VAMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.64717576
2glycine transport (GO:0015816)5.97414702
3neuronal action potential propagation (GO:0019227)5.91706723
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86890059
5positive regulation of gamma-delta T cell activation (GO:0046645)5.71665642
6sodium ion export (GO:0071436)5.50985795
7negative regulation of cell killing (GO:0031342)5.43694863
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.43694863
9neuromuscular process controlling posture (GO:0050884)5.33688031
10cellular potassium ion homeostasis (GO:0030007)5.33676802
11regulation of synaptic vesicle exocytosis (GO:2000300)5.25299451
12synaptic vesicle exocytosis (GO:0016079)5.18501635
13glutamate secretion (GO:0014047)5.14238294
14locomotory exploration behavior (GO:0035641)5.10978478
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.09946669
16neurofilament cytoskeleton organization (GO:0060052)4.95800718
17* neurotransmitter secretion (GO:0007269)4.79576443
18cerebellar Purkinje cell differentiation (GO:0021702)4.76453242
19regulation of synaptic vesicle transport (GO:1902803)4.76184370
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.63017863
21regulation of B cell receptor signaling pathway (GO:0050855)4.58518976
22leukocyte aggregation (GO:0070486)4.56899596
23gamma-aminobutyric acid transport (GO:0015812)4.53450280
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.50877608
25L-amino acid import (GO:0043092)4.46955701
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.44807310
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38886663
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.35804046
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.33169688
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.33155272
31potassium ion import (GO:0010107)4.32761219
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30289131
33proline transport (GO:0015824)4.25420752
34antigen processing and presentation of endogenous antigen (GO:0019883)4.14383817
35potassium ion homeostasis (GO:0055075)4.12496153
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.11913221
37negative regulation of T cell mediated immunity (GO:0002710)4.10906435
38regulation of gamma-delta T cell activation (GO:0046643)4.10493300
39* neurotransmitter transport (GO:0006836)4.09533285
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.08229221
41regulation of gamma-delta T cell differentiation (GO:0045586)4.06980156
42positive thymic T cell selection (GO:0045059)4.05337879
43cell communication by electrical coupling (GO:0010644)4.00298372
44vocalization behavior (GO:0071625)3.99110672
45B cell receptor signaling pathway (GO:0050853)3.99080169
46response to interleukin-15 (GO:0070672)3.97668916
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.96605706
48negative thymic T cell selection (GO:0045060)3.96535628
49ionotropic glutamate receptor signaling pathway (GO:0035235)3.94754518
50regulation of neuronal synaptic plasticity (GO:0048168)3.87737832
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.86429276
52membrane depolarization during action potential (GO:0086010)3.84096347
53negative T cell selection (GO:0043383)3.83320447
54regulation of glutamate receptor signaling pathway (GO:1900449)3.82872797
55positive regulation of potassium ion transmembrane transport (GO:1901381)3.73744974
56negative regulation of erythrocyte differentiation (GO:0045647)3.73175632
57positive regulation of Rap GTPase activity (GO:0032854)3.72175373
58activation of protein kinase A activity (GO:0034199)3.70133152
59exploration behavior (GO:0035640)3.68535225
60cellular response to interleukin-15 (GO:0071350)3.68088617
61axon cargo transport (GO:0008088)3.67240820
62* regulation of neurotransmitter levels (GO:0001505)3.65527225
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.65521078
64negative regulation of leukocyte mediated immunity (GO:0002704)3.62669753
65thymic T cell selection (GO:0045061)3.60029764
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.56282688
67positive T cell selection (GO:0043368)3.55313443
68synaptic vesicle endocytosis (GO:0048488)3.53952931
69regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53859323
70protein localization to synapse (GO:0035418)3.51880186
71cellular sodium ion homeostasis (GO:0006883)3.51272517
72adult walking behavior (GO:0007628)3.51171693
73neuron-neuron synaptic transmission (GO:0007270)3.49910394
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.49008728
75synaptic transmission, glutamatergic (GO:0035249)3.48365086
76neuromuscular process controlling balance (GO:0050885)3.43068302
77signal complex assembly (GO:0007172)3.42792304
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40821868
79amino acid import (GO:0043090)3.36898590
80T cell selection (GO:0045058)3.35784433
81vesicle transport along microtubule (GO:0047496)3.35461180
82positive regulation of potassium ion transport (GO:0043268)3.34704975
83T cell migration (GO:0072678)3.34080962
84regulation of neurotransmitter secretion (GO:0046928)3.33985973
85glutamate receptor signaling pathway (GO:0007215)3.33805454
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31696196
87long-term memory (GO:0007616)3.31330868
88layer formation in cerebral cortex (GO:0021819)3.30098181
89macrophage activation involved in immune response (GO:0002281)3.28905249
90positive regulation of B cell differentiation (GO:0045579)3.27969519
91regulation of Rap GTPase activity (GO:0032317)3.26201543
92regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25000053
93transmission of nerve impulse (GO:0019226)3.20513318
94regulation of synapse structural plasticity (GO:0051823)3.20379668
95regulation of ARF protein signal transduction (GO:0032012)3.19667162
96regulation of neurotransmitter transport (GO:0051588)3.18091752
97neuromuscular synaptic transmission (GO:0007274)3.16125783
98activation of MAPKKK activity (GO:0000185)3.14634660
99neuromuscular process (GO:0050905)3.13751436
100modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.12427314
101positive regulation by organism of defense response of other organism involved in symbiotic interact3.12427314
102modulation by symbiont of host immune response (GO:0052553)3.12427314
103positive regulation by symbiont of host defense response (GO:0052509)3.12427314
104modulation by symbiont of host defense response (GO:0052031)3.12427314
105modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.12427314
106detection of bacterium (GO:0016045)3.10774420
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10428276
108membrane repolarization (GO:0086009)3.08712790
109germinal center formation (GO:0002467)3.08246633
110regulation of B cell differentiation (GO:0045577)3.08244246
111detection of other organism (GO:0098543)3.07562189
112neuron cell-cell adhesion (GO:0007158)3.07477245
113cell differentiation in hindbrain (GO:0021533)3.04282249
114cell migration in hindbrain (GO:0021535)3.00302691
115membrane hyperpolarization (GO:0060081)3.00261826
116regulation of alpha-beta T cell proliferation (GO:0046640)2.98164706
117response to auditory stimulus (GO:0010996)2.98129822
118organelle transport along microtubule (GO:0072384)2.96260050
119cell communication involved in cardiac conduction (GO:0086065)2.95705288
120neuronal ion channel clustering (GO:0045161)2.95651203
121negative regulation of microtubule polymerization (GO:0031115)2.95173985
122regulation of synaptic plasticity (GO:0048167)2.94968951
123regulation of clathrin-mediated endocytosis (GO:2000369)2.94684033
124regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.94549495
125membrane depolarization (GO:0051899)2.94046254
126regulation of vesicle fusion (GO:0031338)2.93221335
127regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93120643
128* synaptic transmission (GO:0007268)2.92325119
129negative regulation of dendrite morphogenesis (GO:0050774)2.91644139
130cerebellar granule cell differentiation (GO:0021707)2.88564170
131negative regulation of type 2 immune response (GO:0002829)2.88434569
132interferon-gamma production (GO:0032609)2.87214804
133regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86326136
134mating behavior (GO:0007617)2.85720494
135mast cell activation (GO:0045576)2.85600655
136regulation of postsynaptic membrane potential (GO:0060078)2.84948578
137neurotransmitter uptake (GO:0001504)2.84780283
138calcium ion-dependent exocytosis (GO:0017156)2.83925900
139positive regulation of granulocyte differentiation (GO:0030854)2.82984667
140response to pheromone (GO:0019236)2.82768436
141prepulse inhibition (GO:0060134)2.82760989
142positive regulation of membrane potential (GO:0045838)2.82189689
143activated T cell proliferation (GO:0050798)2.81373105
144gamma-aminobutyric acid signaling pathway (GO:0007214)2.80076536
145mucosal-associated lymphoid tissue development (GO:0048537)2.79626122
146Peyers patch development (GO:0048541)2.79626122
147positive regulation of type 2 immune response (GO:0002830)2.79463517
148regulation of voltage-gated calcium channel activity (GO:1901385)2.79085484
149righting reflex (GO:0060013)2.78962248
150long-term synaptic potentiation (GO:0060291)2.78915275
151mast cell activation involved in immune response (GO:0002279)2.77331731
152mast cell degranulation (GO:0043303)2.77331731
153negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.76639530
154cellular extravasation (GO:0045123)2.76612535
155dendrite morphogenesis (GO:0048813)2.75860922
156positive regulation of synapse maturation (GO:0090129)2.75433367
157antigen receptor-mediated signaling pathway (GO:0050851)2.75056795
158membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74843748
159regulation of T-helper 2 cell differentiation (GO:0045628)2.74688244
160positive regulation of synaptic transmission, GABAergic (GO:0032230)2.74553299
161regulation of synaptic transmission (GO:0050804)2.73267419
162myeloid cell activation involved in immune response (GO:0002275)2.70112053
163natural killer cell differentiation (GO:0001779)2.68768844
164regulation of regulated secretory pathway (GO:1903305)2.64263679
165regulation of type 2 immune response (GO:0002828)2.63833862
166T cell homeostasis (GO:0043029)2.62153029
167response to muramyl dipeptide (GO:0032495)2.61218193
168positive regulation of T cell cytokine production (GO:0002726)2.58075465
169interferon-gamma-mediated signaling pathway (GO:0060333)2.57682801
170positive regulation of alpha-beta T cell proliferation (GO:0046641)2.56757461
171negative regulation of alpha-beta T cell activation (GO:0046636)2.55990908
172regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.55196529
173response to type I interferon (GO:0034340)2.54321433
174regulation of amyloid precursor protein catabolic process (GO:1902991)2.54038504
175cellular response to type I interferon (GO:0071357)2.53935143
176type I interferon signaling pathway (GO:0060337)2.53935143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03097982
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.65764327
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.64908013
4MYC_22102868_ChIP-Seq_BL_Human3.19148365
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00586419
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92723534
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87962089
8GBX2_23144817_ChIP-Seq_PC3_Human2.79559883
9VDR_21846776_ChIP-Seq_THP-1_Human2.78975689
10DROSHA_22980978_ChIP-Seq_HELA_Human2.78072005
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77951250
12REST_21632747_ChIP-Seq_MESCs_Mouse2.70893609
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70323761
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70323761
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.62071313
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55021136
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53723675
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52255092
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.51046344
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49943820
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49243951
22KDM2B_26808549_Chip-Seq_DND41_Human2.47476543
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.44662288
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.44273209
25MAF_26560356_Chip-Seq_TH1_Human2.39081107
26* RUNX_20019798_ChIP-Seq_JUKART_Human2.39079953
27* TCF7_22412390_ChIP-Seq_EML_Mouse2.38858581
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33894086
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29446649
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28055021
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26580230
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26149212
33REST_18959480_ChIP-ChIP_MESCs_Mouse2.25070928
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21308252
35UTX_26944678_Chip-Seq_JUKART_Human2.16033016
36SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15159452
37EZH2_27294783_Chip-Seq_ESCs_Mouse2.13829199
38LXR_22292898_ChIP-Seq_THP-1_Human2.12831327
39* MAF_26560356_Chip-Seq_TH2_Human2.11821723
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11629421
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09716369
42VDR_24763502_ChIP-Seq_THP-1_Human2.09079854
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05935082
44RNF2_27304074_Chip-Seq_ESCs_Mouse2.05127115
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02548421
46* MYB_26560356_Chip-Seq_TH2_Human1.99359205
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96997093
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.91707766
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89959411
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89923448
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.88747112
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.88606577
53SPI1_23127762_ChIP-Seq_K562_Human1.84425624
54AR_21572438_ChIP-Seq_LNCaP_Human1.83351282
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.81866648
56* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76979202
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74494318
58SCL_19346495_ChIP-Seq_HPC-7_Human1.71351745
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69964550
60MYB_26560356_Chip-Seq_TH1_Human1.69563328
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.68951493
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68162685
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66369183
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.65247964
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64478089
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57338589
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.56824510
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54645042
69SMAD4_21799915_ChIP-Seq_A2780_Human1.52228424
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51675022
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50871101
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.47264900
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46503943
74* KDM2B_26808549_Chip-Seq_K562_Human1.44874829
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.44601938
76SPI1_23547873_ChIP-Seq_NB4_Human1.43401864
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42818695
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42520270
79GATA3_27048872_Chip-Seq_THYMUS_Human1.37645904
80P68_20966046_ChIP-Seq_HELA_Human1.37481430
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35620310
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35586373
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34813417
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33630919
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.33175761
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32852616
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.32096641
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31332931
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29405685
90CIITA_25753668_ChIP-Seq_RAJI_Human1.27271893
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.26066012
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25868717
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25765271
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.25401230
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25105269
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.23809915
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23794537
98AR_19668381_ChIP-Seq_PC3_Human1.23267652
99STAT3_23295773_ChIP-Seq_U87_Human1.21914032
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21575432
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20553091
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.16936056
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16496655
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15444752
105TAF15_26573619_Chip-Seq_HEK293_Human1.15060149
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14404943
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14133562
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13943774
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13212768
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11643849
111* BCOR_27268052_Chip-Seq_Bcells_Human1.10971077
112* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08998893
113AR_25329375_ChIP-Seq_VCAP_Human1.07352160
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06311939
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05894447
116GATA1_19941826_ChIP-Seq_K562_Human1.05624862
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03750707
118AHR_22903824_ChIP-Seq_MCF-7_Human1.03642606
119BCL6_27268052_Chip-Seq_Bcells_Human1.03159188
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03035909
121ESR2_21235772_ChIP-Seq_MCF-7_Human1.02287385
122CREB1_26743006_Chip-Seq_LNCaP_Human1.02051611
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.00918869
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00297271
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00207227
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99853266
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99792533
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99731243
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99684603
130VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99672347
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99196834
132* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98545465
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97612716
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.97399407
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97192031
136TCF4_23295773_ChIP-Seq_U87_Human0.97148179
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96247972
138* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95635184
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95621115
140SA1_27219007_Chip-Seq_Bcells_Human0.95600668
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95311596
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95304545
143GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95294563
144ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95143935
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94450249
146CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94420878
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.93153531
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92961728
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92921176
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92774944
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92730197
152P300_19829295_ChIP-Seq_ESCs_Human0.92156903
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92029982
154RING1B_27294783_Chip-Seq_NPCs_Mouse0.91323666
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89731879
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.88645001
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.86642307
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85363892
159IGF1R_20145208_ChIP-Seq_DFB_Human0.85269884
160TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85203546
161RXR_22108803_ChIP-Seq_LS180_Human0.85002293
162SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84938948
163ZNF274_21170338_ChIP-Seq_K562_Hela0.84121186
164KLF4_19829295_ChIP-Seq_ESCs_Human0.82648962
165RNF2_27304074_Chip-Seq_NSC_Mouse0.81393041
166SMAD3_21741376_ChIP-Seq_EPCs_Human0.81190860
167DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80784139
168SMAD3_21741376_ChIP-Seq_HESCs_Human0.80525088
169BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80100319
170OCT4_19829295_ChIP-Seq_ESCs_Human0.79773543
171KDM2B_26808549_Chip-Seq_JURKAT_Human0.79755601
172SMC4_20622854_ChIP-Seq_HELA_Human0.78796807
173PIAS1_25552417_ChIP-Seq_VCAP_Human0.78506738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.79240267
2MP0003880_abnormal_central_pattern4.65003706
3MP0003635_abnormal_synaptic_transmissio3.95786358
4MP0009046_muscle_twitch3.87624779
5MP0004270_analgesia3.40410100
6MP0002064_seizures3.26409746
7MP0001968_abnormal_touch/_nociception3.25937827
8MP0009745_abnormal_behavioral_response3.13267906
9MP0003763_abnormal_thymus_physiology3.05429658
10MP0003436_decreased_susceptibility_to3.05306898
11MP0002272_abnormal_nervous_system3.00980695
12MP0005423_abnormal_somatic_nervous2.96217138
13MP0005671_abnormal_response_to2.83287446
14MP0001486_abnormal_startle_reflex2.82923358
15MP0002735_abnormal_chemical_nociception2.79519085
16MP0002063_abnormal_learning/memory/cond2.78439301
17MP0002734_abnormal_mechanical_nocicepti2.77571627
18MP0008569_lethality_at_weaning2.73876899
19MP0003303_peritoneal_inflammation2.64810850
20MP0001800_abnormal_humoral_immune2.64287315
21MP0002736_abnormal_nociception_after2.60052298
22MP0001835_abnormal_antigen_presentation2.59824966
23MP0005000_abnormal_immune_tolerance2.55197756
24MP0002572_abnormal_emotion/affect_behav2.41260702
25MP0004858_abnormal_nervous_system2.40612313
26MP0001501_abnormal_sleep_pattern2.39905250
27MP0002733_abnormal_thermal_nociception2.38463920
28* MP0002067_abnormal_sensory_capabilities2.31131508
29MP0001790_abnormal_immune_system2.30838529
30MP0005387_immune_system_phenotype2.30838529
31MP0004142_abnormal_muscle_tone2.28408770
32MP0001970_abnormal_pain_threshold2.27921189
33MP0000685_abnormal_immune_system2.17660617
34MP0002420_abnormal_adaptive_immunity2.14065620
35MP0002723_abnormal_immune_serum2.12748094
36MP0003724_increased_susceptibility_to2.11585225
37MP0001819_abnormal_immune_cell2.09064510
38MP0002909_abnormal_adrenal_gland2.06991727
39MP0005025_abnormal_response_to2.01607881
40MP0001440_abnormal_grooming_behavior1.98728099
41MP0002419_abnormal_innate_immunity1.95862257
42MP0002452_abnormal_antigen_presenting1.95380563
43MP0006276_abnormal_autonomic_nervous1.95010105
44MP0000955_abnormal_spinal_cord1.94132269
45MP0002184_abnormal_innervation1.88368542
46MP0003329_amyloid_beta_deposits1.85863330
47MP0002398_abnormal_bone_marrow1.85198178
48MP0004811_abnormal_neuron_physiology1.85160101
49MP0003787_abnormal_imprinting1.80910795
50MP0004885_abnormal_endolymph1.74342630
51MP0003633_abnormal_nervous_system1.71344428
52MP0004947_skin_inflammation1.68943181
53MP0008260_abnormal_autophagy1.68436068
54MP0000716_abnormal_immune_system1.67732640
55MP0009785_altered_susceptibility_to1.62431161
56MP0004924_abnormal_behavior1.61506674
57MP0005386_behavior/neurological_phenoty1.61506674
58MP0002822_catalepsy1.56023825
59MP0000703_abnormal_thymus_morphology1.55186279
60MP0003300_gastrointestinal_ulcer1.52059768
61MP0000920_abnormal_myelination1.51508906
62MP0002557_abnormal_social/conspecific_i1.50656381
63MP0003866_abnormal_defecation1.49765112
64MP0002396_abnormal_hematopoietic_system1.48872346
65* MP0002066_abnormal_motor_capabilities/c1.45563988
66MP0003690_abnormal_glial_cell1.44239505
67MP0002882_abnormal_neuron_morphology1.42194657
68MP0005310_abnormal_salivary_gland1.40287834
69MP0005646_abnormal_pituitary_gland1.38559686
70MP0002722_abnormal_immune_system1.38225626
71MP0009333_abnormal_splenocyte_physiolog1.38101229
72MP0002229_neurodegeneration1.37637097
73MP0003631_nervous_system_phenotype1.35846064
74MP0002405_respiratory_system_inflammati1.34396846
75MP0000689_abnormal_spleen_morphology1.33593720
76MP0006082_CNS_inflammation1.29009990
77MP0003879_abnormal_hair_cell1.27961487
78MP0000778_abnormal_nervous_system1.26272477
79MP0000569_abnormal_digit_pigmentation1.25770792
80MP0002429_abnormal_blood_cell1.25520702
81MP0008961_abnormal_basal_metabolism1.23669231
82MP0001984_abnormal_olfaction1.21812254
83MP0004145_abnormal_muscle_electrophysio1.21797167
84MP0001502_abnormal_circadian_rhythm1.21663000
85MP0005464_abnormal_platelet_physiology1.20685662
86MP0010155_abnormal_intestine_physiology1.17838515
87MP0005645_abnormal_hypothalamus_physiol1.17718174
88MP0002148_abnormal_hypersensitivity_rea1.16096835
89MP0003122_maternal_imprinting1.15764979
90MP0009278_abnormal_bone_marrow1.14400374
91MP0003172_abnormal_lysosome_physiology1.13736864
92MP0003634_abnormal_glial_cell1.10520153
93MP0009780_abnormal_chondrocyte_physiolo1.10179593
94MP0001845_abnormal_inflammatory_respons1.10148554
95MP0008872_abnormal_physiological_respon1.08407984
96MP0005166_decreased_susceptibility_to1.08374391
97MP0004130_abnormal_muscle_cell1.06091836
98MP0001533_abnormal_skeleton_physiology1.05287867
99MP0000751_myopathy1.04470589
100MP0004147_increased_porphyrin_level0.96782366
101MP0008874_decreased_physiological_sensi0.96647320
102MP0004742_abnormal_vestibular_system0.96426261
103MP0003632_abnormal_nervous_system0.95882054
104MP0001851_eye_inflammation0.94239555
105MP0003191_abnormal_cellular_cholesterol0.91727258
106MP0003183_abnormal_peptide_metabolism0.90977506
107MP0001963_abnormal_hearing_physiology0.90109276
108MP0004381_abnormal_hair_follicle0.88544930
109MP0000604_amyloidosis0.87365924
110MP0002006_tumorigenesis0.86775309
111MP0002152_abnormal_brain_morphology0.86058979
112MP0001485_abnormal_pinna_reflex0.85392655
113MP0001853_heart_inflammation0.85059290
114MP0005623_abnormal_meninges_morphology0.84755523
115MP0001986_abnormal_taste_sensitivity0.84081439
116MP0005394_taste/olfaction_phenotype0.83939012
117MP0005499_abnormal_olfactory_system0.83939012
118MP0001299_abnormal_eye_distance/0.83479478
119MP0002752_abnormal_somatic_nervous0.83332401
120MP0002132_abnormal_respiratory_system0.82973917
121MP0001905_abnormal_dopamine_level0.80746415
122MP0005535_abnormal_body_temperature0.79973092
123MP0000858_altered_metastatic_potential0.78295741
124MP0003045_fibrosis0.77695935
125MP0005551_abnormal_eye_electrophysiolog0.77213280
126MP0005167_abnormal_blood-brain_barrier0.75789060
127MP0001348_abnormal_lacrimal_gland0.73983188
128MP0002166_altered_tumor_susceptibility0.73761757
129MP0002069_abnormal_eating/drinking_beha0.72817912
130MP0008469_abnormal_protein_level0.71841040
131MP0004484_altered_response_of0.71481697
132MP0002998_abnormal_bone_remodeling0.70855708
133MP0003075_altered_response_to0.70275717
134MP0001873_stomach_inflammation0.70036864
135MP0004043_abnormal_pH_regulation0.69354094
136MP0005397_hematopoietic_system_phenotyp0.68309850
137MP0001545_abnormal_hematopoietic_system0.68309850
138MP0000013_abnormal_adipose_tissue0.68106779
139MP0002933_joint_inflammation0.67991089
140MP0000465_gastrointestinal_hemorrhage0.65862710
141MP0000747_muscle_weakness0.64255647
142MP0003137_abnormal_impulse_conducting0.64219105
143MP0001177_atelectasis0.63877703
144MP0004085_abnormal_heartbeat0.63351073
145MP0004215_abnormal_myocardial_fiber0.60294951
146MP0003283_abnormal_digestive_organ0.59928901
147MP0004510_myositis0.59746518
148* MP0010769_abnormal_survival0.54672603
149MP0001943_abnormal_respiration0.53144988
150MP0001529_abnormal_vocalization0.51599924
151* MP0010768_mortality/aging0.50651013
152MP0003646_muscle_fatigue0.48840654
153* MP0003956_abnormal_body_size0.48226620
154* MP0010770_preweaning_lethality0.48134142
155* MP0002082_postnatal_lethality0.48134142
156MP0002638_abnormal_pupillary_reflex0.47146412

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.85436981
2Focal motor seizures (HP:0011153)6.81628771
3Febrile seizures (HP:0002373)5.51639355
4Action tremor (HP:0002345)5.45355532
5Focal seizures (HP:0007359)5.32238715
6Visual hallucinations (HP:0002367)5.05556987
7Progressive cerebellar ataxia (HP:0002073)4.93786006
8Atonic seizures (HP:0010819)4.89080770
9Eczematoid dermatitis (HP:0000976)4.38662946
10Ankle clonus (HP:0011448)3.96352958
11Absence seizures (HP:0002121)3.95572033
12Myositis (HP:0100614)3.95164183
13Epileptic encephalopathy (HP:0200134)3.91927621
14Generalized tonic-clonic seizures (HP:0002069)3.81641470
15Ventricular fibrillation (HP:0001663)3.77796661
16Optic neuritis (HP:0100653)3.74877067
17Retrobulbar optic neuritis (HP:0100654)3.74877067
18Panhypogammaglobulinemia (HP:0003139)3.72554894
19Agammaglobulinemia (HP:0004432)3.72455441
20Ulnar claw (HP:0001178)3.70818549
21Orchitis (HP:0100796)3.66685885
22Meningitis (HP:0001287)3.66623749
23Postural instability (HP:0002172)3.64964859
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.59844864
25Dialeptic seizures (HP:0011146)3.59728631
26Truncal ataxia (HP:0002078)3.43760472
27Hemiplegia (HP:0002301)3.41627967
28Depression (HP:0000716)3.34618474
29Recurrent fungal infections (HP:0002841)3.28130873
30Recurrent bacterial skin infections (HP:0005406)3.25812631
31Recurrent abscess formation (HP:0002722)3.21618836
32Scanning speech (HP:0002168)3.20678937
33Dysmetria (HP:0001310)3.20087459
34* Supranuclear gaze palsy (HP:0000605)3.17735063
35Dysdiadochokinesis (HP:0002075)3.17731261
36Encephalitis (HP:0002383)3.16267223
37Urinary urgency (HP:0000012)3.13877748
38Abnormal eating behavior (HP:0100738)3.12363856
39Gaze-evoked nystagmus (HP:0000640)3.10948739
40T lymphocytopenia (HP:0005403)3.10774249
41Obstructive sleep apnea (HP:0002870)3.07871963
42Intention tremor (HP:0002080)3.02141381
43Cellulitis (HP:0100658)3.02014096
44Urinary bladder sphincter dysfunction (HP:0002839)3.00691449
45Abnormality of the lower motor neuron (HP:0002366)3.00473932
46Recurrent cutaneous fungal infections (HP:0011370)2.94279002
47Chronic mucocutaneous candidiasis (HP:0002728)2.94279002
48Mediastinal lymphadenopathy (HP:0100721)2.93896793
49Abnormality of macrophages (HP:0004311)2.92077655
50Peripheral hypomyelination (HP:0007182)2.90248714
51Insomnia (HP:0100785)2.88757416
52Pheochromocytoma (HP:0002666)2.85932070
53Vasculitis (HP:0002633)2.85668600
54Impaired vibration sensation in the lower limbs (HP:0002166)2.84227486
55Recurrent viral infections (HP:0004429)2.84222356
56Increased IgE level (HP:0003212)2.83079917
57Abnormality of T cell number (HP:0011839)2.81171798
58Elevated erythrocyte sedimentation rate (HP:0003565)2.80464848
59Gastrointestinal stroma tumor (HP:0100723)2.79841807
60Spastic gait (HP:0002064)2.78125054
61Colitis (HP:0002583)2.76137266
62Neurofibrillary tangles (HP:0002185)2.71574997
63Mutism (HP:0002300)2.71437025
64Impaired smooth pursuit (HP:0007772)2.68591457
65Keratoconjunctivitis sicca (HP:0001097)2.66611106
66Poor eye contact (HP:0000817)2.65714238
67Bundle branch block (HP:0011710)2.63577943
68Onion bulb formation (HP:0003383)2.63573579
69Impaired social interactions (HP:0000735)2.63464543
70Abnormal social behavior (HP:0012433)2.63464543
71Status epilepticus (HP:0002133)2.62924728
72Gastrointestinal inflammation (HP:0004386)2.62053706
73Inflammation of the large intestine (HP:0002037)2.61582214
74Anxiety (HP:0000739)2.61422475
75Fatigue (HP:0012378)2.60357861
76Papilledema (HP:0001085)2.60031953
77Hemiparesis (HP:0001269)2.58872288
78Genetic anticipation (HP:0003743)2.55626461
79Chronic obstructive pulmonary disease (HP:0006510)2.55522662
80Obstructive lung disease (HP:0006536)2.55522662
81Progressive inability to walk (HP:0002505)2.53180427
82Recurrent skin infections (HP:0001581)2.51573214
83Bradykinesia (HP:0002067)2.49330010
84Insidious onset (HP:0003587)2.48428148
85Termporal pattern (HP:0011008)2.48428148
86Gastrointestinal infarctions (HP:0005244)2.46416235
87Spontaneous hematomas (HP:0007420)2.45398553
88Abnormality of T cells (HP:0002843)2.44224855
89Annular pancreas (HP:0001734)2.44016079
90Abnormality of ocular smooth pursuit (HP:0000617)2.43902994
91Hammertoe (HP:0001765)2.40644619
92Neuroendocrine neoplasm (HP:0100634)2.40085433
93Stomatitis (HP:0010280)2.39873445
94Broad-based gait (HP:0002136)2.39062696
95Granulocytopenia (HP:0001913)2.38183541
96Keratoconjunctivitis (HP:0001096)2.36841304
97Recurrent gram-negative bacterial infections (HP:0005420)2.36024783
98Recurrent bronchitis (HP:0002837)2.34165302
99Torticollis (HP:0000473)2.31081482
100Lymphopenia (HP:0001888)2.31044531
101Abnormality of binocular vision (HP:0011514)2.30529346
102Diplopia (HP:0000651)2.30529346
103Pulmonary infiltrates (HP:0002113)2.27806508
104Hyperacusis (HP:0010780)2.26571275
105Amblyopia (HP:0000646)2.26176142
106Lower limb muscle weakness (HP:0007340)2.25997130
107Dysmetric saccades (HP:0000641)2.25992758
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25026396
109Spinal canal stenosis (HP:0003416)2.23482645
110Pointed chin (HP:0000307)2.22888268
111Cerebral inclusion bodies (HP:0100314)2.22427046
112Segmental peripheral demyelination/remyelination (HP:0003481)2.21252317
113Papilloma (HP:0012740)2.20929821
114Verrucae (HP:0200043)2.20929821
115Cerebral hypomyelination (HP:0006808)2.20499947
116Tetraplegia (HP:0002445)2.19978998
117Failure to thrive in infancy (HP:0001531)2.19591805
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19171868
119Pulmonary embolism (HP:0002204)2.16954184
120Pustule (HP:0200039)2.15848656
121Postural tremor (HP:0002174)2.15136888
122Clonus (HP:0002169)2.15051152
123Neuronal loss in central nervous system (HP:0002529)2.14680593
124* Slow saccadic eye movements (HP:0000514)2.14259019
125Fetal akinesia sequence (HP:0001989)2.14227573
126Hemoptysis (HP:0002105)2.13631194
127Hypercortisolism (HP:0001578)2.12697821
128Abnormality of cells of the lymphoid lineage (HP:0012140)2.11684035
129Steppage gait (HP:0003376)2.09433731
130IgG deficiency (HP:0004315)2.08807812
131* Memory impairment (HP:0002354)2.05015855
132Foot dorsiflexor weakness (HP:0009027)2.04795012
133Abnormality of the corticospinal tract (HP:0002492)2.04712578
134Abnormal EKG (HP:0003115)2.03893477
135Decreased motor nerve conduction velocity (HP:0003431)2.03195669
136Chest pain (HP:0100749)2.03085574
137Elfin facies (HP:0004428)2.02628437
138Gingivitis (HP:0000230)2.01397183
139Impaired vibratory sensation (HP:0002495)2.00685441
140Leukocytosis (HP:0001974)2.00339764
141Rigidity (HP:0002063)1.99860810
142Eosinophilia (HP:0001880)1.98747970
143Hypoplasia of the thymus (HP:0000778)1.97041915
144Megalencephaly (HP:0001355)1.95444416
145IgM deficiency (HP:0002850)1.95057865
146Osteomyelitis (HP:0002754)1.94780179
147Severe combined immunodeficiency (HP:0004430)1.94745597
148Gait ataxia (HP:0002066)1.93178930
149Distal sensory impairment (HP:0002936)1.93129747
150Abnormality of the fingertips (HP:0001211)1.92377125
151Increased IgM level (HP:0003496)1.92281480
152Focal dystonia (HP:0004373)1.91784018
153Rapidly progressive (HP:0003678)1.91017754
154Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.90277007
155Stereotypic behavior (HP:0000733)1.89384859
156Myotonia (HP:0002486)1.85127050
157Overriding aorta (HP:0002623)1.84962866
158Macroorchidism (HP:0000053)1.84448400
159Neoplasm of the heart (HP:0100544)1.83784162
160Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83625428
161Abnormality of the foot musculature (HP:0001436)1.83591883
162Increased circulating renin level (HP:0000848)1.82124333
163Craniofacial dystonia (HP:0012179)1.81797262
164Menstrual irregularities (HP:0000858)1.81768910
165Bradycardia (HP:0001662)1.80634068
166Resting tremor (HP:0002322)1.80152524
167Psychosis (HP:0000709)1.79844954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.51488353
2MAP3K93.65843537
3MAP4K13.55007945
4MINK13.34898224
5MAP3K43.15854053
6WNK12.96148575
7LMTK22.89025553
8MAP2K72.60351348
9MAP3K122.55473684
10STK382.49745197
11MAP2K42.45297072
12PAK62.26043855
13CAMKK12.24344203
14ERN12.20996812
15NTRK11.92822464
16GRK51.83131462
17KSR21.78717258
18TYK21.78369507
19BLK1.76295716
20NTRK21.74511937
21PINK11.70870938
22RIPK41.63462495
23TNK21.60441603
24PHKG11.60125023
25PHKG21.60125023
26SYK1.56946167
27MARK11.56147497
28TXK1.55934876
29PRKD31.55009184
30MAP2K31.51180955
31CDK191.47984546
32EPHA41.47313445
33CAMKK21.47171834
34UHMK11.45015600
35MAP3K111.30718303
36LATS21.28814229
37MAPK121.28535025
38SGK2231.27600929
39SGK4941.27600929
40CDK51.27155171
41TRIB31.26908728
42JAK31.26590393
43DAPK21.25877698
44IRAK41.25466259
45ZAP701.24531304
46BTK1.23282645
47PRKCH1.21677445
48MARK31.19045203
49MAP3K141.18978382
50ITK1.17934194
51FES1.17671402
52RET1.16831852
53GRK61.15897530
54MAPK131.15151502
55BMPR21.14506580
56CDK121.13158753
57MAP3K131.13009684
58SGK31.11537232
59CSK1.10807967
60SIK21.10457414
61JAK21.09112000
62MAP3K21.08845734
63HCK1.05888520
64SGK21.05284402
65PRKCG1.03558103
66ALK1.01010148
67FGFR41.00399099
68CAMK10.96183597
69LIMK10.95660265
70TNIK0.94950726
71IKBKE0.92658663
72STK110.91136606
73CDC42BPA0.90974841
74LCK0.88450330
75CAMK1G0.87306449
76TAOK10.83109137
77STK100.82638387
78TYRO30.81108801
79MAP3K10.80374621
80RIPK10.77340152
81SCYL20.77216444
82LYN0.76428571
83EPHB10.75012143
84ARAF0.74660340
85PLK20.73788891
86MARK20.73783268
87PDK10.72642872
88MAPK110.72182066
89MAPK70.71378125
90CAMK2G0.71272317
91TAOK20.70823115
92SMG10.69600869
93FGFR30.68928827
94BRSK10.68160527
95TBK10.68002428
96PRKCQ0.67672215
97MAP3K70.67385845
98PRKG20.66461278
99NEK10.66304637
100MAP3K100.64348311
101MAPK100.63100965
102GRK70.61752548
103PDPK10.60836148
104CSF1R0.60076237
105IRAK20.59541232
106FGR0.59445221
107CAMK2A0.58187601
108CDK150.58027477
109CDK180.57736851
110CAMK40.56678303
111TESK20.55675627
112OXSR10.55122827
113PNCK0.54457751
114PAK30.54261600
115STK390.53579123
116CDK140.52678805
117NEK60.52098438
118PRPF4B0.52049147
119SGK10.51320051
120PTK2B0.50457175
121KSR10.49885869
122ROCK20.49742225
123CDK11A0.48807097
124RPS6KA30.48445720
125HIPK20.48116824
126PIM10.48017246
127MAP3K30.47735863
128RAF10.46840959
129DAPK10.46353773
130TAOK30.46070471
131CAMK2B0.45933530
132DYRK1A0.45728155
133WNK40.44013901
134MAPKAPK50.41878722
135JAK10.41770732
136MUSK0.41650028
137PRKD20.41491386
138CAMK2D0.39202498
139PRKD10.38789191
140FYN0.38548210
141SIK30.36822431
142RPS6KA20.35883266
143ROCK10.35443054
144FER0.35186392
145CSNK1G20.34821721
146MAPK80.32407285
147MAP2K60.32159639

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.53330490
2Nicotine addiction_Homo sapiens_hsa050333.07743765
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.65381023
4Olfactory transduction_Homo sapiens_hsa047402.62863037
5Primary immunodeficiency_Homo sapiens_hsa053402.53674014
6GABAergic synapse_Homo sapiens_hsa047272.42463846
7Circadian entrainment_Homo sapiens_hsa047132.29286244
8Long-term potentiation_Homo sapiens_hsa047202.24732481
9Glutamatergic synapse_Homo sapiens_hsa047242.19582139
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15199453
11Salivary secretion_Homo sapiens_hsa049702.11793200
12Morphine addiction_Homo sapiens_hsa050322.05584935
13Gastric acid secretion_Homo sapiens_hsa049712.01286632
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.98875498
15Nitrogen metabolism_Homo sapiens_hsa009101.95349994
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94236316
17Insulin secretion_Homo sapiens_hsa049111.94094841
18Osteoclast differentiation_Homo sapiens_hsa043801.88381804
19Leishmaniasis_Homo sapiens_hsa051401.85803303
20Amphetamine addiction_Homo sapiens_hsa050311.83543178
21Dopaminergic synapse_Homo sapiens_hsa047281.80503781
22Taste transduction_Homo sapiens_hsa047421.79638037
23Graft-versus-host disease_Homo sapiens_hsa053321.72090975
24Allograft rejection_Homo sapiens_hsa053301.69887934
25Cholinergic synapse_Homo sapiens_hsa047251.69332115
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68675622
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68607978
28Autoimmune thyroid disease_Homo sapiens_hsa053201.61471478
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57801084
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56008992
31Long-term depression_Homo sapiens_hsa047301.45683129
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44486454
33GnRH signaling pathway_Homo sapiens_hsa049121.43355893
34Acute myeloid leukemia_Homo sapiens_hsa052211.42768135
35Calcium signaling pathway_Homo sapiens_hsa040201.41012836
36Oxytocin signaling pathway_Homo sapiens_hsa049211.40502180
37Renin secretion_Homo sapiens_hsa049241.40187321
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36009534
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.31774629
40Tuberculosis_Homo sapiens_hsa051521.31754833
41cAMP signaling pathway_Homo sapiens_hsa040241.30078497
42Serotonergic synapse_Homo sapiens_hsa047261.23642827
43Dorso-ventral axis formation_Homo sapiens_hsa043201.22171735
44Type II diabetes mellitus_Homo sapiens_hsa049301.20560161
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.17921197
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16643378
47Collecting duct acid secretion_Homo sapiens_hsa049661.13544629
48Staphylococcus aureus infection_Homo sapiens_hsa051501.12759627
49Measles_Homo sapiens_hsa051621.12199657
50Antigen processing and presentation_Homo sapiens_hsa046121.11711365
51Cocaine addiction_Homo sapiens_hsa050301.10658856
52Gap junction_Homo sapiens_hsa045401.09442102
53Toxoplasmosis_Homo sapiens_hsa051451.05398560
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02489723
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.01184797
56ErbB signaling pathway_Homo sapiens_hsa040121.00816256
57Glioma_Homo sapiens_hsa052140.99902318
58Estrogen signaling pathway_Homo sapiens_hsa049150.99883697
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97190651
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95440675
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.94156298
62Inositol phosphate metabolism_Homo sapiens_hsa005620.93394464
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91430681
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.90621201
65Viral myocarditis_Homo sapiens_hsa054160.90146646
66Influenza A_Homo sapiens_hsa051640.89512722
67Pancreatic secretion_Homo sapiens_hsa049720.89053847
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89005205
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87562913
70Hematopoietic cell lineage_Homo sapiens_hsa046400.86362270
71Chronic myeloid leukemia_Homo sapiens_hsa052200.86185234
72Hepatitis B_Homo sapiens_hsa051610.85072708
73Herpes simplex infection_Homo sapiens_hsa051680.84933923
74TNF signaling pathway_Homo sapiens_hsa046680.84001909
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83254671
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.82770601
77Choline metabolism in cancer_Homo sapiens_hsa052310.80427782
78Cardiac muscle contraction_Homo sapiens_hsa042600.80301664
79Asthma_Homo sapiens_hsa053100.79940407
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78643151
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.77772327
82Thyroid hormone synthesis_Homo sapiens_hsa049180.77081717
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76506153
84Melanogenesis_Homo sapiens_hsa049160.76060015
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75383681
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75089931
87MAPK signaling pathway_Homo sapiens_hsa040100.75087426
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74763089
89Renal cell carcinoma_Homo sapiens_hsa052110.74464121
90African trypanosomiasis_Homo sapiens_hsa051430.73086146
91Bile secretion_Homo sapiens_hsa049760.72383981
92Oocyte meiosis_Homo sapiens_hsa041140.71473410
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69498313
94Pancreatic cancer_Homo sapiens_hsa052120.69292756
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69207667
96Endocytosis_Homo sapiens_hsa041440.69156331
97Hepatitis C_Homo sapiens_hsa051600.65684146
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.64015887
99Dilated cardiomyopathy_Homo sapiens_hsa054140.63245494
100Vibrio cholerae infection_Homo sapiens_hsa051100.62717271
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62679527
102mTOR signaling pathway_Homo sapiens_hsa041500.62404726
103Axon guidance_Homo sapiens_hsa043600.62183830
104Epstein-Barr virus infection_Homo sapiens_hsa051690.61017628
105* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60914386
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.60376938
107Malaria_Homo sapiens_hsa051440.59025421
108Glucagon signaling pathway_Homo sapiens_hsa049220.58550637
109Apoptosis_Homo sapiens_hsa042100.58276507
110Insulin signaling pathway_Homo sapiens_hsa049100.57603844
111Rap1 signaling pathway_Homo sapiens_hsa040150.55809990
112VEGF signaling pathway_Homo sapiens_hsa043700.55355899
113Ras signaling pathway_Homo sapiens_hsa040140.54832646
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51695796
115Chemokine signaling pathway_Homo sapiens_hsa040620.51578816
116Endometrial cancer_Homo sapiens_hsa052130.49712632
117Non-small cell lung cancer_Homo sapiens_hsa052230.49223144
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47807014
119T cell receptor signaling pathway_Homo sapiens_hsa046600.46693910
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.46626724
121Circadian rhythm_Homo sapiens_hsa047100.45693403
122Phototransduction_Homo sapiens_hsa047440.45426626
123Salmonella infection_Homo sapiens_hsa051320.44069158
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40529558
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40408639
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39815056
127Type I diabetes mellitus_Homo sapiens_hsa049400.39145630
128Ovarian steroidogenesis_Homo sapiens_hsa049130.38559640
129Prolactin signaling pathway_Homo sapiens_hsa049170.38190308
130Platelet activation_Homo sapiens_hsa046110.36991173
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36862455
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35039194
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34816174
134Fatty acid biosynthesis_Homo sapiens_hsa000610.34809896
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.34136249
136B cell receptor signaling pathway_Homo sapiens_hsa046620.33362913
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32745155
138Mineral absorption_Homo sapiens_hsa049780.32218415

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