USP20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.19703062
2negative regulation of erythrocyte differentiation (GO:0045647)6.11560132
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.52305996
4negative regulation of cell killing (GO:0031342)5.52305996
5regulation of gamma-delta T cell differentiation (GO:0045586)5.10900161
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.91430374
7negative thymic T cell selection (GO:0045060)4.88615900
8positive thymic T cell selection (GO:0045059)4.79961890
9negative T cell selection (GO:0043383)4.77401871
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73546463
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.73380304
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.72886610
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69861556
14regulation of gamma-delta T cell activation (GO:0046643)4.69818528
15regulation of B cell receptor signaling pathway (GO:0050855)4.66151002
16response to interleukin-15 (GO:0070672)4.61796783
17antigen processing and presentation of endogenous antigen (GO:0019883)4.58869000
18thymic T cell selection (GO:0045061)4.53115320
19synaptic vesicle maturation (GO:0016188)4.52770371
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45248563
21leukocyte aggregation (GO:0070486)4.36440028
22positive regulation of B cell differentiation (GO:0045579)4.25741274
23positive T cell selection (GO:0043368)4.23244539
24locomotory exploration behavior (GO:0035641)4.15630907
25T cell selection (GO:0045058)4.13533808
26synaptic vesicle exocytosis (GO:0016079)4.07717265
27positive regulation of granulocyte differentiation (GO:0030854)4.05523596
28Peyers patch development (GO:0048541)4.03120874
29mucosal-associated lymphoid tissue development (GO:0048537)4.03120874
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.01791905
31vocalization behavior (GO:0071625)3.99249968
32cellular response to interleukin-15 (GO:0071350)3.97091481
33regulation of synaptic vesicle exocytosis (GO:2000300)3.92599124
34glutamate secretion (GO:0014047)3.89073929
35B cell receptor signaling pathway (GO:0050853)3.80405387
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79358812
37response to muramyl dipeptide (GO:0032495)3.78242685
38negative regulation of T cell mediated immunity (GO:0002710)3.74981259
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.68661873
40protein localization to synapse (GO:0035418)3.67581083
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.65191088
42activated T cell proliferation (GO:0050798)3.64926981
43neuronal action potential propagation (GO:0019227)3.61686036
44tolerance induction (GO:0002507)3.61160527
45regulation of B cell differentiation (GO:0045577)3.59126460
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55320373
47negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.55153026
48T cell migration (GO:0072678)3.54777092
49neuron cell-cell adhesion (GO:0007158)3.54313159
50dosage compensation (GO:0007549)3.54103259
51negative regulation of leukocyte mediated immunity (GO:0002704)3.51504428
52regulation of synaptic vesicle transport (GO:1902803)3.48646596
53regulation of synapse structural plasticity (GO:0051823)3.46995985
54negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.43018330
55layer formation in cerebral cortex (GO:0021819)3.40300920
56dendritic spine morphogenesis (GO:0060997)3.38664158
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36732354
58regulation of glutamate receptor signaling pathway (GO:1900449)3.34215736
59proline transport (GO:0015824)3.34061812
60exploration behavior (GO:0035640)3.32748627
61regulation of neuronal synaptic plasticity (GO:0048168)3.30383212
62sodium ion export (GO:0071436)3.30289294
63regulation of granulocyte differentiation (GO:0030852)3.29127914
64regulation of defense response to virus by virus (GO:0050690)3.28745722
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28384488
66neurotransmitter secretion (GO:0007269)3.26741291
67membrane depolarization during action potential (GO:0086010)3.26200199
68cell communication by electrical coupling (GO:0010644)3.25408959
69mannose metabolic process (GO:0006013)3.24976904
70ionotropic glutamate receptor signaling pathway (GO:0035235)3.23357986
71natural killer cell differentiation (GO:0001779)3.21614889
72activation of protein kinase A activity (GO:0034199)3.19446173
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.16402592
74regulation of natural killer cell mediated immunity (GO:0002715)3.16402592
75Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15694067
76cellular potassium ion homeostasis (GO:0030007)3.15629303
77detection of bacterium (GO:0016045)3.14675601
78synaptic vesicle docking involved in exocytosis (GO:0016081)3.13937281
79negative regulation of interleukin-12 production (GO:0032695)3.08892395
80detection of calcium ion (GO:0005513)3.08745484
81cell communication involved in cardiac conduction (GO:0086065)3.07685662
82regulation of interleukin-2 biosynthetic process (GO:0045076)3.07104972
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.06884870
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04200921
85megakaryocyte development (GO:0035855)3.03137627
86positive regulation of potassium ion transmembrane transport (GO:1901381)3.02604314
87detection of other organism (GO:0098543)3.02439763
88regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01171340
89neuromuscular process controlling posture (GO:0050884)3.00150353
90signal complex assembly (GO:0007172)3.00096647
91germinal center formation (GO:0002467)2.96990408
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95770081
93negative regulation of potassium ion transmembrane transport (GO:1901380)2.94803066
94neutrophil activation involved in immune response (GO:0002283)2.93040405
95synaptic transmission, glutamatergic (GO:0035249)2.92894345
96regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.92562605
97positive regulation of interleukin-4 production (GO:0032753)2.92154026
98vesicle transport along microtubule (GO:0047496)2.91477536
99regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.90962339
100regulation of histone H3-K27 methylation (GO:0061085)2.90648785
101positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89754249
102dendrite morphogenesis (GO:0048813)2.89139458
103negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88809991
104neuron recognition (GO:0008038)2.87977893
105oxygen transport (GO:0015671)2.87043563
106modulation by symbiont of host defense response (GO:0052031)2.87022363
107modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87022363
108modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87022363
109positive regulation by organism of defense response of other organism involved in symbiotic interact2.87022363
110modulation by symbiont of host immune response (GO:0052553)2.87022363
111positive regulation by symbiont of host defense response (GO:0052509)2.87022363
112leukocyte degranulation (GO:0043299)2.86763922
113cell migration in hindbrain (GO:0021535)2.85607522
114neurotransmitter transport (GO:0006836)2.83790721
115glutamate receptor signaling pathway (GO:0007215)2.83523006
116regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.83416332
117transmission of nerve impulse (GO:0019226)2.83394050
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83057550
119regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82825982
120positive regulation of potassium ion transport (GO:0043268)2.82257887
121GDP-mannose metabolic process (GO:0019673)2.81251527
122regulation of membrane repolarization (GO:0060306)2.80991754
123regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80884181
124antigen processing and presentation via MHC class Ib (GO:0002475)2.80625144
125neuronal ion channel clustering (GO:0045161)2.80002492
126cerebellar Purkinje cell differentiation (GO:0021702)2.79201376
127neuron-neuron synaptic transmission (GO:0007270)2.78638044
128antigen receptor-mediated signaling pathway (GO:0050851)2.77956211
129regulation of vesicle fusion (GO:0031338)2.77906159
130regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77823252
131T cell homeostasis (GO:0043029)2.77288758
132neuromuscular process controlling balance (GO:0050885)2.76467072
133calcium ion-dependent exocytosis (GO:0017156)2.75930196
134regulation of ARF protein signal transduction (GO:0032012)2.75101852
1353-UTR-mediated mRNA stabilization (GO:0070935)2.74631019
136cerebellar Purkinje cell layer development (GO:0021680)2.73882574
137positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73334877
138cellular response to interleukin-4 (GO:0071353)2.73164662
139regulation of mast cell degranulation (GO:0043304)2.73133663
140axon cargo transport (GO:0008088)2.72788724
141gamma-aminobutyric acid transport (GO:0015812)2.72475990
142organelle transport along microtubule (GO:0072384)2.72473152
143regulation of calcium ion transmembrane transport (GO:1903169)2.72197062
144regulation of calcium ion transmembrane transporter activity (GO:1901019)2.72197062
145potassium ion import (GO:0010107)2.71543652
146plasma membrane repair (GO:0001778)2.70346975
147glycine transport (GO:0015816)2.70344869
148positive regulation of membrane potential (GO:0045838)2.69709180
149mating behavior (GO:0007617)2.69177305
150regulation of interleukin-4 production (GO:0032673)2.68879079
151cellular extravasation (GO:0045123)2.68133255
152membrane depolarization (GO:0051899)2.67172848
153membrane repolarization (GO:0086009)2.66965984
154regulation of neurotransmitter secretion (GO:0046928)2.66438716
155regulation of alpha-beta T cell proliferation (GO:0046640)2.66365179
156mast cell activation (GO:0045576)2.66044758
157lymphocyte homeostasis (GO:0002260)2.65990727
158regulation of leukocyte degranulation (GO:0043300)2.65965347
159potassium ion homeostasis (GO:0055075)2.65931390
160regulation of postsynaptic membrane potential (GO:0060078)2.65840995
161positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.64647636
162response to auditory stimulus (GO:0010996)2.63238167
163cellular response to ATP (GO:0071318)2.63215297
164synaptic vesicle endocytosis (GO:0048488)2.63151663
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62543690
166T cell receptor signaling pathway (GO:0050852)2.62522615
167auditory behavior (GO:0031223)2.61484674
168detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.60753015
169detection of temperature stimulus involved in sensory perception (GO:0050961)2.60753015
170regulation of T cell mediated cytotoxicity (GO:0001914)2.60698907
171negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.60495160
172regulation of dendritic spine morphogenesis (GO:0061001)2.60350426
173neuronal action potential (GO:0019228)2.59884485
174long-term memory (GO:0007616)2.59842098
175response to interleukin-4 (GO:0070670)2.59207206
176axonal fasciculation (GO:0007413)2.59048908
177interferon-gamma production (GO:0032609)2.58725776
178striatum development (GO:0021756)2.58608762
179membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.58266780
180gas transport (GO:0015669)2.57150638
181positive regulation of natural killer cell mediated immunity (GO:0002717)2.56909692
182regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.56749097
183negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56403859
184regulation of neurotransmitter levels (GO:0001505)2.56272817
185negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56144216
186negative regulation of T-helper cell differentiation (GO:0045623)2.56144216
187negative regulation of microtubule polymerization (GO:0031115)2.55737887
188neurotransmitter-gated ion channel clustering (GO:0072578)2.54700539
189regulation of synaptic plasticity (GO:0048167)2.54663282
190cytoskeletal anchoring at plasma membrane (GO:0007016)2.54457447
191positive regulation of T cell mediated cytotoxicity (GO:0001916)2.54359135
192regulation of voltage-gated calcium channel activity (GO:1901385)2.53648986
193regulation of erythrocyte differentiation (GO:0045646)2.53076239
194regulation of leukocyte mediated cytotoxicity (GO:0001910)2.52541008
195N-acetylneuraminate metabolic process (GO:0006054)2.52064799
196regulation of T cell tolerance induction (GO:0002664)2.52009559
197regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50919385
198response to peptidoglycan (GO:0032494)2.50823195
199response to type I interferon (GO:0034340)2.50418111
200positive regulation of Rap GTPase activity (GO:0032854)2.49957297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45059028
2VDR_21846776_ChIP-Seq_THP-1_Human3.37595335
3MYC_22102868_ChIP-Seq_BL_Human3.35762679
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89166939
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78195851
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76531627
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.66759791
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66560099
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64775880
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.62345938
11MAF_26560356_Chip-Seq_TH1_Human2.58375828
12GBX2_23144817_ChIP-Seq_PC3_Human2.56043234
13* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.54646180
14KDM2B_26808549_Chip-Seq_DND41_Human2.50428996
15TCF7_22412390_ChIP-Seq_EML_Mouse2.48829467
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48315942
17LXR_22292898_ChIP-Seq_THP-1_Human2.45879925
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45708742
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44956355
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44956355
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44563875
22DROSHA_22980978_ChIP-Seq_HELA_Human2.43205111
23UTX_26944678_Chip-Seq_JUKART_Human2.42299987
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38475455
25SCL_19346495_ChIP-Seq_HPC-7_Human2.35602348
26REST_21632747_ChIP-Seq_MESCs_Mouse2.34417169
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31137128
28EZH2_27304074_Chip-Seq_ESCs_Mouse2.30933557
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.27114007
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.25914641
31VDR_24763502_ChIP-Seq_THP-1_Human2.24386777
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24261361
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23991382
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22265975
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22264795
36MAF_26560356_Chip-Seq_TH2_Human2.18453765
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16287413
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13866844
39RUNX1_22412390_ChIP-Seq_EML_Mouse2.12177054
40ELK3_25401928_ChIP-Seq_HUVEC_Human2.08137263
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07266195
42EGR1_19374776_ChIP-ChIP_THP-1_Human2.04382185
43RNF2_27304074_Chip-Seq_ESCs_Mouse2.02130552
44BP1_19119308_ChIP-ChIP_Hs578T_Human2.01595856
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.99678978
46* RUNX_20019798_ChIP-Seq_JUKART_Human1.97562463
47* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97172543
48SPI1_23127762_ChIP-Seq_K562_Human1.93931622
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.93731940
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93501284
51GATA1_19941826_ChIP-Seq_K562_Human1.93119006
52MYB_26560356_Chip-Seq_TH2_Human1.90709057
53* GATA1_19941827_ChIP-Seq_MEL_Mouse1.85353291
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83096188
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.81005487
56* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.80347374
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79646446
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79309326
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77804606
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77389789
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76571103
62MYB_26560356_Chip-Seq_TH1_Human1.76080005
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74485308
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74351943
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67989284
66* NCOR1_26117541_ChIP-Seq_K562_Human1.67979594
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67013225
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.65015191
69ZNF274_21170338_ChIP-Seq_K562_Hela1.63652383
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63537861
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62431092
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61638361
73P68_20966046_ChIP-Seq_HELA_Human1.59511740
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55583118
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.54977071
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53287066
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50345600
78* SPI1_23547873_ChIP-Seq_NB4_Human1.49314493
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.46747326
80BCOR_27268052_Chip-Seq_Bcells_Human1.43023361
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39994954
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39636272
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39174926
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38676416
85TAF15_26573619_Chip-Seq_HEK293_Human1.38047613
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.36466967
87AR_21572438_ChIP-Seq_LNCaP_Human1.35988625
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35607594
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35581673
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35549333
91CIITA_25753668_ChIP-Seq_RAJI_Human1.34608062
92BCL6_27268052_Chip-Seq_Bcells_Human1.34447227
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34322567
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.34231162
95SMAD4_21799915_ChIP-Seq_A2780_Human1.34048916
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31054202
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.30870575
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30357871
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29404295
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.28517518
101ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28503174
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28027184
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27554547
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27538295
105SMC4_20622854_ChIP-Seq_HELA_Human1.27373188
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27241498
107RACK7_27058665_Chip-Seq_MCF-7_Human1.27197046
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26739026
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26530017
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24883949
111GATA3_27048872_Chip-Seq_THYMUS_Human1.24405838
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.24256688
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22718927
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22610523
115GATA2_19941826_ChIP-Seq_K562_Human1.21153236
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20517474
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20086472
118IRF8_21731497_ChIP-ChIP_J774_Mouse1.19954700
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19714325
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19501196
121* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19367204
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19136770
123CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18763065
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18636995
125TET1_21451524_ChIP-Seq_MESCs_Mouse1.17038945
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.16989224
127CTCF_26484167_Chip-Seq_Bcells_Mouse1.15994578
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15497569
129CTCF_27219007_Chip-Seq_Bcells_Human1.14971682
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14767761
131* KDM2B_26808549_Chip-Seq_K562_Human1.13131520
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11088689
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10621245
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10480655
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10439439
136CBX2_27304074_Chip-Seq_ESCs_Mouse1.08473254
137SMAD3_21741376_ChIP-Seq_EPCs_Human1.08402038
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08333784
139CREB1_26743006_Chip-Seq_LNCaP_Human1.07903404
140* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07774599
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07656795
142* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07133894
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06926026
144GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05758390
145* STAT3_23295773_ChIP-Seq_U87_Human1.05314500
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04901694
147AHR_22903824_ChIP-Seq_MCF-7_Human1.03761554
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03665567
149ARNT_22903824_ChIP-Seq_MCF-7_Human1.02615326
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02464502
151ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02005161
152ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01576431
153* AR_19668381_ChIP-Seq_PC3_Human1.01379115
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01307011
155CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00929480
156VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00675099
157CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00537787
158TET1_21490601_ChIP-Seq_MESCs_Mouse0.98927895
159TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98486746
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97863553
161CTCF_21964334_Chip-Seq_Bcells_Human0.97415241
162ESR2_21235772_ChIP-Seq_MCF-7_Human0.97029095
163AR_25329375_ChIP-Seq_VCAP_Human0.96962723
164OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95772618
165WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95525572
166RING1B_27294783_Chip-Seq_NPCs_Mouse0.95258666
167BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95149904
168PIAS1_25552417_ChIP-Seq_VCAP_Human0.94979880
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93891438
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93455279
171TCF4_23295773_ChIP-Seq_U87_Human0.92834312
172SMAD4_21741376_ChIP-Seq_HESCs_Human0.92352279
173SMAD3_21741376_ChIP-Seq_ESCs_Human0.92146136
174ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90994857
175* P300_19829295_ChIP-Seq_ESCs_Human0.90644762
176P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89434805
177YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88437137
178GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87049626
179SMAD3_21741376_ChIP-Seq_HESCs_Human0.86041577
180RNF2_27304074_Chip-Seq_NSC_Mouse0.85698673
181ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84856275
182SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84816527
183GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82903277
184AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81575411
185PRDM14_20953172_ChIP-Seq_ESCs_Human0.78453055
186ESR1_20079471_ChIP-ChIP_T-47D_Human0.78327710
187NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78137708
188SMAD4_21741376_ChIP-Seq_EPCs_Human0.77921894
189RUNX2_22187159_ChIP-Seq_PCA_Human0.77020726
190EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76511902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.96391582
2MP0004270_analgesia4.01672105
3MP0003763_abnormal_thymus_physiology3.89762083
4MP0003436_decreased_susceptibility_to3.87893698
5MP0003300_gastrointestinal_ulcer3.83744377
6MP0003880_abnormal_central_pattern3.79477902
7MP0003635_abnormal_synaptic_transmissio3.30954638
8MP0005671_abnormal_response_to2.93475008
9MP0003303_peritoneal_inflammation2.93448397
10MP0001968_abnormal_touch/_nociception2.75540906
11MP0009745_abnormal_behavioral_response2.67292389
12MP0001800_abnormal_humoral_immune2.63701226
13MP0002837_dystrophic_cardiac_calcinosis2.61137701
14MP0002064_seizures2.60291173
15MP0003724_increased_susceptibility_to2.59476540
16MP0002822_catalepsy2.58398471
17MP0001835_abnormal_antigen_presentation2.57903141
18MP0002734_abnormal_mechanical_nocicepti2.57666710
19MP0005464_abnormal_platelet_physiology2.55190218
20MP0002735_abnormal_chemical_nociception2.54390597
21MP0002063_abnormal_learning/memory/cond2.51068553
22MP0005000_abnormal_immune_tolerance2.50701129
23MP0009278_abnormal_bone_marrow2.49071696
24MP0002396_abnormal_hematopoietic_system2.47753318
25MP0009046_muscle_twitch2.46701430
26MP0005025_abnormal_response_to2.46448121
27MP0009333_abnormal_splenocyte_physiolog2.43628923
28MP0005451_abnormal_body_composition2.41901413
29MP0002420_abnormal_adaptive_immunity2.41306375
30MP0002723_abnormal_immune_serum2.38896449
31MP0005387_immune_system_phenotype2.38243348
32MP0001790_abnormal_immune_system2.38243348
33MP0001819_abnormal_immune_cell2.37921847
34MP0000751_myopathy2.35975035
35MP0002398_abnormal_bone_marrow2.33758497
36MP0003329_amyloid_beta_deposits2.33533848
37MP0002272_abnormal_nervous_system2.32922183
38MP0000703_abnormal_thymus_morphology2.30845409
39MP0002419_abnormal_innate_immunity2.29949748
40MP0000685_abnormal_immune_system2.29637176
41MP0002736_abnormal_nociception_after2.23737380
42MP0002572_abnormal_emotion/affect_behav2.17447179
43MP0002452_abnormal_antigen_presenting2.16846585
44MP0002733_abnormal_thermal_nociception2.16498250
45MP0006276_abnormal_autonomic_nervous2.10863794
46MP0005423_abnormal_somatic_nervous2.08479822
47MP0004947_skin_inflammation2.05381794
48MP0002909_abnormal_adrenal_gland2.04735778
49MP0001486_abnormal_startle_reflex2.04167716
50MP0004858_abnormal_nervous_system2.03962935
51MP0010155_abnormal_intestine_physiology2.02845281
52MP0001440_abnormal_grooming_behavior2.00294951
53MP0001970_abnormal_pain_threshold1.98392434
54MP0000716_abnormal_immune_system1.95334558
55MP0002722_abnormal_immune_system1.92742115
56MP0003866_abnormal_defecation1.92444595
57MP0009785_altered_susceptibility_to1.91334717
58MP0003172_abnormal_lysosome_physiology1.90218335
59MP0002405_respiratory_system_inflammati1.89047615
60MP0001873_stomach_inflammation1.87818700
61MP0000689_abnormal_spleen_morphology1.81844307
62MP0005076_abnormal_cell_differentiation1.78861486
63MP0002067_abnormal_sensory_capabilities1.75878740
64MP0009780_abnormal_chondrocyte_physiolo1.75689190
65MP0008260_abnormal_autophagy1.69673960
66MP0008569_lethality_at_weaning1.69275190
67MP0005397_hematopoietic_system_phenotyp1.68661856
68MP0001545_abnormal_hematopoietic_system1.68661856
69MP0002429_abnormal_blood_cell1.68147838
70MP0002184_abnormal_innervation1.68072660
71MP0000778_abnormal_nervous_system1.67365768
72MP0005410_abnormal_fertilization1.66116849
73MP0005058_abnormal_lysosome_morphology1.65168724
74MP0001851_eye_inflammation1.59863803
75MP0002009_preneoplasia1.58624534
76MP0001501_abnormal_sleep_pattern1.55451526
77MP0000955_abnormal_spinal_cord1.54834441
78MP0004215_abnormal_myocardial_fiber1.52407902
79MP0004811_abnormal_neuron_physiology1.52106541
80MP0001533_abnormal_skeleton_physiology1.51621732
81MP0003879_abnormal_hair_cell1.50957235
82MP0004808_abnormal_hematopoietic_stem1.47216545
83MP0004145_abnormal_muscle_electrophysio1.46904894
84MP0000465_gastrointestinal_hemorrhage1.46187514
85MP0004381_abnormal_hair_follicle1.45780371
86MP0005386_behavior/neurological_phenoty1.45415708
87MP0004924_abnormal_behavior1.45415708
88MP0001529_abnormal_vocalization1.45178221
89MP0004036_abnormal_muscle_relaxation1.43482849
90MP0001845_abnormal_inflammatory_respons1.42035306
91MP0002148_abnormal_hypersensitivity_rea1.41437605
92MP0000747_muscle_weakness1.37742246
93MP0004885_abnormal_endolymph1.36639133
94MP0001905_abnormal_dopamine_level1.36353691
95MP0002882_abnormal_neuron_morphology1.36094826
96MP0002557_abnormal_social/conspecific_i1.35883623
97MP0003656_abnormal_erythrocyte_physiolo1.34942056
98MP0000920_abnormal_myelination1.34689886
99MP0004084_abnormal_cardiac_muscle1.31503532
100MP0002066_abnormal_motor_capabilities/c1.30939448
101MP0003137_abnormal_impulse_conducting1.30919037
102MP0003633_abnormal_nervous_system1.30351422
103MP0000749_muscle_degeneration1.30306254
104MP0003646_muscle_fatigue1.30211207
105MP0000013_abnormal_adipose_tissue1.24489705
106MP0004085_abnormal_heartbeat1.24468900
107MP0002166_altered_tumor_susceptibility1.22433812
108MP0003191_abnormal_cellular_cholesterol1.22239802
109MP0005646_abnormal_pituitary_gland1.19596849
110MP0002229_neurodegeneration1.17289146
111MP0004043_abnormal_pH_regulation1.17255293
112MP0003634_abnormal_glial_cell1.15516271
113MP0005645_abnormal_hypothalamus_physiol1.10924820
114MP0003631_nervous_system_phenotype1.09648327
115MP0006082_CNS_inflammation1.09351679
116MP0001984_abnormal_olfaction1.08863708
117MP0009840_abnormal_foam_cell1.08664156
118MP0004142_abnormal_muscle_tone1.08496938
119MP0004185_abnormal_adipocyte_glucose1.08023990
120MP0008961_abnormal_basal_metabolism1.07131192
121MP0000858_altered_metastatic_potential1.06499176
122MP0003283_abnormal_digestive_organ1.05676879
123MP0008469_abnormal_protein_level1.05348766
124MP0003828_pulmonary_edema1.03182705
125MP0002132_abnormal_respiratory_system1.02916091
126MP0005623_abnormal_meninges_morphology1.02841762
127MP0000678_abnormal_parathyroid_gland1.01316754
128MP0001485_abnormal_pinna_reflex0.97982841
129MP0004742_abnormal_vestibular_system0.96511820
130MP0001502_abnormal_circadian_rhythm0.96191776
131MP0005620_abnormal_muscle_contractility0.96055417
132MP0000604_amyloidosis0.95572693
133MP0005310_abnormal_salivary_gland0.93637603
134MP0002972_abnormal_cardiac_muscle0.93544163
135MP0002998_abnormal_bone_remodeling0.93032464
136MP0001299_abnormal_eye_distance/0.92472753
137MP0002152_abnormal_brain_morphology0.91668329
138MP0004510_myositis0.90974889
139MP0005535_abnormal_body_temperature0.90306283
140MP0003122_maternal_imprinting0.89095093
141MP0004130_abnormal_muscle_cell0.88827494
142MP0005083_abnormal_biliary_tract0.86693051
143MP0004233_abnormal_muscle_weight0.86403701
144MP0005330_cardiomyopathy0.84688910
145MP0002069_abnormal_eating/drinking_beha0.83455520
146MP0001765_abnormal_ion_homeostasis0.83272620
147MP0004087_abnormal_muscle_fiber0.82029899
148MP0008874_decreased_physiological_sensi0.81606600
149MP0000490_abnormal_crypts_of0.80012499
150MP0002752_abnormal_somatic_nervous0.79948017
151MP0001663_abnormal_digestive_system0.79796963
152MP0004147_increased_porphyrin_level0.79586118
153MP0010386_abnormal_urinary_bladder0.79541697
154MP0004484_altered_response_of0.79322977
155MP0003632_abnormal_nervous_system0.78871971
156MP0002106_abnormal_muscle_physiology0.78202943
157MP0003787_abnormal_imprinting0.77658671
158MP0002269_muscular_atrophy0.77577237
159MP0002933_joint_inflammation0.76048502
160MP0000759_abnormal_skeletal_muscle0.75999881
161MP0003453_abnormal_keratinocyte_physiol0.75798559
162MP0003448_altered_tumor_morphology0.75258754
163MP0002019_abnormal_tumor_incidence0.73972497
164MP0005621_abnormal_cell_physiology0.71451019
165MP0005551_abnormal_eye_electrophysiolog0.71322272
166MP0003690_abnormal_glial_cell0.70916021
167MP0009764_decreased_sensitivity_to0.70898270
168MP0005369_muscle_phenotype0.70364470
169MP0001348_abnormal_lacrimal_gland0.70050564
170MP0001963_abnormal_hearing_physiology0.67548131
171MP0001986_abnormal_taste_sensitivity0.67014028
172MP0000681_abnormal_thyroid_gland0.66535766
173MP0002234_abnormal_pharynx_morphology0.66393430
174MP0002751_abnormal_autonomic_nervous0.66178753
175MP0005666_abnormal_adipose_tissue0.64410606
176MP0003045_fibrosis0.64356356
177MP0005166_decreased_susceptibility_to0.64070074
178MP0003091_abnormal_cell_migration0.63891119
179MP0001849_ear_inflammation0.63736095
180MP0002006_tumorigenesis0.62931051
181MP0005075_abnormal_melanosome_morpholog0.62166787
182MP0005390_skeleton_phenotype0.61722739
183MP0009931_abnormal_skin_appearance0.61285950
184MP0001853_heart_inflammation0.60944243
185MP0009765_abnormal_xenobiotic_induced0.60789350
186MP0000470_abnormal_stomach_morphology0.60009913
187MP0003075_altered_response_to0.59584001
188MP0009763_increased_sensitivity_to0.57168131
189MP0003795_abnormal_bone_structure0.56267442
190MP0005584_abnormal_enzyme/coenzyme_acti0.54551689

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.87216971
2Myokymia (HP:0002411)5.35609032
3Visual hallucinations (HP:0002367)4.87075864
4Eczematoid dermatitis (HP:0000976)4.73858081
5Focal seizures (HP:0007359)4.62375993
6Stomatitis (HP:0010280)4.34082539
7Supranuclear gaze palsy (HP:0000605)3.91235062
8Prolonged bleeding time (HP:0003010)3.79734117
9Hypochromic microcytic anemia (HP:0004840)3.75963360
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.73735318
11Absence seizures (HP:0002121)3.57738886
12Pheochromocytoma (HP:0002666)3.56781575
13Action tremor (HP:0002345)3.56416119
14Myositis (HP:0100614)3.48746794
15Elevated erythrocyte sedimentation rate (HP:0003565)3.47847376
16Panhypogammaglobulinemia (HP:0003139)3.37610736
17Recurrent fungal infections (HP:0002841)3.35341836
18Ankle clonus (HP:0011448)3.34216042
19Increased IgE level (HP:0003212)3.32936318
20Sudden death (HP:0001699)3.32263560
21Chronic obstructive pulmonary disease (HP:0006510)3.29144642
22Obstructive lung disease (HP:0006536)3.29144642
23Myopathic facies (HP:0002058)3.27220255
24Pustule (HP:0200039)3.23626127
25Hypochromic anemia (HP:0001931)3.20521384
26Dialeptic seizures (HP:0011146)3.18954499
27Recurrent abscess formation (HP:0002722)3.16799622
28Atonic seizures (HP:0010819)3.15779981
29Ventricular fibrillation (HP:0001663)3.14748598
30Neurofibrillary tangles (HP:0002185)3.13403445
31Abnormality of the fingertips (HP:0001211)3.13394006
32Recurrent bacterial skin infections (HP:0005406)3.07537490
33Progressive cerebellar ataxia (HP:0002073)3.06958416
34Abnormality of macrophages (HP:0004311)3.06066708
35Neuroendocrine neoplasm (HP:0100634)3.04366555
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.04004773
37Abnormality of DNA repair (HP:0003254)3.01410833
38Epileptic encephalopathy (HP:0200134)2.98775703
39Recurrent viral infections (HP:0004429)2.87731464
40Termporal pattern (HP:0011008)2.86926601
41Insidious onset (HP:0003587)2.86926601
42Meningitis (HP:0001287)2.85027292
43Cerebral inclusion bodies (HP:0100314)2.84733291
44Gastrointestinal infarctions (HP:0005244)2.84697777
45Generalized tonic-clonic seizures (HP:0002069)2.83381315
46Spontaneous hematomas (HP:0007420)2.81318954
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.80101429
48Gastrointestinal inflammation (HP:0004386)2.79039164
49Epistaxis (HP:0000421)2.78438437
50Exercise-induced myalgia (HP:0003738)2.77323993
51Obstructive sleep apnea (HP:0002870)2.73365702
52Bundle branch block (HP:0011710)2.72855810
53Colitis (HP:0002583)2.71848853
54Seborrheic dermatitis (HP:0001051)2.68756957
55Depression (HP:0000716)2.68502675
56Cellulitis (HP:0100658)2.68168584
57T lymphocytopenia (HP:0005403)2.67768012
58Hyporeflexia of lower limbs (HP:0002600)2.66337219
59Granulocytopenia (HP:0001913)2.65697947
60Urinary urgency (HP:0000012)2.64827655
61Prolonged QT interval (HP:0001657)2.64766996
62Spastic gait (HP:0002064)2.63141143
63Orchitis (HP:0100796)2.63081873
64Truncus arteriosus (HP:0001660)2.62990057
65Encephalitis (HP:0002383)2.62743102
66Abnormality of the corticospinal tract (HP:0002492)2.61623780
67Polycythemia (HP:0001901)2.61285294
68Inflammation of the large intestine (HP:0002037)2.60854371
69Recurrent cutaneous fungal infections (HP:0011370)2.57354314
70Chronic mucocutaneous candidiasis (HP:0002728)2.57354314
71Rapidly progressive (HP:0003678)2.55749778
72Urinary bladder sphincter dysfunction (HP:0002839)2.54183496
73Syncope (HP:0001279)2.53313012
74Reticulocytosis (HP:0001923)2.53171739
75Dysmetria (HP:0001310)2.52918573
76Abnormality of T cells (HP:0002843)2.51839586
77Febrile seizures (HP:0002373)2.49699342
78Thoracic kyphosis (HP:0002942)2.49264164
79Ulnar claw (HP:0001178)2.49059940
80Hypertensive crisis (HP:0100735)2.48704133
81Microcytic anemia (HP:0001935)2.47761748
82Truncal ataxia (HP:0002078)2.46486197
83Petechiae (HP:0000967)2.45294439
84Anxiety (HP:0000739)2.44877639
85Impaired vibration sensation in the lower limbs (HP:0002166)2.44419863
86Mediastinal lymphadenopathy (HP:0100721)2.44149428
87Calf muscle hypertrophy (HP:0008981)2.42648209
88Retrobulbar optic neuritis (HP:0100654)2.42112548
89Optic neuritis (HP:0100653)2.42112548
90Abnormal gallbladder physiology (HP:0012438)2.41123631
91Cholecystitis (HP:0001082)2.41123631
92Postural instability (HP:0002172)2.40821261
93Basal cell carcinoma (HP:0002671)2.39322564
94Muscle hypertrophy of the lower extremities (HP:0008968)2.37128425
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.35839242
96Abnormality of T cell number (HP:0011839)2.35490336
97Papilledema (HP:0001085)2.35048788
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34103144
99Degeneration of the lateral corticospinal tracts (HP:0002314)2.34103144
100Abnormality of T cell physiology (HP:0011840)2.33970546
101Vasculitis (HP:0002633)2.33422268
102Onion bulb formation (HP:0003383)2.32204834
103Agammaglobulinemia (HP:0004432)2.31978645
104Hyperthyroidism (HP:0000836)2.29132273
105Dynein arm defect of respiratory motile cilia (HP:0012255)2.29112347
106Absent/shortened dynein arms (HP:0200106)2.29112347
107Chest pain (HP:0100749)2.27106135
108Slow saccadic eye movements (HP:0000514)2.26975721
109Abnormality of the lower motor neuron (HP:0002366)2.26258172
110Recurrent skin infections (HP:0001581)2.24886657
111Abnormality of the calf musculature (HP:0001430)2.24340646
112Abnormality of the thoracic spine (HP:0100711)2.24102438
113Gaze-evoked nystagmus (HP:0000640)2.23083205
114Abnormal EKG (HP:0003115)2.22536233
115Urticaria (HP:0001025)2.22444646
116Dysdiadochokinesis (HP:0002075)2.21566987
117Bowel incontinence (HP:0002607)2.21541515
118Lower limb muscle weakness (HP:0007340)2.19510966
119Abnormal eating behavior (HP:0100738)2.18725270
120Autoimmune hemolytic anemia (HP:0001890)2.18664845
121Abnormal platelet volume (HP:0011876)2.17258951
122Poor eye contact (HP:0000817)2.16745452
123Metaphyseal cupping (HP:0003021)2.16087057
124Intention tremor (HP:0002080)2.15836712
125Hammertoe (HP:0001765)2.13516486
126Hypoproteinemia (HP:0003075)2.12804116
127Peripheral hypomyelination (HP:0007182)2.12419919
128Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12385578
129Hypoplasia of the brainstem (HP:0002365)2.12385578
130Increased circulating renin level (HP:0000848)2.12057945
131Severe combined immunodeficiency (HP:0004430)2.11637376
132Gingivitis (HP:0000230)2.11103938
133Fetal akinesia sequence (HP:0001989)2.09623092
134Atrial fibrillation (HP:0005110)2.09243224
135Verrucae (HP:0200043)2.08615666
136Papilloma (HP:0012740)2.08615666
137Difficulty running (HP:0009046)2.08581867
138Abnormal platelet function (HP:0011869)2.08300277
139Impaired platelet aggregation (HP:0003540)2.08300277
140Impaired social interactions (HP:0000735)2.07895650
141Abnormal social behavior (HP:0012433)2.07895650
142Increased serum ferritin (HP:0003281)2.07601308
143Keratoconjunctivitis sicca (HP:0001097)2.06986558
144Foot dorsiflexor weakness (HP:0009027)2.06943284
145Abnormal large intestine physiology (HP:0012700)2.06079109
146Leukocytosis (HP:0001974)2.06065747
147Primary atrial arrhythmia (HP:0001692)2.05762010
148Fatigue (HP:0012378)2.05285689
149Limb dystonia (HP:0002451)2.04857914
150Reduced antithrombin III activity (HP:0001976)2.04377006
151Myotonia (HP:0002486)2.04006275
152Purpura (HP:0000979)2.03838598
153Annular pancreas (HP:0001734)2.03338152
154Muscle fiber splitting (HP:0003555)2.01276785
155Akinesia (HP:0002304)2.00502878
156Amblyopia (HP:0000646)1.99573072
157Agitation (HP:0000713)1.99229094
158Hypercortisolism (HP:0001578)1.98529084
159Steppage gait (HP:0003376)1.97683897
160Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97346215
161Gastrointestinal stroma tumor (HP:0100723)1.97058159
162Recurrent gram-negative bacterial infections (HP:0005420)1.97052857
163Thin bony cortex (HP:0002753)1.96867851
164Broad-based gait (HP:0002136)1.96634879
165Abnormality of the foot musculature (HP:0001436)1.96554958
166Torticollis (HP:0000473)1.96188684
167Scanning speech (HP:0002168)1.94587801
168Dysmetric saccades (HP:0000641)1.92134072
169Arterial thrombosis (HP:0004420)1.91706069
170Ventricular arrhythmia (HP:0004308)1.91542820
171Neoplasm of the peripheral nervous system (HP:0100007)1.89345137
172Increased IgM level (HP:0003496)1.89266079
173Supraventricular tachycardia (HP:0004755)1.88557261
174Neuronal loss in central nervous system (HP:0002529)1.86958230
175Neoplasm of the heart (HP:0100544)1.86908628
176Cholelithiasis (HP:0001081)1.86661538
177Gingival bleeding (HP:0000225)1.85361823
178Abnormality of binocular vision (HP:0011514)1.85352819
179Diplopia (HP:0000651)1.85352819
180Mutism (HP:0002300)1.84518507
181Abnormality of calcium-phosphate metabolism (HP:0100530)1.83910912
182Supraventricular arrhythmia (HP:0005115)1.83060704
183Oligomenorrhea (HP:0000876)1.82505171
184Hypergammaglobulinemia (HP:0010702)1.81648122
185Hemiparesis (HP:0001269)1.81497652
186Psychosis (HP:0000709)1.81104258
187EEG with generalized epileptiform discharges (HP:0011198)1.81007277
188Epileptiform EEG discharges (HP:0011182)1.80738411
189Type II lissencephaly (HP:0007260)1.80559093
190Episodic fever (HP:0001954)1.80403590
191Abnormality of iron homeostasis (HP:0011031)1.80371389
192Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80273055
193Bradycardia (HP:0001662)1.80139695
194Rigidity (HP:0002063)1.80067300
195Decreased motor nerve conduction velocity (HP:0003431)1.79884157
196Lymphopenia (HP:0001888)1.79183905
197Retinal dysplasia (HP:0007973)1.78942362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.45494323
2NTRK33.42460968
3MAP3K93.31233414
4NTRK12.59199501
5PRKD32.54802711
6EPHA42.53453586
7ZAP702.43235708
8MINK12.33217231
9MARK12.29318912
10WNK42.29037446
11KSR22.28091249
12STK392.20157797
13PAK62.19499036
14ERN12.16116482
15MAP3K42.11581255
16MAP2K32.09630832
17LMTK22.07883256
18GRK62.02809611
19JAK31.99321519
20CDK121.96295038
21TXK1.94330732
22TNK21.93275806
23PHKG21.90040502
24PHKG11.90040502
25TYK21.84238696
26BTK1.83794067
27IKBKE1.79481131
28SMG11.70431345
29NTRK21.63866464
30ARAF1.59068723
31BLK1.58573241
32MAP3K121.54462093
33SYK1.52106349
34UHMK11.51720161
35DAPK21.51446098
36OXSR11.51308782
37TAOK31.49393013
38MAP2K41.48748973
39PDK31.47837413
40PDK41.47837413
41WNK11.45802918
42MAP3K21.43402225
43MAP3K141.40778077
44FGFR41.37950157
45PAK31.36681226
46EEF2K1.35723101
47CDK51.35688885
48TYRO31.33288723
49STK381.33168101
50ITK1.32769852
51CAMKK11.31783033
52GRK51.29287605
53MAP2K71.27262216
54HCK1.27120571
55SIK11.26698324
56PNCK1.25125204
57RET1.24734476
58MUSK1.23652706
59MAP3K61.22952668
60TNIK1.22869393
61SIK31.22498467
62IRAK41.16727869
63CSK1.15326109
64JAK11.13056762
65JAK21.11934741
66LCK1.05992281
67MAP3K111.04297080
68ICK1.02734045
69TBK11.02161763
70MARK21.02144153
71KSR11.01646126
72SGK4941.01465863
73SGK2231.01465863
74PINK10.98909877
75PRPF4B0.98687256
76PRKCH0.98676447
77WNK30.98183173
78NEK90.97828723
79PTK2B0.96960316
80HIPK20.96821160
81MAP3K130.96697234
82CAMK2A0.95876554
83MAPK120.95365703
84CLK10.95108903
85TAOK20.94583579
86IKBKB0.93052205
87RIPK40.92864623
88PTK60.92821113
89MAP3K100.91369291
90CDK190.89533930
91PKN20.88890792
92LYN0.86885709
93EPHB10.86208863
94BMX0.86184142
95MAP3K10.85152996
96TAOK10.85128557
97MARK30.84616011
98TESK20.84362989
99MAPK130.83892302
100SIK20.83543811
101LIMK10.82455996
102PRKCG0.81806360
103MAP2K20.81312021
104CDK140.80664951
105STK110.79622607
106NEK10.79173313
107CASK0.78421676
108CDK180.77966858
109CAMK2D0.77964830
110FGFR20.77821478
111CDK150.77598181
112LATS20.77047939
113CAMK2B0.75287247
114CSNK1G20.74785628
115FER0.74239197
116RPS6KC10.73768247
117RPS6KL10.73768247
118CSF1R0.73493584
119PDPK10.72615793
120FES0.72209412
121CAMK10.70679552
122PDK10.70379164
123MAPKAPK50.69360750
124CDC42BPA0.69004204
125TEC0.68260243
126CAMKK20.67822968
127CDK11A0.66670638
128PDGFRA0.66418066
129PKN10.65439514
130RIPK10.64574021
131FGFR30.63675632
132PIM10.63271747
133ROCK20.62187473
134PDK20.61675858
135DYRK1B0.60254380
136CDK40.59229145
137PRKCE0.59209131
138DMPK0.58937169
139MAPK110.58451936
140MAP3K70.58321879
141FGR0.57042854
142RPS6KA60.57036073
143PRKD10.56815701
144MAP3K30.56113138
145MAPK70.56096102
146MAP2K10.56003020
147CAMK2G0.55633240
148EPHA30.55607983
149RPS6KA20.54711821
150TESK10.53024409
151SGK10.51908187
152LRRK20.51565966
153CAMK1D0.51179981
154CAMK1G0.50507986
155PRKD20.49739363
156ROCK10.49179945
157KIT0.47979821
158IRAK30.46767611
159TTN0.46370883
160FYN0.45626349
161TRIB30.45260162
162GRK70.44903407
163BRD40.44124540
164STK100.43804622
165* MAPK100.42997875
166RAF10.42281117
167MAP2K60.42259294
168MAPK30.39826815
169PRKCQ0.39474369
170YES10.38726254

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.90886514
2Acute myeloid leukemia_Homo sapiens_hsa052212.56317458
3B cell receptor signaling pathway_Homo sapiens_hsa046622.56230280
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.53096067
5Primary immunodeficiency_Homo sapiens_hsa053402.46069193
6Nicotine addiction_Homo sapiens_hsa050332.37629109
7T cell receptor signaling pathway_Homo sapiens_hsa046602.34257199
8Osteoclast differentiation_Homo sapiens_hsa043802.29227308
9Circadian entrainment_Homo sapiens_hsa047132.21555634
10Olfactory transduction_Homo sapiens_hsa047402.20413080
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14102053
12Glutamatergic synapse_Homo sapiens_hsa047242.06867710
13Insulin secretion_Homo sapiens_hsa049112.06512295
14Amphetamine addiction_Homo sapiens_hsa050312.05933310
15Long-term potentiation_Homo sapiens_hsa047202.03949610
16GABAergic synapse_Homo sapiens_hsa047272.02570514
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97991165
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94948346
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.93604617
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92970962
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.92565417
22Dopaminergic synapse_Homo sapiens_hsa047281.90066427
23Morphine addiction_Homo sapiens_hsa050321.89495166
24Non-small cell lung cancer_Homo sapiens_hsa052231.88439323
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82593089
26Salivary secretion_Homo sapiens_hsa049701.81517994
27Cardiac muscle contraction_Homo sapiens_hsa042601.80603026
28Gastric acid secretion_Homo sapiens_hsa049711.72674351
29Chronic myeloid leukemia_Homo sapiens_hsa052201.72156803
30Cocaine addiction_Homo sapiens_hsa050301.70829064
31Cholinergic synapse_Homo sapiens_hsa047251.67577287
32Leishmaniasis_Homo sapiens_hsa051401.67399459
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63934160
34Taste transduction_Homo sapiens_hsa047421.63227980
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60465965
36Other glycan degradation_Homo sapiens_hsa005111.58127343
37Measles_Homo sapiens_hsa051621.56165658
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55157624
39Renin secretion_Homo sapiens_hsa049241.55002007
40Collecting duct acid secretion_Homo sapiens_hsa049661.50535476
41Serotonergic synapse_Homo sapiens_hsa047261.45822431
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42027069
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.41887332
44Calcium signaling pathway_Homo sapiens_hsa040201.39659107
45Oxytocin signaling pathway_Homo sapiens_hsa049211.39098463
46Hepatitis B_Homo sapiens_hsa051611.37476707
47Platelet activation_Homo sapiens_hsa046111.35522955
48Chemokine signaling pathway_Homo sapiens_hsa040621.35398974
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34389575
50Pancreatic cancer_Homo sapiens_hsa052121.33503850
51Long-term depression_Homo sapiens_hsa047301.32519717
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32141213
53Dilated cardiomyopathy_Homo sapiens_hsa054141.27649215
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.26916970
55GnRH signaling pathway_Homo sapiens_hsa049121.26817087
56Notch signaling pathway_Homo sapiens_hsa043301.25315809
57Hematopoietic cell lineage_Homo sapiens_hsa046401.24805207
58Gap junction_Homo sapiens_hsa045401.23000527
59Graft-versus-host disease_Homo sapiens_hsa053321.21300811
60Type II diabetes mellitus_Homo sapiens_hsa049301.19371707
61Tuberculosis_Homo sapiens_hsa051521.18005866
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16643581
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16439289
64Axon guidance_Homo sapiens_hsa043601.14683016
65Autoimmune thyroid disease_Homo sapiens_hsa053201.12381742
66Dorso-ventral axis formation_Homo sapiens_hsa043201.12065370
67Influenza A_Homo sapiens_hsa051641.12036525
68Allograft rejection_Homo sapiens_hsa053301.11415095
69cAMP signaling pathway_Homo sapiens_hsa040241.11174472
70Herpes simplex infection_Homo sapiens_hsa051681.07404633
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06649744
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06623803
73Vibrio cholerae infection_Homo sapiens_hsa051101.06392055
74Prolactin signaling pathway_Homo sapiens_hsa049171.05906046
75Estrogen signaling pathway_Homo sapiens_hsa049151.05612619
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04740789
77Hepatitis C_Homo sapiens_hsa051601.03121945
78TNF signaling pathway_Homo sapiens_hsa046681.01460933
79Vascular smooth muscle contraction_Homo sapiens_hsa042701.01163929
80Toxoplasmosis_Homo sapiens_hsa051450.97989982
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.97611396
82Pancreatic secretion_Homo sapiens_hsa049720.97522771
83Apoptosis_Homo sapiens_hsa042100.96543073
84Alzheimers disease_Homo sapiens_hsa050100.95523089
85Oxidative phosphorylation_Homo sapiens_hsa001900.95168185
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94635870
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90358449
88Glioma_Homo sapiens_hsa052140.89698753
89Antigen processing and presentation_Homo sapiens_hsa046120.89445513
90Parkinsons disease_Homo sapiens_hsa050120.89198058
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.89070424
92Malaria_Homo sapiens_hsa051440.87829752
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87232251
94ErbB signaling pathway_Homo sapiens_hsa040120.86849746
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84590196
96Staphylococcus aureus infection_Homo sapiens_hsa051500.82302797
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81708702
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80699566
99Fructose and mannose metabolism_Homo sapiens_hsa000510.79005589
100Melanogenesis_Homo sapiens_hsa049160.78607415
101Thyroid hormone synthesis_Homo sapiens_hsa049180.78267155
102Prostate cancer_Homo sapiens_hsa052150.78068718
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77982963
104Viral carcinogenesis_Homo sapiens_hsa052030.76551665
105Glucagon signaling pathway_Homo sapiens_hsa049220.76323186
106VEGF signaling pathway_Homo sapiens_hsa043700.75977964
107HTLV-I infection_Homo sapiens_hsa051660.75660191
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75123282
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74768857
110Viral myocarditis_Homo sapiens_hsa054160.74763868
111Colorectal cancer_Homo sapiens_hsa052100.74227416
112Thyroid cancer_Homo sapiens_hsa052160.73575271
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73196091
114Shigellosis_Homo sapiens_hsa051310.72255037
115Choline metabolism in cancer_Homo sapiens_hsa052310.71543781
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70930432
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.70635229
118Endocytosis_Homo sapiens_hsa041440.70267887
119Epstein-Barr virus infection_Homo sapiens_hsa051690.65799768
120Type I diabetes mellitus_Homo sapiens_hsa049400.65751320
121HIF-1 signaling pathway_Homo sapiens_hsa040660.64829693
122Inositol phosphate metabolism_Homo sapiens_hsa005620.64305036
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.64199742
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63573809
125Butanoate metabolism_Homo sapiens_hsa006500.62407379
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61906430
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61109621
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.58473866
129Insulin signaling pathway_Homo sapiens_hsa049100.56961151
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56871291
131Oocyte meiosis_Homo sapiens_hsa041140.56108277
132MAPK signaling pathway_Homo sapiens_hsa040100.55834801
133FoxO signaling pathway_Homo sapiens_hsa040680.54785195
134Bile secretion_Homo sapiens_hsa049760.52986912
135Insulin resistance_Homo sapiens_hsa049310.52572827
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51618206
137Pyruvate metabolism_Homo sapiens_hsa006200.51294306
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50166875
139N-Glycan biosynthesis_Homo sapiens_hsa005100.50137605
140Ras signaling pathway_Homo sapiens_hsa040140.49971425
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.49735616
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.49721173
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49478885
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.48947839
145Phototransduction_Homo sapiens_hsa047440.48572780
146Propanoate metabolism_Homo sapiens_hsa006400.48145329
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48014935
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46400482
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46293330
150African trypanosomiasis_Homo sapiens_hsa051430.46265881
151Renal cell carcinoma_Homo sapiens_hsa052110.45678614
152ABC transporters_Homo sapiens_hsa020100.44937322
153Huntingtons disease_Homo sapiens_hsa050160.44831961
154Prion diseases_Homo sapiens_hsa050200.44057361
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43992907
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43622383
157Rap1 signaling pathway_Homo sapiens_hsa040150.42883298
158Fatty acid elongation_Homo sapiens_hsa000620.42625560
159Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42506204
160Fatty acid metabolism_Homo sapiens_hsa012120.40242770
161Tight junction_Homo sapiens_hsa045300.39029108
162Ovarian steroidogenesis_Homo sapiens_hsa049130.37351079
163mTOR signaling pathway_Homo sapiens_hsa041500.36700256
164Endometrial cancer_Homo sapiens_hsa052130.35525511
165Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34632428
166Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34510063
167AMPK signaling pathway_Homo sapiens_hsa041520.33935710

Most similar genes based on co-expression Upload to Enrichr

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