USP19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)4.29584409
2peptidyl-lysine dimethylation (GO:0018027)4.12542341
3negative regulation of cell size (GO:0045792)3.83800269
43-UTR-mediated mRNA stabilization (GO:0070935)3.70808230
5pre-miRNA processing (GO:0031054)3.65899510
6cytoplasmic mRNA processing body assembly (GO:0033962)3.48545618
7plasma membrane repair (GO:0001778)3.40147046
8negative regulation of cell killing (GO:0031342)3.39095035
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39095035
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.17432011
11regulation of fatty acid beta-oxidation (GO:0031998)3.16429084
12response to muramyl dipeptide (GO:0032495)3.13793441
13adherens junction assembly (GO:0034333)3.13448224
14regulation of gamma-delta T cell differentiation (GO:0045586)3.12275099
15response to laminar fluid shear stress (GO:0034616)3.11544258
16antigen processing and presentation of endogenous antigen (GO:0019883)3.09017504
17regulation of hippo signaling (GO:0035330)3.07331932
18heterochromatin organization (GO:0070828)3.07049493
19negative regulation of erythrocyte differentiation (GO:0045647)3.06255184
20embryonic process involved in female pregnancy (GO:0060136)3.02619405
21cell-substrate adherens junction assembly (GO:0007045)3.01054728
22focal adhesion assembly (GO:0048041)3.01054728
23histone H3-K9 demethylation (GO:0033169)2.99751239
24positive thymic T cell selection (GO:0045059)2.96672734
25NLS-bearing protein import into nucleus (GO:0006607)2.94643822
26carnitine shuttle (GO:0006853)2.93011977
27positive regulation by symbiont of host defense response (GO:0052509)2.92047961
28modulation by symbiont of host defense response (GO:0052031)2.92047961
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92047961
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92047961
31positive regulation by organism of defense response of other organism involved in symbiotic interact2.92047961
32modulation by symbiont of host immune response (GO:0052553)2.92047961
33retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.90260296
34negative regulation of histone methylation (GO:0031061)2.89966339
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.88572958
36negative regulation of myotube differentiation (GO:0010832)2.88079360
37positive regulation of protein deacetylation (GO:0090312)2.87718282
38cell-substrate junction assembly (GO:0007044)2.86351733
39histone H3-K36 demethylation (GO:0070544)2.84899967
40growth hormone receptor signaling pathway (GO:0060396)2.84785432
41negative regulation of fatty acid transport (GO:2000192)2.84230933
42insulin-like growth factor receptor signaling pathway (GO:0048009)2.83518102
43germinal center formation (GO:0002467)2.83517497
44sodium ion export (GO:0071436)2.82933542
45positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82630645
46regulation of cholesterol homeostasis (GO:2000188)2.82315266
47regulation of ARF protein signal transduction (GO:0032012)2.82015121
48apoptotic cell clearance (GO:0043277)2.81578824
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.80167736
50regulation of chromatin binding (GO:0035561)2.79964353
51regulation of early endosome to late endosome transport (GO:2000641)2.79385802
52negative regulation of necroptotic process (GO:0060546)2.79355311
53barbed-end actin filament capping (GO:0051016)2.78362323
54regulation of necroptotic process (GO:0060544)2.77925593
55negative regulation of potassium ion transmembrane transport (GO:1901380)2.76647803
56positive regulation of nuclease activity (GO:0032075)2.76198722
57cellular response to growth hormone stimulus (GO:0071378)2.76020297
58intracellular estrogen receptor signaling pathway (GO:0030520)2.73928370
59mRNA stabilization (GO:0048255)2.73808435
60RNA stabilization (GO:0043489)2.73808435
61cardiac myofibril assembly (GO:0055003)2.73463054
62regulation of p38MAPK cascade (GO:1900744)2.73278160
63regulation of translational termination (GO:0006449)2.72726320
64gene silencing (GO:0016458)2.71972703
65gene silencing by RNA (GO:0031047)2.71102746
66detection of other organism (GO:0098543)2.69685755
67macroautophagy (GO:0016236)2.69473207
68spliceosomal tri-snRNP complex assembly (GO:0000244)2.69262659
69positive regulation of myotube differentiation (GO:0010831)2.69125105
70regulation of gamma-delta T cell activation (GO:0046643)2.68970368
71regulation of NFAT protein import into nucleus (GO:0051532)2.68691146
72regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67261690
73regulation of histone H3-K27 methylation (GO:0061085)2.66940340
74glucocorticoid receptor signaling pathway (GO:0042921)2.65622972
75regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64409348
76response to peptidoglycan (GO:0032494)2.63733053
77detection of bacterium (GO:0016045)2.63697980
78positive regulation of RNA splicing (GO:0033120)2.63381823
79NIK/NF-kappaB signaling (GO:0038061)2.62882380
80mannose metabolic process (GO:0006013)2.62642197
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62542548
82epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62128046
83mitotic G1 DNA damage checkpoint (GO:0031571)2.60389720
84negative regulation of toll-like receptor signaling pathway (GO:0034122)2.60098980
85regulation of glucose import in response to insulin stimulus (GO:2001273)2.59935594
86maternal placenta development (GO:0001893)2.58865328
87negative regulation of heart growth (GO:0061117)2.57323864
88negative regulation of cardiac muscle tissue growth (GO:0055022)2.57323864
89nuclear pore complex assembly (GO:0051292)2.56880193
90fatty acid transmembrane transport (GO:1902001)2.56714155
91regulation of nucleobase-containing compound transport (GO:0032239)2.54508327
92modulation by symbiont of host cellular process (GO:0044068)2.54385311
93regulation of cholesterol storage (GO:0010885)2.54170706
94synaptonemal complex assembly (GO:0007130)2.53868199
95histone H4 deacetylation (GO:0070933)2.53141782
96negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.52124119
97activation of Rac GTPase activity (GO:0032863)2.51365803
98stress fiber assembly (GO:0043149)2.51360692
99positive regulation of gamma-delta T cell activation (GO:0046645)2.51262073
100cellular hyperosmotic response (GO:0071474)2.50633557
101antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49285197
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49285197
103positive regulation of fatty acid beta-oxidation (GO:0032000)2.48990350
104pinocytosis (GO:0006907)2.48349804
105regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.48127604
106proline biosynthetic process (GO:0006561)2.47315615
107regulation of nuclease activity (GO:0032069)2.46840918
108pentose-phosphate shunt (GO:0006098)2.46582429
109macrophage activation involved in immune response (GO:0002281)2.46416910
110regulation of fatty acid oxidation (GO:0046320)2.43635098
111natural killer cell differentiation (GO:0001779)2.42202069
112protein localization to endosome (GO:0036010)2.42071758
113tricarboxylic acid metabolic process (GO:0072350)2.41777359
114positive regulation of triglyceride biosynthetic process (GO:0010867)2.41417794
115creatine metabolic process (GO:0006600)2.41072932
116regulation of RNA export from nucleus (GO:0046831)2.40350427
117fibroblast migration (GO:0010761)2.40041615
1182-oxoglutarate metabolic process (GO:0006103)2.39636481
119positive regulation of glycogen biosynthetic process (GO:0045725)2.39277041
120histone H2A monoubiquitination (GO:0035518)2.39140419
121Golgi transport vesicle coating (GO:0048200)2.38997014
122COPI coating of Golgi vesicle (GO:0048205)2.38997014
123T cell selection (GO:0045058)2.38518557
124cellular extravasation (GO:0045123)2.38369228
125histone lysine demethylation (GO:0070076)2.37405561
126positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37162670
127modulation by virus of host process (GO:0019054)2.37072543
128negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.36974963
129negative thymic T cell selection (GO:0045060)2.36666173
130positive regulation of p38MAPK cascade (GO:1900745)2.36618142
131L-alpha-amino acid transmembrane transport (GO:1902475)2.35084807
132cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.34993215
133negative regulation of viral release from host cell (GO:1902187)2.34874112
134regulation of translational fidelity (GO:0006450)2.34582956
135positive regulation of gene expression, epigenetic (GO:0045815)2.34438313
136endoplasmic reticulum unfolded protein response (GO:0030968)2.34146238
137regulation of ARF GTPase activity (GO:0032312)2.33972266
138NADH metabolic process (GO:0006734)2.33702865
139stress granule assembly (GO:0034063)2.33633009
140signal complex assembly (GO:0007172)2.33047524
141positive regulation of Cdc42 GTPase activity (GO:0043089)2.32931791
142dosage compensation (GO:0007549)2.32322960
143regulation of leukocyte degranulation (GO:0043300)2.31558972
144B cell receptor signaling pathway (GO:0050853)2.30801500
145carnitine transmembrane transport (GO:1902603)2.30332648
146detection of external biotic stimulus (GO:0098581)2.30207590
147negative regulation of nucleotide catabolic process (GO:0030812)2.30078744
148negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.29878870
149histone H4-K16 acetylation (GO:0043984)2.29826017
150epithelial cell-cell adhesion (GO:0090136)2.29769395
151low-density lipoprotein particle clearance (GO:0034383)2.29515485
152sarcomere organization (GO:0045214)2.29328754
153positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.29277539
154glial cell proliferation (GO:0014009)2.28616314
155histone demethylation (GO:0016577)2.28233133
156nuclear pore organization (GO:0006999)2.28007497
157positive regulation of receptor recycling (GO:0001921)2.27967447
158positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.27150748
159thymic T cell selection (GO:0045061)2.26990488
160myofibril assembly (GO:0030239)2.26556982
161activation of JUN kinase activity (GO:0007257)2.26345631
162apoptotic process involved in morphogenesis (GO:0060561)2.25798031
163regulation of mammary gland epithelial cell proliferation (GO:0033599)2.25197082
164cellular response to epidermal growth factor stimulus (GO:0071364)2.24133187
165regulation of defense response to virus by virus (GO:0050690)2.21190568
166positive T cell selection (GO:0043368)2.20839688
167antigen processing and presentation via MHC class Ib (GO:0002475)2.19247058
168positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.18796918
169cortical actin cytoskeleton organization (GO:0030866)2.18348610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.77793659
2MYC_22102868_ChIP-Seq_BL_Human3.37563187
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.04546951
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94181942
5KDM2B_26808549_Chip-Seq_DND41_Human2.65205866
6TCF7_22412390_ChIP-Seq_EML_Mouse2.64723232
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56508746
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37858006
9KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.34283850
10* FOXM1_23109430_ChIP-Seq_U2OS_Human2.31834696
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29399650
12VDR_21846776_ChIP-Seq_THP-1_Human2.23674661
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.07992365
14ZNF263_19887448_ChIP-Seq_K562_Human2.07468219
15CLOCK_20551151_ChIP-Seq_293T_Human2.01125234
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00667341
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96391444
18* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94219480
19LXR_22292898_ChIP-Seq_THP-1_Human1.93964811
20KDM2B_26808549_Chip-Seq_K562_Human1.90718214
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87412184
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86456863
23KDM2B_26808549_Chip-Seq_JURKAT_Human1.83434382
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.81693075
25DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77204526
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76203931
27RACK7_27058665_Chip-Seq_MCF-7_Human1.75091789
28UTX_26944678_Chip-Seq_JUKART_Human1.70788167
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66536963
30MAF_26560356_Chip-Seq_TH1_Human1.65063349
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64063917
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.61993964
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58847859
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55240828
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.55047760
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52201196
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51650056
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51331966
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51305028
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50960873
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50437698
42NCOR1_26117541_ChIP-Seq_K562_Human1.49862590
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48979282
44ATF3_27146783_Chip-Seq_COLON_Human1.48382956
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46773469
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.46053311
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.46053311
48CREB1_26743006_Chip-Seq_LNCaP_Human1.45494159
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44826814
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44657730
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44200368
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44059889
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40900892
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39248517
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.38802100
56E2F7_22180533_ChIP-Seq_HELA_Human1.38103225
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38045768
58P68_20966046_ChIP-Seq_HELA_Human1.37293037
59FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.35919827
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.35882896
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35310687
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33838874
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32098362
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31418887
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31142836
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27200012
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27187605
68CIITA_25753668_ChIP-Seq_RAJI_Human1.26067835
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24736267
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23178786
71GATA1_19941826_ChIP-Seq_K562_Human1.22716170
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22440681
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22192855
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.22092539
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21647394
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.21521430
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20337294
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19485458
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.18578338
80TP53_22127205_ChIP-Seq_IMR90_Human1.18277938
81TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17681377
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17494593
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.16159458
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15551991
85* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15505379
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14228951
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.13934307
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13422778
89VDR_24763502_ChIP-Seq_THP-1_Human1.12376935
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12139383
91SMC4_20622854_ChIP-Seq_HELA_Human1.11636606
92SPI1_23127762_ChIP-Seq_K562_Human1.11579689
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.09645737
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.09168880
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.09132537
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08911491
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08076363
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07848170
99* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07521061
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06943385
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06771704
102SCL_19346495_ChIP-Seq_HPC-7_Human1.06137562
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05981593
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05788425
105MAF_26560356_Chip-Seq_TH2_Human1.05390110
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04764018
107MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04524362
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03924725
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03822553
110* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02556003
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.02451910
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01385849
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.00880406
114GATA1_22025678_ChIP-Seq_K562_Human1.00613312
115GATA6_25053715_ChIP-Seq_YYC3_Human0.99803593
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99404957
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99043793
118* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97878938
119IRF8_22096565_ChIP-ChIP_GC-B_Human0.97771960
120MYB_26560356_Chip-Seq_TH1_Human0.97636650
121CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97557676
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96332317
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95807201
124BCOR_27268052_Chip-Seq_Bcells_Human0.95011872
125SA1_27219007_Chip-Seq_ERYTHROID_Human0.93247497
126TP63_22573176_ChIP-Seq_HFKS_Human0.93073605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.18112405
2MP0003705_abnormal_hypodermis_morpholog3.96934514
3MP0005058_abnormal_lysosome_morphology2.71161463
4MP0005076_abnormal_cell_differentiation2.66840498
5MP0003436_decreased_susceptibility_to2.61121670
6MP0003300_gastrointestinal_ulcer2.60770702
7MP0010352_gastrointestinal_tract_polyps2.60503723
8MP0008961_abnormal_basal_metabolism2.51310460
9MP0008260_abnormal_autophagy2.51155563
10MP0009278_abnormal_bone_marrow2.39526671
11MP0000751_myopathy2.37970369
12MP0004084_abnormal_cardiac_muscle2.27621378
13MP0005670_abnormal_white_adipose2.19985316
14MP0003566_abnormal_cell_adhesion2.13736557
15MP0004185_abnormal_adipocyte_glucose2.08380958
16MP0000569_abnormal_digit_pigmentation2.04342626
17MP0003172_abnormal_lysosome_physiology2.03923147
18MP0004130_abnormal_muscle_cell2.00454276
19MP0000733_abnormal_muscle_development1.95844416
20MP0005666_abnormal_adipose_tissue1.94952780
21MP0003763_abnormal_thymus_physiology1.94078609
22MP0004087_abnormal_muscle_fiber1.91564559
23MP0010234_abnormal_vibrissa_follicle1.89123980
24MP0003646_muscle_fatigue1.88237994
25MP0003045_fibrosis1.85217131
26MP0002877_abnormal_melanocyte_morpholog1.80049952
27MP0010630_abnormal_cardiac_muscle1.74473901
28MP0010307_abnormal_tumor_latency1.70218854
29MP0005409_darkened_coat_color1.66097648
30MP0001849_ear_inflammation1.65303513
31MP0005375_adipose_tissue_phenotype1.64840956
32MP0002269_muscular_atrophy1.61040349
33MP0004510_myositis1.59350392
34MP0004036_abnormal_muscle_relaxation1.58632275
35MP0002396_abnormal_hematopoietic_system1.52182528
36MP0004233_abnormal_muscle_weight1.48396603
37MP0004808_abnormal_hematopoietic_stem1.42113764
38MP0003828_pulmonary_edema1.41368384
39MP0000750_abnormal_muscle_regeneration1.41354574
40MP0003453_abnormal_keratinocyte_physiol1.41337889
41MP0002419_abnormal_innate_immunity1.39807220
42MP0000003_abnormal_adipose_tissue1.37587532
43MP0002009_preneoplasia1.37062592
44MP0008438_abnormal_cutaneous_collagen1.36760489
45MP0003283_abnormal_digestive_organ1.36320780
46MP0000858_altered_metastatic_potential1.34256219
47MP0002653_abnormal_ependyma_morphology1.34096340
48MP0000747_muscle_weakness1.33354227
49MP0001835_abnormal_antigen_presentation1.32067757
50MP0002106_abnormal_muscle_physiology1.31592726
51MP0008877_abnormal_DNA_methylation1.31257348
52MP0005025_abnormal_response_to1.30715902
53MP0001348_abnormal_lacrimal_gland1.30139420
54MP0003303_peritoneal_inflammation1.28040292
55MP0009333_abnormal_splenocyte_physiolog1.27988146
56MP0005000_abnormal_immune_tolerance1.24133816
57MP0004197_abnormal_fetal_growth/weight/1.23017035
58MP0003329_amyloid_beta_deposits1.22866269
59MP0002837_dystrophic_cardiac_calcinosis1.22780732
60MP0005330_cardiomyopathy1.22677768
61MP0000759_abnormal_skeletal_muscle1.20734486
62MP0005623_abnormal_meninges_morphology1.20554760
63MP0004381_abnormal_hair_follicle1.18684340
64MP0008995_early_reproductive_senescence1.14862517
65MP0001800_abnormal_humoral_immune1.14279916
66MP0003878_abnormal_ear_physiology1.14223497
67MP0005377_hearing/vestibular/ear_phenot1.14223497
68MP0003091_abnormal_cell_migration1.13113300
69MP0005387_immune_system_phenotype1.12589357
70MP0001790_abnormal_immune_system1.12589357
71MP0002398_abnormal_bone_marrow1.12085210
72MP0002909_abnormal_adrenal_gland1.11932133
73MP0002998_abnormal_bone_remodeling1.11563166
74MP0000703_abnormal_thymus_morphology1.10705446
75MP0000749_muscle_degeneration1.10329834
76MP0003252_abnormal_bile_duct1.10310127
77MP0003115_abnormal_respiratory_system1.10162741
78MP0003656_abnormal_erythrocyte_physiolo1.09040753
79MP0001545_abnormal_hematopoietic_system1.08898475
80MP0005397_hematopoietic_system_phenotyp1.08898475
81MP0009672_abnormal_birth_weight1.08492226
82MP0001730_embryonic_growth_arrest1.08170537
83MP0002088_abnormal_embryonic_growth/wei1.07927388
84MP0003984_embryonic_growth_retardation1.07740368
85MP0000266_abnormal_heart_morphology1.07573406
86MP0005023_abnormal_wound_healing1.07411360
87MP0003724_increased_susceptibility_to1.06623518
88MP0002420_abnormal_adaptive_immunity1.06471414
89MP0001819_abnormal_immune_cell1.05799061
90MP0003279_aneurysm1.05341156
91MP0002086_abnormal_extraembryonic_tissu1.04185429
92MP0005464_abnormal_platelet_physiology1.03990899
93MP0006138_congestive_heart_failure1.03343002
94MP0001672_abnormal_embryogenesis/_devel1.02805839
95MP0005380_embryogenesis_phenotype1.02805839
96MP0004145_abnormal_muscle_electrophysio1.02595705
97MP0003191_abnormal_cellular_cholesterol1.02217185
98MP0001533_abnormal_skeleton_physiology1.02097093
99MP0002723_abnormal_immune_serum1.01408168
100MP0002452_abnormal_antigen_presenting0.99710764
101MP0000537_abnormal_urethra_morphology0.98277071
102MP0002925_abnormal_cardiovascular_devel0.98236878
103MP0005621_abnormal_cell_physiology0.97527386
104MP0002084_abnormal_developmental_patter0.96105064
105MP0005369_muscle_phenotype0.95520354
106MP0002332_abnormal_exercise_endurance0.94076274
107MP0010155_abnormal_intestine_physiology0.93680622
108MP0001544_abnormal_cardiovascular_syste0.92684404
109MP0005385_cardiovascular_system_phenoty0.92684404
110MP0002722_abnormal_immune_system0.92599060
111MP0001915_intracranial_hemorrhage0.92427303
112MP0004858_abnormal_nervous_system0.92202322
113MP0000716_abnormal_immune_system0.91693348
114MP0003183_abnormal_peptide_metabolism0.91479798
115MP0009840_abnormal_foam_cell0.91415301
116MP0002405_respiratory_system_inflammati0.89483132
117MP0003690_abnormal_glial_cell0.89142854
118MP0000678_abnormal_parathyroid_gland0.88969791
119MP0005275_abnormal_skin_tensile0.87839291
120MP0003111_abnormal_nucleus_morphology0.86613861
121MP0001851_eye_inflammation0.86093082
122MP0002429_abnormal_blood_cell0.84801245
123MP0004947_skin_inflammation0.84706881
124MP0002971_abnormal_brown_adipose0.84351413
125MP0000609_abnormal_liver_physiology0.83915536
126MP0002089_abnormal_postnatal_growth/wei0.81285769
127MP0001958_emphysema0.81282291
128MP0009780_abnormal_chondrocyte_physiolo0.80321859
129MP0000350_abnormal_cell_proliferation0.80197272
130MP0005620_abnormal_muscle_contractility0.79738938
131MP0002796_impaired_skin_barrier0.79734631
132MP0000604_amyloidosis0.79639305
133MP0008770_decreased_survivor_rate0.79606397
134MP0000428_abnormal_craniofacial_morphol0.79456919
135MP0002928_abnormal_bile_duct0.78898291
136MP0004264_abnormal_extraembryonic_tissu0.78822236
137MP0002080_prenatal_lethality0.78754667
138MP0002234_abnormal_pharynx_morphology0.78343708
139MP0000685_abnormal_immune_system0.78306398
140MP0002085_abnormal_embryonic_tissue0.78197712
141MP0002166_altered_tumor_susceptibility0.77792103
142MP0000371_diluted_coat_color0.77718735
143MP0003787_abnormal_imprinting0.76820068
144MP0002128_abnormal_blood_circulation0.76724672
145MP0008775_abnormal_heart_ventricle0.76207023
146MP0003221_abnormal_cardiomyocyte_apopto0.76131303
147MP0009703_decreased_birth_body0.76052977
148MP0001697_abnormal_embryo_size0.75972740
149MP0003075_altered_response_to0.75351613
150MP0003567_abnormal_fetal_cardiomyocyte0.74303109
151MP0000689_abnormal_spleen_morphology0.73989973
152MP0005671_abnormal_response_to0.71285361
153MP0000490_abnormal_crypts_of0.70680904

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.97912958
2Hyperacusis (HP:0010780)3.73191672
3Centrally nucleated skeletal muscle fibers (HP:0003687)3.43344569
4Eczematoid dermatitis (HP:0000976)3.13963600
5Upper limb amyotrophy (HP:0009129)3.13589743
6Distal upper limb amyotrophy (HP:0007149)3.13589743
7Difficulty running (HP:0009046)3.12798202
8Increased connective tissue (HP:0009025)3.04665055
9Hand muscle atrophy (HP:0009130)3.03822437
10Abnormality of the lower motor neuron (HP:0002366)2.98032533
11Hyporeflexia of lower limbs (HP:0002600)2.96533420
12Enlarged penis (HP:0000040)2.86190831
13Elfin facies (HP:0004428)2.80859340
14Macroorchidism (HP:0000053)2.79572801
15Aneurysm (HP:0002617)2.73898256
16Ankle contracture (HP:0006466)2.70054491
17Broad face (HP:0000283)2.69273196
18Renovascular hypertension (HP:0100817)2.67797252
19Abnormality of the fingertips (HP:0001211)2.67046800
20Dysmetric saccades (HP:0000641)2.66550456
21Difficulty climbing stairs (HP:0003551)2.60417213
22Exercise-induced myalgia (HP:0003738)2.59831033
23Obstructive sleep apnea (HP:0002870)2.59486859
24Shallow orbits (HP:0000586)2.58825787
25Aortic aneurysm (HP:0004942)2.58417764
26Type 1 muscle fiber predominance (HP:0003803)2.57951263
27Distal lower limb muscle weakness (HP:0009053)2.53421885
28Broad metatarsal (HP:0001783)2.51782417
29Bundle branch block (HP:0011710)2.50006479
30Muscle fiber inclusion bodies (HP:0100299)2.43125328
31Insomnia (HP:0100785)2.40069028
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.36238863
33Long toe (HP:0010511)2.33396471
34Cellulitis (HP:0100658)2.33128128
35Nemaline bodies (HP:0003798)2.31203503
36Heterotopia (HP:0002282)2.30814043
37Protrusio acetabuli (HP:0003179)2.30680195
38Exercise-induced muscle cramps (HP:0003710)2.27840355
39Colitis (HP:0002583)2.27743028
40Lymphangioma (HP:0100764)2.27578191
41Asymmetric septal hypertrophy (HP:0001670)2.26763300
42Bladder diverticulum (HP:0000015)2.25441290
43Bowel diverticulosis (HP:0005222)2.24777919
44Ependymoma (HP:0002888)2.23014754
45Vertebral compression fractures (HP:0002953)2.22243878
46Facial diplegia (HP:0001349)2.22226885
47Renal duplication (HP:0000075)2.20498431
48Rectal prolapse (HP:0002035)2.18738955
49EMG: neuropathic changes (HP:0003445)2.17462730
50Frequent falls (HP:0002359)2.15812135
51Mitral valve prolapse (HP:0001634)2.15501087
52Muscle fiber splitting (HP:0003555)2.10997957
53Flat acetabular roof (HP:0003180)2.10661153
54Increased variability in muscle fiber diameter (HP:0003557)2.09613727
55Myoglobinuria (HP:0002913)2.09576891
56Sudden death (HP:0001699)2.09211239
57Right ventricular cardiomyopathy (HP:0011663)2.07381339
58Male infertility (HP:0003251)2.04023070
59Pointed chin (HP:0000307)2.03955371
60Back pain (HP:0003418)2.03889077
61Abnormality of the left ventricular outflow tract (HP:0011103)2.01954942
62Subaortic stenosis (HP:0001682)2.01954942
63EMG: myopathic abnormalities (HP:0003458)2.00980223
64Abnormality of the astrocytes (HP:0100707)1.99320315
65Astrocytoma (HP:0009592)1.99320315
66Ulnar bowing (HP:0003031)1.99294830
67Atrioventricular block (HP:0001678)1.98782093
68Overriding aorta (HP:0002623)1.98745305
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98653205
70Gingivitis (HP:0000230)1.98639118
71Pseudobulbar signs (HP:0002200)1.97772571
72Increased IgE level (HP:0003212)1.96264967
73Mildly elevated creatine phosphokinase (HP:0008180)1.95153848
74Flat cornea (HP:0007720)1.95152326
75Fatigue (HP:0012378)1.94865043
76Recurrent abscess formation (HP:0002722)1.94751288
77Abnormality of skeletal muscle fiber size (HP:0012084)1.94692156
78Neoplasm of the heart (HP:0100544)1.92275551
79Abnormality of the Achilles tendon (HP:0005109)1.91111137
80Striae distensae (HP:0001065)1.90385871
81Dilatation of the ascending aorta (HP:0005111)1.89928929
82Gastrointestinal inflammation (HP:0004386)1.88529540
83Hemorrhage of the eye (HP:0011885)1.88488737
84Ventricular tachycardia (HP:0004756)1.88224620
85Segmental peripheral demyelination/remyelination (HP:0003481)1.87690068
86Scapular winging (HP:0003691)1.87577877
87Recurrent bacterial skin infections (HP:0005406)1.86286160
88Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85948218
89Reticulocytosis (HP:0001923)1.84072668
90Metaphyseal cupping (HP:0003021)1.82828105
91Abnormality of macrophages (HP:0004311)1.82733310
92Round ear (HP:0100830)1.82098761
93High pitched voice (HP:0001620)1.82051054
94Short 4th metacarpal (HP:0010044)1.81450198
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81450198
96Subacute progressive viral hepatitis (HP:0006572)1.81380992
97Ulnar deviation of the wrist (HP:0003049)1.81244435
98Abnormality of the thoracic spine (HP:0100711)1.81084089
99Interstitial pulmonary disease (HP:0006530)1.80263249
100Long palpebral fissure (HP:0000637)1.80199638
101Increased density of long bones (HP:0006392)1.80180098
102Abnormality of the 4th metacarpal (HP:0010012)1.79846478
103Ragged-red muscle fibers (HP:0003200)1.79079086
104Rhabdomyolysis (HP:0003201)1.78531383
105Gastrointestinal infarctions (HP:0005244)1.77920952
106Gastrointestinal stroma tumor (HP:0100723)1.77885131
107Dislocated radial head (HP:0003083)1.77850063
108Narrow palate (HP:0000189)1.76744127
109Foot dorsiflexor weakness (HP:0009027)1.76245013
110Slow saccadic eye movements (HP:0000514)1.76175760
111Hypercortisolism (HP:0001578)1.76095621
112Vertebral arch anomaly (HP:0008438)1.73057312
113Genu recurvatum (HP:0002816)1.72149090
114Myopathic facies (HP:0002058)1.71394331
115Progressive external ophthalmoplegia (HP:0000590)1.71069412
116Heart block (HP:0012722)1.70799919
117Dysostosis multiplex (HP:0000943)1.69769448
118Increased nuchal translucency (HP:0010880)1.69564271
119Turricephaly (HP:0000262)1.69140187
120Progressive muscle weakness (HP:0003323)1.68525603
121Thin bony cortex (HP:0002753)1.67988170
122Radial bowing (HP:0002986)1.67674012
123Aortic dissection (HP:0002647)1.66921891
124Onion bulb formation (HP:0003383)1.66559042
125Spinal cord lesions (HP:0100561)1.66356548
126Syringomyelia (HP:0003396)1.66356548
127Abnormal gallbladder physiology (HP:0012438)1.65509524
128Cholecystitis (HP:0001082)1.65509524
129Long eyelashes (HP:0000527)1.65337202
130Ventricular fibrillation (HP:0001663)1.64904040
131Spinal rigidity (HP:0003306)1.63908752
132Viral hepatitis (HP:0006562)1.63905185
133Thoracic kyphosis (HP:0002942)1.63523916
134Obsessive-compulsive behavior (HP:0000722)1.63279479
135Cerebral inclusion bodies (HP:0100314)1.63171929
136Muscle stiffness (HP:0003552)1.63114973
137Recurrent gram-negative bacterial infections (HP:0005420)1.62820650
138Abnormal atrioventricular conduction (HP:0005150)1.62779895
139Hematochezia (HP:0002573)1.61565110
140Mitral regurgitation (HP:0001653)1.61376850
141Inflammation of the large intestine (HP:0002037)1.61165526
142Resting tremor (HP:0002322)1.60809631
143Chest pain (HP:0100749)1.60471975
144Polycythemia (HP:0001901)1.59724399
145Abnormality of the foot musculature (HP:0001436)1.59671044
146Germ cell neoplasia (HP:0100728)1.59541777
147Distal lower limb amyotrophy (HP:0008944)1.59415329
148Cervical subluxation (HP:0003308)1.58443109
149Abnormality of the calcaneus (HP:0008364)1.58344837
150Stridor (HP:0010307)1.58203202
151Proximal amyotrophy (HP:0007126)1.58070114
152Abnormality of the radial head (HP:0003995)1.57736959
153Bulbar palsy (HP:0001283)1.57711303
154Disproportionate tall stature (HP:0001519)1.57602665
155Decreased motor nerve conduction velocity (HP:0003431)1.57034560
156Mediastinal lymphadenopathy (HP:0100721)1.56757665
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.56567978
158Broad palm (HP:0001169)1.56472398
159Myositis (HP:0100614)1.56382901
160Fibroma (HP:0010614)1.55464946
161Deep palmar crease (HP:0006191)1.55348139
162Hallux valgus (HP:0001822)1.54969138
163Achilles tendon contracture (HP:0001771)1.54480469
164Lower limb amyotrophy (HP:0007210)1.54322535
165Deviation of the hallux (HP:0010051)1.54073934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.92866496
2PRPF4B3.87424925
3PKN23.80608002
4EEF2K3.65989822
5SMG13.35407367
6CDK123.25522176
7MAP3K102.97329134
8TTN2.92368947
9RIPK12.55573453
10ERN12.35968642
11PTK62.06326854
12SIK12.06250246
13RIPK42.00300834
14LATS11.98914437
15PDGFRA1.89997133
16ICK1.87595692
17IRAK31.78435047
18MAP3K131.59649103
19CAMK1D1.56331839
20PRKD31.53099272
21FGFR41.44931865
22CAMK1G1.42795698
23MTOR1.42623951
24TYRO31.38691483
25TAOK11.38316227
26MAP3K141.28535235
27NEK21.26580926
28EPHB11.25064537
29ALK1.19089791
30MAP3K71.18086615
31LMTK21.14032902
32DMPK1.12338539
33IRAK41.11060998
34TAOK21.10667434
35BRD41.10100012
36MAP4K11.08317371
37PAK41.07984831
38SIK21.07133542
39FLT31.04990908
40MAP2K31.02686487
41BMX1.02616969
42MAP3K61.01737261
43MAPK120.99502006
44STK380.98809390
45RET0.98209223
46KSR20.98137259
47MAPKAPK30.97842542
48CDK40.96469030
49FGFR30.96102520
50LATS20.94204887
51BLK0.93595846
52LRRK20.92424001
53TBK10.91553968
54PDPK10.88473604
55PTK20.87265440
56JAK10.86672874
57SCYL20.86599605
58PDK40.86519447
59PDK30.86519447
60PDGFRB0.86347277
61NEK10.85461522
62IRAK20.84177627
63CDK60.82951500
64STK100.81365302
65CDC42BPA0.80832745
66SIK30.80732879
67RPS6KB20.80250459
68PAK20.79225896
69PRKCH0.77946707
70MAP3K110.77166091
71CAMKK10.75757678
72STK30.73736705
73PAK60.72972289
74SGK30.71271496
75TNK20.70614646
76RPS6KL10.70453254
77RPS6KC10.70453254
78OBSCN0.70077647
79CDK90.69744584
80TESK20.67504161
81JAK30.65259616
82BTK0.63967363
83NME20.62502776
84TAOK30.62176057
85TYK20.62157878
86JAK20.61555503
87FES0.59402946
88DDR20.58597629
89RAF10.57418929
90PHKG20.57114000
91PHKG10.57114000
92MAPK70.56649767
93PASK0.55229621
94MAP2K20.55218919
95MARK20.54880046
96EPHA20.54587742
97ARAF0.53454446
98PRKD20.52957086
99MAP3K80.52666663
100PRKAA10.52377051
101DYRK1B0.51385503
102FGFR10.50011694
103MAPK110.49864922
104CHUK0.49448909
105MAP3K90.49119260
106PRKD10.48640371
107TGFBR20.48590318
108WNK10.47446178
109NEK90.47125855
110PRKAA20.45732316
111RPS6KA60.45723453
112FGR0.43911833
113BRAF0.43159646
114ZAP700.42820305
115DAPK20.42648705
116AKT20.42453872
117RPS6KA20.41734976
118MOS0.41374797
119CSK0.40977976
120GRK60.40507791
121HCK0.40198317
122RPS6KA10.39034443
123PDK10.38807489
124KSR10.38732090
125MAP3K10.38054528
126CHEK10.37539899
127IRAK10.36993995
128STK40.36844409
129CAMK40.36697803
130MST1R0.35985525
131CDC70.35158956
132IKBKE0.34699714
133BCKDK0.33802438
134HIPK20.33244044
135MARK30.33150252
136MAP3K30.32458363
137MAPK80.32280541
138MAP3K20.31496456
139MAPK10.30708295

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31630148
2Other glycan degradation_Homo sapiens_hsa005112.28134718
3Lysine degradation_Homo sapiens_hsa003102.22287253
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78336218
5mTOR signaling pathway_Homo sapiens_hsa041501.75526236
6Insulin resistance_Homo sapiens_hsa049311.73248027
7Chronic myeloid leukemia_Homo sapiens_hsa052201.71349097
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69293041
9Nitrogen metabolism_Homo sapiens_hsa009101.52507252
10Notch signaling pathway_Homo sapiens_hsa043301.47514450
11Dorso-ventral axis formation_Homo sapiens_hsa043201.45886987
12Adipocytokine signaling pathway_Homo sapiens_hsa049201.44471301
13Thyroid hormone signaling pathway_Homo sapiens_hsa049191.43473775
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41620544
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.39561657
16Longevity regulating pathway - mammal_Homo sapiens_hsa042111.37907975
17Type II diabetes mellitus_Homo sapiens_hsa049301.36271611
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34054068
19Small cell lung cancer_Homo sapiens_hsa052221.30895019
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30570849
21Insulin signaling pathway_Homo sapiens_hsa049101.29382186
22Pentose phosphate pathway_Homo sapiens_hsa000301.28845006
23Dilated cardiomyopathy_Homo sapiens_hsa054141.28777364
24Focal adhesion_Homo sapiens_hsa045101.28069249
25Leishmaniasis_Homo sapiens_hsa051401.24611506
26Non-small cell lung cancer_Homo sapiens_hsa052231.23217434
27Acute myeloid leukemia_Homo sapiens_hsa052211.22498312
28Glucagon signaling pathway_Homo sapiens_hsa049221.20864430
29Endometrial cancer_Homo sapiens_hsa052131.20358693
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19165354
31AMPK signaling pathway_Homo sapiens_hsa041521.19062584
32Proteoglycans in cancer_Homo sapiens_hsa052051.17421230
33Adherens junction_Homo sapiens_hsa045201.13472814
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11838514
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11575296
36Hepatitis C_Homo sapiens_hsa051601.10377397
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.09081830
38Prion diseases_Homo sapiens_hsa050201.08131942
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07960141
40VEGF signaling pathway_Homo sapiens_hsa043701.06196822
41Glioma_Homo sapiens_hsa052141.05431915
42Viral myocarditis_Homo sapiens_hsa054161.04926077
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03967849
44B cell receptor signaling pathway_Homo sapiens_hsa046621.03366247
45Fructose and mannose metabolism_Homo sapiens_hsa000511.02485466
46Fatty acid degradation_Homo sapiens_hsa000711.01806963
47Prolactin signaling pathway_Homo sapiens_hsa049171.01150937
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00527737
49Fatty acid biosynthesis_Homo sapiens_hsa000611.00504059
50Pancreatic cancer_Homo sapiens_hsa052120.99626299
51Toxoplasmosis_Homo sapiens_hsa051450.99244354
52MicroRNAs in cancer_Homo sapiens_hsa052060.98626903
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.98252940
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97742717
55Estrogen signaling pathway_Homo sapiens_hsa049150.97595892
56Measles_Homo sapiens_hsa051620.97245774
57PPAR signaling pathway_Homo sapiens_hsa033200.96620435
58Amoebiasis_Homo sapiens_hsa051460.96467152
59TNF signaling pathway_Homo sapiens_hsa046680.95086832
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93477954
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92456308
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91112143
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89868935
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89714484
65Tuberculosis_Homo sapiens_hsa051520.89428859
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89385777
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.87245542
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86698304
69FoxO signaling pathway_Homo sapiens_hsa040680.86499866
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84166415
71Fatty acid metabolism_Homo sapiens_hsa012120.84065461
72Bile secretion_Homo sapiens_hsa049760.83710110
73ECM-receptor interaction_Homo sapiens_hsa045120.82698784
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82638627
75HTLV-I infection_Homo sapiens_hsa051660.82601885
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.82281679
77Herpes simplex infection_Homo sapiens_hsa051680.82135005
78Bladder cancer_Homo sapiens_hsa052190.81831379
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81822737
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81664832
81HIF-1 signaling pathway_Homo sapiens_hsa040660.81155135
82Osteoclast differentiation_Homo sapiens_hsa043800.80456755
83Colorectal cancer_Homo sapiens_hsa052100.79289110
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78894176
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78803542
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78025152
87Platelet activation_Homo sapiens_hsa046110.78006929
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.76636590
89Chemokine signaling pathway_Homo sapiens_hsa040620.76279896
90Biosynthesis of amino acids_Homo sapiens_hsa012300.75290647
91Galactose metabolism_Homo sapiens_hsa000520.75222072
92Long-term potentiation_Homo sapiens_hsa047200.74856877
93mRNA surveillance pathway_Homo sapiens_hsa030150.74065735
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.73869751
95Renal cell carcinoma_Homo sapiens_hsa052110.73478488
96Arginine biosynthesis_Homo sapiens_hsa002200.68900727
97Selenocompound metabolism_Homo sapiens_hsa004500.68876182
98Endocytosis_Homo sapiens_hsa041440.68749546
99Hippo signaling pathway_Homo sapiens_hsa043900.67695634
100Carbon metabolism_Homo sapiens_hsa012000.67285977
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.65136651
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64851032
103Salmonella infection_Homo sapiens_hsa051320.64634067
104Glycerolipid metabolism_Homo sapiens_hsa005610.63403993
105T cell receptor signaling pathway_Homo sapiens_hsa046600.63199518
106Malaria_Homo sapiens_hsa051440.62703780
107Shigellosis_Homo sapiens_hsa051310.62553427
108Inositol phosphate metabolism_Homo sapiens_hsa005620.62367969
109Basal cell carcinoma_Homo sapiens_hsa052170.62354191
110Staphylococcus aureus infection_Homo sapiens_hsa051500.60485746
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59438231
112Lysosome_Homo sapiens_hsa041420.59403983
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59340167
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.58951156
115Oxytocin signaling pathway_Homo sapiens_hsa049210.57996701
116ABC transporters_Homo sapiens_hsa020100.57770082
117Circadian rhythm_Homo sapiens_hsa047100.57495015
118GnRH signaling pathway_Homo sapiens_hsa049120.57100497
119Gastric acid secretion_Homo sapiens_hsa049710.55016925
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54820167
121Prostate cancer_Homo sapiens_hsa052150.54502922
122Protein digestion and absorption_Homo sapiens_hsa049740.54323478
123ErbB signaling pathway_Homo sapiens_hsa040120.53743503
124Pathways in cancer_Homo sapiens_hsa052000.53570111
125Apoptosis_Homo sapiens_hsa042100.53509175
126Thyroid cancer_Homo sapiens_hsa052160.53106257
127Choline metabolism in cancer_Homo sapiens_hsa052310.52919693
128Tight junction_Homo sapiens_hsa045300.52617608
129Epstein-Barr virus infection_Homo sapiens_hsa051690.51990787
130Viral carcinogenesis_Homo sapiens_hsa052030.51833307
131MAPK signaling pathway_Homo sapiens_hsa040100.51642676
132Hepatitis B_Homo sapiens_hsa051610.50850932
133Influenza A_Homo sapiens_hsa051640.50252327

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