USP35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86382119
2synaptic vesicle maturation (GO:0016188)3.85602182
3cell-cell junction maintenance (GO:0045217)3.85508859
4proline transport (GO:0015824)3.83231083
5mannose metabolic process (GO:0006013)3.74755405
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.67179244
7regulation of synaptic vesicle exocytosis (GO:2000300)3.63431845
8synaptic vesicle exocytosis (GO:0016079)3.49851117
9locomotory exploration behavior (GO:0035641)3.42757913
10neuronal action potential propagation (GO:0019227)3.31629585
11synaptic vesicle endocytosis (GO:0048488)3.28343525
12semaphorin-plexin signaling pathway (GO:0071526)3.28204484
13insulin secretion (GO:0030073)3.25029501
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24587068
15negative regulation of erythrocyte differentiation (GO:0045647)3.23102179
16cytoskeletal anchoring at plasma membrane (GO:0007016)3.22178372
17adherens junction assembly (GO:0034333)3.20760656
18regulation of synaptic vesicle transport (GO:1902803)3.20365608
19neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.16678393
20basement membrane organization (GO:0071711)3.13914262
21activation of protein kinase A activity (GO:0034199)3.10516693
22regulation of ARF GTPase activity (GO:0032312)3.09086262
23cerebellar Purkinje cell differentiation (GO:0021702)3.08335723
24protein localization to endosome (GO:0036010)3.06967440
25cell-substrate adherens junction assembly (GO:0007045)3.04245969
26focal adhesion assembly (GO:0048041)3.04245969
27negative regulation of fatty acid transport (GO:2000192)3.01941261
28regulation of early endosome to late endosome transport (GO:2000641)2.99168034
29membrane depolarization during action potential (GO:0086010)2.98627232
30insulin-like growth factor receptor signaling pathway (GO:0048009)2.98566824
31vesicle transport along microtubule (GO:0047496)2.95113118
32glutamate secretion (GO:0014047)2.91947209
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90560299
34cell junction maintenance (GO:0034331)2.89876434
35detection of calcium ion (GO:0005513)2.87343249
36cell-substrate junction assembly (GO:0007044)2.84282059
37protein targeting to Golgi (GO:0000042)2.84221665
38chemosensory behavior (GO:0007635)2.83798743
39negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83412172
40response to laminar fluid shear stress (GO:0034616)2.82418999
41adenosine receptor signaling pathway (GO:0001973)2.82370870
42presynaptic membrane assembly (GO:0097105)2.81504462
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80477082
44response to muramyl dipeptide (GO:0032495)2.79911138
45atrioventricular valve morphogenesis (GO:0003181)2.79112584
46regulation of NFAT protein import into nucleus (GO:0051532)2.75842842
47neurotransmitter secretion (GO:0007269)2.74806915
48negative regulation of bone resorption (GO:0045779)2.74735372
49endothelial cell chemotaxis (GO:0035767)2.74477296
50positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.74062051
51dendrite morphogenesis (GO:0048813)2.73547276
52regulation of vesicle fusion (GO:0031338)2.72983513
53suckling behavior (GO:0001967)2.72960094
54epithelial cell-cell adhesion (GO:0090136)2.71179242
55regulation of glutamate receptor signaling pathway (GO:1900449)2.70073628
56regulation of ARF protein signal transduction (GO:0032012)2.69302000
57establishment of protein localization to Golgi (GO:0072600)2.67039530
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66850412
59neuromuscular process controlling posture (GO:0050884)2.65494295
60histone H3-K9 demethylation (GO:0033169)2.65397663
61membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.65068200
62SMAD protein complex assembly (GO:0007183)2.64629639
63innervation (GO:0060384)2.64598475
64regulation of beta-amyloid formation (GO:1902003)2.64528649
65postsynaptic membrane organization (GO:0001941)2.63974311
66glycine transport (GO:0015816)2.63405051
67positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61022566
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.60704077
69regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.58778968
70cell migration in hindbrain (GO:0021535)2.58283634
71stress fiber assembly (GO:0043149)2.57663795
72detection of temperature stimulus involved in sensory perception (GO:0050961)2.57580633
73detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.57580633
74regulation of amyloid precursor protein catabolic process (GO:1902991)2.57019050
75negative regulation of cell size (GO:0045792)2.56679192
76vocalization behavior (GO:0071625)2.52467881
77activation of Rac GTPase activity (GO:0032863)2.51539518
78retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51231761
79nerve growth factor signaling pathway (GO:0038180)2.49580071
80exploration behavior (GO:0035640)2.49509562
81positive regulation of synaptic transmission, GABAergic (GO:0032230)2.48589697
82presynaptic membrane organization (GO:0097090)2.48431558
83relaxation of cardiac muscle (GO:0055119)2.48336345
84positive regulation of exocytosis (GO:0045921)2.47714790
85organelle transport along microtubule (GO:0072384)2.47593668
86neuron cell-cell adhesion (GO:0007158)2.47291518
87barbed-end actin filament capping (GO:0051016)2.46761448
88regulation of histone H3-K27 methylation (GO:0061085)2.44353985
89neuromuscular process controlling balance (GO:0050885)2.43671862
90detection of temperature stimulus (GO:0016048)2.43604469
91regulation of calcium ion-dependent exocytosis (GO:0017158)2.42814388
92neurofilament cytoskeleton organization (GO:0060052)2.41847941
93regulation of cAMP-dependent protein kinase activity (GO:2000479)2.41042781
94regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.40123235
95positive regulation of protein dephosphorylation (GO:0035307)2.39860664
96peptide hormone secretion (GO:0030072)2.39173227
97regulation of exocytosis (GO:0017157)2.38629144
98transmission of nerve impulse (GO:0019226)2.38002727
99neuronal ion channel clustering (GO:0045161)2.37928768
100regulation of neurotransmitter secretion (GO:0046928)2.37154735
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.37074451
102peptide secretion (GO:0002790)2.36805162
103regulation of extracellular matrix disassembly (GO:0010715)2.36642469
104protein localization to synapse (GO:0035418)2.36219840
105activation of JUN kinase activity (GO:0007257)2.35665744
106response to auditory stimulus (GO:0010996)2.35610670
107neuron recognition (GO:0008038)2.35601079
108positive regulation of receptor recycling (GO:0001921)2.35322271
109membrane depolarization (GO:0051899)2.34889136
110skin morphogenesis (GO:0043589)2.34084570
111membrane repolarization during action potential (GO:0086011)2.33620049
112regulation of cholesterol biosynthetic process (GO:0045540)2.33092566
113interleukin-1-mediated signaling pathway (GO:0070498)2.32735525
114cellular potassium ion homeostasis (GO:0030007)2.32553385
115regulation of insulin secretion (GO:0050796)2.31903741
116synaptic vesicle transport (GO:0048489)2.31176359
117establishment of synaptic vesicle localization (GO:0097480)2.31176359
118regulation of glucose import in response to insulin stimulus (GO:2001273)2.30670511
119synaptic vesicle docking involved in exocytosis (GO:0016081)2.30522046
120neurotransmitter transport (GO:0006836)2.30342178
121protein targeting to plasma membrane (GO:0072661)2.29532675
122regulation of Golgi to plasma membrane protein transport (GO:0042996)2.29422071
123detection of molecule of bacterial origin (GO:0032490)2.29367549
124regulation of protein polyubiquitination (GO:1902914)2.29000732
125axonal fasciculation (GO:0007413)2.28591473
126signal release (GO:0023061)2.27824464
127cerebellar Purkinje cell layer development (GO:0021680)2.27747617
128vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27110300
129macroautophagy (GO:0016236)2.26830368
130apoptotic process involved in morphogenesis (GO:0060561)2.26767732
131regulation of neuronal synaptic plasticity (GO:0048168)2.26137246
132synapse assembly (GO:0007416)2.25962120
133cellular response to ATP (GO:0071318)2.24384047
134modulation by symbiont of host cellular process (GO:0044068)2.24136579
135establishment of vesicle localization (GO:0051650)2.24075878
136protein kinase C signaling (GO:0070528)2.23965639
137ionotropic glutamate receptor signaling pathway (GO:0035235)2.23124098
138mating behavior (GO:0007617)2.22781103
139endocrine pancreas development (GO:0031018)2.22765704
140cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.22630680
141venous blood vessel morphogenesis (GO:0048845)2.22516490
142positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21926617
143ear development (GO:0043583)2.21300611
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.21232119
145COPI coating of Golgi vesicle (GO:0048205)2.21009274
146Golgi transport vesicle coating (GO:0048200)2.21009274
147cellular response to glucagon stimulus (GO:0071377)2.20668096
148histone lysine demethylation (GO:0070076)2.20333605
149neuronal action potential (GO:0019228)2.19915690
150gamma-aminobutyric acid transport (GO:0015812)2.19231952
151long-term memory (GO:0007616)2.19076155
152regulation of excitatory postsynaptic membrane potential (GO:0060079)2.17894492
153ER overload response (GO:0006983)2.17408645
154negative regulation of fibrinolysis (GO:0051918)2.17184738
155histone H4 deacetylation (GO:0070933)2.16232699
156positive regulation of cellular response to insulin stimulus (GO:1900078)2.15954451
157planar cell polarity pathway involved in neural tube closure (GO:0090179)2.15474916
158regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.13331956
159hemidesmosome assembly (GO:0031581)2.12883622
160chondroitin sulfate biosynthetic process (GO:0030206)2.12356251
161positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.11280014
162histone demethylation (GO:0016577)2.10397992
163protein heterotrimerization (GO:0070208)2.09965553
164protein retention in ER lumen (GO:0006621)2.07392140
165peptidyl-glutamic acid carboxylation (GO:0017187)2.07305443
166protein carboxylation (GO:0018214)2.07305443
167regulation of fatty acid beta-oxidation (GO:0031998)2.06821574
168activation of MAPKKK activity (GO:0000185)2.06694847
169regulation of mammary gland epithelial cell proliferation (GO:0033599)2.06423288
170endodermal cell differentiation (GO:0035987)2.05809737
171cortical actin cytoskeleton organization (GO:0030866)2.05217485
172positive regulation of extracellular matrix organization (GO:1903055)2.04966943
173actin filament bundle assembly (GO:0051017)2.04847219
174actin filament bundle organization (GO:0061572)2.04847219
175embryonic eye morphogenesis (GO:0048048)2.03823897
176substrate-dependent cell migration (GO:0006929)2.03758115
177cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.02980092
178cortical cytoskeleton organization (GO:0030865)2.02762888
179histone H3-K36 demethylation (GO:0070544)2.02674076
180response to fluid shear stress (GO:0034405)2.01497629
181regulation of cholesterol homeostasis (GO:2000188)2.01335197
182negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.01123856
183regulation of T-helper 2 cell differentiation (GO:0045628)2.01074675
184negative regulation of granulocyte differentiation (GO:0030853)2.01055054
185cell adhesion mediated by integrin (GO:0033627)2.00688215
186low-density lipoprotein particle clearance (GO:0034383)2.00193393
187regulation of nucleobase-containing compound transport (GO:0032239)2.00186990
188intracellular estrogen receptor signaling pathway (GO:0030520)2.00072127
189blood vessel endothelial cell migration (GO:0043534)2.00024602
190positive regulation of histone deacetylation (GO:0031065)1.99726983
191endocytic recycling (GO:0032456)1.98036377
192regulation of cell migration involved in sprouting angiogenesis (GO:0090049)1.98029271
193dopamine receptor signaling pathway (GO:0007212)1.97960238
194positive regulation of Cdc42 GTPase activity (GO:0043089)1.97882960
195extracellular matrix assembly (GO:0085029)1.96671588
196activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.95796132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.71167528
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.35452868
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.31206665
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.88903401
5GBX2_23144817_ChIP-Seq_PC3_Human2.83166129
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77951226
7* LXR_22292898_ChIP-Seq_THP-1_Human2.70668202
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56539363
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.44954718
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.44107682
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40474808
12VDR_21846776_ChIP-Seq_THP-1_Human2.39411027
13KDM2B_26808549_Chip-Seq_DND41_Human2.36937459
14DROSHA_22980978_ChIP-Seq_HELA_Human2.36592992
15TCF7_22412390_ChIP-Seq_EML_Mouse2.25614547
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25610061
17REST_21632747_ChIP-Seq_MESCs_Mouse2.23823259
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23379258
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18516781
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10236059
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04660135
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99524966
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99096007
24RACK7_27058665_Chip-Seq_MCF-7_Human1.96587332
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95225736
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95225736
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.94131392
28MYC_22102868_ChIP-Seq_BL_Human1.91192421
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90632369
30KDM2B_26808549_Chip-Seq_JURKAT_Human1.86739051
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86318779
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86314470
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.83931266
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.80369944
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.80046664
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79712405
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76778688
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76237827
39* EZH2_27294783_Chip-Seq_ESCs_Mouse1.71935321
40GATA1_22025678_ChIP-Seq_K562_Human1.68097646
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.65785171
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64354009
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64206770
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60652734
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57868899
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57584293
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55958429
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.54921645
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53964856
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53722327
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52822065
52SMC4_20622854_ChIP-Seq_HELA_Human1.52128496
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.48605330
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48567388
55IGF1R_20145208_ChIP-Seq_DFB_Human1.46937063
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46864155
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44293320
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43831971
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42955702
60VDR_24763502_ChIP-Seq_THP-1_Human1.42757546
61P68_20966046_ChIP-Seq_HELA_Human1.41915518
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40813347
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38037221
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37724599
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36432236
66SMAD4_21799915_ChIP-Seq_A2780_Human1.35436240
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34835067
68CREB1_26743006_Chip-Seq_LNCaP_Human1.34668466
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.34322560
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32704495
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.29216024
72STAT3_23295773_ChIP-Seq_U87_Human1.28984248
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.27229910
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27197264
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25904337
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25442625
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25410816
78KDM2B_26808549_Chip-Seq_K562_Human1.24831440
79CLOCK_20551151_ChIP-Seq_293T_Human1.24655307
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23995748
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.23883107
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23607642
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23294938
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22348504
85ZNF263_19887448_ChIP-Seq_K562_Human1.20731794
86TP53_22127205_ChIP-Seq_IMR90_Human1.20638518
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.20359336
88MAF_26560356_Chip-Seq_TH1_Human1.19696055
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19538501
90AHR_22903824_ChIP-Seq_MCF-7_Human1.19468522
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.18974169
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18851509
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18577301
94* CTCF_27219007_Chip-Seq_Bcells_Human1.18200593
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17899464
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17768031
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.17414500
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17321827
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17231028
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14834041
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14328155
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14073145
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13855420
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13788148
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.13443203
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13053700
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12436755
108MAF_26560356_Chip-Seq_TH2_Human1.12141523
109AR_19668381_ChIP-Seq_PC3_Human1.10934614
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.10070638
111BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09811367
112TCF4_23295773_ChIP-Seq_U87_Human1.09688291
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09670852
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.08725305
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08448129
116SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08045985
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.07621226
118TET1_21490601_ChIP-Seq_MESCs_Mouse1.06924810
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06909812
120SMAD3_21741376_ChIP-Seq_ESCs_Human1.06870652
121UTX_26944678_Chip-Seq_JUKART_Human1.06591252
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05691865
123P300_19829295_ChIP-Seq_ESCs_Human1.05340236
124TBX20_22080862_ChIP-Seq_HEART_Mouse1.05232918
125TBX20_22328084_ChIP-Seq_HEART_Mouse1.05232918
126SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04546573
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04164294
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04062114
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03789736
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02284379
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02122411
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01975508
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.01872430
134TP63_22573176_ChIP-Seq_HFKS_Human1.01228524
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00689821
136RXR_22158963_ChIP-Seq_LIVER_Mouse1.00401042
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00358378
138NCOR1_26117541_ChIP-Seq_K562_Human1.00336457
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.99842847
140SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99434796
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99120844
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98991106
143TP53_23651856_ChIP-Seq_MEFs_Mouse0.97838447
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97741623
145ATF3_27146783_Chip-Seq_COLON_Human0.97727253
146AR_25329375_ChIP-Seq_VCAP_Human0.97259943
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.96701071
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96405359
149SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95878624
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95850987
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95798832
152RUNX1_22412390_ChIP-Seq_EML_Mouse0.95489520
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95432374
154OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95013387
155RUNX2_22187159_ChIP-Seq_PCA_Human0.94886325
156ESR2_21235772_ChIP-Seq_MCF-7_Human0.94825224
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94430253
158SPI1_23127762_ChIP-Seq_K562_Human0.93870920
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.93424775
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93380306
161TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92865723
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92338420
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92131301
164TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90858872
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90858872
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90569439
167RING1B_27294783_Chip-Seq_NPCs_Mouse0.90250475
168TAF15_26573619_Chip-Seq_HEK293_Human0.89225834
169GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89063072
170VDR_22108803_ChIP-Seq_LS180_Human0.88712852
171SMAD3_21741376_ChIP-Seq_HESCs_Human0.87990346
172ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87902550
173SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86447729
174TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86079400
175EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85895892
176TP53_16413492_ChIP-PET_HCT116_Human0.85678032
177CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84538985
178* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83838525
179CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83519463
180WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83119678
181MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82457983
182RING1B_27294783_Chip-Seq_ESCs_Mouse0.82141705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.89225583
2MP0004859_abnormal_synaptic_plasticity3.84846192
3MP0008438_abnormal_cutaneous_collagen3.44252524
4MP0005409_darkened_coat_color3.36877015
5MP0009840_abnormal_foam_cell3.09337931
6MP0010386_abnormal_urinary_bladder2.98283239
7MP0004270_analgesia2.91627243
8MP0005645_abnormal_hypothalamus_physiol2.89751373
9MP0001986_abnormal_taste_sensitivity2.82977632
10MP0002735_abnormal_chemical_nociception2.80209780
11MP0005076_abnormal_cell_differentiation2.74216941
12MP0003172_abnormal_lysosome_physiology2.69359608
13MP0005451_abnormal_body_composition2.65937181
14MP0003183_abnormal_peptide_metabolism2.63877688
15MP0003635_abnormal_synaptic_transmissio2.59866391
16MP0002909_abnormal_adrenal_gland2.50903609
17MP0002734_abnormal_mechanical_nocicepti2.45665949
18MP0009780_abnormal_chondrocyte_physiolo2.45545311
19MP0003279_aneurysm2.43434711
20MP0005423_abnormal_somatic_nervous2.42888209
21MP0003283_abnormal_digestive_organ2.40455980
22MP0002733_abnormal_thermal_nociception2.38208386
23MP0003436_decreased_susceptibility_to2.36130975
24MP0001968_abnormal_touch/_nociception2.33490990
25MP0003091_abnormal_cell_migration2.30238050
26MP0008260_abnormal_autophagy2.30164981
27MP0001849_ear_inflammation2.29892364
28MP0003880_abnormal_central_pattern2.29740822
29MP0002877_abnormal_melanocyte_morpholog2.28517585
30MP0004858_abnormal_nervous_system2.28058322
31MP0001501_abnormal_sleep_pattern2.23574303
32MP0003566_abnormal_cell_adhesion2.21137579
33MP0005310_abnormal_salivary_gland2.20545897
34MP0009046_muscle_twitch2.19234306
35MP0002254_reproductive_system_inflammat2.17590350
36MP0002693_abnormal_pancreas_physiology2.15609906
37MP0002064_seizures2.14419158
38MP0001958_emphysema2.12191827
39MP0001970_abnormal_pain_threshold2.10298811
40MP0000569_abnormal_digit_pigmentation2.04530273
41MP0001348_abnormal_lacrimal_gland2.02421245
42MP0002736_abnormal_nociception_after1.98914025
43MP0009745_abnormal_behavioral_response1.98285459
44MP0002272_abnormal_nervous_system1.96419869
45MP0004510_myositis1.93360810
46MP0002063_abnormal_learning/memory/cond1.91072108
47MP0003879_abnormal_hair_cell1.89145266
48MP0000767_abnormal_smooth_muscle1.80543835
49MP0004272_abnormal_basement_membrane1.79235041
50MP0002572_abnormal_emotion/affect_behav1.78279461
51MP0002876_abnormal_thyroid_physiology1.73645637
52MP0006276_abnormal_autonomic_nervous1.67541124
53MP0003787_abnormal_imprinting1.67395038
54MP0002089_abnormal_postnatal_growth/wei1.66758504
55MP0000604_amyloidosis1.65887452
56MP0001440_abnormal_grooming_behavior1.65454925
57MP0003045_fibrosis1.63648389
58MP0000013_abnormal_adipose_tissue1.63619051
59MP0004233_abnormal_muscle_weight1.55558863
60MP0010368_abnormal_lymphatic_system1.55138990
61MP0003191_abnormal_cellular_cholesterol1.52413672
62MP0005646_abnormal_pituitary_gland1.52180180
63MP0002067_abnormal_sensory_capabilities1.51093926
64MP0005623_abnormal_meninges_morphology1.49365318
65MP0001486_abnormal_startle_reflex1.49203014
66MP0009384_cardiac_valve_regurgitation1.48802124
67MP0005379_endocrine/exocrine_gland_phen1.43894963
68MP0000733_abnormal_muscle_development1.42057609
69MP0002998_abnormal_bone_remodeling1.41714293
70MP0005058_abnormal_lysosome_morphology1.40091106
71MP0004947_skin_inflammation1.39671369
72MP0005023_abnormal_wound_healing1.38316756
73MP0000678_abnormal_parathyroid_gland1.37838957
74MP0001944_abnormal_pancreas_morphology1.34794393
75MP0000751_myopathy1.34082535
76MP0005535_abnormal_body_temperature1.33426928
77MP0002249_abnormal_larynx_morphology1.32638406
78MP0003453_abnormal_keratinocyte_physiol1.32299879
79MP0005360_urolithiasis1.32070654
80MP0002184_abnormal_innervation1.31899794
81MP0008961_abnormal_basal_metabolism1.31384905
82MP0002557_abnormal_social/conspecific_i1.30370205
83MP0001502_abnormal_circadian_rhythm1.29980781
84MP0000955_abnormal_spinal_cord1.29748189
85MP0002896_abnormal_bone_mineralization1.23835263
86MP0003122_maternal_imprinting1.22498603
87MP0004811_abnormal_neuron_physiology1.22205871
88MP0004043_abnormal_pH_regulation1.21261218
89MP0009278_abnormal_bone_marrow1.21106927
90MP0000538_abnormal_urinary_bladder1.15668357
91MP0003633_abnormal_nervous_system1.15448573
92MP0008569_lethality_at_weaning1.14010175
93MP0003828_pulmonary_edema1.09888356
94MP0003634_abnormal_glial_cell1.08941644
95MP0003300_gastrointestinal_ulcer1.08884237
96MP0001299_abnormal_eye_distance/1.08504623
97MP0002078_abnormal_glucose_homeostasis1.07291640
98MP0005666_abnormal_adipose_tissue1.04469773
99MP0006138_congestive_heart_failure1.04326649
100MP0002638_abnormal_pupillary_reflex1.03746734
101MP0005375_adipose_tissue_phenotype1.03488846
102MP0002066_abnormal_motor_capabilities/c1.02994511
103MP0005257_abnormal_intraocular_pressure1.01223995
104MP0002882_abnormal_neuron_morphology1.00767104
105MP0002229_neurodegeneration0.98440916
106MP0003303_peritoneal_inflammation0.97990070
107MP0001533_abnormal_skeleton_physiology0.94847646
108MP0000778_abnormal_nervous_system0.94094795
109MP0005508_abnormal_skeleton_morphology0.92574990
110MP0002069_abnormal_eating/drinking_beha0.90635852
111MP0001915_intracranial_hemorrhage0.90557235
112MP0002822_catalepsy0.90249132
113MP0004130_abnormal_muscle_cell0.89715133
114MP0003690_abnormal_glial_cell0.87413093
115MP0000858_altered_metastatic_potential0.87409823
116MP0004924_abnormal_behavior0.87406100
117MP0005386_behavior/neurological_phenoty0.87406100
118MP0006072_abnormal_retinal_apoptosis0.87244783
119MP0004381_abnormal_hair_follicle0.86866215
120MP0005503_abnormal_tendon_morphology0.86404857
121MP0004145_abnormal_muscle_electrophysio0.85888491
122MP0005390_skeleton_phenotype0.83636512
123MP0000003_abnormal_adipose_tissue0.83436107
124MP0005621_abnormal_cell_physiology0.82600277
125MP0001851_eye_inflammation0.81635481
126MP0000759_abnormal_skeletal_muscle0.81512396
127MP0002419_abnormal_innate_immunity0.81464051
128MP0010234_abnormal_vibrissa_follicle0.79476196
129MP0010630_abnormal_cardiac_muscle0.78902379
130MP0000747_muscle_weakness0.78034823
131MP0001270_distended_abdomen0.76642510
132MP0004742_abnormal_vestibular_system0.76254980
133MP0003631_nervous_system_phenotype0.76108914
134MP0002837_dystrophic_cardiac_calcinosis0.75934010
135MP0002933_joint_inflammation0.75882786
136MP0008874_decreased_physiological_sensi0.75743894
137MP0002928_abnormal_bile_duct0.75620469
138MP0006082_CNS_inflammation0.75593020
139MP0001614_abnormal_blood_vessel0.75397492
140MP0005670_abnormal_white_adipose0.75135306
141MP0002060_abnormal_skin_morphology0.74978666
142MP0003953_abnormal_hormone_level0.74423820
143MP0010030_abnormal_orbit_morphology0.74301040
144MP0001346_abnormal_lacrimal_gland0.73683274
145MP0000750_abnormal_muscle_regeneration0.73198714
146MP0004087_abnormal_muscle_fiber0.72624237
147MP0003329_amyloid_beta_deposits0.71278111
148MP0005248_abnormal_Harderian_gland0.70844315
149MP0002138_abnormal_hepatobiliary_system0.70120313
150MP0000920_abnormal_myelination0.69905547
151MP0003075_altered_response_to0.69897995
152MP0005275_abnormal_skin_tensile0.69803615
153MP0000371_diluted_coat_color0.69695073
154MP0002090_abnormal_vision0.69663315
155MP0002925_abnormal_cardiovascular_devel0.67410734
156MP0003942_abnormal_urinary_system0.67254177
157MP0001790_abnormal_immune_system0.67084789
158MP0005387_immune_system_phenotype0.67084789
159MP0003115_abnormal_respiratory_system0.65482539
160MP0001963_abnormal_hearing_physiology0.64407354
161MP0004185_abnormal_adipocyte_glucose0.63887860
162MP0008004_abnormal_stomach_pH0.62693674
163MP0005464_abnormal_platelet_physiology0.62512374
164MP0000631_abnormal_neuroendocrine_gland0.62332646
165MP0002113_abnormal_skeleton_development0.62143595
166MP0002932_abnormal_joint_morphology0.61625599
167MP0001765_abnormal_ion_homeostasis0.61080345
168MP0005448_abnormal_energy_balance0.60597335
169MP0003868_abnormal_feces_composition0.59617983
170MP0003795_abnormal_bone_structure0.59162768
171MP0000249_abnormal_blood_vessel0.58666474
172MP0002108_abnormal_muscle_morphology0.58508604
173MP0005595_abnormal_vascular_smooth0.58299637
174MP0000534_abnormal_ureter_morphology0.56831836
175MP0004808_abnormal_hematopoietic_stem0.54478309
176MP0002168_other_aberrant_phenotype0.53883362
177MP0000462_abnormal_digestive_system0.52488188
178MP0000015_abnormal_ear_pigmentation0.51271727
179MP0000428_abnormal_craniofacial_morphol0.50978008
180MP0002128_abnormal_blood_circulation0.50724320
181MP0003632_abnormal_nervous_system0.49054681

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.54565342
2Protrusio acetabuli (HP:0003179)4.21594883
3Myokymia (HP:0002411)4.17249452
4Atonic seizures (HP:0010819)4.07470050
5Visual hallucinations (HP:0002367)3.91484526
6Supranuclear gaze palsy (HP:0000605)3.89582549
7Focal motor seizures (HP:0011153)3.89569538
8Abnormality of calcium-phosphate metabolism (HP:0100530)3.79246682
9Focal seizures (HP:0007359)3.56050249
10Progressive cerebellar ataxia (HP:0002073)3.52178308
11Hyperinsulinemic hypoglycemia (HP:0000825)3.48172833
12Decreased circulating renin level (HP:0003351)3.20242888
13Febrile seizures (HP:0002373)3.19976747
14Premature rupture of membranes (HP:0001788)3.19767037
15Action tremor (HP:0002345)3.11775178
16Hypothermia (HP:0002045)3.08830056
17Absence seizures (HP:0002121)2.97195627
18Dysostosis multiplex (HP:0000943)2.96306015
19Urinary glycosaminoglycan excretion (HP:0003541)2.91297288
20Mucopolysacchariduria (HP:0008155)2.91297288
21Hypercortisolism (HP:0001578)2.83469238
22Epileptic encephalopathy (HP:0200134)2.82313876
23Obstructive sleep apnea (HP:0002870)2.82223060
24Generalized tonic-clonic seizures (HP:0002069)2.82184872
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.82077194
26Abnormality of polysaccharide metabolism (HP:0011012)2.82077194
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.82077194
28Abnormality of liposaccharide metabolism (HP:0010968)2.77504041
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.77504041
30Abnormality of glycolipid metabolism (HP:0010969)2.77504041
31Hyperacusis (HP:0010780)2.73241340
32Urethral obstruction (HP:0000796)2.73079411
33Thin bony cortex (HP:0002753)2.72550781
34Shallow orbits (HP:0000586)2.71490839
35Hypoglycemic seizures (HP:0002173)2.68999763
36Cervical subluxation (HP:0003308)2.68006618
37Retinal atrophy (HP:0001105)2.66446906
38Insulin-resistant diabetes mellitus (HP:0000831)2.65922050
39Ulnar bowing (HP:0003031)2.63421055
40Agitation (HP:0000713)2.62128030
41Dialeptic seizures (HP:0011146)2.58345424
42Broad face (HP:0000283)2.57165946
43Symptomatic seizures (HP:0011145)2.55619182
44Cortical visual impairment (HP:0100704)2.53836840
45Failure to thrive in infancy (HP:0001531)2.53393172
46Macroorchidism (HP:0000053)2.50163210
47Disproportionate tall stature (HP:0001519)2.47885371
48Nuclear cataract (HP:0100018)2.45870456
49Vascular tortuosity (HP:0004948)2.42922762
50Deep venous thrombosis (HP:0002625)2.42864391
51Ankle clonus (HP:0011448)2.41249421
52EEG with generalized epileptiform discharges (HP:0011198)2.41159355
53Neuronal loss in central nervous system (HP:0002529)2.41159236
54Aneurysm (HP:0002617)2.37007563
55Epileptiform EEG discharges (HP:0011182)2.36380538
56Papilledema (HP:0001085)2.34334821
57Ulnar claw (HP:0001178)2.33876508
58Hypsarrhythmia (HP:0002521)2.32530941
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32146493
60Increased connective tissue (HP:0009025)2.28237288
61Atrophic scars (HP:0001075)2.28137412
62Neurofibrillary tangles (HP:0002185)2.23533581
63Vertebral compression fractures (HP:0002953)2.22996759
64Upper limb amyotrophy (HP:0009129)2.21372031
65Distal upper limb amyotrophy (HP:0007149)2.21372031
66Genetic anticipation (HP:0003743)2.20109290
67Blue sclerae (HP:0000592)2.19913760
68Mutism (HP:0002300)2.18638577
69Mitral regurgitation (HP:0001653)2.18208345
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.17663660
71Depression (HP:0000716)2.16479656
72Coxa vara (HP:0002812)2.16160644
73Aortic aneurysm (HP:0004942)2.15728850
74Postural instability (HP:0002172)2.14922589
75Cupped ribs (HP:0000887)2.14803192
76Urinary bladder sphincter dysfunction (HP:0002839)2.11429887
77Bradycardia (HP:0001662)2.11233970
78Ankle contracture (HP:0006466)2.09662811
79Wormian bones (HP:0002645)2.08979224
80Hemiparesis (HP:0001269)2.07749542
81Dysmetria (HP:0001310)2.07557381
82Mitral stenosis (HP:0001718)2.07260844
83Biconcave vertebral bodies (HP:0004586)2.06933037
84Distal lower limb amyotrophy (HP:0008944)2.05716772
85Pancreatic islet-cell hyperplasia (HP:0004510)2.05589606
86Abnormality of endocrine pancreas physiology (HP:0012093)2.05404378
87Abnormality of the pancreatic islet cells (HP:0006476)2.05404378
88Truncal ataxia (HP:0002078)2.03545057
89Impaired vibration sensation in the lower limbs (HP:0002166)2.01852501
90Pheochromocytoma (HP:0002666)2.00862882
91Peritonitis (HP:0002586)2.00776015
92Aortic dissection (HP:0002647)1.99432047
93Bowed forearm bones (HP:0003956)1.98488309
94Bowing of the arm (HP:0006488)1.98488309
95Dilatation of the ascending aorta (HP:0005111)1.98074695
96Hyperkalemia (HP:0002153)1.98001303
97Hemorrhage of the eye (HP:0011885)1.97903359
98Cerebral inclusion bodies (HP:0100314)1.97416422
99Resting tremor (HP:0002322)1.96629609
100Long palpebral fissure (HP:0000637)1.96581054
101Oligomenorrhea (HP:0000876)1.96423690
102Bladder diverticulum (HP:0000015)1.96192368
103Spastic gait (HP:0002064)1.95631512
104Hyperglycemia (HP:0003074)1.94708981
105Increased cerebral lipofuscin (HP:0011813)1.94588069
106Dysautonomia (HP:0002459)1.93802284
107Hemiplegia (HP:0002301)1.91153330
108Abnormality of renin-angiotensin system (HP:0000847)1.90277154
109Large for gestational age (HP:0001520)1.89832182
110Hypoplasia of the iris (HP:0007676)1.89574528
111Spinal rigidity (HP:0003306)1.89503569
112Fragile skin (HP:0001030)1.88688614
113Insidious onset (HP:0003587)1.87968339
114Termporal pattern (HP:0011008)1.87968339
115Lymphangioma (HP:0100764)1.86521421
116Wrist flexion contracture (HP:0001239)1.84442424
117Mitral valve prolapse (HP:0001634)1.84123344
118Broad metatarsal (HP:0001783)1.83382037
119Flat acetabular roof (HP:0003180)1.82825879
120Cerebral aneurysm (HP:0004944)1.81754903
121Lumbar hyperlordosis (HP:0002938)1.81597232
122Orthostatic hypotension (HP:0001278)1.80722270
123Tibial bowing (HP:0002982)1.80530272
124Genu recurvatum (HP:0002816)1.79724151
125Turricephaly (HP:0000262)1.79561523
126Psychosis (HP:0000709)1.79522118
127Abnormal autonomic nervous system physiology (HP:0012332)1.79383632
128Split foot (HP:0001839)1.79009784
129Adrenal overactivity (HP:0002717)1.78941890
130Joint laxity (HP:0001388)1.78635151
131Diplopia (HP:0000651)1.78295543
132Abnormality of binocular vision (HP:0011514)1.78295543
133Supernumerary nipples (HP:0002558)1.78114838
134Joint stiffness (HP:0001387)1.78084451
135J-shaped sella turcica (HP:0002680)1.77923690
136Scanning speech (HP:0002168)1.77168471
137Exotropia (HP:0000577)1.76856089
138Abnormality of carpal bone ossification (HP:0006257)1.76462390
139Onion bulb formation (HP:0003383)1.75945639
140Arterial tortuosity (HP:0005116)1.75779186
141Amblyopia (HP:0000646)1.75518273
142Menstrual irregularities (HP:0000858)1.75093076
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.74615203
144Impaired smooth pursuit (HP:0007772)1.74569448
145Abnormal pancreas size (HP:0012094)1.73852145
146Abnormality of complement system (HP:0005339)1.73304117
147Postural tremor (HP:0002174)1.73194307
148Broad palm (HP:0001169)1.73003452
149Hypoventilation (HP:0002791)1.72685821
150Abnormal ossification of hand bones (HP:0005921)1.71804441
151Increased variability in muscle fiber diameter (HP:0003557)1.71594911
152Pointed chin (HP:0000307)1.71358165
153Hyperparathyroidism (HP:0000843)1.71035054
154Long eyelashes (HP:0000527)1.70757817
155Xerostomia (HP:0000217)1.70608387
156Recurrent cutaneous fungal infections (HP:0011370)1.69726276
157Chronic mucocutaneous candidiasis (HP:0002728)1.69726276
158Esophageal varix (HP:0002040)1.69632723
159Hypokalemia (HP:0002900)1.69320657
160Spondylolisthesis (HP:0003302)1.69090612
161Widely spaced teeth (HP:0000687)1.68724422
162Hand muscle atrophy (HP:0009130)1.68549902
163Atelectasis (HP:0100750)1.67757474
164Lower limb muscle weakness (HP:0007340)1.67418787
165Arnold-Chiari malformation (HP:0002308)1.67378978
166Back pain (HP:0003418)1.65517599
167Distal lower limb muscle weakness (HP:0009053)1.64199715
168Metaphyseal cupping (HP:0003021)1.61605853
169Lower limb amyotrophy (HP:0007210)1.60489617
170Abnormality of the fingertips (HP:0001211)1.60422164
171Achilles tendon contracture (HP:0001771)1.60373935
172Abnormality of dentin (HP:0010299)1.60332042
173Hyperextensible skin (HP:0000974)1.60292187
174Persistence of primary teeth (HP:0006335)1.59971099
175Syringomyelia (HP:0003396)1.59289642
176Spinal cord lesions (HP:0100561)1.59289642
177Venous abnormality (HP:0002624)1.58371343
178Flared iliac wings (HP:0002869)1.56836531
179Emphysema (HP:0002097)1.56824616
180Abnormality of the Achilles tendon (HP:0005109)1.56531988
181Spinal canal stenosis (HP:0003416)1.56040614
182Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.56007467
183Complement deficiency (HP:0004431)1.54365031
184Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.54124190
185Short 4th metacarpal (HP:0010044)1.54124190
186Ectopia lentis (HP:0001083)1.53268475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.28596196
2PRPF4B4.10493762
3INSRR3.86561755
4NTRK33.83125921
5SIK12.88990985
6RIPK42.86162796
7ERN12.70942545
8MAP3K22.52059903
9MAP3K92.50716102
10NTRK12.50093203
11ICK2.41109868
12MAPK152.32287954
13CAMK1G2.30894914
14CDK121.96086208
15PRKD31.93243245
16GRK51.78775315
17CAMK1D1.76602395
18MAP3K41.73807116
19FGFR41.70975289
20SIK21.69370657
21SMG11.69074496
22IRAK31.65878202
23PKN21.64647655
24PAK61.64035350
25CDC42BPA1.61133757
26TYRO31.60494006
27MAP2K31.59433267
28DAPK21.57358114
29TTN1.57308459
30TAOK21.57226904
31EPHA31.55047375
32EEF2K1.52332220
33MAP3K131.51351762
34MINK11.47188943
35CAMKK21.46381523
36TAOK31.43195823
37GRK71.42037798
38HIPK21.39735646
39ARAF1.33604780
40RET1.31187662
41WNK11.31050038
42DDR21.29660343
43KSR21.29267657
44MOS1.26277108
45MAP3K71.22517788
46JAK11.19718568
47UHMK11.19139634
48MTOR1.17918121
49CAMKK11.12719718
50PRKCH1.11832721
51CDK51.10769903
52EPHA41.10612040
53MAP3K11.09531487
54FES1.08876643
55MARK11.07739748
56PNCK1.06764053
57MAP3K61.02214555
58BMPR21.00545504
59MAP2K71.00260260
60MAP3K30.99959002
61PTK20.99734744
62LATS20.99482759
63MAP3K140.99083228
64EPHB10.98904668
65TAOK10.96075451
66NTRK20.94192755
67IRAK20.90677625
68DYRK1B0.90023005
69SCYL20.89990727
70MAP4K10.85032746
71ZAP700.84600661
72RPS6KC10.82802694
73RPS6KL10.82802694
74MAPK130.82441467
75CASK0.82284538
76RPS6KA20.81229665
77EPHB20.78928874
78RIPK10.77650694
79WNK40.76820002
80KSR10.75995305
81MAP3K110.75944971
82PRKCE0.75828059
83STK380.75492699
84MARK20.74767578
85FGFR30.71727159
86MAP2K40.70843478
87PDPK10.69041142
88STK110.68860620
89RAF10.68551988
90FER0.67674749
91PDGFRA0.65732661
92ALK0.64949533
93PRKD20.64711984
94SGK4940.64372327
95SGK2230.64372327
96MAPK100.63586384
97PAK30.63132654
98MAPK120.62733324
99JAK20.61690237
100MET0.61430968
101PASK0.60993769
102SGK10.60381849
103RPS6KA60.60194198
104CAMK10.59520616
105MAPK70.59392664
106PKN10.57989288
107BMX0.57082984
108FRK0.54844603
109CHUK0.54379256
110PTK60.54209070
111TNK20.54087542
112TYK20.54078693
113NME10.53953094
114CAMK40.53952052
115SIK30.52005237
116SGK30.51992789
117PDGFRB0.51895297
118IRAK10.51356911
119PDK10.51260168
120PIM20.51256775
121DMPK0.49952577
122EPHA20.49375081
123HCK0.48812587
124MAP3K100.48517420
125CSK0.48365534
126CAMK2A0.47886525
127SGK20.47842340
128TBK10.47403152
129PAK20.47156688
130PRKCG0.46435907
131PRKCZ0.45443252
132JAK30.45111770
133BRAF0.45068764
134NEK60.44607278
135LMTK20.44594869
136FYN0.41583193
137DYRK1A0.41007310
138IRAK40.40983522
139PHKG20.40905638
140PHKG10.40905638
141FGR0.40761693
142PAK40.40634286
143TGFBR20.40355025
144RPS6KA30.39897267
145CSF1R0.39252992
146BLK0.38769327
147MATK0.38585500
148MAP2K10.37331821
149SRC0.36950310
150TNIK0.36207196
151CAMK2B0.35410012

Predicted pathways (KEGG)

RankGene SetZ-score
1Insulin secretion_Homo sapiens_hsa049112.44677682
2Synaptic vesicle cycle_Homo sapiens_hsa047212.39179035
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.38414644
4Type II diabetes mellitus_Homo sapiens_hsa049302.24924723
5Taste transduction_Homo sapiens_hsa047422.05441910
6Chronic myeloid leukemia_Homo sapiens_hsa052201.79421560
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78864955
8Morphine addiction_Homo sapiens_hsa050321.77428371
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77287020
10Cholinergic synapse_Homo sapiens_hsa047251.76277664
11Circadian entrainment_Homo sapiens_hsa047131.75154311
12GABAergic synapse_Homo sapiens_hsa047271.74582292
13Amphetamine addiction_Homo sapiens_hsa050311.74015305
14Nicotine addiction_Homo sapiens_hsa050331.72521930
15Long-term potentiation_Homo sapiens_hsa047201.70174587
16Collecting duct acid secretion_Homo sapiens_hsa049661.70034636
17Olfactory transduction_Homo sapiens_hsa047401.68135552
18Glutamatergic synapse_Homo sapiens_hsa047241.64936599
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64088657
20Acute myeloid leukemia_Homo sapiens_hsa052211.63255104
21Salivary secretion_Homo sapiens_hsa049701.60322797
22Dopaminergic synapse_Homo sapiens_hsa047281.57173994
23Notch signaling pathway_Homo sapiens_hsa043301.57088550
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56082670
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55831474
26Cocaine addiction_Homo sapiens_hsa050301.52880001
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50008406
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45145457
29Serotonergic synapse_Homo sapiens_hsa047261.41626132
30Vibrio cholerae infection_Homo sapiens_hsa051101.41268455
31Focal adhesion_Homo sapiens_hsa045101.40777285
32Gastric acid secretion_Homo sapiens_hsa049711.38511662
33Renin secretion_Homo sapiens_hsa049241.38102662
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35493389
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35446861
36Endometrial cancer_Homo sapiens_hsa052131.34874273
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32642087
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31308238
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27119166
40Lysosome_Homo sapiens_hsa041421.24026633
41Amoebiasis_Homo sapiens_hsa051461.23486200
42Estrogen signaling pathway_Homo sapiens_hsa049151.22945034
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22767848
44Pancreatic cancer_Homo sapiens_hsa052121.22749869
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.22673129
46ECM-receptor interaction_Homo sapiens_hsa045121.21089825
47Long-term depression_Homo sapiens_hsa047301.20808318
48Type I diabetes mellitus_Homo sapiens_hsa049401.17592262
49GnRH signaling pathway_Homo sapiens_hsa049121.14277137
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.13884418
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13592184
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10345352
53Proteoglycans in cancer_Homo sapiens_hsa052051.06101139
54Oxytocin signaling pathway_Homo sapiens_hsa049211.05978759
55Dorso-ventral axis formation_Homo sapiens_hsa043201.05456235
56Pancreatic secretion_Homo sapiens_hsa049721.02773529
57Bladder cancer_Homo sapiens_hsa052191.02151823
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00413640
59cAMP signaling pathway_Homo sapiens_hsa040241.00071154
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99349270
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98158183
62Small cell lung cancer_Homo sapiens_hsa052220.97484582
63Thyroid hormone synthesis_Homo sapiens_hsa049180.95946018
64Calcium signaling pathway_Homo sapiens_hsa040200.95843176
65Hepatitis B_Homo sapiens_hsa051610.95668381
66Complement and coagulation cascades_Homo sapiens_hsa046100.94190876
67TNF signaling pathway_Homo sapiens_hsa046680.92990363
68Glioma_Homo sapiens_hsa052140.92259778
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87695969
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87224209
71Gap junction_Homo sapiens_hsa045400.85922409
72Hepatitis C_Homo sapiens_hsa051600.85805989
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.85724461
74Prolactin signaling pathway_Homo sapiens_hsa049170.85714085
75Adherens junction_Homo sapiens_hsa045200.84240710
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.84226203
77MicroRNAs in cancer_Homo sapiens_hsa052060.83904815
78Other glycan degradation_Homo sapiens_hsa005110.83585814
79Toxoplasmosis_Homo sapiens_hsa051450.83526916
80Rheumatoid arthritis_Homo sapiens_hsa053230.82674323
81AMPK signaling pathway_Homo sapiens_hsa041520.81894156
82Chemokine signaling pathway_Homo sapiens_hsa040620.81845044
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.81180092
84HIF-1 signaling pathway_Homo sapiens_hsa040660.80007189
85Prostate cancer_Homo sapiens_hsa052150.79466099
86Colorectal cancer_Homo sapiens_hsa052100.77647159
87Osteoclast differentiation_Homo sapiens_hsa043800.77208726
88Melanogenesis_Homo sapiens_hsa049160.77103175
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75768393
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.75399708
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.75084193
92T cell receptor signaling pathway_Homo sapiens_hsa046600.74786603
93ErbB signaling pathway_Homo sapiens_hsa040120.73960569
94Lysine degradation_Homo sapiens_hsa003100.73026110
95FoxO signaling pathway_Homo sapiens_hsa040680.72938917
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71394248
97Thyroid cancer_Homo sapiens_hsa052160.70020493
98MAPK signaling pathway_Homo sapiens_hsa040100.69586083
99Inositol phosphate metabolism_Homo sapiens_hsa005620.69326790
100Platelet activation_Homo sapiens_hsa046110.68837157
101Glucagon signaling pathway_Homo sapiens_hsa049220.68686334
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68568842
103Prion diseases_Homo sapiens_hsa050200.68449153
104mTOR signaling pathway_Homo sapiens_hsa041500.68277327
105Choline metabolism in cancer_Homo sapiens_hsa052310.66178588
106Bile secretion_Homo sapiens_hsa049760.66118281
107Insulin resistance_Homo sapiens_hsa049310.65263828
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63311843
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.63140269
110Leishmaniasis_Homo sapiens_hsa051400.62359444
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61533718
112Phagosome_Homo sapiens_hsa041450.61434130
113Fructose and mannose metabolism_Homo sapiens_hsa000510.61319193
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61182283
115Influenza A_Homo sapiens_hsa051640.60564500
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59833495
117Axon guidance_Homo sapiens_hsa043600.58534713
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58501199
119Renal cell carcinoma_Homo sapiens_hsa052110.58435037
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58407337
121Apoptosis_Homo sapiens_hsa042100.58214146
122Ras signaling pathway_Homo sapiens_hsa040140.57448085
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56984569
124Pertussis_Homo sapiens_hsa051330.56401686
125Tuberculosis_Homo sapiens_hsa051520.56149924
126Insulin signaling pathway_Homo sapiens_hsa049100.55671074
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55491998
128VEGF signaling pathway_Homo sapiens_hsa043700.55125919
129Pathways in cancer_Homo sapiens_hsa052000.54683341
130Endocytosis_Homo sapiens_hsa041440.53505749
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50526707
132Circadian rhythm_Homo sapiens_hsa047100.50229182
133Sulfur metabolism_Homo sapiens_hsa009200.46713912
134Rap1 signaling pathway_Homo sapiens_hsa040150.45733376
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45714930
136Ovarian steroidogenesis_Homo sapiens_hsa049130.45419740
137African trypanosomiasis_Homo sapiens_hsa051430.44024659
138B cell receptor signaling pathway_Homo sapiens_hsa046620.43913144
139Sphingolipid metabolism_Homo sapiens_hsa006000.42309682
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41894211
141Dilated cardiomyopathy_Homo sapiens_hsa054140.40967116
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40457989
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40133076
144Protein export_Homo sapiens_hsa030600.39356433
145Non-small cell lung cancer_Homo sapiens_hsa052230.35310126

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