USP31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.29326787
2axon ensheathment in central nervous system (GO:0032291)5.21198317
3central nervous system myelination (GO:0022010)5.21198317
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.85391420
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65452550
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46618231
7synaptic vesicle exocytosis (GO:0016079)4.36933856
8neuronal action potential propagation (GO:0019227)4.34707936
9locomotory exploration behavior (GO:0035641)4.33873540
10glutamate secretion (GO:0014047)4.33447596
11regulation of synaptic vesicle exocytosis (GO:2000300)4.30367837
12mitotic sister chromatid cohesion (GO:0007064)4.11220337
13regulation of neuronal synaptic plasticity (GO:0048168)3.91119166
14vocalization behavior (GO:0071625)3.90119694
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.87167116
16L-amino acid import (GO:0043092)3.85264576
17neuron cell-cell adhesion (GO:0007158)3.83292789
18layer formation in cerebral cortex (GO:0021819)3.79869234
19dendritic spine morphogenesis (GO:0060997)3.73991039
20regulation of synaptic vesicle transport (GO:1902803)3.73364392
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.69451922
22establishment of mitochondrion localization (GO:0051654)3.69236420
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.69227005
24cellular potassium ion homeostasis (GO:0030007)3.62096077
25glycine transport (GO:0015816)3.61432042
26negative regulation of neurotransmitter transport (GO:0051589)3.59386278
27regulation of glutamate receptor signaling pathway (GO:1900449)3.55607556
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52209934
29protein localization to synapse (GO:0035418)3.49986207
30neurotransmitter secretion (GO:0007269)3.48207624
31protein heterotetramerization (GO:0051290)3.45651937
32regulation of meiosis I (GO:0060631)3.43663517
33nerve growth factor signaling pathway (GO:0038180)3.43504892
34cerebellar Purkinje cell differentiation (GO:0021702)3.39093089
35long-chain fatty acid biosynthetic process (GO:0042759)3.38604913
36positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36631614
37neuron recognition (GO:0008038)3.34816802
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30328896
39adult walking behavior (GO:0007628)3.30257882
40glutamate receptor signaling pathway (GO:0007215)3.29390787
41exploration behavior (GO:0035640)3.29129229
42neuron-neuron synaptic transmission (GO:0007270)3.28665105
43sodium ion export (GO:0071436)3.28032785
44replication fork processing (GO:0031297)3.27310779
45synaptic transmission, glutamatergic (GO:0035249)3.25339503
46dendrite morphogenesis (GO:0048813)3.24295811
47pyrimidine nucleobase catabolic process (GO:0006208)3.24051245
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21749445
49axonal fasciculation (GO:0007413)3.16290041
50negative regulation of neurotransmitter secretion (GO:0046929)3.14974869
51presynaptic membrane organization (GO:0097090)3.14473360
52gamma-aminobutyric acid transport (GO:0015812)3.14434000
53transmission of nerve impulse (GO:0019226)3.13939669
54neuromuscular process controlling balance (GO:0050885)3.12577724
55organelle transport along microtubule (GO:0072384)3.12118460
56long-term memory (GO:0007616)3.11610335
57neuromuscular process controlling posture (GO:0050884)3.11265022
58vesicle transport along microtubule (GO:0047496)3.09919428
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07323172
60neurotransmitter transport (GO:0006836)3.05563140
61regulation of synaptic plasticity (GO:0048167)3.05507808
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03827746
63myelination (GO:0042552)3.01857647
64regulation of synapse structural plasticity (GO:0051823)3.01540872
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01385697
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.00812393
67axon ensheathment (GO:0008366)3.00009349
68ensheathment of neurons (GO:0007272)3.00009349
69auditory behavior (GO:0031223)2.98952592
70regulation of postsynaptic membrane potential (GO:0060078)2.96325875
71proline transport (GO:0015824)2.95741455
72amino acid import (GO:0043090)2.95725681
73atrial cardiac muscle cell action potential (GO:0086014)2.95576453
74regulation of ARF protein signal transduction (GO:0032012)2.95326828
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94103045
76potassium ion import (GO:0010107)2.92931282
77mechanosensory behavior (GO:0007638)2.92344279
78regulation of neurotransmitter secretion (GO:0046928)2.92337759
79long-term synaptic potentiation (GO:0060291)2.91511995
80limb bud formation (GO:0060174)2.90920032
81regulation of dendritic spine morphogenesis (GO:0061001)2.90847636
82neuron remodeling (GO:0016322)2.90716302
83presynaptic membrane assembly (GO:0097105)2.89013902
84membrane hyperpolarization (GO:0060081)2.88601591
85membrane depolarization during action potential (GO:0086010)2.88122723
86activation of protein kinase A activity (GO:0034199)2.85690629
87response to auditory stimulus (GO:0010996)2.85627313
88myelin maintenance (GO:0043217)2.85602458
89exocrine pancreas development (GO:0031017)2.84322845
90neuronal ion channel clustering (GO:0045161)2.83815522
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.82674285
92regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.82488667
93detection of temperature stimulus involved in sensory perception (GO:0050961)2.82072641
94detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.82072641
95mating behavior (GO:0007617)2.81277586
96response to methylmercury (GO:0051597)2.80568342
97protein K11-linked deubiquitination (GO:0035871)2.79924539
98regulation of neurotransmitter transport (GO:0051588)2.79834728
99synaptic vesicle endocytosis (GO:0048488)2.79561377
100positive regulation of membrane potential (GO:0045838)2.79248687
101negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79132774
102negative regulation of translation, ncRNA-mediated (GO:0040033)2.79132774
103regulation of translation, ncRNA-mediated (GO:0045974)2.79132774
104regulation of voltage-gated calcium channel activity (GO:1901385)2.77761339
105resolution of meiotic recombination intermediates (GO:0000712)2.77063774
106innervation (GO:0060384)2.75252131
107sister chromatid cohesion (GO:0007062)2.75049626
108neuromuscular process (GO:0050905)2.74509757
109regulation of synaptic transmission, glutamatergic (GO:0051966)2.71964543
110establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.71822130
111mitochondrion transport along microtubule (GO:0047497)2.71822130
112membrane depolarization (GO:0051899)2.71403836
113regulation of neurotransmitter levels (GO:0001505)2.70354539
114central nervous system projection neuron axonogenesis (GO:0021952)2.69442826
115positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68220874
116positive regulation of potassium ion transport (GO:0043268)2.67142129
117positive regulation of amino acid transport (GO:0051957)2.65333202
118cerebral cortex radially oriented cell migration (GO:0021799)2.62909134
119nucleobase catabolic process (GO:0046113)2.62703516
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.62576973
121positive regulation of glycolytic process (GO:0045821)2.58106652
122response to pheromone (GO:0019236)2.57987842
123positive regulation of meiosis (GO:0045836)2.56254979
124anterior/posterior axis specification, embryo (GO:0008595)2.55202366
125acrosome assembly (GO:0001675)2.55015723
126regulation of DNA endoreduplication (GO:0032875)2.53577484
127postsynaptic membrane organization (GO:0001941)2.51049040
128genitalia morphogenesis (GO:0035112)2.50460010
129DNA double-strand break processing (GO:0000729)2.50422468
130central nervous system neuron axonogenesis (GO:0021955)2.47222917
131positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.47214889
132negative regulation of dendrite development (GO:2000171)2.46987452
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46807512
134lymphangiogenesis (GO:0001946)2.45810136
135negative regulation of keratinocyte proliferation (GO:0010839)2.44879154
136positive regulation of protein autophosphorylation (GO:0031954)2.42324418
137negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.39660454
138positive regulation of meiotic cell cycle (GO:0051446)2.39205906
139synapsis (GO:0007129)2.38519943
140regulation of keratinocyte proliferation (GO:0010837)2.37861358
141negative regulation of activin receptor signaling pathway (GO:0032926)2.37668478
142regulation of dendritic spine development (GO:0060998)2.37437465
143regulation of centriole replication (GO:0046599)2.36930355
144kidney morphogenesis (GO:0060993)2.34129203
145male meiosis (GO:0007140)2.34076864
146olfactory bulb development (GO:0021772)2.32045555
147regulation of cardiac muscle cell contraction (GO:0086004)2.30753013
148dorsal/ventral axis specification (GO:0009950)2.29231407
149negative regulation of dendrite morphogenesis (GO:0050774)2.29101910
150brain morphogenesis (GO:0048854)2.28559733
151negative regulation of protein localization to cell surface (GO:2000009)2.27582112
152cellular sodium ion homeostasis (GO:0006883)2.27025254
153regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.25296822
154fibroblast migration (GO:0010761)2.25058681
155retina vasculature morphogenesis in camera-type eye (GO:0061299)2.22449031
156regulation of telomere maintenance (GO:0032204)2.21898517
157male sex determination (GO:0030238)2.21063246
158positive regulation of cardiac muscle cell differentiation (GO:2000727)2.19229259
159sympathetic nervous system development (GO:0048485)2.18130168
160neurotransmitter-gated ion channel clustering (GO:0072578)2.17115557
161embryonic retina morphogenesis in camera-type eye (GO:0060059)2.13410669
162regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.13144214
163regulation of nuclear cell cycle DNA replication (GO:0033262)2.12633886
164anatomical structure arrangement (GO:0048532)2.09244222
165C4-dicarboxylate transport (GO:0015740)2.08649964
166artery development (GO:0060840)2.08506860
167activation of protein kinase B activity (GO:0032148)2.08276095
168positive regulation of sodium ion transmembrane transport (GO:1902307)2.08165798
169spinal cord development (GO:0021510)2.06383611
170chemosensory behavior (GO:0007635)2.06284155
171microtubule anchoring (GO:0034453)2.05500289
172regulation of mesoderm development (GO:2000380)2.02956950
173piRNA metabolic process (GO:0034587)2.02904407
174negative regulation of astrocyte differentiation (GO:0048712)2.02308946
175regulation of neuron migration (GO:2001222)2.02272878
176cell communication involved in cardiac conduction (GO:0086065)2.01660008
177cardiac muscle cell action potential (GO:0086001)2.00973674
178regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.00425113
179regulation of sarcomere organization (GO:0060297)1.98758408
180detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)1.98321031
181positive regulation of male gonad development (GO:2000020)1.97705330
182response to nitrosative stress (GO:0051409)1.97485559
183cellular response to sterol (GO:0036315)1.95958013
184renal tubule morphogenesis (GO:0061333)1.95724343
185retinal cone cell development (GO:0046549)1.95697141
186pancreas development (GO:0031016)1.94493752
187regulation of type B pancreatic cell apoptotic process (GO:2000674)1.93917018
188cardiac muscle cell action potential involved in contraction (GO:0086002)1.93893723
189regulation of sodium ion transmembrane transport (GO:1902305)1.93566571
190regulation of non-canonical Wnt signaling pathway (GO:2000050)1.91880632

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08240920
2GBX2_23144817_ChIP-Seq_PC3_Human3.38854806
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.86468614
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74291295
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68877259
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66845834
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50940137
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37887109
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37887109
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.28785971
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27687460
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22496929
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.21994926
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21022854
15DROSHA_22980978_ChIP-Seq_HELA_Human2.20457204
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15668518
17AR_21572438_ChIP-Seq_LNCaP_Human2.12330825
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12236885
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.07685190
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07568654
21VDR_22108803_ChIP-Seq_LS180_Human2.04930722
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01238471
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.98192704
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.95357183
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88636579
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.87732460
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.86503903
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83478841
29EWS_26573619_Chip-Seq_HEK293_Human1.78842573
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78376416
31TAF15_26573619_Chip-Seq_HEK293_Human1.72676788
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72648263
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70339592
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.70187982
35* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68282511
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67910454
37SMAD4_21799915_ChIP-Seq_A2780_Human1.67388238
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66718098
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61906496
40E2F7_22180533_ChIP-Seq_HELA_Human1.57616990
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55288326
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55141797
43* STAT3_23295773_ChIP-Seq_U87_Human1.53441838
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52454450
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47686997
46* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47530177
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.45467071
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.44166400
49* BCAT_22108803_ChIP-Seq_LS180_Human1.42965754
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.42719995
51TP53_16413492_ChIP-PET_HCT116_Human1.42545371
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42464022
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42132725
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41773389
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40993512
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40988892
57P300_19829295_ChIP-Seq_ESCs_Human1.40229769
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39258097
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38748053
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37522081
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.35437289
62CBP_20019798_ChIP-Seq_JUKART_Human1.35408490
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35408490
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34686284
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32723366
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.32252913
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32167006
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32011664
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31102213
70TCF4_22108803_ChIP-Seq_LS180_Human1.30896176
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.30276388
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30234972
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30186427
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29399131
75AHR_22903824_ChIP-Seq_MCF-7_Human1.27714339
76TCF4_23295773_ChIP-Seq_U87_Human1.26066028
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25588317
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24543329
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23144122
80IGF1R_20145208_ChIP-Seq_DFB_Human1.22613156
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21190580
82TP53_18474530_ChIP-ChIP_U2OS_Human1.20861023
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20545834
84AR_19668381_ChIP-Seq_PC3_Human1.20467778
85* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19470245
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18149725
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17521161
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.17109412
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17057291
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.15781897
91AR_25329375_ChIP-Seq_VCAP_Human1.15582146
92P53_22387025_ChIP-Seq_ESCs_Mouse1.15348109
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15100077
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14785912
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14472126
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.14020460
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.13972819
98* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13971579
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.12853769
100SOX9_26525672_Chip-Seq_HEART_Mouse1.12804630
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12557838
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.11980217
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.11825759
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10860039
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10860039
106* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10799524
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.10652874
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10032996
109KDM2B_26808549_Chip-Seq_K562_Human1.08974335
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.08894730
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.07865245
112ER_23166858_ChIP-Seq_MCF-7_Human1.07759894
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07396662
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06946376
115TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06891299
116CDX2_22108803_ChIP-Seq_LS180_Human1.06495068
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.06366156
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05309893
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.05066727
120SMAD3_21741376_ChIP-Seq_ESCs_Human1.03998837
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03644998
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03619960
123FUS_26573619_Chip-Seq_HEK293_Human1.03548818
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03458740
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03100356
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03090353
127* KDM2B_26808549_Chip-Seq_REH_Human1.02620341
128* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02611639
129BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02329608
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01892053
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.01840591
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01714439
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01591193
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00916041
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00877627
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00143676
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00089910
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99413652
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98789230
140RNF2_27304074_Chip-Seq_NSC_Mouse0.98395024
141* RUNX2_22187159_ChIP-Seq_PCA_Human0.97395367
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97018687
143EP300_21415370_ChIP-Seq_HL-1_Mouse0.96892171
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.96690892
145* ZNF274_21170338_ChIP-Seq_K562_Hela0.94234980
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.94070121
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93898578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49686207
2MP0003880_abnormal_central_pattern4.37368114
3MP0004270_analgesia4.02711311
4MP0003635_abnormal_synaptic_transmissio3.60393285
5MP0005423_abnormal_somatic_nervous3.16209212
6MP0009046_muscle_twitch2.98999152
7MP0002064_seizures2.98570263
8MP0009745_abnormal_behavioral_response2.89005292
9MP0002063_abnormal_learning/memory/cond2.88309803
10MP0001486_abnormal_startle_reflex2.74194894
11MP0001968_abnormal_touch/_nociception2.73851433
12MP0002272_abnormal_nervous_system2.71384906
13MP0002734_abnormal_mechanical_nocicepti2.69682267
14MP0008877_abnormal_DNA_methylation2.50000483
15MP0002572_abnormal_emotion/affect_behav2.45095194
16MP0000920_abnormal_myelination2.35253188
17MP0002735_abnormal_chemical_nociception2.33916980
18MP0008057_abnormal_DNA_replication2.26174980
19MP0003329_amyloid_beta_deposits2.08076031
20MP0002736_abnormal_nociception_after2.04920831
21MP0001970_abnormal_pain_threshold2.04394381
22MP0008569_lethality_at_weaning2.03262408
23MP0002733_abnormal_thermal_nociception2.01531984
24MP0000778_abnormal_nervous_system2.00271275
25MP0010368_abnormal_lymphatic_system1.93830341
26MP0004885_abnormal_endolymph1.93119500
27MP0002067_abnormal_sensory_capabilities1.92369739
28MP0010234_abnormal_vibrissa_follicle1.92175790
29MP0009780_abnormal_chondrocyte_physiolo1.91494878
30MP0001440_abnormal_grooming_behavior1.87160618
31MP0004742_abnormal_vestibular_system1.85696015
32MP0001501_abnormal_sleep_pattern1.84563539
33MP0004858_abnormal_nervous_system1.82120032
34MP0002822_catalepsy1.81469713
35MP0003890_abnormal_embryonic-extraembry1.76951117
36MP0000955_abnormal_spinal_cord1.71852374
37MP0002184_abnormal_innervation1.70208415
38MP0004924_abnormal_behavior1.69729496
39MP0005386_behavior/neurological_phenoty1.69729496
40MP0004811_abnormal_neuron_physiology1.68019594
41MP0003633_abnormal_nervous_system1.64195280
42MP0003690_abnormal_glial_cell1.63897218
43MP0001529_abnormal_vocalization1.59947720
44MP0004215_abnormal_myocardial_fiber1.56885767
45MP0005367_renal/urinary_system_phenotyp1.56263329
46MP0000516_abnormal_urinary_system1.56263329
47MP0003937_abnormal_limbs/digits/tail_de1.55644453
48MP0002882_abnormal_neuron_morphology1.51534560
49MP0003631_nervous_system_phenotype1.49704618
50MP0003634_abnormal_glial_cell1.49665982
51MP0002102_abnormal_ear_morphology1.48827379
52MP0002557_abnormal_social/conspecific_i1.48275689
53MP0000383_abnormal_hair_follicle1.46229315
54MP0002066_abnormal_motor_capabilities/c1.45146485
55MP0004142_abnormal_muscle_tone1.39506990
56MP0000427_abnormal_hair_cycle1.37861790
57MP0005171_absent_coat_pigmentation1.34943247
58MP0002229_neurodegeneration1.34296375
59MP0001299_abnormal_eye_distance/1.33692027
60MP0005646_abnormal_pituitary_gland1.33525789
61MP0000566_synostosis1.33174237
62MP0003632_abnormal_nervous_system1.31227056
63MP0006276_abnormal_autonomic_nervous1.29107203
64MP0010030_abnormal_orbit_morphology1.28104189
65MP0003567_abnormal_fetal_cardiomyocyte1.27693490
66MP0003787_abnormal_imprinting1.24605604
67MP0008058_abnormal_DNA_repair1.22413916
68MP0001485_abnormal_pinna_reflex1.21508774
69MP0005645_abnormal_hypothalamus_physiol1.20760866
70MP0005623_abnormal_meninges_morphology1.20321889
71MP0005084_abnormal_gallbladder_morpholo1.20140474
72MP0005409_darkened_coat_color1.20025386
73MP0003941_abnormal_skin_development1.18782747
74MP0002233_abnormal_nose_morphology1.17659310
75MP0000569_abnormal_digit_pigmentation1.16729444
76MP0001905_abnormal_dopamine_level1.15945471
77MP0000579_abnormal_nail_morphology1.15742346
78MP0002837_dystrophic_cardiac_calcinosis1.15429772
79MP0002909_abnormal_adrenal_gland1.15274464
80MP0003718_maternal_effect1.14640255
81MP0003943_abnormal_hepatobiliary_system1.13974231
82MP0002152_abnormal_brain_morphology1.13500570
83MP0010094_abnormal_chromosome_stability1.12698195
84MP0002160_abnormal_reproductive_system1.12421115
85MP0001177_atelectasis1.11431028
86MP0003950_abnormal_plasma_membrane1.10915782
87MP0004084_abnormal_cardiac_muscle1.09605307
88MP0003755_abnormal_palate_morphology1.09511136
89MP0003119_abnormal_digestive_system1.08821069
90MP0006072_abnormal_retinal_apoptosis1.08493411
91MP0004145_abnormal_muscle_electrophysio1.07391313
92MP0003195_calcinosis1.07037017
93MP0002938_white_spotting1.06044395
94MP0001879_abnormal_lymphatic_vessel1.05490521
95MP0006054_spinal_hemorrhage1.05151399
96MP0003935_abnormal_craniofacial_develop1.04544919
97MP0001984_abnormal_olfaction1.01001343
98MP0003137_abnormal_impulse_conducting0.98975802
99MP0005551_abnormal_eye_electrophysiolog0.98208202
100MP0002751_abnormal_autonomic_nervous0.97396187
101MP0004272_abnormal_basement_membrane0.94757717
102MP0000604_amyloidosis0.94579753
103MP0003122_maternal_imprinting0.91907276
104MP0009697_abnormal_copulation0.91384147
105MP0003121_genomic_imprinting0.91006430
106MP0002295_abnormal_pulmonary_circulatio0.90913110
107MP0004043_abnormal_pH_regulation0.90901208
108MP0001963_abnormal_hearing_physiology0.90152805
109MP0003123_paternal_imprinting0.89922705
110MP0008872_abnormal_physiological_respon0.89642964
111MP0001188_hyperpigmentation0.88694383
112MP0002752_abnormal_somatic_nervous0.87347957
113MP0001929_abnormal_gametogenesis0.87178520
114MP0003879_abnormal_hair_cell0.87023089
115MP0002638_abnormal_pupillary_reflex0.86235380
116MP0003283_abnormal_digestive_organ0.85441985
117MP0005253_abnormal_eye_physiology0.84100630
118MP0001286_abnormal_eye_development0.83234293
119MP0003045_fibrosis0.83105996
120MP0001293_anophthalmia0.82615178
121MP0001502_abnormal_circadian_rhythm0.82270705
122MP0003698_abnormal_male_reproductive0.78470535
123MP0002084_abnormal_developmental_patter0.78404348
124MP0005248_abnormal_Harderian_gland0.78027527
125MP0002234_abnormal_pharynx_morphology0.76541203
126MP0000631_abnormal_neuroendocrine_gland0.76252691
127MP0002210_abnormal_sex_determination0.75882414
128MP0010678_abnormal_skin_adnexa0.74398958
129MP0000747_muscle_weakness0.74295375
130MP0009703_decreased_birth_body0.71465342
131MP0006035_abnormal_mitochondrial_morpho0.71199473
132MP0004085_abnormal_heartbeat0.69668646
133MP0001915_intracranial_hemorrhage0.69268912
134MP0000013_abnormal_adipose_tissue0.69032779
135MP0005394_taste/olfaction_phenotype0.68653914
136MP0005499_abnormal_olfactory_system0.68653914
137MP0003861_abnormal_nervous_system0.68505085
138MP0000653_abnormal_sex_gland0.68267670
139MP0002069_abnormal_eating/drinking_beha0.68101335
140MP0001943_abnormal_respiration0.68028517
141MP0000762_abnormal_tongue_morphology0.67616662
142MP0005410_abnormal_fertilization0.67058317
143MP0008874_decreased_physiological_sensi0.64143172
144MP0000751_myopathy0.64016401
145MP0004134_abnormal_chest_morphology0.63699631
146MP0001348_abnormal_lacrimal_gland0.62846079
147MP0000003_abnormal_adipose_tissue0.61941744
148MP0001986_abnormal_taste_sensitivity0.60311809
149MP0003172_abnormal_lysosome_physiology0.58738581
150MP0008961_abnormal_basal_metabolism0.56152949
151MP0002090_abnormal_vision0.55410497
152MP0010769_abnormal_survival0.54162847
153MP0004484_altered_response_of0.54085280
154MP0010770_preweaning_lethality0.51662530
155MP0002082_postnatal_lethality0.51662530
156MP0005187_abnormal_penis_morphology0.50823113
157MP0001346_abnormal_lacrimal_gland0.50649122

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.55495158
2Myokymia (HP:0002411)5.44764681
3Focal seizures (HP:0007359)4.51943193
4Termporal pattern (HP:0011008)4.45533093
5Insidious onset (HP:0003587)4.45533093
6Action tremor (HP:0002345)4.43487821
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.26342639
8Degeneration of the lateral corticospinal tracts (HP:0002314)4.26342639
9Abnormality of the corticospinal tract (HP:0002492)4.11934420
10Supranuclear gaze palsy (HP:0000605)3.91476609
11Ankle clonus (HP:0011448)3.88001241
12Neurofibrillary tangles (HP:0002185)3.79518329
13Peripheral hypomyelination (HP:0007182)3.48964480
14Progressive cerebellar ataxia (HP:0002073)3.48173253
15Spastic gait (HP:0002064)3.42303366
16Cerebral inclusion bodies (HP:0100314)3.40120670
17Dysmetria (HP:0001310)3.38133292
18Pancreatic islet-cell hyperplasia (HP:0004510)3.37689516
19Epileptic encephalopathy (HP:0200134)3.31767150
20Visual hallucinations (HP:0002367)3.31381966
21Urinary urgency (HP:0000012)3.31145114
22Urinary bladder sphincter dysfunction (HP:0002839)3.29009305
23Hypoglycemic seizures (HP:0002173)3.28607204
24Hyperinsulinemic hypoglycemia (HP:0000825)3.16249901
25Enlarged penis (HP:0000040)3.14127650
26Atonic seizures (HP:0010819)3.09862022
27Febrile seizures (HP:0002373)3.08744084
28Truncal ataxia (HP:0002078)3.04466641
29Impaired vibration sensation in the lower limbs (HP:0002166)2.99961605
30Intention tremor (HP:0002080)2.99527737
31Onion bulb formation (HP:0003383)2.97238908
32Scanning speech (HP:0002168)2.94869914
33Papillary thyroid carcinoma (HP:0002895)2.89919849
34Generalized tonic-clonic seizures (HP:0002069)2.85501529
35Gaze-evoked nystagmus (HP:0000640)2.85340066
36Hyperkalemia (HP:0002153)2.85118693
37Broad-based gait (HP:0002136)2.84530264
38Absence seizures (HP:0002121)2.83252449
39Dialeptic seizures (HP:0011146)2.80550695
40Dysdiadochokinesis (HP:0002075)2.78790267
41Volvulus (HP:0002580)2.76548561
42Hypoglycemic coma (HP:0001325)2.74749589
43Lower limb muscle weakness (HP:0007340)2.69151639
44Oligodactyly (hands) (HP:0001180)2.67744780
45Pheochromocytoma (HP:0002666)2.65379311
46Long foot (HP:0001833)2.62221524
47Intestinal atresia (HP:0011100)2.57108754
48Abnormality of the labia minora (HP:0012880)2.52150131
49Excessive salivation (HP:0003781)2.48974008
50Drooling (HP:0002307)2.48974008
51Bifid tongue (HP:0010297)2.47640274
52Depression (HP:0000716)2.46318447
53Megalencephaly (HP:0001355)2.43664750
54Papilledema (HP:0001085)2.42875510
55Ulnar claw (HP:0001178)2.41383282
56Hammertoe (HP:0001765)2.40535086
57Cupped ear (HP:0000378)2.39457261
58Aqueductal stenosis (HP:0002410)2.39326674
59Genetic anticipation (HP:0003743)2.36879818
60Poor eye contact (HP:0000817)2.36099676
61Segmental peripheral demyelination/remyelination (HP:0003481)2.35801467
62Postural instability (HP:0002172)2.34432742
63Ectopic kidney (HP:0000086)2.34408571
64Abnormality of chromosome stability (HP:0003220)2.34302410
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.33051697
66Decreased motor nerve conduction velocity (HP:0003431)2.29674530
67Macroorchidism (HP:0000053)2.28610856
68Clonus (HP:0002169)2.28238294
69Fair hair (HP:0002286)2.27942719
70Meckel diverticulum (HP:0002245)2.27618771
71Colon cancer (HP:0003003)2.23831925
72Abnormality of the astrocytes (HP:0100707)2.23682201
73Astrocytoma (HP:0009592)2.23682201
74Abnormality of the ileum (HP:0001549)2.23640135
75Impaired smooth pursuit (HP:0007772)2.22427292
76Labial hypoplasia (HP:0000066)2.19902346
77Increased circulating renin level (HP:0000848)2.19431785
78Ependymoma (HP:0002888)2.18788040
79Mutism (HP:0002300)2.17618745
80Decreased circulating renin level (HP:0003351)2.16218848
81Abnormal auditory evoked potentials (HP:0006958)2.15824675
82Neuroendocrine neoplasm (HP:0100634)2.14758479
83Retinal dysplasia (HP:0007973)2.14674713
84Anxiety (HP:0000739)2.14635779
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13472068
86Abnormal social behavior (HP:0012433)2.12622358
87Impaired social interactions (HP:0000735)2.12622358
88Diplopia (HP:0000651)2.12333998
89Abnormality of binocular vision (HP:0011514)2.12333998
90Hemiparesis (HP:0001269)2.12241249
91Hypoplastic female external genitalia (HP:0012815)2.09815142
92Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.09661748
93Chromsome breakage (HP:0040012)2.09042031
94Foot dorsiflexor weakness (HP:0009027)2.08547116
95Neuronal loss in central nervous system (HP:0002529)2.08538340
96Thickened helices (HP:0000391)2.08171951
97Symptomatic seizures (HP:0011145)2.06718247
98Absent speech (HP:0001344)2.05758674
99Slow saccadic eye movements (HP:0000514)2.05147067
100Widely spaced teeth (HP:0000687)2.04003349
101Hypoplastic labia majora (HP:0000059)2.02845146
102Type II lissencephaly (HP:0007260)2.00437933
103Postural tremor (HP:0002174)1.97179217
104Blue irides (HP:0000635)1.96648480
105Impaired vibratory sensation (HP:0002495)1.96390591
106Abnormality of endocrine pancreas physiology (HP:0012093)1.95741366
107Abnormality of the pancreatic islet cells (HP:0006476)1.95741366
108Short chin (HP:0000331)1.94797682
109Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94326140
110Abnormality of saccadic eye movements (HP:0000570)1.93840777
111Abnormality of the foot musculature (HP:0001436)1.93770287
112Abnormal eating behavior (HP:0100738)1.93120416
113Thick nail (HP:0001805)1.92320603
114Bundle branch block (HP:0011710)1.91297964
115Abnormality of the preputium (HP:0100587)1.90943802
116Renal hypoplasia (HP:0000089)1.90629278
117Gait ataxia (HP:0002066)1.89759113
118Thyroid carcinoma (HP:0002890)1.89454360
119Aplasia involving bones of the upper limbs (HP:0009823)1.89415634
120Aplasia of the phalanges of the hand (HP:0009802)1.89415634
121Aplasia involving bones of the extremities (HP:0009825)1.89415634
122Morphological abnormality of the pyramidal tract (HP:0002062)1.89100521
123Sensory axonal neuropathy (HP:0003390)1.87454571
124Abnormality of ocular smooth pursuit (HP:0000617)1.87083636
125Tubulointerstitial nephritis (HP:0001970)1.86304148
126Distal sensory impairment (HP:0002936)1.86239378
127Gastrointestinal atresia (HP:0002589)1.85951019
128Insomnia (HP:0100785)1.85945519
129Progressive inability to walk (HP:0002505)1.85571509
130Hypoplastic pelvis (HP:0008839)1.85154021
131Lissencephaly (HP:0001339)1.84834304
132Hyperventilation (HP:0002883)1.83663250
133Lower limb amyotrophy (HP:0007210)1.82485859
134Clumsiness (HP:0002312)1.82432869
135Epileptiform EEG discharges (HP:0011182)1.82284232
136Congenital, generalized hypertrichosis (HP:0004540)1.81973054
137Bowel incontinence (HP:0002607)1.81281028
138Amblyopia (HP:0000646)1.81093108
139Congenital malformation of the right heart (HP:0011723)1.81006573
140Double outlet right ventricle (HP:0001719)1.81006573
141Bradykinesia (HP:0002067)1.80853105
142Stereotypic behavior (HP:0000733)1.80612145
143Clitoromegaly (HP:0000057)1.80141268
144Biliary tract neoplasm (HP:0100574)1.79981433
145Glioma (HP:0009733)1.79956632
146Spastic tetraparesis (HP:0001285)1.79851473
147Abnormality of salivation (HP:0100755)1.79479615
148Inappropriate behavior (HP:0000719)1.79192143
149EEG with generalized epileptiform discharges (HP:0011198)1.78883964
150Dysmetric saccades (HP:0000641)1.78569079
151Abnormality of the labia majora (HP:0012881)1.78073767
152Abnormal lung lobation (HP:0002101)1.77849807
153Cerebral hypomyelination (HP:0006808)1.75798171
154Rapidly progressive (HP:0003678)1.75140494
155Hypsarrhythmia (HP:0002521)1.74715112
156Abnormality of the renal cortex (HP:0011035)1.71406385
157Optic nerve hypoplasia (HP:0000609)1.69566440
158Esophageal atresia (HP:0002032)1.69182592
159Hyperactive renin-angiotensin system (HP:0000841)1.68955944
160Protruding tongue (HP:0010808)1.67853995
161Small hand (HP:0200055)1.67271183
162Abnormality of the duodenum (HP:0002246)1.65012779
163Absent eyebrow (HP:0002223)1.63555954
164Clubbing of toes (HP:0100760)1.63475320
165Exotropia (HP:0000577)1.62448686
166Anophthalmia (HP:0000528)1.61216513
167Horizontal nystagmus (HP:0000666)1.61073593
168Abnormality of the labia (HP:0000058)1.60386757
169Absent radius (HP:0003974)1.60199105
170Pancreatic cysts (HP:0001737)1.59100351
171Generalized hypopigmentation of hair (HP:0011358)1.58504380
172Methylmalonic acidemia (HP:0002912)1.58383620
173True hermaphroditism (HP:0010459)1.57656328
174Embryonal renal neoplasm (HP:0011794)1.57510372
175Intellectual disability, moderate (HP:0002342)1.57332384
176Oligodactyly (HP:0012165)1.56979594
177Gastroesophageal reflux (HP:0002020)1.55565347
178Ketoacidosis (HP:0001993)1.53945341
179Abnormality of the renal medulla (HP:0100957)1.53071958
180Duodenal stenosis (HP:0100867)1.52621954
181Small intestinal stenosis (HP:0012848)1.52621954
182Genital tract atresia (HP:0001827)1.51209498
183Hyperaldosteronism (HP:0000859)1.50896560
184Cutaneous finger syndactyly (HP:0010554)1.48168635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.65836388
2NTRK33.84807986
3FRK3.21993506
4MAP3K92.95572748
5BMPR1B2.81599532
6MARK12.74398207
7MAP3K42.74359325
8EPHA42.64265379
9PRKD32.59702048
10STK392.50967460
11PAK62.43096038
12NTRK12.42369963
13TNIK2.31418364
14MINK12.25754833
15TRIM282.22095168
16PNCK2.18237749
17WNK32.17169857
18NTRK21.98959966
19ACVR1B1.96827487
20KSR21.94728595
21MAPKAPK51.90140109
22MKNK21.90126834
23DAPK21.89425319
24SGK2231.78365855
25SGK4941.78365855
26MAP2K71.75542247
27WNK11.74430169
28UHMK11.72582003
29AKT31.69441183
30MAP3K21.69008456
31OXSR11.66109602
32MAP4K21.66098174
33FGFR21.59682679
34EIF2AK31.56717291
35TIE11.54663408
36CDK51.49689201
37CAMK1G1.48508337
38MAP2K41.42097614
39CAMKK11.37183936
40CASK1.33492800
41TGFBR11.33383516
42TYRO31.32033974
43PLK31.31743127
44PKN11.27261405
45PLK21.24749074
46MAPK131.24634887
47EIF2AK11.18619683
48RIPK41.17138554
49YES11.14798195
50ERBB31.14137815
51IRAK21.12443889
52STK38L1.10893551
53NUAK11.09863379
54RET1.09761222
55SCYL21.07636267
56GRK51.04459879
57DYRK21.04199041
58PRKCH1.03256459
59MARK21.01404002
60CAMK2B1.00633404
61PHKG20.98551640
62PHKG10.98551640
63SIK20.97660075
64CSNK1G20.95421098
65EPHB10.95101581
66BRSK20.94686926
67CAMK2A0.93843366
68KSR10.93360737
69STK110.92965726
70WNK40.92711827
71MKNK10.90265968
72STK380.90181694
73MST40.89438767
74LATS20.88807692
75WEE10.88506941
76PRPF4B0.88308755
77TAF10.87898933
78SGK10.87735410
79BCR0.86632296
80STK30.86352264
81ALK0.85815608
82SGK30.84006565
83CDK140.82943890
84ROCK20.81811392
85SGK20.80879447
86TTK0.80728681
87EPHB20.80102251
88PAK30.80012822
89LATS10.79856112
90CDK150.79069177
91CAMKK20.78245250
92PRKCG0.78141096
93IRAK10.77690571
94CDK180.77595569
95CDK190.76914724
96CSNK1A1L0.74257423
97CSNK1G10.74156167
98MAPK100.72853727
99PLK40.72030823
100FGFR10.72005113
101TSSK60.71672938
102MAP3K120.69822687
103PDPK10.69787918
104CAMK10.69591255
105CAMK2D0.69398760
106LIMK10.69183014
107DMPK0.68676527
108ROCK10.67826269
109MET0.67094185
110FES0.66232929
111ATM0.65140258
112PDK10.64733001
113NLK0.64246744
114CDK11A0.64016273
115ZAK0.63922113
116CAMK1D0.63875370
117PRKCE0.62624997
118TAOK10.60989635
119NEK60.60269794
120PLK10.58768197
121FGR0.58734977
122PRKD10.57235977
123RPS6KA30.56368278
124GRK10.56234322
125MUSK0.56197444
126CDC70.55596201
127VRK10.54288343
128MELK0.54061178
129CSNK1E0.53935739
130CSNK1G30.53504257
131MAP2K60.52986221
132FYN0.52210987
133MAP3K10.52047689
134FER0.49653233
135LMTK20.48738565
136DYRK1A0.47979283
137CSNK1D0.47549621
138CDC42BPA0.47052485
139CAMK2G0.46837893
140DAPK10.46733831
141PINK10.46643549
142CDK80.45434559
143TNK20.44441313
144PTK20.44295192
145PTK2B0.42269604
146OBSCN0.42181922
147PDGFRB0.40875874
148HIPK20.40689473
149ARAF0.40001028
150BMPR20.39835223
151BRAF0.38291630
152ERBB40.37304265
153RPS6KB10.36766326
154CDK30.36362079
155CHEK10.36209455
156BRSK10.35501516
157BUB10.34961259
158IGF1R0.34510148

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.74696135
2Synaptic vesicle cycle_Homo sapiens_hsa047212.55121602
3GABAergic synapse_Homo sapiens_hsa047272.40304047
4Glutamatergic synapse_Homo sapiens_hsa047242.37760671
5Long-term potentiation_Homo sapiens_hsa047202.32263891
6Circadian entrainment_Homo sapiens_hsa047132.30785178
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29649362
8Olfactory transduction_Homo sapiens_hsa047402.23053783
9Morphine addiction_Homo sapiens_hsa050322.19364272
10Non-homologous end-joining_Homo sapiens_hsa034502.05939139
11Dopaminergic synapse_Homo sapiens_hsa047282.02711889
12Propanoate metabolism_Homo sapiens_hsa006402.00931240
13Amphetamine addiction_Homo sapiens_hsa050312.00249284
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95289999
15Salivary secretion_Homo sapiens_hsa049701.88594251
16Insulin secretion_Homo sapiens_hsa049111.84420548
17Cholinergic synapse_Homo sapiens_hsa047251.82509319
18Nitrogen metabolism_Homo sapiens_hsa009101.79426402
19Long-term depression_Homo sapiens_hsa047301.74774472
20Gastric acid secretion_Homo sapiens_hsa049711.74657127
21Serotonergic synapse_Homo sapiens_hsa047261.66759142
22Cocaine addiction_Homo sapiens_hsa050301.63260283
23Basal transcription factors_Homo sapiens_hsa030221.59970670
24Taste transduction_Homo sapiens_hsa047421.59501752
25Renin secretion_Homo sapiens_hsa049241.58400692
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58347654
27Adherens junction_Homo sapiens_hsa045201.56890627
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56528528
29Fanconi anemia pathway_Homo sapiens_hsa034601.56130581
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51188945
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48168540
32Circadian rhythm_Homo sapiens_hsa047101.42550342
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41180684
34Protein export_Homo sapiens_hsa030601.39803175
35Oxytocin signaling pathway_Homo sapiens_hsa049211.39215160
36Axon guidance_Homo sapiens_hsa043601.37873774
37Dorso-ventral axis formation_Homo sapiens_hsa043201.37513150
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37001117
39GnRH signaling pathway_Homo sapiens_hsa049121.36998649
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34074741
41Type II diabetes mellitus_Homo sapiens_hsa049301.33590037
42Hippo signaling pathway_Homo sapiens_hsa043901.30399296
43Homologous recombination_Homo sapiens_hsa034401.28350253
44Gap junction_Homo sapiens_hsa045401.26782770
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25569154
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24446572
47Butanoate metabolism_Homo sapiens_hsa006501.23415125
48Vitamin B6 metabolism_Homo sapiens_hsa007501.22679680
49Calcium signaling pathway_Homo sapiens_hsa040201.22441540
50ErbB signaling pathway_Homo sapiens_hsa040121.21914304
51Estrogen signaling pathway_Homo sapiens_hsa049151.18396146
52cAMP signaling pathway_Homo sapiens_hsa040241.17657443
53Glioma_Homo sapiens_hsa052141.17503829
54TGF-beta signaling pathway_Homo sapiens_hsa043501.15314484
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15170898
56Selenocompound metabolism_Homo sapiens_hsa004501.14233380
57Lysine degradation_Homo sapiens_hsa003101.12756575
58Mismatch repair_Homo sapiens_hsa034301.06628557
59RNA degradation_Homo sapiens_hsa030181.02609813
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01956876
61Renal cell carcinoma_Homo sapiens_hsa052111.01531891
62Phospholipase D signaling pathway_Homo sapiens_hsa040721.00324172
63Melanogenesis_Homo sapiens_hsa049161.00242550
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.98210000
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93637894
66beta-Alanine metabolism_Homo sapiens_hsa004100.93422550
67Fatty acid metabolism_Homo sapiens_hsa012120.92768968
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.90937315
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90627611
70Pancreatic secretion_Homo sapiens_hsa049720.88624820
71Ether lipid metabolism_Homo sapiens_hsa005650.88573977
72Basal cell carcinoma_Homo sapiens_hsa052170.88134011
73Phototransduction_Homo sapiens_hsa047440.87762276
74Collecting duct acid secretion_Homo sapiens_hsa049660.87490031
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87046239
76MAPK signaling pathway_Homo sapiens_hsa040100.86322668
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84465194
78Choline metabolism in cancer_Homo sapiens_hsa052310.83637087
79Ras signaling pathway_Homo sapiens_hsa040140.83385029
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.82753397
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78712140
82Oocyte meiosis_Homo sapiens_hsa041140.77552326
83Fatty acid degradation_Homo sapiens_hsa000710.77100695
84Endocytosis_Homo sapiens_hsa041440.76160362
85Thyroid hormone synthesis_Homo sapiens_hsa049180.75861731
86Cell cycle_Homo sapiens_hsa041100.75412290
87Fatty acid biosynthesis_Homo sapiens_hsa000610.75213240
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74063469
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.73342804
90Arginine and proline metabolism_Homo sapiens_hsa003300.72650089
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71665676
92Inositol phosphate metabolism_Homo sapiens_hsa005620.71616724
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70947444
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70727847
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.70331016
96Nucleotide excision repair_Homo sapiens_hsa034200.70035900
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69553665
98Dilated cardiomyopathy_Homo sapiens_hsa054140.69546013
99ECM-receptor interaction_Homo sapiens_hsa045120.68406662
100Alcoholism_Homo sapiens_hsa050340.68384691
101Steroid biosynthesis_Homo sapiens_hsa001000.68257359
102VEGF signaling pathway_Homo sapiens_hsa043700.68152761
103Rap1 signaling pathway_Homo sapiens_hsa040150.67286222
104Vibrio cholerae infection_Homo sapiens_hsa051100.66502221
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66429913
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66421112
107ABC transporters_Homo sapiens_hsa020100.62537880
108Tryptophan metabolism_Homo sapiens_hsa003800.61271895
109Tight junction_Homo sapiens_hsa045300.60980264
110mTOR signaling pathway_Homo sapiens_hsa041500.60947377
111RNA transport_Homo sapiens_hsa030130.60328139
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60099641
113Histidine metabolism_Homo sapiens_hsa003400.59810919
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59789628
115Type I diabetes mellitus_Homo sapiens_hsa049400.59768527
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59766088
117Regulation of autophagy_Homo sapiens_hsa041400.58119643
118Melanoma_Homo sapiens_hsa052180.57573606
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57567123
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57300476
121Wnt signaling pathway_Homo sapiens_hsa043100.57059389
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56129490
123Endometrial cancer_Homo sapiens_hsa052130.54132025
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53230659
125Ovarian steroidogenesis_Homo sapiens_hsa049130.52212294
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50875546
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50810109
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49851637
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49809068
130Non-small cell lung cancer_Homo sapiens_hsa052230.48807488
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47793398
132Cardiac muscle contraction_Homo sapiens_hsa042600.47768445
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47278328
134Chemokine signaling pathway_Homo sapiens_hsa040620.46930659
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46827913
136Hedgehog signaling pathway_Homo sapiens_hsa043400.43266853
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41700549
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40655250
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40632998
140Fatty acid elongation_Homo sapiens_hsa000620.39710871
141Prion diseases_Homo sapiens_hsa050200.39292559
142Glucagon signaling pathway_Homo sapiens_hsa049220.39278322
143Colorectal cancer_Homo sapiens_hsa052100.37927964
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37758094
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37378209
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36969762

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