USP17L11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to epidermal growth factor stimulus (GO:0071364)8.62805300
2O-glycan processing (GO:0016266)8.36971013
3regulation of ARF GTPase activity (GO:0032312)7.18314946
4response to epidermal growth factor (GO:0070849)6.81867865
5establishment of protein localization to Golgi (GO:0072600)5.88491718
6nephron tubule morphogenesis (GO:0072078)5.81612448
7nephron epithelium morphogenesis (GO:0072088)5.81612448
8protein O-linked glycosylation (GO:0006493)5.69356386
9C21-steroid hormone biosynthetic process (GO:0006700)5.68900056
10protein targeting to Golgi (GO:0000042)5.63479418
11retrograde transport, vesicle recycling within Golgi (GO:0000301)5.40736234
12negative regulation of digestive system process (GO:0060457)5.39576251
13phosphate ion homeostasis (GO:0055062)5.07622138
14trivalent inorganic anion homeostasis (GO:0072506)5.07622138
15glucocorticoid biosynthetic process (GO:0006704)4.88877439
16cellular response to glucocorticoid stimulus (GO:0071385)4.81326537
17cellular anion homeostasis (GO:0030002)4.68376067
18L-fucose catabolic process (GO:0042355)4.66167087
19fucose catabolic process (GO:0019317)4.66167087
20L-fucose metabolic process (GO:0042354)4.66167087
21striated muscle atrophy (GO:0014891)4.54786052
22renal tubule morphogenesis (GO:0061333)4.49644424
23cellular response to corticosteroid stimulus (GO:0071384)4.45353998
24phosphate ion transmembrane transport (GO:0035435)4.43990654
25protein localization to Golgi apparatus (GO:0034067)4.34937235
26membrane depolarization during action potential (GO:0086010)4.29784722
27positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.28558449
28digestive system process (GO:0022600)4.27030732
29cilium or flagellum-dependent cell motility (GO:0001539)4.26675732
30vocalization behavior (GO:0071625)4.24982407
31actin filament capping (GO:0051693)4.24592841
32regulation of acrosome reaction (GO:0060046)4.22385844
33auditory receptor cell stereocilium organization (GO:0060088)4.21788426
34skeletal muscle adaptation (GO:0043501)4.16533189
35muscle atrophy (GO:0014889)4.03276079
36renal absorption (GO:0070293)3.98973995
37fucosylation (GO:0036065)3.84895049
38phosphate ion transport (GO:0006817)3.82552605
39creatine metabolic process (GO:0006600)3.73187822
40negative regulation of actin filament depolymerization (GO:0030835)3.61512102
41myoblast fusion (GO:0007520)3.60392256
42photoreceptor cell maintenance (GO:0045494)3.55554539
43regulation of RIG-I signaling pathway (GO:0039535)3.50191399
44inner ear receptor cell differentiation (GO:0060113)3.49788640
45hair cell differentiation (GO:0035315)3.46872023
46dendritic spine morphogenesis (GO:0060997)3.39761253
47calcium ion import (GO:0070509)3.36541519
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.34705435
49syncytium formation (GO:0006949)3.34545207
50syncytium formation by plasma membrane fusion (GO:0000768)3.23843917
51cellular response to retinoic acid (GO:0071300)3.21238923
52regulation of cholesterol homeostasis (GO:2000188)3.13772086
53growth hormone secretion (GO:0030252)3.11170668
54dendritic spine organization (GO:0097061)3.10081051
55establishment of skin barrier (GO:0061436)3.08748720
56embryonic retina morphogenesis in camera-type eye (GO:0060059)2.98456812
57bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94956507
58Arp2/3 complex-mediated actin nucleation (GO:0034314)2.92478900
59actin nucleation (GO:0045010)2.90658212
60positive regulation of sodium ion transmembrane transport (GO:1902307)2.90079906
61regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.89431422
62auditory receptor cell differentiation (GO:0042491)2.88673572
63collecting duct development (GO:0072044)2.82785569
64membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.81364962
65inner ear receptor stereocilium organization (GO:0060122)2.81066922
66multicellular organismal water homeostasis (GO:0050891)2.80258445
67regulation of water loss via skin (GO:0033561)2.77467918
68extracellular fibril organization (GO:0043206)2.71566283
69detection of mechanical stimulus (GO:0050982)2.71096252
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.69448502
71histone H3-K9 demethylation (GO:0033169)2.68778570
72inositol metabolic process (GO:0006020)2.67814688
73neural tube development (GO:0021915)2.67495440
74epithelial cell fate commitment (GO:0072148)2.67392199
75mechanoreceptor differentiation (GO:0042490)2.67308710
76bone trabecula formation (GO:0060346)2.64784948
77negative regulation of myotube differentiation (GO:0010832)2.64290143
78regulation of hippo signaling (GO:0035330)2.63299375
79regulation of podosome assembly (GO:0071801)2.60824198
80glucocorticoid metabolic process (GO:0008211)2.59736421
81osteoblast development (GO:0002076)2.58220939
82C21-steroid hormone metabolic process (GO:0008207)2.55973558
83positive regulation of digestive system process (GO:0060456)2.54886634
84positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53370478
85lipoprotein metabolic process (GO:0042157)2.53010868
86striated muscle adaptation (GO:0014888)2.52444712
87macroautophagy (GO:0016236)2.51168669
88metanephric tubule development (GO:0072170)2.50876895
89metanephric nephron tubule development (GO:0072234)2.50876895
90glomerular basement membrane development (GO:0032836)2.49743271
91regulation of digestive system process (GO:0044058)2.48478993
92regulation of actin filament depolymerization (GO:0030834)2.47444429
93phospholipid scrambling (GO:0017121)2.45870710
94positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43806945
95GDP-mannose metabolic process (GO:0019673)2.42705440
96water homeostasis (GO:0030104)2.42170076
97maintenance of gastrointestinal epithelium (GO:0030277)15.1593097
98regulation of G0 to G1 transition (GO:0070316)14.3662871
99epithelial structure maintenance (GO:0010669)11.2034580
100response to vitamin A (GO:0033189)10.0348943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human6.21808763
2DROSHA_22980978_ChIP-Seq_HELA_Human5.26842716
3EZH2_22144423_ChIP-Seq_EOC_Human3.56667427
4GBX2_23144817_ChIP-Seq_PC3_Human3.32188499
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.07601878
6WDR5_24793694_ChIP-Seq_LNCAP_Human2.56715585
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53322976
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.42468272
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.22825852
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20472924
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20427259
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.14168116
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91080295
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89417766
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84813822
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77745950
17AR_21572438_ChIP-Seq_LNCaP_Human1.77737990
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.77541186
19SMC4_20622854_ChIP-Seq_HELA_Human1.69986621
20BCAT_22108803_ChIP-Seq_LS180_Human1.67667396
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66165383
22CTNNB1_20460455_ChIP-Seq_HCT116_Human1.56328422
23VDR_22108803_ChIP-Seq_LS180_Human1.54196660
24ER_23166858_ChIP-Seq_MCF-7_Human1.53845368
25GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53456007
26SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51745093
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.47522716
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.47424353
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.45626111
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43816228
31CTCF_27219007_Chip-Seq_Bcells_Human1.39692510
32NFYA_21822215_ChIP-Seq_K562_Human1.38910176
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.36877918
34KLF5_25053715_ChIP-Seq_YYC3_Human1.35301613
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33334324
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.33308398
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31255583
38AHR_22903824_ChIP-Seq_MCF-7_Human1.30644260
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29593036
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29064521
41STAT3_23295773_ChIP-Seq_U87_Human1.27949732
42E2F1_20622854_ChIP-Seq_HELA_Human1.27275062
43OCT4_20526341_ChIP-Seq_ESCs_Human1.23154673
44CDX2_22108803_ChIP-Seq_LS180_Human1.22134808
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.20452661
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19396737
47TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16782440
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.16410196
49CTCF_20526341_ChIP-Seq_ESCs_Human1.16042420
50BCL6_27268052_Chip-Seq_Bcells_Human1.15764855
51OCT4_19829295_ChIP-Seq_ESCs_Human1.14353320
52TCF4_23295773_ChIP-Seq_U87_Human1.13078920
53AR_19668381_ChIP-Seq_PC3_Human1.12931563
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10895512
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10592680
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10100181
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09713999
58SPI1_23127762_ChIP-Seq_K562_Human1.08949345
59TBL1_22424771_ChIP-Seq_293T_Human1.07676031
60TP53_16413492_ChIP-PET_HCT116_Human1.06662134
61GATA6_25053715_ChIP-Seq_YYC3_Human1.05854540
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03185432
63TCF4_22108803_ChIP-Seq_LS180_Human1.03006370
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02020609
65TP63_22573176_ChIP-Seq_HFKS_Human1.01967120
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00877288
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00119419
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98691836
69P68_20966046_ChIP-Seq_HELA_Human0.98187347
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98024790
71ARNT_22903824_ChIP-Seq_MCF-7_Human0.97251924
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96794101
73RACK7_27058665_Chip-Seq_MCF-7_Human0.96775249
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96606340
75GATA1_19941827_ChIP-Seq_MEL_Mouse0.96030113
76OCT1_27270436_Chip-Seq_PROSTATE_Human0.95960416
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95226569
78MYC_19915707_ChIP-ChIP_AK7_Human0.93893038
79MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93756512
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93295968
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93090264
82CBP_20019798_ChIP-Seq_JUKART_Human0.93090264
83NFYB_21822215_ChIP-Seq_K562_Human0.92787113
84ERA_21632823_ChIP-Seq_H3396_Human0.92369903
85NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92073263
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90115452
87BCOR_27268052_Chip-Seq_Bcells_Human0.89987771
88E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89916273
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89183912
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88998424
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.88597743
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88493359
93CBP_21632823_ChIP-Seq_H3396_Human0.88395849
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87776305
95WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87614989
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.87258529
97GATA4_25053715_ChIP-Seq_YYC3_Human0.87057932
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.86801549
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.86105907
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.85832107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000465_gastrointestinal_hemorrhage5.60338318
2MP0004043_abnormal_pH_regulation5.37457806
3MP0000579_abnormal_nail_morphology5.10351827
4MP0003879_abnormal_hair_cell4.65724896
5MP0003705_abnormal_hypodermis_morpholog3.70968368
6MP0005377_hearing/vestibular/ear_phenot3.36096446
7MP0003878_abnormal_ear_physiology3.36096446
8MP0002822_catalepsy3.35100114
9MP0003866_abnormal_defecation3.30767467
10MP0000566_synostosis3.16271771
11MP0005275_abnormal_skin_tensile3.06264936
12MP0008438_abnormal_cutaneous_collagen2.96275244
13MP0001666_abnormal_nutrient_absorption2.77975688
14MP0001485_abnormal_pinna_reflex2.70722046
15MP0008004_abnormal_stomach_pH2.20186343
16MP0001765_abnormal_ion_homeostasis2.19524403
17MP0001661_extended_life_span2.14301236
18MP0003091_abnormal_cell_migration2.01600814
19MP0003045_fibrosis1.97951478
20MP0001664_abnormal_digestion1.97011480
21MP0008057_abnormal_DNA_replication1.85051351
22MP0002138_abnormal_hepatobiliary_system1.80067960
23MP0004742_abnormal_vestibular_system1.76624875
24MP0000383_abnormal_hair_follicle1.76227671
25MP0003252_abnormal_bile_duct1.72701033
26MP0002060_abnormal_skin_morphology1.66953511
27MP0001663_abnormal_digestive_system1.62737072
28MP0005257_abnormal_intraocular_pressure1.49365887
29MP0005083_abnormal_biliary_tract1.47543232
30MP0010678_abnormal_skin_adnexa1.46747651
31MP0004019_abnormal_vitamin_homeostasis1.46321304
32MP0010234_abnormal_vibrissa_follicle1.43820130
33MP0005381_digestive/alimentary_phenotyp1.40278222
34MP0000026_abnormal_inner_ear1.38817163
35MP0003950_abnormal_plasma_membrane1.38514347
36MP0001963_abnormal_hearing_physiology1.37005479
37MP0000751_myopathy1.34814754
38MP0001243_abnormal_dermal_layer1.34293479
39MP0000749_muscle_degeneration1.32357009
40MP0003195_calcinosis1.31968596
41MP0000538_abnormal_urinary_bladder1.31716972
42MP0000427_abnormal_hair_cycle1.28577481
43MP0010155_abnormal_intestine_physiology1.28097624
44MP0003279_aneurysm1.23411662
45MP0002098_abnormal_vibrissa_morphology1.19348777
46MP0005551_abnormal_eye_electrophysiolog1.19144367
47MP0002249_abnormal_larynx_morphology1.13064016
48MP0002896_abnormal_bone_mineralization1.11877575
49MP0001501_abnormal_sleep_pattern1.03325860
50MP0002229_neurodegeneration1.02676604
51MP0009046_muscle_twitch1.02130512
52MP0000647_abnormal_sebaceous_gland0.99395171
53MP0010030_abnormal_orbit_morphology0.99348262
54MP0008995_early_reproductive_senescence0.99229504
55MP0001958_emphysema0.98008009
56MP0002735_abnormal_chemical_nociception0.97993196
57MP0002928_abnormal_bile_duct0.92534462
58MP0000747_muscle_weakness0.92363717
59MP0002269_muscular_atrophy0.89892656
60MP0003283_abnormal_digestive_organ0.86094814
61MP0001348_abnormal_lacrimal_gland0.85846199
62MP0010386_abnormal_urinary_bladder0.83253193
63MP0001542_abnormal_bone_strength0.82831801
64MP0010771_integument_phenotype0.77196666
65MP0005310_abnormal_salivary_gland0.74945743
66MP0002168_other_aberrant_phenotype0.73478726
67MP0000371_diluted_coat_color0.72813045
68MP0002733_abnormal_thermal_nociception0.71685188
69MP0001502_abnormal_circadian_rhythm0.71117321
70MP0010094_abnormal_chromosome_stability0.66871563
71MP0004147_increased_porphyrin_level0.66675944
72MP0004145_abnormal_muscle_electrophysio0.66352320
73MP0002136_abnormal_kidney_physiology0.65688106
74MP0001849_ear_inflammation0.64989432
75MP0004264_abnormal_extraembryonic_tissu0.63988833
76MP0005076_abnormal_cell_differentiation0.63502657
77MP0001270_distended_abdomen0.63023006
78MP0003646_muscle_fatigue0.61430180
79MP0002272_abnormal_nervous_system0.61392590
80MP0000230_abnormal_systemic_arterial0.60410055
81MP0000470_abnormal_stomach_morphology0.59504946
82MP0004924_abnormal_behavior0.57995701
83MP0005386_behavior/neurological_phenoty0.57995701
84MP0002075_abnormal_coat/hair_pigmentati0.56319793
85MP0000477_abnormal_intestine_morphology0.55689757
86MP0002127_abnormal_cardiovascular_syste0.54006013
87MP0002067_abnormal_sensory_capabilities0.53636641
88MP0003786_premature_aging0.52706156
89MP0005670_abnormal_white_adipose0.52238048
90MP0004859_abnormal_synaptic_plasticity0.51747121
91MP0000432_abnormal_head_morphology0.51593848
92MP0003183_abnormal_peptide_metabolism0.51295342
93MP0002752_abnormal_somatic_nervous0.50930186
94MP0004036_abnormal_muscle_relaxation0.50238360
95MP0001756_abnormal_urination0.49097994
96MP0005501_abnormal_skin_physiology0.47235531
97MP0005508_abnormal_skeleton_morphology0.46932415
98MP0005266_abnormal_metabolism0.46222496
99MP0005636_abnormal_mineral_homeostasis0.45953624
100MP0003943_abnormal_hepatobiliary_system0.44318926

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)6.15812662
2Palpebral edema (HP:0100540)5.61281185
3Congenital sensorineural hearing impairment (HP:0008527)5.34434826
4Bilateral sensorineural hearing impairment (HP:0008619)5.32736088
5Abnormality of dentin (HP:0010299)5.32417640
6Thin bony cortex (HP:0002753)5.01731613
7Hyperkalemia (HP:0002153)4.76565498
8Enlarged epiphyses (HP:0010580)4.67147876
9Mask-like facies (HP:0000298)4.63776964
10Hypophosphatemic rickets (HP:0004912)4.26638470
11Hemorrhage of the eye (HP:0011885)4.03414774
12Abnormal hair laboratory examination (HP:0003328)4.02578226
13Abnormality of chloride homeostasis (HP:0011422)3.84966452
14Tibial bowing (HP:0002982)3.78391257
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75029302
16Delayed epiphyseal ossification (HP:0002663)3.72624470
17Distal lower limb amyotrophy (HP:0008944)3.68238811
18Cerebral aneurysm (HP:0004944)3.67285003
19Distal upper limb amyotrophy (HP:0007149)3.61568534
20Upper limb amyotrophy (HP:0009129)3.61568534
21Duplicated collecting system (HP:0000081)3.31656176
22Urethral obstruction (HP:0000796)3.30269712
23Chromsome breakage (HP:0040012)3.27784046
24Malnutrition (HP:0004395)3.22675656
25Broad face (HP:0000283)3.17228384
26Mildly elevated creatine phosphokinase (HP:0008180)3.02525878
27Nuclear cataract (HP:0100018)2.99029927
28Ureteral duplication (HP:0000073)2.97204216
29Fragile skin (HP:0001030)2.97037556
30Short 1st metacarpal (HP:0010034)2.91677620
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.91677620
32Abnormality of DNA repair (HP:0003254)2.89652406
33Abnormality of the 1st metacarpal (HP:0010009)2.86313099
34Widely patent fontanelles and sutures (HP:0004492)2.85938431
35Abnormality of pyrimidine metabolism (HP:0004353)2.81967059
36Abnormality of the renal collecting system (HP:0004742)2.80181405
37Spinal muscular atrophy (HP:0007269)2.78624068
38Abnormality of the costochondral junction (HP:0000919)2.78466449
39Periorbital edema (HP:0100539)2.67444254
40Abnormality of the distal phalanges of the toes (HP:0010182)2.63631448
41Hyperactive renin-angiotensin system (HP:0000841)2.60318226
42Lower limb amyotrophy (HP:0007210)2.60070912
43Cystic liver disease (HP:0006706)2.59490830
44Atrophic scars (HP:0001075)2.58673880
45Facial edema (HP:0000282)2.56621675
46Ectopic kidney (HP:0000086)2.56618951
47Bony spicule pigmentary retinopathy (HP:0007737)2.52271426
48Follicular hyperkeratosis (HP:0007502)2.50226308
49Broad metatarsal (HP:0001783)2.49292599
50Short nail (HP:0001799)2.47605211
51Neonatal short-limb short stature (HP:0008921)2.43802272
52Short phalanx of the thumb (HP:0009660)2.42690516
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.42610328
54Patent foramen ovale (HP:0001655)2.41899682
55Increased connective tissue (HP:0009025)2.34043806
56Difficulty walking (HP:0002355)2.32861803
57Increased corneal curvature (HP:0100692)2.26715076
58Keratoconus (HP:0000563)2.26715076
59Duplication of thumb phalanx (HP:0009942)2.25222441
60Milia (HP:0001056)2.23987730
61Bronchomalacia (HP:0002780)2.21793765
62Premature rupture of membranes (HP:0001788)2.19451036
63Attenuation of retinal blood vessels (HP:0007843)2.15290598
64Hyperacusis (HP:0010780)2.12613435
65Onion bulb formation (HP:0003383)2.11640947
66Self-mutilation (HP:0000742)2.10929292
67Hand muscle atrophy (HP:0009130)2.07716817
68Abnormality of the dental pulp (HP:0006479)2.06784675
69Axonal loss (HP:0003447)2.05043485
70Abnormal trabecular bone morphology (HP:0100671)2.04893068
71Abnormality of the carotid arteries (HP:0005344)2.04773773
72Difficulty climbing stairs (HP:0003551)2.03874411
73Premature skin wrinkling (HP:0100678)2.03223139
74Severe visual impairment (HP:0001141)1.97827414
75Abnormality of the preputium (HP:0100587)1.97250208
76Aortic dissection (HP:0002647)1.97176595
77Abnormality of potassium homeostasis (HP:0011042)1.97154651
78Morphological abnormality of the middle ear (HP:0008609)1.95369951
79Male infertility (HP:0003251)1.93632860
80Decreased circulating renin level (HP:0003351)1.91965677
81Femoral bowing (HP:0002980)1.91391886
82Flat occiput (HP:0005469)1.91099227
83Pendular nystagmus (HP:0012043)1.87736344
84Aneurysm (HP:0002617)1.86324896
85Progressive sensorineural hearing impairment (HP:0000408)1.82919833
86Wide cranial sutures (HP:0010537)1.82784144
87Abnormality of renin-angiotensin system (HP:0000847)1.81923534
88Abnormality of the ileum (HP:0001549)1.81629173
89Tracheomalacia (HP:0002779)1.77812781
90Long eyelashes (HP:0000527)1.77491196
91Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.76423741
92Soft skin (HP:0000977)1.76274006
93Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75926453
94Meckel diverticulum (HP:0002245)1.75258263
95Metaphyseal irregularity (HP:0003025)1.75223392
96Spondylolisthesis (HP:0003302)1.74064768
97Bladder diverticulum (HP:0000015)1.72576911
98Mitral valve prolapse (HP:0001634)1.72027429
99Mild short stature (HP:0003502)1.71858645
100Rickets (HP:0002748)1.70158123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.78032861
2WNK48.42452298
3NME15.85672606
4MET3.56408535
5WNK13.45144218
6CDK122.75017029
7FRK2.54777716
8MUSK1.74665708
9LMTK21.74224511
10NEK21.59812500
11MAP3K131.49132605
12MAP2K61.46233858
13STK391.44218791
14DDR21.31733543
15INSRR1.24080254
16BLK1.23267160
17SIK21.22548263
18SIK11.16090889
19ACVR1B1.15055453
20TRIB31.06978982
21MAP4K21.03482812
22ERN10.98679575
23ERBB20.96675797
24MAP3K70.96608893
25CAMK1D0.85420893
26TNIK0.77930653
27MAP3K90.75502685
28OXSR10.72476149
29PRKCH0.71935232
30BRD40.69231723
31CAMK1G0.68109603
32MTOR0.64613419
33PIK3CG0.63579894
34MARK20.63005055
35TNK20.62922117
36FGFR40.61974834
37TRPM70.57140912
38SGK10.55810703
39MAP3K60.55579804
40PHKG20.54350092
41PHKG10.54350092
42ICK0.52604357
43NTRK10.51369867
44PDGFRB0.49828109
45CDC42BPA0.46983396
46PRKAA20.46923100
47CDK90.41559345
48BMPR1B0.40885683
49MKNK10.40215546
50RIPK10.39660939
51PRKAA10.39158979
52MELK0.36351894
53ZAK0.36177671
54TEC0.34350775
55RET0.34345146
56CASK0.34030260
57MAPK110.33006108
58PTK2B0.32375173
59PRKD20.32203902
60PRKG20.32153733
61PIK3CA0.30420977
62PASK0.27140587
63PDK10.26507976
64MAP2K20.25711455
65EPHA20.24879127
66FER0.23690989
67MAPK10.21989488
68AKT10.21313503
69CSF1R0.21260604
70ATR0.20598144
71TAOK10.20570035
72PDGFRA0.19733994
73RPS6KA60.19327268
74FES0.19158067
75PKN20.19153335
76ITK0.17306225
77RPS6KA30.16867869
78CHEK10.16829689
79KIT0.16699336
80MKNK20.16406786
81GSK3B0.16262713
82PDPK10.15903734
83CAMK2B0.15769724
84FGFR20.14578703
85RPS6KA20.14492457
86IGF1R0.14489262
87TAOK20.14443638
88CHUK0.14396204
89ADRBK10.13966947
90PRKDC0.13582109
91MAPK30.13112634
92CDK10.12881319
93FYN0.12333832
94BTK0.11956253
95SRC0.11614323
96RPS6KL10.10705630
97RPS6KC10.10705630
98BRAF0.10385516
99CAMKK10.09799618
100AKT30.09245025

Predicted pathways (KEGG)

RankGene SetZ-score
1Progesterone-mediated oocyte maturation_Homo sapiens_hsa049144.07831140
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.94755968
3Salivary secretion_Homo sapiens_hsa049703.42867812
4ABC transporters_Homo sapiens_hsa020103.16348344
5Oocyte meiosis_Homo sapiens_hsa041142.84227768
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42993382
7Vibrio cholerae infection_Homo sapiens_hsa051102.34065738
8ECM-receptor interaction_Homo sapiens_hsa045122.16834470
9Aldosterone synthesis and secretion_Homo sapiens_hsa049252.14017683
10Fructose and mannose metabolism_Homo sapiens_hsa000511.97908477
11Protein digestion and absorption_Homo sapiens_hsa049741.97752025
12Ovarian steroidogenesis_Homo sapiens_hsa049131.95508172
13Amoebiasis_Homo sapiens_hsa051461.81239598
14Fanconi anemia pathway_Homo sapiens_hsa034601.69317656
15Circadian entrainment_Homo sapiens_hsa047131.68361153
16Taste transduction_Homo sapiens_hsa047421.62623547
17Olfactory transduction_Homo sapiens_hsa047401.61144644
18Lysine degradation_Homo sapiens_hsa003101.56282092
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.54179404
20Insulin secretion_Homo sapiens_hsa049111.54058883
21Gastric acid secretion_Homo sapiens_hsa049711.51842753
22Thyroid hormone synthesis_Homo sapiens_hsa049181.45536148
23Bile secretion_Homo sapiens_hsa049761.41792486
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.35748398
25Arginine and proline metabolism_Homo sapiens_hsa003301.34929092
26Pancreatic secretion_Homo sapiens_hsa049721.29566772
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24190057
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18304052
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16910781
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12637834
31Glycerolipid metabolism_Homo sapiens_hsa005611.11428801
32Calcium signaling pathway_Homo sapiens_hsa040201.09834702
33Nitrogen metabolism_Homo sapiens_hsa009101.05923949
34Other glycan degradation_Homo sapiens_hsa005111.05068354
35Glutamatergic synapse_Homo sapiens_hsa047241.03570522
36GnRH signaling pathway_Homo sapiens_hsa049121.03204471
37Cholinergic synapse_Homo sapiens_hsa047250.96615655
38Dilated cardiomyopathy_Homo sapiens_hsa054140.96145119
39Platelet activation_Homo sapiens_hsa046110.93768945
40Arginine biosynthesis_Homo sapiens_hsa002200.92980855
41Dorso-ventral axis formation_Homo sapiens_hsa043200.92921458
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89647755
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87801448
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87748549
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86603101
46Serotonergic synapse_Homo sapiens_hsa047260.84627155
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.83325788
48Notch signaling pathway_Homo sapiens_hsa043300.79726145
49Homologous recombination_Homo sapiens_hsa034400.79357715
50Morphine addiction_Homo sapiens_hsa050320.77891752
51cAMP signaling pathway_Homo sapiens_hsa040240.77712039
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76864902
53Inositol phosphate metabolism_Homo sapiens_hsa005620.76643004
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74770115
55Long-term potentiation_Homo sapiens_hsa047200.74035706
56Type II diabetes mellitus_Homo sapiens_hsa049300.72914471
57Linoleic acid metabolism_Homo sapiens_hsa005910.72254204
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.71948881
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70958262
60Focal adhesion_Homo sapiens_hsa045100.70157592
61Nicotine addiction_Homo sapiens_hsa050330.68411720
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.67177576
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.67027561
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66356422
65Chemical carcinogenesis_Homo sapiens_hsa052040.65850541
66Phototransduction_Homo sapiens_hsa047440.62244392
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61461314
68Tight junction_Homo sapiens_hsa045300.61289625
69Estrogen signaling pathway_Homo sapiens_hsa049150.60021339
70Tryptophan metabolism_Homo sapiens_hsa003800.59282073
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59257506
72Long-term depression_Homo sapiens_hsa047300.58533131
73Fatty acid biosynthesis_Homo sapiens_hsa000610.58376815
74Choline metabolism in cancer_Homo sapiens_hsa052310.58151622
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57800218
76Glucagon signaling pathway_Homo sapiens_hsa049220.55595888
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55203866
78GABAergic synapse_Homo sapiens_hsa047270.54762899
79Renin secretion_Homo sapiens_hsa049240.53463330
80Mineral absorption_Homo sapiens_hsa049780.50305917
81Cocaine addiction_Homo sapiens_hsa050300.49027075
82Systemic lupus erythematosus_Homo sapiens_hsa053220.46685328
83Retinol metabolism_Homo sapiens_hsa008300.44471036
84Galactose metabolism_Homo sapiens_hsa000520.44421076
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41286789
86Gap junction_Homo sapiens_hsa045400.40787955
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39998898
88Starch and sucrose metabolism_Homo sapiens_hsa005000.38868588
89One carbon pool by folate_Homo sapiens_hsa006700.37932021
90Oxytocin signaling pathway_Homo sapiens_hsa049210.37928687
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.37102236
92Amphetamine addiction_Homo sapiens_hsa050310.35430178
93Butanoate metabolism_Homo sapiens_hsa006500.35203601
94Insulin resistance_Homo sapiens_hsa049310.34308535
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34023241
96Small cell lung cancer_Homo sapiens_hsa052220.33749061
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32204091
98Adherens junction_Homo sapiens_hsa045200.31224337
99Ether lipid metabolism_Homo sapiens_hsa005650.29246496
100Purine metabolism_Homo sapiens_hsa002300.25186244

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