth/wei0.96988196
62MP0000750_abnormal_muscle_regeneration0.96899746
63MP0005058_abnormal_lysosome_morphology0.93917432
64MP0003755_abnormal_palate_morphology0.92600448
65MP0002128_abnormal_blood_circulation0.90256886
66MP0000003_abnormal_adipose_tissue0.89087460
67MP0002109_abnormal_limb_morphology0.88314922
68MP0010386_abnormal_urinary_bladder0.83393403
69MP0001614_abnormal_blood_vessel0.82624534
70MP0000432_abnormal_head_morphology0.82320207
71MP0003935_abnormal_craniofacial_develop0.81940047
72MP0009780_abnormal_chondrocyte_physiolo0.80011400
73MP0002249_abnormal_larynx_morphology0.79735990
74MP0005171_absent_coat_pigmentation0.79335504
75MP0000462_abnormal_digestive_system0.79203387
76MP0002116_abnormal_craniofacial_bone0.77061595
77MP0004185_abnormal_adipocyte_glucose0.76071856
78MP0005595_abnormal_vascular_smooth0.74410681
79MP0005164_abnormal_response_to0.74292468
80MP0001915_intracranial_hemorrhage0.74098793
81MP0004084_abnormal_cardiac_muscle0.72503458
82MP0000762_abnormal_tongue_morphology0.72341061
83MP0002111_abnormal_tail_morphology0.72211027
84MP0000569_abnormal_digit_pigmentation0.71885242
85MP0002925_abnormal_cardiovascular_devel0.70765654
86MP0000049_abnormal_middle_ear0.70734695
87MP0001175_abnormal_lung_morphology0.70536393
88MP0003448_altered_tumor_morphology0.70412677
89MP0002133_abnormal_respiratory_system0.68974128
90MP0005388_respiratory_system_phenotype0.68974128
91MP0003941_abnormal_skin_development0.68822441
92MP0005375_adipose_tissue_phenotype0.68761288
93MP0000343_altered_response_to0.68649774
94MP0004808_abnormal_hematopoietic_stem0.66016123
95MP0003937_abnormal_limbs/digits/tail_de0.65128505
96MP0001348_abnormal_lacrimal_gland0.64181847
97MP0000681_abnormal_thyroid_gland0.63997473
98MP0000538_abnormal_urinary_bladder0.63056803
99MP0005197_abnormal_uvea_morphology0.62508052
100MP0000858_altered_metastatic_potential0.61418131
101MP0004197_abnormal_fetal_growth/weight/0.61298479
102MP0004233_abnormal_muscle_weight0.60856567
103MP0000537_abnormal_urethra_morphology0.60757144
104MP0002233_abnormal_nose_morphology0.60087826
105MP0005409_darkened_coat_color0.59657630
106MP0000467_abnormal_esophagus_morphology0.59478396
107MP0004087_abnormal_muscle_fiber0.59449678
108MP0000759_abnormal_skeletal_muscle0.59128704
109MP0008004_abnormal_stomach_pH0.58601046
110MP0003191_abnormal_cellular_cholesterol0.57686809
111MP0005193_abnormal_anterior_eye0.56770108
112MP0000749_muscle_degeneration0.54605958
113MP0005220_abnormal_exocrine_pancreas0.54226326
114MP0002697_abnormal_eye_size0.54216274
115MP0002114_abnormal_axial_skeleton0.54031499
116MP0010771_integument_phenotype0.53747875
117MP0004883_abnormal_blood_vessel0.51016167
118MP0001270_distended_abdomen0.47877034

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.88161886
2Premature rupture of membranes (HP:0001788)7.26084520
3Ankle contracture (HP:0006466)4.60972758
4Aortic dissection (HP:0002647)4.34529758
5Neonatal short-limb short stature (HP:0008921)4.20981297
6Shallow orbits (HP:0000586)4.18702699
7Aortic aneurysm (HP:0004942)4.10731707
8Peritonitis (HP:0002586)4.02927108
9Soft skin (HP:0000977)4.00914699
10Atrophic scars (HP:0001075)3.88227537
11Abnormality of dentin (HP:0010299)3.87018227
12Cervical subluxation (HP:0003308)3.85061064
13Cerebral aneurysm (HP:0004944)3.65549656
14Bladder diverticulum (HP:0000015)3.63994707
15Dilatation of the ascending aorta (HP:0005111)3.58405845
16Broad metatarsal (HP:0001783)3.55537702
17Biconcave vertebral bodies (HP:0004586)3.54335210
18Wormian bones (HP:0002645)3.48249988
19Vertebral compression fractures (HP:0002953)3.39403917
20Genu recurvatum (HP:0002816)3.37175903
21Fragile skin (HP:0001030)3.24706490
22Blue sclerae (HP:0000592)3.20343669
23Mitral valve prolapse (HP:0001634)3.19263587
24Follicular hyperkeratosis (HP:0007502)3.16712418
25Wrist flexion contracture (HP:0001239)3.07695643
26Type 1 muscle fiber predominance (HP:0003803)3.02579073
27Spinal rigidity (HP:0003306)2.98442353
28Increased connective tissue (HP:0009025)2.91683614
29Vascular tortuosity (HP:0004948)2.85268891
30Abnormality of the acetabulum (HP:0003170)2.80971566
31Epiphyseal dysplasia (HP:0002656)2.80649898
32Overgrowth (HP:0001548)2.69275662
33Coxa vara (HP:0002812)2.59509313
34Ulnar bowing (HP:0003031)2.59113230
35Bowel diverticulosis (HP:0005222)2.58229232
36Coronal craniosynostosis (HP:0004440)2.58027860
37Hypoplastic ischia (HP:0003175)2.56418018
38Arterial tortuosity (HP:0005116)2.54844722
39Osteoarthritis (HP:0002758)2.53515263
40Hypoventilation (HP:0002791)2.51306155
41Ectopia lentis (HP:0001083)2.39201817
42Abnormal delivery (HP:0001787)2.39182408
43Elbow flexion contracture (HP:0002987)2.38908992
44Hyperextensible skin (HP:0000974)2.38698302
45Cupped ribs (HP:0000887)2.38135509
46Mildly elevated creatine phosphokinase (HP:0008180)2.37596599
47Short nail (HP:0001799)2.35623332
48Mild short stature (HP:0003502)2.34428439
49Platyspondyly (HP:0000926)2.33290673
50Joint laxity (HP:0001388)2.32685304
51Aortic valve stenosis (HP:0001650)2.31411644
52Aneurysm (HP:0002617)2.31295818
53Slender build (HP:0001533)2.31076059
54Osteolytic defects of the hand bones (HP:0009699)2.30674397
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.30674397
56Long toe (HP:0010511)2.30319180
57Wide anterior fontanel (HP:0000260)2.26441351
58Broad ribs (HP:0000885)2.23967441
59Generalized amyotrophy (HP:0003700)2.22815676
60Achilles tendon contracture (HP:0001771)2.21361022
61Tibial bowing (HP:0002982)2.18830850
62Abnormality of the ischium (HP:0003174)2.18747741
63Mesomelia (HP:0003027)2.16415347
64Mitral stenosis (HP:0001718)2.15201898
65Infantile muscular hypotonia (HP:0008947)2.14416126
66Deviation of the hallux (HP:0010051)2.13895512
67Upper limb amyotrophy (HP:0009129)2.13005754
68Distal upper limb amyotrophy (HP:0007149)2.13005754
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12895996
70Natal tooth (HP:0000695)2.10126135
71Absent frontal sinuses (HP:0002688)2.07958909
72Hallux valgus (HP:0001822)2.06334836
73Increased variability in muscle fiber diameter (HP:0003557)2.05117649
74Renal duplication (HP:0000075)2.04918321
75Round ear (HP:0100830)2.02030936
76Protruding ear (HP:0000411)2.01866032
77Breech presentation (HP:0001623)2.01719938
78Broad long bones (HP:0005622)2.01564249
79Mitral regurgitation (HP:0001653)2.00469656
80Decreased skull ossification (HP:0004331)1.99370235
81Spondylolisthesis (HP:0003302)1.99240262
82Abnormality of the Achilles tendon (HP:0005109)1.99101442
83Camptodactyly of toe (HP:0001836)1.97177600
84Premature skin wrinkling (HP:0100678)1.97001550
85Joint stiffness (HP:0001387)1.95925755
86Limited elbow extension (HP:0001377)1.95548587
87Radial bowing (HP:0002986)1.94953075
88Flat acetabular roof (HP:0003180)1.94068409
89Abnormality of the peritoneum (HP:0002585)1.93589073
90Femoral bowing (HP:0002980)1.92952963
91Inguinal hernia (HP:0000023)1.92031889
92Vitreoretinal degeneration (HP:0000655)1.91920604
93Hyperacusis (HP:0010780)1.91822571
94Delayed cranial suture closure (HP:0000270)1.91130869
95Lumbar hyperlordosis (HP:0002938)1.90599045
96Bowed forearm bones (HP:0003956)1.90170927
97Bowing of the arm (HP:0006488)1.90170927
98Nonimmune hydrops fetalis (HP:0001790)1.89840916
99Ovoid vertebral bodies (HP:0003300)1.88370772
100Spinal cord lesions (HP:0100561)1.87224630
101Syringomyelia (HP:0003396)1.87224630
102Cardiovascular calcification (HP:0011915)1.87199702
103Hand muscle atrophy (HP:0009130)1.87106009
104Small epiphyses (HP:0010585)1.86088024
105Abnormality of skull ossification (HP:0002703)1.85925443
106Beaking of vertebral bodies (HP:0004568)1.85307782
107Bell-shaped thorax (HP:0001591)1.85169738
108Thin bony cortex (HP:0002753)1.85075475
109Increased density of long bones (HP:0006392)1.84289716
110Knee flexion contracture (HP:0006380)1.84095715
111Thoracolumbar scoliosis (HP:0002944)1.83197204
112Redundant skin (HP:0001582)1.81966647
113Hip contracture (HP:0003273)1.80628323
114Flat cornea (HP:0007720)1.80145164
115Limb-girdle muscle weakness (HP:0003325)1.79680460
116Abnormality of skeletal muscle fiber size (HP:0012084)1.79320540
117Disproportionate tall stature (HP:0001519)1.79191924
118Spinal cord compression (HP:0002176)1.78900150
119Turricephaly (HP:0000262)1.78474333
120Congenital glaucoma (HP:0001087)1.78237819
121Delayed closure of the anterior fontanelle (HP:0001476)1.77040140
122Asymmetry of the thorax (HP:0001555)1.76951017
123Morphological abnormality of the middle ear (HP:0008609)1.76636530
124Abnormality of the calcaneus (HP:0008364)1.76125045
125Aortic regurgitation (HP:0001659)1.75908129
126Venous abnormality (HP:0002624)1.74710179
127Persistence of primary teeth (HP:0006335)1.71928943
128Obstructive sleep apnea (HP:0002870)1.70127556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.78728749
2TRIB34.32285293
3TTN3.96997702
4ERN13.44145521
5PDGFRA3.29907397
6LATS23.11149661
7LATS12.90296723
8SIK12.79448184
9PKN22.61919901
10EPHB22.15400074
11PAK21.99238062
12EPHA31.93156235
13RIPK11.90412713
14MAP3K31.88483159
15BMX1.82924938
16PTK61.68269358
17TRPM71.67647270
18PTK21.62163750
19CAMK1D1.61597446
20STK381.59552139
21MAP3K101.58845950
22AKT31.54360210
23PAK41.47422617
24DMPK1.46468217
25LRRK21.45346651
26SMG11.42171819
27FER1.32853065
28PDGFRB1.32243670
29STK31.31260135
30EPHA21.30715232
31RPS6KA41.30395590
32TGFBR21.29616320
33MTOR1.24979534
34RPS6KA21.23961339
35STK38L1.23079670
36EEF2K1.16233480
37PAK31.12068142
38EPHB11.11507578
39MYLK1.10123650
40PTK2B1.07624616
41CAMK1G1.07545188
42FGFR11.05859632
43TESK11.05412805
44MET1.04246790
45MAP3K61.03444450
46ROCK11.02737146
47NEK90.97832288
48TAOK20.96630898
49NTRK10.95119379
50ADRBK10.92475662
51PRPF4B0.88247972
52GRK50.86049556
53FGFR40.85717884
54PRKD30.83607960
55DYRK1B0.82225263
56CDK120.79465314
57ERBB40.79344715
58IRAK30.78439469
59RPS6KL10.76951422
60RPS6KC10.76951422
61GRK70.76167769
62MOS0.73209506
63ILK0.70850552
64PRKD20.68756997
65PIK3CG0.68323885
66NME20.68302861
67JAK10.67012748
68ICK0.66608419
69PIM20.66005040
70LIMK10.65885483
71FRK0.64362493
72ERBB30.63897154
73PAK60.63482832
74FGFR20.63355894
75TAOK10.62425268
76ARAF0.62306084
77MELK0.62139971
78MST1R0.61972167
79INSR0.61583058
80CDK60.60987833
81DAPK30.59276351
82MAPK70.59242669
83CDK80.58583048
84MAP2K10.57805671
85RPS6KA60.57509140
86PRKD10.57490525
87MARK20.56918446
88CDC42BPA0.55550145
89FGFR30.55162158
90KIT0.54491659
91PIK3CA0.52982895
92FLT30.51901754
93PRKG20.51302678
94MAP2K30.50742216
95PRKCH0.50486665
96ROCK20.48565924
97ABL20.48135308
98CAMK2G0.47522228
99LMTK20.46864884
100CHUK0.45587418
101ERBB20.44840848
102STK100.43485973
103PDPK10.43336775
104MAP3K80.42377590
105WNK10.42073941
106CAMKK20.41666892
107RET0.41286326
108SRC0.39890076
109GRK10.39330266
110CAMKK10.37937739
111CDK70.37844789
112JAK30.36955837
113HIPK20.35096481
114TGFBR10.34936101
115PAK10.34858057
116MAP3K70.34530716
117NUAK10.34458433
118MAPK10.33380278
119MAPKAPK30.32478024
120GSK3A0.32458733
121SCYL20.30942447
122MAPK40.30341775
123TESK20.30215737
124ABL10.30061125
125TBK10.29820785
126CDK90.29194372
127EGFR0.29193529
128GRK60.28869896
129KSR20.28394371
130CLK10.27974751
131CAMK2B0.26000953
132MAPKAPK20.25415321
133MAP2K20.24960761
134HCK0.23755329

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.69224347
2Focal adhesion_Homo sapiens_hsa045103.23101215
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.20455048
4Protein digestion and absorption_Homo sapiens_hsa049743.00390912
5Proteoglycans in cancer_Homo sapiens_hsa052052.40926935
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.29653742
7Amoebiasis_Homo sapiens_hsa051462.16167470
8Bladder cancer_Homo sapiens_hsa052192.07782186
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.04138976
10Malaria_Homo sapiens_hsa051442.03796192
11Adherens junction_Homo sapiens_hsa045201.99579766
12TGF-beta signaling pathway_Homo sapiens_hsa043501.96597359
13Small cell lung cancer_Homo sapiens_hsa052221.88902814
14Other glycan degradation_Homo sapiens_hsa005111.85147527
15MicroRNAs in cancer_Homo sapiens_hsa052061.79966272
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74333132
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74070951
18Hippo signaling pathway_Homo sapiens_hsa043901.69191491
19Chronic myeloid leukemia_Homo sapiens_hsa052201.68484474
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.67626902
21Dilated cardiomyopathy_Homo sapiens_hsa054141.66561035
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50609353
23Basal cell carcinoma_Homo sapiens_hsa052171.44351358
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40464901
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36077233
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.33717460
27Prion diseases_Homo sapiens_hsa050201.31574113
28Melanoma_Homo sapiens_hsa052181.31571966
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25622878
30TNF signaling pathway_Homo sapiens_hsa046681.23728632
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.22741327
32Prostate cancer_Homo sapiens_hsa052151.21943297
33Glioma_Homo sapiens_hsa052141.13199988
34Pancreatic cancer_Homo sapiens_hsa052121.13123102
35Hedgehog signaling pathway_Homo sapiens_hsa043401.11532380
36Viral myocarditis_Homo sapiens_hsa054161.07979240
37Platelet activation_Homo sapiens_hsa046111.07599516
38Shigellosis_Homo sapiens_hsa051311.06958089
39Vibrio cholerae infection_Homo sapiens_hsa051101.01451320
40Rap1 signaling pathway_Homo sapiens_hsa040151.00653687
41Toxoplasmosis_Homo sapiens_hsa051451.00185448
42HTLV-I infection_Homo sapiens_hsa051660.98032443
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96035843
44Pathways in cancer_Homo sapiens_hsa052000.95962010
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95684738
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.94662330
47Galactose metabolism_Homo sapiens_hsa000520.91263348
48Wnt signaling pathway_Homo sapiens_hsa043100.88990686
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.88474723
50p53 signaling pathway_Homo sapiens_hsa041150.88033935
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87971550
52Insulin resistance_Homo sapiens_hsa049310.87702508
53Phagosome_Homo sapiens_hsa041450.87326529
54Apoptosis_Homo sapiens_hsa042100.85476105
55HIF-1 signaling pathway_Homo sapiens_hsa040660.85341330
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84045026
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81845919
58Tight junction_Homo sapiens_hsa045300.81408252
59Lysine degradation_Homo sapiens_hsa003100.80589057
60Osteoclast differentiation_Homo sapiens_hsa043800.79944352
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79610156
62Axon guidance_Homo sapiens_hsa043600.79550297
63Renal cell carcinoma_Homo sapiens_hsa052110.78391264
64Hepatitis B_Homo sapiens_hsa051610.77343602
65N-Glycan biosynthesis_Homo sapiens_hsa005100.76499766
66Notch signaling pathway_Homo sapiens_hsa043300.75788078
67Sulfur relay system_Homo sapiens_hsa041220.75230982
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.74433544
69mTOR signaling pathway_Homo sapiens_hsa041500.72914400
70Complement and coagulation cascades_Homo sapiens_hsa046100.71585686
71Thyroid cancer_Homo sapiens_hsa052160.69778064
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.69376921
73Pentose phosphate pathway_Homo sapiens_hsa000300.68052717
74Lysosome_Homo sapiens_hsa041420.65712501
75Viral carcinogenesis_Homo sapiens_hsa052030.65101433
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64548111
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64043854
78Estrogen signaling pathway_Homo sapiens_hsa049150.63865129
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.63267255
80Endometrial cancer_Homo sapiens_hsa052130.61621740
81Salmonella infection_Homo sapiens_hsa051320.61243696
82Leishmaniasis_Homo sapiens_hsa051400.60383493
83Acute myeloid leukemia_Homo sapiens_hsa052210.59937234
84Melanogenesis_Homo sapiens_hsa049160.59587518
85Renin-angiotensin system_Homo sapiens_hsa046140.59030183
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57626420
87FoxO signaling pathway_Homo sapiens_hsa040680.57163692
88Cocaine addiction_Homo sapiens_hsa050300.56283684
89Colorectal cancer_Homo sapiens_hsa052100.56197800
90Gap junction_Homo sapiens_hsa045400.56115990
91Sphingolipid metabolism_Homo sapiens_hsa006000.55652429
92Ras signaling pathway_Homo sapiens_hsa040140.53621419
93VEGF signaling pathway_Homo sapiens_hsa043700.52625010
94Thyroid hormone synthesis_Homo sapiens_hsa049180.52577427
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51508364
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.50872373
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48858814
98Caffeine metabolism_Homo sapiens_hsa002320.48166335
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.47679667
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46559870
101ErbB signaling pathway_Homo sapiens_hsa040120.46085692
102AMPK signaling pathway_Homo sapiens_hsa041520.45129752
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45087494
104MAPK signaling pathway_Homo sapiens_hsa040100.43261987
105Insulin signaling pathway_Homo sapiens_hsa049100.43116563
106Ovarian steroidogenesis_Homo sapiens_hsa049130.43013658
107Non-small cell lung cancer_Homo sapiens_hsa052230.42259286
108Sulfur metabolism_Homo sapiens_hsa009200.41899174
109One carbon pool by folate_Homo sapiens_hsa006700.40953977
110Endocytosis_Homo sapiens_hsa041440.40914014
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38785444
112Hepatitis C_Homo sapiens_hsa051600.38599548
113GnRH signaling pathway_Homo sapiens_hsa049120.38583990
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37464149
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36647733
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.36641569
117Pertussis_Homo sapiens_hsa051330.36503451
118Prolactin signaling pathway_Homo sapiens_hsa049170.36331307
119Choline metabolism in cancer_Homo sapiens_hsa052310.34815911

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