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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.86452916
2regulation of posttranscriptional gene silencing (GO:0060147)5.86452916
3regulation of gene silencing by miRNA (GO:0060964)5.86452916
4DNA unwinding involved in DNA replication (GO:0006268)4.94109697
5formation of translation preinitiation complex (GO:0001731)4.80151099
6DNA replication initiation (GO:0006270)4.67720043
7nucleobase biosynthetic process (GO:0046112)4.53331752
8regulation of SMAD protein import into nucleus (GO:0060390)4.42958892
9ribosome biogenesis (GO:0042254)4.40279305
10DNA strand elongation involved in DNA replication (GO:0006271)4.35262917
11DNA deamination (GO:0045006)4.34277869
12mitotic metaphase plate congression (GO:0007080)4.27610567
13maturation of SSU-rRNA (GO:0030490)4.27062466
14folic acid-containing compound biosynthetic process (GO:0009396)4.26125983
15IMP biosynthetic process (GO:0006188)4.22582149
16regulation of meiosis I (GO:0060631)4.17518429
17establishment of integrated proviral latency (GO:0075713)4.14419801
18ribosome assembly (GO:0042255)4.14358300
19purine nucleobase biosynthetic process (GO:0009113)4.12400089
20DNA strand elongation (GO:0022616)4.10827409
21apoptotic process involved in morphogenesis (GO:0060561)4.05367227
22regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.05208685
23regulation of helicase activity (GO:0051095)4.04234139
24DNA replication-dependent nucleosome organization (GO:0034723)4.02568676
25DNA replication-dependent nucleosome assembly (GO:0006335)4.02568676
26ribonucleoprotein complex biogenesis (GO:0022613)3.94549704
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.92696105
28histone arginine methylation (GO:0034969)3.92569774
29mitotic nuclear envelope disassembly (GO:0007077)3.85777720
30outer ear morphogenesis (GO:0042473)3.84427347
31nuclear pore organization (GO:0006999)3.82040854
32DNA replication checkpoint (GO:0000076)3.81575673
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80967428
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.80967428
35protein complex localization (GO:0031503)3.80220975
36ncRNA 3-end processing (GO:0043628)3.78196023
37telomere maintenance via semi-conservative replication (GO:0032201)3.76499286
38L-serine metabolic process (GO:0006563)3.68873550
39IMP metabolic process (GO:0046040)3.68079834
40regulation of histone H3-K9 methylation (GO:0051570)3.66018127
41cell migration involved in gastrulation (GO:0042074)3.65801623
42metaphase plate congression (GO:0051310)3.65118027
43cranial suture morphogenesis (GO:0060363)3.63672563
44peptidyl-arginine omega-N-methylation (GO:0035247)3.63632083
45cell fate commitment involved in formation of primary germ layer (GO:0060795)3.63501905
46ribosomal large subunit biogenesis (GO:0042273)3.62021665
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.60381400
48spliceosomal snRNP assembly (GO:0000387)3.59642203
49heterochromatin organization (GO:0070828)3.59201489
50negative regulation of mRNA processing (GO:0050686)3.58379209
51membrane disassembly (GO:0030397)3.57282380
52nuclear envelope disassembly (GO:0051081)3.57282380
53kinetochore assembly (GO:0051382)3.55865758
54paraxial mesoderm development (GO:0048339)3.55834005
55negative regulation of histone methylation (GO:0031061)3.54760404
56negative regulation of gene silencing (GO:0060969)3.50912419
57histone H4-K12 acetylation (GO:0043983)3.46329896
58ribosomal small subunit assembly (GO:0000028)3.45644361
59protein localization to kinetochore (GO:0034501)3.44551555
60kinetochore organization (GO:0051383)3.43545441
61regulation of glucocorticoid metabolic process (GO:0031943)3.42931293
62rRNA processing (GO:0006364)3.42296618
63viral transcription (GO:0019083)3.40730005
64pre-miRNA processing (GO:0031054)3.40661271
65regulation of mammary gland epithelial cell proliferation (GO:0033599)3.40336764
66morphogenesis of an epithelial fold (GO:0060571)3.39712774
67cellular protein complex localization (GO:0034629)3.39352576
68ribosomal small subunit biogenesis (GO:0042274)3.39295857
69translational initiation (GO:0006413)3.38769230
70chromatin remodeling at centromere (GO:0031055)3.37946128
71transcription from mitochondrial promoter (GO:0006390)3.37662229
72DNA duplex unwinding (GO:0032508)3.37028246
73translational termination (GO:0006415)3.36912105
74DNA geometric change (GO:0032392)3.36493810
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36423318
76negative regulation of RNA splicing (GO:0033119)3.33375678
77mitotic chromosome condensation (GO:0007076)3.32967944
78protein localization to chromosome, centromeric region (GO:0071459)3.32771370
79regulation of gene silencing (GO:0060968)3.32143820
80pentose metabolic process (GO:0019321)3.31742682
81regulation of stem cell maintenance (GO:2000036)3.31223536
82pseudouridine synthesis (GO:0001522)3.30647703
83rRNA metabolic process (GO:0016072)3.30553223
84telomere maintenance via telomere lengthening (GO:0010833)3.30430176
85ventricular trabecula myocardium morphogenesis (GO:0003222)3.28951565
86negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.27758928
87piRNA metabolic process (GO:0034587)3.26559414
88CENP-A containing nucleosome assembly (GO:0034080)3.24983811
89translational elongation (GO:0006414)3.23731167
90nuclear pore complex assembly (GO:0051292)3.23249478
91negative regulation of mRNA metabolic process (GO:1903312)3.21470622
92mitotic sister chromatid segregation (GO:0000070)3.21428330
93tooth mineralization (GO:0034505)3.18763310
94telomere maintenance via recombination (GO:0000722)3.17505503
95convergent extension (GO:0060026)3.15967058
96establishment of chromosome localization (GO:0051303)3.12650549
97positive regulation of SMAD protein import into nucleus (GO:0060391)3.12055197
98regulation of spindle organization (GO:0090224)3.11371849
99proteasome assembly (GO:0043248)3.07932264
100transcription-coupled nucleotide-excision repair (GO:0006283)3.07742408
101DNA replication-independent nucleosome organization (GO:0034724)3.06484332
102DNA replication-independent nucleosome assembly (GO:0006336)3.06484332
103viral life cycle (GO:0019058)3.06323763
104spliceosomal complex assembly (GO:0000245)3.05424545
105single strand break repair (GO:0000012)3.05354824
106peptidyl-arginine methylation (GO:0018216)3.04479197
107peptidyl-arginine N-methylation (GO:0035246)3.04479197
108nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04358070
109lung-associated mesenchyme development (GO:0060484)3.03749767
110regulation of activin receptor signaling pathway (GO:0032925)3.03395218
111regulation of timing of cell differentiation (GO:0048505)3.02812276
112regulation of cell fate specification (GO:0042659)3.02390072
113chaperone-mediated protein complex assembly (GO:0051131)3.01790765
114regulation of glucocorticoid secretion (GO:2000849)3.01734028
115mitotic recombination (GO:0006312)3.01520884
116chromatin assembly (GO:0031497)3.00873481
117folic acid metabolic process (GO:0046655)3.00196906
118rRNA modification (GO:0000154)2.99804541
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.98980248
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97891068
121regulation of chromatin silencing (GO:0031935)2.97502694
122establishment of viral latency (GO:0019043)2.97415449
123primitive streak formation (GO:0090009)2.96673854
124protein K6-linked ubiquitination (GO:0085020)2.96629845
125viral mRNA export from host cell nucleus (GO:0046784)2.96293204
126negative regulation of chromosome segregation (GO:0051985)2.95973318
127DNA damage response, detection of DNA damage (GO:0042769)2.95907555
128positive regulation of hair follicle development (GO:0051798)2.95743710
129positive regulation of hair cycle (GO:0042635)2.95743710
130tRNA aminoacylation for protein translation (GO:0006418)2.95636602
131gonadal mesoderm development (GO:0007506)2.94532205
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94472025
133regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.94194784
134nodal signaling pathway (GO:0038092)2.94072091
135determination of adult lifespan (GO:0008340)2.93457857
136establishment of protein localization to mitochondrial membrane (GO:0090151)2.93018971
137regulation of mitotic spindle organization (GO:0060236)2.92239358
138maturation of 5.8S rRNA (GO:0000460)2.91882210
139histone exchange (GO:0043486)2.90967477
140positive regulation of catenin import into nucleus (GO:0035413)2.90302224
141regulation of translational termination (GO:0006449)2.89735446
142histone H2A acetylation (GO:0043968)2.89710646
143regulation of development, heterochronic (GO:0040034)2.88644148
144regulation of mitochondrial translation (GO:0070129)2.87925874
145negative regulation of androgen receptor signaling pathway (GO:0060766)2.87541904
146negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86451274
147negative regulation of sister chromatid segregation (GO:0033046)2.86451274
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.86451274
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86451274
150protein maturation by protein folding (GO:0022417)2.85714301
151cotranslational protein targeting to membrane (GO:0006613)2.83682398
152protein targeting to ER (GO:0045047)2.83635725
153proline biosynthetic process (GO:0006561)2.83438423
154cellular protein complex disassembly (GO:0043624)2.80436699
155apoptotic process involved in development (GO:1902742)2.80402598
156regulation of hair follicle development (GO:0051797)2.80213332
157embryonic process involved in female pregnancy (GO:0060136)2.76451989
158negative regulation of norepinephrine secretion (GO:0010700)2.75184035
159positive regulation of chromosome segregation (GO:0051984)2.74952016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.44338694
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51247434
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.53185225
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.36082939
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26920158
6* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98875106
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95974525
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.94906515
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.94906515
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.94906515
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83231204
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68567690
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66430827
14* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.64703791
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.61833712
16* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.52432925
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.52083555
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45406239
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.43561585
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37397479
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27824566
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25891425
23XRN2_22483619_ChIP-Seq_HELA_Human2.22858573
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22033991
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13371937
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12464203
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.11867424
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.10785822
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08024109
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05016490
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04598573
32* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.98200035
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.97443140
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96353888
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90092667
36AR_21909140_ChIP-Seq_LNCAP_Human1.82889864
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82166809
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.79301477
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76569553
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76396194
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.74014427
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73921823
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73459081
44VDR_23849224_ChIP-Seq_CD4+_Human1.71460079
45VDR_21846776_ChIP-Seq_THP-1_Human1.68356472
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.66482411
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.63102870
48* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62937136
49TTF2_22483619_ChIP-Seq_HELA_Human1.62547111
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61048556
51DCP1A_22483619_ChIP-Seq_HELA_Human1.54048492
52GABP_19822575_ChIP-Seq_HepG2_Human1.52892791
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52779139
54FOXP3_21729870_ChIP-Seq_TREG_Human1.52331434
55* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.48105356
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46942255
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46079043
58* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.44326784
59LXR_22292898_ChIP-Seq_THP-1_Human1.42911404
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42879347
61* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40608695
62* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39261434
63* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39132798
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38874645
65* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38337213
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37081791
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36174706
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35856412
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35152026
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.34828587
71CIITA_25753668_ChIP-Seq_RAJI_Human1.34699307
72* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32908180
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32682980
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31207140
75* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30976879
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.29146895
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28469698
78KDM5A_27292631_Chip-Seq_BREAST_Human1.27341117
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26760086
80* P68_20966046_ChIP-Seq_HELA_Human1.26260437
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26020562
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.24947818
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24132789
84MYC_22102868_ChIP-Seq_BL_Human1.22984888
85* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22712883
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22225528
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22195594
88* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.21987562
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20336101
90POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18586347
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.16835356
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16011023
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.15912985
94ZNF263_19887448_ChIP-Seq_K562_Human1.15618446
95* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14152324
96SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12860893
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.11646143
98FOXP1_21924763_ChIP-Seq_HESCs_Human1.11577473
99* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.10997554
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10541521
101* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10347350
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.09151567
103TFEB_21752829_ChIP-Seq_HELA_Human1.08169913
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08103446
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07972020
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07345493
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06702508
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.04783666
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04710670
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03558831
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.03032536
112* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02804775
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99536223
114ELK1_19687146_ChIP-ChIP_HELA_Human0.98756696
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98012167
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.97575359
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94778728
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92301788
119* KAP1_27257070_Chip-Seq_ESCs_Mouse0.92172414
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.91651840
121SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91319405
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90990933
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90515952
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88596920
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86375388
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84944822
127* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.83738047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.05926819
2MP0004957_abnormal_blastocyst_morpholog4.74180255
3MP0002163_abnormal_gland_morphology4.68724876
4MP0003111_abnormal_nucleus_morphology4.41687361
5MP0010094_abnormal_chromosome_stability4.03586983
6MP0002254_reproductive_system_inflammat3.84247087
7MP0003077_abnormal_cell_cycle3.72817994
8MP0008057_abnormal_DNA_replication3.62972957
9MP0004133_heterotaxia3.16869875
10MP0004858_abnormal_nervous_system3.12303469
11MP0008058_abnormal_DNA_repair3.08422147
12MP0003806_abnormal_nucleotide_metabolis3.07831475
13MP0008877_abnormal_DNA_methylation3.03031425
14MP0005379_endocrine/exocrine_gland_phen2.91266494
15MP0010352_gastrointestinal_tract_polyps2.77950056
16MP0001346_abnormal_lacrimal_gland2.77097446
17MP0001730_embryonic_growth_arrest2.74635925
18MP0008932_abnormal_embryonic_tissue2.57918906
19MP0002653_abnormal_ependyma_morphology2.57102810
20MP0003123_paternal_imprinting2.51822056
21MP0000350_abnormal_cell_proliferation2.46120552
22MP0008007_abnormal_cellular_replicative2.38794733
23MP0005623_abnormal_meninges_morphology2.12968338
24MP0003890_abnormal_embryonic-extraembry2.12183023
25MP0003718_maternal_effect2.09840733
26MP0005380_embryogenesis_phenotype2.06115518
27MP0001672_abnormal_embryogenesis/_devel2.06115518
28MP0003119_abnormal_digestive_system2.05665709
29MP0001697_abnormal_embryo_size1.99018460
30MP0003941_abnormal_skin_development1.98054917
31MP0002085_abnormal_embryonic_tissue1.97381287
32MP0010030_abnormal_orbit_morphology1.90986565
33MP0002084_abnormal_developmental_patter1.85641088
34MP0003283_abnormal_digestive_organ1.82009098
35MP0000566_synostosis1.79764330
36MP0003984_embryonic_growth_retardation1.76674430
37MP0001293_anophthalmia1.76615127
38MP0002088_abnormal_embryonic_growth/wei1.74274345
39MP0006292_abnormal_olfactory_placode1.72362317
40MP0003786_premature_aging1.72324551
41MP0004197_abnormal_fetal_growth/weight/1.69413583
42MP0002080_prenatal_lethality1.69143535
43MP0002086_abnormal_extraembryonic_tissu1.60636396
44MP0010307_abnormal_tumor_latency1.60010295
45MP0009278_abnormal_bone_marrow1.57551409
46MP0000678_abnormal_parathyroid_gland1.53186342
47MP0003567_abnormal_fetal_cardiomyocyte1.51817065
48MP0004185_abnormal_adipocyte_glucose1.47871530
49MP0003315_abnormal_perineum_morphology1.42838571
50MP0002089_abnormal_postnatal_growth/wei1.40936592
51MP0000537_abnormal_urethra_morphology1.40728305
52MP0010368_abnormal_lymphatic_system1.38474075
53MP0003136_yellow_coat_color1.37402877
54MP0000313_abnormal_cell_death1.36059483
55MP0002210_abnormal_sex_determination1.34062945
56MP0005367_renal/urinary_system_phenotyp1.26566755
57MP0000516_abnormal_urinary_system1.26566755
58MP0001145_abnormal_male_reproductive1.23206015
59MP0003186_abnormal_redox_activity1.21201593
60MP0005076_abnormal_cell_differentiation1.19679178
61MP0001849_ear_inflammation1.15744227
62MP0009053_abnormal_anal_canal1.12876550
63MP0002111_abnormal_tail_morphology1.09620861
64MP0009672_abnormal_birth_weight1.09394093
65MP0002160_abnormal_reproductive_system1.09313205
66MP0002019_abnormal_tumor_incidence1.09138095
67MP0005647_abnormal_sex_gland1.08755979
68MP0001188_hyperpigmentation1.07377787
69MP0003121_genomic_imprinting1.05382481
70MP0000653_abnormal_sex_gland1.01128469
71MP0005646_abnormal_pituitary_gland1.00868655
72MP0008260_abnormal_autophagy1.00388692
73MP0000490_abnormal_crypts_of0.98655416
74MP0001929_abnormal_gametogenesis0.97206622
75MP0001286_abnormal_eye_development0.94461681
76MP0009703_decreased_birth_body0.92065840
77MP0010630_abnormal_cardiac_muscle0.91632244
78MP0000462_abnormal_digestive_system0.90507502
79MP0005666_abnormal_adipose_tissue0.90503846
80MP0003878_abnormal_ear_physiology0.89882809
81MP0005377_hearing/vestibular/ear_phenot0.89882809
82MP0009333_abnormal_splenocyte_physiolog0.88314756
83MP0005501_abnormal_skin_physiology0.88062712
84MP0003935_abnormal_craniofacial_develop0.87923128
85MP0009379_abnormal_foot_pigmentation0.87117303
86MP0003861_abnormal_nervous_system0.84709177
87MP0003942_abnormal_urinary_system0.84519315
88MP0003566_abnormal_cell_adhesion0.83832145
89MP0005266_abnormal_metabolism0.83134930
90MP0000358_abnormal_cell_content/0.81360550
91MP0002697_abnormal_eye_size0.80536428
92MP0003936_abnormal_reproductive_system0.79612402
93MP0002932_abnormal_joint_morphology0.79588066
94MP0005389_reproductive_system_phenotype0.78622002
95MP0003705_abnormal_hypodermis_morpholog0.77106556
96MP0000858_altered_metastatic_potential0.77019904
97MP0000432_abnormal_head_morphology0.76541382
98MP0001661_extended_life_span0.75023733
99MP0008789_abnormal_olfactory_epithelium0.74252372
100MP0003699_abnormal_female_reproductive0.73689420
101MP0003937_abnormal_limbs/digits/tail_de0.72795561
102MP0002751_abnormal_autonomic_nervous0.71585772
103MP0005023_abnormal_wound_healing0.71508793
104MP0005384_cellular_phenotype0.70348920
105MP0002114_abnormal_axial_skeleton0.70259014
106MP0001119_abnormal_female_reproductive0.70125109
107MP0000750_abnormal_muscle_regeneration0.69453066
108MP0001348_abnormal_lacrimal_gland0.69445621
109MP0005257_abnormal_intraocular_pressure0.69355978
110MP0009250_abnormal_appendicular_skeleto0.67068761
111MP0005375_adipose_tissue_phenotype0.67061723
112MP0002092_abnormal_eye_morphology0.66779873
113MP0003453_abnormal_keratinocyte_physiol0.66571431
114MP0005395_other_phenotype0.66504928
115MP0002234_abnormal_pharynx_morphology0.65505511
116MP0005621_abnormal_cell_physiology0.64199942
117MP0002796_impaired_skin_barrier0.61487683
118MP0001919_abnormal_reproductive_system0.61231043
119MP0006035_abnormal_mitochondrial_morpho0.60632697
120MP0000477_abnormal_intestine_morphology0.60221985
121MP0003698_abnormal_male_reproductive0.60168049
122MP0008770_decreased_survivor_rate0.60116566
123MP0001915_intracranial_hemorrhage0.60044207
124MP0002249_abnormal_larynx_morphology0.59589817
125MP0002396_abnormal_hematopoietic_system0.59146103
126MP0000049_abnormal_middle_ear0.56826401
127MP0002161_abnormal_fertility/fecundity0.56704819
128MP0002127_abnormal_cardiovascular_syste0.54859310
129MP0005394_taste/olfaction_phenotype0.53705401
130MP0005499_abnormal_olfactory_system0.53705401
131MP0002269_muscular_atrophy0.53194836
132MP0004233_abnormal_muscle_weight0.52771787
133MP0000428_abnormal_craniofacial_morphol0.52674104
134MP0005670_abnormal_white_adipose0.52133119
135MP0000470_abnormal_stomach_morphology0.51851885

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.01366689
2Breast hypoplasia (HP:0003187)4.69762639
3Ependymoma (HP:0002888)4.49819505
4Abnormality of the anterior horn cell (HP:0006802)4.34428454
5Degeneration of anterior horn cells (HP:0002398)4.34428454
6Colon cancer (HP:0003003)4.03848943
7Supernumerary spleens (HP:0009799)3.98588735
8Abnormal ventriculo-arterial connection (HP:0011563)3.94102548
9Transposition of the great arteries (HP:0001669)3.94102548
10Abnormal connection of the cardiac segments (HP:0011545)3.94102548
11Carpal bone hypoplasia (HP:0001498)3.89046992
12Broad distal phalanx of finger (HP:0009836)3.77123952
13Selective tooth agenesis (HP:0001592)3.75020485
14Bilateral microphthalmos (HP:0007633)3.72471886
15Absent radius (HP:0003974)3.71966662
16Medulloblastoma (HP:0002885)3.58970094
17Oral leukoplakia (HP:0002745)3.58351453
18Aplasia involving forearm bones (HP:0009822)3.49578399
19Absent forearm bone (HP:0003953)3.49578399
20Abnormality of the labia minora (HP:0012880)3.45686056
21Patellar aplasia (HP:0006443)3.23959556
22Abnormality of abdominal situs (HP:0011620)3.23697518
23Abdominal situs inversus (HP:0003363)3.23697518
24Agnosia (HP:0010524)3.22116766
25Reticulocytopenia (HP:0001896)3.18584986
26Absent thumb (HP:0009777)3.18087143
27Abnormality of the aortic arch (HP:0012303)3.12231470
28Asplenia (HP:0001746)3.08848130
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.07544538
30Delayed epiphyseal ossification (HP:0002663)3.07109421
31Neoplasm of the oral cavity (HP:0100649)3.01622571
32Hyperglycinuria (HP:0003108)2.99948124
33Rhabdomyosarcoma (HP:0002859)2.99691880
34Aplasia/hypoplasia of the humerus (HP:0006507)2.98307578
35Cerebral hypomyelination (HP:0006808)2.98200856
36Trismus (HP:0000211)2.98166637
37Rough bone trabeculation (HP:0100670)2.98021384
38Aplasia/Hypoplasia of the patella (HP:0006498)2.96955686
39Astrocytoma (HP:0009592)2.94297728
40Abnormality of the astrocytes (HP:0100707)2.94297728
41Progressive muscle weakness (HP:0003323)2.94105769
42Esophageal atresia (HP:0002032)2.90757985
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.85008488
44Abnormal number of incisors (HP:0011064)2.83150413
45Stenosis of the external auditory canal (HP:0000402)2.79522698
46Partial duplication of the phalanx of hand (HP:0009999)2.72202002
47Impulsivity (HP:0100710)2.71358167
48Rib fusion (HP:0000902)2.70943338
49Rectovaginal fistula (HP:0000143)2.69319216
50Rectal fistula (HP:0100590)2.69319216
51Short middle phalanx of the 5th finger (HP:0004220)2.66390178
52Horseshoe kidney (HP:0000085)2.63865137
53Atrophy/Degeneration involving motor neurons (HP:0007373)2.63578998
54Partial duplication of thumb phalanx (HP:0009944)2.62424001
55Glioma (HP:0009733)2.60670217
56Short humerus (HP:0005792)2.56380829
57Biliary tract neoplasm (HP:0100574)2.54715477
58Neoplasm of the pancreas (HP:0002894)2.54122918
59Abnormality of pyrimidine metabolism (HP:0004353)2.53588295
60Chromsome breakage (HP:0040012)2.52442578
61Abnormality of the middle phalanges of the toes (HP:0010183)2.50699428
62Neoplasm of striated muscle (HP:0009728)2.48317996
63Shawl scrotum (HP:0000049)2.48098766
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47113976
65Basal cell carcinoma (HP:0002671)2.45755884
66Duplication of thumb phalanx (HP:0009942)2.40531244
67Thrombocytosis (HP:0001894)2.39275734
68Choanal stenosis (HP:0000452)2.38206359
69Cellular immunodeficiency (HP:0005374)2.35111188
70Intestinal fistula (HP:0100819)2.33667661
71Abnormality of cells of the erythroid lineage (HP:0012130)2.33318918
72Premature ovarian failure (HP:0008209)2.33136607
73Missing ribs (HP:0000921)2.32862411
74Tracheoesophageal fistula (HP:0002575)2.32450837
75Metaphyseal cupping (HP:0003021)2.29701534
76Facial cleft (HP:0002006)2.28240885
77Abnormality of the phalanges of the hallux (HP:0010057)2.28077663
78Supernumerary bones of the axial skeleton (HP:0009144)2.26665825
79Abnormality of the salivary glands (HP:0010286)2.26311891
80Septate vagina (HP:0001153)2.25562372
81Single umbilical artery (HP:0001195)2.25282541
82Abnormality of the fetal cardiovascular system (HP:0010948)2.25282541
83Abnormal umbilical cord blood vessels (HP:0011403)2.25282541
84Adenoma sebaceum (HP:0009720)2.23457654
85Angiofibromas (HP:0010615)2.23457654
86Myopathic facies (HP:0002058)2.23249749
87Meckel diverticulum (HP:0002245)2.23145889
88Vaginal fistula (HP:0004320)2.22655795
89Osteomalacia (HP:0002749)2.22142230
90Premature graying of hair (HP:0002216)2.21157462
91High anterior hairline (HP:0009890)2.20999586
92Breast aplasia (HP:0100783)2.20065750
93Fused cervical vertebrae (HP:0002949)2.18681686
94Abnormal trabecular bone morphology (HP:0100671)2.17866490
95Abnormal sex determination (HP:0012244)2.17482441
96Sex reversal (HP:0012245)2.17482441
97Anal stenosis (HP:0002025)2.17168712
98Truncus arteriosus (HP:0001660)2.16963830
99Gastrointestinal atresia (HP:0002589)2.16423475
100Abnormality of the preputium (HP:0100587)2.15768954
101Atresia of the external auditory canal (HP:0000413)2.15717619
102Broad thumb (HP:0011304)2.15499556
103Abnormality of the ileum (HP:0001549)2.14608906
104Macrocytic anemia (HP:0001972)2.14264692
105Pseudobulbar signs (HP:0002200)2.13636859
106Hypoplastic left heart (HP:0004383)2.13610793
107Septo-optic dysplasia (HP:0100842)2.11679538
108Aplasia/Hypoplasia of the macula (HP:0008059)2.09694493
109Intestinal atresia (HP:0011100)2.09125413
110Turricephaly (HP:0000262)2.09085530
111Squamous cell carcinoma (HP:0002860)2.07662740
112Microvesicular hepatic steatosis (HP:0001414)2.07345290
113Cleft eyelid (HP:0000625)2.06857020
114Multiple enchondromatosis (HP:0005701)2.06283709
115Hypoplasia of the radius (HP:0002984)2.06162433
116Aplasia/Hypoplasia of the breasts (HP:0010311)2.05588593
117Spinal muscular atrophy (HP:0007269)2.04109307
118Proximal placement of thumb (HP:0009623)2.03775225
119Vertebral fusion (HP:0002948)2.01848026
120Diastasis recti (HP:0001540)1.99796022
121Stridor (HP:0010307)1.99584425
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.99538365
123Supernumerary ribs (HP:0005815)1.99524731
124Congenital malformation of the right heart (HP:0011723)1.99240898
125Double outlet right ventricle (HP:0001719)1.99240898
126Renal agenesis (HP:0000104)1.98845020
127Long palpebral fissure (HP:0000637)1.97524253
128Abnormal lung lobation (HP:0002101)1.97157956
129Ectopic kidney (HP:0000086)1.96727782
130Neoplasm of the colon (HP:0100273)1.92017280
131Tongue fasciculations (HP:0001308)1.91986070
132Triphalangeal thumb (HP:0001199)1.91484952
133Abnormality of chromosome stability (HP:0003220)1.90531339
134Microretrognathia (HP:0000308)1.90064231
135Deviation of the thumb (HP:0009603)1.88615592
136Aplasia/Hypoplasia affecting the retina (HP:0008061)1.88080490
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86918120
138Optic nerve coloboma (HP:0000588)1.86448001
139Broad phalanges of the hand (HP:0009768)1.85996437
140Abnormal number of erythroid precursors (HP:0012131)1.85955939
141Hemivertebrae (HP:0002937)1.85577649
142Carpal synostosis (HP:0009702)1.85108781
143Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84509336
144Abnormality of serine family amino acid metabolism (HP:0010894)1.84431352
145Abnormality of glycine metabolism (HP:0010895)1.84431352
146Preaxial foot polydactyly (HP:0001841)1.83891222
147Gout (HP:0001997)1.80541231
148Persistence of primary teeth (HP:0006335)1.78782336
149Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76331925
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76331925
151Dysphonia (HP:0001618)1.72799002
152Ulnar bowing (HP:0003031)1.72526699
153Genu recurvatum (HP:0002816)1.72444708
154Broad finger (HP:0001500)1.70516958
155Testicular atrophy (HP:0000029)1.67513012
156Acute lymphatic leukemia (HP:0006721)1.65982115
157Coronal craniosynostosis (HP:0004440)1.63693692
158Hepatoblastoma (HP:0002884)1.63269337
159External ophthalmoplegia (HP:0000544)1.61230267
160Maternal diabetes (HP:0009800)1.60757430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.27052037
2CDK194.89666665
3SMG14.64801827
4CDC74.32676990
5WEE14.14340468
6VRK24.12826340
7EPHA23.14970151
8CDK122.85479079
9LMTK22.79946927
10EIF2AK12.76865175
11TTK2.67870099
12NEK12.53336089
13TSSK62.43164474
14SRPK12.30086571
15NEK22.28818454
16PNCK2.24452956
17CDK72.13426521
18PLK12.08921374
19MKNK11.89014361
20TAF11.86733053
21RPS6KB21.83369328
22TESK21.80374892
23PLK41.75155798
24AURKA1.65178278
25ATR1.58024466
26BMX1.50398797
27PLK31.50048413
28MKNK21.49612674
29CHEK21.49447407
30PASK1.48098354
31STK38L1.45061988
32BRD41.44420213
33PRPF4B1.43921408
34AURKB1.43673074
35SCYL21.43051645
36DYRK31.38162905
37MAP3K81.37989420
38ACVR1B1.37621012
39EIF2AK31.35253045
40NME21.32657024
41PAK41.31299762
42CHEK11.28253593
43CDK81.25610920
44CSNK1G31.23262556
45CDK41.22145327
46FLT31.21740393
47PHKG11.21209152
48PHKG21.21209152
49CSNK1G21.18761385
50BCKDK1.17197034
51VRK11.17144711
52RPS6KA41.16444538
53TLK11.15728162
54STK101.14819880
55AKT31.12367587
56ALK1.12229394
57LATS21.10250285
58CDK21.04153469
59CSNK1G11.03932130
60TAOK21.03526270
61PRKCI1.02897332
62STK40.98675816
63ARAF0.97798775
64CSNK1A1L0.97015673
65BRSK20.94478957
66ATM0.92313694
67CSNK2A20.88469476
68MAPKAPK30.88456307
69PRKG20.81582002
70CSNK1E0.80005957
71MAP3K100.79810375
72STK160.79032990
73DYRK20.75539793
74CSNK2A10.73916626
75RPS6KA20.72510857
76PAK10.72452671
77RPS6KC10.72159217
78RPS6KL10.72159217
79BRAF0.71285390
80MTOR0.70563875
81MET0.69018049
82CDK90.68987209
83MELK0.68852399
84PIM10.67973338
85CDK10.67859695
86DMPK0.67624469
87MAP4K10.62335008
88PKN20.61481130
89ILK0.61293059
90ICK0.59362372
91FGFR10.59073409
92ZAK0.58809610
93KDR0.58773107
94CAMK1G0.58770850
95RPS6KA60.58687042
96TGFBR10.57944931
97GRK60.57079289
98MAP3K110.56627226
99AKT20.53924350
100BRSK10.53902174
101CDK11A0.53677679
102FGFR40.53153381
103PBK0.53140614
104PDK20.53100124
105ERBB40.52752133
106CDK60.51223063
107PDK30.49090640
108PDK40.49090640
109PRKDC0.46959417
110STK240.46383007
111MST40.45925506
112TESK10.45353612
113KSR20.44809517
114MAP3K10.43399196
115LRRK20.42969360
116EIF2AK20.40424431
117CSNK1D0.40290092
118MAP3K130.38902663
119MAPKAPK50.37936533
120RPS6KA50.37920306
121MAP2K20.36374814
122TAOK10.35914016
123OXSR10.34487659
124MAPK140.34105118
125TYRO30.31698734
126GSK3B0.31328392
127DAPK10.30748993
128CDK150.27613823
129TRIB30.26590820
130MAP3K90.26447480
131MAPK10.25986147
132LATS10.25616391
133MAPK100.24998243
134AKT10.24471972
135NME10.22421439
136RPS6KA10.22292806
137EEF2K0.21749005
138DAPK30.21663986

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.73088713
2Mismatch repair_Homo sapiens_hsa034304.51842474
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.19852996
4RNA polymerase_Homo sapiens_hsa030203.64333761
5Spliceosome_Homo sapiens_hsa030403.61648423
6Ribosome_Homo sapiens_hsa030103.50455170
7RNA transport_Homo sapiens_hsa030133.46453211
8Proteasome_Homo sapiens_hsa030503.21784161
9One carbon pool by folate_Homo sapiens_hsa006703.21465967
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.11382345
11Base excision repair_Homo sapiens_hsa034102.85249981
12Homologous recombination_Homo sapiens_hsa034402.76984505
13Nucleotide excision repair_Homo sapiens_hsa034202.72885582
14Pyrimidine metabolism_Homo sapiens_hsa002402.42531354
15Cell cycle_Homo sapiens_hsa041102.34289354
16Fanconi anemia pathway_Homo sapiens_hsa034602.03829264
17mRNA surveillance pathway_Homo sapiens_hsa030152.00640943
18RNA degradation_Homo sapiens_hsa030181.88895816
19Non-homologous end-joining_Homo sapiens_hsa034501.82702773
20Basal transcription factors_Homo sapiens_hsa030221.78253105
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71833383
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.57204224
23Oxidative phosphorylation_Homo sapiens_hsa001901.52508474
24p53 signaling pathway_Homo sapiens_hsa041151.44313241
25Biosynthesis of amino acids_Homo sapiens_hsa012301.31506168
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.21069166
27Purine metabolism_Homo sapiens_hsa002301.20424849
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10982190
29Folate biosynthesis_Homo sapiens_hsa007901.10645600
30Selenocompound metabolism_Homo sapiens_hsa004501.09379865
31Fatty acid elongation_Homo sapiens_hsa000621.06919860
32Epstein-Barr virus infection_Homo sapiens_hsa051691.06832926
33Oocyte meiosis_Homo sapiens_hsa041141.05108660
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03725746
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98797949
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90425481
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87016026
38Thyroid cancer_Homo sapiens_hsa052160.83773953
39Basal cell carcinoma_Homo sapiens_hsa052170.82088217
40Hippo signaling pathway_Homo sapiens_hsa043900.78806214
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78292025
42Sulfur relay system_Homo sapiens_hsa041220.75097141
43Carbon metabolism_Homo sapiens_hsa012000.74799729
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74044493
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73612433
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72338485
47Alzheimers disease_Homo sapiens_hsa050100.71770457
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70559346
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70245326
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69668603
51Glutathione metabolism_Homo sapiens_hsa004800.68848829
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.68391663
53Viral carcinogenesis_Homo sapiens_hsa052030.64854231
54Fructose and mannose metabolism_Homo sapiens_hsa000510.64002277
55TGF-beta signaling pathway_Homo sapiens_hsa043500.63139162
56Huntingtons disease_Homo sapiens_hsa050160.61571690
57Systemic lupus erythematosus_Homo sapiens_hsa053220.59687675
58MicroRNAs in cancer_Homo sapiens_hsa052060.58495123
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54764418
60Pentose phosphate pathway_Homo sapiens_hsa000300.54038451
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.53852234
62Hedgehog signaling pathway_Homo sapiens_hsa043400.52246255
63HTLV-I infection_Homo sapiens_hsa051660.51556958
64Arginine and proline metabolism_Homo sapiens_hsa003300.49672406
65Cardiac muscle contraction_Homo sapiens_hsa042600.49624419
66Antigen processing and presentation_Homo sapiens_hsa046120.48095941
67Herpes simplex infection_Homo sapiens_hsa051680.47199515
68Bladder cancer_Homo sapiens_hsa052190.46881307
69Notch signaling pathway_Homo sapiens_hsa043300.46166731
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44357858
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42867102
72Shigellosis_Homo sapiens_hsa051310.42498907
73Regulation of autophagy_Homo sapiens_hsa041400.42171726
74Tight junction_Homo sapiens_hsa045300.40843828
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40596753
76Vitamin digestion and absorption_Homo sapiens_hsa049770.39257559
77N-Glycan biosynthesis_Homo sapiens_hsa005100.35646175
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35139050
79Chronic myeloid leukemia_Homo sapiens_hsa052200.34314139
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32644417
81Insulin signaling pathway_Homo sapiens_hsa049100.32207123
82AMPK signaling pathway_Homo sapiens_hsa041520.31729715
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30429258
84Adherens junction_Homo sapiens_hsa045200.30360440
85Phenylalanine metabolism_Homo sapiens_hsa003600.29265393
86Steroid biosynthesis_Homo sapiens_hsa001000.25730684
87HIF-1 signaling pathway_Homo sapiens_hsa040660.25722171
88Pyruvate metabolism_Homo sapiens_hsa006200.25568784
89Prion diseases_Homo sapiens_hsa050200.25039869
90Vibrio cholerae infection_Homo sapiens_hsa051100.25024093
91Melanoma_Homo sapiens_hsa052180.24918421
92Galactose metabolism_Homo sapiens_hsa000520.24865713
93Colorectal cancer_Homo sapiens_hsa052100.24004353
94Pathways in cancer_Homo sapiens_hsa052000.23036771
95Linoleic acid metabolism_Homo sapiens_hsa005910.22696933
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22385741
97Metabolic pathways_Homo sapiens_hsa011000.22140055
98Wnt signaling pathway_Homo sapiens_hsa043100.21254062
99Melanogenesis_Homo sapiens_hsa049160.19752326
100Vitamin B6 metabolism_Homo sapiens_hsa007500.19680942
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19633337
102Small cell lung cancer_Homo sapiens_hsa052220.19401153
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19327097
104mTOR signaling pathway_Homo sapiens_hsa041500.18867730
105Rap1 signaling pathway_Homo sapiens_hsa040150.18137859
106B cell receptor signaling pathway_Homo sapiens_hsa046620.18073035
107Glucagon signaling pathway_Homo sapiens_hsa049220.17951376
108Lysine degradation_Homo sapiens_hsa003100.17477286
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16367253
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15116728
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14560543
112Parkinsons disease_Homo sapiens_hsa050120.12972128
113Arachidonic acid metabolism_Homo sapiens_hsa005900.12351516
114Apoptosis_Homo sapiens_hsa042100.11694709
115Alcoholism_Homo sapiens_hsa050340.11663171
116Acute myeloid leukemia_Homo sapiens_hsa052210.11021385
117Legionellosis_Homo sapiens_hsa051340.10662434
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07945703
119Tyrosine metabolism_Homo sapiens_hsa003500.07918102
120Prostate cancer_Homo sapiens_hsa052150.07612620
121Fat digestion and absorption_Homo sapiens_hsa049750.06942887
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06821268
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.04435832
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03800159
125Arginine biosynthesis_Homo sapiens_hsa002200.00220029

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