USP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.19407029
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.98691967
3DNA unwinding involved in DNA replication (GO:0006268)4.93505905
4negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.93166000
5DNA strand elongation involved in DNA replication (GO:0006271)4.70073094
6COPI coating of Golgi vesicle (GO:0048205)4.60647913
7Golgi transport vesicle coating (GO:0048200)4.60647913
8DNA deamination (GO:0045006)4.55414157
9DNA strand elongation (GO:0022616)4.45144057
10DNA replication initiation (GO:0006270)4.32187835
11negative regulation of RNA splicing (GO:0033119)4.20749483
12telomere maintenance via semi-conservative replication (GO:0032201)4.15318563
13negative regulation of mRNA processing (GO:0050686)4.13683375
14peptidyl-arginine omega-N-methylation (GO:0035247)4.10206915
15spliceosomal tri-snRNP complex assembly (GO:0000244)4.04669510
16proline biosynthetic process (GO:0006561)4.02317012
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.01812972
183-UTR-mediated mRNA stabilization (GO:0070935)3.92218240
19protein insertion into membrane (GO:0051205)3.87012429
20regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.79001827
21histone arginine methylation (GO:0034969)3.73430460
22peptidyl-arginine methylation (GO:0018216)3.72488040
23peptidyl-arginine N-methylation (GO:0035246)3.72488040
24histone H2A acetylation (GO:0043968)3.70295856
25histone H4 deacetylation (GO:0070933)3.70178332
26snRNA metabolic process (GO:0016073)3.69076406
27nucleosome disassembly (GO:0006337)3.63257372
28protein-DNA complex disassembly (GO:0032986)3.63257372
29histone H4-K12 acetylation (GO:0043983)3.53703521
30GDP-mannose metabolic process (GO:0019673)3.47615336
31telomere maintenance via recombination (GO:0000722)3.46456264
32sensory perception of smell (GO:0007608)3.46453337
33negative regulation of mRNA metabolic process (GO:1903312)3.44416463
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43573925
35protein retention in ER lumen (GO:0006621)3.43545387
36snRNA processing (GO:0016180)3.42793761
37regulation of histone H3-K27 methylation (GO:0061085)3.41944601
38regulation of gamma-delta T cell differentiation (GO:0045586)3.40834712
39mitotic recombination (GO:0006312)3.39380495
40DNA damage response, signal transduction resulting in transcription (GO:0042772)3.38138153
41termination of RNA polymerase II transcription (GO:0006369)3.33100865
42histone H3 deacetylation (GO:0070932)3.32365573
43positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29378301
44positive regulation of gamma-delta T cell activation (GO:0046645)3.28240865
45RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.24388370
46mRNA splicing, via spliceosome (GO:0000398)3.24388370
47mannose metabolic process (GO:0006013)3.23639647
48telomere maintenance via telomere lengthening (GO:0010833)3.21901233
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21407718
50DNA replication checkpoint (GO:0000076)3.20719776
51dosage compensation (GO:0007549)3.19584320
52creatine metabolic process (GO:0006600)3.19119733
53negative regulation of cell size (GO:0045792)3.18731298
54histone H3-K9 demethylation (GO:0033169)3.18727370
55RNA splicing, via transesterification reactions (GO:0000375)3.18597678
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18512912
57translesion synthesis (GO:0019985)3.16625540
58modulation by virus of host process (GO:0019054)3.15799724
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15220403
60base-excision repair (GO:0006284)3.14088513
61poly(A)+ mRNA export from nucleus (GO:0016973)3.11326475
62histone H4-K5 acetylation (GO:0043981)3.11250214
63histone H4-K8 acetylation (GO:0043982)3.11250214
64thymic T cell selection (GO:0045061)3.08106935
65mRNA splice site selection (GO:0006376)3.07775526
66pre-miRNA processing (GO:0031054)3.07594794
67DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.05636279
68regulation of DNA damage checkpoint (GO:2000001)3.05624667
69somatic hypermutation of immunoglobulin genes (GO:0016446)3.05404621
70somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05404621
71regulation of response to osmotic stress (GO:0047484)3.04129214
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.03257716
73positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.02367301
74negative regulation of chromosome segregation (GO:0051985)2.99564196
75negative regulation of mitotic sister chromatid separation (GO:2000816)2.96870585
76negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96870585
77negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96870585
78negative regulation of sister chromatid segregation (GO:0033046)2.96870585
79regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96412152
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.95410171
81negative regulation of DNA-templated transcription, elongation (GO:0032785)2.95410171
82protoporphyrinogen IX metabolic process (GO:0046501)2.95252678
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93499714
84mitotic spindle assembly checkpoint (GO:0007094)2.92652913
85DNA topological change (GO:0006265)2.91904476
86mitotic chromosome condensation (GO:0007076)2.90924731
87retinoic acid receptor signaling pathway (GO:0048384)2.88917051
88base-excision repair, AP site formation (GO:0006285)2.87072372
89cellular response to interleukin-4 (GO:0071353)2.85782604
90histone H3-K9 modification (GO:0061647)2.85127568
91negative T cell selection (GO:0043383)2.83804028
92spindle assembly checkpoint (GO:0071173)2.83239194
93pentose-phosphate shunt (GO:0006098)2.82241906
94positive thymic T cell selection (GO:0045059)2.81555789
95regulation of gamma-delta T cell activation (GO:0046643)2.80885443
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80532426
97spliceosomal snRNP assembly (GO:0000387)2.79748295
98proline metabolic process (GO:0006560)2.79630786
99mismatch repair (GO:0006298)2.79592499
100maternal placenta development (GO:0001893)2.79132087
101apoptotic process involved in morphogenesis (GO:0060561)2.78177479
102pyrimidine nucleotide catabolic process (GO:0006244)2.77802929
103Peyers patch development (GO:0048541)2.72698470
104mucosal-associated lymphoid tissue development (GO:0048537)2.72698470
105regulation of telomere maintenance via telomerase (GO:0032210)2.71473880
106DNA duplex unwinding (GO:0032508)2.70556109
107DNA geometric change (GO:0032392)2.69209067
108protein localization to kinetochore (GO:0034501)2.68312740
109negative regulation of histone methylation (GO:0031061)2.67975550
110regulation of mitotic spindle organization (GO:0060236)2.67215906
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.67048155
112regulation of chromatin binding (GO:0035561)2.67003877
113regulation of defense response to virus by virus (GO:0050690)2.66610472
114postreplication repair (GO:0006301)2.66527158
115DNA replication-independent nucleosome organization (GO:0034724)2.65812933
116DNA replication-independent nucleosome assembly (GO:0006336)2.65812933
117entrainment of circadian clock by photoperiod (GO:0043153)2.65742682
118mitotic nuclear envelope disassembly (GO:0007077)2.64180490
119face development (GO:0060324)2.64128311
120response to interleukin-4 (GO:0070670)2.64114444
121response to pheromone (GO:0019236)2.63480626
122histone lysine demethylation (GO:0070076)2.63284019
123regulation of mitochondrial translation (GO:0070129)2.62846014
124histone deacetylation (GO:0016575)2.62306587
125retrograde transport, endosome to Golgi (GO:0042147)2.62089471
126histone H3 acetylation (GO:0043966)2.61991533
127histone demethylation (GO:0016577)2.61629139
128regulation of actin nucleation (GO:0051125)2.61314617
129negative regulation of necroptotic process (GO:0060546)2.60028283
130negative thymic T cell selection (GO:0045060)2.59734174
131protein demethylation (GO:0006482)2.59711297
132protein dealkylation (GO:0008214)2.59711297
133negative regulation of myotube differentiation (GO:0010832)2.59613909
134positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.59584930
135detection of bacterium (GO:0016045)2.58601619
136establishment of integrated proviral latency (GO:0075713)2.57895946
137DNA replication-dependent nucleosome assembly (GO:0006335)2.57814155
138DNA replication-dependent nucleosome organization (GO:0034723)2.57814155
139cilium or flagellum-dependent cell motility (GO:0001539)2.57500077
140stress granule assembly (GO:0034063)2.57331538
141intracellular estrogen receptor signaling pathway (GO:0030520)2.56209315
142G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.55838726
143regulation of cytokine production involved in inflammatory response (GO:1900015)2.55805217
144IMP biosynthetic process (GO:0006188)2.55636205
145spliceosomal complex assembly (GO:0000245)2.55309878
146histone H4 acetylation (GO:0043967)2.55157359
147cellular response to virus (GO:0098586)2.54920327
148regulation of chromosome segregation (GO:0051983)2.54844475
149histone H4-K16 acetylation (GO:0043984)2.54180404
150signal complex assembly (GO:0007172)2.53744510
151negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53663953
152negative regulation of cell killing (GO:0031342)2.53663953
153telomere maintenance (GO:0000723)2.53272410
154mitotic metaphase plate congression (GO:0007080)2.53148862
155protoporphyrinogen IX biosynthetic process (GO:0006782)2.53064403
156negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.52426253
157telomere organization (GO:0032200)2.51969547
158peptidyl-arginine modification (GO:0018195)2.50456599
159negative regulation of microtubule polymerization (GO:0031115)2.50304820
160protein localization to chromosome, centromeric region (GO:0071459)2.48960848
161maintenance of protein localization in organelle (GO:0072595)2.48539689
162pyrimidine nucleobase catabolic process (GO:0006208)2.48215790
163RNA export from nucleus (GO:0006405)2.48111726
164negative regulation of telomere maintenance (GO:0032205)2.46810024
165membrane disassembly (GO:0030397)2.46587623
166nuclear envelope disassembly (GO:0051081)2.46587623
167regulation of helicase activity (GO:0051095)2.46326325
168RNA splicing (GO:0008380)2.46203821
169positive regulation of DNA-dependent DNA replication (GO:2000105)2.45958915
170virion assembly (GO:0019068)2.45933716
171regulation of ARF GTPase activity (GO:0032312)2.45924431
172establishment of mitochondrion localization (GO:0051654)2.45897035
173axonemal dynein complex assembly (GO:0070286)2.45664996
174maturation of SSU-rRNA (GO:0030490)2.45223788
175RNA stabilization (GO:0043489)2.45171149
176mRNA stabilization (GO:0048255)2.45171149
177kinetochore assembly (GO:0051382)2.44469807
178positive regulation of granulocyte differentiation (GO:0030854)2.43924186
179negative regulation of gene expression, epigenetic (GO:0045814)2.43813704
180mitotic spindle checkpoint (GO:0071174)2.43433989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.53917446
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.37719504
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24631183
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.15480538
5MYC_22102868_ChIP-Seq_BL_Human3.02393051
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81308907
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70229848
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65170508
9* CIITA_25753668_ChIP-Seq_RAJI_Human2.62511125
10VDR_21846776_ChIP-Seq_THP-1_Human2.34016368
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32736504
12* XRN2_22483619_ChIP-Seq_HELA_Human2.32523447
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32419560
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.30017092
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.21177330
16CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.19705956
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14888526
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12338623
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06484546
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.03071293
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99494703
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99157924
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95347906
24MAF_26560356_Chip-Seq_TH2_Human1.91714226
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89673777
26RACK7_27058665_Chip-Seq_MCF-7_Human1.87518408
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84039442
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.83369765
29EZH2_22144423_ChIP-Seq_EOC_Human1.80056962
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.78321630
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76734927
32GABP_19822575_ChIP-Seq_HepG2_Human1.75209364
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72049736
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.70372627
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.69088784
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68452700
37ZNF263_19887448_ChIP-Seq_K562_Human1.63701085
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.63403294
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.63353082
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61930821
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60909151
42TTF2_22483619_ChIP-Seq_HELA_Human1.60770594
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57953486
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56794037
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56425329
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52417517
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51347061
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49954631
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49480528
50FOXP3_21729870_ChIP-Seq_TREG_Human1.49157788
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48823326
52CREB1_26743006_Chip-Seq_LNCaP_Human1.45484496
53SMC4_20622854_ChIP-Seq_HELA_Human1.45149363
54* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43255938
55NCOR1_26117541_ChIP-Seq_K562_Human1.41934209
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41388596
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.40592780
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40104329
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39829278
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38220448
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37469597
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.36986076
63BCL6_27268052_Chip-Seq_Bcells_Human1.36791514
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36612726
65* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36406847
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36368428
67KDM2B_26808549_Chip-Seq_K562_Human1.36189599
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35371249
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34457590
70VDR_24763502_ChIP-Seq_THP-1_Human1.33602755
71* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32563815
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31859569
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30274876
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30101449
75TCF7_22412390_ChIP-Seq_EML_Mouse1.29634780
76SCL_19346495_ChIP-Seq_HPC-7_Human1.29589943
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29559399
78BCOR_27268052_Chip-Seq_Bcells_Human1.29238363
79* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28015002
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.26507685
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25717967
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24168230
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23843387
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23746640
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23643441
86PHF8_20622854_ChIP-Seq_HELA_Human1.22743090
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.21511576
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20814719
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20553182
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20227860
91LXR_22292898_ChIP-Seq_THP-1_Human1.19927302
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19521617
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19361469
94* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19361163
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19317827
96CTCF_21964334_Chip-Seq_Bcells_Human1.19173673
97* VDR_23849224_ChIP-Seq_CD4+_Human1.17602471
98RARB_24833708_ChIP-Seq_LIVER_Mouse1.17204685
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17202856
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17188086
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15869786
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15863169
103FOXP1_21924763_ChIP-Seq_HESCs_Human1.15717439
104* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15210297
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14877728
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.13973314
107UTX_26944678_Chip-Seq_JUKART_Human1.13959617
108ETS1_21867929_ChIP-Seq_TH2_Mouse1.13570610
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13027816
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12638815
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12475610
112RARA_24833708_ChIP-Seq_LIVER_Mouse1.12356875
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.12305806
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.12161861
115* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12160004
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11877164
117CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11816913
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11641158
119KDM2B_26808549_Chip-Seq_DND41_Human1.11313892
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11278694
121* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10870540
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.10572381
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10492934
124CTCF_27219007_Chip-Seq_Bcells_Human1.10480268
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10464226
126KDM5A_27292631_Chip-Seq_BREAST_Human1.10425108
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10246331
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.09996702
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08879269
130AR_21909140_ChIP-Seq_LNCAP_Human1.08347169
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08011083
132DCP1A_22483619_ChIP-Seq_HELA_Human1.06954270
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05800191
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04047775
135* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03909255
136SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03693862
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02834469
138SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02340810
139* TET1_21451524_ChIP-Seq_MESCs_Mouse1.02203780
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01744889
141MAF_26560356_Chip-Seq_TH1_Human1.01715127
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00527167
143SRF_21415370_ChIP-Seq_HL-1_Mouse1.00272223
144ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00261772
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98190434
146* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98122126
147RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97507934
148TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96770749
149P68_20966046_ChIP-Seq_HELA_Human0.95485292
150CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95433442
151* SA1_27219007_Chip-Seq_ERYTHROID_Human0.94921796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.80932404
2MP0002653_abnormal_ependyma_morphology3.66983560
3MP0010094_abnormal_chromosome_stability3.35240055
4MP0003693_abnormal_embryo_hatching3.33032715
5MP0008057_abnormal_DNA_replication3.30621364
6MP0001984_abnormal_olfaction3.28991416
7MP0006292_abnormal_olfactory_placode3.06528361
8MP0004133_heterotaxia3.01738295
9MP0003111_abnormal_nucleus_morphology2.99273275
10MP0008058_abnormal_DNA_repair2.89783658
11MP0008007_abnormal_cellular_replicative2.74607021
12MP0003077_abnormal_cell_cycle2.71630872
13MP0005451_abnormal_body_composition2.67500053
14MP0005083_abnormal_biliary_tract2.59491357
15MP0008260_abnormal_autophagy2.58967326
16MP0000537_abnormal_urethra_morphology2.58711730
17MP0002132_abnormal_respiratory_system2.58329775
18MP0002822_catalepsy2.27174476
19MP0004957_abnormal_blastocyst_morpholog2.24164456
20MP0002102_abnormal_ear_morphology2.23573095
21MP0002396_abnormal_hematopoietic_system2.18924468
22MP0000566_synostosis2.13114805
23MP0003656_abnormal_erythrocyte_physiolo2.03176479
24MP0001346_abnormal_lacrimal_gland1.88984349
25MP0005058_abnormal_lysosome_morphology1.84928919
26MP0003172_abnormal_lysosome_physiology1.78026430
27MP0002249_abnormal_larynx_morphology1.76533263
28MP0004859_abnormal_synaptic_plasticity1.75493650
29MP0000049_abnormal_middle_ear1.73307681
30MP0001293_anophthalmia1.72567383
31MP0000350_abnormal_cell_proliferation1.70757209
32MP0008789_abnormal_olfactory_epithelium1.66378140
33MP0008932_abnormal_embryonic_tissue1.63848827
34MP0002085_abnormal_embryonic_tissue1.61537368
35MP0001529_abnormal_vocalization1.60853059
36MP0001849_ear_inflammation1.58532632
37MP0000534_abnormal_ureter_morphology1.57700540
38MP0001730_embryonic_growth_arrest1.57083556
39MP0005394_taste/olfaction_phenotype1.56050827
40MP0005499_abnormal_olfactory_system1.56050827
41MP0003890_abnormal_embryonic-extraembry1.55945678
42MP0004185_abnormal_adipocyte_glucose1.55431009
43MP0003122_maternal_imprinting1.53239264
44MP0003436_decreased_susceptibility_to1.51249215
45MP0002084_abnormal_developmental_patter1.47902411
46MP0000751_myopathy1.45106449
47MP0000631_abnormal_neuroendocrine_gland1.43904672
48MP0004381_abnormal_hair_follicle1.40961367
49MP0003121_genomic_imprinting1.40211641
50MP0000490_abnormal_crypts_of1.38462905
51MP0003861_abnormal_nervous_system1.36821276
52MP0003763_abnormal_thymus_physiology1.36407461
53MP0002638_abnormal_pupillary_reflex1.35407027
54MP0001697_abnormal_embryo_size1.32760432
55MP0003786_premature_aging1.32264219
56MP0005423_abnormal_somatic_nervous1.29322575
57MP0003191_abnormal_cellular_cholesterol1.28459444
58MP0005171_absent_coat_pigmentation1.26729801
59MP0003123_paternal_imprinting1.25680878
60MP0004233_abnormal_muscle_weight1.23817526
61MP0000313_abnormal_cell_death1.22867878
62MP0004858_abnormal_nervous_system1.18148485
63MP0002080_prenatal_lethality1.17060727
64MP0001502_abnormal_circadian_rhythm1.16377135
65MP0003567_abnormal_fetal_cardiomyocyte1.16334305
66MP0002932_abnormal_joint_morphology1.16245849
67MP0003942_abnormal_urinary_system1.15843199
68MP0001672_abnormal_embryogenesis/_devel1.14339889
69MP0005380_embryogenesis_phenotype1.14339889
70MP0000778_abnormal_nervous_system1.13196559
71MP0000703_abnormal_thymus_morphology1.12822894
72MP0003283_abnormal_digestive_organ1.12034960
73MP0003329_amyloid_beta_deposits1.11328041
74MP0002210_abnormal_sex_determination1.10894371
75MP0008995_early_reproductive_senescence1.10006837
76MP0005666_abnormal_adipose_tissue1.09792371
77MP0002751_abnormal_autonomic_nervous1.07751804
78MP0000678_abnormal_parathyroid_gland1.07515463
79MP0005623_abnormal_meninges_morphology1.07489600
80MP0003115_abnormal_respiratory_system1.06988506
81MP0000003_abnormal_adipose_tissue1.05265589
82MP0002009_preneoplasia1.04540357
83MP0004808_abnormal_hematopoietic_stem1.04195503
84MP0002092_abnormal_eye_morphology1.03238752
85MP0002234_abnormal_pharynx_morphology1.02868774
86MP0003943_abnormal_hepatobiliary_system1.02719914
87MP0000733_abnormal_muscle_development1.02570066
88MP0009278_abnormal_bone_marrow1.01905293
89MP0003303_peritoneal_inflammation1.01349144
90MP0003984_embryonic_growth_retardation1.00670920
91MP0002184_abnormal_innervation1.00515138
92MP0002429_abnormal_blood_cell0.99711531
93MP0005501_abnormal_skin_physiology0.98906814
94MP0001145_abnormal_male_reproductive0.98396931
95MP0000716_abnormal_immune_system0.98239547
96MP0005621_abnormal_cell_physiology0.97793838
97MP0002019_abnormal_tumor_incidence0.96646435
98MP0002398_abnormal_bone_marrow0.96555509
99MP0003119_abnormal_digestive_system0.96258454
100MP0002088_abnormal_embryonic_growth/wei0.96153289
101MP0001270_distended_abdomen0.95579570
102MP0001286_abnormal_eye_development0.93649856
103MP0008569_lethality_at_weaning0.91933470
104MP0001188_hyperpigmentation0.91857644
105MP0003315_abnormal_perineum_morphology0.91582752
106MP0005025_abnormal_response_to0.91177904
107MP0006072_abnormal_retinal_apoptosis0.91096282
108MP0002420_abnormal_adaptive_immunity0.91048438
109MP0002938_white_spotting0.91024805
110MP0002089_abnormal_postnatal_growth/wei0.90429968
111MP0001929_abnormal_gametogenesis0.90417741
112MP0005397_hematopoietic_system_phenotyp0.89934416
113MP0001545_abnormal_hematopoietic_system0.89934416
114MP0001819_abnormal_immune_cell0.89933380
115MP0004197_abnormal_fetal_growth/weight/0.89646889
116MP0002152_abnormal_brain_morphology0.89234085
117MP0008961_abnormal_basal_metabolism0.89060304
118MP0000653_abnormal_sex_gland0.88357463
119MP0005646_abnormal_pituitary_gland0.88312144
120MP0003136_yellow_coat_color0.88080580
121MP0000358_abnormal_cell_content/0.87670527
122MP0002116_abnormal_craniofacial_bone0.87652663
123MP0000759_abnormal_skeletal_muscle0.87626615
124MP0002697_abnormal_eye_size0.87624981
125MP0000681_abnormal_thyroid_gland0.87288008
126MP0000428_abnormal_craniofacial_morphol0.87281055
127MP0005375_adipose_tissue_phenotype0.87041730
128MP0005670_abnormal_white_adipose0.85270350
129MP0006036_abnormal_mitochondrial_physio0.84193388
130MP0000858_altered_metastatic_potential0.82998390
131MP0003938_abnormal_ear_development0.82646697
132MP0005409_darkened_coat_color0.81889667
133MP0000689_abnormal_spleen_morphology0.81437169
134MP0001119_abnormal_female_reproductive0.80403066
135MP0006035_abnormal_mitochondrial_morpho0.79779170
136MP0005391_vision/eye_phenotype0.79583155
137MP0008770_decreased_survivor_rate0.79563400
138MP0002160_abnormal_reproductive_system0.79099212
139MP0002405_respiratory_system_inflammati0.78511718
140MP0010386_abnormal_urinary_bladder0.77218352
141MP0005384_cellular_phenotype0.76878077
142MP0005075_abnormal_melanosome_morpholog0.76710518
143MP0002722_abnormal_immune_system0.76567971
144MP0005257_abnormal_intraocular_pressure0.75513579
145MP0005076_abnormal_cell_differentiation0.75493771
146MP0005220_abnormal_exocrine_pancreas0.75001911
147MP0009672_abnormal_birth_weight0.74715012
148MP0003137_abnormal_impulse_conducting0.73665412
149MP0002970_abnormal_white_adipose0.73454180
150MP0003866_abnormal_defecation0.73046658
151MP0003948_abnormal_gas_homeostasis0.72352527
152MP0002086_abnormal_extraembryonic_tissu0.72131192
153MP0008877_abnormal_DNA_methylation0.70623474
154MP0009931_abnormal_skin_appearance0.70440499
155MP0009333_abnormal_splenocyte_physiolog0.69670605
156MP0003705_abnormal_hypodermis_morpholog0.69054752
157MP0002723_abnormal_immune_serum0.68744555
158MP0002127_abnormal_cardiovascular_syste0.68025685
159MP0001348_abnormal_lacrimal_gland0.67828235

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)4.22216082
2Abnormal gallbladder physiology (HP:0012438)4.22216082
3Ependymoma (HP:0002888)4.15024869
4Myopathic facies (HP:0002058)4.02347340
5Male infertility (HP:0003251)3.59906473
6Selective tooth agenesis (HP:0001592)3.52880822
7Metaphyseal cupping (HP:0003021)3.50656977
8Ragged-red muscle fibers (HP:0003200)3.49182321
9Aplastic anemia (HP:0001915)3.42821305
10Atelectasis (HP:0100750)3.34866230
11Hyperacusis (HP:0010780)3.28299232
12Obstructive sleep apnea (HP:0002870)3.23437343
13Severe visual impairment (HP:0001141)3.14365567
14Microvesicular hepatic steatosis (HP:0001414)3.08315246
15Patellar aplasia (HP:0006443)3.02161254
16Annular pancreas (HP:0001734)2.96901248
17Cholelithiasis (HP:0001081)2.95494925
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.94533844
19Centrally nucleated skeletal muscle fibers (HP:0003687)2.93463312
20Reticulocytosis (HP:0001923)2.91922135
21Seborrheic dermatitis (HP:0001051)2.90100857
22Anal stenosis (HP:0002025)2.89949776
23Medulloblastoma (HP:0002885)2.83301499
24Acute lymphatic leukemia (HP:0006721)2.83096531
25Abnormal number of incisors (HP:0011064)2.79497468
26Ankle clonus (HP:0011448)2.77480790
27Birth length less than 3rd percentile (HP:0003561)2.77266497
28Aplasia/Hypoplasia of the patella (HP:0006498)2.75015873
29Broad distal phalanx of finger (HP:0009836)2.74816127
30Testicular atrophy (HP:0000029)2.73223350
31Stridor (HP:0010307)2.71914912
32Large eyes (HP:0001090)2.70181332
33Oral leukoplakia (HP:0002745)2.69972307
34Renal duplication (HP:0000075)2.65052545
35Neuronal loss in central nervous system (HP:0002529)2.64037849
36Pendular nystagmus (HP:0012043)2.63905638
37Exercise-induced myalgia (HP:0003738)2.63457867
38Colon cancer (HP:0003003)2.60103056
39Nasal polyposis (HP:0100582)2.59519961
40Progressive muscle weakness (HP:0003323)2.55846627
41Insomnia (HP:0100785)2.55617345
42Abnormality of the fingertips (HP:0001211)2.54773679
43Diaphragmatic weakness (HP:0009113)2.54391839
44Truncus arteriosus (HP:0001660)2.54073928
45Hand muscle atrophy (HP:0009130)2.52954081
46Increased IgE level (HP:0003212)2.51121563
47Retinal dysplasia (HP:0007973)2.50395510
48Optic nerve coloboma (HP:0000588)2.50180860
49Abnormal respiratory motile cilium morphology (HP:0005938)2.46818274
50Abnormal respiratory epithelium morphology (HP:0012253)2.46818274
51Distal upper limb amyotrophy (HP:0007149)2.45370617
52Upper limb amyotrophy (HP:0009129)2.45370617
53Split foot (HP:0001839)2.44248306
54Short 4th metacarpal (HP:0010044)2.42804370
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42804370
56Trigonocephaly (HP:0000243)2.39497130
57Progressive external ophthalmoplegia (HP:0000590)2.38416919
58Astrocytoma (HP:0009592)2.37627662
59Abnormality of the astrocytes (HP:0100707)2.37627662
60Abnormality of the ileum (HP:0001549)2.37284013
61Abnormal gallbladder morphology (HP:0012437)2.36958357
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.36471986
63Meckel diverticulum (HP:0002245)2.32823499
64Abdominal situs inversus (HP:0003363)2.28474201
65Abnormality of abdominal situs (HP:0011620)2.28474201
66Broad alveolar ridges (HP:0000187)2.28215116
67Elfin facies (HP:0004428)2.27749694
68Hypercortisolism (HP:0001578)2.27724424
69Vertebral compression fractures (HP:0002953)2.27298242
70Recurrent otitis media (HP:0000403)2.26692704
71Hemorrhage of the eye (HP:0011885)2.23787805
72Panhypogammaglobulinemia (HP:0003139)2.23717490
73Bowel incontinence (HP:0002607)2.21506159
74Small intestinal stenosis (HP:0012848)2.20304029
75Duodenal stenosis (HP:0100867)2.20304029
76Overlapping toe (HP:0001845)2.19567259
77Reticulocytopenia (HP:0001896)2.17626291
78Supranuclear gaze palsy (HP:0000605)2.17380298
79Increased nuchal translucency (HP:0010880)2.16349693
80Renovascular hypertension (HP:0100817)2.15604290
81Abnormal respiratory motile cilium physiology (HP:0012261)2.15312342
82Megalocornea (HP:0000485)2.15304081
83Abnormality of the preputium (HP:0100587)2.12502954
84Abnormality of the gallbladder (HP:0005264)2.11472289
85Eczematoid dermatitis (HP:0000976)2.10942764
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09942927
87Prominent nose (HP:0000448)2.09655320
88Chronic bronchitis (HP:0004469)2.07446420
89Abnormality of the carotid arteries (HP:0005344)2.06108431
90Biconcave vertebral bodies (HP:0004586)2.05944108
91Pointed chin (HP:0000307)2.05844549
92Gastrointestinal inflammation (HP:0004386)2.05754836
93Abnormality of the aortic arch (HP:0012303)2.05723048
94Hypertensive crisis (HP:0100735)2.04605007
95Short philtrum (HP:0000322)2.03482695
96Abnormal large intestine physiology (HP:0012700)2.03468606
97Flat cornea (HP:0007720)2.01450996
98Abnormality of the duodenum (HP:0002246)2.01251306
99Overriding aorta (HP:0002623)2.01186614
100Hypoplasia of the pons (HP:0012110)2.00079093
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99104544
102Glioma (HP:0009733)1.98910081
103Bifid tongue (HP:0010297)1.98599162
104Neoplasm of the pancreas (HP:0002894)1.98551615
105Lissencephaly (HP:0001339)1.98387405
106Abnormal ciliary motility (HP:0012262)1.98278908
107Ulnar bowing (HP:0003031)1.97387862
108Neoplasm of the heart (HP:0100544)1.97380779
109Growth hormone excess (HP:0000845)1.97174757
110Infertility (HP:0000789)1.96918211
111Bony spicule pigmentary retinopathy (HP:0007737)1.96021121
112Tracheoesophageal fistula (HP:0002575)1.95858206
113Basal cell carcinoma (HP:0002671)1.95174758
114Abnormal number of erythroid precursors (HP:0012131)1.94983155
115Abnormality of reticulocytes (HP:0004312)1.93231256
116Chromsome breakage (HP:0040012)1.91807775
117Oligodactyly (HP:0012165)1.91655699
118Muscle stiffness (HP:0003552)1.91281683
119Cellulitis (HP:0100658)1.90895489
120Self-mutilation (HP:0000742)1.89620569
121Supernumerary spleens (HP:0009799)1.89506004
122Flattened epiphyses (HP:0003071)1.88895656
123Abnormality of the labia minora (HP:0012880)1.88523505
124Depression (HP:0000716)1.88287238
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88275318
126Broad face (HP:0000283)1.87765711
127Dislocated radial head (HP:0003083)1.87634495
128Spinal canal stenosis (HP:0003416)1.87054894
129Thin ribs (HP:0000883)1.86846711
130Myelodysplasia (HP:0002863)1.84447944
131Horseshoe kidney (HP:0000085)1.84103875
132Colitis (HP:0002583)1.83608288
133Abnormality of chromosome stability (HP:0003220)1.82667431
134Neoplasm of striated muscle (HP:0009728)1.82666949
135Peripheral hypomyelination (HP:0007182)1.81732667
136Villous atrophy (HP:0011473)1.81384214
137Abnormality of small intestinal villus morphology (HP:0011472)1.81384214
138Increased muscle lipid content (HP:0009058)1.81370017
139Long palpebral fissure (HP:0000637)1.81216507
140Rough bone trabeculation (HP:0100670)1.80728030
141Unilateral renal agenesis (HP:0000122)1.80409182
142Unsteady gait (HP:0002317)1.80152421
143Facial hemangioma (HP:0000329)1.79594243
144Dysphonia (HP:0001618)1.79337786
145Rhabdomyolysis (HP:0003201)1.78928636
146Abnormality of cells of the erythroid lineage (HP:0012130)1.78822357
147Degeneration of anterior horn cells (HP:0002398)1.78412736
148Abnormality of the anterior horn cell (HP:0006802)1.78412736
149Slender long bone (HP:0003100)1.77789240
150Hypoparathyroidism (HP:0000829)1.77517688
151Broad palm (HP:0001169)1.77510391
152Abnormality of midbrain morphology (HP:0002418)1.77365176
153Molar tooth sign on MRI (HP:0002419)1.77365176
154Abnormality of the metopic suture (HP:0005556)1.77314702
155Carpal bone hypoplasia (HP:0001498)1.76304331
156Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76017332
157Papilledema (HP:0001085)1.75957415
158Abnormality of the diencephalon (HP:0010662)1.74776252
159Bell-shaped thorax (HP:0001591)1.74302836
160Microretrognathia (HP:0000308)1.73706172
161Urethral obstruction (HP:0000796)1.72837464
162Tented upper lip vermilion (HP:0010804)1.72824458
163Gastrointestinal dysmotility (HP:0002579)1.72544336
164Abnormality of the 4th metacarpal (HP:0010012)1.71996770
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71991924
166Abnormality of the radial head (HP:0003995)1.71790812
167Obsessive-compulsive behavior (HP:0000722)1.71512806
168Spastic paraparesis (HP:0002313)1.71347672
169Triphalangeal thumb (HP:0001199)1.71220234
170Anteriorly placed anus (HP:0001545)1.71115269
171Abnormality of the calcaneus (HP:0008364)1.70814937
172External ophthalmoplegia (HP:0000544)1.70775957
173Abnormality of the nasal mucosa (HP:0000433)1.70673571
174Absent thumb (HP:0009777)1.70050754
175Aplasia/Hypoplasia of the sternum (HP:0006714)1.70034782
176Abnormality of skeletal muscle fiber size (HP:0012084)1.68644438
177Loss of speech (HP:0002371)1.68494511
178Hypotelorism (HP:0000601)1.67761661
179Easy fatigability (HP:0003388)1.67760611
180Sex reversal (HP:0012245)1.67559899
181Abnormal sex determination (HP:0012244)1.67559899
182Long eyelashes (HP:0000527)1.66733841
183Increased variability in muscle fiber diameter (HP:0003557)1.66284234
184Agnosia (HP:0010524)1.65629063
185Intestinal atresia (HP:0011100)1.63610066
186Abnormality of lateral ventricle (HP:0030047)1.63503548
187Granulocytopenia (HP:0001913)1.63074726
188Wide cranial sutures (HP:0010537)1.62553023
189Bronchitis (HP:0012387)1.62252351
190Deep palmar crease (HP:0006191)1.61822842
191Abnormality of the columella (HP:0009929)1.60410926
192Distal lower limb amyotrophy (HP:0008944)1.60121787
193Slow saccadic eye movements (HP:0000514)1.58046714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.33339546
2PRPF4B4.15982005
3CDC73.22594097
4EEF2K3.13701364
5KSR13.06293116
6DYRK32.97746905
7SMG12.64478879
8EPHB12.63362193
9MAP3K102.37508811
10ICK2.33786610
11MAPKAPK32.26999476
12MAPK152.07862653
13BUB11.93729192
14ERN11.91500917
15NEK21.83113534
16WEE11.80302529
17STK161.75146350
18CDK71.74249931
19PRKD31.67644126
20DYRK21.58945997
21DAPK11.57474674
22MAP2K31.56080034
23TGFBR11.53411471
24ATR1.52659275
25TGFBR21.49958048
26TESK11.48755523
27TAOK21.48612473
28KDR1.45569773
29EPHB21.37293318
30CDK81.37207600
31PASK1.35826928
32FLT31.35702601
33FGFR41.33036914
34TESK21.32724518
35CCNB11.32680359
36ACVR1B1.32123805
37CAMK1G1.31840760
38TAOK11.29756025
39SIK21.29343620
40SRPK11.29319545
41NEK11.28875070
42BCR1.27228697
43GRK61.21064319
44PAK41.20834948
45PLK11.18681745
46KIT1.17157412
47CSF1R1.16878654
48AURKA1.16663331
49CDK121.13950779
50RIPK41.11240139
51TNIK1.11009342
52CAMK1D1.08558462
53NTRK21.08081577
54CDK191.04367391
55TTK1.02970040
56AKT20.99774741
57BTK0.97482411
58RAF10.94697491
59ERBB20.93452514
60EPHA30.90802402
61MAP3K60.85077573
62CHEK20.84429960
63RPS6KA40.83116621
64PTK60.83106362
65TBK10.81941231
66MAP3K110.80511217
67PKN20.80424506
68LMTK20.79312636
69MAP2K20.77707167
70TYK20.76403179
71AURKB0.76318565
72VRK10.76007058
73MAP3K120.75313323
74VRK20.75164497
75CDK40.74885350
76MARK20.74605817
77UHMK10.72899710
78LRRK20.72200900
79RPS6KB20.70389422
80MINK10.68720230
81CAMKK10.67898633
82FES0.67881203
83MAP3K130.67273200
84BMX0.66599926
85MAPK130.65564991
86HIPK20.65160274
87MAP3K10.64547397
88BRAF0.63970491
89TRIB30.63682711
90RET0.62313051
91MKNK10.62281255
92CDK11A0.60747607
93IRAK20.59758496
94PNCK0.58152984
95CDK20.57148607
96MAPK110.55834123
97MAP4K10.55480956
98BCKDK0.55294161
99SCYL20.55155214
100MAP3K80.54937774
101ILK0.54552475
102STK380.54389471
103PIM20.53676390
104MAP3K70.53100246
105HCK0.52275159
106PAK60.52173671
107CDK90.52012654
108SIK10.51714710
109TYRO30.51388696
110CHEK10.50519060
111MAPK90.49741696
112CDK150.48916711
113MAPK120.48698207
114CDK140.48240453
115PDPK10.47948868
116DYRK1B0.47624661
117CSK0.47034467
118RPS6KL10.46966510
119RPS6KC10.46966510
120ARAF0.46578356
121TLK10.45096460
122RPS6KA20.45078544
123CAMK10.44925107
124IRAK30.44878953
125CDK60.44334440
126IRAK40.44211809
127MTOR0.42507316
128MAP3K90.42366169
129MAPK30.40664735
130TSSK60.40556689
131PRKD10.39903207
132MAP2K40.38946716
133ERBB30.38477112
134BRSK10.38308557
135EPHA20.37997404
136KSR20.37763652
137CDK10.37016477
138TNK20.35074908
139MAPK100.34426562
140PRKAA10.34226937
141PRKD20.34199252
142CDK180.33968698
143CAMK40.33490464
144JAK20.31763951
145ATM0.31379946
146BRD40.31227159
147CLK10.30511504
148ZAP700.30006927
149BMPR1B0.29966096
150PAK10.29783671

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.16985555
2Base excision repair_Homo sapiens_hsa034104.03932715
3Spliceosome_Homo sapiens_hsa030403.70651912
4Mismatch repair_Homo sapiens_hsa034303.68884723
5Cell cycle_Homo sapiens_hsa041102.84692581
6Nucleotide excision repair_Homo sapiens_hsa034202.33435867
7Homologous recombination_Homo sapiens_hsa034402.28542637
8RNA transport_Homo sapiens_hsa030132.19506137
9Notch signaling pathway_Homo sapiens_hsa043302.16399552
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99089109
11RNA degradation_Homo sapiens_hsa030181.98052253
12mRNA surveillance pathway_Homo sapiens_hsa030151.97578065
13Fanconi anemia pathway_Homo sapiens_hsa034601.97011361
14RNA polymerase_Homo sapiens_hsa030201.86569216
15Fructose and mannose metabolism_Homo sapiens_hsa000511.86331558
16Pyrimidine metabolism_Homo sapiens_hsa002401.84063036
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79220297
18Olfactory transduction_Homo sapiens_hsa047401.70476848
19Non-homologous end-joining_Homo sapiens_hsa034501.69703453
20One carbon pool by folate_Homo sapiens_hsa006701.61127631
21Colorectal cancer_Homo sapiens_hsa052101.52970429
22Basal cell carcinoma_Homo sapiens_hsa052171.51581415
23Choline metabolism in cancer_Homo sapiens_hsa052311.43075026
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42729749
25Ribosome_Homo sapiens_hsa030101.42550557
26N-Glycan biosynthesis_Homo sapiens_hsa005101.32255146
27Inositol phosphate metabolism_Homo sapiens_hsa005621.28456674
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25817830
29p53 signaling pathway_Homo sapiens_hsa041151.25530950
30Basal transcription factors_Homo sapiens_hsa030221.25085518
31Oocyte meiosis_Homo sapiens_hsa041141.24807791
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24264896
33Purine metabolism_Homo sapiens_hsa002301.19784091
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19222880
35T cell receptor signaling pathway_Homo sapiens_hsa046601.18565852
36HTLV-I infection_Homo sapiens_hsa051661.18048924
37ErbB signaling pathway_Homo sapiens_hsa040121.14888999
38Glioma_Homo sapiens_hsa052141.10832790
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08339515
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07758082
41Herpes simplex infection_Homo sapiens_hsa051681.07225744
42Chronic myeloid leukemia_Homo sapiens_hsa052201.03557855
43Proteasome_Homo sapiens_hsa030501.02382136
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00212663
45AMPK signaling pathway_Homo sapiens_hsa041520.99916588
46Endocytosis_Homo sapiens_hsa041440.93128413
47Hippo signaling pathway_Homo sapiens_hsa043900.93123655
48Renal cell carcinoma_Homo sapiens_hsa052110.92207265
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89990779
50Shigellosis_Homo sapiens_hsa051310.87485592
51Synaptic vesicle cycle_Homo sapiens_hsa047210.86144109
52Vibrio cholerae infection_Homo sapiens_hsa051100.84705511
53Sulfur relay system_Homo sapiens_hsa041220.84458352
54Hedgehog signaling pathway_Homo sapiens_hsa043400.83358490
55Epstein-Barr virus infection_Homo sapiens_hsa051690.82665838
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82412076
57Hepatitis B_Homo sapiens_hsa051610.81071963
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79353840
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78990803
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77366236
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76654600
62Viral carcinogenesis_Homo sapiens_hsa052030.75738378
63GnRH signaling pathway_Homo sapiens_hsa049120.74984445
64MicroRNAs in cancer_Homo sapiens_hsa052060.74797734
65Prostate cancer_Homo sapiens_hsa052150.72997346
66Pancreatic cancer_Homo sapiens_hsa052120.72911410
67Wnt signaling pathway_Homo sapiens_hsa043100.72587021
68Alcoholism_Homo sapiens_hsa050340.72513640
69Primary immunodeficiency_Homo sapiens_hsa053400.72075200
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.71225166
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.70851399
72Hepatitis C_Homo sapiens_hsa051600.70488306
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69654193
74Biosynthesis of amino acids_Homo sapiens_hsa012300.69584487
75Systemic lupus erythematosus_Homo sapiens_hsa053220.69239597
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68124552
77Acute myeloid leukemia_Homo sapiens_hsa052210.67122801
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.65833181
79Thyroid cancer_Homo sapiens_hsa052160.65763136
80Osteoclast differentiation_Homo sapiens_hsa043800.63581339
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63494218
82Long-term potentiation_Homo sapiens_hsa047200.61139547
83Estrogen signaling pathway_Homo sapiens_hsa049150.61042288
84VEGF signaling pathway_Homo sapiens_hsa043700.60452678
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58261752
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58193416
87Pathways in cancer_Homo sapiens_hsa052000.58104648
88Prolactin signaling pathway_Homo sapiens_hsa049170.58005402
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57509237
90Measles_Homo sapiens_hsa051620.57412941
91Bladder cancer_Homo sapiens_hsa052190.57292144
92Endometrial cancer_Homo sapiens_hsa052130.57150827
93B cell receptor signaling pathway_Homo sapiens_hsa046620.56687877
94Prion diseases_Homo sapiens_hsa050200.55874548
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55377579
96Non-small cell lung cancer_Homo sapiens_hsa052230.54785404
97Small cell lung cancer_Homo sapiens_hsa052220.54723061
98FoxO signaling pathway_Homo sapiens_hsa040680.53606761
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.53560474
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.53180021
101Selenocompound metabolism_Homo sapiens_hsa004500.53042604
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52741400
103Insulin resistance_Homo sapiens_hsa049310.51961043
104Circadian rhythm_Homo sapiens_hsa047100.51087803
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50489452
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50290514
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.50254866
108Other glycan degradation_Homo sapiens_hsa005110.49237483
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48375522
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48262956
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47759311
112Melanogenesis_Homo sapiens_hsa049160.47099883
113TGF-beta signaling pathway_Homo sapiens_hsa043500.46501053
114Regulation of autophagy_Homo sapiens_hsa041400.46295844
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.44955026
116Apoptosis_Homo sapiens_hsa042100.44798458
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44041501
118mTOR signaling pathway_Homo sapiens_hsa041500.43832214
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42807633
120Phototransduction_Homo sapiens_hsa047440.42487389
121Pentose phosphate pathway_Homo sapiens_hsa000300.41919022
122Adherens junction_Homo sapiens_hsa045200.40277678
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39588414
124Axon guidance_Homo sapiens_hsa043600.38377906
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37097132
126Insulin signaling pathway_Homo sapiens_hsa049100.36171894
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35647946
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33210299
129Lysine degradation_Homo sapiens_hsa003100.32392499
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31649124
131Gap junction_Homo sapiens_hsa045400.30564499
132Viral myocarditis_Homo sapiens_hsa054160.28253483
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28229268
134Galactose metabolism_Homo sapiens_hsa000520.26703642
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.26367756
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.25930924
137Influenza A_Homo sapiens_hsa051640.25414721
138Carbon metabolism_Homo sapiens_hsa012000.21572211

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