USP17L9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukotriene metabolic process (GO:0006691)9.33178101
2digestion (GO:0007586)9.25450001
3intestinal absorption (GO:0050892)8.12530978
4transcytosis (GO:0045056)8.00481414
5regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)7.79210926
6icosanoid biosynthetic process (GO:0046456)7.48647690
7fatty acid derivative biosynthetic process (GO:1901570)7.48647690
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.85510239
9unsaturated fatty acid biosynthetic process (GO:0006636)6.16641312
10peptidyl-proline hydroxylation (GO:0019511)5.94872312
11cobalamin metabolic process (GO:0009235)5.73982907
12protein retention in ER lumen (GO:0006621)5.72681098
13peptide catabolic process (GO:0043171)5.36324699
14glutathione metabolic process (GO:0006749)5.22524576
15sterol catabolic process (GO:0016127)5.20345941
16cholesterol catabolic process (GO:0006707)5.20345941
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.83624703
18phosphatidylinositol acyl-chain remodeling (GO:0036149)4.68784107
19mitochondrion distribution (GO:0048311)4.59018310
20glycolipid catabolic process (GO:0019377)4.57369432
21membrane lipid catabolic process (GO:0046466)4.28737910
22regulation of phospholipase A2 activity (GO:0032429)4.28649522
23cilium or flagellum-dependent cell motility (GO:0001539)4.23139352
24protein hydroxylation (GO:0018126)4.20699834
25cysteine metabolic process (GO:0006534)4.19688650
26icosanoid metabolic process (GO:0006690)4.08071536
27fatty acid derivative metabolic process (GO:1901568)4.08071536
28detection of molecule of bacterial origin (GO:0032490)4.05786993
29regulation of G0 to G1 transition (GO:0070316)4.04947224
30digestive system process (GO:0022600)3.94103200
31ceramide catabolic process (GO:0046514)3.91580335
32phosphatidylserine acyl-chain remodeling (GO:0036150)3.86549964
33mitochondrial calcium ion transport (GO:0006851)3.86505917
34neuronal action potential (GO:0019228)3.84990312
35phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.84775216
36cholesterol transport (GO:0030301)3.65289267
37sterol transport (GO:0015918)3.65289267
38gonadal mesoderm development (GO:0007506)3.59807149
39membrane depolarization during action potential (GO:0086010)3.51965383
40regulation of RIG-I signaling pathway (GO:0039535)3.49323657
41neutrophil mediated immunity (GO:0002446)3.44576165
42protein K48-linked deubiquitination (GO:0071108)3.43919759
43unsaturated fatty acid metabolic process (GO:0033559)3.41946674
44prenylation (GO:0097354)3.27959970
45protein prenylation (GO:0018342)3.27959970
46maintenance of gastrointestinal epithelium (GO:0030277)3.24542389
47regulation of cytokine production involved in inflammatory response (GO:1900015)3.23255878
48positive regulation of endothelial cell differentiation (GO:0045603)3.15922543
49imidazole-containing compound metabolic process (GO:0052803)3.11451125
50regulation of endothelial cell differentiation (GO:0045601)3.09939841
51phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.02437416
52phospholipid catabolic process (GO:0009395)3.02194401
53regulation of hippo signaling (GO:0035330)3.01962421
54regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.01033904
55cerebellar Purkinje cell differentiation (GO:0021702)2.93082392
56arachidonic acid secretion (GO:0050482)2.91894113
57icosanoid secretion (GO:0032309)2.91894113
58negative regulation of epidermal cell differentiation (GO:0045605)2.88517561
59negative regulation of protein localization to cell surface (GO:2000009)2.87941087
60sulfation (GO:0051923)2.86234635
61fatty acid biosynthetic process (GO:0006633)2.84376299
62peristalsis (GO:0030432)2.72582186
63phosphatidylcholine acyl-chain remodeling (GO:0036151)2.71026527
64one-carbon compound transport (GO:0019755)2.69968704
65peptide metabolic process (GO:0006518)2.68161670
66myeloid leukocyte mediated immunity (GO:0002444)2.64792770
67cell communication involved in cardiac conduction (GO:0086065)2.62575552
68androgen biosynthetic process (GO:0006702)2.60905698
69phosphatidic acid metabolic process (GO:0046473)2.58719831
70phosphatidic acid biosynthetic process (GO:0006654)2.58719831
71microglial cell activation (GO:0001774)2.47081275
72glutamate metabolic process (GO:0006536)2.46620669
73establishment of skin barrier (GO:0061436)2.45692614
74negative regulation of Ras GTPase activity (GO:0034261)2.45423333
75multicellular organismal movement (GO:0050879)2.44589885
76musculoskeletal movement (GO:0050881)2.44589885
77phosphatidylserine metabolic process (GO:0006658)2.43387726
78protein K63-linked deubiquitination (GO:0070536)2.41263092
79interkinetic nuclear migration (GO:0022027)2.41220927
80motile cilium assembly (GO:0044458)2.38876187
81glycine transport (GO:0015816)2.31805431
82import into cell (GO:0098657)2.31148498
83serotonin metabolic process (GO:0042428)2.29435163
84fatty acid derivative transport (GO:1901571)2.29172276
85icosanoid transport (GO:0071715)2.29172276
86regulation of ruffle assembly (GO:1900027)2.28826229
87bone remodeling (GO:0046849)2.24804591
88phosphatidylglycerol metabolic process (GO:0046471)2.24289887
89negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.23163530
90nerve growth factor signaling pathway (GO:0038180)2.21525594
91glutathione biosynthetic process (GO:0006750)2.19413322
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.18183908
93cAMP biosynthetic process (GO:0006171)2.17201942
94epithelial structure maintenance (GO:0010669)2.16983617
95gamma-aminobutyric acid signaling pathway (GO:0007214)2.16343528
96mesenchymal cell differentiation involved in kidney development (GO:0072161)2.16211607
97mesenchymal cell differentiation involved in renal system development (GO:2001012)2.16211607
98cellular modified amino acid catabolic process (GO:0042219)2.15703798
99intestinal cholesterol absorption (GO:0030299)18.3880028
100leukotriene biosynthetic process (GO:0019370)13.5273695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.73623270
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76587085
3GBX2_23144817_ChIP-Seq_PC3_Human3.33772522
4EZH2_22144423_ChIP-Seq_EOC_Human3.19390073
5VDR_22108803_ChIP-Seq_LS180_Human2.96596464
6DROSHA_22980978_ChIP-Seq_HELA_Human2.73164108
7TAF15_26573619_Chip-Seq_HEK293_Human2.53363273
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18633152
9GATA1_22025678_ChIP-Seq_K562_Human2.02209088
10AR_21572438_ChIP-Seq_LNCaP_Human1.86757811
11SMAD_19615063_ChIP-ChIP_OVARY_Human1.80005140
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77436497
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71952892
14TP53_16413492_ChIP-PET_HCT116_Human1.69576213
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67258949
16SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67112279
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64618524
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61693070
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52442507
20ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50269680
21SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49673880
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47684852
23STAT3_23295773_ChIP-Seq_U87_Human1.47377454
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.46358182
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45756006
26SMAD4_21741376_ChIP-Seq_EPCs_Human1.44756409
27P300_19829295_ChIP-Seq_ESCs_Human1.43346978
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41442051
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41134231
30SMAD4_21799915_ChIP-Seq_A2780_Human1.39249503
31GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36617168
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.36511304
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34865640
34BCAT_22108803_ChIP-Seq_LS180_Human1.32967722
35NFYA_21822215_ChIP-Seq_K562_Human1.32495141
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30487718
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.30448943
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.29542113
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29086839
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28665214
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27566217
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26155278
43OCT1_27270436_Chip-Seq_PROSTATE_Human1.23880393
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23865988
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23842123
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22259965
47TCF4_23295773_ChIP-Seq_U87_Human1.20282624
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.18437418
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18183557
50CBP_20019798_ChIP-Seq_JUKART_Human1.18183557
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17805213
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16835543
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14066528
54TBL1_22424771_ChIP-Seq_293T_Human1.13095628
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.12791375
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10480893
57CDX2_22108803_ChIP-Seq_LS180_Human1.10469952
58CJUN_26792858_Chip-Seq_BT549_Human1.10117389
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09928446
60RUNX2_22187159_ChIP-Seq_PCA_Human1.09832297
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09810567
62ER_23166858_ChIP-Seq_MCF-7_Human1.09305690
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.08927320
64NFYB_21822215_ChIP-Seq_K562_Human1.07784908
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07517784
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05996787
67REST_21632747_ChIP-Seq_MESCs_Mouse1.04660013
68SMAD3_21741376_ChIP-Seq_ESCs_Human1.02457672
69RXR_22108803_ChIP-Seq_LS180_Human1.02132849
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.01894267
71CBP_21632823_ChIP-Seq_H3396_Human1.01608975
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00396312
73POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98609853
74JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98339740
75AHR_22903824_ChIP-Seq_MCF-7_Human0.96421143
76KLF5_25053715_ChIP-Seq_YYC3_Human0.96144342
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95918866
78SOX2_21211035_ChIP-Seq_LN229_Gbm0.95805937
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95793813
80PHF8_20622853_ChIP-Seq_HELA_Human0.95639415
81FLI1_27457419_Chip-Seq_LIVER_Mouse0.95067859
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94692149
83TCF4_22108803_ChIP-Seq_LS180_Human0.94614919
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94334877
85HNFA_21074721_ChIP-Seq_CACO-2_Human0.94029293
86IRF1_19129219_ChIP-ChIP_H3396_Human0.92748374
87OCT4_20526341_ChIP-Seq_ESCs_Human0.91979657
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91899815
89AR_19668381_ChIP-Seq_PC3_Human0.91758854
90LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91711327
91KDM2B_26808549_Chip-Seq_REH_Human0.91604084
92ETV1_20927104_ChIP-Seq_GIST48_Human0.91216574
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91168292
94MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90997325
95AR_25329375_ChIP-Seq_VCAP_Human0.90650555
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90168744
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.89274199
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88878181
99TP53_18474530_ChIP-ChIP_U2OS_Human0.88443203
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.87808363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption8.49932468
2MP0003868_abnormal_feces_composition5.80954873
3MP0003183_abnormal_peptide_metabolism5.35455877
4MP0003959_abnormal_lean_body4.34012502
5MP0005365_abnormal_bile_salt3.91016795
6MP0000569_abnormal_digit_pigmentation3.76101272
7MP0005220_abnormal_exocrine_pancreas3.39584729
8MP0002736_abnormal_nociception_after3.28158795
9MP0003878_abnormal_ear_physiology2.80693094
10MP0005377_hearing/vestibular/ear_phenot2.80693094
11MP0002822_catalepsy2.75729929
12MP0000465_gastrointestinal_hemorrhage2.67638604
13MP0003300_gastrointestinal_ulcer2.55148370
14MP0000613_abnormal_salivary_gland2.36269927
15MP0001968_abnormal_touch/_nociception2.33232224
16MP0003195_calcinosis2.27314368
17MP0002163_abnormal_gland_morphology2.26005709
18MP0002138_abnormal_hepatobiliary_system2.24573568
19MP0003879_abnormal_hair_cell2.08245815
20MP0002089_abnormal_postnatal_growth/wei2.07231070
21MP0003045_fibrosis2.01102669
22MP0005448_abnormal_energy_balance1.80160208
23MP0005083_abnormal_biliary_tract1.78442942
24MP0001485_abnormal_pinna_reflex1.70339952
25MP0003950_abnormal_plasma_membrane1.44823178
26MP0001501_abnormal_sleep_pattern1.42994697
27MP0005379_endocrine/exocrine_gland_phen1.30594640
28MP0002733_abnormal_thermal_nociception1.28776817
29MP0002332_abnormal_exercise_endurance1.28618750
30MP0003136_yellow_coat_color1.26255370
31MP0000371_diluted_coat_color1.19524068
32MP0004043_abnormal_pH_regulation1.17114266
33MP0008995_early_reproductive_senescence1.15911333
34MP0001879_abnormal_lymphatic_vessel1.15741724
35MP0002735_abnormal_chemical_nociception1.15032895
36MP0005551_abnormal_eye_electrophysiolog1.14447992
37MP0004264_abnormal_extraembryonic_tissu1.11803032
38MP0003866_abnormal_defecation1.10608425
39MP0010678_abnormal_skin_adnexa1.10602105
40MP0006276_abnormal_autonomic_nervous1.09316328
41MP0000383_abnormal_hair_follicle1.08609608
42MP0001664_abnormal_digestion1.04431414
43MP0005171_absent_coat_pigmentation1.02468541
44MP0005645_abnormal_hypothalamus_physiol0.99731334
45MP0008872_abnormal_physiological_respon0.98415777
46MP0000579_abnormal_nail_morphology0.98308400
47MP0010368_abnormal_lymphatic_system0.97040097
48MP0004742_abnormal_vestibular_system0.96434225
49MP0005409_darkened_coat_color0.95747366
50MP0002272_abnormal_nervous_system0.94441727
51MP0003252_abnormal_bile_duct0.88177955
52MP0005174_abnormal_tail_pigmentation0.87552826
53MP0005167_abnormal_blood-brain_barrier0.84949854
54MP0001765_abnormal_ion_homeostasis0.84863224
55MP0005275_abnormal_skin_tensile0.82200593
56MP0010386_abnormal_urinary_bladder0.81118126
57MP0001970_abnormal_pain_threshold0.79701741
58MP0003828_pulmonary_edema0.78841143
59MP0003091_abnormal_cell_migration0.77523217
60MP0005670_abnormal_white_adipose0.76844805
61MP0002118_abnormal_lipid_homeostasis0.76175137
62MP0010234_abnormal_vibrissa_follicle0.75738380
63MP0004019_abnormal_vitamin_homeostasis0.75512243
64MP0001756_abnormal_urination0.75243892
65MP0002928_abnormal_bile_duct0.74373435
66MP0003953_abnormal_hormone_level0.73736100
67MP0002067_abnormal_sensory_capabilities0.73038890
68MP0002693_abnormal_pancreas_physiology0.71870040
69MP0002168_other_aberrant_phenotype0.71834675
70MP0004215_abnormal_myocardial_fiber0.71242994
71MP0009046_muscle_twitch0.68945871
72MP0008004_abnormal_stomach_pH0.68097203
73MP0003632_abnormal_nervous_system0.65644636
74MP0002796_impaired_skin_barrier0.64778166
75MP0000470_abnormal_stomach_morphology0.64223800
76MP0002229_neurodegeneration0.63336373
77MP0000015_abnormal_ear_pigmentation0.63084963
78MP0002877_abnormal_melanocyte_morpholog0.62859981
79MP0002078_abnormal_glucose_homeostasis0.62709413
80MP0005464_abnormal_platelet_physiology0.58667380
81MP0000230_abnormal_systemic_arterial0.56500300
82MP0001663_abnormal_digestive_system0.56033803
83MP0001502_abnormal_circadian_rhythm0.54507643
84MP0006138_congestive_heart_failure0.54229589
85MP0005452_abnormal_adipose_tissue0.53914208
86MP0003690_abnormal_glial_cell0.53609644
87MP0001486_abnormal_startle_reflex0.51890552
88MP0005266_abnormal_metabolism0.51156228
89MP0005410_abnormal_fertilization0.51020769
90MP0002075_abnormal_coat/hair_pigmentati0.50166967
91MP0000427_abnormal_hair_cycle0.48667305
92MP0010771_integument_phenotype0.48218065
93MP0003635_abnormal_synaptic_transmissio0.47864112
94MP0005085_abnormal_gallbladder_physiolo0.47500180
95MP0003633_abnormal_nervous_system0.46672891
96MP0002638_abnormal_pupillary_reflex0.46329940
97MP0003631_nervous_system_phenotype0.46117385
98MP0003941_abnormal_skin_development0.46016330
99MP0005248_abnormal_Harderian_gland0.44892029
100MP0001963_abnormal_hearing_physiology0.44473461

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)8.50168262
2Fat malabsorption (HP:0002630)6.37896708
3Thoracolumbar scoliosis (HP:0002944)5.30833201
4Abnormality of the lumbar spine (HP:0100712)5.23116868
5Thoracic kyphosis (HP:0002942)5.18576207
6Deformed sella turcica (HP:0002681)4.28096392
7Congenital sensorineural hearing impairment (HP:0008527)4.11998955
8Hypoproteinemia (HP:0003075)3.98301941
9Palpebral edema (HP:0100540)3.98258411
10Broad ribs (HP:0000885)3.72158975
11Abnormality of the sella turcica (HP:0002679)3.66155596
12Clumsiness (HP:0002312)3.61853024
13Flat acetabular roof (HP:0003180)3.47257170
14Abnormality of the thoracic spine (HP:0100711)3.41567679
15J-shaped sella turcica (HP:0002680)3.40901155
16Carpal bone hypoplasia (HP:0001498)3.38990020
17Aortic regurgitation (HP:0001659)3.16643703
18Spontaneous hematomas (HP:0007420)3.13688508
19Vertebral arch anomaly (HP:0008438)3.12741403
20Genetic anticipation (HP:0003743)3.01964402
21Dynein arm defect of respiratory motile cilia (HP:0012255)2.93423765
22Absent/shortened dynein arms (HP:0200106)2.93423765
23Exocrine pancreatic insufficiency (HP:0001738)2.92282740
24Decreased circulating renin level (HP:0003351)2.85561975
25Short 4th metacarpal (HP:0010044)2.85288173
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.85288173
27Neoplasm of the heart (HP:0100544)2.83813955
28Abnormality of chloride homeostasis (HP:0011422)2.81537410
29Protruding tongue (HP:0010808)2.79259830
30Bilateral sensorineural hearing impairment (HP:0008619)2.78990247
31Hyperkalemia (HP:0002153)2.73421847
32Thickened calvaria (HP:0002684)2.63077592
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.63017425
34Urethral obstruction (HP:0000796)2.57196793
35Abnormal pancreas size (HP:0012094)2.56832318
36Ileus (HP:0002595)2.56624026
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.53574693
38Esophageal varix (HP:0002040)2.52119859
39Diastasis recti (HP:0001540)2.50209697
40Abnormal ciliary motility (HP:0012262)2.45723307
41Abnormality of the right ventricle (HP:0001707)2.42900951
42Broad alveolar ridges (HP:0000187)2.42810323
43Portal hypertension (HP:0001409)2.41456457
44Short phalanx of the thumb (HP:0009660)2.39051800
45Fibular aplasia (HP:0002990)2.34577377
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.31433215
47Facial shape deformation (HP:0011334)2.24440579
48Potter facies (HP:0002009)2.24440579
49Corneal erosion (HP:0200020)2.21103953
50Abnormality of the hepatic vasculature (HP:0006707)2.17611572
51Onion bulb formation (HP:0003383)2.14820995
52Milia (HP:0001056)2.12142858
53Fair hair (HP:0002286)2.10832264
54Abnormality of the columella (HP:0009929)2.09035560
55Conjunctival telangiectasia (HP:0000524)2.09022513
56Progressive cerebellar ataxia (HP:0002073)2.08020838
57Craniofacial hyperostosis (HP:0004493)2.06913555
58Visual hallucinations (HP:0002367)2.04318921
59Abnormal hair laboratory examination (HP:0003328)2.02980640
60Central scotoma (HP:0000603)2.02094417
61Choroideremia (HP:0001139)2.01751010
62Abnormality of the odontoid process (HP:0003310)2.01493962
63Gaze-evoked nystagmus (HP:0000640)2.00053453
64Menorrhagia (HP:0000132)1.99872025
65Abnormality of the distal phalanx of the thumb (HP:0009617)1.93264614
66Attenuation of retinal blood vessels (HP:0007843)1.90291327
67Periorbital edema (HP:0100539)1.89941287
68Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.89187020
69Asymmetry of the thorax (HP:0001555)1.88628802
70Increased mean platelet volume (HP:0011877)1.88571964
71Abnormality of the renal cortex (HP:0011035)1.87359630
72Mask-like facies (HP:0000298)1.86706982
73Facial diplegia (HP:0001349)1.85706513
74Abnormality of the 4th metacarpal (HP:0010012)1.85062009
75Prolonged bleeding time (HP:0003010)1.84456385
76Stereotypic behavior (HP:0000733)1.84121961
77Facial edema (HP:0000282)1.83451417
78Hyperventilation (HP:0002883)1.82072870
79Down-sloping shoulders (HP:0200021)1.81659931
80Hyperaldosteronism (HP:0000859)1.81451015
81Abnormality of renin-angiotensin system (HP:0000847)1.79751836
82Tracheomalacia (HP:0002779)1.78720641
83Bony spicule pigmentary retinopathy (HP:0007737)1.78585931
84Generalized hypopigmentation of hair (HP:0011358)1.77969584
85Oral leukoplakia (HP:0002745)1.76860127
86Cranial hyperostosis (HP:0004437)1.76786611
87Cystic liver disease (HP:0006706)1.76680667
88Dysmetric saccades (HP:0000641)1.76614291
89Increased cerebral lipofuscin (HP:0011813)1.76483542
90Hypophosphatemic rickets (HP:0004912)1.74276560
91Abnormality of potassium homeostasis (HP:0011042)1.72214510
92Flared iliac wings (HP:0002869)1.72205427
93Abolished electroretinogram (ERG) (HP:0000550)1.71318812
94Abnormality of the pons (HP:0007361)1.69709833
95Pili torti (HP:0003777)1.69253394
96Recurrent bronchitis (HP:0002837)1.69194519
97Abnormality of the vasculature of the conjunctiva (HP:0008054)1.68678150
98Nonprogressive disorder (HP:0003680)1.67849289
99Urinary glycosaminoglycan excretion (HP:0003541)1.67710495
100Mucopolysacchariduria (HP:0008155)1.67710495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.70598680
2LATS15.12485293
3BLK3.90676419
4LMTK23.81295749
5FRK3.64824795
6NME12.78105641
7MST1R2.71026195
8TIE12.59074509
9NTRK32.30877382
10NUAK11.96208943
11MAP3K21.83298878
12BMPR1B1.80250871
13ACVR1B1.77215900
14PIK3CG1.75807931
15MAP3K31.70211009
16WNK41.66621079
17EPHA31.62258015
18EIF2AK31.62256729
19MET1.55852446
20SGK21.51519621
21MAP2K31.35441414
22WNK11.32945296
23PTK2B1.30575461
24IRAK11.29086837
25EPHA21.26509080
26SGK4941.14393364
27SGK2231.14393364
28GRK51.11893061
29RET1.01591002
30TEC1.00872632
31TAOK31.00818712
32FER1.00605264
33NLK0.92004190
34SGK30.89689663
35MAP2K10.89600281
36MAP3K70.89062431
37GRK10.87916578
38MAP2K20.82511904
39DAPK20.81397035
40MELK0.80979223
41CAMK40.80870140
42STK30.80674871
43DDR20.76517415
44ADRBK10.75273464
45FES0.74714880
46FGR0.70828207
47STK38L0.69117132
48GRK70.64966243
49KDR0.63846109
50MAP3K10.63706800
51MAP3K50.62884268
52SGK10.61945172
53ERBB20.61905233
54ADRBK20.58226581
55ITK0.56643946
56TGFBR10.56492599
57TNIK0.54239334
58SYK0.54178305
59BTK0.53767144
60MAP3K90.53331365
61FGFR30.52580850
62PDK10.49365556
63TRIB30.49092788
64STK240.49010112
65HCK0.47728299
66EPHB10.47227183
67JAK10.45839815
68MAP2K60.45723846
69MATK0.45594293
70MUSK0.44511020
71DYRK1A0.43133968
72IKBKE0.42566450
73CDK120.41576561
74TNK20.40237084
75JAK20.39136723
76PDGFRB0.38664579
77PKN20.38036681
78BMX0.37837641
79MAP3K40.37059566
80TGFBR20.36923830
81MAP3K60.36163093
82LYN0.34334903
83PIM10.33688672
84IRAK40.32765611
85RPS6KB20.32452301
86MST40.31220897
87PRKCE0.28938818
88PDPK10.27555373
89MARK20.25867271
90HIPK20.24755952
91FGFR40.24445398
92ZAP700.24002934
93IGF1R0.22736406
94FYN0.22461268
95CSNK1A10.22186409
96PRKAA20.22061368
97IRAK20.21854333
98INSR0.21689496
99CAMK2B0.21422825
100MAP2K40.20932474

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.54573620
2Fat digestion and absorption_Homo sapiens_hsa049756.06339011
3Protein digestion and absorption_Homo sapiens_hsa049744.97146750
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.75244548
5Glycerolipid metabolism_Homo sapiens_hsa005613.69943862
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.73600389
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30288487
8Vitamin digestion and absorption_Homo sapiens_hsa049772.13229629
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83403646
10Steroid biosynthesis_Homo sapiens_hsa001001.73964654
11Linoleic acid metabolism_Homo sapiens_hsa005911.69251921
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.57596829
13Histidine metabolism_Homo sapiens_hsa003401.49266865
14Starch and sucrose metabolism_Homo sapiens_hsa005001.45722667
15Arachidonic acid metabolism_Homo sapiens_hsa005901.39849130
16Taste transduction_Homo sapiens_hsa047421.26653487
17Ether lipid metabolism_Homo sapiens_hsa005651.24123190
18Renin-angiotensin system_Homo sapiens_hsa046141.22242703
19Nicotine addiction_Homo sapiens_hsa050331.15547182
20Ovarian steroidogenesis_Homo sapiens_hsa049131.14682160
21ABC transporters_Homo sapiens_hsa020101.11981374
22Vascular smooth muscle contraction_Homo sapiens_hsa042700.98662339
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98269261
24Salivary secretion_Homo sapiens_hsa049700.95720941
25Morphine addiction_Homo sapiens_hsa050320.86416597
26Selenocompound metabolism_Homo sapiens_hsa004500.82904440
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82348596
28Serotonergic synapse_Homo sapiens_hsa047260.81380691
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75736352
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73250009
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67608378
32Glutamatergic synapse_Homo sapiens_hsa047240.66558929
33Circadian entrainment_Homo sapiens_hsa047130.65730656
34GABAergic synapse_Homo sapiens_hsa047270.65591767
35Tryptophan metabolism_Homo sapiens_hsa003800.64825799
36Bile secretion_Homo sapiens_hsa049760.64145246
37Platelet activation_Homo sapiens_hsa046110.63738978
38Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60077459
39Calcium signaling pathway_Homo sapiens_hsa040200.57162580
40Gastric acid secretion_Homo sapiens_hsa049710.56950422
41Olfactory transduction_Homo sapiens_hsa047400.55783201
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53243075
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52938004
44Insulin secretion_Homo sapiens_hsa049110.52335184
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.51896731
46GnRH signaling pathway_Homo sapiens_hsa049120.51800574
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.50493432
48cAMP signaling pathway_Homo sapiens_hsa040240.49669737
49Cocaine addiction_Homo sapiens_hsa050300.47593739
50Renin secretion_Homo sapiens_hsa049240.47029960
51Gap junction_Homo sapiens_hsa045400.46628768
52Cholinergic synapse_Homo sapiens_hsa047250.45605561
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42390871
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40801428
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.40753615
56Dorso-ventral axis formation_Homo sapiens_hsa043200.39792564
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37062504
58Influenza A_Homo sapiens_hsa051640.36793346
59Amphetamine addiction_Homo sapiens_hsa050310.35672232
60ECM-receptor interaction_Homo sapiens_hsa045120.33187187
61Non-small cell lung cancer_Homo sapiens_hsa052230.31426715
62Long-term depression_Homo sapiens_hsa047300.30145424
63beta-Alanine metabolism_Homo sapiens_hsa004100.29611970
64Ras signaling pathway_Homo sapiens_hsa040140.29481642
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28978867
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28804185
67Phototransduction_Homo sapiens_hsa047440.28650703
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28544772
69Long-term potentiation_Homo sapiens_hsa047200.26384447
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24757613
71Fatty acid biosynthesis_Homo sapiens_hsa000610.23983455
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23938490
73Rap1 signaling pathway_Homo sapiens_hsa040150.22739016
74Thyroid hormone synthesis_Homo sapiens_hsa049180.22465622
75Vibrio cholerae infection_Homo sapiens_hsa051100.21904535
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21561665
77Retinol metabolism_Homo sapiens_hsa008300.21425018
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21046892
79Dilated cardiomyopathy_Homo sapiens_hsa054140.20027333
80Estrogen signaling pathway_Homo sapiens_hsa049150.19727226
81Melanoma_Homo sapiens_hsa052180.18701381
82Type II diabetes mellitus_Homo sapiens_hsa049300.17323933
83Glutathione metabolism_Homo sapiens_hsa004800.16641830
84Oxytocin signaling pathway_Homo sapiens_hsa049210.16248537
85Tight junction_Homo sapiens_hsa045300.16042150
86MAPK signaling pathway_Homo sapiens_hsa040100.15408794
87Hedgehog signaling pathway_Homo sapiens_hsa043400.15118774
88Glioma_Homo sapiens_hsa052140.15109364
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13006246
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12976279
91Systemic lupus erythematosus_Homo sapiens_hsa053220.10948232
92Inositol phosphate metabolism_Homo sapiens_hsa005620.10918334
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10636540
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10599771
95Alcoholism_Homo sapiens_hsa050340.10348543
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09280112
97Prostate cancer_Homo sapiens_hsa052150.08544285
98PPAR signaling pathway_Homo sapiens_hsa033200.08131724
99Bladder cancer_Homo sapiens_hsa052190.07954084
100Lysine degradation_Homo sapiens_hsa003100.07179946

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