VASH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)6.04137721
2regulation of posttranscriptional gene silencing (GO:0060147)6.04137721
3regulation of gene silencing by miRNA (GO:0060964)6.04137721
4pyrimidine nucleobase catabolic process (GO:0006208)5.67655458
5establishment of integrated proviral latency (GO:0075713)4.67491245
6chromatin remodeling at centromere (GO:0031055)4.21875365
7regulation of mitotic spindle checkpoint (GO:1903504)4.16854087
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.16854087
9negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.13801353
10negative regulation of translation, ncRNA-mediated (GO:0040033)4.13801353
11regulation of translation, ncRNA-mediated (GO:0045974)4.13801353
12nucleobase catabolic process (GO:0046113)4.01587841
13pre-miRNA processing (GO:0031054)3.97385753
14CENP-A containing nucleosome assembly (GO:0034080)3.97196373
15regulation of helicase activity (GO:0051095)3.91021540
16regulation of nuclear cell cycle DNA replication (GO:0033262)3.88401165
17response to pheromone (GO:0019236)3.87688592
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.82022043
19proximal/distal pattern formation (GO:0009954)3.75644706
20axonal fasciculation (GO:0007413)3.75247319
21L-serine metabolic process (GO:0006563)3.73564798
22DNA replication checkpoint (GO:0000076)3.69815396
23histone exchange (GO:0043486)3.67405350
24cell fate commitment involved in formation of primary germ layer (GO:0060795)3.65968811
25cell migration in hindbrain (GO:0021535)3.62276133
26establishment of viral latency (GO:0019043)3.54740891
27central nervous system projection neuron axonogenesis (GO:0021952)3.44724164
28protein localization to kinetochore (GO:0034501)3.44560584
29microtubule depolymerization (GO:0007019)3.41912482
30protein-DNA complex disassembly (GO:0032986)3.37773434
31nucleosome disassembly (GO:0006337)3.37773434
32somatic hypermutation of immunoglobulin genes (GO:0016446)3.37642730
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37642730
34peptidyl-arginine omega-N-methylation (GO:0035247)3.36020120
35DNA replication-independent nucleosome organization (GO:0034724)3.35862399
36DNA replication-independent nucleosome assembly (GO:0006336)3.35862399
37neuron recognition (GO:0008038)3.31669114
38regulation of histone H3-K9 methylation (GO:0051570)3.29330794
39layer formation in cerebral cortex (GO:0021819)3.28323878
40IMP biosynthetic process (GO:0006188)3.27812898
41metanephric mesenchyme development (GO:0072075)3.27703921
42peptidyl-arginine methylation (GO:0018216)3.27251691
43peptidyl-arginine N-methylation (GO:0035246)3.27251691
44negative regulation of gene silencing (GO:0060969)3.27125932
45paraxial mesoderm development (GO:0048339)3.26597833
46outer ear morphogenesis (GO:0042473)3.23862787
47DNA damage response, detection of DNA damage (GO:0042769)3.22680670
48regulation of gene silencing (GO:0060968)3.21726808
49regulation of cell fate specification (GO:0042659)3.18301506
50planar cell polarity pathway involved in neural tube closure (GO:0090179)3.17919261
51negative regulation of microtubule polymerization (GO:0031115)3.15972705
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.14018565
53negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13019844
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13019844
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.13019844
56negative regulation of sister chromatid segregation (GO:0033046)3.13019844
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13019844
58kidney mesenchyme development (GO:0072074)3.12788947
59DNA replication-dependent nucleosome assembly (GO:0006335)3.11280226
60DNA replication-dependent nucleosome organization (GO:0034723)3.11280226
61heterochromatin organization (GO:0070828)3.11215432
62DNA double-strand break processing (GO:0000729)3.08861570
63negative regulation of chromosome segregation (GO:0051985)3.08462985
64positive regulation of SMAD protein import into nucleus (GO:0060391)3.07160733
65axon extension involved in axon guidance (GO:0048846)3.03988346
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.03988346
67body morphogenesis (GO:0010171)3.03883133
68IMP metabolic process (GO:0046040)2.99203396
69regulation of NFAT protein import into nucleus (GO:0051532)2.99138014
70single strand break repair (GO:0000012)2.98385220
71telomere maintenance via telomerase (GO:0007004)2.98315002
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95709929
73mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.95572263
74lysine metabolic process (GO:0006553)2.94298178
75lysine catabolic process (GO:0006554)2.94298178
76regulation of telomere maintenance via telomerase (GO:0032210)2.91776054
77transcription elongation from RNA polymerase III promoter (GO:0006385)2.91634953
78termination of RNA polymerase III transcription (GO:0006386)2.91634953
79negative regulation of catenin import into nucleus (GO:0035414)2.89128051
80ATP-dependent chromatin remodeling (GO:0043044)2.89048241
81histone arginine methylation (GO:0034969)2.87472894
82atrial septum morphogenesis (GO:0060413)2.87188854
83establishment of protein localization to mitochondrial membrane (GO:0090151)2.86687116
84lung-associated mesenchyme development (GO:0060484)2.84685637
85spindle checkpoint (GO:0031577)2.83725954
86presynaptic membrane assembly (GO:0097105)2.82952188
87negative regulation of axon guidance (GO:1902668)2.82782100
88mitotic spindle checkpoint (GO:0071174)2.82160273
89embryonic skeletal joint morphogenesis (GO:0060272)2.81107096
90DNA strand elongation involved in DNA replication (GO:0006271)2.80956228
91cranial nerve morphogenesis (GO:0021602)2.80303448
92G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.79995000
93binding of sperm to zona pellucida (GO:0007339)2.79722435
94negative regulation of axon extension involved in axon guidance (GO:0048843)2.79024670
95sperm-egg recognition (GO:0035036)2.78770357
96regulation of cell fate commitment (GO:0010453)2.75308691
97epithelial cilium movement (GO:0003351)2.75015007
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73852590
99axon extension (GO:0048675)2.73715918
100regulation of chromatin silencing (GO:0031935)2.73653643
101chaperone-mediated protein transport (GO:0072321)2.73116038
102nucleobase biosynthetic process (GO:0046112)2.72473733
103mitotic metaphase plate congression (GO:0007080)2.72159502
104negative regulation of telomerase activity (GO:0051974)2.71845385
105sperm motility (GO:0030317)2.71592116
106negative regulation of DNA recombination (GO:0045910)2.70807430
107protein complex localization (GO:0031503)2.70650519
108DNA strand renaturation (GO:0000733)2.69629368
109cardiac myofibril assembly (GO:0055003)2.69484195
110protein neddylation (GO:0045116)2.68952292
111dendritic spine morphogenesis (GO:0060997)2.68757705
112chondrocyte proliferation (GO:0035988)2.68147393
113negative chemotaxis (GO:0050919)2.67525610
114head development (GO:0060322)2.66656234
115purine nucleobase biosynthetic process (GO:0009113)2.66567989
116hippo signaling (GO:0035329)2.66129441
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.65007685
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65007685
119dendrite morphogenesis (GO:0048813)2.64496527
120DNA strand elongation (GO:0022616)2.63636797
121mitotic spindle assembly checkpoint (GO:0007094)2.62925712
122regulation of sister chromatid segregation (GO:0033045)2.62743705
123regulation of mitotic sister chromatid separation (GO:0010965)2.62743705
124regulation of mitotic sister chromatid segregation (GO:0033047)2.62743705
125myoblast fusion (GO:0007520)2.62340199
126embryonic body morphogenesis (GO:0010172)2.61308589
127negative regulation of telomere maintenance (GO:0032205)2.60884313
128pseudouridine synthesis (GO:0001522)2.60309339
129somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.60150768
130isotype switching (GO:0045190)2.60150768
131somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.60150768
132negative regulation of androgen receptor signaling pathway (GO:0060766)2.59809838
133water-soluble vitamin biosynthetic process (GO:0042364)2.57493327
134lateral sprouting from an epithelium (GO:0060601)2.57061856
135glial cell proliferation (GO:0014009)2.56902367
136gastrulation with mouth forming second (GO:0001702)2.56849234
137spindle assembly checkpoint (GO:0071173)2.56196393
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56124749
139acrosome assembly (GO:0001675)2.56120178
140acrosome reaction (GO:0007340)2.55667904
141protein localization to chromosome, centromeric region (GO:0071459)2.55416150
142regulation of chromosome segregation (GO:0051983)2.54645634
143ncRNA catabolic process (GO:0034661)2.54577923
144negative regulation of mitosis (GO:0045839)2.54468976
145response to X-ray (GO:0010165)2.53796931
146energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53040690
147ATP synthesis coupled proton transport (GO:0015986)2.53040690
148somatic recombination of immunoglobulin gene segments (GO:0016447)2.52660286
149regulation of sarcomere organization (GO:0060297)2.51932861
150postreplication repair (GO:0006301)2.51223942
151nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50746468
152ventricular cardiac muscle cell development (GO:0055015)2.50245632
153establishment of nucleus localization (GO:0040023)2.49726422
154cochlea morphogenesis (GO:0090103)2.48852395
155hippocampus development (GO:0021766)2.47982033
156cell migration involved in heart development (GO:0060973)2.47541720
157limb bud formation (GO:0060174)2.46263574
158negative regulation of organelle assembly (GO:1902116)2.44549582
159regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.42617907
160cilium or flagellum-dependent cell motility (GO:0001539)2.42241432
161mitotic sister chromatid cohesion (GO:0007064)2.41238822
162negative regulation of oligodendrocyte differentiation (GO:0048715)2.40719950
163cardiac chamber formation (GO:0003207)2.40663040
164central nervous system neuron axonogenesis (GO:0021955)2.40591096
165urogenital system development (GO:0001655)2.39108460
166RNA localization (GO:0006403)2.37358570
167positive regulation of gastrulation (GO:2000543)2.36641174
168nuclear pore complex assembly (GO:0051292)2.35612236
169atrial cardiac muscle cell action potential (GO:0086014)2.34922729
170nuclear pore organization (GO:0006999)2.34691277
171axonemal dynein complex assembly (GO:0070286)2.34016076
172regulation of heart morphogenesis (GO:2000826)2.30800159
173embryonic forelimb morphogenesis (GO:0035115)2.30782085
174retinal ganglion cell axon guidance (GO:0031290)2.29636632
175cardiac ventricle formation (GO:0003211)2.28475838
176cell-cell recognition (GO:0009988)2.27694931
177mesenchymal to epithelial transition (GO:0060231)2.27653090
178dorsal/ventral axis specification (GO:0009950)2.27187496
179generation of neurons (GO:0048699)2.27070985
180embryonic cranial skeleton morphogenesis (GO:0048701)2.26771020
181establishment of planar polarity (GO:0001736)2.26720799
182establishment of tissue polarity (GO:0007164)2.26720799
183cell recognition (GO:0008037)2.26120202
184cardiac right ventricle morphogenesis (GO:0003215)2.25602495
185neuron projection extension (GO:1990138)2.25284218
186cell proliferation in forebrain (GO:0021846)2.25060370
187neuron migration (GO:0001764)2.24043317
188histone H2A acetylation (GO:0043968)2.24022632
189forelimb morphogenesis (GO:0035136)2.23041623
190kidney morphogenesis (GO:0060993)2.22402786
191bone trabecula formation (GO:0060346)2.22256978
192mesenchyme development (GO:0060485)2.22245371
193fusion of sperm to egg plasma membrane (GO:0007342)2.21915631
194camera-type eye morphogenesis (GO:0048593)2.21313471
195regulation of secondary heart field cardioblast proliferation (GO:0003266)2.20848132
196regulation of cardioblast proliferation (GO:0003264)2.20848132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.72113271
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.30971827
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.50858018
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36731548
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17825725
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.06610787
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97805028
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87600475
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.81438880
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.79163704
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.72880553
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.71803617
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.70721609
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.56641344
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.56641344
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.56641344
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.55517231
18VDR_22108803_ChIP-Seq_LS180_Human2.52323149
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.46117916
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39905337
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37520181
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35442135
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32173947
24ZNF274_21170338_ChIP-Seq_K562_Hela2.17507312
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17440918
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16528052
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14009270
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05302266
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.04720978
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02066615
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.01595246
32* EWS_26573619_Chip-Seq_HEK293_Human2.01110787
33ELK1_19687146_ChIP-ChIP_HELA_Human1.98331683
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.93681196
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92099510
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91125335
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90289036
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87446152
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87388365
40* RNF2_27304074_Chip-Seq_ESCs_Mouse1.85311965
41* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83136438
42* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83136438
43* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83129032
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.80358832
45* RNF2_27304074_Chip-Seq_NSC_Mouse1.78111128
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75693516
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73779141
48IGF1R_20145208_ChIP-Seq_DFB_Human1.73278254
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.71046180
50MYC_18940864_ChIP-ChIP_HL60_Human1.70394722
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68867769
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67967131
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.67613340
54* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66756979
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.64539043
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63011741
57* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62391980
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61096984
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.60725695
60P300_19829295_ChIP-Seq_ESCs_Human1.60196115
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.60039534
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.59205058
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.57707433
64* RING1B_27294783_Chip-Seq_NPCs_Mouse1.56762280
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56486415
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54474232
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53002565
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.51305081
69* RING1B_27294783_Chip-Seq_ESCs_Mouse1.50929386
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49633345
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48920219
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48774153
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48338053
74* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47435456
75TAF15_26573619_Chip-Seq_HEK293_Human1.47211219
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46320193
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46086936
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42688229
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38996550
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38822595
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37008973
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36489361
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35921035
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35096936
85FOXP3_21729870_ChIP-Seq_TREG_Human1.31914233
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30643884
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.30218702
88IRF1_19129219_ChIP-ChIP_H3396_Human1.29971706
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29812616
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29810504
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29233383
92TTF2_22483619_ChIP-Seq_HELA_Human1.28573927
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28270661
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28068305
95FUS_26573619_Chip-Seq_HEK293_Human1.27919259
96* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27788647
97TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27195339
98VDR_23849224_ChIP-Seq_CD4+_Human1.25645317
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.25292637
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25111188
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25012351
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24498178
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23815911
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23221272
105TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22431910
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22209782
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.21600432
108ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20961056
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18652718
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17964202
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17468426
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17468426
113E2F7_22180533_ChIP-Seq_HELA_Human1.16791156
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16663347
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14728041
116* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14403689
117* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.13914014
118* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12832286
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11922449
120SOX2_16153702_ChIP-ChIP_HESCs_Human1.11289102
121SOX9_26525672_Chip-Seq_HEART_Mouse1.10842689
122TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08753333
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08706483
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08529517
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08358162
126TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07744207
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06368631
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04814855
129SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04410843
130XRN2_22483619_ChIP-Seq_HELA_Human1.04242527
131REST_21632747_ChIP-Seq_MESCs_Mouse1.03995254
132* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03445076
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02271371
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01044801
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00954127
136POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.00886012
137GBX2_23144817_ChIP-Seq_PC3_Human1.00811526
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00261991
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99537384
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98033234
141* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98004134
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95478319
143NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94319803
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.92325147
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91275863
146PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90617452
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90493281
148SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89992092
149TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87895039
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.87454601
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.87260254
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86416463
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85164223
154AR_21572438_ChIP-Seq_LNCaP_Human0.84953004
155GATA1_26923725_Chip-Seq_HPCs_Mouse0.83855557
156* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83550010
157WDR5_24793694_ChIP-Seq_LNCAP_Human0.83547330
158CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82231525
159FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81306964
160TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80003895
161ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78603481
162TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78004154
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.77796119
164WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77102920
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.76982979
166POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.76753125
167ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76742787
168CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76329673
169GF1B_26923725_Chip-Seq_HPCs_Mouse0.75864570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.93947730
2MP0003941_abnormal_skin_development3.48112570
3MP0003122_maternal_imprinting3.45441698
4MP0008877_abnormal_DNA_methylation3.31604085
5MP0003693_abnormal_embryo_hatching3.15932736
6MP0006292_abnormal_olfactory_placode3.05502778
7MP0002254_reproductive_system_inflammat3.04718816
8MP0003121_genomic_imprinting2.72729708
9MP0008058_abnormal_DNA_repair2.70456495
10MP0000537_abnormal_urethra_morphology2.68988531
11MP0010094_abnormal_chromosome_stability2.48520166
12MP0003942_abnormal_urinary_system2.47785685
13MP0004957_abnormal_blastocyst_morpholog2.47709559
14MP0003385_abnormal_body_wall2.38866610
15MP0003123_paternal_imprinting2.37083790
16MP0000778_abnormal_nervous_system2.34945039
17MP0000049_abnormal_middle_ear2.32177880
18MP0000569_abnormal_digit_pigmentation2.28144784
19MP0008057_abnormal_DNA_replication2.27433391
20MP0001188_hyperpigmentation2.25949938
21MP0009053_abnormal_anal_canal2.20576705
22MP0003111_abnormal_nucleus_morphology2.19657369
23MP0003718_maternal_effect2.10601289
24MP0003136_yellow_coat_color2.00763050
25MP0000534_abnormal_ureter_morphology1.97711062
26MP0002282_abnormal_trachea_morphology1.91098395
27MP0005410_abnormal_fertilization1.89530427
28MP0003115_abnormal_respiratory_system1.88657043
29MP0002249_abnormal_larynx_morphology1.87776823
30MP0005248_abnormal_Harderian_gland1.84991349
31MP0005503_abnormal_tendon_morphology1.84299222
32MP0008789_abnormal_olfactory_epithelium1.82393188
33MP0009250_abnormal_appendicular_skeleto1.82295954
34MP0003077_abnormal_cell_cycle1.76531312
35MP0005623_abnormal_meninges_morphology1.71671754
36MP0003937_abnormal_limbs/digits/tail_de1.66471242
37MP0005423_abnormal_somatic_nervous1.65549057
38MP0003755_abnormal_palate_morphology1.63618711
39MP0002653_abnormal_ependyma_morphology1.62846545
40MP0003119_abnormal_digestive_system1.61213820
41MP0004233_abnormal_muscle_weight1.56530967
42MP0003861_abnormal_nervous_system1.53727919
43MP0002932_abnormal_joint_morphology1.53360204
44MP0006072_abnormal_retinal_apoptosis1.49018899
45MP0002938_white_spotting1.48620954
46MP0001529_abnormal_vocalization1.48373849
47MP0003315_abnormal_perineum_morphology1.48157557
48MP0001485_abnormal_pinna_reflex1.43523830
49MP0002184_abnormal_innervation1.41864386
50MP0003935_abnormal_craniofacial_develop1.40187667
51MP0002116_abnormal_craniofacial_bone1.39098063
52MP0000733_abnormal_muscle_development1.36418403
53MP0003787_abnormal_imprinting1.36402030
54MP0002233_abnormal_nose_morphology1.35851068
55MP0002102_abnormal_ear_morphology1.35097537
56MP0003567_abnormal_fetal_cardiomyocyte1.33611071
57MP0003938_abnormal_ear_development1.32382928
58MP0002736_abnormal_nociception_after1.31080149
59MP0000428_abnormal_craniofacial_morphol1.29707106
60MP0000566_synostosis1.27762029
61MP0000516_abnormal_urinary_system1.27355714
62MP0005367_renal/urinary_system_phenotyp1.27355714
63MP0006276_abnormal_autonomic_nervous1.27344737
64MP0002751_abnormal_autonomic_nervous1.24291276
65MP0002234_abnormal_pharynx_morphology1.24026206
66MP0001984_abnormal_olfaction1.23943726
67MP0004197_abnormal_fetal_growth/weight/1.22759035
68MP0001299_abnormal_eye_distance/1.22113988
69MP0005187_abnormal_penis_morphology1.22061635
70MP0005394_taste/olfaction_phenotype1.21085141
71MP0005499_abnormal_olfactory_system1.21085141
72MP0000751_myopathy1.20474381
73MP0000579_abnormal_nail_morphology1.16515774
74MP0003880_abnormal_central_pattern1.15304292
75MP0002081_perinatal_lethality1.12699749
76MP0008438_abnormal_cutaneous_collagen1.12161213
77MP0004270_analgesia1.12131180
78MP0003890_abnormal_embryonic-extraembry1.11110851
79MP0001730_embryonic_growth_arrest1.11056556
80MP0002085_abnormal_embryonic_tissue1.07993316
81MP0003698_abnormal_male_reproductive1.07874140
82MP0009703_decreased_birth_body1.07817302
83MP0002114_abnormal_axial_skeleton1.07505294
84MP0002084_abnormal_developmental_patter1.06213971
85MP0004145_abnormal_muscle_electrophysio1.05502463
86MP0002177_abnormal_outer_ear1.05110135
87MP0000631_abnormal_neuroendocrine_gland1.04250720
88MP0001849_ear_inflammation1.04194556
89MP0005257_abnormal_intraocular_pressure1.04100989
90MP0002734_abnormal_mechanical_nocicepti1.03001692
91MP0002697_abnormal_eye_size1.01287819
92MP0001286_abnormal_eye_development1.01224612
93MP0002152_abnormal_brain_morphology1.00518394
94MP0000955_abnormal_spinal_cord1.00055345
95MP0003137_abnormal_impulse_conducting0.99945216
96MP0005508_abnormal_skeleton_morphology0.99885423
97MP0001177_atelectasis0.97156715
98MP0005645_abnormal_hypothalamus_physiol0.97089869
99MP0001293_anophthalmia0.95457010
100MP0009697_abnormal_copulation0.94503837
101MP0000432_abnormal_head_morphology0.94400037
102MP0004133_heterotaxia0.94390472
103MP0003705_abnormal_hypodermis_morpholog0.93567273
104MP0000350_abnormal_cell_proliferation0.93263734
105MP0004811_abnormal_neuron_physiology0.92707737
106MP0009379_abnormal_foot_pigmentation0.92124189
107MP0002109_abnormal_limb_morphology0.91845013
108MP0003878_abnormal_ear_physiology0.91105220
109MP0005377_hearing/vestibular/ear_phenot0.91105220
110MP0001968_abnormal_touch/_nociception0.90577480
111MP0004272_abnormal_basement_membrane0.89559371
112MP0004084_abnormal_cardiac_muscle0.88824708
113MP0003011_delayed_dark_adaptation0.88785953
114MP0002735_abnormal_chemical_nociception0.87810545
115MP0002111_abnormal_tail_morphology0.86267357
116MP0006035_abnormal_mitochondrial_morpho0.85451789
117MP0000647_abnormal_sebaceous_gland0.84989498
118MP0009672_abnormal_birth_weight0.84034333
119MP0004134_abnormal_chest_morphology0.82940337
120MP0001346_abnormal_lacrimal_gland0.81707859
121MP0002837_dystrophic_cardiac_calcinosis0.81018614
122MP0005076_abnormal_cell_differentiation0.80915009
123MP0004859_abnormal_synaptic_plasticity0.80896194
124MP0005551_abnormal_eye_electrophysiolog0.79845966
125MP0002092_abnormal_eye_morphology0.79663782
126MP0008007_abnormal_cellular_replicative0.79309498
127MP0002163_abnormal_gland_morphology0.79001138
128MP0001486_abnormal_startle_reflex0.78005526
129MP0001697_abnormal_embryo_size0.77556249
130MP0000026_abnormal_inner_ear0.76932685
131MP0003950_abnormal_plasma_membrane0.76706724
132MP0009745_abnormal_behavioral_response0.75989759
133MP0002882_abnormal_neuron_morphology0.75429998
134MP0002822_catalepsy0.75383671
135MP0001929_abnormal_gametogenesis0.75258028
136MP0002210_abnormal_sex_determination0.75003705
137MP0001270_distended_abdomen0.74845680
138MP0005253_abnormal_eye_physiology0.74676277
139MP0005391_vision/eye_phenotype0.74531761
140MP0000759_abnormal_skeletal_muscle0.74100508
141MP0008770_decreased_survivor_rate0.73363332
142MP0005380_embryogenesis_phenotype0.73222215
143MP0001672_abnormal_embryogenesis/_devel0.73222215
144MP0009046_muscle_twitch0.72882481
145MP0002752_abnormal_somatic_nervous0.72690312
146MP0008932_abnormal_embryonic_tissue0.72165541
147MP0002080_prenatal_lethality0.69451190
148MP0002090_abnormal_vision0.68985552

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.16010870
2Short 4th metacarpal (HP:0010044)4.16010870
3Septo-optic dysplasia (HP:0100842)3.57325341
4Renal duplication (HP:0000075)3.42248597
5Abnormality of the 4th metacarpal (HP:0010012)3.19939027
6Hepatoblastoma (HP:0002884)2.94583537
7Birth length less than 3rd percentile (HP:0003561)2.83346095
8Dynein arm defect of respiratory motile cilia (HP:0012255)2.81904348
9Absent/shortened dynein arms (HP:0200106)2.81904348
10Hyperglycinemia (HP:0002154)2.71554322
11Abnormal lung lobation (HP:0002101)2.65251354
12Wrist flexion contracture (HP:0001239)2.58400174
13Meckel diverticulum (HP:0002245)2.57441305
14Exercise-induced muscle cramps (HP:0003710)2.50672506
15Absent septum pellucidum (HP:0001331)2.48703264
16Abnormality of the ileum (HP:0001549)2.43772035
17Shallow orbits (HP:0000586)2.43054798
18Stenosis of the external auditory canal (HP:0000402)2.41409220
19Abnormality of the septum pellucidum (HP:0007375)2.38682777
20Pendular nystagmus (HP:0012043)2.37196056
21Poor suck (HP:0002033)2.36323862
22Asymmetry of the thorax (HP:0001555)2.35138989
23Abnormal hair whorl (HP:0010721)2.33295334
24Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.31964271
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31587733
26Calf muscle hypertrophy (HP:0008981)2.31494776
27Amyotrophic lateral sclerosis (HP:0007354)2.29614621
28Hyperglycinuria (HP:0003108)2.24552031
29Morphological abnormality of the middle ear (HP:0008609)2.23965887
30Abnormality of glycine metabolism (HP:0010895)2.23821490
31Abnormality of serine family amino acid metabolism (HP:0010894)2.23821490
32Optic nerve hypoplasia (HP:0000609)2.20540506
33Patellar aplasia (HP:0006443)2.19275185
34Choanal stenosis (HP:0000452)2.19195897
35Trigonocephaly (HP:0000243)2.19179666
36Renovascular hypertension (HP:0100817)2.19122655
37Shoulder girdle muscle weakness (HP:0003547)2.19008271
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16711244
39Maternal diabetes (HP:0009800)2.16596913
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.13876851
41Abnormality of serum amino acid levels (HP:0003112)2.11258799
42Abnormality of dentin (HP:0010299)2.10668206
43Chronic bronchitis (HP:0004469)2.10526072
44Hyperacusis (HP:0010780)2.08552372
45Intestinal atresia (HP:0011100)2.07734310
46Neoplasm of the adrenal cortex (HP:0100641)2.07592682
47Midline defect of the nose (HP:0004122)2.06574133
48Hypoplasia of the brainstem (HP:0002365)2.06558821
49Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06558821
50Chromsome breakage (HP:0040012)2.04940042
51Type 2 muscle fiber atrophy (HP:0003554)2.02973216
52Spastic diplegia (HP:0001264)2.02546717
53Decreased muscle mass (HP:0003199)2.01672757
54Microglossia (HP:0000171)2.00650922
55Anophthalmia (HP:0000528)2.00642838
56Muscle hypertrophy of the lower extremities (HP:0008968)1.99719743
57Lymphangioma (HP:0100764)1.99608266
58Carpal bone hypoplasia (HP:0001498)1.99170206
59Aplasia/Hypoplasia of the patella (HP:0006498)1.99059535
60High anterior hairline (HP:0009890)1.97977439
61Abnormality of chromosome stability (HP:0003220)1.97653341
62Glioma (HP:0009733)1.96754909
63Sacral dimple (HP:0000960)1.96447833
64Neoplasm of the heart (HP:0100544)1.95612604
65Multiple enchondromatosis (HP:0005701)1.95326249
66Abnormal number of incisors (HP:0011064)1.95222189
67Scrotal hypoplasia (HP:0000046)1.94578443
68Elfin facies (HP:0004428)1.93958759
69Increased nuchal translucency (HP:0010880)1.93412872
70Abolished electroretinogram (ERG) (HP:0000550)1.92939472
71Breast aplasia (HP:0100783)1.92321824
72Methylmalonic acidemia (HP:0002912)1.91809701
73Protrusio acetabuli (HP:0003179)1.91470857
74Flat cornea (HP:0007720)1.90685119
75Inability to walk (HP:0002540)1.90417151
76Dandy-Walker malformation (HP:0001305)1.90271622
77Astrocytoma (HP:0009592)1.90267310
78Abnormality of the astrocytes (HP:0100707)1.90267310
79Bladder diverticulum (HP:0000015)1.90157773
80Abnormality of homocysteine metabolism (HP:0010919)1.90009262
81Homocystinuria (HP:0002156)1.90009262
82Reticulocytopenia (HP:0001896)1.89241117
83Esophageal atresia (HP:0002032)1.89164972
84Cutaneous finger syndactyly (HP:0010554)1.89031562
85Abnormality of the aortic arch (HP:0012303)1.88566374
86Acute necrotizing encephalopathy (HP:0006965)1.88216379
87Pancreatic cysts (HP:0001737)1.87606207
88Overriding aorta (HP:0002623)1.86976493
89Medulloblastoma (HP:0002885)1.85557273
90Lissencephaly (HP:0001339)1.85472302
91Pancreatic fibrosis (HP:0100732)1.84206345
92Increased hepatocellular lipid droplets (HP:0006565)1.83286210
93Fetal akinesia sequence (HP:0001989)1.82858646
94Horseshoe kidney (HP:0000085)1.82307517
95Supernumerary spleens (HP:0009799)1.81577948
96Gastrointestinal atresia (HP:0002589)1.81452263
97Type 1 muscle fiber predominance (HP:0003803)1.79794678
98Abnormality of the clitoris (HP:0000056)1.79643509
99Buphthalmos (HP:0000557)1.78653452
100Absent eyebrow (HP:0002223)1.78487385
101Duodenal stenosis (HP:0100867)1.78433716
102Small intestinal stenosis (HP:0012848)1.78433716
103Absent radius (HP:0003974)1.78090123
104Abnormality of the phalanges of the hallux (HP:0010057)1.77302632
105Rhabdomyosarcoma (HP:0002859)1.76701929
106Acute encephalopathy (HP:0006846)1.76616420
107Abnormal respiratory motile cilium morphology (HP:0005938)1.76039431
108Abnormal respiratory epithelium morphology (HP:0012253)1.76039431
109Abnormality of the duodenum (HP:0002246)1.75468906
110Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75238711
111Hypoplasia of the pons (HP:0012110)1.75139877
112Absent forearm bone (HP:0003953)1.74552983
113Aplasia involving forearm bones (HP:0009822)1.74552983
114Protruding tongue (HP:0010808)1.74103071
115Aplasia/Hypoplasia of the breasts (HP:0010311)1.73443897
116Aqueductal stenosis (HP:0002410)1.73268851
117Spina bifida occulta (HP:0003298)1.72607505
118Coronal craniosynostosis (HP:0004440)1.72013461
119Pachygyria (HP:0001302)1.71872728
120Facial cleft (HP:0002006)1.71589480
121Triphalangeal thumb (HP:0001199)1.71336137
122Aplasia of the musculature (HP:0100854)1.70146294
123Cutaneous syndactyly (HP:0012725)1.69073940
124Abnormality of the preputium (HP:0100587)1.69046487
125Muscle fiber atrophy (HP:0100295)1.68603085
126Ependymoma (HP:0002888)1.68293287
127Abnormality of the labia minora (HP:0012880)1.68206078
128Neoplasm of the colon (HP:0100273)1.68137461
129Hypoplastic female external genitalia (HP:0012815)1.67888808
130Lipid accumulation in hepatocytes (HP:0006561)1.67619561
131Megalocornea (HP:0000485)1.66843238
132Renal hypoplasia (HP:0000089)1.66804197
133Overgrowth (HP:0001548)1.66477897
134Labial hypoplasia (HP:0000066)1.66186480
135Increased number of teeth (HP:0011069)1.65935975
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.65748296
137Clitoromegaly (HP:0000057)1.65689783
138Hypogonadotrophic hypogonadism (HP:0000044)1.65277294
139Myelomeningocele (HP:0002475)1.64974443
140Abnormality of the pons (HP:0007361)1.64716855
141Bilateral microphthalmos (HP:0007633)1.64515841
142Impulsivity (HP:0100710)1.64262828
143Deviation of the hallux (HP:0010051)1.63913184
144Embryonal renal neoplasm (HP:0011794)1.63903993
145Heterotopia (HP:0002282)1.63710599
146Syringomyelia (HP:0003396)1.63705070
147Spinal cord lesions (HP:0100561)1.63705070
148Bowel diverticulosis (HP:0005222)1.63567472
149Ectopic kidney (HP:0000086)1.63414958
150Nephronophthisis (HP:0000090)1.61809013
151Adducted thumb (HP:0001181)1.60580168
152Pelvic girdle muscle weakness (HP:0003749)1.60381716
153Nephroblastoma (Wilms tumor) (HP:0002667)1.59897785
154Pointed chin (HP:0000307)1.58576182
155Subacute progressive viral hepatitis (HP:0006572)1.58073670
156Abnormality of the intervertebral disk (HP:0005108)1.57901166
157Congenital diaphragmatic hernia (HP:0000776)1.57778518
158Bell-shaped thorax (HP:0001591)1.57188264
159Atresia of the external auditory canal (HP:0000413)1.56671982
160Hallux valgus (HP:0001822)1.55139356
161Cortical dysplasia (HP:0002539)1.55034667
162Broad toe (HP:0001837)1.54241378
163Abnormality of the calf musculature (HP:0001430)1.53859565
164Omphalocele (HP:0001539)1.53259493
165Hypoplastic heart (HP:0001961)1.53050908
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.52941313
167Centrally nucleated skeletal muscle fibers (HP:0003687)1.52824635
168Bifid tongue (HP:0010297)1.51818774
169Intellectual disability, moderate (HP:0002342)1.51625171
170Colon cancer (HP:0003003)1.51287447
171Abnormal respiratory motile cilium physiology (HP:0012261)1.50057040
172Abnormality of abdominal situs (HP:0011620)1.48106898
173Abdominal situs inversus (HP:0003363)1.48106898
174Germ cell neoplasia (HP:0100728)1.46931437
175Wide cranial sutures (HP:0010537)1.45938632
176Papillary thyroid carcinoma (HP:0002895)1.44896040
177Bicornuate uterus (HP:0000813)1.44701286
178Patellar dislocation (HP:0002999)1.44578169
179Megalencephaly (HP:0001355)1.44537042
180Calcaneovalgus deformity (HP:0001848)1.44083829
181Telecanthus (HP:0000506)1.43942897
182Abnormality of the musculature of the pelvis (HP:0001469)1.43010970
183Abnormality of the hip-girdle musculature (HP:0001445)1.43010970
184Down-sloping shoulders (HP:0200021)1.42086187
185Exostoses (HP:0100777)1.41619543
186Increased density of long bones (HP:0006392)1.40862415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.32809866
2TNIK3.34742301
3TESK13.03273963
4ZAK2.99305875
5ERBB32.96630989
6EPHB22.86463651
7DYRK22.80322726
8VRK22.79025202
9TTK2.67545757
10TSSK62.54780684
11TAF12.44036764
12ICK2.23981637
13PRKD32.13575545
14LATS22.12146494
15MAPK132.07399429
16LIMK12.04558219
17DDR21.99709461
18MAP3K101.97820305
19VRK11.96822028
20KSR11.93847457
21NUAK11.82036265
22SRPK11.79531932
23MKNK11.76829861
24CDK191.74598163
25PLK41.64781310
26NTRK21.64153786
27UHMK11.53671524
28TRIM281.50450296
29MINK11.48344064
30PASK1.46838620
31PDK41.39206878
32PDK31.39206878
33BCR1.34928274
34PDGFRA1.31725390
35PAK61.29863122
36WEE11.28379710
37FGFR21.23350714
38TGFBR11.23287046
39MAPKAPK51.22375018
40TESK21.22080270
41PBK1.20772849
42PAK21.18869656
43WNK31.16373131
44DYRK31.13356135
45DYRK1B1.12961221
46ACVR1B1.11941100
47ILK1.11201476
48TYRO31.10694343
49FGFR11.10323224
50ERBB21.09862118
51NME11.07940244
52SIK21.07504832
53LATS11.07502208
54PHKG21.07164589
55PHKG11.07164589
56BRSK21.06538411
57CDC71.05643194
58CDK181.04089641
59PAK31.03236358
60OXSR11.01883854
61STK161.01733923
62EPHA31.01643896
63OBSCN1.00160661
64CDK140.99092331
65MUSK0.98724428
66CDK150.95997981
67STK30.95331196
68BMPR1B0.94395424
69MKNK20.94017060
70MST40.93441541
71TLK10.93408312
72MAP4K20.93169044
73PKN20.92933901
74ALK0.92903428
75TRIB30.92861996
76GRK10.91292615
77PLK30.91241438
78CDK80.83505504
79ROCK10.82633896
80CDK11A0.81628635
81RPS6KA20.81300154
82PLK20.80800979
83SIK30.80408134
84PRKCG0.77842996
85NEK10.77546553
86ADRBK20.76932208
87MAP3K90.76265134
88BRSK10.74080424
89INSRR0.73702363
90MAP2K70.73658419
91CSNK1A1L0.73394239
92DYRK1A0.72202270
93EEF2K0.71515828
94ATM0.71304432
95CHEK20.70122954
96CSNK1G30.69492497
97MTOR0.69479993
98EIF2AK30.68797245
99RPS6KA40.68710836
100PNCK0.68669037
101ATR0.68084138
102MAP3K40.66158845
103FRK0.65896221
104STK38L0.65706868
105BUB10.65214990
106PAK40.65058766
107AURKB0.64886417
108NEK20.62032811
109NLK0.61735478
110BRD40.61028499
111CSNK1E0.60916866
112PTK2B0.59710247
113RIPK10.59132596
114CSNK1G20.59005572
115ROCK20.58241987
116ERBB40.57040628
117PRKDC0.54125311
118MAPK90.54077888
119TTN0.54072444
120PRKCZ0.53812487
121TIE10.53551319
122EIF2AK10.53392842
123EIF2AK20.52654237
124CDC42BPA0.52471040
125FLT30.51687787
126CDK10.50427187
127PTK60.50410574
128CHEK10.49684352
129PAK10.48741160
130CDK70.48129015
131MARK20.46798506
132PRKCE0.46781459
133CSNK1D0.46518942
134PKN10.45855340
135CCNB10.45191003
136PLK10.44849906
137CASK0.44221700
138RPS6KA10.44217891
139CAMK1G0.43899407
140AURKA0.43635566
141CDK50.43588747
142FER0.43544609
143CDK20.43021689
144CSNK2A20.41707641
145DAPK10.41179578
146CDK30.40840436
147CSNK2A10.40708495
148CSNK1G10.40145559
149AKT20.40069346
150STK240.39243799
151SMG10.37904548
152CAMK1D0.37067461
153CSNK1A10.36379777
154PRKACB0.36309282
155RPS6KA50.34370469

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.91603351
2Selenocompound metabolism_Homo sapiens_hsa004502.85283221
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84191074
4Basal cell carcinoma_Homo sapiens_hsa052172.79443653
5Non-homologous end-joining_Homo sapiens_hsa034502.59896784
6Hippo signaling pathway_Homo sapiens_hsa043902.32632212
7Homologous recombination_Homo sapiens_hsa034402.32409718
8Hedgehog signaling pathway_Homo sapiens_hsa043402.31042314
9Ribosome_Homo sapiens_hsa030102.25422868
10mRNA surveillance pathway_Homo sapiens_hsa030152.21911123
11Protein export_Homo sapiens_hsa030602.18192408
12One carbon pool by folate_Homo sapiens_hsa006702.08924563
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.02307287
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.98085204
15Spliceosome_Homo sapiens_hsa030401.94849743
16Parkinsons disease_Homo sapiens_hsa050121.94745523
17Oxidative phosphorylation_Homo sapiens_hsa001901.90718388
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83186411
19Endometrial cancer_Homo sapiens_hsa052131.79845660
20Colorectal cancer_Homo sapiens_hsa052101.78417837
21Cell cycle_Homo sapiens_hsa041101.76725768
22Viral myocarditis_Homo sapiens_hsa054161.75592881
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.73744728
24Cardiac muscle contraction_Homo sapiens_hsa042601.72996230
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72669627
26Wnt signaling pathway_Homo sapiens_hsa043101.69713440
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69605457
28Oocyte meiosis_Homo sapiens_hsa041141.68016929
29Dilated cardiomyopathy_Homo sapiens_hsa054141.66836525
30RNA transport_Homo sapiens_hsa030131.65440685
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.56244054
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54484070
33MicroRNAs in cancer_Homo sapiens_hsa052061.53262456
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44530167
35Steroid biosynthesis_Homo sapiens_hsa001001.43447958
36Propanoate metabolism_Homo sapiens_hsa006401.42702633
37Adherens junction_Homo sapiens_hsa045201.41268311
38Gap junction_Homo sapiens_hsa045401.36812772
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36407032
40Pyruvate metabolism_Homo sapiens_hsa006201.34185995
41Tight junction_Homo sapiens_hsa045301.32859598
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32635822
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31941135
44TGF-beta signaling pathway_Homo sapiens_hsa043501.31840602
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24114923
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22368380
47Proteoglycans in cancer_Homo sapiens_hsa052051.19251628
48Phototransduction_Homo sapiens_hsa047441.18960594
49Pyrimidine metabolism_Homo sapiens_hsa002401.18063161
50Melanogenesis_Homo sapiens_hsa049161.17704469
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17519478
52Notch signaling pathway_Homo sapiens_hsa043301.15899692
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.15216073
54Alzheimers disease_Homo sapiens_hsa050101.14185807
55Purine metabolism_Homo sapiens_hsa002301.10598083
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09666219
57Focal adhesion_Homo sapiens_hsa045101.08178922
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07934069
59Vitamin B6 metabolism_Homo sapiens_hsa007501.06200628
60Renal cell carcinoma_Homo sapiens_hsa052111.04476736
61Chronic myeloid leukemia_Homo sapiens_hsa052201.03712015
62Glioma_Homo sapiens_hsa052141.00349641
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98460485
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96803711
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96285663
66Nicotine addiction_Homo sapiens_hsa050330.95401181
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95084802
68ErbB signaling pathway_Homo sapiens_hsa040120.94070115
69Alcoholism_Homo sapiens_hsa050340.93938283
70Taste transduction_Homo sapiens_hsa047420.91171432
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.91041653
72mTOR signaling pathway_Homo sapiens_hsa041500.90205629
73HTLV-I infection_Homo sapiens_hsa051660.90152761
74Pathways in cancer_Homo sapiens_hsa052000.89192820
75Dopaminergic synapse_Homo sapiens_hsa047280.88561898
76Biosynthesis of amino acids_Homo sapiens_hsa012300.88348789
77Melanoma_Homo sapiens_hsa052180.86726194
78DNA replication_Homo sapiens_hsa030300.86674816
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85601934
80Estrogen signaling pathway_Homo sapiens_hsa049150.83687414
81Base excision repair_Homo sapiens_hsa034100.81386961
82Cocaine addiction_Homo sapiens_hsa050300.78848162
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78784781
84Oxytocin signaling pathway_Homo sapiens_hsa049210.78223265
85Mismatch repair_Homo sapiens_hsa034300.77734693
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76620618
87RNA degradation_Homo sapiens_hsa030180.73171826
88Circadian entrainment_Homo sapiens_hsa047130.73051822
89Non-small cell lung cancer_Homo sapiens_hsa052230.72283921
90Lysine degradation_Homo sapiens_hsa003100.71995905
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70953719
92VEGF signaling pathway_Homo sapiens_hsa043700.70286152
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70219782
94AMPK signaling pathway_Homo sapiens_hsa041520.70198983
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69363108
96Vitamin digestion and absorption_Homo sapiens_hsa049770.68908914
97Glucagon signaling pathway_Homo sapiens_hsa049220.68729819
98Cholinergic synapse_Homo sapiens_hsa047250.68519175
99Basal transcription factors_Homo sapiens_hsa030220.68461559
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67888509
101Fanconi anemia pathway_Homo sapiens_hsa034600.67704064
102Linoleic acid metabolism_Homo sapiens_hsa005910.67620395
103ECM-receptor interaction_Homo sapiens_hsa045120.66984264
104Small cell lung cancer_Homo sapiens_hsa052220.66701711
105Prostate cancer_Homo sapiens_hsa052150.66633319
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66482939
107Tryptophan metabolism_Homo sapiens_hsa003800.66468334
108Nucleotide excision repair_Homo sapiens_hsa034200.66041034
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66005368
110Insulin signaling pathway_Homo sapiens_hsa049100.65452151
111Rap1 signaling pathway_Homo sapiens_hsa040150.65381835
112beta-Alanine metabolism_Homo sapiens_hsa004100.63203949
113Huntingtons disease_Homo sapiens_hsa050160.62970297
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62919893
115Pancreatic cancer_Homo sapiens_hsa052120.62541082
116Epstein-Barr virus infection_Homo sapiens_hsa051690.61823372
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61031743
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61016193
119Bladder cancer_Homo sapiens_hsa052190.60712072
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60050841
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60031521
122N-Glycan biosynthesis_Homo sapiens_hsa005100.59306978
123Viral carcinogenesis_Homo sapiens_hsa052030.58903948
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58697141
125p53 signaling pathway_Homo sapiens_hsa041150.57855009
126MAPK signaling pathway_Homo sapiens_hsa040100.57499557
127Butanoate metabolism_Homo sapiens_hsa006500.57130387
128HIF-1 signaling pathway_Homo sapiens_hsa040660.57066065
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56601936
130RNA polymerase_Homo sapiens_hsa030200.56105272
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55625548
132Ether lipid metabolism_Homo sapiens_hsa005650.55362811
133Systemic lupus erythematosus_Homo sapiens_hsa053220.54004890
134GnRH signaling pathway_Homo sapiens_hsa049120.53609115
135Long-term depression_Homo sapiens_hsa047300.53349283
136Metabolic pathways_Homo sapiens_hsa011000.53073993
137Proteasome_Homo sapiens_hsa030500.49873352
138Caffeine metabolism_Homo sapiens_hsa002320.49288443
139Long-term potentiation_Homo sapiens_hsa047200.48987939
140Endocytosis_Homo sapiens_hsa041440.48631157
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48606758
142Renin secretion_Homo sapiens_hsa049240.47110636
143Dorso-ventral axis formation_Homo sapiens_hsa043200.45895999
144Glutamatergic synapse_Homo sapiens_hsa047240.45770943
145Arginine and proline metabolism_Homo sapiens_hsa003300.45612756
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42503157
147Serotonergic synapse_Homo sapiens_hsa047260.42158499
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40768444
149Carbon metabolism_Homo sapiens_hsa012000.40765881
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38666584
151Folate biosynthesis_Homo sapiens_hsa007900.37639469
152Retinol metabolism_Homo sapiens_hsa008300.36592632
153Olfactory transduction_Homo sapiens_hsa047400.34219730
154Peroxisome_Homo sapiens_hsa041460.34129520
155Nitrogen metabolism_Homo sapiens_hsa009100.31370772
156GABAergic synapse_Homo sapiens_hsa047270.31262836
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31091509
158Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29392632
159Fatty acid elongation_Homo sapiens_hsa000620.29133745
160Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27819976
161Maturity onset diabetes of the young_Homo sapiens_hsa049500.24714447
162Glutathione metabolism_Homo sapiens_hsa004800.24004012

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