USPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.99039704
2nuclear pore organization (GO:0006999)5.74998911
3centriole replication (GO:0007099)5.43056752
4pore complex assembly (GO:0046931)4.70377063
5mitotic sister chromatid cohesion (GO:0007064)4.57067129
6regulation of helicase activity (GO:0051095)4.31800885
7response to pheromone (GO:0019236)4.20860973
8regulation of centriole replication (GO:0046599)4.15427694
9neural tube formation (GO:0001841)4.12736489
10regulation of mitotic spindle checkpoint (GO:1903504)4.03248219
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.03248219
12protein localization to kinetochore (GO:0034501)4.01296421
13mitotic nuclear envelope disassembly (GO:0007077)3.97097600
14histone mRNA catabolic process (GO:0071044)3.97081198
15mitotic metaphase plate congression (GO:0007080)3.93362624
16DNA replication initiation (GO:0006270)3.89990828
17DNA unwinding involved in DNA replication (GO:0006268)3.87789491
18histone H2A acetylation (GO:0043968)3.81476116
19maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.81201601
20DNA strand elongation involved in DNA replication (GO:0006271)3.79076249
21DNA strand elongation (GO:0022616)3.77945753
22microtubule depolymerization (GO:0007019)3.75783751
23replication fork processing (GO:0031297)3.74303987
24pre-miRNA processing (GO:0031054)3.73646005
25nuclear envelope disassembly (GO:0051081)3.70304803
26membrane disassembly (GO:0030397)3.70304803
27protein localization to chromosome, centromeric region (GO:0071459)3.68412934
28spermatid nucleus differentiation (GO:0007289)3.64819563
29cellular response to interleukin-15 (GO:0071350)3.64311639
30acrosome reaction (GO:0007340)3.64015299
31kinetochore organization (GO:0051383)3.62856773
32rRNA methylation (GO:0031167)3.61624372
33DNA replication-dependent nucleosome organization (GO:0034723)3.60364201
34DNA replication-dependent nucleosome assembly (GO:0006335)3.60364201
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.60284120
36telomere maintenance via semi-conservative replication (GO:0032201)3.56644519
37regulation of histone H3-K9 methylation (GO:0051570)3.55678657
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.54076019
39DNA double-strand break processing (GO:0000729)3.49037051
40centriole assembly (GO:0098534)3.48857591
41peptidyl-lysine trimethylation (GO:0018023)3.48164367
42DNA geometric change (GO:0032392)3.48004701
43telomere maintenance via recombination (GO:0000722)3.47540798
44sister chromatid segregation (GO:0000819)3.47418558
45negative regulation of histone methylation (GO:0031061)3.46913663
46sperm motility (GO:0030317)3.44743197
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44270866
48mismatch repair (GO:0006298)3.43994748
49metaphase plate congression (GO:0051310)3.43230123
50mitotic recombination (GO:0006312)3.42824401
51microtubule polymerization or depolymerization (GO:0031109)3.42727429
52telomere maintenance via telomerase (GO:0007004)3.40220710
53meiotic chromosome segregation (GO:0045132)3.40174210
54DNA duplex unwinding (GO:0032508)3.40174057
55DNA replication-independent nucleosome assembly (GO:0006336)3.39260665
56DNA replication-independent nucleosome organization (GO:0034724)3.39260665
57mitotic sister chromatid segregation (GO:0000070)3.38927781
58DNA replication checkpoint (GO:0000076)3.36041207
59monoubiquitinated protein deubiquitination (GO:0035520)3.34194337
60regulation of telomere maintenance via telomerase (GO:0032210)3.33863636
61histone H3-K4 trimethylation (GO:0080182)3.32978249
62mitotic chromosome condensation (GO:0007076)3.31890175
63intra-S DNA damage checkpoint (GO:0031573)3.29619063
64negative regulation of DNA recombination (GO:0045910)3.29248819
65establishment of protein localization to Golgi (GO:0072600)3.28686084
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.28312484
67chromatin remodeling at centromere (GO:0031055)3.28054844
68kinetochore assembly (GO:0051382)3.26667930
69dosage compensation (GO:0007549)3.23420737
70CENP-A containing nucleosome assembly (GO:0034080)3.23042056
71protein targeting to Golgi (GO:0000042)3.21188643
72translesion synthesis (GO:0019985)3.20380418
73sister chromatid cohesion (GO:0007062)3.18123900
74positive regulation of mitochondrial fission (GO:0090141)3.17585059
75telomere maintenance via telomere lengthening (GO:0010833)3.13740025
76regulation of spindle organization (GO:0090224)3.13246510
77IMP biosynthetic process (GO:0006188)3.12373854
78spindle checkpoint (GO:0031577)3.11888947
79postreplication repair (GO:0006301)3.11786078
80protein K11-linked deubiquitination (GO:0035871)3.11539819
81protein localization to chromosome (GO:0034502)3.10558236
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10030288
83negative regulation of translation, ncRNA-mediated (GO:0040033)3.10030288
84regulation of translation, ncRNA-mediated (GO:0045974)3.10030288
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09229773
86ribosome assembly (GO:0042255)3.08407075
87chromatin assembly or disassembly (GO:0006333)3.03200309
88DNA strand renaturation (GO:0000733)3.02893108
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02872618
90histone mRNA metabolic process (GO:0008334)3.02484000
91histone H3-K9 methylation (GO:0051567)3.02257972
92positive regulation of chromosome segregation (GO:0051984)3.02017926
93regulation of DNA damage checkpoint (GO:2000001)3.01651348
94telomere organization (GO:0032200)3.01099518
95histone exchange (GO:0043486)3.00676416
96regulation of chromosome segregation (GO:0051983)3.00424016
97nucleobase biosynthetic process (GO:0046112)3.00379044
98spindle assembly checkpoint (GO:0071173)3.00186768
99telomere maintenance (GO:0000723)2.99826105
100response to interleukin-15 (GO:0070672)2.99692744
101negative regulation of chromosome segregation (GO:0051985)2.98534720
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98279739
103negative regulation of sister chromatid segregation (GO:0033046)2.98279739
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.98279739
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98279739
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96565106
107somatic hypermutation of immunoglobulin genes (GO:0016446)2.96565106
108double-strand break repair via homologous recombination (GO:0000724)2.95936491
109DNA-dependent DNA replication (GO:0006261)2.93304319
110mRNA transport (GO:0051028)2.93076699
111recombinational repair (GO:0000725)2.92589827
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92334345
113microtubule nucleation (GO:0007020)2.92007233
114reciprocal meiotic recombination (GO:0007131)2.91133177
115reciprocal DNA recombination (GO:0035825)2.91133177
116establishment of chromosome localization (GO:0051303)2.91132641
117mitotic spindle assembly checkpoint (GO:0007094)2.91095548
118mitotic spindle checkpoint (GO:0071174)2.90035629
119ATP-dependent chromatin remodeling (GO:0043044)2.89897274
120DNA conformation change (GO:0071103)2.89617586
121histone H2A monoubiquitination (GO:0035518)2.88618198
122ribosome biogenesis (GO:0042254)2.88260936
123retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87768055
124regulation of mitotic sister chromatid separation (GO:0010965)2.87592272
125regulation of mitotic sister chromatid segregation (GO:0033047)2.87592272
126regulation of sister chromatid segregation (GO:0033045)2.87592272
127attachment of spindle microtubules to kinetochore (GO:0008608)2.87479218
128mRNA export from nucleus (GO:0006406)2.87368069
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86282689
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85809555
131chromosome segregation (GO:0007059)2.85486100
132positive regulation of developmental pigmentation (GO:0048087)2.84247768
133protein prenylation (GO:0018342)2.76979553
134prenylation (GO:0097354)2.76979553
135rRNA modification (GO:0000154)2.75019380
136histone H3-K9 modification (GO:0061647)2.73909602
137mitotic G2 DNA damage checkpoint (GO:0007095)2.70922571
138positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.65216256
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.65216256
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.65216256
141regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.61851804
142positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.61388615
143phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.61098640
144regulation of DNA endoreduplication (GO:0032875)2.59748015
145microtubule anchoring (GO:0034453)2.59600404
146regulation of centrosome duplication (GO:0010824)2.59581020
147synapsis (GO:0007129)2.58895645
148mitotic G2/M transition checkpoint (GO:0044818)2.58593548
149activated T cell proliferation (GO:0050798)2.56309112
150regulation of telomere maintenance (GO:0032204)2.50899742
151cellular response to ethanol (GO:0071361)2.50789067
152somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50748885
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50748885
154isotype switching (GO:0045190)2.50748885
155RNA destabilization (GO:0050779)2.49554077
156lymphoid progenitor cell differentiation (GO:0002320)2.48908223
157negative regulation of inclusion body assembly (GO:0090084)2.48425706
158somite development (GO:0061053)2.48085355
159regulation of DNA recombination (GO:0000018)2.47488359
160olfactory bulb development (GO:0021772)2.46426870
161regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.45493234
162spermatid development (GO:0007286)2.44813971
163regulation of meiosis I (GO:0060631)2.44611515
164pyrimidine dimer repair (GO:0006290)2.43856983
165regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.43339235
166DNA packaging (GO:0006323)2.42880084
167protein K48-linked deubiquitination (GO:0071108)2.41027970
168seminiferous tubule development (GO:0072520)2.40956456
169resolution of meiotic recombination intermediates (GO:0000712)2.40801221
170response to X-ray (GO:0010165)2.39780492
171mitochondrial fission (GO:0000266)2.38796411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.76141037
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.26033150
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21959098
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.19050147
5POU3F2_20337985_ChIP-ChIP_501MEL_Human3.08593422
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.05167036
7ZNF274_21170338_ChIP-Seq_K562_Hela2.83662793
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81023923
9VDR_22108803_ChIP-Seq_LS180_Human2.67103740
10IGF1R_20145208_ChIP-Seq_DFB_Human2.64557723
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57819017
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57598700
13TAF15_26573619_Chip-Seq_HEK293_Human2.56339259
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52415394
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47290812
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43613059
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.40533140
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.39585690
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.35391558
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34826473
21FUS_26573619_Chip-Seq_HEK293_Human2.30641297
22YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29078164
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.27081223
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.24387926
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.24375838
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14305797
27* E2F1_21310950_ChIP-Seq_MCF-7_Human2.12577320
28* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07509014
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05423219
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05331079
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05067481
32E2F7_22180533_ChIP-Seq_HELA_Human10.3125947
33* VDR_23849224_ChIP-Seq_CD4+_Human1.99847660
34EWS_26573619_Chip-Seq_HEK293_Human1.99118603
35* MYC_22102868_ChIP-Seq_BL_Human1.97605343
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96212020
37CIITA_25753668_ChIP-Seq_RAJI_Human1.95901007
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93646736
39FOXP3_21729870_ChIP-Seq_TREG_Human1.91865164
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91176965
41* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90755203
42* ETS1_20019798_ChIP-Seq_JURKAT_Human1.88724195
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87536025
44* XRN2_22483619_ChIP-Seq_HELA_Human1.87211699
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87170325
46AR_21909140_ChIP-Seq_LNCAP_Human1.86963123
47ER_23166858_ChIP-Seq_MCF-7_Human1.83639840
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82147955
49* P300_19829295_ChIP-Seq_ESCs_Human1.81475572
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.78690614
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75577033
52* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75419868
53* GABP_17652178_ChIP-ChIP_JURKAT_Human1.72338242
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71482774
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71211496
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70478349
57CBP_20019798_ChIP-Seq_JUKART_Human1.70478349
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70347357
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70050624
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69410710
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68463420
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68176934
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64526855
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64128288
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59456387
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58238130
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57501830
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55390635
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54085214
70ELK1_19687146_ChIP-ChIP_HELA_Human1.53933978
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51805350
72GBX2_23144817_ChIP-Seq_PC3_Human1.50697129
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49661089
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48165482
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47272870
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45579386
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45579386
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45131870
79* GABP_19822575_ChIP-Seq_HepG2_Human1.44989795
80KDM5A_27292631_Chip-Seq_BREAST_Human1.44542848
81STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44016187
82* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42776050
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42737989
84* TTF2_22483619_ChIP-Seq_HELA_Human1.42125261
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40098846
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.40017747
87* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39429272
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39084768
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.36623142
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35733609
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32580559
92IRF1_19129219_ChIP-ChIP_H3396_Human1.32466891
93* DCP1A_22483619_ChIP-Seq_HELA_Human1.30104946
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28571099
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27339052
96* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26148739
97* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25114967
98* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23748606
99SMAD4_21799915_ChIP-Seq_A2780_Human1.23066303
100* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22206104
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21869414
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.21466840
103* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21217543
104GATA3_26560356_Chip-Seq_TH2_Human1.20670206
105* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20654218
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18556882
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18357561
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18264879
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18072258
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17570212
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16333591
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16202272
113STAT3_23295773_ChIP-Seq_U87_Human1.15462238
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15266309
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14514567
116RUNX_20019798_ChIP-Seq_JUKART_Human1.14474567
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13135000
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12036729
119* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11774474
120AR_25329375_ChIP-Seq_VCAP_Human1.11659670
121SOX2_19829295_ChIP-Seq_ESCs_Human1.10318023
122NANOG_19829295_ChIP-Seq_ESCs_Human1.10318023
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09731640
124SALL4_22934838_ChIP-ChIP_CD34+_Human1.09531441
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09035385
126GATA3_27048872_Chip-Seq_THYMUS_Human1.09016150
127* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07349140
128TCF4_23295773_ChIP-Seq_U87_Human1.07180360
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06867857
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06374889
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.05986844
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05720386
133* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05019514
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.04985281
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04916337
136RUNX2_22187159_ChIP-Seq_PCA_Human1.04610920
137VDR_24787735_ChIP-Seq_THP-1_Human1.04049942
138SMAD_19615063_ChIP-ChIP_OVARY_Human1.03979580
139P300_18555785_Chip-Seq_ESCs_Mouse1.03203939
140IRF8_21731497_ChIP-ChIP_J774_Mouse1.02983977
141TCF4_22108803_ChIP-Seq_LS180_Human1.02618753
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02551346
143E2F1_18555785_Chip-Seq_ESCs_Mouse1.02283148
144P53_22387025_ChIP-Seq_ESCs_Mouse1.02132804
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02088859
146* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01990432
147NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01524272
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01361887
149* NANOG_21062744_ChIP-ChIP_HESCs_Human1.00967957
150GATA3_26560356_Chip-Seq_TH1_Human1.00360922
151* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98568710
152TFEB_21752829_ChIP-Seq_HELA_Human0.97958398
153HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96985441
154* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96787705
155POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94059717
156* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93820050
157YY1_21170310_ChIP-Seq_MESCs_Mouse0.93789933
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92845993
159NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91870312
160ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90400662
161TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90142487
162* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90095833
163POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89757926
164* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89597837
165NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88785447
166SRF_21415370_ChIP-Seq_HL-1_Mouse0.87172984
167KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85948693
168MYB_26560356_Chip-Seq_TH2_Human0.81293358
169DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80564923
170SOX2_16153702_ChIP-ChIP_HESCs_Human0.79064660
171KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78855862
172KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78855862
173KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78855862
174MYC_18940864_ChIP-ChIP_HL60_Human0.78794101
175MYB_26560356_Chip-Seq_TH1_Human0.78616034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.77278783
2MP0008057_abnormal_DNA_replication4.40732127
3MP0003111_abnormal_nucleus_morphology4.15238308
4MP0003693_abnormal_embryo_hatching3.96483337
5MP0003077_abnormal_cell_cycle3.54215583
6MP0008058_abnormal_DNA_repair3.51378732
7MP0004957_abnormal_blastocyst_morpholog3.37103192
8MP0008007_abnormal_cellular_replicative2.85231667
9MP0008877_abnormal_DNA_methylation2.51924756
10MP0005410_abnormal_fertilization2.43626343
11MP0003221_abnormal_cardiomyocyte_apopto2.38776658
12MP0002653_abnormal_ependyma_morphology2.18534906
13MP0003787_abnormal_imprinting2.17964869
14MP0001835_abnormal_antigen_presentation2.14641149
15MP0003121_genomic_imprinting2.14123228
16MP0000350_abnormal_cell_proliferation2.12411115
17MP0002396_abnormal_hematopoietic_system2.12357617
18MP0003724_increased_susceptibility_to2.02208402
19MP0001730_embryonic_growth_arrest1.98836921
20MP0005367_renal/urinary_system_phenotyp1.96232618
21MP0000516_abnormal_urinary_system1.96232618
22MP0003890_abnormal_embryonic-extraembry1.95641861
23MP0008932_abnormal_embryonic_tissue1.90880699
24MP0003123_paternal_imprinting1.85579377
25MP0010307_abnormal_tumor_latency1.80658560
26MP0004808_abnormal_hematopoietic_stem1.79529345
27MP0001672_abnormal_embryogenesis/_devel1.73131495
28MP0005380_embryogenesis_phenotype1.73131495
29MP0000465_gastrointestinal_hemorrhage1.69876658
30MP0000569_abnormal_digit_pigmentation1.69532923
31MP0002085_abnormal_embryonic_tissue1.67620318
32MP0001697_abnormal_embryo_size1.63725561
33MP0002084_abnormal_developmental_patter1.62631891
34MP0003763_abnormal_thymus_physiology1.61138564
35MP0004197_abnormal_fetal_growth/weight/1.59508790
36MP0003984_embryonic_growth_retardation1.57658161
37MP0003786_premature_aging1.57009733
38MP0002088_abnormal_embryonic_growth/wei1.55125546
39MP0006292_abnormal_olfactory_placode1.50704531
40MP0000703_abnormal_thymus_morphology1.49909332
41MP0005076_abnormal_cell_differentiation1.49236886
42MP0009697_abnormal_copulation1.47490480
43MP0005253_abnormal_eye_physiology1.45156463
44MP0001986_abnormal_taste_sensitivity1.43359183
45MP0005310_abnormal_salivary_gland1.39182283
46MP0002210_abnormal_sex_determination1.38616753
47MP0002086_abnormal_extraembryonic_tissu1.38538250
48MP0003880_abnormal_central_pattern1.38005628
49MP0002080_prenatal_lethality1.36678172
50MP0009764_decreased_sensitivity_to1.35786767
51MP0005084_abnormal_gallbladder_morpholo1.34910372
52MP0000490_abnormal_crypts_of1.34383791
53MP0010352_gastrointestinal_tract_polyps1.33774698
54MP0002009_preneoplasia1.28527068
55MP0000313_abnormal_cell_death1.27578709
56MP0003315_abnormal_perineum_morphology1.24354925
57MP0002723_abnormal_immune_serum1.22307294
58MP0005248_abnormal_Harderian_gland1.22121547
59MP0000015_abnormal_ear_pigmentation1.20482660
60MP0002452_abnormal_antigen_presenting1.20252935
61MP0008995_early_reproductive_senescence1.19911866
62MP0000372_irregular_coat_pigmentation1.18559844
63MP0005000_abnormal_immune_tolerance1.17901442
64MP0001929_abnormal_gametogenesis1.17648987
65MP0002398_abnormal_bone_marrow1.16724006
66MP0003136_yellow_coat_color1.16131023
67MP0003656_abnormal_erythrocyte_physiolo1.15946718
68MP0002019_abnormal_tumor_incidence1.14351780
69MP0001145_abnormal_male_reproductive1.13415861
70MP0000566_synostosis1.11043056
71MP0002420_abnormal_adaptive_immunity1.09382625
72MP0000383_abnormal_hair_follicle1.09374505
73MP0003646_muscle_fatigue1.08855412
74MP0001819_abnormal_immune_cell1.07395705
75MP0010678_abnormal_skin_adnexa1.04345550
76MP0004133_heterotaxia1.04140630
77MP0002102_abnormal_ear_morphology1.03388193
78MP0001293_anophthalmia1.03205846
79MP0004484_altered_response_of1.03104439
80MP0002938_white_spotting1.02235209
81MP0002095_abnormal_skin_pigmentation1.02058695
82MP0003119_abnormal_digestive_system1.00659384
83MP0000653_abnormal_sex_gland0.99061438
84MP0009703_decreased_birth_body0.98564661
85MP0002722_abnormal_immune_system0.98517206
86MP0003937_abnormal_limbs/digits/tail_de0.97663579
87MP0000537_abnormal_urethra_morphology0.96787542
88MP0000427_abnormal_hair_cycle0.96488072
89MP0002751_abnormal_autonomic_nervous0.96314033
90MP0001324_abnormal_eye_pigmentation0.95909577
91MP0005670_abnormal_white_adipose0.94494454
92MP0001119_abnormal_female_reproductive0.94245359
93MP0009672_abnormal_birth_weight0.93932506
94MP0009785_altered_susceptibility_to0.92333448
95MP0004381_abnormal_hair_follicle0.92126789
96MP0002132_abnormal_respiratory_system0.91960954
97MP0001286_abnormal_eye_development0.91919869
98MP0005174_abnormal_tail_pigmentation0.91862776
99MP0003567_abnormal_fetal_cardiomyocyte0.90893829
100MP0000689_abnormal_spleen_morphology0.90372227
101MP0009765_abnormal_xenobiotic_induced0.89634590
102MP0005377_hearing/vestibular/ear_phenot0.89535745
103MP0003878_abnormal_ear_physiology0.89535745
104MP0010030_abnormal_orbit_morphology0.89041395
105MP0002928_abnormal_bile_duct0.88600393
106MP0002075_abnormal_coat/hair_pigmentati0.88286843
107MP0004264_abnormal_extraembryonic_tissu0.86215131
108MP0005395_other_phenotype0.86078941
109MP0003941_abnormal_skin_development0.85372758
110MP0008789_abnormal_olfactory_epithelium0.84361872
111MP0001915_intracranial_hemorrhage0.84113077
112MP0003861_abnormal_nervous_system0.83980378
113MP0001486_abnormal_startle_reflex0.83155592
114MP0005391_vision/eye_phenotype0.82801036
115MP0002160_abnormal_reproductive_system0.82428651
116MP0000428_abnormal_craniofacial_morphol0.82405276
117MP0003698_abnormal_male_reproductive0.81725208
118MP0009333_abnormal_splenocyte_physiolog0.81247240
119MP0000778_abnormal_nervous_system0.79707087
120MP0002419_abnormal_innate_immunity0.79627587
121MP0003943_abnormal_hepatobiliary_system0.78457244
122MP0001529_abnormal_vocalization0.77709919
123MP0003115_abnormal_respiratory_system0.77318109
124MP0002282_abnormal_trachea_morphology0.75710030
125MP0002429_abnormal_blood_cell0.75284303
126MP0000371_diluted_coat_color0.74571787
127MP0003935_abnormal_craniofacial_develop0.72979118
128MP0000716_abnormal_immune_system0.72243795
129MP0001800_abnormal_humoral_immune0.71070739
130MP0006072_abnormal_retinal_apoptosis0.70514643
131MP0001853_heart_inflammation0.70425288
132MP0004742_abnormal_vestibular_system0.70330565
133MP0001188_hyperpigmentation0.70263252
134MP0000432_abnormal_head_morphology0.69751720
135MP0002148_abnormal_hypersensitivity_rea0.69015878
136MP0003718_maternal_effect0.68889305
137MP0001186_pigmentation_phenotype0.68198952
138MP0002277_abnormal_respiratory_mucosa0.68051340
139MP0005075_abnormal_melanosome_morpholog0.68040490
140MP0001545_abnormal_hematopoietic_system0.67800968
141MP0005397_hematopoietic_system_phenotyp0.67800968
142MP0002166_altered_tumor_susceptibility0.67614792
143MP0005671_abnormal_response_to0.67599491
144MP0002006_tumorigenesis0.67083512
145MP0004215_abnormal_myocardial_fiber0.66449478
146MP0002735_abnormal_chemical_nociception0.66141301
147MP0005025_abnormal_response_to0.65972701

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.89204812
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.59804206
3Chromsome breakage (HP:0040012)4.48411686
4Tubulointerstitial nephritis (HP:0001970)4.00209118
5Chronic hepatic failure (HP:0100626)3.93762659
6Abnormality of the fingertips (HP:0001211)3.41578311
7Medulloblastoma (HP:0002885)3.40890216
8Birth length less than 3rd percentile (HP:0003561)3.38619738
9Abnormality of chromosome stability (HP:0003220)3.26773807
10Ependymoma (HP:0002888)3.16310602
11Abnormality of the ileum (HP:0001549)3.08919241
12Ectopic kidney (HP:0000086)2.96874331
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.94230929
14Neoplasm of the oral cavity (HP:0100649)2.89697664
15Meckel diverticulum (HP:0002245)2.86607665
16Selective tooth agenesis (HP:0001592)2.83230722
17Patellar aplasia (HP:0006443)2.74904327
18Abnormality of the labia minora (HP:0012880)2.74047309
19Abnormality of the preputium (HP:0100587)2.69838242
20Impulsivity (HP:0100710)2.69786494
21Aplasia/Hypoplasia of the tibia (HP:0005772)2.69078268
22Abnormal number of incisors (HP:0011064)2.67902370
23Short tibia (HP:0005736)2.65707501
24Abnormal hair whorl (HP:0010721)2.64386669
25Amaurosis fugax (HP:0100576)2.60714666
26Supernumerary spleens (HP:0009799)2.59378374
27Prominent nose (HP:0000448)2.57762844
28Glioma (HP:0009733)2.56312325
29Intestinal atresia (HP:0011100)2.54416351
30Myelodysplasia (HP:0002863)2.49390854
31Long eyelashes (HP:0000527)2.48752906
32Increased nuchal translucency (HP:0010880)2.48392329
33Aplasia/Hypoplasia of the patella (HP:0006498)2.48165343
3411 pairs of ribs (HP:0000878)2.46346048
35Astrocytoma (HP:0009592)2.45516950
36Abnormality of the astrocytes (HP:0100707)2.45516950
37Abnormality of the carotid arteries (HP:0005344)2.40971411
38Sloping forehead (HP:0000340)2.39492205
39Nephroblastoma (Wilms tumor) (HP:0002667)2.38661590
40Papillary thyroid carcinoma (HP:0002895)2.36206794
41Abnormality of lateral ventricle (HP:0030047)2.35345445
42Colon cancer (HP:0003003)2.33609477
43Small intestinal stenosis (HP:0012848)2.31319086
44Duodenal stenosis (HP:0100867)2.31319086
45Bone marrow hypocellularity (HP:0005528)2.30635343
46Stomatitis (HP:0010280)2.30463465
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29647498
48Short 4th metacarpal (HP:0010044)2.29647498
49Optic nerve coloboma (HP:0000588)2.29585059
50High anterior hairline (HP:0009890)2.29476504
51Broad alveolar ridges (HP:0000187)2.28379660
52Neoplasm of the pancreas (HP:0002894)2.25788741
53Albinism (HP:0001022)2.24947521
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.24935085
55Pancreatic cysts (HP:0001737)2.22502796
56T lymphocytopenia (HP:0005403)2.21655037
57Embryonal renal neoplasm (HP:0011794)2.20298855
58Absent speech (HP:0001344)2.17820096
59Lip pit (HP:0100267)2.13754554
60Deep philtrum (HP:0002002)2.13641919
61Proximal placement of thumb (HP:0009623)2.13423129
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12077600
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.12077600
64Tented upper lip vermilion (HP:0010804)2.11715014
65Facial hemangioma (HP:0000329)2.08691900
66Thyroid carcinoma (HP:0002890)2.07889276
67Recurrent cutaneous fungal infections (HP:0011370)2.05880173
68Chronic mucocutaneous candidiasis (HP:0002728)2.05880173
69Bony spicule pigmentary retinopathy (HP:0007737)2.05042684
70Capillary hemangiomas (HP:0005306)2.04766817
71Dyschromatopsia (HP:0007641)2.03490592
72Abnormality of the duodenum (HP:0002246)2.02810916
73Deviation of the thumb (HP:0009603)2.01388512
74Clitoromegaly (HP:0000057)2.01089204
75Tubulointerstitial abnormality (HP:0001969)2.00814841
76Neoplasm of the tracheobronchial system (HP:0100552)2.00634220
77Oligodactyly (hands) (HP:0001180)1.99945640
78Basal cell carcinoma (HP:0002671)1.99772261
79Premature graying of hair (HP:0002216)1.98669593
80Abnormality of T cell number (HP:0011839)1.98202028
81Degeneration of anterior horn cells (HP:0002398)1.97829189
82Abnormality of the anterior horn cell (HP:0006802)1.97829189
83Acute myeloid leukemia (HP:0004808)1.97508722
84Stomach cancer (HP:0012126)1.97060400
85Cafe-au-lait spot (HP:0000957)1.95939771
86Abnormality of B cell number (HP:0010975)1.95936552
87B lymphocytopenia (HP:0010976)1.95936552
88Clubbing of toes (HP:0100760)1.94837267
89Progressive cerebellar ataxia (HP:0002073)1.94102787
90Renal cortical cysts (HP:0000803)1.93976083
91Rhabdomyosarcoma (HP:0002859)1.93550607
92Cellular immunodeficiency (HP:0005374)1.91321580
93Panhypogammaglobulinemia (HP:0003139)1.91163187
94Cone-rod dystrophy (HP:0000548)1.90893128
95Agnosia (HP:0010524)1.90740762
96Abnormality of the renal cortex (HP:0011035)1.89609619
97Urethral obstruction (HP:0000796)1.89008986
98Abnormality of the intervertebral disk (HP:0005108)1.87776684
99Cupped ear (HP:0000378)1.87611148
100Short thumb (HP:0009778)1.87403950
101Hematochezia (HP:0002573)1.87396592
102Abnormality of DNA repair (HP:0003254)1.86515290
103Neoplasm of striated muscle (HP:0009728)1.85635038
104Curly hair (HP:0002212)1.85565104
105Severe combined immunodeficiency (HP:0004430)1.85202144
106Pancreatic fibrosis (HP:0100732)1.84579280
107Pendular nystagmus (HP:0012043)1.84103774
108Lymphoma (HP:0002665)1.83581850
109Duplicated collecting system (HP:0000081)1.81928122
110Heterotopia (HP:0002282)1.81227310
111Biliary tract neoplasm (HP:0100574)1.80556123
112Abnormal lung lobation (HP:0002101)1.80139453
113Dyskinesia (HP:0100660)1.79321934
114Broad palm (HP:0001169)1.79270187
115Absent radius (HP:0003974)1.78846851
116Acute lymphatic leukemia (HP:0006721)1.77362052
117Tracheoesophageal fistula (HP:0002575)1.77282682
118Abnormality of the renal collecting system (HP:0004742)1.76156891
119Neoplasm of the adrenal cortex (HP:0100641)1.76112626
120Alveolar cell carcinoma (HP:0006519)1.76011668
121Supernumerary ribs (HP:0005815)1.75970732
122Retrobulbar optic neuritis (HP:0100654)1.75708750
123Optic neuritis (HP:0100653)1.75708750
124Abnormality of eosinophils (HP:0001879)1.75111685
125Progressive inability to walk (HP:0002505)1.73536707
126Supernumerary bones of the axial skeleton (HP:0009144)1.73090843
127Attenuation of retinal blood vessels (HP:0007843)1.73087907
128Abnormality of chromosome segregation (HP:0002916)1.72982950
129Abnormality of the renal medulla (HP:0100957)1.72343459
130Cutis marmorata (HP:0000965)1.70853681
131Abnormality of T cells (HP:0002843)1.70179792
132Methylmalonic acidemia (HP:0002912)1.69878174
133Leukocytosis (HP:0001974)1.68244294
134Breast hypoplasia (HP:0003187)1.67010832
135Hypoplasia of the thymus (HP:0000778)1.66860624
136Nephronophthisis (HP:0000090)1.66829087
137Abnormality of midbrain morphology (HP:0002418)1.66810436
138Molar tooth sign on MRI (HP:0002419)1.66810436
139Thyroiditis (HP:0100646)1.66708347
140Oligodactyly (HP:0012165)1.66261360
141Genetic anticipation (HP:0003743)1.65991329
142Gastrointestinal atresia (HP:0002589)1.65371639
143Increased number of teeth (HP:0011069)1.65138236
144Absent forearm bone (HP:0003953)1.65048234
145Aplasia involving forearm bones (HP:0009822)1.65048234
146Truncal obesity (HP:0001956)1.63879571
147Chronic diarrhea (HP:0002028)1.63437587
148Hypochromic microcytic anemia (HP:0004840)1.63294883
149Combined immunodeficiency (HP:0005387)1.63141132
150Fibular hypoplasia (HP:0003038)1.62397907
151Malignant gastrointestinal tract tumors (HP:0006749)1.61516829
152Gastrointestinal carcinoma (HP:0002672)1.61516829
153Pancreatic islet-cell hyperplasia (HP:0004510)1.60645172
154Abnormality of the prostate (HP:0008775)1.59962290
155Hypoplastic labia majora (HP:0000059)1.58465262
156Severe visual impairment (HP:0001141)1.58168037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.54121013
2CDK123.58638250
3SRPK13.46224975
4CDC73.45979239
5WNK33.33997668
6INSRR3.15697566
7WEE12.90717249
8NEK22.85923944
9FRK2.64446697
10MKNK22.37855062
11TSSK62.37437418
12BRSK22.32825091
13BRD42.26628987
14BUB12.25570055
15TTK2.19423936
16TRIM282.18451445
17ATR2.13916908
18PNCK2.10341005
19CHEK21.96731446
20PLK31.88131544
21ZAK1.86725719
22MKNK11.83260182
23PLK11.78431086
24CDK71.76859686
25TXK1.76377787
26PLK21.73214302
27ACVR1B1.70996952
28LATS11.66610042
29VRK11.60959351
30TAOK31.58281972
31CHEK11.51330075
32MAP3K141.50687653
33CDK41.40440031
34AURKB1.36939210
35YES11.36926125
36CDK81.34792382
37EIF2AK11.33698214
38TGFBR11.31028429
39BRSK11.30734449
40ATM1.29054109
41NEK11.28030178
42MAP4K21.26041086
43BCR1.25968317
44STK31.25394599
45IKBKE1.24381753
46IRAK11.22454875
47TLK11.22425914
48CDK91.21220492
49STK41.11565966
50EPHA31.10051768
51EPHA21.09255572
52PLK41.09105869
53MAPK131.08098727
54MST41.07673788
55PIM11.02777326
56CDK21.02320392
57MAP4K10.96680009
58IKBKB0.95538997
59CLK10.94939226
60IRAK20.94845796
61MELK0.94652865
62RPS6KB20.92323568
63MAP3K40.91185709
64CDK10.90328813
65BMPR20.88422456
66NUAK10.85200119
67DYRK30.82561796
68CDK190.81518480
69EIF2AK20.80923757
70STK100.80827310
71MTOR0.80454414
72JAK30.78491869
73SGK20.77180398
74TNIK0.77034792
75CSF1R0.76818250
76ALK0.76195083
77CSNK1D0.75579024
78STK38L0.74197433
79PIK3CG0.73299043
80FES0.71475106
81NLK0.69555026
82BMPR1B0.69049516
83EIF2AK30.68702538
84OXSR10.66771476
85CDK30.66648809
86LYN0.65743263
87DYRK1A0.65601815
88NEK60.64613503
89RPS6KA40.62969859
90CDK60.61627582
91JAK10.60721411
92DYRK1B0.60193621
93MARK30.59473198
94CCNB10.59266183
95CHUK0.58262277
96MAP3K80.58019925
97MAPK140.56724511
98ERBB30.56491063
99CAMK1D0.55640197
100PRKDC0.55479362
101AURKA0.55253742
102MAP2K70.54173202
103STK160.54105952
104EEF2K0.53857698
105MAPK150.53658798
106CSNK2A20.53557185
107RPS6KB10.53242134
108GSK3B0.52677155
109FLT30.52436992
110CSNK1A1L0.51261538
111PIK3CA0.51104236
112LCK0.50467064
113EPHA40.50013172
114SYK0.49628765
115CSNK1G20.49095533
116TEC0.48300945
117PINK10.45963164
118STK390.45750983
119SIK30.45533645
120JAK20.45114990
121MAP3K100.44733083
122PBK0.44422117
123CSK0.44183860
124FGFR10.43877100
125SIK20.43681999
126IRAK40.43670688
127KIT0.43297004
128BTK0.42323202
129DYRK20.42214455
130ERBB20.42111175
131TAOK20.41838546
132KSR20.41379086
133CSNK1E0.39546906
134MAPK100.39194430
135CSNK1G30.38178116
136PAK40.37651122
137LATS20.37396627
138AKT10.37236292
139MAPK10.36382382
140TYK20.36378889
141KSR10.36211633
142ITK0.36150876
143BLK0.35550374
144EGFR0.34542963
145RPS6KA50.33945404
146CSNK1G10.33631647
147FGR0.32220395
148AKT30.31785748
149TNK20.31200159
150CSNK2A10.30982336
151SCYL20.30713797
152CAMK40.30559936
153PRPF4B0.29477613

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.39015769
2DNA replication_Homo sapiens_hsa030304.13204636
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79669593
4RNA transport_Homo sapiens_hsa030133.22707996
5Spliceosome_Homo sapiens_hsa030403.13239513
6Cell cycle_Homo sapiens_hsa041102.92381409
7Fanconi anemia pathway_Homo sapiens_hsa034602.75964528
8Homologous recombination_Homo sapiens_hsa034402.74331770
9RNA polymerase_Homo sapiens_hsa030202.66472153
10Non-homologous end-joining_Homo sapiens_hsa034502.59577949
11Base excision repair_Homo sapiens_hsa034102.56776805
12Nucleotide excision repair_Homo sapiens_hsa034202.49760862
13mRNA surveillance pathway_Homo sapiens_hsa030152.49637891
14Protein export_Homo sapiens_hsa030602.47696824
15Asthma_Homo sapiens_hsa053102.45268953
16One carbon pool by folate_Homo sapiens_hsa006702.29592162
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29344208
18RNA degradation_Homo sapiens_hsa030182.25565039
19Basal transcription factors_Homo sapiens_hsa030222.14661613
20Pyrimidine metabolism_Homo sapiens_hsa002401.89437463
21p53 signaling pathway_Homo sapiens_hsa041151.69136757
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55106455
23Systemic lupus erythematosus_Homo sapiens_hsa053221.55025077
24Primary immunodeficiency_Homo sapiens_hsa053401.48301592
25Leishmaniasis_Homo sapiens_hsa051401.47811389
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45842159
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37711883
28Herpes simplex infection_Homo sapiens_hsa051681.31387969
29Viral carcinogenesis_Homo sapiens_hsa052031.25876334
30Epstein-Barr virus infection_Homo sapiens_hsa051691.22697712
31MicroRNAs in cancer_Homo sapiens_hsa052061.17842656
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14097694
33Toxoplasmosis_Homo sapiens_hsa051451.13401032
34Regulation of autophagy_Homo sapiens_hsa041401.13027049
35Propanoate metabolism_Homo sapiens_hsa006401.12971170
36Notch signaling pathway_Homo sapiens_hsa043301.12186296
37Antigen processing and presentation_Homo sapiens_hsa046121.11925196
38Purine metabolism_Homo sapiens_hsa002301.08499529
39HTLV-I infection_Homo sapiens_hsa051661.05496451
40Steroid biosynthesis_Homo sapiens_hsa001001.02803993
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01681353
42Basal cell carcinoma_Homo sapiens_hsa052171.00198057
43Colorectal cancer_Homo sapiens_hsa052100.97570790
44Lysine degradation_Homo sapiens_hsa003100.95968474
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95500671
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95022723
47Measles_Homo sapiens_hsa051620.94054453
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.93916581
49Proteasome_Homo sapiens_hsa030500.93906987
50Osteoclast differentiation_Homo sapiens_hsa043800.91764168
51Staphylococcus aureus infection_Homo sapiens_hsa051500.91110831
52Tuberculosis_Homo sapiens_hsa051520.88791593
53Olfactory transduction_Homo sapiens_hsa047400.83802365
54Oocyte meiosis_Homo sapiens_hsa041140.83441328
55Alcoholism_Homo sapiens_hsa050340.82705909
56Ribosome_Homo sapiens_hsa030100.79447710
57Small cell lung cancer_Homo sapiens_hsa052220.76943825
58mTOR signaling pathway_Homo sapiens_hsa041500.76533216
59Chronic myeloid leukemia_Homo sapiens_hsa052200.69634804
60Butanoate metabolism_Homo sapiens_hsa006500.69106184
61T cell receptor signaling pathway_Homo sapiens_hsa046600.68866381
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.68805905
63FoxO signaling pathway_Homo sapiens_hsa040680.68712297
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68162999
65Rheumatoid arthritis_Homo sapiens_hsa053230.66373585
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.65476004
67Selenocompound metabolism_Homo sapiens_hsa004500.65462738
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64969507
69Dorso-ventral axis formation_Homo sapiens_hsa043200.63736300
70Influenza A_Homo sapiens_hsa051640.62097306
71African trypanosomiasis_Homo sapiens_hsa051430.61991406
72Hippo signaling pathway_Homo sapiens_hsa043900.61143217
73Hepatitis B_Homo sapiens_hsa051610.60763849
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60314787
75Nicotine addiction_Homo sapiens_hsa050330.59862617
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59324689
77Taste transduction_Homo sapiens_hsa047420.58852330
78TGF-beta signaling pathway_Homo sapiens_hsa043500.57816648
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55675723
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.54575360
81Chemokine signaling pathway_Homo sapiens_hsa040620.54239955
82Thyroid cancer_Homo sapiens_hsa052160.54085829
83Prostate cancer_Homo sapiens_hsa052150.53685468
84Inositol phosphate metabolism_Homo sapiens_hsa005620.53321563
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52549425
86Wnt signaling pathway_Homo sapiens_hsa043100.51520817
87Hematopoietic cell lineage_Homo sapiens_hsa046400.50718784
88Pathways in cancer_Homo sapiens_hsa052000.50514060
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50481984
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50307406
91Acute myeloid leukemia_Homo sapiens_hsa052210.49133672
92Endometrial cancer_Homo sapiens_hsa052130.48811079
93Legionellosis_Homo sapiens_hsa051340.48405281
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48290695
95Non-small cell lung cancer_Homo sapiens_hsa052230.48072346
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47732804
97Hedgehog signaling pathway_Homo sapiens_hsa043400.46461432
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45401917
99TNF signaling pathway_Homo sapiens_hsa046680.44092192
100Pancreatic cancer_Homo sapiens_hsa052120.43936968
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41796848
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40998392
103Adherens junction_Homo sapiens_hsa045200.40740491
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40061214
105Choline metabolism in cancer_Homo sapiens_hsa052310.39990742
106Apoptosis_Homo sapiens_hsa042100.38971109
107Circadian rhythm_Homo sapiens_hsa047100.38591269
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.37859027
109Phototransduction_Homo sapiens_hsa047440.37728929
110Type I diabetes mellitus_Homo sapiens_hsa049400.36871749
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34931971
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32813618
113Graft-versus-host disease_Homo sapiens_hsa053320.32206535
114Long-term depression_Homo sapiens_hsa047300.32108393
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32070914
116Allograft rejection_Homo sapiens_hsa053300.31816261
117Viral myocarditis_Homo sapiens_hsa054160.31691461
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31418669
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31334031
120Renin secretion_Homo sapiens_hsa049240.31195284
121Pentose phosphate pathway_Homo sapiens_hsa000300.31134262
122Prolactin signaling pathway_Homo sapiens_hsa049170.30021217
123Melanoma_Homo sapiens_hsa052180.28589535
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.28575090
125Estrogen signaling pathway_Homo sapiens_hsa049150.28382678
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28228117
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27633112
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27091395
129HIF-1 signaling pathway_Homo sapiens_hsa040660.26294023
130B cell receptor signaling pathway_Homo sapiens_hsa046620.25623728
131Platelet activation_Homo sapiens_hsa046110.25543835
132Vitamin B6 metabolism_Homo sapiens_hsa007500.24153201
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23268645
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19824939
135AMPK signaling pathway_Homo sapiens_hsa041520.18335512
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.17449571
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.16893184
138Autoimmune thyroid disease_Homo sapiens_hsa053200.16293065
139Renal cell carcinoma_Homo sapiens_hsa052110.16258465
140Biosynthesis of amino acids_Homo sapiens_hsa012300.15972828

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