USP44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.83197839
2cell wall macromolecule metabolic process (GO:0044036)9.83197839
3fusion of sperm to egg plasma membrane (GO:0007342)9.57622091
4sperm-egg recognition (GO:0035036)8.77419172
5sperm motility (GO:0030317)8.76655818
6acrosome assembly (GO:0001675)8.19823822
7multicellular organism reproduction (GO:0032504)8.11359504
8cilium or flagellum-dependent cell motility (GO:0001539)7.98438211
9binding of sperm to zona pellucida (GO:0007339)7.91348082
10cell-cell recognition (GO:0009988)7.82356713
11acrosome reaction (GO:0007340)7.71680043
12motile cilium assembly (GO:0044458)7.24661321
13plasma membrane fusion (GO:0045026)7.22426839
14axonemal dynein complex assembly (GO:0070286)7.15234094
15epithelial cilium movement (GO:0003351)6.77010245
16spermatid development (GO:0007286)6.67719268
17reproduction (GO:0000003)6.58260036
18regulation of cilium movement (GO:0003352)6.07774965
19microtubule depolymerization (GO:0007019)5.96694506
20male meiosis (GO:0007140)5.69153729
21cilium movement (GO:0003341)5.65242040
22establishment of integrated proviral latency (GO:0075713)5.64181550
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.61525380
24piRNA metabolic process (GO:0034587)5.58800861
25regulation of posttranscriptional gene silencing (GO:0060147)5.32176725
26regulation of gene silencing by miRNA (GO:0060964)5.32176725
27regulation of gene silencing by RNA (GO:0060966)5.32176725
28single fertilization (GO:0007338)5.21731513
29synaptonemal complex assembly (GO:0007130)5.08784623
30synaptonemal complex organization (GO:0070193)5.03967211
31sperm capacitation (GO:0048240)4.73349753
32pre-miRNA processing (GO:0031054)4.61355923
33spermatogenesis (GO:0007283)4.51792778
34male gamete generation (GO:0048232)4.50879775
35regulation of helicase activity (GO:0051095)4.48234009
36IMP biosynthetic process (GO:0006188)4.42119772
37protein localization to kinetochore (GO:0034501)4.39833341
38L-serine metabolic process (GO:0006563)4.39282010
39fertilization (GO:0009566)4.32844162
40DNA methylation involved in gamete generation (GO:0043046)4.32670532
41DNA replication-independent nucleosome organization (GO:0034724)4.29672745
42DNA replication-independent nucleosome assembly (GO:0006336)4.29672745
43establishment of viral latency (GO:0019043)4.26290944
44DNA replication checkpoint (GO:0000076)4.25110030
45gamete generation (GO:0007276)4.15747625
46mitotic metaphase plate congression (GO:0007080)4.14024592
47negative regulation of DNA-dependent DNA replication (GO:2000104)4.13013042
48chromosome organization involved in meiosis (GO:0070192)4.11728001
49heterochromatin organization (GO:0070828)4.10186740
50nuclear pore complex assembly (GO:0051292)4.09158530
51purine nucleobase biosynthetic process (GO:0009113)4.05392085
52IMP metabolic process (GO:0046040)4.02705819
53nuclear pore organization (GO:0006999)3.96749059
54germ cell development (GO:0007281)3.95128826
55DNA packaging (GO:0006323)3.94063425
56chromosome condensation (GO:0030261)3.89377928
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.85510247
58histone exchange (GO:0043486)3.84593300
59meiotic nuclear division (GO:0007126)3.83834293
60spindle checkpoint (GO:0031577)3.83778725
61mitotic spindle checkpoint (GO:0071174)3.82566843
62regulation of centriole replication (GO:0046599)3.80594772
63DNA replication-dependent nucleosome organization (GO:0034723)3.77272666
64DNA replication-dependent nucleosome assembly (GO:0006335)3.77272666
65organic cation transport (GO:0015695)3.76421764
66DNA double-strand break processing (GO:0000729)3.73713837
67nucleobase biosynthetic process (GO:0046112)3.72031029
68negative regulation of translation, ncRNA-mediated (GO:0040033)3.71888758
69regulation of translation, ncRNA-mediated (GO:0045974)3.71888758
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.71888758
71* negative regulation of mitotic sister chromatid separation (GO:2000816)3.71810409
72* negative regulation of sister chromatid segregation (GO:0033046)3.71810409
73* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.71810409
74* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.71810409
75* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.71810409
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.66811352
77ventricular system development (GO:0021591)3.66295135
78* negative regulation of chromosome segregation (GO:0051985)3.65926115
79centriole assembly (GO:0098534)3.65832562
80mitotic spindle assembly checkpoint (GO:0007094)3.65126942
81telomere maintenance via telomerase (GO:0007004)3.64929347
82male meiosis I (GO:0007141)3.62239331
83cell recognition (GO:0008037)3.59819565
84spindle assembly checkpoint (GO:0071173)3.55957644
85metaphase plate congression (GO:0051310)3.53832883
86spermatid nucleus differentiation (GO:0007289)3.52212032
87single strand break repair (GO:0000012)3.51625277
88negative regulation of inclusion body assembly (GO:0090084)3.49677397
89chaperone-mediated protein complex assembly (GO:0051131)3.45801696
90ribosome assembly (GO:0042255)3.42095732
91regulation of cell fate specification (GO:0042659)3.41456551
92negative regulation of telomerase activity (GO:0051974)3.39949786
93negative regulation of DNA recombination (GO:0045910)3.39362647
94regulation of histone H3-K9 methylation (GO:0051570)3.38881750
95monoubiquitinated protein deubiquitination (GO:0035520)3.37252665
96DNA damage response, detection of DNA damage (GO:0042769)3.35806370
97* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31940109
98* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31940109
99chaperone-mediated protein transport (GO:0072321)3.31168390
100protein localization to chromosome, centromeric region (GO:0071459)3.26775709
101mitotic sister chromatid cohesion (GO:0007064)3.26406698
102mitotic G2/M transition checkpoint (GO:0044818)3.24973812
103centriole replication (GO:0007099)3.24557805
104* regulation of mitotic sister chromatid segregation (GO:0033047)3.24201155
105* regulation of sister chromatid segregation (GO:0033045)3.24201155
106* regulation of mitotic sister chromatid separation (GO:0010965)3.24201155
107multicellular organismal reproductive process (GO:0048609)3.22539386
108nucleus organization (GO:0006997)3.22164511
109response to X-ray (GO:0010165)3.21660559
110DNA unwinding involved in DNA replication (GO:0006268)3.21589276
111paraxial mesoderm development (GO:0048339)3.21506715
112chromatin remodeling at centromere (GO:0031055)3.20732154
113* regulation of chromosome segregation (GO:0051983)3.20457680
114positive regulation of SMAD protein import into nucleus (GO:0060391)3.20340252
115DNA replication initiation (GO:0006270)3.19535671
116regulation of inclusion body assembly (GO:0090083)3.18674546
117meiotic cell cycle (GO:0051321)3.18385367
118RNA-dependent DNA replication (GO:0006278)3.16729747
119regulation of microtubule-based movement (GO:0060632)3.16228986
120DNA ligation (GO:0006266)3.15971452
121regulation of telomere maintenance via telomerase (GO:0032210)3.15313599
122microtubule severing (GO:0051013)3.14772729
123microtubule polymerization or depolymerization (GO:0031109)3.13681277
124lysine metabolic process (GO:0006553)3.13501803
125lysine catabolic process (GO:0006554)3.13501803
126calcium ion-dependent exocytosis (GO:0017156)3.13332936
127pore complex assembly (GO:0046931)3.11451686
128synapsis (GO:0007129)3.09931146
129transcription elongation from RNA polymerase III promoter (GO:0006385)3.09511520
130termination of RNA polymerase III transcription (GO:0006386)3.09511520
131chromatin assembly or disassembly (GO:0006333)3.08585978
132non-recombinational repair (GO:0000726)3.08277153
133double-strand break repair via nonhomologous end joining (GO:0006303)3.08277153
134seminiferous tubule development (GO:0072520)3.07373182
135histone H2A acetylation (GO:0043968)3.06772210
136establishment of protein localization to mitochondrial membrane (GO:0090151)3.06768920
137meiosis I (GO:0007127)3.06252319
138mitotic recombination (GO:0006312)3.02964820
139kinetochore organization (GO:0051383)3.02617240
140translesion synthesis (GO:0019985)3.02589538
141telomere maintenance via telomere lengthening (GO:0010833)3.02458519
142* negative regulation of mitosis (GO:0045839)3.02241002
143telomere maintenance via recombination (GO:0000722)3.01525255
144proteasome assembly (GO:0043248)2.99435418
145meiotic cell cycle process (GO:1903046)2.98905828
146spliceosomal snRNP assembly (GO:0000387)2.98116996
147protein complex localization (GO:0031503)2.97594294
148protein K6-linked ubiquitination (GO:0085020)2.97301337
149regulation of gene silencing (GO:0060968)2.96157633
150protein-DNA complex disassembly (GO:0032986)2.96018791
151nucleosome disassembly (GO:0006337)2.96018791
152histone mRNA metabolic process (GO:0008334)2.95932477
153regulation of centrosome cycle (GO:0046605)2.94113888
154rRNA modification (GO:0000154)2.93772353
155mitotic sister chromatid segregation (GO:0000070)2.92462949
156regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90868415
157glycerol ether metabolic process (GO:0006662)2.90353332
158intra-S DNA damage checkpoint (GO:0031573)2.90012849
159left/right pattern formation (GO:0060972)2.89427945
160cellular protein complex localization (GO:0034629)2.88919759
161mitotic nuclear envelope disassembly (GO:0007077)2.88544395
162serine family amino acid biosynthetic process (GO:0009070)2.88440558
163CENP-A containing nucleosome assembly (GO:0034080)2.88196106
164exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87858542
165DNA catabolic process, exonucleolytic (GO:0000738)2.87770235
166kinetochore assembly (GO:0051382)2.87336645
167protein polyglutamylation (GO:0018095)2.86789559
168DNA strand elongation involved in DNA replication (GO:0006271)2.84934268
169* regulation of spindle checkpoint (GO:0090231)2.84592306
170DNA deamination (GO:0045006)2.83698645
171somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81164822
172somatic hypermutation of immunoglobulin genes (GO:0016446)2.81164822
173DNA conformation change (GO:0071103)2.80376286
174protein localization to cilium (GO:0061512)2.78723808
175DNA strand elongation (GO:0022616)2.76112724
176telomere maintenance via semi-conservative replication (GO:0032201)2.72874226
177gene silencing by RNA (GO:0031047)2.72765300
178chromosome organization (GO:0051276)2.71423659
179meiotic chromosome segregation (GO:0045132)2.69600211
180ATP-dependent chromatin remodeling (GO:0043044)2.69554177
181ether metabolic process (GO:0018904)2.69291641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.48101320
2E2F7_22180533_ChIP-Seq_HELA_Human6.47606152
3E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94538488
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78742469
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.75959484
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61506728
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57437873
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.52115182
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.31656671
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24277328
11* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.22944524
12ELK1_19687146_ChIP-ChIP_HELA_Human2.18582984
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15445220
14* NANOG_16153702_ChIP-ChIP_HESCs_Human2.10964837
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07361606
16* SOX2_16153702_ChIP-ChIP_HESCs_Human2.06330222
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.05074672
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90876440
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87874842
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84778107
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84014481
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82638137
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80822163
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78901845
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78818630
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77214827
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72188444
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71092399
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69476582
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65103286
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61373315
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59165909
33MYC_18940864_ChIP-ChIP_HL60_Human1.56946141
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.56203914
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53581089
36EWS_26573619_Chip-Seq_HEK293_Human1.53568869
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.53283131
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.49945621
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46200725
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45849988
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44345763
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42071788
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39847679
44EZH2_22144423_ChIP-Seq_EOC_Human1.38983946
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38840240
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36647065
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32648933
48SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29384419
49VDR_22108803_ChIP-Seq_LS180_Human1.28824050
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27862670
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24784050
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24704934
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23087933
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.22479846
55* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22434442
56DCP1A_22483619_ChIP-Seq_HELA_Human1.20989597
57* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20344201
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.19659001
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18776591
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.18396612
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17843880
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17811170
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14852687
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.14058872
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13780434
66FUS_26573619_Chip-Seq_HEK293_Human1.13757649
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13624797
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13138013
69AR_21909140_ChIP-Seq_LNCAP_Human1.12412277
70GATA3_21867929_ChIP-Seq_CD8_Mouse1.12353357
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11672973
72VDR_23849224_ChIP-Seq_CD4+_Human1.10418309
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.09925445
74ZNF274_21170338_ChIP-Seq_K562_Hela1.08487888
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.08373423
76XRN2_22483619_ChIP-Seq_HELA_Human1.07939192
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04853201
78* P300_19829295_ChIP-Seq_ESCs_Human1.03576725
79STAT1_17558387_ChIP-Seq_HELA_Human1.03568230
80TTF2_22483619_ChIP-Seq_HELA_Human1.03455078
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03079512
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01967660
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01819221
84SOX2_22085726_ChIP-Seq_NPCs_Mouse1.01509023
85KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01468100
86* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01125477
87ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00506057
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99019155
89* FOXP3_21729870_ChIP-Seq_TREG_Human0.97697265
90SRF_21415370_ChIP-Seq_HL-1_Mouse0.97566805
91* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95825015
92IRF1_19129219_ChIP-ChIP_H3396_Human0.95776706
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94833660
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94397090
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94162420
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94152776
97* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93585270
98FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93429153
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.93003388
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92523622
101WDR5_24793694_ChIP-Seq_LNCAP_Human0.92175587
102GABP_17652178_ChIP-ChIP_JURKAT_Human0.91734763
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91729917
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.91021099
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90258064
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90164860
107RNF2_27304074_Chip-Seq_NSC_Mouse0.90030815
108SOX9_26525672_Chip-Seq_HEART_Mouse0.89137144
109* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88899711
110* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88150053
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.87394630
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.87107092
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86708217
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86243100
115OCT4_18555785_Chip-Seq_ESCs_Mouse0.86157615
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84974939
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84490671
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84484669
119RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84426539
120* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84408483
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83519247
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83519247
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83519247
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81870149
125SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.81444941
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80957232
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.80849822
128TBX3_20139965_ChIP-Seq_MESCs_Mouse0.80612069
129SPI1_26923725_Chip-Seq_HPCs_Mouse0.80344177
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79293480
131SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79134543
132GABP_19822575_ChIP-Seq_HepG2_Human0.78963396
133* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77881398
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77751612
135* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77489126
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.77049435
137* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.77000226
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.76496916
139STAT3_18555785_ChIP-Seq_MESCs_Mouse0.76249085
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75872613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.10519833
2MP0003698_abnormal_male_reproductive4.47188029
3MP0001929_abnormal_gametogenesis4.26582972
4MP0002254_reproductive_system_inflammat3.76511291
5MP0010094_abnormal_chromosome_stability3.54107882
6MP0008057_abnormal_DNA_replication3.37605180
7MP0002210_abnormal_sex_determination3.13304001
8MP0008058_abnormal_DNA_repair3.05713493
9MP0003111_abnormal_nucleus_morphology2.81032191
10MP0001145_abnormal_male_reproductive2.67756348
11MP0001188_hyperpigmentation2.49898687
12MP0002161_abnormal_fertility/fecundity2.49025825
13MP0002653_abnormal_ependyma_morphology2.46474724
14MP0009672_abnormal_birth_weight2.44594733
15MP0003693_abnormal_embryo_hatching2.39293969
16MP0003077_abnormal_cell_cycle2.34345577
17MP0000653_abnormal_sex_gland2.33797853
18MP0004957_abnormal_blastocyst_morpholog2.20840961
19MP0003567_abnormal_fetal_cardiomyocyte2.15826619
20MP0003136_yellow_coat_color2.08785996
21MP0008007_abnormal_cellular_replicative2.02608728
22MP0005410_abnormal_fertilization10.5924051
23MP0010352_gastrointestinal_tract_polyps1.79303502
24MP0002160_abnormal_reproductive_system1.76732330
25MP0006292_abnormal_olfactory_placode1.75348902
26MP0004133_heterotaxia1.74504686
27MP0003786_premature_aging1.60637336
28MP0002102_abnormal_ear_morphology1.56156537
29MP0001293_anophthalmia1.55158325
30MP0005670_abnormal_white_adipose1.49005831
31MP0000579_abnormal_nail_morphology1.48632098
32MP0008932_abnormal_embryonic_tissue1.47053088
33MP0009703_decreased_birth_body1.42196792
34MP0002938_white_spotting1.38091682
35MP0003890_abnormal_embryonic-extraembry1.37024260
36MP0005377_hearing/vestibular/ear_phenot1.28530145
37MP0003878_abnormal_ear_physiology1.28530145
38MP0003122_maternal_imprinting1.25446236
39MP0001299_abnormal_eye_distance/1.20558742
40MP0001485_abnormal_pinna_reflex1.19607248
41MP0001730_embryonic_growth_arrest1.19538359
42MP0002233_abnormal_nose_morphology1.16647786
43MP0002111_abnormal_tail_morphology1.16223404
44MP0006035_abnormal_mitochondrial_morpho1.13310569
45MP0000350_abnormal_cell_proliferation1.11596310
46MP0005389_reproductive_system_phenotype1.11338575
47MP0000678_abnormal_parathyroid_gland1.10744103
48MP0002132_abnormal_respiratory_system1.08997490
49MP0004233_abnormal_muscle_weight1.05991976
50MP0001177_atelectasis1.05204926
51MP0003121_genomic_imprinting1.04087826
52MP0001672_abnormal_embryogenesis/_devel1.04002147
53MP0005380_embryogenesis_phenotype1.04002147
54MP0002085_abnormal_embryonic_tissue1.02450625
55MP0002796_impaired_skin_barrier1.02174843
56MP0009379_abnormal_foot_pigmentation1.01329252
57MP0002084_abnormal_developmental_patter1.00390466
58MP0000313_abnormal_cell_death0.99836284
59MP0003787_abnormal_imprinting0.98269195
60MP0000566_synostosis0.97671002
61MP0010307_abnormal_tumor_latency0.97287492
62MP0001697_abnormal_embryo_size0.95772174
63MP0004808_abnormal_hematopoietic_stem0.93614183
64MP0002751_abnormal_autonomic_nervous0.93225189
65MP0008995_early_reproductive_senescence0.92953638
66MP0000428_abnormal_craniofacial_morphol0.92014220
67MP0001986_abnormal_taste_sensitivity0.91078327
68MP0002736_abnormal_nociception_after0.90713269
69MP0001119_abnormal_female_reproductive0.88452636
70MP0003984_embryonic_growth_retardation0.86963579
71MP0005395_other_phenotype0.86657630
72MP0003123_paternal_imprinting0.86132189
73MP0002090_abnormal_vision0.86013205
74MP0005647_abnormal_sex_gland0.84929726
75MP0004197_abnormal_fetal_growth/weight/0.81963909
76MP0002088_abnormal_embryonic_growth/wei0.81095355
77MP0003315_abnormal_perineum_morphology0.80867100
78MP0000049_abnormal_middle_ear0.80418294
79MP0002080_prenatal_lethality0.80021829
80MP0002282_abnormal_trachea_morphology0.79549297
81MP0005623_abnormal_meninges_morphology0.78428550
82MP0003186_abnormal_redox_activity0.77429550
83MP0003941_abnormal_skin_development0.75577790
84MP0003646_muscle_fatigue0.74932931
85MP0003718_maternal_effect0.74683845
86MP0001545_abnormal_hematopoietic_system0.73747255
87MP0005397_hematopoietic_system_phenotyp0.73747255
88MP0000490_abnormal_crypts_of0.73621060
89MP0003119_abnormal_digestive_system0.72188642
90MP0003861_abnormal_nervous_system0.71575286
91MP0002019_abnormal_tumor_incidence0.71005273
92MP0000537_abnormal_urethra_morphology0.70611147
93MP0003755_abnormal_palate_morphology0.70339880
94MP0001529_abnormal_vocalization0.69030448
95MP0001984_abnormal_olfaction0.68260760
96MP0009697_abnormal_copulation0.67766215
97MP0005499_abnormal_olfactory_system0.67636355
98MP0005394_taste/olfaction_phenotype0.67636355
99MP0010030_abnormal_orbit_morphology0.66633236
100MP0008789_abnormal_olfactory_epithelium0.66507380
101MP0002086_abnormal_extraembryonic_tissu0.66020409
102MP0003699_abnormal_female_reproductive0.64939344
103MP0000631_abnormal_neuroendocrine_gland0.64728089
104MP0005391_vision/eye_phenotype0.64099689
105MP0003938_abnormal_ear_development0.63782826
106MP0001849_ear_inflammation0.63328511
107MP0003115_abnormal_respiratory_system0.63214651
108MP0003011_delayed_dark_adaptation0.61498702
109MP0003937_abnormal_limbs/digits/tail_de0.60592680
110MP0008770_decreased_survivor_rate0.60573800
111MP0000703_abnormal_thymus_morphology0.59854298
112MP0005075_abnormal_melanosome_morpholog0.59818386
113MP0005174_abnormal_tail_pigmentation0.59331294
114MP0002092_abnormal_eye_morphology0.59273339
115MP0000647_abnormal_sebaceous_gland0.56633256
116MP0002081_perinatal_lethality0.54178577
117MP0002249_abnormal_larynx_morphology0.53735384
118MP0000432_abnormal_head_morphology0.53563531
119MP0002234_abnormal_pharynx_morphology0.53388097
120MP0002396_abnormal_hematopoietic_system0.53091303
121MP0006036_abnormal_mitochondrial_physio0.52891171
122MP0001286_abnormal_eye_development0.51947367
123MP0000762_abnormal_tongue_morphology0.50969466
124MP0005253_abnormal_eye_physiology0.50341555
125MP0001324_abnormal_eye_pigmentation0.48300300
126MP0006072_abnormal_retinal_apoptosis0.48060260
127MP0000015_abnormal_ear_pigmentation0.46597061
128MP0000358_abnormal_cell_content/0.45541123
129MP0003950_abnormal_plasma_membrane0.44972534
130MP0003936_abnormal_reproductive_system0.44633926
131MP0002277_abnormal_respiratory_mucosa0.44381685
132MP0001919_abnormal_reproductive_system0.43325517
133MP0003283_abnormal_digestive_organ0.43262835
134MP0002697_abnormal_eye_size0.42793413

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)7.40866594
2Abnormal respiratory motile cilium morphology (HP:0005938)7.40866594
3Abnormal respiratory motile cilium physiology (HP:0012261)7.18850230
4Abnormal ciliary motility (HP:0012262)6.02976590
5Rhinitis (HP:0012384)5.98640150
6Chronic bronchitis (HP:0004469)5.59441881
7Colon cancer (HP:0003003)5.16027347
8Abnormality of the labia minora (HP:0012880)5.13728079
9Nasal polyposis (HP:0100582)4.42259413
10Infertility (HP:0000789)4.37449083
11Septo-optic dysplasia (HP:0100842)4.35883379
12Bronchitis (HP:0012387)3.82531441
13Bronchiectasis (HP:0002110)3.68814568
14Nephronophthisis (HP:0000090)3.63335689
15Abnormality of the nasal mucosa (HP:0000433)3.57783110
16Abnormal spermatogenesis (HP:0008669)3.32955975
17Impulsivity (HP:0100710)3.30317892
18Supernumerary spleens (HP:0009799)3.14052518
19Multiple enchondromatosis (HP:0005701)3.04942626
20Spastic diplegia (HP:0001264)2.96597469
21Abnormality of the renal medulla (HP:0100957)2.90914274
22Rhabdomyosarcoma (HP:0002859)2.83025361
23Recurrent sinusitis (HP:0011108)2.78238805
24Absent septum pellucidum (HP:0001331)2.75967058
25Abnormality of midbrain morphology (HP:0002418)2.71932919
26Molar tooth sign on MRI (HP:0002419)2.71932919
27Tubulointerstitial nephritis (HP:0001970)2.71459863
28Reticulocytopenia (HP:0001896)2.70968194
29Hypoglycemic seizures (HP:0002173)2.69713224
30Pancreatic islet-cell hyperplasia (HP:0004510)2.69349374
31Abnormality of the septum pellucidum (HP:0007375)2.68288214
32Hyperglycinemia (HP:0002154)2.67617691
33Recurrent bronchitis (HP:0002837)2.64591148
34Medial flaring of the eyebrow (HP:0010747)2.63857009
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62627846
36Maternal diabetes (HP:0009800)2.60620183
37Abnormality of serum amino acid levels (HP:0003112)2.59970215
38Abnormality of homocysteine metabolism (HP:0010919)2.59370990
39Homocystinuria (HP:0002156)2.59370990
40Chromsome breakage (HP:0040012)2.55179637
41Abnormal hair whorl (HP:0010721)2.53761675
42Male infertility (HP:0003251)2.51967001
43Bilateral microphthalmos (HP:0007633)2.50803352
44Stenosis of the external auditory canal (HP:0000402)2.50742267
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48427745
46Recurrent otitis media (HP:0000403)2.46349985
47Abnormality of methionine metabolism (HP:0010901)2.44038329
48Hepatoblastoma (HP:0002884)2.42222655
49Facial cleft (HP:0002006)2.41525543
50Choanal stenosis (HP:0000452)2.40983572
51Breast aplasia (HP:0100783)2.40417748
52Increased hepatocellular lipid droplets (HP:0006565)2.39840190
53Neoplasm of the colon (HP:0100273)2.38050660
54Cortical dysplasia (HP:0002539)2.33903585
55Abnormality of serine family amino acid metabolism (HP:0010894)2.33629738
56Abnormality of glycine metabolism (HP:0010895)2.33629738
57Biliary tract neoplasm (HP:0100574)2.27795499
58Aplasia/Hypoplasia of the breasts (HP:0010311)2.27510875
59Hyperglycinuria (HP:0003108)2.25591036
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.21388078
61Hyperinsulinemic hypoglycemia (HP:0000825)2.20607208
62Tubular atrophy (HP:0000092)2.18925915
63Gonadotropin excess (HP:0000837)2.18727255
64Esophageal atresia (HP:0002032)2.17282334
65Postaxial foot polydactyly (HP:0001830)2.16828419
66Abnormality of the preputium (HP:0100587)2.16229533
67Acute necrotizing encephalopathy (HP:0006965)2.15760750
68Acute encephalopathy (HP:0006846)2.14639469
69Type 2 muscle fiber atrophy (HP:0003554)2.14315219
70Methylmalonic acidemia (HP:0002912)2.13953060
71Abnormality of chromosome stability (HP:0003220)2.13821435
72Birth length less than 3rd percentile (HP:0003561)2.13147743
73Glioma (HP:0009733)2.12808004
74Aplasia/Hypoplasia of the sternum (HP:0006714)2.11947268
75Azoospermia (HP:0000027)2.11844333
76Carpal bone hypoplasia (HP:0001498)2.11241751
77Ectopic kidney (HP:0000086)2.10894785
78Meckel diverticulum (HP:0002245)2.10178969
79Cellular immunodeficiency (HP:0005374)2.08967744
80Megaloblastic anemia (HP:0001889)2.08835804
81Lipid accumulation in hepatocytes (HP:0006561)2.08368974
82Abnormality of the ileum (HP:0001549)2.07119636
83Optic nerve hypoplasia (HP:0000609)2.05305735
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04138909
85Sloping forehead (HP:0000340)2.02994086
86Chronic sinusitis (HP:0011109)2.02651847
87Bifid tongue (HP:0010297)2.02527073
88Abnormal number of incisors (HP:0011064)2.00995368
89Tubulointerstitial abnormality (HP:0001969)2.00965243
90Abnormality of abdominal situs (HP:0011620)2.00719305
91Abdominal situs inversus (HP:0003363)2.00719305
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1728099
93Dynein arm defect of respiratory motile cilia (HP:0012255)10.0446572
94Absent/shortened dynein arms (HP:0200106)10.0446572
95Aplasia involving forearm bones (HP:0009822)1.99954752
96Absent forearm bone (HP:0003953)1.99954752
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99564033
98Tongue fasciculations (HP:0001308)1.98430228
99Horseshoe kidney (HP:0000085)1.98373879
100Renal dysplasia (HP:0000110)1.98266677
101Increased nuchal translucency (HP:0010880)1.95934100
102Macrocytic anemia (HP:0001972)1.94546348
103Muscle fiber atrophy (HP:0100295)1.93496348
104Pancreatic fibrosis (HP:0100732)1.93465914
105Medulloblastoma (HP:0002885)1.93167178
106Symptomatic seizures (HP:0011145)1.92553808
107Neoplasm of the adrenal gland (HP:0100631)1.92002394
108Duodenal stenosis (HP:0100867)1.91484052
109Small intestinal stenosis (HP:0012848)1.91484052
110Embryonal neoplasm (HP:0002898)1.91104730
111Neoplasm of the adrenal cortex (HP:0100641)1.91022848
112Pendular nystagmus (HP:0012043)1.90841522
113Congenital primary aphakia (HP:0007707)1.88912629
114Nephroblastoma (Wilms tumor) (HP:0002667)1.88013614
115Abnormality of the renal collecting system (HP:0004742)1.88010178
116Abnormal lung lobation (HP:0002101)1.87701266
117Gastrointestinal atresia (HP:0002589)1.86745408
118Decreased central vision (HP:0007663)1.86324244
119Congenital hepatic fibrosis (HP:0002612)1.85901322
120Hypoplastic female external genitalia (HP:0012815)1.85822086
121Abnormality of the clitoris (HP:0000056)1.84400547
122Volvulus (HP:0002580)1.84080493
123Absent thumb (HP:0009777)1.83685324
124Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83219836
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.83034516
126Tracheoesophageal fistula (HP:0002575)1.80504776
127Short ribs (HP:0000773)1.78725366
128Neoplasm of striated muscle (HP:0009728)1.78704224
129Aqueductal stenosis (HP:0002410)1.78677430
130Uterine neoplasm (HP:0010784)1.78382318
131Malignant gastrointestinal tract tumors (HP:0006749)1.78091218
132Gastrointestinal carcinoma (HP:0002672)1.78091218
133Cleft eyelid (HP:0000625)1.77809831
134Astrocytoma (HP:0009592)1.77166055
135Abnormality of the astrocytes (HP:0100707)1.77166055
136Sensory axonal neuropathy (HP:0003390)1.74852947
137Median cleft lip (HP:0000161)1.74049766
138Breast carcinoma (HP:0003002)1.73831283
139Selective tooth agenesis (HP:0001592)1.70555114
140Embryonal renal neoplasm (HP:0011794)1.69735336
141Severe visual impairment (HP:0001141)1.68043819
142Heterotopia (HP:0002282)1.67601922
143Agnosia (HP:0010524)1.66855102
144Abnormality of the renal cortex (HP:0011035)1.65121427
145Nephrogenic diabetes insipidus (HP:0009806)1.64118085
146Gait imbalance (HP:0002141)1.62975193
147Muscle fibrillation (HP:0010546)1.62931966
148Myelodysplasia (HP:0002863)1.62132387
149Postaxial hand polydactyly (HP:0001162)1.60360817
150Neoplasm of the oral cavity (HP:0100649)1.58991914
151Abnormality of the duodenum (HP:0002246)1.58175435
152Abnormality of the lower motor neuron (HP:0002366)1.57185297
153Pancreatic cysts (HP:0001737)1.57015425
154Fibular hypoplasia (HP:0003038)1.55997946
155Duplicated collecting system (HP:0000081)1.55789055
156Abnormality of the carotid arteries (HP:0005344)1.54773034
157Absent radius (HP:0003974)1.53760316
158Dyschromatopsia (HP:0007641)1.52658139
15911 pairs of ribs (HP:0000878)1.51752381
160Ependymoma (HP:0002888)1.51098000
161Chronic hepatic failure (HP:0100626)1.51057022
162Intestinal atresia (HP:0011100)1.50658948
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50382883
164Absent epiphyses (HP:0010577)1.50382883
165Preaxial hand polydactyly (HP:0001177)1.50062436
166Triphalangeal thumb (HP:0001199)1.49259054
167Abnormal biliary tract physiology (HP:0012439)1.48260456
168Bile duct proliferation (HP:0001408)1.48260456
169Oculomotor apraxia (HP:0000657)1.46989970
170Aplasia/hypoplasia of the humerus (HP:0006507)1.46811128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.99215144
2PDK45.99215144
3TESK14.35014634
4PDK23.78345279
5TNIK3.21697665
6ICK3.04179057
7CDC72.93660935
8VRK22.90603753
9NEK22.89702778
10TAF12.64535788
11WEE12.60652586
12BUB12.54520524
13PRKD32.51444483
14PLK42.32162526
15CDK122.29291926
16WNK32.11623851
17MST42.10340541
18SRPK11.91374529
19PASK1.89794793
20TTK1.86957962
21PNCK1.84550430
22NUAK11.82642591
23NEK11.75542240
24TRIM281.72441785
25CHEK21.70122122
26ATR1.62850595
27CDK191.62340250
28DYRK21.46563635
29MKNK11.45115558
30PLK11.35263251
31NME11.31642332
32DYRK31.28605311
33ALK1.26738450
34EPHA21.26208487
35CHEK11.26128564
36TSSK61.25352669
37ZAK1.24839151
38EIF2AK11.24697884
39VRK11.24648790
40MKNK21.22378625
41PTK2B1.21358432
42STK161.19497633
43CDK71.18445884
44NLK1.17900400
45PBK1.16799557
46BMPR1B1.13677708
47CCNB11.10229949
48YES11.01051883
49BRSK21.00814966
50ATM0.97856862
51PLK30.93234493
52AURKB0.92104472
53STK38L0.90154473
54FGFR10.89421331
55TLK10.87759808
56CSNK1G10.87288517
57STK390.84456625
58STK380.83859890
59STK240.83546595
60PAK40.81266959
61TESK20.80080120
62OXSR10.79967350
63ACVR1B0.78624045
64FGFR20.78126539
65RPS6KB20.75954584
66EEF2K0.74414828
67CDK40.74015510
68PLK20.73065205
69AURKA0.72424030
70TIE10.71044440
71WNK40.70989449
72STK40.69523666
73ERBB40.67456711
74AKT30.65486700
75CDK20.63782883
76LATS10.62985204
77STK30.61858421
78NEK60.59549763
79DYRK1B0.59353889
80RPS6KA40.58334540
81SIK30.58230738
82BRD40.57396745
83MAP3K90.57056662
84PIM10.55964724
85CSNK2A20.55285006
86CAMK1G0.52083117
87RPS6KB10.52061401
88LATS20.51420240
89PDK10.51308829
90MAP2K60.51117373
91CSNK1G20.50640153
92CDK10.50279369
93SMG10.50017508
94PAK10.49944482
95CSNK2A10.48827959
96BRSK10.48635438
97CASK0.47275650
98CDK30.45622891
99EIF2AK30.44076461
100GRK10.42435412
101CSNK1G30.40070506
102MUSK0.39139126
103CDK60.38216862
104CSNK1D0.38136544
105PRKCG0.37669251
106DMPK0.37059317
107STK100.36351024
108CAMK1D0.35835811
109FLT30.35221366
110CLK10.32718289
111DYRK1A0.32180327
112ADRBK20.32100383
113TYRO30.31994609
114MTOR0.31566156
115INSRR0.31520768
116BTK0.30435399
117EIF2AK20.29572082
118IRAK10.29452663
119TXK0.28929955
120PRKDC0.28330562
121DAPK10.28115244
122BCR0.27994437
123BMX0.27867890
124MAP3K80.27261612
125GSK3B0.27016428
126BRAF0.26966548
127NME20.25981972
128TGFBR10.25781109
129CSNK1A10.25697097
130RPS6KA10.24056002
131EGFR0.23709702
132MAP3K40.23001287
133BLK0.22786022
134RPS6KA50.21910382
135CSNK1E0.21476710
136MAPK150.20705794
137PINK10.20635699
138MAP4K20.20622664
139MAPK140.20232729
140CSNK1A1L0.19925577
141MAPK10.14551507
142MAP3K100.13306502
143CSF1R0.11811675

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.43964952
2Mismatch repair_Homo sapiens_hsa034303.92439754
3Fanconi anemia pathway_Homo sapiens_hsa034603.51578734
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50873375
5Basal transcription factors_Homo sapiens_hsa030223.33304622
6Homologous recombination_Homo sapiens_hsa034403.14134373
7RNA transport_Homo sapiens_hsa030133.10706252
8Spliceosome_Homo sapiens_hsa030403.03504324
9Base excision repair_Homo sapiens_hsa034102.61115438
10Non-homologous end-joining_Homo sapiens_hsa034502.46666324
11Cell cycle_Homo sapiens_hsa041102.42142396
12Nucleotide excision repair_Homo sapiens_hsa034202.42119491
13Proteasome_Homo sapiens_hsa030502.37248844
14Pyrimidine metabolism_Homo sapiens_hsa002402.30831768
15mRNA surveillance pathway_Homo sapiens_hsa030152.28248270
16Vitamin B6 metabolism_Homo sapiens_hsa007502.26682430
17RNA polymerase_Homo sapiens_hsa030202.19187905
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.10485672
19RNA degradation_Homo sapiens_hsa030181.88147114
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87232141
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83848034
22Purine metabolism_Homo sapiens_hsa002301.83658378
23Protein export_Homo sapiens_hsa030601.83278599
24One carbon pool by folate_Homo sapiens_hsa006701.79574195
25Systemic lupus erythematosus_Homo sapiens_hsa053221.66450020
26Fatty acid biosynthesis_Homo sapiens_hsa000611.62724973
27Parkinsons disease_Homo sapiens_hsa050121.57029165
28Oxidative phosphorylation_Homo sapiens_hsa001901.56726161
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48092226
30Ribosome_Homo sapiens_hsa030101.44936439
31Oocyte meiosis_Homo sapiens_hsa041141.44198051
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43415415
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43210170
34Linoleic acid metabolism_Homo sapiens_hsa005911.42396960
35Selenocompound metabolism_Homo sapiens_hsa004501.37713640
36Pentose phosphate pathway_Homo sapiens_hsa000301.34169392
37Steroid biosynthesis_Homo sapiens_hsa001001.30546679
38Pyruvate metabolism_Homo sapiens_hsa006201.27131596
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23798768
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.23789650
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23269747
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22743525
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21405096
44p53 signaling pathway_Homo sapiens_hsa041151.19015698
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13534588
46Vitamin digestion and absorption_Homo sapiens_hsa049771.10719898
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09448275
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08838504
49Antigen processing and presentation_Homo sapiens_hsa046120.95420630
50Epstein-Barr virus infection_Homo sapiens_hsa051690.94777443
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93833980
52Fructose and mannose metabolism_Homo sapiens_hsa000510.92059913
53Viral carcinogenesis_Homo sapiens_hsa052030.90449108
54Alzheimers disease_Homo sapiens_hsa050100.85747686
55Fatty acid elongation_Homo sapiens_hsa000620.84820570
56Glucagon signaling pathway_Homo sapiens_hsa049220.83032514
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81981969
58Huntingtons disease_Homo sapiens_hsa050160.81798573
59Herpes simplex infection_Homo sapiens_hsa051680.81578566
60Basal cell carcinoma_Homo sapiens_hsa052170.79966309
61Biosynthesis of amino acids_Homo sapiens_hsa012300.77967433
62Hedgehog signaling pathway_Homo sapiens_hsa043400.77268615
63Alcoholism_Homo sapiens_hsa050340.74417827
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73683501
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72267032
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71096910
67Tight junction_Homo sapiens_hsa045300.69512147
68Adherens junction_Homo sapiens_hsa045200.69486018
69Folate biosynthesis_Homo sapiens_hsa007900.68719593
70Legionellosis_Homo sapiens_hsa051340.62706783
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61807317
72HTLV-I infection_Homo sapiens_hsa051660.60309602
73Thyroid cancer_Homo sapiens_hsa052160.60036938
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58663283
75Arachidonic acid metabolism_Homo sapiens_hsa005900.58083956
76Lysine degradation_Homo sapiens_hsa003100.56125722
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55497715
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52655219
79Renin-angiotensin system_Homo sapiens_hsa046140.51106491
80Arginine and proline metabolism_Homo sapiens_hsa003300.49548371
81Wnt signaling pathway_Homo sapiens_hsa043100.48352619
82Fatty acid degradation_Homo sapiens_hsa000710.47938897
83Primary immunodeficiency_Homo sapiens_hsa053400.47511793
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45340294
85Ether lipid metabolism_Homo sapiens_hsa005650.44911372
86TGF-beta signaling pathway_Homo sapiens_hsa043500.44401493
87beta-Alanine metabolism_Homo sapiens_hsa004100.44229241
88Glycerolipid metabolism_Homo sapiens_hsa005610.43826360
89Carbon metabolism_Homo sapiens_hsa012000.43414046
90Propanoate metabolism_Homo sapiens_hsa006400.42847955
91Retinol metabolism_Homo sapiens_hsa008300.42028613
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.41519009
93Measles_Homo sapiens_hsa051620.41311664
94Phototransduction_Homo sapiens_hsa047440.40188232
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38608089
96Glutathione metabolism_Homo sapiens_hsa004800.38302465
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37802807
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.37692447
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.37296261
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36439199
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36393953
102Caffeine metabolism_Homo sapiens_hsa002320.32931801
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31957200
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31675274
105Fatty acid metabolism_Homo sapiens_hsa012120.29592152
106Tryptophan metabolism_Homo sapiens_hsa003800.29551407
107Notch signaling pathway_Homo sapiens_hsa043300.28545014
108Metabolic pathways_Homo sapiens_hsa011000.28150196
109Hippo signaling pathway_Homo sapiens_hsa043900.27224253
110Galactose metabolism_Homo sapiens_hsa000520.26920894
111Nicotine addiction_Homo sapiens_hsa050330.25795080
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25684089
113Mineral absorption_Homo sapiens_hsa049780.25192446
114Colorectal cancer_Homo sapiens_hsa052100.22258426
115N-Glycan biosynthesis_Homo sapiens_hsa005100.21641473
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21347143
117Graft-versus-host disease_Homo sapiens_hsa053320.21182207
118Fat digestion and absorption_Homo sapiens_hsa049750.21039996
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.20583285
120Autoimmune thyroid disease_Homo sapiens_hsa053200.20082784
121Butanoate metabolism_Homo sapiens_hsa006500.18922604
122Arginine biosynthesis_Homo sapiens_hsa002200.18872005
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17705805
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17420024
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17295009
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17264093
127HIF-1 signaling pathway_Homo sapiens_hsa040660.15112438
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15063039
129Amphetamine addiction_Homo sapiens_hsa050310.14833188
130Taste transduction_Homo sapiens_hsa047420.14394359
131MicroRNAs in cancer_Homo sapiens_hsa052060.14132184
132Peroxisome_Homo sapiens_hsa041460.14016930
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13634038
134Influenza A_Homo sapiens_hsa051640.13208323
135Starch and sucrose metabolism_Homo sapiens_hsa005000.11609469
136Calcium signaling pathway_Homo sapiens_hsa040200.10374366
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10270284
138Cardiac muscle contraction_Homo sapiens_hsa042600.09504200
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09318892
140Inositol phosphate metabolism_Homo sapiens_hsa005620.08920806
141Type I diabetes mellitus_Homo sapiens_hsa049400.08667727
142Allograft rejection_Homo sapiens_hsa053300.06360073
143Intestinal immune network for IgA production_Homo sapiens_hsa046720.06057571
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.05821014
145Hematopoietic cell lineage_Homo sapiens_hsa046400.05613642
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.05292753
147Dorso-ventral axis formation_Homo sapiens_hsa043200.05021674
148Pathways in cancer_Homo sapiens_hsa052000.04520681

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