USP9X

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.37951733
2protein complex localization (GO:0031503)5.09749289
3nuclear pore organization (GO:0006999)4.88651990
4DNA synthesis involved in DNA repair (GO:0000731)4.82902749
5synapsis (GO:0007129)4.50752133
6DNA unwinding involved in DNA replication (GO:0006268)4.33875697
7pre-miRNA processing (GO:0031054)4.19908311
8mitotic sister chromatid cohesion (GO:0007064)4.18733957
9cytoplasmic mRNA processing body assembly (GO:0033962)4.11506273
10negative regulation of histone methylation (GO:0031061)3.92631251
11Golgi transport vesicle coating (GO:0048200)3.91319967
12COPI coating of Golgi vesicle (GO:0048205)3.91319967
13regulation of protein polyubiquitination (GO:1902914)3.88300555
14regulation of gene silencing (GO:0060968)3.87452961
15regulation of RNA export from nucleus (GO:0046831)3.75158193
16histone H2A monoubiquitination (GO:0035518)3.73959698
17pore complex assembly (GO:0046931)3.68382200
18protein localization to kinetochore (GO:0034501)3.66861471
19chromosome organization involved in meiosis (GO:0070192)3.57178849
20protein localization to chromosome, centromeric region (GO:0071459)3.52124106
21cellular protein complex localization (GO:0034629)3.51276402
22regulation of chromatin silencing (GO:0031935)3.49129677
23stress granule assembly (GO:0034063)3.47254307
24histone H3-K9 demethylation (GO:0033169)3.45326166
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39270034
26NLS-bearing protein import into nucleus (GO:0006607)3.38992752
27glucocorticoid receptor signaling pathway (GO:0042921)3.34100409
28DNA duplex unwinding (GO:0032508)3.33651622
29negative regulation of gene silencing (GO:0060969)3.32360221
30glomerular visceral epithelial cell development (GO:0072015)3.30495698
31macroautophagy (GO:0016236)3.29801897
32negative regulation of chromosome segregation (GO:0051985)3.28455150
33negative regulation of DNA repair (GO:0045738)3.28292108
34negative regulation of mitotic sister chromatid separation (GO:2000816)3.27567160
35negative regulation of sister chromatid segregation (GO:0033046)3.27567160
36negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.27567160
37negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27567160
38negative regulation of mitotic sister chromatid segregation (GO:0033048)3.27567160
39positive regulation of histone methylation (GO:0031062)3.27394640
40regulation of DNA endoreduplication (GO:0032875)3.25732025
41regulation of nucleobase-containing compound transport (GO:0032239)3.23692931
42peptidyl-lysine dimethylation (GO:0018027)3.22808582
43positive regulation of histone H3-K4 methylation (GO:0051571)3.22721157
44regulation of chromosome segregation (GO:0051983)3.21842122
45regulation of mitotic sister chromatid separation (GO:0010965)3.20158927
46regulation of mitotic sister chromatid segregation (GO:0033047)3.20158927
47regulation of sister chromatid segregation (GO:0033045)3.20158927
48DNA geometric change (GO:0032392)3.20113466
49non-recombinational repair (GO:0000726)3.18014094
50double-strand break repair via nonhomologous end joining (GO:0006303)3.18014094
51regulation of NFAT protein import into nucleus (GO:0051532)3.17845450
52positive regulation of chromosome segregation (GO:0051984)3.16898287
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14719693
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14719693
55mitotic chromosome condensation (GO:0007076)3.07927595
56mitotic spindle checkpoint (GO:0071174)3.07353248
57histone lysine demethylation (GO:0070076)3.05219941
58establishment of integrated proviral latency (GO:0075713)3.05078470
59spindle checkpoint (GO:0031577)3.05071267
60dosage compensation (GO:0007549)3.03646329
61regulation of cell fate specification (GO:0042659)3.02644562
62mitotic spindle assembly checkpoint (GO:0007094)3.02408985
63DNA replication initiation (GO:0006270)3.02391634
64mitotic sister chromatid segregation (GO:0000070)2.99815398
65dorsal/ventral axis specification (GO:0009950)2.99654361
66protein targeting to Golgi (GO:0000042)2.98741550
67regulation of histone H3-K9 methylation (GO:0051570)2.98200242
68positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96448487
69positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96448487
70positive regulation of mitotic sister chromatid separation (GO:1901970)2.96448487
71spindle assembly checkpoint (GO:0071173)2.94793129
72synaptonemal complex assembly (GO:0007130)2.92790058
73corticosteroid receptor signaling pathway (GO:0031958)2.90382982
74regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.89643269
75protein localization to chromosome (GO:0034502)2.89382950
76regulation of histone methylation (GO:0031060)2.88000500
77regulation of SMAD protein import into nucleus (GO:0060390)2.86807520
78mitotic metaphase plate congression (GO:0007080)2.86236310
79meiotic chromosome segregation (GO:0045132)2.84980321
80histone demethylation (GO:0016577)2.83930119
81establishment of protein localization to Golgi (GO:0072600)2.82859161
82regulation of meiosis I (GO:0060631)2.81818807
83insulin-like growth factor receptor signaling pathway (GO:0048009)2.81746073
84establishment of nucleus localization (GO:0040023)2.81542645
85glomerular epithelial cell development (GO:0072310)2.81157244
86regulation of sister chromatid cohesion (GO:0007063)2.81093431
87protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.80965891
88anterior/posterior axis specification, embryo (GO:0008595)2.80559354
89positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.78278724
90monoubiquitinated protein deubiquitination (GO:0035520)2.78185637
91regulation of clathrin-mediated endocytosis (GO:2000369)2.76493967
92chromatin silencing (GO:0006342)2.76063234
93genitalia morphogenesis (GO:0035112)2.75884144
94regulation of translational termination (GO:0006449)2.75515689
95negative regulation of histone modification (GO:0031057)2.75388351
96intestinal epithelial cell development (GO:0060576)2.73785444
97lung-associated mesenchyme development (GO:0060484)2.73741381
98interkinetic nuclear migration (GO:0022027)2.73160924
99retrograde transport, vesicle recycling within Golgi (GO:0000301)2.70294572
100hippo signaling (GO:0035329)2.69927408
101ATP-dependent chromatin remodeling (GO:0043044)2.69779507
102regulation of DNA methylation (GO:0044030)2.69624630
103spindle assembly involved in mitosis (GO:0090307)2.67893730
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67572917
105negative regulation of chromatin modification (GO:1903309)2.67452776
106regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.65582985
107regulation of gene silencing by miRNA (GO:0060964)2.64788658
108regulation of gene silencing by RNA (GO:0060966)2.64788658
109regulation of posttranscriptional gene silencing (GO:0060147)2.64788658
110negative regulation of fibroblast apoptotic process (GO:2000270)2.64752518
111DNA strand elongation involved in DNA replication (GO:0006271)2.64616729
112vesicle coating (GO:0006901)2.64011337
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.63176140
114DNA conformation change (GO:0071103)2.63048071
115regulation of histone H3-K4 methylation (GO:0051569)2.60653217
116protein dealkylation (GO:0008214)2.60429490
117protein demethylation (GO:0006482)2.60429490
118metaphase plate congression (GO:0051310)2.60320293
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58762098
120layer formation in cerebral cortex (GO:0021819)2.58549348
121regulation of centriole replication (GO:0046599)2.58024324
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.56365890
123paraxial mesoderm development (GO:0048339)2.55453485
124gene silencing by RNA (GO:0031047)2.54652446
125histone H4-K12 acetylation (GO:0043983)2.53785874
126positive regulation of catenin import into nucleus (GO:0035413)2.53710761
127negative regulation of hormone metabolic process (GO:0032351)2.53616982
128negative regulation of hormone biosynthetic process (GO:0032353)2.53616982
129ectodermal placode formation (GO:0060788)2.52823560
130nucleus localization (GO:0051647)2.52485807
131microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.51735953
132histone H3-K36 demethylation (GO:0070544)2.51166562
133regulation of translational fidelity (GO:0006450)2.47173618
134COPII vesicle coating (GO:0048208)2.47075489
135regulation of mitotic spindle organization (GO:0060236)2.46889545
136positive regulation of nuclease activity (GO:0032075)2.45307108
137histone H2A ubiquitination (GO:0033522)2.43298168
138vesicle transport along microtubule (GO:0047496)2.43256445
139positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.42831198
140gastrulation with mouth forming second (GO:0001702)2.42662154
141membrane disassembly (GO:0030397)2.41788426
142nuclear envelope disassembly (GO:0051081)2.41788426
143sister chromatid segregation (GO:0000819)2.41509860
144inner ear receptor cell development (GO:0060119)2.41441721
145negative regulation of organelle assembly (GO:1902116)2.36275842
146histone H4-K8 acetylation (GO:0043982)2.35970049
147histone H4-K5 acetylation (GO:0043981)2.35970049
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35765439
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.35765439
150regulation of translation, ncRNA-mediated (GO:0045974)2.35765439
151chromatin assembly (GO:0031497)2.35060698
152sister chromatid cohesion (GO:0007062)2.32295418
153oocyte development (GO:0048599)2.32112232
154positive regulation of hormone biosynthetic process (GO:0046886)2.32097985
155synaptic vesicle maturation (GO:0016188)2.30301207
156mitotic nuclear envelope disassembly (GO:0007077)2.29836447
157type B pancreatic cell development (GO:0003323)2.29353656
158cytoskeleton-dependent cytokinesis (GO:0061640)2.28126469
159embryonic foregut morphogenesis (GO:0048617)2.25114334
160L-alpha-amino acid transmembrane transport (GO:1902475)2.24731151
161regulation of nuclease activity (GO:0032069)2.24167438
162heterochromatin organization (GO:0070828)2.23995646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.22035944
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.70067405
3E2F7_22180533_ChIP-Seq_HELA_Human4.69455417
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.06323371
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.00758323
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.94108370
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.78097490
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62851391
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55960634
10* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.54611846
11TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.48331818
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.38176848
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.34611263
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33448217
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12796482
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.07741203
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04769125
18POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93557838
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83838117
20* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81272595
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77982099
22* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.75995163
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.75121066
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72049210
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69315492
26PKCTHETA_26484144_Chip-Seq_BREAST_Human1.64892708
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61170543
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.60511777
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59814639
30* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58823378
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56337444
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53508544
33NANOG_16153702_ChIP-ChIP_HESCs_Human1.52681855
34TBX3_20139965_ChIP-Seq_MESCs_Mouse1.45165193
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.45052834
36TBX3_20139965_ChIP-Seq_ESCs_Mouse1.43582895
37NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40889030
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.40215933
39SOX2_16153702_ChIP-ChIP_HESCs_Human1.39836177
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39779617
41STAT3_23295773_ChIP-Seq_U87_Human1.38761645
42IGF1R_20145208_ChIP-Seq_DFB_Human1.36400852
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36176570
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36041092
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34435490
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33935557
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33398400
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31927508
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30318751
50SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.29753128
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29629236
52EWS_26573619_Chip-Seq_HEK293_Human1.28266011
53POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.27902155
54CLOCK_20551151_ChIP-Seq_293T_Human1.27761759
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27708923
56YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27672197
57* TP53_16413492_ChIP-PET_HCT116_Human1.26808292
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.25154551
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25111663
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.22867299
61* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21012891
62* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20527279
63BRD4_25478319_ChIP-Seq_HGPS_Human1.19609437
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.18270541
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18073784
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18033562
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18033562
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18033562
69* ISL1_27105846_Chip-Seq_CPCs_Mouse1.17118827
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.16875709
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16345006
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15956028
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.15257144
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.15020615
75SMAD4_21799915_ChIP-Seq_A2780_Human1.14153014
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13222961
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13127097
78AHR_22903824_ChIP-Seq_MCF-7_Human1.12128769
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12047443
80STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11998950
81AR_19668381_ChIP-Seq_PC3_Human1.11528448
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11258154
83SOX9_26525672_Chip-Seq_HEART_Mouse1.10453142
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.10393169
85TAF15_26573619_Chip-Seq_HEK293_Human1.09109123
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08557569
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08378971
88* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07974190
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.07671691
90* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06937774
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06851480
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.05233109
93FUS_26573619_Chip-Seq_HEK293_Human1.04149989
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03803103
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03711596
96* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03435200
97P300_19829295_ChIP-Seq_ESCs_Human1.03269864
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02516923
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.01614850
100TCF4_23295773_ChIP-Seq_U87_Human1.01210536
101GBX2_23144817_ChIP-Seq_PC3_Human1.01199726
102AR_21909140_ChIP-Seq_LNCAP_Human1.00450824
103BCAT_22108803_ChIP-Seq_LS180_Human0.98092758
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97636170
105NANOG_16518401_ChIP-PET_MESCs_Mouse0.97120769
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95175925
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95105730
108GATA1_22025678_ChIP-Seq_K562_Human0.95100396
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94913825
110* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94322365
111* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94153234
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.92641581
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.92475841
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92118711
115* CHD1_26751641_Chip-Seq_LNCaP_Human0.91279754
116ZNF263_19887448_ChIP-Seq_K562_Human0.91029418
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.90086467
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90063048
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89244733
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88052446
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87935140
122* RARB_27405468_Chip-Seq_BRAIN_Mouse0.87785668
123ELK1_19687146_ChIP-ChIP_HELA_Human0.86090874
124* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85993736
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85990080
126* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85403189
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85227558
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85159674
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85066366
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84857754
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84857754
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84815064
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84693222
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82264515
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81090740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.06058952
2MP0002877_abnormal_melanocyte_morpholog3.73502169
3MP0010234_abnormal_vibrissa_follicle3.30652042
4MP0000569_abnormal_digit_pigmentation3.23202523
5MP0003283_abnormal_digestive_organ3.04801326
6MP0010352_gastrointestinal_tract_polyps3.00994936
7MP0009780_abnormal_chondrocyte_physiolo2.86561983
8MP0003705_abnormal_hypodermis_morpholog2.79770532
9MP0005076_abnormal_cell_differentiation2.78920230
10MP0003693_abnormal_embryo_hatching2.73256655
11MP0003121_genomic_imprinting2.60784248
12MP0003787_abnormal_imprinting2.59898969
13MP0003890_abnormal_embryonic-extraembry2.57373583
14MP0010307_abnormal_tumor_latency2.32886670
15MP0003123_paternal_imprinting2.23384152
16MP0002254_reproductive_system_inflammat2.10179668
17MP0008058_abnormal_DNA_repair1.97596995
18MP0004264_abnormal_extraembryonic_tissu1.97594743
19MP0005187_abnormal_penis_morphology1.96213614
20MP0001299_abnormal_eye_distance/1.85226347
21MP0003122_maternal_imprinting1.80748495
22MP0008932_abnormal_embryonic_tissue1.77717569
23MP0002909_abnormal_adrenal_gland1.74781805
24* MP0002084_abnormal_developmental_patter1.73041915
25MP0008877_abnormal_DNA_methylation1.72305767
26MP0003300_gastrointestinal_ulcer1.67547182
27MP0000013_abnormal_adipose_tissue1.66570366
28MP0001661_extended_life_span1.66326332
29MP0000537_abnormal_urethra_morphology1.63887982
30MP0003119_abnormal_digestive_system1.61164468
31MP0008007_abnormal_cellular_replicative1.55888824
32MP0002009_preneoplasia1.55436715
33MP0009697_abnormal_copulation1.55190618
34MP0009703_decreased_birth_body1.51992788
35MP0000003_abnormal_adipose_tissue1.49740690
36MP0005248_abnormal_Harderian_gland1.48917275
37MP0004197_abnormal_fetal_growth/weight/1.48086567
38MP0001730_embryonic_growth_arrest1.44860610
39MP0000383_abnormal_hair_follicle1.43496292
40MP0005409_darkened_coat_color1.39310668
41* MP0002086_abnormal_extraembryonic_tissu1.38266207
42MP0004185_abnormal_adipocyte_glucose1.37730593
43MP0001672_abnormal_embryogenesis/_devel1.34370386
44MP0005380_embryogenesis_phenotype1.34370386
45MP0003045_fibrosis1.34115064
46MP0005623_abnormal_meninges_morphology1.33720611
47MP0003718_maternal_effect1.33175261
48MP0000579_abnormal_nail_morphology1.31161562
49* MP0002085_abnormal_embryonic_tissue1.30700969
50MP0004270_analgesia1.30505126
51MP0002896_abnormal_bone_mineralization1.26588645
52MP0002088_abnormal_embryonic_growth/wei1.26515427
53MP0001944_abnormal_pancreas_morphology1.26288071
54MP0003984_embryonic_growth_retardation1.25491630
55MP0008961_abnormal_basal_metabolism1.24584044
56MP0003937_abnormal_limbs/digits/tail_de1.23601158
57MP0009672_abnormal_birth_weight1.21825436
58MP0001849_ear_inflammation1.21566655
59MP0005367_renal/urinary_system_phenotyp1.20716602
60MP0000516_abnormal_urinary_system1.20716602
61MP0000350_abnormal_cell_proliferation1.20124265
62MP0001188_hyperpigmentation1.18953567
63MP0003566_abnormal_cell_adhesion1.18860497
64MP0003091_abnormal_cell_migration1.18497256
65MP0003935_abnormal_craniofacial_develop1.18075916
66MP0000428_abnormal_craniofacial_morphol1.17939359
67MP0006072_abnormal_retinal_apoptosis1.14811082
68* MP0001697_abnormal_embryo_size1.12755414
69MP0009053_abnormal_anal_canal1.12168692
70MP0010030_abnormal_orbit_morphology1.09819329
71MP0004233_abnormal_muscle_weight1.08239447
72MP0010094_abnormal_chromosome_stability1.04903693
73MP0004859_abnormal_synaptic_plasticity1.04654528
74MP0002210_abnormal_sex_determination1.04179642
75MP0002233_abnormal_nose_morphology1.01959868
76MP0001286_abnormal_eye_development1.01382779
77MP0002653_abnormal_ependyma_morphology0.99797563
78MP0003077_abnormal_cell_cycle0.96523654
79MP0000733_abnormal_muscle_development0.95070608
80MP0008057_abnormal_DNA_replication0.94669012
81MP0002693_abnormal_pancreas_physiology0.94591417
82* MP0003861_abnormal_nervous_system0.94414020
83MP0003252_abnormal_bile_duct0.92794299
84MP0000462_abnormal_digestive_system0.92721449
85MP0005375_adipose_tissue_phenotype0.92081159
86MP0001293_anophthalmia0.91681018
87MP0004808_abnormal_hematopoietic_stem0.91182328
88MP0002697_abnormal_eye_size0.90112487
89MP0003115_abnormal_respiratory_system0.89980164
90MP0004885_abnormal_endolymph0.89145558
91MP0003453_abnormal_keratinocyte_physiol0.89082329
92MP0010630_abnormal_cardiac_muscle0.89021704
93MP0000534_abnormal_ureter_morphology0.88217361
94MP0008438_abnormal_cutaneous_collagen0.88001757
95MP0002168_other_aberrant_phenotype0.87568199
96MP0001145_abnormal_male_reproductive0.87414966
97MP0003111_abnormal_nucleus_morphology0.87265585
98MP0001929_abnormal_gametogenesis0.87001718
99MP0002928_abnormal_bile_duct0.86263130
100MP0003755_abnormal_palate_morphology0.86076868
101MP0002080_prenatal_lethality0.86050304
102MP0000647_abnormal_sebaceous_gland0.86002557
103MP0002234_abnormal_pharynx_morphology0.85225850
104MP0010678_abnormal_skin_adnexa0.84306120
105MP0004957_abnormal_blastocyst_morpholog0.84214021
106* MP0002925_abnormal_cardiovascular_devel0.84050719
107MP0003385_abnormal_body_wall0.83611559
108MP0003221_abnormal_cardiomyocyte_apopto0.82263346
109MP0004272_abnormal_basement_membrane0.82105306
110MP0002111_abnormal_tail_morphology0.81958509
111MP0000631_abnormal_neuroendocrine_gland0.81474603
112MP0000432_abnormal_head_morphology0.80921872
113MP0000313_abnormal_cell_death0.79293412
114MP0003646_muscle_fatigue0.78485946
115MP0000427_abnormal_hair_cycle0.78204604
116MP0003136_yellow_coat_color0.77306073
117MP0002078_abnormal_glucose_homeostasis0.76322747
118MP0005666_abnormal_adipose_tissue0.76155801
119MP0005220_abnormal_exocrine_pancreas0.74937068
120MP0001177_atelectasis0.74813501
121MP0003943_abnormal_hepatobiliary_system0.74277464
122MP0000653_abnormal_sex_gland0.73072462
123MP0000371_diluted_coat_color0.73019977
124MP0008770_decreased_survivor_rate0.72798510
125MP0001915_intracranial_hemorrhage0.72322011
126MP0004043_abnormal_pH_regulation0.70977707
127MP0004084_abnormal_cardiac_muscle0.70821182
128MP0005621_abnormal_cell_physiology0.70797202
129MP0002269_muscular_atrophy0.70708805
130MP0002160_abnormal_reproductive_system0.70409280
131MP0002114_abnormal_axial_skeleton0.69677777
132MP0002092_abnormal_eye_morphology0.69467453
133MP0000377_abnormal_hair_follicle0.69458269
134MP0000778_abnormal_nervous_system0.69301781
135MP0003567_abnormal_fetal_cardiomyocyte0.69085622
136MP0002796_impaired_skin_barrier0.68472310
137MP0005275_abnormal_skin_tensile0.68452351
138* MP0000266_abnormal_heart_morphology0.68169623
139MP0002081_perinatal_lethality0.67997322
140MP0004036_abnormal_muscle_relaxation0.67529757
141MP0002152_abnormal_brain_morphology0.66369074
142MP0000762_abnormal_tongue_morphology0.66217760
143MP0006054_spinal_hemorrhage0.65818401

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.79140339
2Nephroblastoma (Wilms tumor) (HP:0002667)3.70215334
3Embryonal renal neoplasm (HP:0011794)3.53597627
4Macroorchidism (HP:0000053)3.48294948
5Astrocytoma (HP:0009592)3.41771163
6Abnormality of the astrocytes (HP:0100707)3.41771163
7Spastic diplegia (HP:0001264)3.36480579
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16370725
9Volvulus (HP:0002580)3.15265970
10Ependymoma (HP:0002888)3.14161774
11Chromsome breakage (HP:0040012)3.11918693
12Shoulder girdle muscle weakness (HP:0003547)2.76059137
13Abnormality of the labia minora (HP:0012880)2.72611723
14Cortical dysplasia (HP:0002539)2.68460271
15Protruding tongue (HP:0010808)2.65906477
16Glioma (HP:0009733)2.62653368
17Biliary tract neoplasm (HP:0100574)2.60782869
18Vertebral arch anomaly (HP:0008438)2.60714781
19Aplasia/Hypoplasia of the sternum (HP:0006714)2.59429897
20Subacute progressive viral hepatitis (HP:0006572)2.57471553
21Neoplasm of the oral cavity (HP:0100649)2.57403380
22Heterotopia (HP:0002282)2.55295637
23Truncal obesity (HP:0001956)2.50053112
24Deep philtrum (HP:0002002)2.49937470
25Rimmed vacuoles (HP:0003805)2.47148786
26Hyperglycemia (HP:0003074)2.42859629
27Neonatal hypoglycemia (HP:0001998)2.42643646
28Hyperinsulinemic hypoglycemia (HP:0000825)2.41300820
29Chronic bronchitis (HP:0004469)2.41169695
30Thyroid carcinoma (HP:0002890)2.40748270
31Hypoglycemic seizures (HP:0002173)2.39219185
32Cerebral aneurysm (HP:0004944)2.36181793
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33388547
34Termporal pattern (HP:0011008)2.25263619
35Insidious onset (HP:0003587)2.25263619
36Enlarged penis (HP:0000040)2.25054076
37Abnormality of the lower motor neuron (HP:0002366)2.24598105
38Insulin-resistant diabetes mellitus (HP:0000831)2.23339170
39Ectopic kidney (HP:0000086)2.19971419
40Hypoplastic labia majora (HP:0000059)2.17555146
41Sandal gap (HP:0001852)2.16664768
42Embryonal neoplasm (HP:0002898)2.16531451
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14150715
44Short 4th metacarpal (HP:0010044)2.14150715
45Resting tremor (HP:0002322)2.12789799
46Selective tooth agenesis (HP:0001592)2.11082496
47Dysmetric saccades (HP:0000641)2.10554638
48Gastrointestinal carcinoma (HP:0002672)2.08029280
49Malignant gastrointestinal tract tumors (HP:0006749)2.08029280
50Abnormality of chromosome stability (HP:0003220)2.07252279
51Colon cancer (HP:0003003)2.05971907
52Shawl scrotum (HP:0000049)2.05934010
53Bowel diverticulosis (HP:0005222)2.03798610
54High anterior hairline (HP:0009890)2.03153909
55Choanal stenosis (HP:0000452)2.02785429
56Hepatoblastoma (HP:0002884)2.02734510
57Medulloblastoma (HP:0002885)2.01609914
58Shallow orbits (HP:0000586)2.01306279
59Obsessive-compulsive behavior (HP:0000722)2.01202827
60Missing ribs (HP:0000921)1.99975466
61Abnormality of the labia majora (HP:0012881)1.93027058
62Hand muscle atrophy (HP:0009130)1.92962971
63Proximal placement of thumb (HP:0009623)1.92720274
64Papilledema (HP:0001085)1.91102399
65Transitional cell carcinoma of the bladder (HP:0006740)1.90868304
66Rhabdomyosarcoma (HP:0002859)1.90167321
67Narrow palate (HP:0000189)1.89318431
68Abnormal lung lobation (HP:0002101)1.88490149
69Renovascular hypertension (HP:0100817)1.88315159
70Facial hemangioma (HP:0000329)1.88202660
71Pelvic girdle muscle weakness (HP:0003749)1.86859971
72Absent radius (HP:0003974)1.86531047
73Skull defect (HP:0001362)1.85700920
74Hypopigmentation of the fundus (HP:0007894)1.85658327
75Overgrowth (HP:0001548)1.84613616
76Capillary hemangiomas (HP:0005306)1.84171030
77Cutaneous syndactyly (HP:0012725)1.83604129
78Bladder carcinoma (HP:0002862)1.83001556
79Bladder neoplasm (HP:0009725)1.83001556
80Exercise-induced muscle cramps (HP:0003710)1.82807599
81Abnormality of the distal phalanx of the thumb (HP:0009617)1.81665304
82Neoplasm of the adrenal cortex (HP:0100641)1.81439165
83Abnormal biliary tract morphology (HP:0012440)1.81321257
84Omphalocele (HP:0001539)1.81223276
85Ankyloglossia (HP:0010296)1.78999135
86Neoplasm of the colon (HP:0100273)1.78774462
87Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78691769
88Excessive salivation (HP:0003781)1.78557724
89Drooling (HP:0002307)1.78557724
90Diastasis recti (HP:0001540)1.77038996
91Gonadotropin excess (HP:0000837)1.76735849
92Aneurysm (HP:0002617)1.75768017
93Abnormality of the fingertips (HP:0001211)1.74513324
942-3 toe syndactyly (HP:0004691)1.74423706
95Ankle contracture (HP:0006466)1.74182156
96Urethral obstruction (HP:0000796)1.73581643
97Neoplasm of the thyroid gland (HP:0100031)1.73421381
98Right ventricular cardiomyopathy (HP:0011663)1.71518056
99Aqueductal stenosis (HP:0002410)1.70974717
100Cutaneous finger syndactyly (HP:0010554)1.70835770
101Neoplasm of striated muscle (HP:0009728)1.70575394
102Abnormality of the salivary glands (HP:0010286)1.70380842
103Abnormality of the calcaneus (HP:0008364)1.69369467
104Symptomatic seizures (HP:0011145)1.69274368
105Hypoplastic ischia (HP:0003175)1.69211143
106Short humerus (HP:0005792)1.69039106
107Large hands (HP:0001176)1.68691291
108Abnormality of chromosome segregation (HP:0002916)1.68559567
109Fibrous tissue neoplasm (HP:0012316)1.68325356
110Abnormal hair whorl (HP:0010721)1.67853680
111Absent eyebrow (HP:0002223)1.67253880
112Intestinal polyposis (HP:0200008)1.67123421
113Absent forearm bone (HP:0003953)1.67021052
114Aplasia involving forearm bones (HP:0009822)1.67021052
115Acute myeloid leukemia (HP:0004808)1.66945686
116Long foot (HP:0001833)1.66241582
117Flat face (HP:0012368)1.65538953
118Hyperacusis (HP:0010780)1.65092356
119Fibroma (HP:0010614)1.64832973
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64804586
121Elfin facies (HP:0004428)1.64566037
122Abnormality of the ischium (HP:0003174)1.64460304
123Progressive external ophthalmoplegia (HP:0000590)1.64391813
124Duplication of thumb phalanx (HP:0009942)1.64006863
125Aplasia involving bones of the upper limbs (HP:0009823)1.63597375
126Aplasia of the phalanges of the hand (HP:0009802)1.63597375
127Aplasia involving bones of the extremities (HP:0009825)1.63597375
128Uterine neoplasm (HP:0010784)1.63475537
129Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63419191
130Short 1st metacarpal (HP:0010034)1.63419191
131Increased nuchal translucency (HP:0010880)1.63074000
132Lip pit (HP:0100267)1.62933034
133Neoplasm of the small intestine (HP:0100833)1.62761072
134Osteomalacia (HP:0002749)1.62285588
135Long eyelashes (HP:0000527)1.62155446
136Abnormality of the musculature of the pelvis (HP:0001469)1.61917659
137Abnormality of the hip-girdle musculature (HP:0001445)1.61917659
138Deviation of the thumb (HP:0009603)1.61512938
139Impaired smooth pursuit (HP:0007772)1.60437408
140Striae distensae (HP:0001065)1.60164982
141Birth length less than 3rd percentile (HP:0003561)1.59967873
142Relative macrocephaly (HP:0004482)1.59001747
143Hypospadias (HP:0000047)1.58614696
144Abnormality of the septum pellucidum (HP:0007375)1.58055995
145Genetic anticipation (HP:0003743)1.57993279
146Urinary bladder sphincter dysfunction (HP:0002839)1.57835753
147Lymphangioma (HP:0100764)1.57405412
148Intestinal polyp (HP:0005266)1.57060292
149Abnormality of the 4th metacarpal (HP:0010012)1.56766353
150Labial hypoplasia (HP:0000066)1.56759666
151Pancreatic islet-cell hyperplasia (HP:0004510)1.55828798
152Absent frontal sinuses (HP:0002688)1.55525553
153Uterine leiomyosarcoma (HP:0002891)1.55090404
154Leiomyosarcoma (HP:0100243)1.55090404
155Prominent nose (HP:0000448)1.54965204
156Distal upper limb amyotrophy (HP:0007149)1.54728783
157Upper limb amyotrophy (HP:0009129)1.54728783
158Abnormality of the diencephalon (HP:0010662)1.53994177
159Hypoplasia of the maxilla (HP:0000327)1.53820095
160Agitation (HP:0000713)1.51948819
161Delayed puberty (HP:0000823)1.51550026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.09268966
2CDK123.39869883
3SCYL22.97348266
4MAP3K102.81730501
5FRK2.65851018
6TSSK62.54221464
7TAF12.25409352
8MAP3K22.14441266
9PDGFRA2.14269961
10MAP3K92.05815503
11CDC72.03045493
12WNK31.93142656
13CAMK1D1.92526770
14PRKD31.91896172
15CASK1.80563565
16LATS21.79773901
17MAP3K41.77157188
18PASK1.69357174
19CDK191.68140010
20INSRR1.64871823
21BMX1.64105449
22PKN21.61945562
23SRPK11.60871212
24FGFR21.57724251
25MKNK21.56072306
26CAMK1G1.53272768
27KSR11.52096439
28TAOK31.50287082
29NEK11.49614617
30AKT31.48649736
31NLK1.48242622
32NTRK31.47382918
33RIPK11.45684256
34KSR21.45233316
35MKNK11.43666822
36RET1.42819065
37BRD41.42193100
38YES11.32291746
39FGFR31.25976117
40PLK41.25337659
41STK31.24561986
42MTOR1.22973121
43PBK1.19911528
44STK241.18723682
45EEF2K1.17804111
46OBSCN1.17628355
47TYRO31.15049004
48PNCK1.11789680
49SMG11.08109473
50DYRK31.07413236
51PDGFRB1.07022303
52PAK61.06022219
53ALK1.02574512
54WEE11.01172261
55FER1.00450554
56NTRK11.00350774
57MARK11.00144009
58PTK60.97085137
59MELK0.96842652
60STK38L0.96751843
61PAK30.94818781
62TRIB30.94750702
63ERBB40.94621781
64MET0.94236364
65TTN0.92645937
66FGR0.89663272
67ATM0.89085295
68DDR20.88957008
69TNIK0.88872631
70CDK60.88457507
71FLT30.88094211
72FGFR10.88037874
73TTK0.86892355
74SGK30.86049108
75EPHA20.85872349
76STK380.84572728
77PTK20.83088804
78ZAK0.82769015
79NEK20.82172377
80CHEK20.81090224
81WNK10.80288180
82CHEK10.79730421
83SGK20.78553019
84HIPK20.77598212
85CDC42BPA0.77585405
86CSNK1D0.74040083
87BCR0.73569399
88PLK30.73101691
89CDK90.72498207
90SIK10.69422191
91PRKAA10.69400526
92PLK20.69276842
93OXSR10.68243480
94DMPK0.66179512
95ERBB30.66129850
96NTRK20.64861367
97FGFR40.64282619
98PRKCH0.64098307
99BUB10.64072992
100MAPK100.63440770
101NEK90.63204185
102MINK10.62813710
103AURKB0.60173585
104CDK20.59909754
105CDK70.59653080
106ATR0.59052366
107CDK40.58397902
108MAP2K40.58240900
109BRSK20.58076166
110PRKDC0.57241012
111RPS6KB20.55091633
112CSNK1E0.54426810
113MAPK140.54265406
114PIM10.54242206
115CDK10.52694263
116SGK10.52688030
117CAMKK10.51743363
118CSNK1G20.50971276
119NUAK10.50417771
120GSK3B0.47982180
121DYRK1A0.47751586
122RPS6KB10.47406468
123CSNK1G10.47092649
124EPHA30.46965962
125STK40.46787892
126BRAF0.46708316
127CSNK1A1L0.45736790
128CDK30.45541241
129NEK60.45093924
130RPS6KA30.44913441
131ICK0.43049975
132MAP3K60.42098466
133ACVR1B0.41017277
134PLK10.39686846
135SGK4940.39204048
136SGK2230.39204048

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.25264122
2DNA replication_Homo sapiens_hsa030302.58400962
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.37778037
4Mismatch repair_Homo sapiens_hsa034302.36566943
5Type II diabetes mellitus_Homo sapiens_hsa049302.16533786
6mTOR signaling pathway_Homo sapiens_hsa041501.97235980
7Nitrogen metabolism_Homo sapiens_hsa009101.94958260
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83578005
9Cysteine and methionine metabolism_Homo sapiens_hsa002701.79888350
10Dorso-ventral axis formation_Homo sapiens_hsa043201.75836342
11Insulin secretion_Homo sapiens_hsa049111.66632027
12Endometrial cancer_Homo sapiens_hsa052131.57073011
13Adherens junction_Homo sapiens_hsa045201.56188499
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49859232
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49211837
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48690018
17Lysine degradation_Homo sapiens_hsa003101.41941693
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41563423
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.40664307
20MicroRNAs in cancer_Homo sapiens_hsa052061.40609571
21Nucleotide excision repair_Homo sapiens_hsa034201.39465768
22Fanconi anemia pathway_Homo sapiens_hsa034601.35209536
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34476747
24Glioma_Homo sapiens_hsa052141.34432217
25Long-term potentiation_Homo sapiens_hsa047201.32637252
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31410149
27Estrogen signaling pathway_Homo sapiens_hsa049151.31170845
28Hippo signaling pathway_Homo sapiens_hsa043901.26708715
29Alcoholism_Homo sapiens_hsa050341.24259612
30Colorectal cancer_Homo sapiens_hsa052101.23844351
31Oocyte meiosis_Homo sapiens_hsa041141.19970863
32Spliceosome_Homo sapiens_hsa030401.19146836
33Glucagon signaling pathway_Homo sapiens_hsa049221.17723337
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15838843
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.14159512
36Insulin resistance_Homo sapiens_hsa049311.14061684
37TGF-beta signaling pathway_Homo sapiens_hsa043501.13863633
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13609085
39Proteoglycans in cancer_Homo sapiens_hsa052051.11512056
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10354583
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10131014
42Chronic myeloid leukemia_Homo sapiens_hsa052201.08649995
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08308319
44Insulin signaling pathway_Homo sapiens_hsa049101.08051756
45Focal adhesion_Homo sapiens_hsa045101.07693576
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07248466
47Systemic lupus erythematosus_Homo sapiens_hsa053221.06746071
48Prolactin signaling pathway_Homo sapiens_hsa049171.06173671
49Renal cell carcinoma_Homo sapiens_hsa052111.06025816
50Basal transcription factors_Homo sapiens_hsa030221.05715822
51Homologous recombination_Homo sapiens_hsa034401.04973010
52ErbB signaling pathway_Homo sapiens_hsa040121.04738956
53Dopaminergic synapse_Homo sapiens_hsa047281.04315371
54One carbon pool by folate_Homo sapiens_hsa006701.01782510
55Prostate cancer_Homo sapiens_hsa052151.00718386
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00413716
57RNA degradation_Homo sapiens_hsa030180.99082056
58Cell cycle_Homo sapiens_hsa041100.98717861
59Thyroid cancer_Homo sapiens_hsa052160.98671107
60Non-small cell lung cancer_Homo sapiens_hsa052230.98347358
61Tight junction_Homo sapiens_hsa045300.98122995
62p53 signaling pathway_Homo sapiens_hsa041150.97336666
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96126586
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95048032
65Thyroid hormone synthesis_Homo sapiens_hsa049180.93707612
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93528194
67Amphetamine addiction_Homo sapiens_hsa050310.93379886
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.92774801
69FoxO signaling pathway_Homo sapiens_hsa040680.92575720
70Pancreatic cancer_Homo sapiens_hsa052120.92220277
71AMPK signaling pathway_Homo sapiens_hsa041520.92030795
72mRNA surveillance pathway_Homo sapiens_hsa030150.91885037
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90992816
74Base excision repair_Homo sapiens_hsa034100.88542267
75Viral carcinogenesis_Homo sapiens_hsa052030.87455693
76GnRH signaling pathway_Homo sapiens_hsa049120.87442619
77Inositol phosphate metabolism_Homo sapiens_hsa005620.87415924
78Gap junction_Homo sapiens_hsa045400.86436807
79Wnt signaling pathway_Homo sapiens_hsa043100.85809384
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84662223
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84575257
82Circadian rhythm_Homo sapiens_hsa047100.84017967
83Melanogenesis_Homo sapiens_hsa049160.83861842
84Cholinergic synapse_Homo sapiens_hsa047250.83777551
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83490927
86Cocaine addiction_Homo sapiens_hsa050300.82711512
87Biosynthesis of amino acids_Homo sapiens_hsa012300.82390998
88Selenocompound metabolism_Homo sapiens_hsa004500.81198731
89Basal cell carcinoma_Homo sapiens_hsa052170.81070970
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79553305
91Circadian entrainment_Homo sapiens_hsa047130.78979790
92Hedgehog signaling pathway_Homo sapiens_hsa043400.78496872
93Small cell lung cancer_Homo sapiens_hsa052220.78235979
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77367029
95Choline metabolism in cancer_Homo sapiens_hsa052310.76548326
96Bladder cancer_Homo sapiens_hsa052190.76169696
97cAMP signaling pathway_Homo sapiens_hsa040240.75141829
98Renin secretion_Homo sapiens_hsa049240.73085122
99Melanoma_Homo sapiens_hsa052180.72410643
100Oxytocin signaling pathway_Homo sapiens_hsa049210.68342613
101ECM-receptor interaction_Homo sapiens_hsa045120.68171985
102GABAergic synapse_Homo sapiens_hsa047270.66155781
103Type I diabetes mellitus_Homo sapiens_hsa049400.65825668
104RNA transport_Homo sapiens_hsa030130.64060214
105Long-term depression_Homo sapiens_hsa047300.62966056
106Synaptic vesicle cycle_Homo sapiens_hsa047210.62866031
107Dilated cardiomyopathy_Homo sapiens_hsa054140.62199284
108Axon guidance_Homo sapiens_hsa043600.61998988
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60999218
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59892365
111Vitamin B6 metabolism_Homo sapiens_hsa007500.59444727
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.58920514
113Amoebiasis_Homo sapiens_hsa051460.58739916
114MAPK signaling pathway_Homo sapiens_hsa040100.58403482
115Rap1 signaling pathway_Homo sapiens_hsa040150.58282880
116Gastric acid secretion_Homo sapiens_hsa049710.57934009
117Pathways in cancer_Homo sapiens_hsa052000.57915820
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57381607
119Ovarian steroidogenesis_Homo sapiens_hsa049130.56881053
120Fatty acid biosynthesis_Homo sapiens_hsa000610.56850197
121VEGF signaling pathway_Homo sapiens_hsa043700.55795476
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53882425
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49495310
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48706112
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.47985503
126Pyruvate metabolism_Homo sapiens_hsa006200.47164074
127HTLV-I infection_Homo sapiens_hsa051660.41649862
128Renin-angiotensin system_Homo sapiens_hsa046140.39276876
129Arginine biosynthesis_Homo sapiens_hsa002200.37040826
130Acute myeloid leukemia_Homo sapiens_hsa052210.36669486

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