USP17L22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial structure maintenance (GO:0010669)8.40297212
2response to vitamin A (GO:0033189)7.80551172
3mesenchymal cell differentiation involved in renal system development (GO:2001012)7.56479517
4mesenchymal cell differentiation involved in kidney development (GO:0072161)7.56479517
5sperm capacitation (GO:0048240)6.78228958
6cellular response to epidermal growth factor stimulus (GO:0071364)6.33114291
7O-glycan processing (GO:0016266)6.19969137
8protein-chromophore linkage (GO:0018298)6.05041336
9histone H3-K36 demethylation (GO:0070544)5.77584984
10membrane depolarization during action potential (GO:0086010)5.72718136
11multicellular organism reproduction (GO:0032504)5.63590103
12rRNA catabolic process (GO:0016075)5.58601078
13calcium ion import (GO:0070509)5.47418977
14positive regulation of sodium ion transmembrane transporter activity (GO:2000651)5.25980723
15cGMP-mediated signaling (GO:0019934)5.02661614
16nephron tubule morphogenesis (GO:0072078)4.90948964
17nephron epithelium morphogenesis (GO:0072088)4.90948964
18regulation of platelet aggregation (GO:0090330)4.79393133
19response to epidermal growth factor (GO:0070849)4.73252289
20cellular response to glucocorticoid stimulus (GO:0071385)4.72806297
21negative regulation of homotypic cell-cell adhesion (GO:0034111)4.69187520
22relaxation of smooth muscle (GO:0044557)4.67790364
23regulation of ARF GTPase activity (GO:0032312)4.64254793
24sphingosine metabolic process (GO:0006670)4.52145090
25C21-steroid hormone biosynthetic process (GO:0006700)4.49328663
26DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.47469646
27cellular response to corticosteroid stimulus (GO:0071384)4.34661060
28phosphate ion homeostasis (GO:0055062)4.25459949
29trivalent inorganic anion homeostasis (GO:0072506)4.25459949
30protein O-linked glycosylation (GO:0006493)4.22359645
31behavioral response to nicotine (GO:0035095)4.20380498
32negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.15993391
33membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.14657393
34diol metabolic process (GO:0034311)4.04231813
35L-fucose catabolic process (GO:0042355)4.03505865
36fucose catabolic process (GO:0019317)4.03505865
37L-fucose metabolic process (GO:0042354)4.03505865
38tachykinin receptor signaling pathway (GO:0007217)4.02147901
39positive regulation of histone deacetylation (GO:0031065)4.01833009
40negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.97719458
41cellular anion homeostasis (GO:0030002)3.97494787
42negative regulation of digestive system process (GO:0060457)3.97044122
43regulation of RIG-I signaling pathway (GO:0039535)3.96419347
44DNA damage response, signal transduction resulting in transcription (GO:0042772)3.93917627
45regulation of acrosome reaction (GO:0060046)3.89211380
46glucocorticoid biosynthetic process (GO:0006704)3.76390755
47striated muscle atrophy (GO:0014891)3.75476595
48regulation of histone deacetylation (GO:0031063)3.74654085
49establishment of protein localization to Golgi (GO:0072600)3.74632338
50phosphatidylglycerol biosynthetic process (GO:0006655)3.72005821
51renal tubule morphogenesis (GO:0061333)3.67761544
52phosphate ion transmembrane transport (GO:0035435)3.66500776
53positive regulation of sodium ion transmembrane transport (GO:1902307)3.66033157
54membrane repolarization during action potential (GO:0086011)3.65937317
55rhodopsin mediated signaling pathway (GO:0016056)3.59772136
56protein targeting to Golgi (GO:0000042)3.56763462
57actin filament capping (GO:0051693)3.52105534
58reproduction (GO:0000003)3.51775473
59regulation of mitochondrial translation (GO:0070129)3.50166048
60skeletal muscle adaptation (GO:0043501)3.41865217
61retrograde transport, vesicle recycling within Golgi (GO:0000301)3.39478444
62ceramide catabolic process (GO:0046514)3.39379980
63digestive system process (GO:0022600)3.39135913
64motile cilium assembly (GO:0044458)3.36158589
65regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.33045038
66sphingoid metabolic process (GO:0046519)3.29181789
67auditory receptor cell stereocilium organization (GO:0060088)3.27866546
68phosphate ion transport (GO:0006817)3.25914958
69positive regulation by host of viral transcription (GO:0043923)3.23864924
70muscle atrophy (GO:0014889)3.13899501
71Arp2/3 complex-mediated actin nucleation (GO:0034314)3.13141759
72fucosylation (GO:0036065)3.12822424
73response to pheromone (GO:0019236)3.10230990
74positive regulation of interleukin-17 production (GO:0032740)3.05166588
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00098726
76mesenchymal cell differentiation (GO:0048762)2.94714018
77cardiolipin metabolic process (GO:0032048)2.93986086
78actin nucleation (GO:0045010)2.92975546
79bone trabecula formation (GO:0060346)2.90804047
80negative regulation of actin filament depolymerization (GO:0030835)2.88718151
81negative regulation of leukocyte chemotaxis (GO:0002689)2.87292454
82negative regulation of platelet activation (GO:0010544)2.85800977
83regulation of homotypic cell-cell adhesion (GO:0034110)2.84252040
84myoblast fusion (GO:0007520)2.80423366
85striated muscle adaptation (GO:0014888)2.76184817
86epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.76056939
87protein localization to Golgi apparatus (GO:0034067)2.75501753
88single fertilization (GO:0007338)2.74987564
89cardiac conduction (GO:0061337)2.72746607
90positive regulation of protein deacetylation (GO:0090312)2.68231665
91vocalization behavior (GO:0071625)2.68116769
92positive regulation of uterine smooth muscle contraction (GO:0070474)2.68115069
93renal absorption (GO:0070293)2.66634659
94cilium or flagellum-dependent cell motility (GO:0001539)2.66474699
95calcium ion transmembrane transport (GO:0070588)2.65989653
96negative regulation by host of viral transcription (GO:0043922)2.65258060
97regulation of ruffle assembly (GO:1900027)2.65013017
98regulation of gonadotropin secretion (GO:0032276)2.62942457
99regulation of G0 to G1 transition (GO:0070316)12.7330986
100maintenance of gastrointestinal epithelium (GO:0030277)11.5448607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human5.04663397
2DROSHA_22980978_ChIP-Seq_HELA_Human4.31333796
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.03958007
4EZH2_22144423_ChIP-Seq_EOC_Human3.46439007
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13383546
6GBX2_23144817_ChIP-Seq_PC3_Human2.92139409
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.19440102
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19329900
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.08893761
10CDX2_20551321_ChIP-Seq_CACO-2_Human1.84428362
11CTCF_27219007_Chip-Seq_Bcells_Human1.78882116
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77776672
13WDR5_24793694_ChIP-Seq_LNCAP_Human1.77242626
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73052579
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68843256
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65162076
17SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64851746
18SMC4_20622854_ChIP-Seq_HELA_Human1.61652253
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.57819461
20BCAT_22108803_ChIP-Seq_LS180_Human1.55678268
21VDR_22108803_ChIP-Seq_LS180_Human1.51681074
22AR_21572438_ChIP-Seq_LNCaP_Human1.49120226
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47810392
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46946062
25ER_23166858_ChIP-Seq_MCF-7_Human1.45129947
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43465412
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42307715
28AHR_22903824_ChIP-Seq_MCF-7_Human1.41817906
29BCL6_27268052_Chip-Seq_Bcells_Human1.41532307
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37502223
31E2F1_20622854_ChIP-Seq_HELA_Human1.36979288
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35657592
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.35579345
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34431640
35NFYA_21822215_ChIP-Seq_K562_Human1.34089877
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33265829
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33265829
38EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31664326
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31219574
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30951110
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30821790
42OCT4_20526341_ChIP-Seq_ESCs_Human1.29135192
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26410563
44ZNF274_21170338_ChIP-Seq_K562_Hela1.26086518
45P68_20966046_ChIP-Seq_HELA_Human1.25339382
46SA1_27219007_Chip-Seq_Bcells_Human1.25181978
47EGR1_19032775_ChIP-ChIP_M12_Human1.24891490
48CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.23563316
49BCOR_27268052_Chip-Seq_Bcells_Human1.21906764
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21381324
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.20134001
52CTCF_20526341_ChIP-Seq_ESCs_Human1.19476010
53AR_25329375_ChIP-Seq_VCAP_Human1.18739568
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18632043
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.18011811
56NFYB_21822215_ChIP-Seq_K562_Human1.17551546
57TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16817140
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.16607139
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16462357
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15046513
61TAF15_26573619_Chip-Seq_HEK293_Human1.14498377
62TCF4_23295773_ChIP-Seq_U87_Human1.14480591
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14456391
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13923730
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13427884
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13080504
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12751508
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.12335022
69AR_20517297_ChIP-Seq_VCAP_Human1.11610880
70TBL1_22424771_ChIP-Seq_293T_Human1.10777865
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08566883
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07198828
73CDX2_22108803_ChIP-Seq_LS180_Human1.06774987
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.05663437
75STAT3_23295773_ChIP-Seq_U87_Human1.03129280
76SMAD4_21799915_ChIP-Seq_A2780_Human1.02467446
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00808573
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.00647360
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99504426
80CBP_20019798_ChIP-Seq_JUKART_Human0.99504426
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99235234
82AR_19668381_ChIP-Seq_PC3_Human0.99225584
83TCF4_18268006_ChIP-ChIP_LS174T_Human0.98677964
84NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97923563
85SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97774790
86KLF5_25053715_ChIP-Seq_YYC3_Human0.97680548
87RUNX2_22187159_ChIP-Seq_PCA_Human0.97611558
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96748685
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95957997
90RAC3_21632823_ChIP-Seq_H3396_Human0.95954151
91RUNX1_27514584_Chip-Seq_MCF-7_Human0.95580389
92IGF1R_20145208_ChIP-Seq_DFB_Human0.95232026
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95027494
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94984381
95ERA_21632823_ChIP-Seq_H3396_Human0.94760984
96TP63_22573176_ChIP-Seq_HFKS_Human0.94016019
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.93511969
98REST_21632747_ChIP-Seq_MESCs_Mouse0.93136250
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.92643933
100TAF2_19829295_ChIP-Seq_ESCs_Human0.92382978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.95120293
2MP0004043_abnormal_pH_regulation5.30963362
3MP0000465_gastrointestinal_hemorrhage4.43371378
4MP0003879_abnormal_hair_cell4.22137024
5MP0000579_abnormal_nail_morphology3.96872189
6MP0002822_catalepsy3.60295259
7MP0001661_extended_life_span3.46655416
8MP0003950_abnormal_plasma_membrane3.37358114
9MP0003705_abnormal_hypodermis_morpholog2.68146925
10MP0001485_abnormal_pinna_reflex2.61526216
11MP0001664_abnormal_digestion2.54357574
12MP0009697_abnormal_copulation2.45668335
13MP0010386_abnormal_urinary_bladder2.43502090
14MP0005377_hearing/vestibular/ear_phenot2.39137058
15MP0003878_abnormal_ear_physiology2.39137058
16MP0000566_synostosis2.25858182
17MP0003866_abnormal_defecation2.20898825
18MP0005275_abnormal_skin_tensile2.03995522
19MP0001765_abnormal_ion_homeostasis1.88431944
20MP0001502_abnormal_circadian_rhythm1.86421571
21MP0004742_abnormal_vestibular_system1.85160921
22MP0001666_abnormal_nutrient_absorption1.79380971
23MP0001663_abnormal_digestive_system1.77693101
24MP0003183_abnormal_peptide_metabolism1.75970967
25MP0003195_calcinosis1.74018261
26MP0003045_fibrosis1.72390097
27MP0004145_abnormal_muscle_electrophysio1.71219179
28MP0004019_abnormal_vitamin_homeostasis1.66315833
29MP0000749_muscle_degeneration1.64866676
30MP0003646_muscle_fatigue1.62778187
31MP0005551_abnormal_eye_electrophysiolog1.61954731
32MP0004084_abnormal_cardiac_muscle1.60272155
33MP0000383_abnormal_hair_follicle1.59846642
34MP0000751_myopathy1.59393074
35MP0004036_abnormal_muscle_relaxation1.57800301
36MP0000538_abnormal_urinary_bladder1.57680010
37MP0008004_abnormal_stomach_pH1.57200593
38MP0001764_abnormal_homeostasis1.56257810
39MP0005381_digestive/alimentary_phenotyp1.55888574
40MP0001963_abnormal_hearing_physiology1.51456631
41MP0002735_abnormal_chemical_nociception1.48333838
42MP0008438_abnormal_cutaneous_collagen1.47040156
43MP0000427_abnormal_hair_cycle1.44726956
44MP0008057_abnormal_DNA_replication1.39504315
45MP0003191_abnormal_cellular_cholesterol1.28675288
46MP0005253_abnormal_eye_physiology1.24906980
47MP0001873_stomach_inflammation1.24657437
48MP0000372_irregular_coat_pigmentation1.18365533
49MP0002102_abnormal_ear_morphology1.15549533
50MP0002138_abnormal_hepatobiliary_system1.10566234
51MP0010678_abnormal_skin_adnexa1.09271918
52MP0003252_abnormal_bile_duct1.05885582
53MP0000026_abnormal_inner_ear1.03448983
54MP0004142_abnormal_muscle_tone1.02320071
55MP0000230_abnormal_systemic_arterial1.00887651
56MP0002269_muscular_atrophy1.00809664
57MP0008995_early_reproductive_senescence0.97356480
58MP0002733_abnormal_thermal_nociception0.95302436
59MP0002098_abnormal_vibrissa_morphology0.92208786
60MP0005360_urolithiasis0.91509318
61MP0009384_cardiac_valve_regurgitation0.85500496
62MP0010155_abnormal_intestine_physiology0.84743856
63MP0003091_abnormal_cell_migration0.84532686
64MP0002229_neurodegeneration0.84393237
65MP0000470_abnormal_stomach_morphology0.82607726
66MP0008872_abnormal_physiological_respon0.82383280
67MP0001243_abnormal_dermal_layer0.81254485
68MP0003172_abnormal_lysosome_physiology0.78583485
69MP0000049_abnormal_middle_ear0.76854922
70MP0005083_abnormal_biliary_tract0.76419087
71MP0002060_abnormal_skin_morphology0.73355173
72MP0000747_muscle_weakness0.73144908
73MP0003786_premature_aging0.71543177
74MP0003137_abnormal_impulse_conducting0.71059740
75MP0000647_abnormal_sebaceous_gland0.69229097
76MP0001968_abnormal_touch/_nociception0.68048388
77MP0002896_abnormal_bone_mineralization0.67522012
78MP0000371_diluted_coat_color0.67467117
79MP0009046_muscle_twitch0.67013205
80MP0001542_abnormal_bone_strength0.66751346
81MP0002752_abnormal_somatic_nervous0.62935098
82MP0004134_abnormal_chest_morphology0.62264188
83MP0003279_aneurysm0.61196410
84MP0005220_abnormal_exocrine_pancreas0.61174603
85MP0002272_abnormal_nervous_system0.60481695
86MP0004885_abnormal_endolymph0.58330193
87MP0002127_abnormal_cardiovascular_syste0.56270195
88MP0004859_abnormal_synaptic_plasticity0.55578508
89MP0009745_abnormal_behavioral_response0.55130932
90MP0001958_emphysema0.53231130
91MP0005595_abnormal_vascular_smooth0.51756981
92MP0002928_abnormal_bile_duct0.50191301
93MP0001970_abnormal_pain_threshold0.49879567
94MP0001986_abnormal_taste_sensitivity0.49842093
95MP0005508_abnormal_skeleton_morphology0.49455699
96MP0001324_abnormal_eye_pigmentation0.48596297
97MP0002249_abnormal_larynx_morphology0.48162402
98MP0002693_abnormal_pancreas_physiology0.46352923
99MP0002168_other_aberrant_phenotype0.45902528
100MP0000462_abnormal_digestive_system0.45787397

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)7.77297498
2Abnormality of dentin (HP:0010299)7.52686242
3Asymmetry of the thorax (HP:0001555)5.87515357
4Fibular aplasia (HP:0002990)5.22263940
5Pili torti (HP:0003777)5.01914595
6Natal tooth (HP:0000695)4.74434349
7Palpebral edema (HP:0100540)4.68703692
8Decreased circulating renin level (HP:0003351)4.58509292
9Fibular hypoplasia (HP:0003038)4.13152862
10Hyperkalemia (HP:0002153)4.09533312
11Tracheomalacia (HP:0002779)4.05070809
12Congenital sensorineural hearing impairment (HP:0008527)3.91456280
13Abnormality of the dental pulp (HP:0006479)3.87830161
14Enlarged epiphyses (HP:0010580)3.86175218
15Mask-like facies (HP:0000298)3.70111354
16Thin bony cortex (HP:0002753)3.64504735
17Partial agenesis of the corpus callosum (HP:0001338)3.57417824
18Broad ribs (HP:0000885)3.55418669
19Abnormal trabecular bone morphology (HP:0100671)3.46744389
20Abnormality of chloride homeostasis (HP:0011422)3.43405336
21Abnormality of the lumbar spine (HP:0100712)3.43240181
22Bilateral microphthalmos (HP:0007633)3.40127095
23Abnormal hair laboratory examination (HP:0003328)3.34952116
24Thoracic kyphosis (HP:0002942)3.26401997
25Hyperactive renin-angiotensin system (HP:0000841)3.23958094
26Hypophosphatemic rickets (HP:0004912)3.22058552
27Aortic aneurysm (HP:0004942)3.10651826
28Abnormality of renin-angiotensin system (HP:0000847)3.03432328
29Hemorrhage of the eye (HP:0011885)2.99434518
30Distal lower limb amyotrophy (HP:0008944)2.99261557
31Delayed epiphyseal ossification (HP:0002663)2.93359830
32Tinnitus (HP:0000360)2.91406380
33Unilateral renal agenesis (HP:0000122)2.91167729
34Short nail (HP:0001799)2.90644987
35Patent foramen ovale (HP:0001655)2.86513492
36Delayed closure of the anterior fontanelle (HP:0001476)2.85177832
37Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.84423972
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.77699670
39Hypoplasia of the fovea (HP:0007750)2.77699670
40Widely patent fontanelles and sutures (HP:0004492)2.77566812
41Aplasia/Hypoplasia of the fibula (HP:0006492)2.76172084
42Mixed hearing impairment (HP:0000410)2.76039493
43Tibial bowing (HP:0002982)2.75005516
44Cystic liver disease (HP:0006706)2.74332851
45Duplicated collecting system (HP:0000081)2.73554722
46Anal stenosis (HP:0002025)2.65876460
47Bony spicule pigmentary retinopathy (HP:0007737)2.58371619
48Distal upper limb amyotrophy (HP:0007149)2.51141441
49Upper limb amyotrophy (HP:0009129)2.51141441
50Abnormality of the renal collecting system (HP:0004742)2.49954864
51Abnormality of the fibula (HP:0002991)2.48656403
52Attenuation of retinal blood vessels (HP:0007843)2.47431527
53Malnutrition (HP:0004395)2.47278854
54Ureteral duplication (HP:0000073)2.46925789
55Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.46583107
56Short 1st metacarpal (HP:0010034)2.46583107
57Thickened calvaria (HP:0002684)2.44626092
58Abnormality of the 1st metacarpal (HP:0010009)2.43810932
59Craniofacial hyperostosis (HP:0004493)2.41787418
60Aplasia/Hypoplasia of the macula (HP:0008059)2.41474716
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39652854
62Fused cervical vertebrae (HP:0002949)2.34690496
63Advanced eruption of teeth (HP:0006288)2.27550923
64Cerebral aneurysm (HP:0004944)2.26763549
65Periorbital edema (HP:0100539)2.25087140
66Aplasia/Hypoplasia affecting the retina (HP:0008061)2.24372234
67Zonular cataract (HP:0010920)2.20812348
68Rough bone trabeculation (HP:0100670)2.20629461
69Abnormality of potassium homeostasis (HP:0011042)2.20001260
70Abnormality of the costochondral junction (HP:0000919)2.19565379
71Lower limb amyotrophy (HP:0007210)2.17325490
72Follicular hyperkeratosis (HP:0007502)2.14900400
73Facial edema (HP:0000282)2.12961023
74Congenital, generalized hypertrichosis (HP:0004540)2.11384243
75Broad face (HP:0000283)2.10813615
76Aneurysm (HP:0002617)2.07382167
77Spinal muscular atrophy (HP:0007269)2.06674527
78Abnormality of the thoracic spine (HP:0100711)2.06577456
79Abnormality of the distal phalanges of the toes (HP:0010182)2.04743520
80Short phalanx of the thumb (HP:0009660)2.02691061
81Abnormality of the fovea (HP:0000493)2.01599536
82Chromsome breakage (HP:0040012)2.00821177
83Abnormality of DNA repair (HP:0003254)1.96724307
84Fragile skin (HP:0001030)1.95975957
85Neoplasm of the heart (HP:0100544)1.93219835
86Premature skin wrinkling (HP:0100678)1.91390699
87Pendular nystagmus (HP:0012043)1.90260073
88Nuclear cataract (HP:0100018)1.89299192
89Metaphyseal irregularity (HP:0003025)1.87949974
90Keratoconus (HP:0000563)1.86763894
91Increased corneal curvature (HP:0100692)1.86763894
92Cranial hyperostosis (HP:0004437)1.84318082
93Abnormality of pyrimidine metabolism (HP:0004353)1.83434835
94Femoral bowing (HP:0002980)1.79408473
95Urethral obstruction (HP:0000796)1.76429577
96Mildly elevated creatine phosphokinase (HP:0008180)1.74450836
97Decreased central vision (HP:0007663)1.72847218
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.71794063
99Squamous cell carcinoma (HP:0002860)1.71040340
100Wide anterior fontanel (HP:0000260)1.70429823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.91501748
2MST1R7.30058536
3NME14.68489991
4WNK13.36592547
5PRKG23.16748727
6SIK22.92313872
7MET2.84474577
8SIK12.82964244
9SIK32.50890809
10SMG12.08934205
11MELK1.72775356
12VRK21.70843800
13MAP2K61.67108988
14NEK21.62972370
15ICK1.62183029
16MUSK1.56407218
17ZAK1.50988773
18TAF11.35010774
19DDR21.29292092
20INSRR1.26207391
21CDK121.23975485
22HIPK21.19877836
23STK391.18164208
24LMTK21.10452663
25MAP3K91.00479526
26MAP4K20.97112448
27OXSR10.95896420
28PRKAA10.90321311
29BLK0.89674954
30MAPKAPK50.84607805
31ERN10.83222094
32MARK30.82159418
33PASK0.81410298
34FRK0.78788220
35MARK20.78318582
36ERBB20.73233465
37PRKAA20.67089615
38MAP3K70.65308450
39TEC0.63582083
40ITK0.62678212
41TNK20.62654114
42MAP3K60.62521768
43PRKCH0.61828010
44GRK50.61302986
45ADRBK20.60830215
46ACVR1B0.58736963
47CDK90.57944415
48FGFR40.55950362
49TESK20.55896385
50CDK190.55261001
51STK110.53748398
52TXK0.46805907
53PRKCG0.45272560
54MAP3K130.44165413
55CAMKK10.42917314
56GRK10.42402152
57NUAK10.40712178
58NLK0.40113697
59PINK10.39244676
60JAK30.39220936
61NTRK10.39105233
62TIE10.37779445
63PHKG20.37719500
64PHKG10.37719500
65KIT0.37679983
66TRIB30.36226491
67LCK0.34065812
68TRPM70.32315925
69HCK0.32121908
70BTK0.31470361
71MAP3K110.30028261
72MAP2K20.28488984
73SYK0.27268718
74PDK10.27261162
75DAPK10.25733964
76BMPR1B0.25215450
77PKN10.24306397
78SGK10.23397857
79PRKG10.22966168
80IGF1R0.22898184
81PRKCQ0.22815798
82PTK2B0.21792339
83PDPK10.21725946
84PIK3CA0.21578147
85CHEK20.21503679
86PDGFRB0.20300772
87CDC42BPA0.20101479
88CDK80.17697834
89CAMK2B0.17460061
90FGR0.17442412
91ATR0.17340594
92NEK10.17071429
93PRKD20.16707745
94PRKCB0.16697152
95CASK0.15474288
96PRKACA0.15117514
97PRKCA0.14821870
98PAK20.14469754
99RET0.14125846
100MAPK110.12882380

Predicted pathways (KEGG)

RankGene SetZ-score
1Salivary secretion_Homo sapiens_hsa049703.49861244
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.15109786
3Circadian entrainment_Homo sapiens_hsa047133.02816632
4Olfactory transduction_Homo sapiens_hsa047402.90702405
5ABC transporters_Homo sapiens_hsa020102.87493644
6Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.80836714
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36927300
8Aldosterone synthesis and secretion_Homo sapiens_hsa049252.32835700
9Morphine addiction_Homo sapiens_hsa050322.11083376
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.02139750
11Ovarian steroidogenesis_Homo sapiens_hsa049132.01809612
12Cholinergic synapse_Homo sapiens_hsa047251.89548207
13Phototransduction_Homo sapiens_hsa047441.87455078
14GABAergic synapse_Homo sapiens_hsa047271.86463463
15Oocyte meiosis_Homo sapiens_hsa041141.84958663
16Taste transduction_Homo sapiens_hsa047421.82799858
17Glutamatergic synapse_Homo sapiens_hsa047241.75584309
18Insulin secretion_Homo sapiens_hsa049111.73640615
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.70551307
20Glycerolipid metabolism_Homo sapiens_hsa005611.58061039
21Gastric acid secretion_Homo sapiens_hsa049711.56745032
22ECM-receptor interaction_Homo sapiens_hsa045121.53837540
23Protein digestion and absorption_Homo sapiens_hsa049741.46168439
24Linoleic acid metabolism_Homo sapiens_hsa005911.44157025
25Calcium signaling pathway_Homo sapiens_hsa040201.37097438
26Bile secretion_Homo sapiens_hsa049761.36053741
27Serotonergic synapse_Homo sapiens_hsa047261.34586903
28Nicotine addiction_Homo sapiens_hsa050331.33683410
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32787415
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31627249
31Fructose and mannose metabolism_Homo sapiens_hsa000511.30930049
32Retinol metabolism_Homo sapiens_hsa008301.29718301
33Thyroid hormone synthesis_Homo sapiens_hsa049181.23702632
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20861632
35Notch signaling pathway_Homo sapiens_hsa043301.20835280
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20445137
37Nitrogen metabolism_Homo sapiens_hsa009101.19040801
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18694880
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.13683374
40Platelet activation_Homo sapiens_hsa046111.12607581
41Dilated cardiomyopathy_Homo sapiens_hsa054141.11515217
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.09470817
43Renin secretion_Homo sapiens_hsa049241.08187924
44Pancreatic secretion_Homo sapiens_hsa049721.06864743
45cAMP signaling pathway_Homo sapiens_hsa040241.05827829
46Long-term depression_Homo sapiens_hsa047301.04763255
47Amoebiasis_Homo sapiens_hsa051461.04056172
48Caffeine metabolism_Homo sapiens_hsa002321.01569660
49Vibrio cholerae infection_Homo sapiens_hsa051101.01568133
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01294928
51Fanconi anemia pathway_Homo sapiens_hsa034600.96958673
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91648777
53Primary immunodeficiency_Homo sapiens_hsa053400.89380245
54Amphetamine addiction_Homo sapiens_hsa050310.89254651
55Arginine and proline metabolism_Homo sapiens_hsa003300.88362780
56Dorso-ventral axis formation_Homo sapiens_hsa043200.88221526
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86608367
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85163275
59One carbon pool by folate_Homo sapiens_hsa006700.84501470
60GnRH signaling pathway_Homo sapiens_hsa049120.81099753
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77644062
62Ether lipid metabolism_Homo sapiens_hsa005650.74680339
63Glucagon signaling pathway_Homo sapiens_hsa049220.70472090
64Gap junction_Homo sapiens_hsa045400.69863091
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.67116211
66Sphingolipid metabolism_Homo sapiens_hsa006000.66836167
67Chemical carcinogenesis_Homo sapiens_hsa052040.65287601
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.64702512
69Type II diabetes mellitus_Homo sapiens_hsa049300.64235659
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63810345
71Dopaminergic synapse_Homo sapiens_hsa047280.62770730
72African trypanosomiasis_Homo sapiens_hsa051430.61074865
73Mineral absorption_Homo sapiens_hsa049780.60841800
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56605939
75Arginine biosynthesis_Homo sapiens_hsa002200.54037033
76Cocaine addiction_Homo sapiens_hsa050300.48985018
77Fatty acid biosynthesis_Homo sapiens_hsa000610.48843044
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47056267
79Fat digestion and absorption_Homo sapiens_hsa049750.45853012
80Vitamin digestion and absorption_Homo sapiens_hsa049770.45309545
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45158521
82Small cell lung cancer_Homo sapiens_hsa052220.44972129
83Basal cell carcinoma_Homo sapiens_hsa052170.43681039
84Alcoholism_Homo sapiens_hsa050340.43575459
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42527226
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41868281
87Malaria_Homo sapiens_hsa051440.40236504
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.39326803
89Choline metabolism in cancer_Homo sapiens_hsa052310.38906904
90Arachidonic acid metabolism_Homo sapiens_hsa005900.38902495
91Oxytocin signaling pathway_Homo sapiens_hsa049210.37362619
92Ras signaling pathway_Homo sapiens_hsa040140.37295313
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.35531900
94Melanogenesis_Homo sapiens_hsa049160.33456474
95Systemic lupus erythematosus_Homo sapiens_hsa053220.32397928
96Pathways in cancer_Homo sapiens_hsa052000.32256041
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.31820727
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31351404
99Long-term potentiation_Homo sapiens_hsa047200.29008963
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27764214

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