VAMP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.04654312
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.84415467
3regulation of synaptic vesicle exocytosis (GO:2000300)4.72824397
4synaptic vesicle maturation (GO:0016188)4.60614504
5neuron cell-cell adhesion (GO:0007158)4.52819851
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45890010
7neuronal action potential propagation (GO:0019227)4.43847988
8glutamate secretion (GO:0014047)4.30546839
9vocalization behavior (GO:0071625)4.30444514
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23489322
11regulation of synaptic vesicle transport (GO:1902803)4.20119482
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09431587
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03408818
14protein localization to synapse (GO:0035418)3.99799299
15presynaptic membrane assembly (GO:0097105)3.99769565
16locomotory exploration behavior (GO:0035641)3.87743269
17regulation of glutamate receptor signaling pathway (GO:1900449)3.82426804
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.76628095
19inositol phosphate dephosphorylation (GO:0046855)3.75663332
20phosphorylated carbohydrate dephosphorylation (GO:0046838)3.75663332
21neurotransmitter secretion (GO:0007269)3.75463878
22inositol phosphate catabolic process (GO:0071545)3.71971189
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.68398083
24dendritic spine morphogenesis (GO:0060997)3.67950536
25presynaptic membrane organization (GO:0097090)3.63518783
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60608145
27postsynaptic membrane organization (GO:0001941)3.47316442
28synaptic transmission, glutamatergic (GO:0035249)3.46322270
29glutamate receptor signaling pathway (GO:0007215)3.43213082
30transferrin transport (GO:0033572)3.40827824
31neuron-neuron synaptic transmission (GO:0007270)3.39008591
32neurotransmitter-gated ion channel clustering (GO:0072578)3.38281028
33ATP hydrolysis coupled proton transport (GO:0015991)3.33547490
34energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.33547490
35activated T cell proliferation (GO:0050798)3.33541138
36positive regulation of synaptic transmission, GABAergic (GO:0032230)3.32794051
37nerve growth factor signaling pathway (GO:0038180)3.27371115
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26962144
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25182036
40negative regulation of T-helper cell differentiation (GO:0045623)3.25182036
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21283139
42regulation of neuronal synaptic plasticity (GO:0048168)3.20728076
43detection of calcium ion (GO:0005513)3.19205363
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.18031814
45neurotransmitter transport (GO:0006836)3.16453604
46ferric iron transport (GO:0015682)3.16221546
47trivalent inorganic cation transport (GO:0072512)3.16221546
48long-term synaptic potentiation (GO:0060291)3.14577003
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14314541
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.14153063
51regulation of neurotransmitter secretion (GO:0046928)3.14036113
52positive regulation of membrane potential (GO:0045838)3.14030398
53startle response (GO:0001964)3.12962303
54proline transport (GO:0015824)3.12314699
55synaptic vesicle endocytosis (GO:0048488)3.08617056
56exploration behavior (GO:0035640)3.07102980
57regulation of postsynaptic membrane potential (GO:0060078)3.06940865
58negative regulation of dendrite morphogenesis (GO:0050774)3.06192407
59positive regulation of mitochondrial fission (GO:0090141)3.02671326
60regulation of vesicle fusion (GO:0031338)3.02112145
61glycosphingolipid biosynthetic process (GO:0006688)3.01794431
62vesicle transport along microtubule (GO:0047496)3.01410052
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00782745
64gamma-aminobutyric acid transport (GO:0015812)2.99981899
65regulation of synaptic transmission, glutamatergic (GO:0051966)2.99112444
66phagosome maturation (GO:0090382)2.98299368
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97721139
68calcium ion-dependent exocytosis (GO:0017156)2.97424214
69cellular potassium ion homeostasis (GO:0030007)2.97043932
70neuromuscular process controlling posture (GO:0050884)2.96505807
71regulation of synapse structural plasticity (GO:0051823)2.95642678
72regulation of synaptic transmission, GABAergic (GO:0032228)2.93943315
73regulation of clathrin-mediated endocytosis (GO:2000369)2.93811549
74membrane depolarization during action potential (GO:0086010)2.92654984
75cerebellar Purkinje cell differentiation (GO:0021702)2.90785168
76regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.89518910
77negative regulation of neurotransmitter transport (GO:0051589)2.88920326
78regulation of neurotransmitter transport (GO:0051588)2.87679779
79negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86905595
80negative regulation of cell killing (GO:0031342)2.86905595
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83144595
82regulation of neurotransmitter levels (GO:0001505)2.82849188
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82463219
84neuron recognition (GO:0008038)2.81803711
85regulation of synaptic plasticity (GO:0048167)2.81776767
86regulation of memory T cell differentiation (GO:0043380)2.81688568
87positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.80837571
88positive regulation of granulocyte differentiation (GO:0030854)2.80145374
89activation of protein kinase A activity (GO:0034199)2.79650187
90synaptic vesicle transport (GO:0048489)2.79108354
91establishment of synaptic vesicle localization (GO:0097480)2.79108354
92membrane depolarization (GO:0051899)2.78199480
93transmission of nerve impulse (GO:0019226)2.76451157
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76408861
95long-term memory (GO:0007616)2.74012698
96neural tube formation (GO:0001841)2.72984130
97positive regulation of synapse assembly (GO:0051965)2.71958850
98response to histamine (GO:0034776)2.70250615
99regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.69851858
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69544409
101positive regulation of synaptic transmission (GO:0050806)2.68636438
102protein localization to cilium (GO:0061512)2.68280264
103innervation (GO:0060384)2.67782357
104synapse assembly (GO:0007416)2.66428350
105establishment of vesicle localization (GO:0051650)2.66253055
106negative regulation of neurotransmitter secretion (GO:0046929)2.66034849
107regulation of voltage-gated calcium channel activity (GO:1901385)2.65768952
108synaptic transmission (GO:0007268)2.65609601
109regulation of amyloid precursor protein catabolic process (GO:1902991)2.65459581
110regulation of exocytosis (GO:0017157)2.65254820
111positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.64526828
112negative regulation of type 2 immune response (GO:0002829)2.62314053
113positive regulation of exocytosis (GO:0045921)2.61306718
114regulation of synaptic transmission (GO:0050804)2.60423266
115regulation of glutamate secretion (GO:0014048)2.60221654
116regulation of regulatory T cell differentiation (GO:0045589)2.58887827
117learning (GO:0007612)2.58590475
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58109489
119polyol catabolic process (GO:0046174)2.58065845
120regulation of respiratory system process (GO:0044065)2.56007378
121regulation of cAMP-dependent protein kinase activity (GO:2000479)2.55356027
122intra-Golgi vesicle-mediated transport (GO:0006891)2.55235616
123succinate metabolic process (GO:0006105)2.55205296
124regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53183074
125membrane hyperpolarization (GO:0060081)2.52125648
126regulation of beta-amyloid formation (GO:1902003)2.51465003
127insulin secretion (GO:0030073)2.51303391
128protein targeting to Golgi (GO:0000042)2.51255055
129actin nucleation (GO:0045010)2.51158940
130response to auditory stimulus (GO:0010996)2.50273590
131poly(A)+ mRNA export from nucleus (GO:0016973)2.49564181
132positive regulation of meiosis (GO:0045836)2.47680283
133retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42601396
134negative regulation of interleukin-17 production (GO:0032700)2.40788069
135positive regulation of neurotransmitter secretion (GO:0001956)2.40640524
136negative regulation of dendrite development (GO:2000171)2.40329641
137establishment of protein localization to Golgi (GO:0072600)2.40313338
138positive regulation of gamma-delta T cell activation (GO:0046645)2.35928726
139peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.31534455
140negative regulation of membrane potential (GO:0045837)2.29682796
141regulation of T-helper 2 cell differentiation (GO:0045628)2.28607894
142auditory behavior (GO:0031223)2.28082306
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26504775
144relaxation of smooth muscle (GO:0044557)2.26087454
145clathrin coat assembly (GO:0048268)2.26004311
146astrocyte differentiation (GO:0048708)2.19528021
147positive regulation of meiotic cell cycle (GO:0051446)2.18741686
148glycolipid biosynthetic process (GO:0009247)2.15287204
149parental behavior (GO:0060746)2.14972005
150negative regulation of alpha-beta T cell differentiation (GO:0046639)2.14687477
151positive regulation of neurotransmitter transport (GO:0051590)2.14615058
152growth hormone receptor signaling pathway (GO:0060396)2.14518898
153positive regulation of mast cell activation (GO:0033005)2.14471534
154positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.12736270
155regulation of Rac protein signal transduction (GO:0035020)2.12599743
156regulation of mitochondrial fission (GO:0090140)2.10338874
157positive regulation of Rap GTPase activity (GO:0032854)2.10188284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.02936895
2GBX2_23144817_ChIP-Seq_PC3_Human3.88599272
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82882888
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81814810
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67725249
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57959378
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41853340
8REST_21632747_ChIP-Seq_MESCs_Mouse2.38850236
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38435434
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29386600
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28750087
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24473674
13TAF15_26573619_Chip-Seq_HEK293_Human2.21239280
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21154533
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20960137
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18643789
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.17529607
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16818976
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16818976
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.01401236
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00329187
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98497309
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.97967986
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95406711
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91688527
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89430149
27SMAD4_21799915_ChIP-Seq_A2780_Human1.86954408
28AR_21572438_ChIP-Seq_LNCaP_Human1.85802721
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85149268
30P300_19829295_ChIP-Seq_ESCs_Human1.85097525
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.83612671
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.82046757
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.81697175
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79708912
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.79563315
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77487934
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74269470
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72384056
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67359401
40DROSHA_22980978_ChIP-Seq_HELA_Human1.66730084
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63955552
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62439168
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.61090809
44* EZH2_27294783_Chip-Seq_NPCs_Mouse1.58756045
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57476387
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53879468
47GATA1_22025678_ChIP-Seq_K562_Human1.53550002
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50958313
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49292387
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48436791
51VDR_22108803_ChIP-Seq_LS180_Human1.48274023
52IGF1R_20145208_ChIP-Seq_DFB_Human1.47703080
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46995100
54AR_25329375_ChIP-Seq_VCAP_Human1.45263998
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43077351
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42375234
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.41807971
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41034175
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40062774
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.39252094
61RUNX_20019798_ChIP-Seq_JUKART_Human1.38869727
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36929149
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36929149
64* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36336717
65STAT3_23295773_ChIP-Seq_U87_Human1.35360005
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.34637109
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.34411753
68* ER_23166858_ChIP-Seq_MCF-7_Human1.33559888
69* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30509995
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.29295552
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29035424
72RNF2_27304074_Chip-Seq_NSC_Mouse1.28814181
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.28498876
74* NANOG_18555785_Chip-Seq_ESCs_Mouse1.27204500
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.26020402
76* CRX_20693478_ChIP-Seq_RETINA_Mouse1.25748427
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25538812
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24784788
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23489857
80ZNF274_21170338_ChIP-Seq_K562_Hela1.23114078
81HTT_18923047_ChIP-ChIP_STHdh_Human1.23029987
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22844189
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.22176894
84FUS_26573619_Chip-Seq_HEK293_Human1.22092702
85* TCF4_23295773_ChIP-Seq_U87_Human1.20708368
86* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19642999
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19470908
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19142169
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17708476
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17529856
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17283924
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15491140
93* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13632123
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.13254665
95* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12790781
96* P300_18555785_Chip-Seq_ESCs_Mouse1.12363519
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12127472
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12116082
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.11862026
100* CTCF_18555785_Chip-Seq_ESCs_Mouse1.11294880
101* OCT4_18555785_Chip-Seq_ESCs_Mouse1.10468748
102* NMYC_18555785_Chip-Seq_ESCs_Mouse1.09828823
103EWS_26573619_Chip-Seq_HEK293_Human1.09827893
104* P53_22387025_ChIP-Seq_ESCs_Mouse1.09645826
105RUNX2_22187159_ChIP-Seq_PCA_Human1.09585230
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08642900
107* PU1_27457419_Chip-Seq_LIVER_Mouse1.08627594
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08147863
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07440271
110* E2F1_18555785_Chip-Seq_ESCs_Mouse1.06488820
111* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05613694
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05566370
113* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05505397
114JUN_21703547_ChIP-Seq_K562_Human1.05347861
115* IRF8_27001747_Chip-Seq_BMDM_Mouse1.04261938
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03625326
117BCAT_22108803_ChIP-Seq_LS180_Human1.03226673
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02882564
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02240686
120* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02162745
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01544060
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00746810
123TP53_18474530_ChIP-ChIP_U2OS_Human1.00307701
124KDM2B_26808549_Chip-Seq_REH_Human1.00095925
125SMAD3_21741376_ChIP-Seq_ESCs_Human1.00008828
126* KLF4_18555785_Chip-Seq_ESCs_Mouse0.99793399
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98014640
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97206239
129CBP_20019798_ChIP-Seq_JUKART_Human0.97206239
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.95477585
131* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95242532
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94983545
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94843513
134* SOX2_18555785_Chip-Seq_ESCs_Mouse0.94351105
135* STAT3_18555785_Chip-Seq_ESCs_Mouse0.94261378
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.93845607
137AR_19668381_ChIP-Seq_PC3_Human0.93472465
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92050555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.82903494
2MP0003880_abnormal_central_pattern4.45075395
3MP0003635_abnormal_synaptic_transmissio3.53956924
4MP0001968_abnormal_touch/_nociception3.31202125
5MP0004270_analgesia3.26250710
6MP0009745_abnormal_behavioral_response3.11046106
7MP0002735_abnormal_chemical_nociception3.04832895
8MP0002064_seizures3.03547301
9MP0009046_muscle_twitch2.92501547
10MP0002063_abnormal_learning/memory/cond2.82076618
11MP0002736_abnormal_nociception_after2.70763348
12MP0003724_increased_susceptibility_to2.67861214
13MP0002572_abnormal_emotion/affect_behav2.63794864
14MP0002734_abnormal_mechanical_nocicepti2.57599924
15MP0002272_abnormal_nervous_system2.45063331
16MP0006276_abnormal_autonomic_nervous2.21834663
17MP0001970_abnormal_pain_threshold2.19951031
18MP0002733_abnormal_thermal_nociception2.19751587
19MP0005645_abnormal_hypothalamus_physiol2.14111337
20MP0005423_abnormal_somatic_nervous2.13913651
21MP0005646_abnormal_pituitary_gland2.10223963
22MP0002822_catalepsy2.08267518
23MP0001486_abnormal_startle_reflex2.06424045
24MP0001501_abnormal_sleep_pattern2.05664379
25MP0005464_abnormal_platelet_physiology2.01330147
26MP0009780_abnormal_chondrocyte_physiolo2.00827547
27MP0002067_abnormal_sensory_capabilities1.99355681
28MP0002638_abnormal_pupillary_reflex1.96850537
29MP0010386_abnormal_urinary_bladder1.96780424
30MP0001440_abnormal_grooming_behavior1.89769228
31MP0002909_abnormal_adrenal_gland1.84813705
32MP0001986_abnormal_taste_sensitivity1.80838745
33MP0008877_abnormal_DNA_methylation1.77969410
34MP0001984_abnormal_olfaction1.77485017
35MP0006082_CNS_inflammation1.73278149
36MP0003787_abnormal_imprinting1.70953580
37MP0003122_maternal_imprinting1.67527410
38MP0001502_abnormal_circadian_rhythm1.63172425
39MP0001905_abnormal_dopamine_level1.61567321
40MP0008569_lethality_at_weaning1.60053935
41MP0003183_abnormal_peptide_metabolism1.59517648
42MP0002184_abnormal_innervation1.59367176
43MP0005386_behavior/neurological_phenoty1.55532384
44MP0004924_abnormal_behavior1.55532384
45MP0002557_abnormal_social/conspecific_i1.50467372
46MP0001529_abnormal_vocalization1.48389706
47MP0004142_abnormal_muscle_tone1.46362009
48MP0005171_absent_coat_pigmentation1.45455750
49MP0004811_abnormal_neuron_physiology1.45225821
50MP0004858_abnormal_nervous_system1.44270308
51MP0000778_abnormal_nervous_system1.41700068
52MP0001835_abnormal_antigen_presentation1.38694546
53MP0003656_abnormal_erythrocyte_physiolo1.36747452
54MP0003633_abnormal_nervous_system1.35695953
55MP0005174_abnormal_tail_pigmentation1.35120606
56MP0000955_abnormal_spinal_cord1.31274831
57MP0003879_abnormal_hair_cell1.29593954
58MP0001188_hyperpigmentation1.27334052
59MP0005075_abnormal_melanosome_morpholog1.26951707
60MP0002066_abnormal_motor_capabilities/c1.25401526
61MP0005167_abnormal_blood-brain_barrier1.25335397
62MP0000013_abnormal_adipose_tissue1.24383891
63MP0002882_abnormal_neuron_morphology1.22984401
64MP0003195_calcinosis1.21741248
65MP0003121_genomic_imprinting1.19536971
66MP0003329_amyloid_beta_deposits1.15548742
67MP0003303_peritoneal_inflammation1.13929888
68MP0001542_abnormal_bone_strength1.13165523
69MP0002876_abnormal_thyroid_physiology1.12842401
70MP0001790_abnormal_immune_system1.12250962
71MP0005387_immune_system_phenotype1.12250962
72MP0009785_altered_susceptibility_to1.12111445
73MP0004134_abnormal_chest_morphology1.09189885
74MP0000920_abnormal_myelination1.07593981
75MP0005379_endocrine/exocrine_gland_phen1.06127690
76MP0002928_abnormal_bile_duct1.05744794
77MP0005551_abnormal_eye_electrophysiolog1.05674068
78MP0005671_abnormal_response_to1.05041817
79MP0002229_neurodegeneration1.03457108
80MP0001299_abnormal_eye_distance/1.03226761
81MP0003631_nervous_system_phenotype1.03184982
82MP0003634_abnormal_glial_cell1.02493494
83MP0000372_irregular_coat_pigmentation1.02404377
84MP0004215_abnormal_myocardial_fiber1.00368237
85MP0000465_gastrointestinal_hemorrhage1.00356189
86MP0002148_abnormal_hypersensitivity_rea0.99163787
87MP0002095_abnormal_skin_pigmentation0.98183763
88MP0004484_altered_response_of0.97178428
89MP0004885_abnormal_endolymph0.93827692
90MP0004043_abnormal_pH_regulation0.89968083
91MP0001800_abnormal_humoral_immune0.89555191
92MP0005535_abnormal_body_temperature0.89331193
93MP0002723_abnormal_immune_serum0.88752465
94MP0002693_abnormal_pancreas_physiology0.88445612
95MP0000230_abnormal_systemic_arterial0.88248727
96MP0000343_altered_response_to0.88235959
97MP0006072_abnormal_retinal_apoptosis0.87284910
98MP0005000_abnormal_immune_tolerance0.86973783
99MP0005084_abnormal_gallbladder_morpholo0.86329940
100MP0003690_abnormal_glial_cell0.86244570
101MP0004742_abnormal_vestibular_system0.86127999
102MP0000631_abnormal_neuroendocrine_gland0.84122223
103MP0002163_abnormal_gland_morphology0.83835538
104MP0003172_abnormal_lysosome_physiology0.83201392
105MP0001756_abnormal_urination0.81160277
106MP0005310_abnormal_salivary_gland0.80151657
107MP0001963_abnormal_hearing_physiology0.79905275
108MP0008874_decreased_physiological_sensi0.79685753
109MP0000569_abnormal_digit_pigmentation0.79423746
110MP0002069_abnormal_eating/drinking_beha0.79192042
111MP0005253_abnormal_eye_physiology0.79071726
112MP0002837_dystrophic_cardiac_calcinosis0.78209142
113MP0006036_abnormal_mitochondrial_physio0.75249128
114MP0002419_abnormal_innate_immunity0.75039500
115MP0004145_abnormal_muscle_electrophysio0.75008458
116MP0003828_pulmonary_edema0.74177311
117MP0003763_abnormal_thymus_physiology0.74077558
118MP0004510_myositis0.73903200
119MP0002090_abnormal_vision0.73817871
120MP0000604_amyloidosis0.72899087
121MP0002152_abnormal_brain_morphology0.72831778
122MP0008260_abnormal_autophagy0.72691724
123MP0002752_abnormal_somatic_nervous0.66890388
124MP0000015_abnormal_ear_pigmentation0.62625062
125MP0002751_abnormal_autonomic_nervous0.59806826
126MP0005410_abnormal_fertilization0.58881706
127MP0005499_abnormal_olfactory_system0.57414337
128MP0005394_taste/olfaction_phenotype0.57414337
129MP0001664_abnormal_digestion0.57369920
130MP0001765_abnormal_ion_homeostasis0.57224386
131MP0003075_altered_response_to0.56819201
132MP0004085_abnormal_heartbeat0.55974820
133MP0003136_yellow_coat_color0.55174080
134MP0003632_abnormal_nervous_system0.55155311
135MP0000681_abnormal_thyroid_gland0.52202480

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.98247525
2Myokymia (HP:0002411)5.41948034
3Atonic seizures (HP:0010819)5.12921792
4Epileptic encephalopathy (HP:0200134)4.67972772
5Febrile seizures (HP:0002373)4.56353707
6Focal seizures (HP:0007359)4.50300219
7Visual hallucinations (HP:0002367)4.16725882
8Metaphyseal dysplasia (HP:0100255)3.92420071
9Absence seizures (HP:0002121)3.92089166
10Pheochromocytoma (HP:0002666)3.84787673
11Hyperventilation (HP:0002883)3.78629953
12Progressive cerebellar ataxia (HP:0002073)3.75063869
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.64974160
14Dialeptic seizures (HP:0011146)3.64921298
15Neuroendocrine neoplasm (HP:0100634)3.62727025
16Generalized tonic-clonic seizures (HP:0002069)3.34807925
17Action tremor (HP:0002345)3.09940584
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.05414328
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.05414328
20Abnormality of calcium-phosphate metabolism (HP:0100530)3.01009144
21Intention tremor (HP:0002080)3.00629362
22Hypothermia (HP:0002045)3.00105713
23Episodic fever (HP:0001954)2.99535570
24Supranuclear gaze palsy (HP:0000605)2.97409621
25Progressive inability to walk (HP:0002505)2.93764859
26Broad-based gait (HP:0002136)2.92232444
27Prolonged bleeding time (HP:0003010)2.85030083
28Medial flaring of the eyebrow (HP:0010747)2.77117837
29Anxiety (HP:0000739)2.77080303
30Gait imbalance (HP:0002141)2.73013916
31Abnormal hair whorl (HP:0010721)2.69492299
32Truncal ataxia (HP:0002078)2.68551908
33Menstrual irregularities (HP:0000858)2.68438907
34Depression (HP:0000716)2.61491803
35Blue irides (HP:0000635)2.61271747
36Increased CSF protein (HP:0002922)2.59511092
37Abnormality of the corticospinal tract (HP:0002492)2.58628099
38Abnormal eating behavior (HP:0100738)2.56527519
39Abnormality of binocular vision (HP:0011514)2.55585684
40Diplopia (HP:0000651)2.55585684
41Agitation (HP:0000713)2.55053324
42Congenital primary aphakia (HP:0007707)2.50899161
43Nephrogenic diabetes insipidus (HP:0009806)2.49148911
44Amblyopia (HP:0000646)2.48250582
45Gaze-evoked nystagmus (HP:0000640)2.46410526
46Ketoacidosis (HP:0001993)2.38407622
47Papilledema (HP:0001085)2.31563502
48Epileptiform EEG discharges (HP:0011182)2.29364986
49Absent speech (HP:0001344)2.28686929
50Excessive salivation (HP:0003781)2.26377332
51Drooling (HP:0002307)2.26377332
52Ankle clonus (HP:0011448)2.22912699
53Limb dystonia (HP:0002451)2.21904762
54Polyphagia (HP:0002591)2.20362130
55Dysmetria (HP:0001310)2.19929618
56Failure to thrive in infancy (HP:0001531)2.19371566
57Mutism (HP:0002300)2.17799739
58Macroorchidism (HP:0000053)2.16006278
59Neoplasm of the peripheral nervous system (HP:0100007)2.15683978
60EEG with generalized epileptiform discharges (HP:0011198)2.14941055
61Hyperthyroidism (HP:0000836)2.12936584
62Papillary thyroid carcinoma (HP:0002895)2.12531301
63Lower limb muscle weakness (HP:0007340)2.12262197
64Thyroid carcinoma (HP:0002890)2.10600357
65Dysdiadochokinesis (HP:0002075)2.09916141
66Abnormality of macular pigmentation (HP:0008002)2.09646245
67Amyotrophic lateral sclerosis (HP:0007354)2.09155034
68Retinal dysplasia (HP:0007973)2.08113352
69Thyroid-stimulating hormone excess (HP:0002925)2.07871718
70Thyroiditis (HP:0100646)2.07675939
71Petechiae (HP:0000967)2.04486941
72Insulin-resistant diabetes mellitus (HP:0000831)2.04261786
73Specific learning disability (HP:0001328)2.02998970
74Psychosis (HP:0000709)2.00762303
75Hematochezia (HP:0002573)2.00178282
76Hypsarrhythmia (HP:0002521)2.00126998
77Genital tract atresia (HP:0001827)1.99976824
78Increased circulating renin level (HP:0000848)1.99335834
79Vaginal atresia (HP:0000148)1.98666709
80Vacuolated lymphocytes (HP:0001922)1.97359513
81Postural instability (HP:0002172)1.97349204
82Hypomagnesemia (HP:0002917)1.96081684
83Spinal canal stenosis (HP:0003416)1.96079142
84Dysostosis multiplex (HP:0000943)1.95303090
85Hypercortisolism (HP:0001578)1.93823169
86Progressive macrocephaly (HP:0004481)1.91674693
87Hypoventilation (HP:0002791)1.91216443
88Poor suck (HP:0002033)1.91141058
89Neurofibrillary tangles (HP:0002185)1.90610976
90Hemiparesis (HP:0001269)1.90231857
91Inability to walk (HP:0002540)1.89496723
92Acute necrotizing encephalopathy (HP:0006965)1.89225208
93Protruding tongue (HP:0010808)1.88679349
94Impaired vibratory sensation (HP:0002495)1.88096996
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.87765587
96Absent/shortened dynein arms (HP:0200106)1.87765587
97Poor eye contact (HP:0000817)1.87690879
98Impaired vibration sensation in the lower limbs (HP:0002166)1.85236245
99Widely spaced teeth (HP:0000687)1.81825016
100Bradykinesia (HP:0002067)1.80921580
101Abolished electroretinogram (ERG) (HP:0000550)1.80840418
102Heterochromia iridis (HP:0001100)1.80818804
103Abnormal mitochondria in muscle tissue (HP:0008316)1.80730114
104Aplasia/Hypoplasia of the lens (HP:0008063)1.79563880
105Decreased circulating renin level (HP:0003351)1.79528006
106T lymphocytopenia (HP:0005403)1.77992160
107Urinary bladder sphincter dysfunction (HP:0002839)1.77514083
108Conjunctival hamartoma (HP:0100780)1.77296041
109Impaired smooth pursuit (HP:0007772)1.76683122
110Abnormality of salivation (HP:0100755)1.76236602
111Constricted visual fields (HP:0001133)1.75968982
112Generalized myoclonic seizures (HP:0002123)1.75895030
113Bundle branch block (HP:0011710)1.74738934
114Type II lissencephaly (HP:0007260)1.74729514
115Sensory axonal neuropathy (HP:0003390)1.74336274
116Neuronal loss in central nervous system (HP:0002529)1.73443639
117Fetal akinesia sequence (HP:0001989)1.72948238
118Neoplasm of the adrenal cortex (HP:0100641)1.72877665
119Hyperglycemia (HP:0003074)1.71790394
120Loss of speech (HP:0002371)1.70752065
121Gait ataxia (HP:0002066)1.70183570
122Torticollis (HP:0000473)1.69573068
123Gingival bleeding (HP:0000225)1.67881609
124Disinhibition (HP:0000734)1.67113881
125Thickened helices (HP:0000391)1.65452376
126Methylmalonic acidemia (HP:0002912)1.64918637
127Elevated erythrocyte sedimentation rate (HP:0003565)1.64429117
128Esotropia (HP:0000565)1.64247553
129Postural tremor (HP:0002174)1.64219263
130Choroideremia (HP:0001139)1.64006562
131Recurrent cutaneous fungal infections (HP:0011370)1.63558971
132Chronic mucocutaneous candidiasis (HP:0002728)1.63558971
133Ulnar claw (HP:0001178)1.63416436
134Abnormality of T cell number (HP:0011839)1.62720871
135Spastic gait (HP:0002064)1.62325376
136Stomatitis (HP:0010280)1.62098371
137Generalized hypopigmentation of hair (HP:0011358)1.61777947
138Exotropia (HP:0000577)1.61020047
139Scanning speech (HP:0002168)1.60663919
140Adrenal overactivity (HP:0002717)1.60610062
141Hyperphosphatemia (HP:0002905)1.60495040
142Poor coordination (HP:0002370)1.60147297
143Decreased central vision (HP:0007663)1.58983379
144Abnormality of liposaccharide metabolism (HP:0010968)1.58870203
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.58870203
146Abnormality of glycolipid metabolism (HP:0010969)1.58870203
147Progressive neurologic deterioration (HP:0002344)1.57628002
148Hemiplegia (HP:0002301)1.56325039
149Split foot (HP:0001839)1.56151751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.67438531
2CASK4.22023692
3MAP3K123.44160654
4RIPK42.99973606
5MAP2K72.74723103
6EPHA42.53327205
7EPHA32.49891489
8MAP3K42.45602563
9MAP3K92.32400515
10PRPF4B2.31769269
11MINK12.07539484
12NTRK11.94594316
13CAMKK21.93202402
14DAPK21.89809944
15ARAF1.84838249
16PLK21.78394619
17KSR21.76319543
18TRIM281.74025942
19TAOK31.73380724
20GRK51.67540640
21BMPR21.64790620
22MARK11.62465747
23PAK61.58119214
24MAP2K41.55664681
25FGFR21.54628823
26BRD41.49539831
27NTRK21.49503064
28MAP3K21.45769875
29MAPK131.41907708
30ERBB31.35211910
31FES1.33436564
32CDK51.31414810
33CAMKK11.31044850
34CDK191.21062900
35TNIK1.20475069
36UHMK11.20363423
37DAPK11.16332256
38PRKD31.15500975
39SIK31.14061024
40MAP3K61.11044619
41PRKCG1.09477813
42TEC1.07700072
43KIT1.04119057
44IRAK11.04087046
45FGFR31.03605306
46MAP3K131.03524587
47CAMK2A1.03159094
48AKT31.02272738
49PRKCH1.02125643
50SGK4941.00902287
51SGK2231.00902287
52TRPM71.00179115
53GRK70.99538161
54MAP3K50.98968124
55KSR10.97689349
56JAK20.94754915
57FGR0.91237609
58SGK20.91175763
59MAP3K10.90872272
60OXSR10.90534619
61TYK20.90408372
62PRKCE0.88005384
63ACVR1B0.81228243
64CAMK2B0.80816002
65ADRBK20.80675193
66PIK3CG0.79897606
67NME10.79793307
68INSRR0.77539927
69EPHB10.77228071
70MAPK70.76140038
71TNK20.75953682
72BCR0.73790255
73FRK0.72968665
74BLK0.72486348
75RAF10.70459819
76CDK140.70085214
77HCK0.68924890
78PTK2B0.68015715
79CSNK1G20.67050929
80TXK0.66601535
81HIPK20.66438330
82STK380.66309005
83RET0.66050135
84SGK10.64430815
85ITK0.64254292
86CAMK2D0.63050016
87ZAP700.62824510
88WNK10.62498046
89CDK180.61857948
90ADRBK10.61428900
91SIK20.61169237
92MAP4K20.60566613
93PINK10.59144497
94BCKDK0.59077541
95PAK30.59014499
96LIMK10.58405966
97LCK0.58090669
98BMPR1B0.57918343
99CSNK1G10.56919561
100CSNK1G30.56639988
101CDK150.55631869
102CAMK2G0.55091014
103BRAF0.54695932
104MAP3K140.54531079
105DYRK1B0.53903390
106SGK30.53706846
107NEK60.52143562
108NUAK10.51910119
109NLK0.50189790
110LYN0.50123815
111CSF1R0.49762960
112MAP4K10.49687139
113MUSK0.49285502
114DYRK1A0.48910055
115CDK11A0.47478056
116CSK0.47414363
117WNK40.46975155
118BTK0.46851169
119MST40.46341750
120PDK10.44117755
121SYK0.43649188
122CLK10.43585420
123FYN0.43163445
124YES10.42794061
125WNK30.41996148
126PDPK10.41896397
127STK110.41564586
128CAMK10.39154196
129IRAK20.37968963
130STK390.37824664
131PHKG20.37568969
132PHKG10.37568969
133PRKCQ0.37029452
134CDC42BPA0.36487254
135PRKG10.36274176
136JAK10.35475533
137PRKACA0.34333408
138PRKCA0.31462965

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.53608488
2Nicotine addiction_Homo sapiens_hsa050333.12016147
3Collecting duct acid secretion_Homo sapiens_hsa049662.87008546
4Olfactory transduction_Homo sapiens_hsa047402.45219100
5GABAergic synapse_Homo sapiens_hsa047272.42123994
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40219036
7Circadian entrainment_Homo sapiens_hsa047132.31408114
8Morphine addiction_Homo sapiens_hsa050322.30175324
9Long-term potentiation_Homo sapiens_hsa047202.25993539
10Amphetamine addiction_Homo sapiens_hsa050312.16172913
11Glutamatergic synapse_Homo sapiens_hsa047242.15238126
12Insulin secretion_Homo sapiens_hsa049112.10785152
13Vibrio cholerae infection_Homo sapiens_hsa051102.08985233
14Dopaminergic synapse_Homo sapiens_hsa047281.96852724
15Taste transduction_Homo sapiens_hsa047421.84201052
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80192744
17Serotonergic synapse_Homo sapiens_hsa047261.79663403
18Cholinergic synapse_Homo sapiens_hsa047251.69961499
19Salivary secretion_Homo sapiens_hsa049701.64664454
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61453093
21Cocaine addiction_Homo sapiens_hsa050301.61121503
22Renin secretion_Homo sapiens_hsa049241.60488230
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52197248
24Oxidative phosphorylation_Homo sapiens_hsa001901.51895695
25Long-term depression_Homo sapiens_hsa047301.49729927
26Gastric acid secretion_Homo sapiens_hsa049711.45390910
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43627874
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42877678
29Type I diabetes mellitus_Homo sapiens_hsa049401.36395914
30Rheumatoid arthritis_Homo sapiens_hsa053231.35279637
31Platelet activation_Homo sapiens_hsa046111.28667248
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27204679
33Calcium signaling pathway_Homo sapiens_hsa040201.27163634
34Oxytocin signaling pathway_Homo sapiens_hsa049211.23611045
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22347926
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22027571
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17405246
38* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16681002
39Alzheimers disease_Homo sapiens_hsa050101.12736595
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12443417
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10972001
42Type II diabetes mellitus_Homo sapiens_hsa049301.09733777
43Phototransduction_Homo sapiens_hsa047441.07902223
44Phagosome_Homo sapiens_hsa041451.07408108
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06843220
46cAMP signaling pathway_Homo sapiens_hsa040241.04854830
47GnRH signaling pathway_Homo sapiens_hsa049121.03041709
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99706693
49Protein export_Homo sapiens_hsa030600.99497553
50Osteoclast differentiation_Homo sapiens_hsa043800.96728515
51Parkinsons disease_Homo sapiens_hsa050120.94507396
52Allograft rejection_Homo sapiens_hsa053300.93651698
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88982288
54Cardiac muscle contraction_Homo sapiens_hsa042600.88695170
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87473515
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.86659822
57Gap junction_Homo sapiens_hsa045400.86131968
58Hematopoietic cell lineage_Homo sapiens_hsa046400.85220723
59Estrogen signaling pathway_Homo sapiens_hsa049150.84550407
60Autoimmune thyroid disease_Homo sapiens_hsa053200.82317817
61Glioma_Homo sapiens_hsa052140.81635534
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81186425
63Pancreatic secretion_Homo sapiens_hsa049720.80131438
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.79139323
65Butanoate metabolism_Homo sapiens_hsa006500.78677385
66ErbB signaling pathway_Homo sapiens_hsa040120.78211425
67Ether lipid metabolism_Homo sapiens_hsa005650.77091455
68Asthma_Homo sapiens_hsa053100.76584940
69Dorso-ventral axis formation_Homo sapiens_hsa043200.75585190
70Lysosome_Homo sapiens_hsa041420.75420256
71Melanogenesis_Homo sapiens_hsa049160.72115628
72Legionellosis_Homo sapiens_hsa051340.71426550
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71084094
74Axon guidance_Homo sapiens_hsa043600.69341954
75Leishmaniasis_Homo sapiens_hsa051400.68162589
76Fatty acid elongation_Homo sapiens_hsa000620.67903782
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66929761
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66180782
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64940079
80Chemokine signaling pathway_Homo sapiens_hsa040620.64913384
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64793478
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64717061
83MAPK signaling pathway_Homo sapiens_hsa040100.64488611
84Thyroid hormone synthesis_Homo sapiens_hsa049180.61655598
85mTOR signaling pathway_Homo sapiens_hsa041500.61264056
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60771614
87Ras signaling pathway_Homo sapiens_hsa040140.59899711
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59511651
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.59236963
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.58563281
91Huntingtons disease_Homo sapiens_hsa050160.57550491
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.57042771
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56223218
94Tuberculosis_Homo sapiens_hsa051520.55719650
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55064626
96Endocytosis_Homo sapiens_hsa041440.53832908
97Inositol phosphate metabolism_Homo sapiens_hsa005620.53612328
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.53136426
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52565649
100B cell receptor signaling pathway_Homo sapiens_hsa046620.51675016
101Regulation of autophagy_Homo sapiens_hsa041400.51507431
102Shigellosis_Homo sapiens_hsa051310.50812683
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50262894
104Choline metabolism in cancer_Homo sapiens_hsa052310.48515445
105Pertussis_Homo sapiens_hsa051330.48460793
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48192030
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47102977
108Alcoholism_Homo sapiens_hsa050340.45896518
109FoxO signaling pathway_Homo sapiens_hsa040680.44757841
110Circadian rhythm_Homo sapiens_hsa047100.44569259
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.44541576
112Staphylococcus aureus infection_Homo sapiens_hsa051500.43401102
113Salmonella infection_Homo sapiens_hsa051320.42058276
114Prion diseases_Homo sapiens_hsa050200.41948445
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41367842
116African trypanosomiasis_Homo sapiens_hsa051430.40317835
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38881771
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37035241
119Glucagon signaling pathway_Homo sapiens_hsa049220.36422871
120Sphingolipid metabolism_Homo sapiens_hsa006000.35556662
121T cell receptor signaling pathway_Homo sapiens_hsa046600.35516609
122Rap1 signaling pathway_Homo sapiens_hsa040150.34601135
123VEGF signaling pathway_Homo sapiens_hsa043700.34330186
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33554652
125Graft-versus-host disease_Homo sapiens_hsa053320.33131520
126Oocyte meiosis_Homo sapiens_hsa041140.33077879
127Prolactin signaling pathway_Homo sapiens_hsa049170.31871552
128Renal cell carcinoma_Homo sapiens_hsa052110.31089187
129Dilated cardiomyopathy_Homo sapiens_hsa054140.30020856

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