VAPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)4.97082361
2protein deneddylation (GO:0000338)4.81764733
3proteasome assembly (GO:0043248)4.37212808
4COPI coating of Golgi vesicle (GO:0048205)4.30976562
5Golgi transport vesicle coating (GO:0048200)4.30976562
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.28209699
7positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.22681192
8regulation of translational termination (GO:0006449)4.11981754
9DNA deamination (GO:0045006)4.08495564
10nucleobase-containing small molecule interconversion (GO:0015949)4.07425172
11regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.06368398
12purine nucleobase biosynthetic process (GO:0009113)4.05471165
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.02549536
14regulation of cellular amino acid metabolic process (GO:0006521)3.98886720
15ribosome assembly (GO:0042255)3.96854560
16anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.93343972
17protein maturation by protein folding (GO:0022417)3.93114101
18antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.91754253
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.84673737
20positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.83451462
21negative regulation of ligase activity (GO:0051352)3.82250347
22negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.82250347
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.81511406
24de novo protein folding (GO:0006458)3.81281445
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.73691307
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.73691307
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.72334973
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.72334973
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.72334973
30positive regulation of ligase activity (GO:0051351)3.71046790
31signal peptide processing (GO:0006465)3.64515828
32regulation of mitochondrial translation (GO:0070129)3.61808119
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.61771654
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.61771654
352-deoxyribonucleotide biosynthetic process (GO:0009265)3.59611284
36deoxyribose phosphate biosynthetic process (GO:0046385)3.59611284
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.54523805
38positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.53102440
39de novo posttranslational protein folding (GO:0051084)3.52706386
40protein refolding (GO:0042026)3.52360673
41formation of translation preinitiation complex (GO:0001731)3.47704670
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.46923434
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44141880
44membrane budding (GO:0006900)3.43054467
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.42106806
46sequestering of actin monomers (GO:0042989)3.41321178
47ribonucleoprotein complex disassembly (GO:0032988)3.39369995
48antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.35512837
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32610702
50nucleobase biosynthetic process (GO:0046112)3.32048220
51mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.28767032
52succinate metabolic process (GO:0006105)3.26659692
53regulation of ubiquitin-protein transferase activity (GO:0051438)3.24646310
54protein retention in ER lumen (GO:0006621)3.23427276
55ribosome biogenesis (GO:0042254)3.22896113
56protein neddylation (GO:0045116)3.19240809
577-methylguanosine RNA capping (GO:0009452)3.18979979
58RNA capping (GO:0036260)3.18979979
59platelet dense granule organization (GO:0060155)3.18913356
60establishment of protein localization to mitochondrion (GO:0072655)3.17658361
61regulation of ligase activity (GO:0051340)3.16887869
62magnesium ion transport (GO:0015693)3.15483209
63guanosine-containing compound biosynthetic process (GO:1901070)3.13560608
64protein localization to mitochondrion (GO:0070585)3.12463152
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.11617263
66regulation of protein heterodimerization activity (GO:0043497)3.11600050
677-methylguanosine mRNA capping (GO:0006370)3.10978535
68protein import into peroxisome matrix (GO:0016558)3.10318033
69regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.08568166
70positive regulation of cell cycle arrest (GO:0071158)3.07102967
71establishment of protein localization to mitochondrial membrane (GO:0090151)3.06957743
72deoxyribonucleotide biosynthetic process (GO:0009263)3.05062209
73protein targeting to mitochondrion (GO:0006626)3.04865026
74positive regulation of mitochondrial fission (GO:0090141)3.04681359
75chaperone-mediated protein folding (GO:0061077)3.03715030
76gamma-aminobutyric acid transport (GO:0015812)3.01467530
77G1/S transition of mitotic cell cycle (GO:0000082)3.01188515
78cell cycle G1/S phase transition (GO:0044843)3.01188515
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01121243
80GPI anchor metabolic process (GO:0006505)2.99915052
81protein targeting to peroxisome (GO:0006625)2.99658156
82establishment of protein localization to peroxisome (GO:0072663)2.99658156
83protein localization to peroxisome (GO:0072662)2.99658156
84transcription elongation from RNA polymerase III promoter (GO:0006385)2.96698397
85termination of RNA polymerase III transcription (GO:0006386)2.96698397
86one-carbon compound transport (GO:0019755)2.95719522
87nucleotide transmembrane transport (GO:1901679)2.94045079
88regulation of cellular amine metabolic process (GO:0033238)2.93958580
89mitochondrial calcium ion homeostasis (GO:0051560)2.91783811
90folic acid transport (GO:0015884)2.91253185
91positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.91059687
92reactive oxygen species biosynthetic process (GO:1903409)2.88239580
93peroxisome organization (GO:0007031)2.87891311
94mitochondrial calcium ion transport (GO:0006851)2.87451201
95protein complex biogenesis (GO:0070271)2.86150709
96deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.84970339
97viral mRNA export from host cell nucleus (GO:0046784)2.84428222
98ATP synthesis coupled proton transport (GO:0015986)2.83343967
99energy coupled proton transport, down electrochemical gradient (GO:0015985)2.83343967
100preassembly of GPI anchor in ER membrane (GO:0016254)2.83300931
101regulation of early endosome to late endosome transport (GO:2000641)2.83126917
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82021387
103mitochondrial respiratory chain complex I assembly (GO:0032981)2.81794766
104NADH dehydrogenase complex assembly (GO:0010257)2.81794766
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81794766
106synaptic vesicle maturation (GO:0016188)2.81677999
107actin nucleation (GO:0045010)2.81474903
108GPI anchor biosynthetic process (GO:0006506)2.77306118
109negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.77228870
110organelle disassembly (GO:1903008)2.76804118
111ADP metabolic process (GO:0046031)2.75571171
112peroxisome fission (GO:0016559)2.75299383
113antigen processing and presentation of exogenous peptide antigen (GO:0002478)2.72965208
114anterograde synaptic vesicle transport (GO:0048490)2.72752995
115misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.72726731
116oxidative phosphorylation (GO:0006119)2.70930761
117positive regulation of actin filament depolymerization (GO:0030836)2.70346953
118antigen processing and presentation of exogenous antigen (GO:0019884)2.68628676
119transferrin transport (GO:0033572)2.67036258
120L-methionine salvage (GO:0071267)2.66862081
121L-methionine biosynthetic process (GO:0071265)2.66862081
122amino acid salvage (GO:0043102)2.66862081
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66400525
124IMP metabolic process (GO:0046040)2.65776876
125righting reflex (GO:0060013)2.64384768
126hydrogen peroxide biosynthetic process (GO:0050665)2.64202228
127protein K11-linked ubiquitination (GO:0070979)2.63212369
128regulation of histone phosphorylation (GO:0033127)2.62783822
129GDP-mannose metabolic process (GO:0019673)2.62120160
130mitochondrial respiratory chain complex assembly (GO:0033108)2.62056826
131cellular ketone body metabolic process (GO:0046950)2.61795487
132negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.61559060
133ubiquinone biosynthetic process (GO:0006744)2.61512694
134response to misfolded protein (GO:0051788)2.60699994
135nucleoside diphosphate biosynthetic process (GO:0009133)2.60146358
136positive regulation of protein ubiquitination (GO:0031398)2.59830250
137DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.59031013
138ATP hydrolysis coupled proton transport (GO:0015991)2.58982723
139energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.58982723
140lipopolysaccharide biosynthetic process (GO:0009103)2.58489282
141glycolipid biosynthetic process (GO:0009247)2.56124906
142C-terminal protein lipidation (GO:0006501)2.53963955
143glycosphingolipid biosynthetic process (GO:0006688)2.52395175
144pyrimidine dimer repair (GO:0006290)2.52084001
145regulation of cilium movement (GO:0003352)2.51615798
146ubiquinone metabolic process (GO:0006743)2.50570567
147glycerol ether metabolic process (GO:0006662)2.49957976
148branched-chain amino acid catabolic process (GO:0009083)2.47691362
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.46749605
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.46749605
151positive regulation of TOR signaling (GO:0032008)2.46305270
152regulation of mitochondrial fission (GO:0090140)2.46023857
153regulation of cell communication by electrical coupling (GO:0010649)2.45508314
154C-terminal protein amino acid modification (GO:0018410)2.44534699
155ether metabolic process (GO:0018904)2.44501590
156peroxisomal transport (GO:0043574)2.43935798
157diterpenoid biosynthetic process (GO:0016102)2.43422800
158positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.42194388
159synaptic vesicle exocytosis (GO:0016079)2.39679079
160negative regulation of acute inflammatory response (GO:0002674)2.37422672
161positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.36476968
162water-soluble vitamin biosynthetic process (GO:0042364)2.33760218
163protein-cofactor linkage (GO:0018065)2.33438919
164anterograde axon cargo transport (GO:0008089)2.33118475
165negative regulation of heart rate (GO:0010459)2.31581484
166regulation of protein glycosylation (GO:0060049)2.29357453
167ketone body metabolic process (GO:1902224)2.29292586
168positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.28041233
169mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.28041233
170respiratory chain complex IV assembly (GO:0008535)2.26423450
171GMP metabolic process (GO:0046037)2.26368655
172RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.25764757
173isoprenoid biosynthetic process (GO:0008299)2.25549940
174keratinocyte development (GO:0003334)2.25270905
175adenosine metabolic process (GO:0046085)2.24822211
176nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.23258458
177detection of calcium ion (GO:0005513)2.22976301
178axoneme assembly (GO:0035082)2.22972760
179quinone metabolic process (GO:1901661)2.21007013
180negative regulation of mast cell activation (GO:0033004)2.20275570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.16097008
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99295534
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.95817052
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81935003
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.68466605
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52705358
7POU3F2_20337985_ChIP-ChIP_501MEL_Human3.44415782
8IGF1R_20145208_ChIP-Seq_DFB_Human3.05810751
9* EST1_17652178_ChIP-ChIP_JURKAT_Human3.02627293
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.00306449
11E2F7_22180533_ChIP-Seq_HELA_Human2.97449237
12GBX2_23144817_ChIP-Seq_PC3_Human2.92153178
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.90982303
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87552472
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.81750416
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80696099
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75804706
18DCP1A_22483619_ChIP-Seq_HELA_Human2.71707053
19TAF15_26573619_Chip-Seq_HEK293_Human2.62815829
20VDR_22108803_ChIP-Seq_LS180_Human2.61774123
21* VDR_23849224_ChIP-Seq_CD4+_Human2.60843423
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.59487729
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57956699
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57328541
25ELK1_19687146_ChIP-ChIP_HELA_Human2.56206790
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53601054
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.51657307
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36545812
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31966866
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29315488
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25868977
32* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.25722391
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.23068355
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22790897
35ZNF274_21170338_ChIP-Seq_K562_Hela2.21362784
36XRN2_22483619_ChIP-Seq_HELA_Human2.20324882
37GABP_19822575_ChIP-Seq_HepG2_Human2.19774655
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17428890
39FUS_26573619_Chip-Seq_HEK293_Human2.15929562
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.14959207
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99474137
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95900763
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95188803
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94596036
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91395141
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.87673128
47EWS_26573619_Chip-Seq_HEK293_Human1.85755088
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85595031
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80754577
50P300_19829295_ChIP-Seq_ESCs_Human1.78720670
51TTF2_22483619_ChIP-Seq_HELA_Human1.77907760
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.76616461
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74405602
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71862783
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69710135
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68658159
57AR_21909140_ChIP-Seq_LNCAP_Human1.67048804
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.64688426
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64052501
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63906256
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.63128827
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62758382
63ER_23166858_ChIP-Seq_MCF-7_Human1.62592501
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.61724734
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60060574
66TFEB_21752829_ChIP-Seq_HELA_Human1.58873259
67* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58549766
68SMAD4_21799915_ChIP-Seq_A2780_Human1.57453156
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57144958
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56852480
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55993986
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55275881
73CBP_20019798_ChIP-Seq_JUKART_Human1.55275881
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.53905215
75FOXP3_21729870_ChIP-Seq_TREG_Human1.52220734
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51336032
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49366751
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48300755
79TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.46377982
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45361608
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45058199
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44170796
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43443206
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40507952
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38135369
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37642389
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.37176342
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36663495
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36663495
90IRF1_19129219_ChIP-ChIP_H3396_Human1.36362699
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36065913
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34262244
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33218995
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33124635
95TP53_22573176_ChIP-Seq_HFKS_Human1.31667516
96* JUN_21703547_ChIP-Seq_K562_Human1.31512428
97HTT_18923047_ChIP-ChIP_STHdh_Human1.30750562
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.30647858
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28512755
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28399919
101* NANOG_19829295_ChIP-Seq_ESCs_Human1.28099111
102* SOX2_19829295_ChIP-Seq_ESCs_Human1.28099111
103* STAT3_23295773_ChIP-Seq_U87_Human1.27924000
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27920031
105CLOCK_20551151_ChIP-Seq_293T_Human1.27713763
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26272391
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26267323
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25984708
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25977975
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25566208
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25314452
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25201074
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24807312
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24314744
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24172014
116AR_25329375_ChIP-Seq_VCAP_Human1.23646529
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.22932288
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.21789695
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21574257
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.20325103
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19655677
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19059202
123P53_22387025_ChIP-Seq_ESCs_Mouse1.17900178
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17764170
125MYC_18940864_ChIP-ChIP_HL60_Human1.17164198
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17062302
127FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15813676
128FOXA1_25329375_ChIP-Seq_VCAP_Human1.15813676
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15554534
130E2F1_21310950_ChIP-Seq_MCF-7_Human1.15057750
131* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.14926465
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13035060
133* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12105897
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11933374
135CDX2_22108803_ChIP-Seq_LS180_Human1.11893085
136KDM5A_27292631_Chip-Seq_BREAST_Human1.10883206
137SALL4_22934838_ChIP-ChIP_CD34+_Human1.10782670
138MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10643750
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10465065
140SMAD_19615063_ChIP-ChIP_OVARY_Human1.09787693
141CRX_20693478_ChIP-Seq_RETINA_Mouse1.09707083
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09128425
143NFE2_27457419_Chip-Seq_LIVER_Mouse1.08712895
144STAT3_18555785_Chip-Seq_ESCs_Mouse1.08233444
145SOX17_20123909_ChIP-Seq_XEN_Mouse1.07592005
146FLI1_21867929_ChIP-Seq_TH2_Mouse1.07244362
147* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07057631
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06896176
149ZNF263_19887448_ChIP-Seq_K562_Human1.06444398
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06031525
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05731401
152E2F1_18555785_Chip-Seq_ESCs_Mouse1.05579676
153SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05219196
154CMYC_18555785_Chip-Seq_ESCs_Mouse1.04531095
155ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04441922
156SOX2_18555785_Chip-Seq_ESCs_Mouse1.04323910
157TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03940288
158* TCF4_23295773_ChIP-Seq_U87_Human1.03894547
159P300_18555785_Chip-Seq_ESCs_Mouse1.03613933
160SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03565348
161POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03448551
162* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02626244
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02599199
164REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01264845
165EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01006148
166* TCF4_22108803_ChIP-Seq_LS180_Human1.00125877
167RNF2_27304074_Chip-Seq_NSC_Mouse0.99644385
168* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96774339
169FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96079430
170NANOG_16153702_ChIP-ChIP_HESCs_Human0.91698427
171NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89196058
172CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89109507
173SPI1_23547873_ChIP-Seq_NB4_Human0.88812044
174TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88558161
175OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88100459
176HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85435791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.33241835
2MP0004957_abnormal_blastocyst_morpholog3.60156620
3MP0004147_increased_porphyrin_level3.38865067
4MP0003123_paternal_imprinting3.23703441
5MP0000013_abnormal_adipose_tissue3.08611186
6MP0006054_spinal_hemorrhage2.90004458
7MP0009046_muscle_twitch2.82526183
8MP0002837_dystrophic_cardiac_calcinosis2.69610045
9MP0002877_abnormal_melanocyte_morpholog2.68872514
10MP0005646_abnormal_pituitary_gland2.66421133
11MP0003186_abnormal_redox_activity2.66098691
12MP0008007_abnormal_cellular_replicative2.65290343
13MP0003786_premature_aging2.58277539
14MP0001542_abnormal_bone_strength2.57949058
15MP0002102_abnormal_ear_morphology2.53691636
16MP0003195_calcinosis2.52673335
17MP0004270_analgesia2.46412028
18MP0009780_abnormal_chondrocyte_physiolo2.33785200
19MP0003806_abnormal_nucleotide_metabolis2.31057382
20MP0008932_abnormal_embryonic_tissue2.26166076
21MP0001968_abnormal_touch/_nociception2.15217596
22MP0003656_abnormal_erythrocyte_physiolo2.10597452
23MP0004782_abnormal_surfactant_physiolog1.98488092
24MP0010234_abnormal_vibrissa_follicle1.95230586
25MP0009697_abnormal_copulation1.94598630
26MP0002736_abnormal_nociception_after1.84115293
27MP0002272_abnormal_nervous_system1.82394442
28MP0003077_abnormal_cell_cycle1.81626117
29MP0008875_abnormal_xenobiotic_pharmacok1.80016575
30MP0005084_abnormal_gallbladder_morpholo1.77649630
31MP0003880_abnormal_central_pattern1.76690817
32MP0001188_hyperpigmentation1.73508857
33MP0004859_abnormal_synaptic_plasticity1.72546086
34MP0002160_abnormal_reproductive_system1.72282063
35MP0003221_abnormal_cardiomyocyte_apopto1.72056590
36MP0002876_abnormal_thyroid_physiology1.68170117
37MP0008260_abnormal_autophagy1.67857721
38MP0009745_abnormal_behavioral_response1.66557231
39MP0002822_catalepsy1.66390753
40MP0004215_abnormal_myocardial_fiber1.63406193
41MP0003183_abnormal_peptide_metabolism1.62786757
42MP0000358_abnormal_cell_content/1.61353726
43MP0008877_abnormal_DNA_methylation1.60048692
44MP0001730_embryonic_growth_arrest1.58369585
45MP0003718_maternal_effect1.57067664
46MP0004142_abnormal_muscle_tone1.56399016
47MP0002638_abnormal_pupillary_reflex1.55238705
48MP0002751_abnormal_autonomic_nervous1.54980740
49MP0005058_abnormal_lysosome_morphology1.53995146
50MP0000516_abnormal_urinary_system1.52609278
51MP0005367_renal/urinary_system_phenotyp1.52609278
52MP0010352_gastrointestinal_tract_polyps1.50749255
53MP0001501_abnormal_sleep_pattern1.50338191
54MP0002090_abnormal_vision1.45840518
55MP0006072_abnormal_retinal_apoptosis1.43549033
56MP0008872_abnormal_physiological_respon1.43147489
57MP0004145_abnormal_muscle_electrophysio1.43025398
58MP0001529_abnormal_vocalization1.43008105
59MP0004043_abnormal_pH_regulation1.41426298
60MP0004924_abnormal_behavior1.37065760
61MP0005386_behavior/neurological_phenoty1.37065760
62MP0001984_abnormal_olfaction1.36904331
63MP0005389_reproductive_system_phenotype1.35827230
64MP0003635_abnormal_synaptic_transmissio1.35691046
65MP0001486_abnormal_startle_reflex1.31706794
66MP0004858_abnormal_nervous_system1.31617017
67MP0003111_abnormal_nucleus_morphology1.30039290
68MP0001502_abnormal_circadian_rhythm1.29864002
69MP0005636_abnormal_mineral_homeostasis1.29474273
70MP0000343_altered_response_to1.28747611
71MP0010307_abnormal_tumor_latency1.28584684
72MP0010094_abnormal_chromosome_stability1.28521427
73MP0002064_seizures1.28009718
74MP0000350_abnormal_cell_proliferation1.27536327
75MP0006276_abnormal_autonomic_nervous1.23529792
76MP0001986_abnormal_taste_sensitivity1.21647763
77MP0002735_abnormal_chemical_nociception1.21578627
78MP0000639_abnormal_adrenal_gland1.20136034
79MP0001919_abnormal_reproductive_system1.18563734
80MP0005253_abnormal_eye_physiology1.18149089
81MP0005332_abnormal_amino_acid1.15683668
82MP0005408_hypopigmentation1.14235203
83MP0006036_abnormal_mitochondrial_physio1.13596193
84MP0002734_abnormal_mechanical_nocicepti1.13222837
85MP0004484_altered_response_of1.12500220
86MP0008995_early_reproductive_senescence1.11798619
87MP0009333_abnormal_splenocyte_physiolog1.11452095
88MP0000750_abnormal_muscle_regeneration1.11432840
89MP0005551_abnormal_eye_electrophysiolog1.11313020
90MP0008058_abnormal_DNA_repair1.10466029
91MP0003329_amyloid_beta_deposits1.10302036
92MP0003315_abnormal_perineum_morphology1.08900658
93MP0008775_abnormal_heart_ventricle1.08769083
94MP0002572_abnormal_emotion/affect_behav1.07853832
95MP0000465_gastrointestinal_hemorrhage1.07792810
96MP0001764_abnormal_homeostasis1.06534672
97MP0004085_abnormal_heartbeat1.06094112
98MP0010386_abnormal_urinary_bladder1.04657478
99MP0002557_abnormal_social/conspecific_i1.03673105
100MP0001727_abnormal_embryo_implantation1.03524524
101MP0001958_emphysema1.01558076
102MP0003567_abnormal_fetal_cardiomyocyte1.00495463
103MP0003633_abnormal_nervous_system1.00088970
104MP0001697_abnormal_embryo_size0.99806850
105MP0003950_abnormal_plasma_membrane0.99473416
106MP0000372_irregular_coat_pigmentation0.98677872
107MP0000427_abnormal_hair_cycle0.98151727
108MP0006035_abnormal_mitochondrial_morpho0.97231646
109MP0001661_extended_life_span0.96815288
110MP0002229_neurodegeneration0.96811234
111MP0000858_altered_metastatic_potential0.96722816
112MP0008438_abnormal_cutaneous_collagen0.95704140
113MP0002063_abnormal_learning/memory/cond0.95400548
114MP0005535_abnormal_body_temperature0.93731018
115MP0002067_abnormal_sensory_capabilities0.93696331
116MP0002909_abnormal_adrenal_gland0.92314261
117MP0001145_abnormal_male_reproductive0.91154473
118MP0002080_prenatal_lethality0.90919588
119MP0002009_preneoplasia0.90894557
120MP0002148_abnormal_hypersensitivity_rea0.90755355
121MP0002210_abnormal_sex_determination0.90258512
122MP0001177_atelectasis0.89969227
123MP0004885_abnormal_endolymph0.89845715
124MP0003121_genomic_imprinting0.87764930
125MP0009765_abnormal_xenobiotic_induced0.86801478
126MP0005384_cellular_phenotype0.86763124
127MP0005164_abnormal_response_to0.86006812
128MP0010678_abnormal_skin_adnexa0.84584868
129MP0002733_abnormal_thermal_nociception0.84411318
130MP0009764_decreased_sensitivity_to0.83311893
131MP0003787_abnormal_imprinting0.82200899
132MP0008004_abnormal_stomach_pH0.81993509
133MP0000681_abnormal_thyroid_gland0.79949238
134MP0000313_abnormal_cell_death0.78944208
135MP0004883_abnormal_blood_vessel0.78493334
136MP0003646_muscle_fatigue0.78381831
137MP0001765_abnormal_ion_homeostasis0.76820391
138MP0003122_maternal_imprinting0.76387001
139MP0002938_white_spotting0.76308970
140MP0003878_abnormal_ear_physiology0.75043170
141MP0005377_hearing/vestibular/ear_phenot0.75043170
142MP0000631_abnormal_neuroendocrine_gland0.74957021
143MP0003436_decreased_susceptibility_to0.74487392
144MP0000537_abnormal_urethra_morphology0.74162463
145MP0005621_abnormal_cell_physiology0.73029123
146MP0001485_abnormal_pinna_reflex0.72641947
147MP0005397_hematopoietic_system_phenotyp0.71232096
148MP0001545_abnormal_hematopoietic_system0.71232096
149MP0005266_abnormal_metabolism0.69659285
150MP0005645_abnormal_hypothalamus_physiol0.66949750
151MP0000653_abnormal_sex_gland0.65641337
152MP0000604_amyloidosis0.64291668
153MP0000747_muscle_weakness0.63613365
154MP0001905_abnormal_dopamine_level0.63388673
155MP0005076_abnormal_cell_differentiation0.62919937
156MP0004084_abnormal_cardiac_muscle0.62615782
157MP0001970_abnormal_pain_threshold0.61579630
158MP0001533_abnormal_skeleton_physiology0.60104747
159MP0005376_homeostasis/metabolism_phenot0.59595778
160MP0001929_abnormal_gametogenesis0.59361083
161MP0001756_abnormal_urination0.58613264
162MP0005220_abnormal_exocrine_pancreas0.58560570
163MP0002084_abnormal_developmental_patter0.58396549
164MP0003795_abnormal_bone_structure0.58349766

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)4.47323327
2Degeneration of anterior horn cells (HP:0002398)4.47323327
3Shoulder girdle muscle weakness (HP:0003547)3.89569081
4Abnormality of alanine metabolism (HP:0010916)3.68797673
5Hyperalaninemia (HP:0003348)3.68797673
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.68797673
7Pelvic girdle muscle weakness (HP:0003749)3.50547441
8Tongue fasciculations (HP:0001308)3.49915817
9Atrophy/Degeneration involving motor neurons (HP:0007373)3.36154284
10Abnormality of the musculature of the pelvis (HP:0001469)3.36102618
11Abnormality of the hip-girdle musculature (HP:0001445)3.36102618
12Dysautonomia (HP:0002459)3.11762931
13Methylmalonic acidemia (HP:0002912)3.04038267
14Muscle fibrillation (HP:0010546)2.94318028
15Poor head control (HP:0002421)2.93956079
16Neoplasm of the adrenal gland (HP:0100631)2.93159094
17Acute necrotizing encephalopathy (HP:0006965)2.91823267
18Abnormal mitochondria in muscle tissue (HP:0008316)2.84786849
19Birth length less than 3rd percentile (HP:0003561)2.79314305
20Ketoacidosis (HP:0001993)2.77083877
2111 pairs of ribs (HP:0000878)2.73856276
22Cerebral hypomyelination (HP:0006808)2.71003506
23Neuroendocrine neoplasm (HP:0100634)2.70219569
24Postnatal microcephaly (HP:0005484)2.69003864
25Mitochondrial inheritance (HP:0001427)2.68685713
26Carpal bone hypoplasia (HP:0001498)2.66097335
27Methylmalonic aciduria (HP:0012120)2.63264273
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62872080
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62872080
30Thyroid-stimulating hormone excess (HP:0002925)2.62369434
31Type I transferrin isoform profile (HP:0003642)2.57587142
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49078446
33Abnormal protein N-linked glycosylation (HP:0012347)2.49078446
34Abnormal protein glycosylation (HP:0012346)2.49078446
35Abnormal glycosylation (HP:0012345)2.49078446
36Personality changes (HP:0000751)2.48628487
37Increased CSF lactate (HP:0002490)2.48524530
38Medial flaring of the eyebrow (HP:0010747)2.47776958
39Irregular epiphyses (HP:0010582)2.47405308
40Polyphagia (HP:0002591)2.46465949
41Brushfield spots (HP:0001088)2.46191784
423-Methylglutaconic aciduria (HP:0003535)2.45811978
43Pheochromocytoma (HP:0002666)2.45059784
44Rough bone trabeculation (HP:0100670)2.44183090
45Patent foramen ovale (HP:0001655)2.41474748
46Secondary amenorrhea (HP:0000869)2.40270812
47Testicular neoplasm (HP:0010788)2.39599898
48Abnormality of glycolysis (HP:0004366)2.37672418
49Increased serum pyruvate (HP:0003542)2.37672418
50Unsteady gait (HP:0002317)2.37376926
51Short tibia (HP:0005736)2.37207575
52Progressive macrocephaly (HP:0004481)2.37113595
53Hypoglycemic coma (HP:0001325)2.36747718
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.35169836
55Cerebral edema (HP:0002181)2.34352376
56Gonadal dysgenesis (HP:0000133)2.34269224
57Microretrognathia (HP:0000308)2.33688521
58Vertebral compression fractures (HP:0002953)2.32616079
59Renal cortical cysts (HP:0000803)2.30011234
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.25333573
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.25333573
62Palpitations (HP:0001962)2.24912586
63Aplastic anemia (HP:0001915)2.24204657
64Diminished motivation (HP:0000745)2.23898106
65Increased hepatocellular lipid droplets (HP:0006565)2.22948437
66Lipid accumulation in hepatocytes (HP:0006561)2.22765551
67Delayed gross motor development (HP:0002194)2.20888137
68Gait imbalance (HP:0002141)2.20308359
69Abnormal autonomic nervous system physiology (HP:0012332)2.17869969
70Febrile seizures (HP:0002373)2.16814777
71Hepatocellular necrosis (HP:0001404)2.15165470
72Congenital primary aphakia (HP:0007707)2.13807796
73Insulin-resistant diabetes mellitus (HP:0000831)2.13683355
74Nephrogenic diabetes insipidus (HP:0009806)2.13511285
75Delusions (HP:0000746)2.12691560
76Abnormality of vitamin B metabolism (HP:0004340)2.11383527
77Agnosia (HP:0010524)2.10594584
78Increased intramyocellular lipid droplets (HP:0012240)2.09451478
79Thyroid carcinoma (HP:0002890)2.09443820
80Progressive neurologic deterioration (HP:0002344)2.09065058
81Heterochromia iridis (HP:0001100)2.08505694
82Nemaline bodies (HP:0003798)2.07039361
83Abnormality of the umbilical cord (HP:0010881)2.06718572
84Poor suck (HP:0002033)2.06495822
85Abnormality of the distal phalanges of the toes (HP:0010182)2.05691419
86Oral leukoplakia (HP:0002745)2.05516128
87Acute encephalopathy (HP:0006846)2.05260231
88Increased serum lactate (HP:0002151)2.02535177
89Hyperinsulinemic hypoglycemia (HP:0000825)2.01699668
90Hepatic necrosis (HP:0002605)2.01186036
91Pancreatic islet-cell hyperplasia (HP:0004510)2.01026363
92Sensorimotor neuropathy (HP:0007141)2.00450674
93Breast hypoplasia (HP:0003187)2.00425946
94Slender long bone (HP:0003100)2.00307963
95True hermaphroditism (HP:0010459)1.99789010
96Hyperthyroidism (HP:0000836)1.99597795
97Progressive microcephaly (HP:0000253)1.99416769
98Menstrual irregularities (HP:0000858)1.96616048
99Short nail (HP:0001799)1.95475085
100Pancreatic cysts (HP:0001737)1.95299923
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94886454
102Lethargy (HP:0001254)1.94161634
103Abnormal neuron morphology (HP:0012757)1.93962950
104Abnormality of the motor neurons (HP:0002450)1.93962950
105Abnormality of glycolipid metabolism (HP:0010969)1.93725487
106Abnormality of liposaccharide metabolism (HP:0010968)1.93725487
107Abnormality of glycosphingolipid metabolism (HP:0004343)1.93725487
108Ketosis (HP:0001946)1.93615528
109Focal motor seizures (HP:0011153)1.92826986
110Lactic acidosis (HP:0003128)1.92551711
111Fasciculations (HP:0002380)1.92437993
112Abnormality of macrophages (HP:0004311)1.91854956
113Metaphyseal dysplasia (HP:0100255)1.91593427
114Amyotrophic lateral sclerosis (HP:0007354)1.91301879
115Aplasia/hypoplasia of the uterus (HP:0008684)1.90798194
116Hyperammonemia (HP:0001987)1.90791825
117Abnormality of the vitamin B12 metabolism (HP:0004341)1.90739303
118Papillary thyroid carcinoma (HP:0002895)1.90636148
119Atonic seizures (HP:0010819)1.89921529
120Cutaneous melanoma (HP:0012056)1.89812047
121Gaze-evoked nystagmus (HP:0000640)1.89793137
122Glossoptosis (HP:0000162)1.89296787
123Large for gestational age (HP:0001520)1.89143675
124Hypoplasia of the uterus (HP:0000013)1.87981903
125Vacuolated lymphocytes (HP:0001922)1.87931039
126Apathy (HP:0000741)1.87251832
127Neoplasm of the peripheral nervous system (HP:0100007)1.86963214
128Respiratory failure (HP:0002878)1.86893792
129Distal arthrogryposis (HP:0005684)1.86774933
130Pancreatic fibrosis (HP:0100732)1.85523624
131Autoamputation (HP:0001218)1.85096888
132Muscular hypotonia of the trunk (HP:0008936)1.84827772
133Abnormality of the heme biosynthetic pathway (HP:0010472)1.83624793
134Increased neuronal autofluorescent lipopigment (HP:0002074)1.82531421
135Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82495719
136Hypothermia (HP:0002045)1.82039276
137CNS demyelination (HP:0007305)1.81828796
138Epiphyseal stippling (HP:0010655)1.81567740
139Abolished electroretinogram (ERG) (HP:0000550)1.80379252
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78492222
141Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78480214
142Emotional lability (HP:0000712)1.78361853
143Increased muscle lipid content (HP:0009058)1.78235781
144Gonadotropin excess (HP:0000837)1.78101265
145CNS hypomyelination (HP:0003429)1.77825026
146Abnormal respiratory epithelium morphology (HP:0012253)1.77718852
147Abnormal respiratory motile cilium morphology (HP:0005938)1.77718852
148Difficulty climbing stairs (HP:0003551)1.77687407
149Hemiparesis (HP:0001269)1.77568150
150Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77333785
151Missing ribs (HP:0000921)1.76528925
152Type 2 muscle fiber atrophy (HP:0003554)1.76086560
153Exercise intolerance (HP:0003546)1.75644144
154Myoglobinuria (HP:0002913)1.75426624
155Akinesia (HP:0002304)1.74985591
156Abnormality of the renal cortex (HP:0011035)1.73151873
157Dicarboxylic aciduria (HP:0003215)1.72952258
158Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72952258
159Epileptic encephalopathy (HP:0200134)1.72581775
160Hyperventilation (HP:0002883)1.71804838
161Hypoglycemic seizures (HP:0002173)1.71380572
162Hyperglycemia (HP:0003074)1.68926920
163Cerebral hemorrhage (HP:0001342)1.68816621
164Adrenal hypoplasia (HP:0000835)1.67244265
165Upper limb muscle weakness (HP:0003484)1.63856668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.35954012
2STK163.27070839
3BUB13.26270585
4LIMK13.15934491
5SCYL23.09049676
6MAP3K122.75093351
7TRIM282.70276751
8ARAF2.65893856
9EIF2AK32.62446487
10TESK12.60472216
11NEK12.48869438
12BCKDK2.40920031
13EIF2AK12.29911492
14ERBB32.14505915
15MAP2K72.10735186
16TESK22.08440032
17MAP3K42.02575218
18ACVR1B1.98757259
19CSNK1A1L1.95898903
20PBK1.94285739
21CSNK1G21.87589288
22BRSK21.87082711
23PIM21.86006399
24TSSK61.85278752
25MAP4K21.84524258
26SIK31.82494354
27WNK31.77012913
28BCR1.76660337
29EPHA31.67366110
30KSR11.60334079
31CSNK1G11.59252656
32ADRBK21.55815499
33EPHA21.54283471
34BRAF1.52131633
35CCNB11.51885765
36MAPK131.51444233
37MAP3K111.41962076
38CAMKK21.39420522
39MINK11.39026351
40NME11.34134403
41INSRR1.33290192
42MAPKAPK31.33128638
43RIPK41.24079353
44PLK31.23827350
45PLK21.23759460
46MUSK1.19232742
47RAF11.15225532
48DYRK31.14870576
49ZAK1.14294921
50KSR21.13833973
51MKNK11.11695861
52OXSR11.07222718
53GRK11.06716940
54PRKCE1.06664624
55MKNK21.06455508
56AURKA1.04566125
57PDK21.03930740
58BRSK11.02751204
59NME20.93978607
60PHKG10.93615616
61PHKG20.93615616
62NTRK30.88611039
63VRK10.87471214
64PAK40.86862369
65PLK40.85392264
66PAK30.85386817
67STK38L0.85035955
68RPS6KA40.84943652
69NEK90.84431365
70PAK60.84335899
71MST40.84313579
72RPS6KB20.84063549
73AKT30.82761360
74MAP2K10.82614043
75STK240.81951328
76FLT30.81160573
77CDC70.81101688
78CDK190.80362036
79DYRK20.79740521
80PINK10.79677128
81EIF2AK20.78622686
82STK390.77971105
83BMPR20.76583062
84NTRK10.72726447
85NUAK10.72331381
86PLK10.70633253
87FRK0.70531458
88ABL20.69534150
89MOS0.69508828
90DAPK10.69050890
91CAMK2A0.68944654
92CDK140.66953442
93CDK80.66781478
94MAP2K40.66582698
95BMPR1B0.65270432
96SRPK10.64642047
97PRKG20.59006217
98MAP3K20.58943057
99PRKCI0.58069065
100CAMK2D0.56258388
101STK30.56010290
102TAOK30.55998889
103MAP3K90.55651330
104CAMK2B0.54849322
105CAMK2G0.54731604
106PASK0.54497391
107NEK20.53715455
108TLK10.53333145
109RPS6KA50.53130037
110MAP3K60.53087767
111FER0.52796996
112MAP3K30.51685205
113MARK30.50969721
114CASK0.50146825
115BLK0.50001031
116CLK10.49736459
117PDK30.48646629
118PDK40.48646629
119PRKCG0.47395186
120CDK180.45750999
121TRPM70.45730648
122PAK10.45634185
123LATS20.43139986
124ERBB40.42649314
125YES10.41009380
126WNK40.40765781
127CSNK1G30.40759143
128TEC0.39308874
129MAP3K50.39104703
130MAP2K20.38206613
131PNCK0.38186800
132MARK10.38137428
133OBSCN0.37254035
134CSNK1A10.37120938
135MAP3K140.35558662
136ADRBK10.34852882
137KDR0.34529862
138UHMK10.34182889
139MYLK0.34146569
140CSNK2A10.34106432
141DAPK20.33899368
142AURKB0.33575651
143ILK0.33047701
144MAPKAPK50.32442946
145ABL10.32296025
146PIM10.32083654
147PRKACB0.30375966

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.39022969
2Protein export_Homo sapiens_hsa030603.39476873
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98627656
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.83740516
5RNA polymerase_Homo sapiens_hsa030202.70821247
6Oxidative phosphorylation_Homo sapiens_hsa001902.53749526
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.53395377
8Vibrio cholerae infection_Homo sapiens_hsa051102.46827918
9DNA replication_Homo sapiens_hsa030302.19511564
10RNA transport_Homo sapiens_hsa030132.13452558
11Parkinsons disease_Homo sapiens_hsa050122.13361974
12Nicotine addiction_Homo sapiens_hsa050332.06914606
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00857503
14Collecting duct acid secretion_Homo sapiens_hsa049661.94828193
15Huntingtons disease_Homo sapiens_hsa050161.88036259
16Butanoate metabolism_Homo sapiens_hsa006501.85810467
17Fatty acid elongation_Homo sapiens_hsa000621.84019697
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78316907
19Pyrimidine metabolism_Homo sapiens_hsa002401.75898408
20Spliceosome_Homo sapiens_hsa030401.74815418
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74213895
22Phagosome_Homo sapiens_hsa041451.73643193
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72203023
24Legionellosis_Homo sapiens_hsa051341.71691141
25Propanoate metabolism_Homo sapiens_hsa006401.70867235
26Mismatch repair_Homo sapiens_hsa034301.70478483
27Cell cycle_Homo sapiens_hsa041101.70384857
28Nucleotide excision repair_Homo sapiens_hsa034201.69311664
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69282840
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63780613
31Folate biosynthesis_Homo sapiens_hsa007901.53373786
32Synaptic vesicle cycle_Homo sapiens_hsa047211.52611637
33GABAergic synapse_Homo sapiens_hsa047271.49311571
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48679518
35Peroxisome_Homo sapiens_hsa041461.47635346
36Basal transcription factors_Homo sapiens_hsa030221.47368053
37N-Glycan biosynthesis_Homo sapiens_hsa005101.45464466
38Nitrogen metabolism_Homo sapiens_hsa009101.43126204
39Alzheimers disease_Homo sapiens_hsa050101.41280632
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41209808
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41136631
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39670933
43Regulation of autophagy_Homo sapiens_hsa041401.39524452
44Lysosome_Homo sapiens_hsa041421.34308760
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31632470
46Shigellosis_Homo sapiens_hsa051311.27732863
47Steroid biosynthesis_Homo sapiens_hsa001001.23638919
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21227141
49Oocyte meiosis_Homo sapiens_hsa041141.19876238
50Epstein-Barr virus infection_Homo sapiens_hsa051691.17644340
51Ribosome_Homo sapiens_hsa030101.12737702
52Circadian entrainment_Homo sapiens_hsa047131.10520954
53Base excision repair_Homo sapiens_hsa034101.10238864
54Glutathione metabolism_Homo sapiens_hsa004801.09751448
55Morphine addiction_Homo sapiens_hsa050321.09599302
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08117694
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08112539
58Purine metabolism_Homo sapiens_hsa002301.07489651
59Phototransduction_Homo sapiens_hsa047441.06117605
60RNA degradation_Homo sapiens_hsa030181.05925260
61Salmonella infection_Homo sapiens_hsa051321.03685562
62Rheumatoid arthritis_Homo sapiens_hsa053231.02423382
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02106892
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00620788
65Pentose phosphate pathway_Homo sapiens_hsa000301.00301911
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96135302
67Fanconi anemia pathway_Homo sapiens_hsa034600.94904430
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92681591
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92448093
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.91134836
71p53 signaling pathway_Homo sapiens_hsa041150.89628722
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.85620667
73Amphetamine addiction_Homo sapiens_hsa050310.85397737
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85224091
75Type I diabetes mellitus_Homo sapiens_hsa049400.84520799
76Taste transduction_Homo sapiens_hsa047420.84499485
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83590204
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81712540
79Prion diseases_Homo sapiens_hsa050200.81621716
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81612681
81Galactose metabolism_Homo sapiens_hsa000520.81236568
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80212227
83Alcoholism_Homo sapiens_hsa050340.79669081
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78889715
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77777569
86Renin-angiotensin system_Homo sapiens_hsa046140.76952226
87Olfactory transduction_Homo sapiens_hsa047400.76366235
88Viral carcinogenesis_Homo sapiens_hsa052030.75619315
89beta-Alanine metabolism_Homo sapiens_hsa004100.74082303
90Antigen processing and presentation_Homo sapiens_hsa046120.72949494
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72461353
92Pancreatic secretion_Homo sapiens_hsa049720.71152839
93Long-term depression_Homo sapiens_hsa047300.71065867
94Homologous recombination_Homo sapiens_hsa034400.70918417
95Thyroid cancer_Homo sapiens_hsa052160.70351264
96Chemical carcinogenesis_Homo sapiens_hsa052040.70196357
97Glutamatergic synapse_Homo sapiens_hsa047240.67147522
98Salivary secretion_Homo sapiens_hsa049700.66693103
99Fatty acid metabolism_Homo sapiens_hsa012120.65017555
100Serotonergic synapse_Homo sapiens_hsa047260.64067079
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63957993
102Pertussis_Homo sapiens_hsa051330.63866450
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63383962
104Insulin secretion_Homo sapiens_hsa049110.63084395
105Sulfur metabolism_Homo sapiens_hsa009200.62304157
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61695529
107Systemic lupus erythematosus_Homo sapiens_hsa053220.61304321
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57105334
109Pyruvate metabolism_Homo sapiens_hsa006200.57007054
110Fructose and mannose metabolism_Homo sapiens_hsa000510.56345869
111Tuberculosis_Homo sapiens_hsa051520.56250923
112Ether lipid metabolism_Homo sapiens_hsa005650.53684958
113Sphingolipid metabolism_Homo sapiens_hsa006000.52425657
114Tryptophan metabolism_Homo sapiens_hsa003800.49299735
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48773370
116mRNA surveillance pathway_Homo sapiens_hsa030150.48568807
117Other glycan degradation_Homo sapiens_hsa005110.47874044
118Sulfur relay system_Homo sapiens_hsa041220.45588840
119Renin secretion_Homo sapiens_hsa049240.45500780
120Endocytosis_Homo sapiens_hsa041440.45043080
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.43623495
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43480765
123Circadian rhythm_Homo sapiens_hsa047100.42399964
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41804278
125Tyrosine metabolism_Homo sapiens_hsa003500.39990949
126Carbon metabolism_Homo sapiens_hsa012000.38773314
127Selenocompound metabolism_Homo sapiens_hsa004500.37279229
128Colorectal cancer_Homo sapiens_hsa052100.36647983
129Apoptosis_Homo sapiens_hsa042100.35499295
130TGF-beta signaling pathway_Homo sapiens_hsa043500.35396399
131Long-term potentiation_Homo sapiens_hsa047200.32599510
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31868838
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.31654319
134Cardiac muscle contraction_Homo sapiens_hsa042600.31057260
135Metabolic pathways_Homo sapiens_hsa011000.30316388
136Leishmaniasis_Homo sapiens_hsa051400.29714491
137Dopaminergic synapse_Homo sapiens_hsa047280.28791043
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27845847
139Asthma_Homo sapiens_hsa053100.26636532
140Arachidonic acid metabolism_Homo sapiens_hsa005900.25741026
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25497132
142Hippo signaling pathway_Homo sapiens_hsa043900.23937421
143Hepatitis B_Homo sapiens_hsa051610.21854852
144Mineral absorption_Homo sapiens_hsa049780.21338489
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.19160834
146Renal cell carcinoma_Homo sapiens_hsa052110.18663224
147Biosynthesis of amino acids_Homo sapiens_hsa012300.18263150
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18037764

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