USP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)4.30369584
2histone H2B ubiquitination (GO:0033523)4.15916381
3response to redox state (GO:0051775)4.14761169
4ER overload response (GO:0006983)4.05270759
5snRNA transcription (GO:0009301)4.03065684
6kinetochore organization (GO:0051383)3.94644833
7mitotic metaphase plate congression (GO:0007080)3.84476277
8transcription elongation from RNA polymerase III promoter (GO:0006385)3.71502306
9termination of RNA polymerase III transcription (GO:0006386)3.71502306
10meiotic chromosome segregation (GO:0045132)3.64216181
11protein K11-linked deubiquitination (GO:0035871)3.62518532
12nuclear pore organization (GO:0006999)3.61001348
13CENP-A containing nucleosome assembly (GO:0034080)3.60457775
14chromatin remodeling at centromere (GO:0031055)3.59387751
15sphingosine metabolic process (GO:0006670)3.57188352
16RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.53064500
17somatic hypermutation of immunoglobulin genes (GO:0016446)3.41219214
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41219214
19nuclear pore complex assembly (GO:0051292)3.40100943
20negative regulation of neurotransmitter secretion (GO:0046929)3.37933421
21piRNA metabolic process (GO:0034587)3.37801638
22transcription elongation from RNA polymerase I promoter (GO:0006362)3.37548864
23regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.35363648
24male meiosis I (GO:0007141)3.34478454
25kinetochore assembly (GO:0051382)3.34122552
26regulation of establishment of cell polarity (GO:2000114)3.31894372
27termination of RNA polymerase I transcription (GO:0006363)3.31792388
28regulation of RNA export from nucleus (GO:0046831)3.29522680
29somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.28383362
30isotype switching (GO:0045190)3.28383362
31somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.28383362
32regulation of DNA endoreduplication (GO:0032875)3.26103661
33nucleotide transmembrane transport (GO:1901679)3.20894717
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18119403
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17894098
36non-recombinational repair (GO:0000726)3.17847683
37double-strand break repair via nonhomologous end joining (GO:0006303)3.17847683
38diol metabolic process (GO:0034311)3.16303034
39male meiosis (GO:0007140)3.15844969
40mitotic G2/M transition checkpoint (GO:0044818)3.15539707
41organelle disassembly (GO:1903008)3.12215349
42protein neddylation (GO:0045116)3.12067285
43protein K6-linked ubiquitination (GO:0085020)3.11073443
44replication fork processing (GO:0031297)3.09250321
45resolution of meiotic recombination intermediates (GO:0000712)3.09143373
46* monoubiquitinated protein deubiquitination (GO:0035520)3.08939146
47cellular response to gamma radiation (GO:0071480)3.07720635
48positive regulation of mRNA 3-end processing (GO:0031442)3.07661517
49central nervous system myelination (GO:0022010)3.06704800
50axon ensheathment in central nervous system (GO:0032291)3.06704800
51tolerance induction (GO:0002507)3.06178548
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04899418
53meiosis I (GO:0007127)3.02851753
54ribonucleoprotein complex disassembly (GO:0032988)3.02424899
55DNA-templated transcription, elongation (GO:0006354)3.02154784
56positive regulation of gamma-delta T cell activation (GO:0046645)3.01917558
57double-strand break repair via homologous recombination (GO:0000724)3.00770419
58negative regulation of keratinocyte proliferation (GO:0010839)3.00414600
59DNA damage induced protein phosphorylation (GO:0006975)3.00056652
60vitamin transmembrane transport (GO:0035461)2.99955672
61transcription from RNA polymerase I promoter (GO:0006360)2.99865179
62metaphase plate congression (GO:0051310)2.99803823
63proteasome assembly (GO:0043248)2.99654275
64transcription elongation from RNA polymerase II promoter (GO:0006368)2.99499962
65histone mRNA metabolic process (GO:0008334)2.99269745
66protein prenylation (GO:0018342)2.98969877
67prenylation (GO:0097354)2.98969877
68transcription initiation from RNA polymerase I promoter (GO:0006361)2.98580695
69negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.98054310
70centriole assembly (GO:0098534)2.97428903
71pyrimidine-containing compound transmembrane transport (GO:0072531)2.97174120
72recombinational repair (GO:0000725)2.94477035
73interferon-gamma production (GO:0032609)2.94221710
74type B pancreatic cell development (GO:0003323)2.94194599
75RNA capping (GO:0036260)2.94075892
767-methylguanosine RNA capping (GO:0009452)2.94075892
77histone exchange (GO:0043486)2.93910005
78peptidyl-histidine modification (GO:0018202)2.93409033
79regulation of centriole replication (GO:0046599)2.92840584
80ribosomal large subunit biogenesis (GO:0042273)2.92032053
81synapsis (GO:0007129)2.91928959
82negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.91329227
83negative regulation of DNA-templated transcription, elongation (GO:0032785)2.91329227
84positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.90097860
85regulation of spindle organization (GO:0090224)2.90011708
867-methylguanosine mRNA capping (GO:0006370)2.88935719
87microtubule depolymerization (GO:0007019)2.88707703
88blastocyst development (GO:0001824)2.86426817
89multicellular organism reproduction (GO:0032504)2.82716766
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82376211
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82376211
92positive regulation of mitotic sister chromatid separation (GO:1901970)2.82376211
93regulation of mitotic spindle checkpoint (GO:1903504)2.82044520
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82044520
95regulation of establishment or maintenance of cell polarity (GO:0032878)2.80709072
96columnar/cuboidal epithelial cell development (GO:0002066)2.80704014
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80534426
98regulation of mRNA 3-end processing (GO:0031440)2.77439096
99DNA methylation involved in gamete generation (GO:0043046)2.76680948
100sphingoid metabolic process (GO:0046519)2.76115153
101DNA double-strand break processing (GO:0000729)2.76012243
102regulation of transcription from RNA polymerase I promoter (GO:0006356)2.74245311
103regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.74140519
104female gonad development (GO:0008585)2.73684752
105negative regulation of inclusion body assembly (GO:0090084)2.72839790
106cullin deneddylation (GO:0010388)2.71640374
107negative regulation of T cell differentiation in thymus (GO:0033085)2.71277791
108mitochondrial respiratory chain complex assembly (GO:0033108)2.70804922
109magnesium ion transport (GO:0015693)2.70750437
110ribosome assembly (GO:0042255)2.70542467
111lactate metabolic process (GO:0006089)2.70343875
112centrosome duplication (GO:0051298)2.69584287
113attachment of spindle microtubules to kinetochore (GO:0008608)2.69554867
114negative regulation of DNA recombination (GO:0045910)2.68121265
115meiotic cell cycle (GO:0051321)2.67822760
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.67421002
117ATP synthesis coupled proton transport (GO:0015986)2.67421002
118protein complex biogenesis (GO:0070271)2.67171901
119histone mRNA catabolic process (GO:0071044)2.66781980
120somatic recombination of immunoglobulin gene segments (GO:0016447)2.64841351
121transcription from RNA polymerase III promoter (GO:0006383)2.64479550
122fusion of sperm to egg plasma membrane (GO:0007342)2.64258997
123mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63650302
124COPII vesicle coating (GO:0048208)2.62325916
125signal peptide processing (GO:0006465)2.60485841
126DNA ligation (GO:0006266)2.59330596
127rRNA modification (GO:0000154)2.59063520
128regulation of exit from mitosis (GO:0007096)2.58997307
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58772594
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.58772594
131NADH dehydrogenase complex assembly (GO:0010257)2.58772594
132DNA replication checkpoint (GO:0000076)2.58677493
133regulation of nucleobase-containing compound transport (GO:0032239)2.58439115
134endocrine pancreas development (GO:0031018)2.58121193
135N-terminal protein amino acid modification (GO:0031365)2.58060216
136DNA replication-independent nucleosome organization (GO:0034724)2.57750293
137DNA replication-independent nucleosome assembly (GO:0006336)2.57750293
138rRNA methylation (GO:0031167)2.56847398
139response to X-ray (GO:0010165)2.56718570
140regulation of keratinocyte proliferation (GO:0010837)2.56708534
141positive regulation of chromosome segregation (GO:0051984)2.56424174
142negative regulation of cell cycle G2/M phase transition (GO:1902750)2.55937130
143inner cell mass cell proliferation (GO:0001833)2.55505504
144sister chromatid cohesion (GO:0007062)2.55252024
145eye photoreceptor cell differentiation (GO:0001754)2.54826788
146photoreceptor cell differentiation (GO:0046530)2.54826788
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.54669072
148nucleotide-sugar biosynthetic process (GO:0009226)2.54227204
149myoblast migration (GO:0051451)2.53107070
150centrosome organization (GO:0051297)2.52299616
151positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.52233167
152protein deneddylation (GO:0000338)2.52075249
153formation of translation preinitiation complex (GO:0001731)2.52035820
154negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51912880
155pore complex assembly (GO:0046931)2.51860702
156mitotic sister chromatid cohesion (GO:0007064)2.51771347
157establishment of chromosome localization (GO:0051303)2.50951097
158mitotic G2 DNA damage checkpoint (GO:0007095)2.50171944
159regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.49915821
160B cell activation involved in immune response (GO:0002312)2.49386335
161glycerophospholipid catabolic process (GO:0046475)2.48881068
162anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.48742961
163regulation of mitotic metaphase/anaphase transition (GO:0030071)2.48673201
164regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.48673201
165negative regulation of DNA repair (GO:0045738)2.48327230
166somatic diversification of immunoglobulins (GO:0016445)2.48293175
167centriole replication (GO:0007099)2.46952485
168double-strand break repair (GO:0006302)2.46643603
169regulation of keratinocyte differentiation (GO:0045616)2.46052725
170spindle checkpoint (GO:0031577)2.45655883
171nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.45608704
172regulation of spindle checkpoint (GO:0090231)2.45571157
173cilium or flagellum-dependent cell motility (GO:0001539)2.44527401
174positive regulation of insulin receptor signaling pathway (GO:0046628)2.43358431
175mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.43204516
176positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.43204516
177regulation of meiosis I (GO:0060631)2.42417336
178negative regulation of myoblast differentiation (GO:0045662)2.41329330
179mitotic cell cycle arrest (GO:0071850)2.41239389
180microtubule polymerization or depolymerization (GO:0031109)2.40991987
181regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.39678972
182N-terminal protein amino acid acetylation (GO:0006474)2.38828684
183synaptonemal complex assembly (GO:0007130)2.38299657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.41969578
2E2F7_22180533_ChIP-Seq_HELA_Human3.63079207
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13794328
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88758011
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.86556835
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51933542
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50056569
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49972963
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46098251
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.21610717
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18249663
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.07654724
13SUZ12_27294783_Chip-Seq_NPCs_Mouse1.99728199
14SMAD_19615063_ChIP-ChIP_OVARY_Human1.99139793
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95154100
16TAF15_26573619_Chip-Seq_HEK293_Human1.91394712
17FOXP3_21729870_ChIP-Seq_TREG_Human1.85713912
18NFE2_27457419_Chip-Seq_LIVER_Mouse1.84625791
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.83609215
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81569340
21NANOG_18555785_Chip-Seq_ESCs_Mouse1.81155527
22KAP1_22055183_ChIP-Seq_ESCs_Mouse1.81125343
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81012707
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.78627589
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.75006442
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74944249
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71071618
28* ETS1_20019798_ChIP-Seq_JURKAT_Human1.70587488
29ELK1_19687146_ChIP-ChIP_HELA_Human1.67968691
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64608184
31ZNF274_21170338_ChIP-Seq_K562_Hela1.63800912
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63061318
33IGF1R_20145208_ChIP-Seq_DFB_Human1.62716844
34EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.62162209
35EWS_26573619_Chip-Seq_HEK293_Human1.61492642
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61344133
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60737694
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59938522
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.58876627
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57661388
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53383332
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53281064
43LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52970968
44STAT3_18555785_Chip-Seq_ESCs_Mouse1.52625850
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50670258
46P53_22387025_ChIP-Seq_ESCs_Mouse1.50062715
47FUS_26573619_Chip-Seq_HEK293_Human1.49514684
48VDR_23849224_ChIP-Seq_CD4+_Human1.49214646
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49042720
50NMYC_18555785_Chip-Seq_ESCs_Mouse1.48214940
51CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.47662395
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47424246
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.46372434
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45949217
55ER_23166858_ChIP-Seq_MCF-7_Human1.42977048
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.41259327
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40924702
58EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40051458
59* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39279531
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.37320819
61SOX2_18555785_Chip-Seq_ESCs_Mouse1.37241729
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.36176569
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35682138
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.34147410
65P300_18555785_Chip-Seq_ESCs_Mouse1.32108456
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31204801
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30907212
68MYC_18940864_ChIP-ChIP_HL60_Human1.30890595
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30747690
70IRF1_19129219_ChIP-ChIP_H3396_Human1.30372407
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.30322461
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.29776967
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26284880
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25210515
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25209997
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25069230
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24672939
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.23343824
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22926274
80P300_19829295_ChIP-Seq_ESCs_Human1.22221537
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.21744661
82SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21487091
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21384661
84* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20127909
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19306881
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18008149
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16265760
88CBP_20019798_ChIP-Seq_JUKART_Human1.16155687
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16155687
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15742992
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15043999
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12478388
93CDX2_22108803_ChIP-Seq_LS180_Human1.12097218
94PU1_27457419_Chip-Seq_LIVER_Mouse1.12089310
95VDR_22108803_ChIP-Seq_LS180_Human1.11782440
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.11070636
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10780849
98* EST1_17652178_ChIP-ChIP_JURKAT_Human1.10081051
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09775042
100SALL4_22934838_ChIP-ChIP_CD34+_Human1.09612853
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09038809
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07112210
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.06936137
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06669003
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06436784
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06431972
107DCP1A_22483619_ChIP-Seq_HELA_Human1.06262194
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05553974
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04372121
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.03907959
111PHF8_20622853_ChIP-Seq_HELA_Human1.03129922
112CTCF_18555785_Chip-Seq_ESCs_Mouse1.02939887
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02416607
114MYB_26560356_Chip-Seq_TH2_Human1.02350535
115AR_21909140_ChIP-Seq_LNCAP_Human1.02099561
116TBL1_22424771_ChIP-Seq_293T_Human1.01592990
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00494479
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99851920
119* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99692606
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.99252490
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97284313
122NFYA_21822215_ChIP-Seq_K562_Human0.96638943
123STAT3_23295773_ChIP-Seq_U87_Human0.96220333
124NFYB_21822215_ChIP-Seq_K562_Human0.95670238
125CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95586603
126KDM5A_27292631_Chip-Seq_BREAST_Human0.95573646
127ETV1_20927104_ChIP-Seq_GIST48_Human0.94985907
128CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94615349
129HNFA_21074721_ChIP-Seq_CACO-2_Human0.93877838
130GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93395249
131TTF2_22483619_ChIP-Seq_HELA_Human0.93293686
132FOXA1_25329375_ChIP-Seq_VCAP_Human0.92653599
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92653599
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92555235
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92223236
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92223236
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90818442
138GABP_19822575_ChIP-Seq_HepG2_Human0.90120291
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88606564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.99184536
2MP0005451_abnormal_body_composition4.05238062
3MP0005075_abnormal_melanosome_morpholog3.47099149
4MP0008057_abnormal_DNA_replication3.41839470
5MP0003693_abnormal_embryo_hatching3.14696052
6MP0000566_synostosis3.02624090
7MP0005257_abnormal_intraocular_pressure2.53000748
8MP0005310_abnormal_salivary_gland2.38369150
9MP0003763_abnormal_thymus_physiology2.31662758
10MP0005408_hypopigmentation2.31180191
11MP0003718_maternal_effect2.28546706
12MP0008877_abnormal_DNA_methylation2.12655352
13MP0002163_abnormal_gland_morphology2.11354446
14MP0000383_abnormal_hair_follicle2.08406958
15MP0005379_endocrine/exocrine_gland_phen2.05589544
16MP0003252_abnormal_bile_duct2.05462870
17MP0001299_abnormal_eye_distance/2.00259444
18MP0002009_preneoplasia1.99970752
19MP0001346_abnormal_lacrimal_gland1.99864862
20MP0003937_abnormal_limbs/digits/tail_de1.90100267
21MP0002877_abnormal_melanocyte_morpholog1.86635698
22MP0000015_abnormal_ear_pigmentation1.85577170
23MP0010678_abnormal_skin_adnexa1.84957349
24MP0000613_abnormal_salivary_gland1.83234646
25MP0003941_abnormal_skin_development1.77686422
26MP0000371_diluted_coat_color1.73343359
27MP0003077_abnormal_cell_cycle1.68191666
28MP0006036_abnormal_mitochondrial_physio1.67981639
29MP0005174_abnormal_tail_pigmentation1.67551965
30MP0000462_abnormal_digestive_system1.66369297
31MP0008260_abnormal_autophagy1.63186394
32MP0005410_abnormal_fertilization1.62903294
33MP0008058_abnormal_DNA_repair1.61798869
34MP0004185_abnormal_adipocyte_glucose1.60269078
35MP0003806_abnormal_nucleotide_metabolis1.59922634
36MP0001873_stomach_inflammation1.58432730
37MP0008007_abnormal_cellular_replicative1.51224402
38MP0003111_abnormal_nucleus_morphology1.50260053
39MP0004147_increased_porphyrin_level1.49928057
40MP0002938_white_spotting1.49256596
41MP0010094_abnormal_chromosome_stability1.48750678
42MP0005171_absent_coat_pigmentation1.48057040
43MP0001929_abnormal_gametogenesis1.47401891
44MP0003136_yellow_coat_color1.45034211
45MP0002166_altered_tumor_susceptibility1.42098163
46MP0004134_abnormal_chest_morphology1.41561880
47MP0002095_abnormal_skin_pigmentation1.41555231
48MP0005220_abnormal_exocrine_pancreas1.41197040
49MP0002138_abnormal_hepatobiliary_system1.40915349
50MP0002210_abnormal_sex_determination1.37735263
51MP0002693_abnormal_pancreas_physiology1.36150774
52MP0009250_abnormal_appendicular_skeleto1.35820986
53MP0008932_abnormal_embryonic_tissue1.34732317
54MP0002277_abnormal_respiratory_mucosa1.34173665
55MP0001661_extended_life_span1.33464631
56MP0002098_abnormal_vibrissa_morphology1.32554091
57MP0006292_abnormal_olfactory_placode1.31865597
58MP0004957_abnormal_blastocyst_morpholog1.30924264
59MP0010386_abnormal_urinary_bladder1.30525401
60MP0006035_abnormal_mitochondrial_morpho1.29788701
61MP0004381_abnormal_hair_follicle1.28702831
62MP0002006_tumorigenesis1.27703183
63MP0008961_abnormal_basal_metabolism1.27648080
64MP0000647_abnormal_sebaceous_gland1.27221590
65MP0003950_abnormal_plasma_membrane1.25428932
66MP0002102_abnormal_ear_morphology1.25244956
67MP0001800_abnormal_humoral_immune1.24927154
68MP0003183_abnormal_peptide_metabolism1.24765137
69MP0004043_abnormal_pH_regulation1.24615212
70MP0003646_muscle_fatigue1.23228807
71MP0009384_cardiac_valve_regurgitation1.23118490
72MP0009333_abnormal_splenocyte_physiolog1.21532890
73MP0001835_abnormal_antigen_presentation1.20631631
74MP0000920_abnormal_myelination1.20442417
75MP0003755_abnormal_palate_morphology1.19233024
76MP0009697_abnormal_copulation1.16138013
77MP0005647_abnormal_sex_gland1.16093284
78MP0000653_abnormal_sex_gland1.15773850
79MP0002837_dystrophic_cardiac_calcinosis1.15090870
80MP0001944_abnormal_pancreas_morphology1.14696614
81MP0004215_abnormal_myocardial_fiber1.13723997
82MP0001145_abnormal_male_reproductive1.10839813
83MP0000579_abnormal_nail_morphology1.10783592
84MP0004742_abnormal_vestibular_system1.08347798
85MP0005508_abnormal_skeleton_morphology1.04395483
86MP0002177_abnormal_outer_ear1.03726259
87MP0002638_abnormal_pupillary_reflex1.03583250
88MP0001324_abnormal_eye_pigmentation1.03495549
89MP0001919_abnormal_reproductive_system1.03413500
90MP0002396_abnormal_hematopoietic_system1.03099177
91MP0008995_early_reproductive_senescence1.02797389
92MP0001790_abnormal_immune_system1.01086797
93MP0005387_immune_system_phenotype1.01086797
94MP0005253_abnormal_eye_physiology1.00226314
95MP0005395_other_phenotype1.00192645
96MP0000703_abnormal_thymus_morphology0.99859113
97MP0002398_abnormal_bone_marrow0.99421866
98MP0000432_abnormal_head_morphology0.99421414
99MP0005084_abnormal_gallbladder_morpholo0.98760501
100MP0002075_abnormal_coat/hair_pigmentati0.98244059
101MP0000627_abnormal_mammary_gland0.97921641
102MP0005551_abnormal_eye_electrophysiolog0.96870079
103MP0001119_abnormal_female_reproductive0.93972371
104MP0004264_abnormal_extraembryonic_tissu0.91511970
105MP0003656_abnormal_erythrocyte_physiolo0.91041196
106MP0001730_embryonic_growth_arrest0.90288528
107MP0010307_abnormal_tumor_latency0.89670698
108MP0003698_abnormal_male_reproductive0.89555223
109MP0003699_abnormal_female_reproductive0.89411986
110MP0003186_abnormal_redox_activity0.87157533
111MP0002019_abnormal_tumor_incidence0.86915711
112MP0005389_reproductive_system_phenotype0.85826942
113MP0001186_pigmentation_phenotype0.85752982
114MP0002060_abnormal_skin_morphology0.85215891
115MP0005266_abnormal_metabolism0.84222969
116MP0000427_abnormal_hair_cycle0.84178371
117MP0001851_eye_inflammation0.84010349
118MP0003936_abnormal_reproductive_system0.82203821
119MP0004808_abnormal_hematopoietic_stem0.82002134
120MP0002928_abnormal_bile_duct0.81776993
121MP0000689_abnormal_spleen_morphology0.80566239
122MP0005671_abnormal_response_to0.80460586
123MP0002452_abnormal_antigen_presenting0.79815821
124MP0008872_abnormal_physiological_respon0.79632540
125MP0000428_abnormal_craniofacial_morphol0.79289924
126MP0001216_abnormal_epidermal_layer0.79055197
127MP0000377_abnormal_hair_follicle0.78957469
128MP0003935_abnormal_craniofacial_develop0.78509792
129MP0000372_irregular_coat_pigmentation0.78409989
130MP0003195_calcinosis0.78020366
131MP0003868_abnormal_feces_composition0.76788847
132MP0000350_abnormal_cell_proliferation0.76767633
133MP0001485_abnormal_pinna_reflex0.75697354
134MP0002160_abnormal_reproductive_system0.74423040
135MP0003890_abnormal_embryonic-extraembry0.74370872
136MP0003786_premature_aging0.73471860
137MP0005380_embryogenesis_phenotype0.73009674
138MP0001672_abnormal_embryogenesis/_devel0.73009674
139MP0000313_abnormal_cell_death0.72846813
140MP0003943_abnormal_hepatobiliary_system0.72584048
141MP0002723_abnormal_immune_serum0.72486341
142MP0001727_abnormal_embryo_implantation0.72341455
143MP0000358_abnormal_cell_content/0.72231080
144MP0005367_renal/urinary_system_phenotyp0.71172058
145MP0000516_abnormal_urinary_system0.71172058
146MP0001697_abnormal_embryo_size0.70684909
147MP0002722_abnormal_immune_system0.69431289
148MP0006072_abnormal_retinal_apoptosis0.69402281
149MP0004142_abnormal_muscle_tone0.68889351
150MP0001529_abnormal_vocalization0.66585161
151MP0002420_abnormal_adaptive_immunity0.66459824
152MP0010352_gastrointestinal_tract_polyps0.65431723
153MP0001819_abnormal_immune_cell0.65262997
154MP0000716_abnormal_immune_system0.64074402
155MP0001764_abnormal_homeostasis0.63925499
156MP0005000_abnormal_immune_tolerance0.63617579

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)4.49646104
2Abnormality of B cell number (HP:0010975)4.20460697
3Flat capital femoral epiphysis (HP:0003370)3.88063437
4Birth length less than 3rd percentile (HP:0003561)3.74325622
5IgM deficiency (HP:0002850)3.59627794
6Dyschromatopsia (HP:0007641)3.45714056
7Small epiphyses (HP:0010585)3.43521377
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.20509974
9Increased hepatocellular lipid droplets (HP:0006565)3.19659434
10Increased CSF lactate (HP:0002490)3.14102088
11Adrenal hypoplasia (HP:0000835)3.09741261
12Papillary thyroid carcinoma (HP:0002895)3.06460576
13Mitochondrial inheritance (HP:0001427)3.05728985
14Chromsome breakage (HP:0040012)2.95350827
15IgG deficiency (HP:0004315)2.94868349
16Abnormal mitochondria in muscle tissue (HP:0008316)2.92799166
17Lipid accumulation in hepatocytes (HP:0006561)2.91455200
18Acute necrotizing encephalopathy (HP:0006965)2.89220214
19Breast hypoplasia (HP:0003187)2.87248338
20Progressive macrocephaly (HP:0004481)2.86106279
21Molar tooth sign on MRI (HP:0002419)2.80397203
22Abnormality of midbrain morphology (HP:0002418)2.80397203
23Prostate neoplasm (HP:0100787)2.79264700
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77007668
25Hepatocellular necrosis (HP:0001404)2.73866861
26Hepatic necrosis (HP:0002605)2.71663531
27Hyperglycemia (HP:0003074)2.63348354
28Submucous cleft hard palate (HP:0000176)2.61402767
29Ectopic kidney (HP:0000086)2.61066895
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59249649
31Abnormality of alanine metabolism (HP:0010916)2.59249649
32Hyperalaninemia (HP:0003348)2.59249649
33Congenital sensorineural hearing impairment (HP:0008527)2.59156689
34Irregular epiphyses (HP:0010582)2.58305301
35Increased intramyocellular lipid droplets (HP:0012240)2.53725352
36Rhabdomyosarcoma (HP:0002859)2.51181348
37Insulin-resistant diabetes mellitus (HP:0000831)2.50724575
38Parakeratosis (HP:0001036)2.46739610
39IgA deficiency (HP:0002720)2.45555728
40Abnormality of T cell physiology (HP:0011840)2.45410697
41Irregular vertebral endplates (HP:0003301)2.43497167
42Delayed epiphyseal ossification (HP:0002663)2.43200000
43Hypoplastic ischia (HP:0003175)2.42951336
44Albinism (HP:0001022)2.42699704
45Acute encephalopathy (HP:0006846)2.41287588
46Hypoplasia of the fovea (HP:0007750)2.40221598
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.40221598
48Abnormality of incisor morphology (HP:0011063)2.38835309
49Absent eyebrow (HP:0002223)2.38622560
50Facial hemangioma (HP:0000329)2.34277813
51Cupped ear (HP:0000378)2.33479287
52Biliary tract neoplasm (HP:0100574)2.32539569
53Abnormality of the femoral head (HP:0003368)2.31960289
54Fair hair (HP:0002286)2.31121207
55Abnormality of the renal cortex (HP:0011035)2.29734211
563-Methylglutaconic aciduria (HP:0003535)2.29463194
57Capillary hemangiomas (HP:0005306)2.29441606
58Abnormality of chromosome stability (HP:0003220)2.28952239
59Nephronophthisis (HP:0000090)2.28779017
60Oligodactyly (hands) (HP:0001180)2.27633240
61Neoplasm of the small intestine (HP:0100833)2.24422291
62Impulsivity (HP:0100710)2.22655843
63Thoracolumbar scoliosis (HP:0002944)2.21263297
64Renal Fanconi syndrome (HP:0001994)2.19396858
65Exertional dyspnea (HP:0002875)2.19001363
66Abnormality of the epiphysis of the femoral head (HP:0010574)2.18900132
67Ureteral duplication (HP:0000073)2.17053374
68Sparse lateral eyebrow (HP:0005338)2.16461424
69Abnormal spermatogenesis (HP:0008669)2.16427581
70Gaze-evoked nystagmus (HP:0000640)2.15330163
71Abnormality of the pons (HP:0007361)2.14736748
72Anhidrosis (HP:0000970)2.14627291
73Increased serum lactate (HP:0002151)2.13360771
74Abnormal trabecular bone morphology (HP:0100671)2.11572104
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11300917
76Clubbing of toes (HP:0100760)2.11075522
77Epiphyseal dysplasia (HP:0002656)2.10530197
78Central scotoma (HP:0000603)2.10267920
79Abnormality of the fingertips (HP:0001211)2.10203736
80Abnormality of the vertebral endplates (HP:0005106)2.09397035
81Abnormality of femoral epiphyses (HP:0006499)2.07629688
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.07629688
83Abnormality of the ischium (HP:0003174)2.05795135
84Abnormality of T cells (HP:0002843)2.05638114
85Acute myeloid leukemia (HP:0004808)2.05637676
86Colon cancer (HP:0003003)2.04318018
87Symptomatic seizures (HP:0011145)2.03675024
88Hypoplastic labia majora (HP:0000059)2.03377689
89Stillbirth (HP:0003826)2.02544733
90Myelodysplasia (HP:0002863)2.01590071
91Recurrent bronchitis (HP:0002837)2.00879472
92Cerebral edema (HP:0002181)1.99785067
93Short nail (HP:0001799)1.99565267
94Type II lissencephaly (HP:0007260)1.98563837
95Lip pit (HP:0100267)1.98274381
96Sloping forehead (HP:0000340)1.97963489
97Enlarged epiphyses (HP:0010580)1.97390466
98Increased muscle lipid content (HP:0009058)1.97365501
99Azoospermia (HP:0000027)1.97117397
100Stomatitis (HP:0010280)1.96594653
101Abnormality of the proximal phalanges of the hand (HP:0009834)1.96017940
102Conical tooth (HP:0000698)1.95979264
103Abnormality of the ileum (HP:0001549)1.95577982
104Abnormality of the renal medulla (HP:0100957)1.94559621
105Autoimmune hemolytic anemia (HP:0001890)1.94366269
106Meckel diverticulum (HP:0002245)1.94212739
107Secondary amenorrhea (HP:0000869)1.94110104
108Abnormality of the preputium (HP:0100587)1.93329530
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93314944
110Patchy hypopigmentation of hair (HP:0011365)1.92912199
111Neoplasm of the rectum (HP:0100743)1.92199004
112Pancreatic fibrosis (HP:0100732)1.91971128
113Generalized hypopigmentation of hair (HP:0011358)1.91520587
114Rough bone trabeculation (HP:0100670)1.89906187
115Abnormality of the fovea (HP:0000493)1.89747729
116Entropion (HP:0000621)1.89022437
117Hypoplasia of the uterus (HP:0000013)1.88651253
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88056227
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.88056227
120Tubulointerstitial nephritis (HP:0001970)1.85822115
121Metaphyseal irregularity (HP:0003025)1.85672162
122Barrel-shaped chest (HP:0001552)1.85662693
123Stomach cancer (HP:0012126)1.85111415
124Neoplasm of the colon (HP:0100273)1.84961252
125Male infertility (HP:0003251)1.84679057
126Posterior subcapsular cataract (HP:0007787)1.84593487
127Abnormality of the labia majora (HP:0012881)1.84551315
128Segmental peripheral demyelination/remyelination (HP:0003481)1.84351941
129Volvulus (HP:0002580)1.84235319
130White forelock (HP:0002211)1.83491922
131Abnormal pancreas size (HP:0012094)1.82945975
132Abnormal rod and cone electroretinograms (HP:0008323)1.82607575
133Abnormal biliary tract morphology (HP:0012440)1.81837098
134Respiratory difficulties (HP:0002880)1.81504116
135Abnormality of T cell number (HP:0011839)1.80054933
136Hypergonadotropic hypogonadism (HP:0000815)1.79239819
137Aplasia/hypoplasia of the uterus (HP:0008684)1.77746612
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75917946
139Congenital stationary night blindness (HP:0007642)1.75670229
140Abnormal finger flexion creases (HP:0006143)1.75439177
141Limb hypertonia (HP:0002509)1.75326165
142Gonadotropin excess (HP:0000837)1.74881825
143Short clavicles (HP:0000894)1.74377895
144Hypoplastic pelvis (HP:0008839)1.74314886
145Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74241073
146Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74241073
147Duplicated collecting system (HP:0000081)1.73424282
148Hypoglycemic seizures (HP:0002173)1.73392351
149Microglossia (HP:0000171)1.73249849
150Supernumerary spleens (HP:0009799)1.73167207
151Abnormal hair whorl (HP:0010721)1.73069537
152Severe combined immunodeficiency (HP:0004430)1.72681551
153Medulloblastoma (HP:0002885)1.72232194
154Hypoplasia of the pons (HP:0012110)1.72076748
155Lactic acidosis (HP:0003128)1.71983845
156Methylmalonic acidemia (HP:0002912)1.71931614
157Abnormality of DNA repair (HP:0003254)1.71747242
158Absent/shortened dynein arms (HP:0200106)1.71483522
159Dynein arm defect of respiratory motile cilia (HP:0012255)1.71483522
160Severe visual impairment (HP:0001141)1.70482263
161Duodenal stenosis (HP:0100867)1.69947061
162Small intestinal stenosis (HP:0012848)1.69947061
163Abnormality of the renal collecting system (HP:0004742)1.69460779
164Embryonal renal neoplasm (HP:0011794)1.68996157
165Cerebral hypomyelination (HP:0006808)1.68941317
166CNS demyelination (HP:0007305)1.68663865
167Hypoplastic iliac wings (HP:0002866)1.68425544
168Abnormality of the columella (HP:0009929)1.67870660
169Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67373818
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.67081530
171Flared iliac wings (HP:0002869)1.66156007
172Anteriorly placed anus (HP:0001545)1.63285547
173Cystic hygroma (HP:0000476)1.62715579
174Pancreatic cysts (HP:0001737)1.62474904
175Oligodactyly (HP:0012165)1.61410459
176Ectropion (HP:0000656)1.59036523
177Flattened epiphyses (HP:0003071)1.57654976
178Absent radius (HP:0003974)1.57109797
179Renal cortical cysts (HP:0000803)1.55792501
180Thyroid carcinoma (HP:0002890)1.55702985
181Premature skin wrinkling (HP:0100678)1.54357529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.21605401
2STK393.16456488
3NUAK13.14689839
4STK38L3.14305521
5AKT32.91753745
6ERBB32.44318794
7PLK42.32654818
8STK32.24139125
9SRPK12.11834117
10FRK2.11469238
11TRIM281.89279258
12MST41.88594438
13STK161.88366326
14MARK31.83992218
15INSRR1.83771601
16NEK61.80602610
17MAP3K121.77715702
18BRSK21.73235236
19TAOK31.73082694
20NLK1.68641153
21WEE11.66417593
22OXSR11.58831845
23IRAK31.58647787
24MAP3K141.58610895
25DYRK31.54542977
26BMPR1B1.54343743
27EIF2AK31.51658942
28ZAK1.48396418
29BCR1.44594598
30CDK31.44385778
31SCYL21.40685233
32CCNB11.40537377
33IRAK41.40506442
34NEK11.39317978
35WNK41.38451219
36PNCK1.32612078
37WNK31.30627058
38STK241.30292283
39MKNK21.27489940
40ERBB41.26306122
41CDK81.23527138
42DYRK21.21717855
43TXK1.19239552
44TTK1.15276306
45CDK121.14847465
46MELK1.14577213
47MAP3K31.12799832
48MAP3K41.12708841
49VRK11.11661241
50MAPK151.08664836
51PLK31.07197670
52CHEK21.07183015
53EIF2AK21.07087640
54MUSK1.03027141
55WNK11.02236029
56MAP3K131.00877765
57MKNK10.99945041
58ACVR1B0.98499043
59PIK3CA0.97212552
60CAMKK20.96696027
61MAPKAPK50.95936419
62CSNK1A1L0.95122819
63BRAF0.92639817
64CSNK1G10.90517946
65GRK10.90059982
66TNIK0.89970039
67IKBKE0.89824007
68RAF10.87320288
69PBK0.87306731
70TSSK60.85367051
71IRAK10.84256010
72HIPK20.80874446
73BRD40.80310299
74CHUK0.78073393
75PKN10.77539863
76IKBKB0.76359385
77FGFR20.74313344
78MAPK130.73889102
79PASK0.73443561
80RPS6KA50.73333372
81BUB10.72879189
82JAK30.72802931
83OBSCN0.71804246
84RPS6KA40.71397103
85TEC0.70936993
86NME10.69333722
87IRAK20.68807778
88AURKB0.68787685
89EPHA30.68142335
90SYK0.67541644
91TLK10.65528349
92LATS20.65482183
93PRKCI0.64633684
94ITK0.63766805
95PLK10.63694740
96CHEK10.63430446
97DMPK0.62909081
98ATM0.62554592
99EIF2AK10.62507089
100NEK20.62441929
101CDK70.59170001
102NME20.58134231
103PIK3CG0.56478203
104MAPK110.55122978
105PDK20.54403558
106CSNK1G30.52871510
107TAF10.52280980
108MAP3K90.52149882
109PRKCQ0.52023487
110TGFBR10.50636289
111CLK10.50371810
112CSK0.50198281
113CSNK1A10.50099879
114ATR0.49526603
115KSR10.48148143
116CSNK2A20.47168185
117DYRK1A0.46240529
118PIM10.46190996
119MAP3K20.45372688
120PDGFRB0.44985145
121CDC70.44586917
122PRKAA20.43209770
123MAP2K60.42300871
124BMPR20.41757820
125EPHA20.41025825
126ADRBK20.41003860
127PINK10.40662933
128PRKAA10.40206397
129TRPM70.39511317
130CDK90.39360613
131CSNK1E0.38826817
132PRKCE0.36713765
133LYN0.36531831
134TAOK10.36064682
135CSNK1G20.35856259
136MAP3K50.35753474
137CDK20.34849815
138* CDK10.34641599
139PLK20.34474883
140CSNK2A10.34452879

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.96442577
2Protein export_Homo sapiens_hsa030603.82013716
3RNA polymerase_Homo sapiens_hsa030203.77177599
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.20637851
5Basal transcription factors_Homo sapiens_hsa030223.17723526
6Mismatch repair_Homo sapiens_hsa034302.85834296
7Oxidative phosphorylation_Homo sapiens_hsa001902.56703784
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53848806
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.40129181
10Parkinsons disease_Homo sapiens_hsa050122.07359266
11Sphingolipid metabolism_Homo sapiens_hsa006001.97574877
12Ether lipid metabolism_Homo sapiens_hsa005651.94891173
13DNA replication_Homo sapiens_hsa030301.89794639
14Steroid biosynthesis_Homo sapiens_hsa001001.89731985
15Ribosome_Homo sapiens_hsa030101.86598782
16Selenocompound metabolism_Homo sapiens_hsa004501.82633780
17Propanoate metabolism_Homo sapiens_hsa006401.80418130
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80257605
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79384362
20Cell cycle_Homo sapiens_hsa041101.76511008
21Fanconi anemia pathway_Homo sapiens_hsa034601.69274533
22Sulfur metabolism_Homo sapiens_hsa009201.69181167
23Regulation of autophagy_Homo sapiens_hsa041401.68627214
24Linoleic acid metabolism_Homo sapiens_hsa005911.66891877
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.66849205
26RNA transport_Homo sapiens_hsa030131.65895255
27Huntingtons disease_Homo sapiens_hsa050161.61043567
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53859323
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51267282
30Homologous recombination_Homo sapiens_hsa034401.51256939
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45934436
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45466040
33One carbon pool by folate_Homo sapiens_hsa006701.44388226
34RNA degradation_Homo sapiens_hsa030181.39646983
35Alzheimers disease_Homo sapiens_hsa050101.35698416
36Vitamin digestion and absorption_Homo sapiens_hsa049771.27478765
37Pyrimidine metabolism_Homo sapiens_hsa002401.25118095
38Non-homologous end-joining_Homo sapiens_hsa034501.21811456
39Prostate cancer_Homo sapiens_hsa052151.20387286
40Circadian rhythm_Homo sapiens_hsa047101.19167206
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18873699
42Base excision repair_Homo sapiens_hsa034101.17994095
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17680637
44p53 signaling pathway_Homo sapiens_hsa041151.15790273
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.07732514
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03460063
47Proteasome_Homo sapiens_hsa030501.02773971
48Spliceosome_Homo sapiens_hsa030401.01621909
49Epstein-Barr virus infection_Homo sapiens_hsa051691.01488060
50mRNA surveillance pathway_Homo sapiens_hsa030151.01158720
51Oocyte meiosis_Homo sapiens_hsa041141.01135748
52Rheumatoid arthritis_Homo sapiens_hsa053231.00505752
53Arachidonic acid metabolism_Homo sapiens_hsa005900.99645685
54Graft-versus-host disease_Homo sapiens_hsa053320.99263542
55Autoimmune thyroid disease_Homo sapiens_hsa053200.97455367
56Purine metabolism_Homo sapiens_hsa002300.94644431
57Butanoate metabolism_Homo sapiens_hsa006500.94421545
58Herpes simplex infection_Homo sapiens_hsa051680.93992844
59TGF-beta signaling pathway_Homo sapiens_hsa043500.93663649
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.91569675
61Folate biosynthesis_Homo sapiens_hsa007900.90206937
62Caffeine metabolism_Homo sapiens_hsa002320.90056780
63Hematopoietic cell lineage_Homo sapiens_hsa046400.86338203
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85009656
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81974497
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80532748
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75813754
68Measles_Homo sapiens_hsa051620.75005555
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73909471
70MicroRNAs in cancer_Homo sapiens_hsa052060.72688322
71Fatty acid elongation_Homo sapiens_hsa000620.71426515
72FoxO signaling pathway_Homo sapiens_hsa040680.70547731
73Allograft rejection_Homo sapiens_hsa053300.69129489
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.65419776
75Malaria_Homo sapiens_hsa051440.64349484
76Olfactory transduction_Homo sapiens_hsa047400.64086518
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.60565663
78Dorso-ventral axis formation_Homo sapiens_hsa043200.59583073
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59180507
80Nucleotide excision repair_Homo sapiens_hsa034200.57765746
81Adherens junction_Homo sapiens_hsa045200.55461677
82Renal cell carcinoma_Homo sapiens_hsa052110.54910673
83Cardiac muscle contraction_Homo sapiens_hsa042600.54474028
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.54370418
85Ovarian steroidogenesis_Homo sapiens_hsa049130.53268956
86TNF signaling pathway_Homo sapiens_hsa046680.52010030
87Small cell lung cancer_Homo sapiens_hsa052220.51982129
88Phototransduction_Homo sapiens_hsa047440.51185658
89Tryptophan metabolism_Homo sapiens_hsa003800.49485986
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48850619
91Arginine and proline metabolism_Homo sapiens_hsa003300.48727657
92Lysosome_Homo sapiens_hsa041420.48107213
93T cell receptor signaling pathway_Homo sapiens_hsa046600.45606244
94Sulfur relay system_Homo sapiens_hsa041220.43181286
95Antigen processing and presentation_Homo sapiens_hsa046120.43039192
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43007859
97ECM-receptor interaction_Homo sapiens_hsa045120.42901017
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42364553
99Hepatitis C_Homo sapiens_hsa051600.41924848
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40872609
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40869683
102Influenza A_Homo sapiens_hsa051640.40842256
103Hepatitis B_Homo sapiens_hsa051610.39851068
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38181612
105Asthma_Homo sapiens_hsa053100.37533883
106Pyruvate metabolism_Homo sapiens_hsa006200.37142647
107Viral carcinogenesis_Homo sapiens_hsa052030.37074468
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36658935
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36640609
110Primary immunodeficiency_Homo sapiens_hsa053400.36388011
111Type I diabetes mellitus_Homo sapiens_hsa049400.36191684
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35856506
113Pancreatic cancer_Homo sapiens_hsa052120.35634600
114Nitrogen metabolism_Homo sapiens_hsa009100.35620569
115Choline metabolism in cancer_Homo sapiens_hsa052310.35555300
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34929870
117Other glycan degradation_Homo sapiens_hsa005110.34548931
118Apoptosis_Homo sapiens_hsa042100.33826513
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33278470
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33198600
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.31968116
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.31514613
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30929641
124Chemical carcinogenesis_Homo sapiens_hsa052040.30705677
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27679563
126Protein digestion and absorption_Homo sapiens_hsa049740.27515598
127Inositol phosphate metabolism_Homo sapiens_hsa005620.27223528
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26076774
129HTLV-I infection_Homo sapiens_hsa051660.25631837
130Prolactin signaling pathway_Homo sapiens_hsa049170.25361563
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25340128
132Peroxisome_Homo sapiens_hsa041460.25032584
133Metabolic pathways_Homo sapiens_hsa011000.24662991
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24542695
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23616539
136B cell receptor signaling pathway_Homo sapiens_hsa046620.17196657
137Retinol metabolism_Homo sapiens_hsa008300.17005254
138beta-Alanine metabolism_Homo sapiens_hsa004100.15975025
139Viral myocarditis_Homo sapiens_hsa054160.15654023
140Collecting duct acid secretion_Homo sapiens_hsa049660.14190967

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